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Aliases for URAD Gene

Aliases for URAD Gene

  • Ureidoimidazoline (2-Oxo-4-Hydroxy-4-Carboxy-5-) Decarboxylase 2 3 4 5
  • OHCU Decarboxylase 2 3 4
  • Parahox Cluster Neighbor 2 3
  • PRHOXNB 3 4
  • Putative 2-Oxo-4-Hydroxy-4-Carboxy-5-Ureidoimidazoline Decarboxylase 3
  • Parahox Neighbor 4
  • EC 4.1.1.97 4

External Ids for URAD Gene

Previous HGNC Symbols for URAD Gene

  • PRHOXNB

Previous GeneCards Identifiers for URAD Gene

  • GC13M028555

Summaries for URAD Gene

GeneCards Summary for URAD Gene

URAD (Ureidoimidazoline (2-Oxo-4-Hydroxy-4-Carboxy-5-) Decarboxylase) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include carboxy-lyase activity.

UniProtKB/Swiss-Prot for URAD Gene

  • Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

Additional gene information for URAD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URAD Gene

Genomics for URAD Gene

Regulatory Elements for URAD Gene

Enhancers for URAD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H027958 1.7 FANTOM5 ENCODE dbSUPER 22.8 +18.1 18118 23 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 URAD RPL21 PLUT PDX1 GSX1 RN7SL272P CDX2 LNX2 FLT3 GC13M027960
GH13H027952 1.4 FANTOM5 ENCODE dbSUPER 8 +33.2 33186 6 FOXA2 RB1 BMI1 ZNF2 RAD21 YY1 ZNF143 ZNF207 SMARCA5 REST CDX2 PLUT PDX1 GSX1 URAD LINC00543 GC13M027960
GH13H028749 1.5 FANTOM5 Ensembl ENCODE 5.5 -764.2 -764160 6 PKNOX1 FOXA2 SIN3A YY1 ZNF766 FOS JUNB REST ZNF592 MAFF SLC46A3 CYP51A1P2 RNU6-53P URAD MTUS2 ENSG00000277227
GH13H027984 1 ENCODE dbSUPER 0.7 +4.2 4216 0 CTCF RAD21 SMC3 ZNF143 PRDM10 MIXL1 EZH2 ZNF654 TRIM22 CEBPB PDX1 PLUT GSX1 LOC105370132 URAD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around URAD on UCSC Golden Path with GeneCards custom track

Genomic Location for URAD Gene

Chromosome:
13
Start:
27,977,714 bp from pter
End:
27,988,654 bp from pter
Size:
10,941 bases
Orientation:
Minus strand

Genomic View for URAD Gene

Genes around URAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
URAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for URAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URAD Gene

Proteins for URAD Gene

  • Protein details for URAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGE7-URAD_HUMAN
    Recommended name:
    Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
    Protein Accession:
    A6NGE7

    Protein attributes for URAD Gene

    Size:
    173 amino acids
    Molecular mass:
    19130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for URAD Gene

Post-translational modifications for URAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for URAD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for URAD Gene

Domains & Families for URAD Gene

Gene Families for URAD Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for URAD Gene

Suggested Antigen Peptide Sequences for URAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGE7

UniProtKB/Swiss-Prot:

URAD_HUMAN :
  • Belongs to the OHCU decarboxylase family.
Family:
  • Belongs to the OHCU decarboxylase family.
genes like me logo Genes that share domains with URAD: view

Function for URAD Gene

Molecular function for URAD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

Enzyme Numbers (IUBMB) for URAD Gene

Phenotypes From GWAS Catalog for URAD Gene

Gene Ontology (GO) - Molecular Function for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016829 lyase activity IEA --
GO:0016831 carboxy-lyase activity ISS --
genes like me logo Genes that share ontologies with URAD: view

Phenotypes for URAD Gene

GenomeRNAi human phenotypes for URAD:
genes like me logo Genes that share phenotypes with URAD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for URAD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for URAD Gene

Localization for URAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for URAD Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for URAD gene
Compartment Confidence
peroxisome 4
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IEA --
genes like me logo Genes that share ontologies with URAD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for URAD Gene

Pathways & Interactions for URAD Gene

genes like me logo Genes that share pathways with URAD: view

Pathways by source for URAD Gene

2 KEGG pathways for URAD Gene

UniProtKB/Swiss-Prot A6NGE7-URAD_HUMAN

  • Pathway: Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.

Interacting Proteins for URAD Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000333490%0d%0a9606.ENSP00000431116%0d%0a9606.ENSP00000237014%0d%0a
Selected Interacting proteins: ENSP00000333490 for URAD Gene via STRING

Gene Ontology (GO) - Biological Process for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0008150 biological_process ND --
GO:0019428 allantoin biosynthetic process IEA --
GO:0019628 urate catabolic process IEA --
genes like me logo Genes that share ontologies with URAD: view

No data available for SIGNOR curated interactions for URAD Gene

Drugs & Compounds for URAD Gene

(1) Drugs for URAD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Allantoin Approved Nutra 10

(1) Additional Compounds for URAD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
genes like me logo Genes that share compounds with URAD: view

Transcripts for URAD Gene

mRNA/cDNA for URAD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for URAD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for URAD Gene

No ASD Table

Relevant External Links for URAD Gene

GeneLoc Exon Structure for
URAD
ECgene alternative splicing isoforms for
URAD

Expression for URAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for URAD Gene

mRNA differential expression in normal tissues according to GTEx for URAD Gene

This gene is overexpressed in Colon - Transverse (x34.2) and Small Intestine - Terminal Ileum (x13.9).

Protein differential expression in normal tissues from HIPED for URAD Gene

This gene is overexpressed in Bone (62.9) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for URAD Gene



Protein tissue co-expression partners for URAD Gene

NURSA nuclear receptor signaling pathways regulating expression of URAD Gene:

URAD

mRNA Expression by UniProt/SwissProt for URAD Gene:

A6NGE7-URAD_HUMAN
Tissue specificity: Apparently not expressed.
genes like me logo Genes that share expression patterns with URAD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for URAD Gene

Orthologs for URAD Gene

This gene was present in the common ancestor of animals.

Orthologs for URAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRHOXNB 33
  • 97.44 (n)
URAD 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia URAD 34 33
  • 88.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia URAD 33 34
  • 85.69 (n)
mouse
(Mus musculus)
Mammalia Urad 33 16 34
  • 77.98 (n)
rat
(Rattus norvegicus)
Mammalia Urad 33
  • 74.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia URAD 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia URAD 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia urad 33
  • 54.82 (n)
zebrafish
(Danio rerio)
Actinopterygii urad 33 34
  • 58.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009648 33
  • 44.18 (n)
Species where no ortholog for URAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URAD Gene

ENSEMBL:
Gene Tree for URAD (if available)
TreeFam:
Gene Tree for URAD (if available)

Paralogs for URAD Gene

No data available for Paralogs for URAD Gene

Variants for URAD Gene

Sequence variations from dbSNP and Humsavar for URAD Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000067485 -- 27,987,877(+) ATTAG(A/T)CTAAA intron-variant
rs1000349335 -- 27,982,873(+) TAAAA(A/G)AATCC intron-variant
rs1001042556 -- 27,990,411(+) TAAAC(A/C)AGTCT upstream-variant-2KB
rs1001215917 -- 27,977,810(+) GGAAT(C/T)CACAA downstream-variant-500B
rs1001391420 -- 27,981,112(+) TAGCT(C/G)GGAAG intron-variant, nc-transcript-variant

Variation tolerance for URAD Gene

Gene Damage Index Score: 12.24; 94.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for URAD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
URAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for URAD Gene

Disorders for URAD Gene

Relevant External Links for URAD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
URAD

No disorders were found for URAD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for URAD Gene

Publications for URAD Gene

  1. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. (PMID: 16462750) Ramazzina I … Percudani R (Nature chemical biology 2006) 2 3 4 60
  2. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin BM … Amundadottir LT (Nature genetics 2014) 3 60
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 4 60

Products for URAD Gene

Sources for URAD Gene

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