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Aliases for URAD Gene

Aliases for URAD Gene

  • Ureidoimidazoline (2-Oxo-4-Hydroxy-4-Carboxy-5-) Decarboxylase 2 3 4 5
  • OHCU Decarboxylase 2 3 4
  • Parahox Cluster Neighbor 2 3
  • Parahox Neighbor 3 4
  • PRHOXNB 3 4
  • Putative 2-Oxo-4-Hydroxy-4-Carboxy-5-Ureidoimidazoline Decarboxylase 3
  • EC 4

External Ids for URAD Gene

Previous HGNC Symbols for URAD Gene


Previous GeneCards Identifiers for URAD Gene

  • GC13M028555

Summaries for URAD Gene

GeneCards Summary for URAD Gene

URAD (Ureidoimidazoline (2-Oxo-4-Hydroxy-4-Carboxy-5-) Decarboxylase) is a Protein Coding gene. Among its related pathways are Purine metabolism (KEGG) and Metabolism. GO annotations related to this gene include carboxy-lyase activity.

UniProtKB/Swiss-Prot for URAD Gene

  • Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URAD Gene

Genomics for URAD Gene

Regulatory Elements for URAD Gene

Enhancers for URAD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F027958 1.7 FANTOM5 Ensembl ENCODE 22.8 +18.1 18118 23.4 PKNOX1 MLX ARID4B FEZF1 ZNF2 YY1 CBX5 ZNF143 ZNF263 SP3 URAD RPL21 PDX1-AS1 PDX1 GSX1 RN7SL272P CDX2 LNX2 FLT3 GC13M027960
GH13F028749 1.5 FANTOM5 Ensembl ENCODE 5.5 -764.2 -764160 6.3 PKNOX1 SIN3A ZBTB40 RAD21 ZNF366 ETV6 FOS CEBPB USF2 JUNB SLC46A3 CYP51A1P2 RNU6-53P URAD MTUS2 ENSG00000277227
GH13F027984 0.8 ENCODE 0.8 +4.2 4216 0.2 CTCF HINFP DDX20 ZNF175 PTRF PYGO2 CEBPG RAD21 SMC3 PRDM10 PDX1 PDX1-AS1 GSX1 PAN3-AS1 RASL11A LOC105370132 URAD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around URAD on UCSC Golden Path with GeneCards custom track

Genomic Location for URAD Gene

27,977,714 bp from pter
27,988,654 bp from pter
10,941 bases
Minus strand

Genomic View for URAD Gene

Genes around URAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
URAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for URAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URAD Gene

Proteins for URAD Gene

  • Protein details for URAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
    Protein Accession:

    Protein attributes for URAD Gene

    173 amino acids
    Molecular mass:
    19130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for URAD Gene

Post-translational modifications for URAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for URAD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for URAD Gene

Domains & Families for URAD Gene

Protein Domains for URAD Gene

Suggested Antigen Peptide Sequences for URAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OHCU decarboxylase family.
  • Belongs to the OHCU decarboxylase family.
genes like me logo Genes that share domains with URAD: view

No data available for Gene Families for URAD Gene

Function for URAD Gene

Molecular function for URAD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

Enzyme Numbers (IUBMB) for URAD Gene

Gene Ontology (GO) - Molecular Function for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016829 lyase activity IEA --
GO:0016831 carboxy-lyase activity ISS --
genes like me logo Genes that share ontologies with URAD: view

Phenotypes for URAD Gene

GenomeRNAi human phenotypes for URAD:
genes like me logo Genes that share phenotypes with URAD: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for URAD Gene

Localization for URAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for URAD Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for URAD gene
Compartment Confidence
peroxisome 4
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IEA --
genes like me logo Genes that share ontologies with URAD: view

Pathways & Interactions for URAD Gene

SuperPathway Contained pathways
1 Metabolism
2 Purine metabolism (KEGG)
genes like me logo Genes that share pathways with URAD: view

Pathways by source for URAD Gene

2 KEGG pathways for URAD Gene

UniProtKB/Swiss-Prot A6NGE7-URAD_HUMAN

  • Pathway: Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.

Interacting Proteins for URAD Gene

Gene Ontology (GO) - Biological Process for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0008150 biological_process ND --
GO:0019428 allantoin biosynthetic process IEA --
GO:0019628 urate catabolic process IEA --
genes like me logo Genes that share ontologies with URAD: view

No data available for SIGNOR curated interactions for URAD Gene

Drugs & Compounds for URAD Gene

(1) Drugs for URAD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Allantoin Nutra 8

(1) Additional Compounds for URAD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with URAD: view

Transcripts for URAD Gene

mRNA/cDNA for URAD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for URAD Gene

No ASD Table

Relevant External Links for URAD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for URAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for URAD Gene

mRNA differential expression in normal tissues according to GTEx for URAD Gene

This gene is overexpressed in Colon - Transverse (x34.2) and Small Intestine - Terminal Ileum (x13.9).

Protein differential expression in normal tissues from HIPED for URAD Gene

This gene is overexpressed in Bone (62.9) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for URAD Gene

Protein tissue co-expression partners for URAD Gene

NURSA nuclear receptor signaling pathways regulating expression of URAD Gene:


mRNA Expression by UniProt/SwissProt for URAD Gene:

Tissue specificity: Apparently not expressed.
genes like me logo Genes that share expression patterns with URAD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for URAD Gene

Orthologs for URAD Gene

This gene was present in the common ancestor of animals.

Orthologs for URAD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRHOXNB 34
  • 97.44 (n)
  • 96 (a)
(Canis familiaris)
Mammalia URAD 34 35
  • 88.44 (n)
(Bos Taurus)
Mammalia URAD 34 35
  • 85.69 (n)
(Mus musculus)
Mammalia Urad 34 16 35
  • 77.98 (n)
(Rattus norvegicus)
Mammalia Urad 34
  • 74.9 (n)
(Ornithorhynchus anatinus)
Mammalia URAD 35
  • 68 (a)
(Monodelphis domestica)
Mammalia URAD 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia urad 34
  • 54.82 (n)
(Danio rerio)
Actinopterygii urad 34 35
  • 58.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009648 34
  • 44.18 (n)
Species where no ortholog for URAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URAD Gene

Gene Tree for URAD (if available)
Gene Tree for URAD (if available)

Paralogs for URAD Gene

No data available for Paralogs for URAD Gene

Variants for URAD Gene

Sequence variations from dbSNP and Humsavar for URAD Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs111636432 -- 27,986,718(+) TTTTT(C/T)CCTGT intron-variant
rs111850310 -- 27,988,568(+) ACATC(C/T)CTCAG nc-transcript-variant, downstream-variant-500B, reference, missense
rs112196186 -- 27,983,176(+) TTGAT(C/T)TTTCT intron-variant
rs112280263 -- 27,988,121(+) GCCTG(A/G)CTAAT intron-variant
rs112351328 -- 27,981,029(+) CTCTC(-/CTCT)CTCTC intron-variant

Variation tolerance for URAD Gene

Gene Damage Index Score: 12.24; 94.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for URAD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for URAD Gene

Disorders for URAD Gene

Relevant External Links for URAD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for URAD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for URAD Gene

Publications for URAD Gene

  1. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. (PMID: 16462750) Ramazzina I. … Percudani R. (Nat. Chem. Biol. 2006) 2 3 4 64
  2. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3 64
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4 64

Products for URAD Gene

Sources for URAD Gene

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