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Aliases for URAD Gene

Aliases for URAD Gene

  • Ureidoimidazoline (2-Oxo-4-Hydroxy-4-Carboxy-5-) Decarboxylase 2 3 4
  • OHCU Decarboxylase 2 3 4
  • Parahox Cluster Neighbor 2 3
  • Parahox Neighbor 3 4
  • PRHOXNB 3 4
  • Putative 2-Oxo-4-Hydroxy-4-Carboxy-5-Ureidoimidazoline Decarboxylase 3
  • EC 4

External Ids for URAD Gene

Previous HGNC Symbols for URAD Gene


Previous GeneCards Identifiers for URAD Gene

  • GC13M028555

Summaries for URAD Gene

GeneCards Summary for URAD Gene

URAD (Ureidoimidazoline (2-Oxo-4-Hydroxy-4-Carboxy-5-) Decarboxylase) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include carboxy-lyase activity.

UniProtKB/Swiss-Prot for URAD Gene

  • Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URAD Gene

Genomics for URAD Gene

Genomic Location for URAD Gene

27,977,714 bp from pter
27,988,654 bp from pter
10,941 bases
Minus strand

Genomic View for URAD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for URAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URAD Gene

No data available for Regulatory Elements for URAD Gene

Proteins for URAD Gene

  • Protein details for URAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
    Protein Accession:
    Secondary Accessions:

    Protein attributes for URAD Gene

    173 amino acids
    Molecular mass:
    19130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for URAD Gene

Proteomics data for URAD Gene at MOPED

Post-translational modifications for URAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for URAD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for URAD Gene

Domains for URAD Gene

Protein Domains for URAD Gene

Graphical View of Domain Structure for InterPro Entry



  • A6NGE7
  • Belongs to the OHCU decarboxylase family.
genes like me logo Genes that share domains with URAD: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for URAD Gene

Function for URAD Gene

Molecular function for URAD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO(2)
UniProtKB/Swiss-Prot Function:
Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

Enzyme Numbers (IUBMB) for URAD Gene

Gene Ontology (GO) - Molecular Function for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016831 carboxy-lyase activity ISS --
genes like me logo Genes that share ontologies with URAD: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for URAD Gene

Localization for URAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for URAD Gene


Gene Ontology (GO) - Cellular Components for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IEA --
genes like me logo Genes that share ontologies with URAD: view

No data available for Subcellular locations from COMPARTMENTS for URAD Gene

Pathways for URAD Gene

SuperPathways for URAD Gene

Superpath Contained pathways
1 Metabolism
2 Purine metabolism (KEGG)
genes like me logo Genes that share pathways with URAD: view

Pathways by source for URAD Gene

2 KEGG pathways for URAD Gene

UniProtKB/Swiss-Prot A6NGE7-URAD_HUMAN

  • Pathway: Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3

Interacting Proteins for URAD Gene

Gene Ontology (GO) - Biological Process for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0008150 biological_process ND --
GO:0019428 allantoin biosynthetic process IEA --
GO:0019628 urate catabolic process IEA --
genes like me logo Genes that share ontologies with URAD: view

Transcripts for URAD Gene

mRNA/cDNA for URAD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for URAD

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for URAD Gene

No ASD Table

Relevant External Links for URAD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for URAD Gene

mRNA expression in normal human tissues for URAD Gene

mRNA differential expression in normal tissues according to GTEx for URAD Gene

This gene is overexpressed in Colon - Transverse (34.2) and Small Intestine - Terminal Ileum (13.9).

Protein differential expression in normal tissues for URAD Gene

This gene is overexpressed in Bone (62.9) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for URAD Gene

mRNA Expression by UniProt/SwissProt for URAD Gene

Tissue specificity: Apparently not expressed
genes like me logo Genes that share expressions with URAD: view

Expression partners for URAD Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for URAD Gene

Orthologs for URAD Gene

This gene was present in the common ancestor of animals.

Orthologs for URAD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia URAD 35
  • 85.69 (n)
  • 78.24 (a)
  • 79 (a)
(Canis familiaris)
Mammalia URAD 35
  • 88.44 (n)
  • 86.13 (a)
  • 85 (a)
(Mus musculus)
Mammalia Urad 35
  • 77.98 (n)
  • 80.36 (a)
Prhoxnb 16
Urad 36
  • 76 (a)
(Pan troglodytes)
Mammalia PRHOXNB 35
  • 97.44 (n)
  • 95.83 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Urad 35
  • 74.9 (n)
  • 69.28 (a)
(Monodelphis domestica)
Mammalia URAD 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia URAD 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia urad 35
  • 54.82 (n)
  • 54.82 (a)
(Danio rerio)
Actinopterygii urad 35
  • 58.19 (n)
  • 52.07 (a)
urad 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009648 35
  • 44.18 (n)
  • 33.13 (a)
Species with no ortholog for URAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URAD Gene

Gene Tree for URAD (if available)
Gene Tree for URAD (if available)

Paralogs for URAD Gene

No data available for Paralogs for URAD Gene

Variants for URAD Gene

Sequence variations from dbSNP and Humsavar for URAD Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs955224 -- 27,986,015(+) AGCTG(C/T)CGCCA intron-variant
rs955225 -- 27,986,074(+) AGCAG(A/C)CTCCA intron-variant
rs3897926 - 27,988,468(+) CTGAC(G/T)GTGCA reference, missense
rs3897927 -- 27,988,764(+) CCTTC(A/G)CGTGT upstream-variant-2KB
rs4291783 -- 27,985,750(+) acttt(C/T)tagta intron-variant

Relevant External Links for URAD Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for URAD Gene

Disorders for URAD Gene

No disorders were found for URAD Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for URAD Gene

Publications for URAD Gene

  1. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. (PMID: 16462750) Ramazzina I. … Percudani R. (Nat. Chem. Biol. 2006) 2 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4

Products for URAD Gene

Sources for URAD Gene

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