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Aliases for URAD Gene

Aliases for URAD Gene

  • Ureidoimidazoline (2-Oxo-4-Hydroxy-4-Carboxy-5-) Decarboxylase 2 3 4
  • OHCU Decarboxylase 2 3 4
  • Parahox Cluster Neighbor 2 3
  • Parahox Neighbor 3 4
  • PRHOXNB 3 4
  • Putative 2-Oxo-4-Hydroxy-4-Carboxy-5-Ureidoimidazoline Decarboxylase 3
  • EC 4.1.1.97 4

External Ids for URAD Gene

Previous Symbols for URAD Gene

  • PRHOXNB

Summaries for URAD Gene

GeneCards Summary for URAD Gene

URAD (Ureidoimidazoline (2-Oxo-4-Hydroxy-4-Carboxy-5-) Decarboxylase) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include carboxy-lyase activity.

UniProtKB/Swiss-Prot for URAD Gene

  • Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URAD Gene

Genomics for URAD Gene

Genomic Location for URAD Gene

Start:
27,977,714 bp from pter
End:
27,988,654 bp from pter
Size:
10,941 bases
Orientation:
Minus strand

Genomic View for URAD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for URAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URAD Gene

No data available for Regulatory Elements for URAD Gene

Proteins for URAD Gene

  • Protein details for URAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGE7-URAD_HUMAN
    Recommended name:
    Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
    Protein Accession:
    A6NGE7
    Secondary Accessions:

    Protein attributes for URAD Gene

    Size:
    173 amino acids
    Molecular mass:
    19130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for URAD Gene

Proteomics data for URAD Gene at MOPED

Post-translational modifications for URAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for URAD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for URAD Gene

Domains for URAD Gene

Protein Domains for URAD Gene

UniProtKB/Swiss-Prot:

URAD_HUMAN
Family:
  • Belongs to the OHCU decarboxylase family.:
    • A6NGE7
genes like me logo Genes that share domains with URAD: view

No data available for Gene Families for URAD Gene

Function for URAD Gene

Molecular function for URAD Gene

UniProtKB/Swiss-Prot CatalyticActivity: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO(2)
UniProtKB/Swiss-Prot Function: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

Enzyme Numbers (IUBMB) for URAD Gene

Gene Ontology (GO) - Molecular Function for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016831 carboxy-lyase activity ISS --
genes like me logo Genes that share ontologies with URAD: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for URAD Gene

Localization for URAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for URAD Gene

Peroxisome.

Gene Ontology (GO) - Cellular Components for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IEA --
genes like me logo Genes that share ontologies with URAD: view

Pathways for URAD Gene

SuperPathways for URAD Gene

Superpath Contained pathways
1 Metabolism
2 Purine metabolism (KEGG)
genes like me logo Genes that share pathways with URAD: view

Pathways by source for URAD Gene

2 KEGG pathways for URAD Gene

UniProtKB/Swiss-Prot A6NGE7-URAD_HUMAN

  • Pathway: Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3

Interacting Proteins for URAD Gene

Gene Ontology (GO) - Biological Process for URAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process IEA --
GO:0008150 biological_process ND --
GO:0019428 allantoin biosynthetic process IEA --
GO:0019628 urate catabolic process IEA --
genes like me logo Genes that share ontologies with URAD: view

Transcripts for URAD Gene

mRNA/cDNA for URAD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for URAD Gene

No ASD Table

Relevant External Links for URAD Gene

GeneLoc Exon Structure for
URAD
ECgene alternative splicing isoforms for
URAD

Expression for URAD Gene

mRNA expression in normal human tissues for URAD Gene

mRNA differential expression in normal tissues according to GTEx for URAD Gene

This gene is overexpressed in Colon - Transverse (34.2) and Small Intestine - Terminal Ileum (13.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for URAD Gene

mRNA Expression by UniProt/SwissProt for URAD Gene

A6NGE7-URAD_HUMAN
Tissue specificity: Apparently not expressed
genes like me logo Genes that share expressions with URAD: view

Orthologs for URAD Gene

This gene was present in the common ancestor of animals.

Orthologs for URAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRHOXNB 36
  • 97.44 (n)
  • 95.83 (a)
URAD 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia URAD 36
  • 85.69 (n)
  • 78.24 (a)
URAD 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia URAD 36
  • 88.44 (n)
  • 86.13 (a)
URAD 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prhoxnb 16
Urad 36
  • 77.98 (n)
  • 80.36 (a)
Urad 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia URAD 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia URAD 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Urad 36
  • 74.9 (n)
  • 69.28 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia urad 36
  • 54.82 (n)
  • 54.82 (a)
zebrafish
(Danio rerio)
Actinopterygii urad 36
  • 58.19 (n)
  • 52.07 (a)
urad 37
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009648 36
  • 44.18 (n)
  • 33.13 (a)
Species with no ortholog for URAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URAD Gene

ENSEMBL:
Gene Tree for URAD (if available)
TreeFam:
Gene Tree for URAD (if available)

Paralogs for URAD Gene

No data available for Paralogs for URAD Gene

Variants for URAD Gene

Sequence variations from dbSNP and Humsavar for URAD Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs955224 -- 27,986,015(+) AGCTG(C/T)CGCCA intron-variant
rs955225 -- 27,986,074(+) AGCAG(A/C)CTCCA intron-variant
rs3897926 - 27,988,468(+) CTGAC(G/T)GTGCA reference, missense
rs3897927 -- 27,988,764(+) CCTTC(A/G)CGTGT upstream-variant-2KB
rs4291783 -- 27,985,750(+) acttt(C/T)tagta intron-variant

Relevant External Links for URAD Gene

HapMap Linkage Disequilibrium report
URAD

No data available for Structural Variations from Database of Genomic Variants (DGV) for URAD Gene

Disorders for URAD Gene

No disorders were found for URAD Gene.

No data available for UniProtKB/Swiss-Prot for URAD Gene

Publications for URAD Gene

  1. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. (PMID: 16462750) Ramazzina I. … Percudani R. (Nat. Chem. Biol. 2006) 2 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4

Products for URAD Gene

Sources for URAD Gene

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