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Aliases for UQCRH Gene

Aliases for UQCRH Gene

  • Ubiquinol-Cytochrome C Reductase Hinge Protein 2 3 5
  • Ubiquinol-Cytochrome C Reductase Complex 11 KDa Protein 3 4
  • Cytochrome C1 Non-Heme 11 KDa Protein 3 4
  • Mitochondrial Hinge Protein 3 4
  • Complex III Subunit VIII 2 4
  • Complex III Subunit 6 3 4
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit VIII 3
  • Ubiquinol-Cytochrome C Reductase 2
  • UQCR8 3
  • QCR6 3

External Ids for UQCRH Gene

Previous GeneCards Identifiers for UQCRH Gene

  • GC01P046463
  • GC01P045726
  • GC01P046155
  • GC01P046139
  • GC01P046481
  • GC01P046541
  • GC01P046769
  • GC01P044885

Summaries for UQCRH Gene

GeneCards Summary for UQCRH Gene

UQCRH (Ubiquinol-Cytochrome C Reductase Hinge Protein) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is UQCRHL.

UniProtKB/Swiss-Prot for UQCRH Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Gene Wiki entry for UQCRH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRH Gene

Genomics for UQCRH Gene

Regulatory Elements for UQCRH Gene

Promoters for UQCRH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UQCRH on UCSC Golden Path with GeneCards custom track

Genomic Location for UQCRH Gene

Chromosome:
1
Start:
46,303,613 bp from pter
End:
46,316,777 bp from pter
Size:
13,165 bases
Orientation:
Plus strand

Genomic View for UQCRH Gene

Genes around UQCRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCRH Gene

Proteins for UQCRH Gene

  • Protein details for UQCRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07919-QCR6_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 6, mitochondrial
    Protein Accession:
    P07919
    Secondary Accessions:
    • B2R4V9
    • D3DQ18
    • Q5TDF6
    • Q6LDB8
    • Q9BQ91

    Protein attributes for UQCRH Gene

    Size:
    91 amino acids
    Molecular mass:
    10739 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

neXtProt entry for UQCRH Gene

Proteomics data for UQCRH Gene at MOPED

Post-translational modifications for UQCRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UQCRH Gene

No data available for DME Specific Peptides for UQCRH Gene

Domains & Families for UQCRH Gene

Protein Domains for UQCRH Gene

Suggested Antigen Peptide Sequences for UQCRH Gene

Graphical View of Domain Structure for InterPro Entry

P07919

UniProtKB/Swiss-Prot:

QCR6_HUMAN :
  • Belongs to the UQCRH/QCR6 family.
Family:
  • Belongs to the UQCRH/QCR6 family.
genes like me logo Genes that share domains with UQCRH: view

Function for UQCRH Gene

Molecular function for UQCRH Gene

UniProtKB/Swiss-Prot Function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
genes like me logo Genes that share phenotypes with UQCRH: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCRH Gene

Localization for UQCRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRH Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCRH Gene COMPARTMENTS Subcellular localization image for UQCRH gene
Compartment Confidence
mitochondrion 5
extracellular 3
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for UQCRH Gene

Pathways & Interactions for UQCRH Gene

genes like me logo Genes that share pathways with UQCRH: view

Gene Ontology (GO) - Biological Process for UQCRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022904 respiratory electron transport chain TAS --
GO:0055114 oxidation-reduction process TAS 2826252
genes like me logo Genes that share ontologies with UQCRH: view

No data available for SIGNOR curated interactions for UQCRH Gene

Drugs & Compounds for UQCRH Gene

(10) Drugs for UQCRH Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole Experimental Pharma Target 0

(1) Additional Compounds for UQCRH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
genes like me logo Genes that share compounds with UQCRH: view

Transcripts for UQCRH Gene

Unigene Clusters for UQCRH Gene

Ubiquinol-cytochrome c reductase hinge protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRH Gene

No ASD Table

Relevant External Links for UQCRH Gene

GeneLoc Exon Structure for
UQCRH
ECgene alternative splicing isoforms for
UQCRH

Expression for UQCRH Gene

mRNA expression in normal human tissues for UQCRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCRH Gene

This gene is overexpressed in Heart - Left Ventricle (x4.3).

Protein differential expression in normal tissues from HIPED for UQCRH Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Islet of Langerhans (9.2), Brain (8.6), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRH Gene



SOURCE GeneReport for Unigene cluster for UQCRH Gene Hs.481571

genes like me logo Genes that share expression patterns with UQCRH: view

Protein tissue co-expression partners for UQCRH Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UQCRH Gene

Orthologs for UQCRH Gene

This gene was present in the common ancestor of animals.

Orthologs for UQCRH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UQCRH 35
  • 91.21 (n)
  • 93.41 (a)
UQCRH 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UQCRH 35
  • 91.94 (n)
  • 94.51 (a)
UQCRH 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9763 35
  • 81.27 (n)
  • 84.27 (a)
Gm9763 16
Uqcrh 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UQCRH 35
  • 98.9 (n)
  • 98.9 (a)
UQCRHL 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UQCRH 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves UQCRH 35
  • 76.36 (n)
  • 84.88 (a)
UQCRH 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UQCRH 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492979 35
  • 70.2 (n)
  • 75.29 (a)
Str.603 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4986 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24476 35
uqcrh 35
  • 69.8 (n)
  • 72.94 (a)
uqcrh 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30354 36
  • 40 (a)
OneToMany
Ucrh 36
  • 39 (a)
OneToMany
Species with no ortholog for UQCRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UQCRH Gene

ENSEMBL:
Gene Tree for UQCRH (if available)
TreeFam:
Gene Tree for UQCRH (if available)

Paralogs for UQCRH Gene

Paralogs for UQCRH Gene

genes like me logo Genes that share paralogs with UQCRH: view

Variants for UQCRH Gene

Sequence variations from dbSNP and Humsavar for UQCRH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34813470 - 46,310,224(-) GAGCT(C/G/T)TAGCC reference, missense
rs192972 -- 46,317,228(-) cctcc(A/C)gggtt downstream-variant-500B
rs324412 -- 46,317,275(-) cccag(C/G)ctgga downstream-variant-500B
rs438663 -- 46,311,090(+) aaaaa(A/T)aaTAA intron-variant
rs3766248 -- 46,307,816(-) TAAAA(A/T)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UQCRH Gene

Variant ID Type Subtype PubMed ID
nsv470711 CNV Gain 18288195
nsv829748 CNV Loss 17160897
esv2747907 CNV Deletion 23290073

Variation tolerance for UQCRH Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UQCRH Gene

HapMap Linkage Disequilibrium report
UQCRH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCRH Gene

Disorders for UQCRH Gene

Relevant External Links for UQCRH

Genetic Association Database (GAD)
UQCRH
Human Genome Epidemiology (HuGE) Navigator
UQCRH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UQCRH

No disorders were found for UQCRH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCRH Gene

Publications for UQCRH Gene

  1. An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein. (PMID: 2826252) Ohta S. … Kagawa Y. (FEBS Lett. 1987) 2 3 4 67
  2. UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. (PMID: 12881716) Modena P. … Sozzi G. (Oncogene 2003) 3 23
  3. Elevated expression of the human mitochondrial hinge protein gene in cancer. (PMID: 7684318) Liu A.Y. … Bradner R.C. (Cancer Res. 1993) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for UQCRH Gene

Sources for UQCRH Gene

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