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UQCRH Gene

protein-coding   GIFtS: 61
GCID: GC01P046769

Ubiquinol-Cytochrome C Reductase Hinge Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquinol-Cytochrome C Reductase Hinge Protein1 2     Ubiquinol-Cytochrome C Reductase1
Complex III Subunit VIII1 2 3     QCR62
Complex III Subunit 62 3     UQCR82
Cytochrome C1 Non-Heme 11 KDa Protein2 3     Cytochrome B-C1 Complex Subunit 6, Mitochondrial2
Mitochondrial Hinge Protein2 3     Ubiquinol-Cytochrome C Reductase, Complex III Subunit VIII2
Ubiquinol-Cytochrome C Reductase Complex 11 KDa Protein2 3     

External Ids:    HGNC: 125901   Entrez Gene: 73882   Ensembl: ENSG000001736607   OMIM: 6138445   UniProtKB: P079193   
ORGUL members:         

Export aliases for UQCRH gene to outside databases

Previous GC identifers: GC01P046463 GC01P045726 GC01P046155 GC01P046139 GC01P046481 GC01P046541 GC01P044885


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UQCRH Gene:
UQCRH (ubiquinol-cytochrome c reductase hinge protein) is a protein-coding gene. Diseases associated with UQCRH include soft tissue sarcoma, and labyrinthitis. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity and protein complex binding.

UniProtKB/Swiss-Prot: QCR6_HUMAN, P07919
Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex
between cytochromes c and c1

Gene Wiki entry for UQCRH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UQCRH gene promoter:
         ER-alpha   p53   Tal-1   Pax-6   RREB-1   E47   YY1   GATA-2   AREB6   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUQCRH promoter sequence
   Search Chromatin IP Primers for UQCRH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UQCRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

UQCRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UQCRH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046769:  view genomic region     (about GC identifiers)

Start:
46,769,303 bp from pter      End:
46,782,448 bp from pter
Size:
13,146 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: QCR6_HUMAN, P07919 (See protein sequence)
Recommended Name: Cytochrome b-c1 complex subunit 6, mitochondrial precursor  
Size: 91 amino acids; 10739 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Secondary accessions: B2R4V9 D3DQ18 Q5TDF6 Q6LDB8 Q9BQ91

Explore the universe of human proteins at neXtProt for UQCRH: NX_P07919

Explore proteomics data for UQCRH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UQCRH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005995.2  
    ENSEMBL proteins: 
     ENSP00000309565  
    Reactome Protein details: P07919

    UQCRH Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIII: Mitochondrial respiratory chain complex / Complex III

    2 InterPro protein domains:
     IPR023184 Ubol_cytC_Rdtase_hinge_dom
     IPR003422 Cyt_b-c1_6

    Graphical View of Domain Structure for InterPro Entry P07919

    ProtoNet protein and cluster: P07919

    1 Blocks protein domain: IPB003422 Ubiquinol-cytochrome C reductase hinge protein

    UniProtKB/Swiss-Prot: QCR6_HUMAN, P07919
    Similarity: Belongs to the UQCRH/QCR6 family


    UQCRH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QCR6_HUMAN, P07919
    Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
    complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex
    between cytochromes c and c1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008121ubiquinol-cytochrome-c reductase activity IEA--
    GO:0032403protein complex binding IEA--
         
    UQCRH for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UQCRH:
     Decreased G3BP1 protein expres  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UQCRH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UQCRH

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UQCRH

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    QCR6_HUMAN, P07919: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular3
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005746mitochondrial respiratory chain TAS2826252
    GO:0005750mitochondrial respiratory chain complex III IEA--

    UQCRH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UQCRH About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for UQCRH
        Electron Transport Chain


    1 Reactome Pathway for UQCRH
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for UQCRH) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    UQCRH for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UQCRH: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UQCRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UQCRH (P079193 ENSP000003095654) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYC1P085743, ENSP000003171594I2D: score=2 STRING: ENSP00000317159
    SIRT3Q9NTG73, ENSP000003721914I2D: score=2 STRING: ENSP00000372191
    COX4I1ENSP000002534524STRING: ENSP00000253452
    COX7A2LENSP000002343014STRING: ENSP00000234301
    COX8AENSP000003212604STRING: ENSP00000321260
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006119oxidative phosphorylation TAS2826252
    GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c IEA--
    GO:0009060aerobic respiration TAS2826252
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--

    UQCRH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UQCRH (QCR6)

    4 HMDB Compounds for UQCRH    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    8 DrugBank Compounds for UQCRH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    UBIQUINONE-2-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UQCRH gene: 
    NM_006004.2  

    Unigene Cluster for UQCRH:

    Ubiquinol-cytochrome c reductase hinge protein
    Hs.481571  [show with all ESTs]
    Unigene Representative Sequence: BF127835
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311672(uc001cpp.3) ENST00000489056 ENST00000486951 ENST00000496387(uc001cpq.3)
    ENST00000460947
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat UQCRH
      QuantiFast Probe-based Assays in human, mouse, rat UQCRH

    Additional mRNA sequence: 

    AK311967.1 BC001426.2 BC001934.1 BC015177.1 BC093060.1 BC107703.1 BT007070.1 M36647.1 
    Y00764.1 

    Selected DOTS entries (see all 27):

    DT.95281183  DT.95325186  DT.80100620  DT.95264706  DT.100792845  DT.121326425  DT.100685847  DT.121326476 
    DT.97760295  DT.95264675  DT.40115404  DT.95264703  DT.99949071  DT.121326544  DT.95264692  DT.121326418 
    DT.121326489  DT.121326533  DT.100685843  DT.102827459  DT.121326501  DT.91886408  DT.100685845  DT.121326342 

    Selected AceView cDNA sequences (see all 656):

    BM765268 F01061 BM991502 CR601608 BG319560 BF940090 BE910024 BQ286726 
    BG032317 AV693667 AA738347 F27786 BM682561 AA315167 BM826211 BU740911 
    H41604 N88105 CB137073 AU122825 AA788658 AA315135 BF940764 D28439 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UQCRH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTGGCTT
    UQCRH Expression
    About this image


    UQCRH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Lens
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Long Bone
    UQCRH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UQCRH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.481571
        Pathway & Disease-focused RT2 Profiler PCR Array including UQCRH: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UQCRH gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uqcrh5
    Gm97631
    ubiquinol-cytochrome c reductase hinge protein5
    predicted pseudogene 97631
    81.27(n)1
    84.27(a)1
      4 (53.10 cM)5
    1000429181  XM_006521638.11  XP_006521701.11 
     1160669655 
    chicken
    (Gallus gallus)
    Aves UQCRH1 ubiquinol-cytochrome c reductase hinge protein 76.36(n)
    84.88(a)
      771939  NM_001277673.1  NP_001264602.1 
    lizard
    (Anolis carolinensis)
    Reptilia UQCRH6
    ubiquinol-cytochrome c reductase hinge protein
    81(a)
    1 ↔ 1
    4(112161782-112167398)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.49862 Xenopus laevis transcribed sequence with moderate similarity more 78.57(n)    BG729991.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.244762 Transcribed sequence with weak similarity to protein more 75.35(n)    57083328 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG303546
    Ucrh6
    --
    Ubiquinol-cytochrome C reductase complex 11 kDa pr...
    40(a)
    39(a)
    many → 1
    many → 1
    2R(4564724-4565166)
    3LHet(606165-607415)


    ENSEMBL Gene Tree for UQCRH (if available)
    TreeFam Gene Tree for UQCRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UQCRH gene

    UQCRH for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for UQCRH (see all 9)
    PGOHUM00000238757 PGOHUM00000240602 PGOHUM00000238056 PGOHUM00000243144 PGOHUM00000235901


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UQCRH (see all 251)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115826541,2
    C,A,H--46771163(+) ggatcA/Gggagg 1 -- int10--------
    rs1456597371,2
    --46771340(+) ATGGCG/TTCAAC 1 -- int10--------
    rs588411821,2
    C--46771446(+) ATAAA-/TAAA  
            
    ATAAA
    1 -- int11Minor allele frequency- TAAA:0.00NA 2
    rs558678211,2
    --46771622(+) ACAGGC/TGCACG 1 -- int10--------
    rs1910329011,2
    --46772010(+) TAACTC/TGGGCA 1 -- int10--------
    rs797833871,2
    C--46772031(+) TTAGTT/CTTTTT 1 -- int13Minor allele frequency- C:0.22NA EA 242
    rs1833866121,2
    --46772114(+) GGCGCC/GATCTC 1 -- int10--------
    rs75482261,2
    C--46772179(+) tagctA/Gggact 1 -- int10--------
    rs1857972241,2
    --46772203(+) ATCACA/GCCCAG 1 -- int10--------
    rs606387801,2
    C--46772258(+) CCAGGG/ATGGTC 1 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for UQCRH (46769303 - 46782448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UQCRH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747907CNV Deletion23290073
    nsv829748CNV Loss17160897
    nsv470711CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613844    OMIM disorders: --

    11 diseases for UQCRH:    
    About MalaCards
    soft tissue sarcoma    labyrinthitis    huntington's disease    fatty liver disease
    parkinson's disease    sarcoma    liver disease    alzheimer's disease
    hepatocellular carcinoma    cerebritis    thyroiditis


    UQCRH for disorders           About GeneDecksing

    Genetic Association Database (GAD): UQCRH
    Human Genome Epidemiology (HuGE) Navigator: UQCRH (1 document)

    Export disorders for UQCRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UQCRH gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with UQCRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein. (PubMed id 2826252)1, 2, 3 Ohta S.... Kagawa Y. (FEBS Lett. 1987)
    2. Elevated expression of the human mitochondrial hinge protein gene in cancer. (PubMed id 7684318)1, 2, 9 Liu A.Y. and Bradner R.C. (Cancer Res. 1993)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. (PubMed id 12881716)1, 9 Modena P....Sozzi G. (Oncogene 2003)
    8. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7388 HGNC: 12590 AceView: UQCRH Ensembl:ENSG00000173660 euGenes: HUgn7388
    ECgene: UQCRH Kegg: 7388 H-InvDB: UQCRH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UQCRH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UQCRH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UQCRH gene:
    Search GeneIP for patents involving UQCRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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