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Aliases for UQCRH Gene

Aliases for UQCRH Gene

  • Ubiquinol-Cytochrome C Reductase Hinge Protein 2 3 5
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit VIII 2 3
  • Ubiquinol-Cytochrome C Reductase Complex 11 KDa Protein 3 4
  • Cytochrome C1 Non-Heme 11 KDa Protein 3 4
  • Mitochondrial Hinge Protein 3 4
  • Complex III Subunit 6 3 4
  • Cytochrome B-C1 Complex Subunit 6, Mitochondrial 3
  • Complex III Subunit VIII 4
  • UQCR8 3
  • QCR6 3

External Ids for UQCRH Gene

Previous GeneCards Identifiers for UQCRH Gene

  • GC01P046463
  • GC01P045726
  • GC01P046155
  • GC01P046139
  • GC01P046481
  • GC01P046541
  • GC01P046769
  • GC01P044885

Summaries for UQCRH Gene

GeneCards Summary for UQCRH Gene

UQCRH (Ubiquinol-Cytochrome C Reductase Hinge Protein) is a Protein Coding gene. Among its related pathways are Metabolism and Cardiac muscle contraction. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is UQCRHL.

UniProtKB/Swiss-Prot for UQCRH Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Gene Wiki entry for UQCRH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRH Gene

Genomics for UQCRH Gene

Regulatory Elements for UQCRH Gene

Enhancers for UQCRH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F046330 1.4 FANTOM5 Ensembl ENCODE 13.1 +28.9 28864 3.1 HDGF ELF3 TBP PKNOX1 TBL1XR1 WRNIP1 ARID4B BMI1 RAD21 RARA LURAP1 UQCRH LRRC41 GC01M046335 GC01P046304 GC01P046305
GH01F046338 1.2 ENCODE 12.4 +37.9 37936 5.5 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D NSUN4 EFCAB14-AS1 GPBP1L1 RPL7AP16 LURAP1 RPS15AP10 LRRC41 UQCRH CYP4B1 NENFP1
GH01F046347 1 ENCODE 11.6 +44.5 44465 0.7 HDGF ATF1 PKNOX1 ARID4B YBX1 ZNF143 REST KAT8 MEF2D MAFF NSUN4 LRRC41 UQCRH EFCAB14-AS1 CYP4B1 LURAP1 GC01M046344 ENSG00000225779
GH01F046325 0.7 ENCODE 12.8 +22.2 22196 1.1 HDGF PKNOX1 MTA2 TARDBP IKZF1 NBN MLLT1 CREM ZBTB40 EP300 LURAP1 UQCRH LRRC41 GC01M046335 GC01P046304 GC01P046305
GH01F046328 0.6 FANTOM5 12.2 +24.6 24567 0.1 HDGF ZNF146 ZNF280D POLR2A MLLT1 UQCRH LRRC41 GC01M046335 GC01P046304 GC01P046305
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UQCRH on UCSC Golden Path with GeneCards custom track

Promoters for UQCRH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000536003 -113 4601 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for UQCRH Gene

Chromosome:
1
Start:
46,303,613 bp from pter
End:
46,316,777 bp from pter
Size:
13,165 bases
Orientation:
Plus strand

Genomic View for UQCRH Gene

Genes around UQCRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCRH Gene

Proteins for UQCRH Gene

  • Protein details for UQCRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07919-QCR6_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 6, mitochondrial
    Protein Accession:
    P07919
    Secondary Accessions:
    • B2R4V9
    • D3DQ18
    • Q5TDF6
    • Q6LDB8
    • Q9BQ91

    Protein attributes for UQCRH Gene

    Size:
    91 amino acids
    Molecular mass:
    10739 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

neXtProt entry for UQCRH Gene

Post-translational modifications for UQCRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UQCRH Gene

No data available for DME Specific Peptides for UQCRH Gene

Domains & Families for UQCRH Gene

Protein Domains for UQCRH Gene

Suggested Antigen Peptide Sequences for UQCRH Gene

Graphical View of Domain Structure for InterPro Entry

P07919

UniProtKB/Swiss-Prot:

QCR6_HUMAN :
  • Belongs to the UQCRH/QCR6 family.
Family:
  • Belongs to the UQCRH/QCR6 family.
genes like me logo Genes that share domains with UQCRH: view

Function for UQCRH Gene

Molecular function for UQCRH Gene

UniProtKB/Swiss-Prot Function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Gene Ontology (GO) - Molecular Function for UQCRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008121 ubiquinol-cytochrome-c reductase activity IEA --
genes like me logo Genes that share ontologies with UQCRH: view
genes like me logo Genes that share phenotypes with UQCRH: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCRH Gene

Localization for UQCRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRH Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UQCRH gene
Compartment Confidence
mitochondrion 5
extracellular 3
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UQCRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20833797
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005746 mitochondrial respiratory chain TAS 2826252
GO:0005750 mitochondrial respiratory chain complex III IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with UQCRH: view

Pathways & Interactions for UQCRH Gene

genes like me logo Genes that share pathways with UQCRH: view

Gene Ontology (GO) - Biological Process for UQCRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006119 oxidative phosphorylation TAS 2826252
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c IEA,TAS --
GO:0009060 aerobic respiration TAS 2826252
GO:0055114 oxidation-reduction process IEA,TAS 2826252
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with UQCRH: view

No data available for SIGNOR curated interactions for UQCRH Gene

Drugs & Compounds for UQCRH Gene

(10) Drugs for UQCRH Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole Experimental Pharma Target 0

(1) Additional Compounds for UQCRH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
genes like me logo Genes that share compounds with UQCRH: view

Transcripts for UQCRH Gene

Unigene Clusters for UQCRH Gene

Ubiquinol-cytochrome c reductase hinge protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRH Gene

No ASD Table

Relevant External Links for UQCRH Gene

GeneLoc Exon Structure for
UQCRH
ECgene alternative splicing isoforms for
UQCRH

Expression for UQCRH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UQCRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCRH Gene

This gene is overexpressed in Heart - Left Ventricle (x4.3).

Protein differential expression in normal tissues from HIPED for UQCRH Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Islet of Langerhans (9.2), Brain (8.6), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UQCRH Gene



Protein tissue co-expression partners for UQCRH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UQCRH Gene:

UQCRH

SOURCE GeneReport for Unigene cluster for UQCRH Gene:

Hs.481571
genes like me logo Genes that share expression patterns with UQCRH: view

No data available for mRNA Expression by UniProt/SwissProt for UQCRH Gene

Orthologs for UQCRH Gene

This gene was present in the common ancestor of animals.

Orthologs for UQCRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UQCRHL 35
  • 99 (a)
OneToOne
UQCRH 34
  • 98.9 (n)
mouse
(Mus musculus)
Mammalia Uqcrh 35
  • 92 (a)
OneToOne
Gm9763 34
  • 81.27 (n)
Uqcrh-ps1 16
dog
(Canis familiaris)
Mammalia UQCRH 34 35
  • 91.94 (n)
cow
(Bos Taurus)
Mammalia UQCRH 34 35
  • 91.21 (n)
oppossum
(Monodelphis domestica)
Mammalia UQCRH 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves UQCRH 34 35
  • 76.36 (n)
lizard
(Anolis carolinensis)
Reptilia UQCRH 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492979 34
  • 70.2 (n)
Str.603 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4986 34
zebrafish
(Danio rerio)
Actinopterygii uqcrh 34 35
  • 69.8 (n)
Dr.24476 34
fruit fly
(Drosophila melanogaster)
Insecta CG30354 35
  • 40 (a)
OneToMany
Ucrh 35
  • 39 (a)
OneToMany
Species where no ortholog for UQCRH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UQCRH Gene

ENSEMBL:
Gene Tree for UQCRH (if available)
TreeFam:
Gene Tree for UQCRH (if available)

Paralogs for UQCRH Gene

Paralogs for UQCRH Gene

genes like me logo Genes that share paralogs with UQCRH: view

Variants for UQCRH Gene

Sequence variations from dbSNP and Humsavar for UQCRH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10581963 -- 46,304,388(+) ATTAA(-/T)TTTTT intron-variant, upstream-variant-2KB
rs111646431 -- 46,316,464(+) AGAGG(G/T)GCAGT intron-variant
rs111697097 -- 46,309,058(+) ATATG(C/T)CATAA intron-variant
rs111733251 -- 46,316,606(+) CACCC(-/CA)GTCTT utr-variant-3-prime
rs111845603 -- 46,313,234(+) TGCTT(A/G)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UQCRH Gene

Variant ID Type Subtype PubMed ID
nsv829748 CNV loss 17160897
nsv470711 CNV gain 18288195
esv2761743 CNV gain 21179565

Variation tolerance for UQCRH Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UQCRH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UQCRH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCRH Gene

Disorders for UQCRH Gene

Relevant External Links for UQCRH

Genetic Association Database (GAD)
UQCRH
Human Genome Epidemiology (HuGE) Navigator
UQCRH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UQCRH

No disorders were found for UQCRH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCRH Gene

Publications for UQCRH Gene

  1. Elevated expression of the human mitochondrial hinge protein gene in cancer. (PMID: 7684318) Liu A.Y. … Bradner R.C. (Cancer Res. 1993) 3 4 22 64
  2. An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein. (PMID: 2826252) Ohta S. … Kagawa Y. (FEBS Lett. 1987) 2 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for UQCRH Gene

Sources for UQCRH Gene

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