Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UQCRH Gene

protein-coding   GIFtS: 61
GCID: GC01P046769

Ubiquinol-Cytochrome C Reductase Hinge Protein

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquinol-Cytochrome C Reductase Hinge Protein1 2     Ubiquinol-Cytochrome C Reductase1
Complex III Subunit VIII1 2 3     QCR62
Complex III Subunit 62 3     UQCR82
Cytochrome C1 Non-Heme 11 KDa Protein2 3     Cytochrome B-C1 Complex Subunit 6, Mitochondrial2
Mitochondrial Hinge Protein2 3     Ubiquinol-Cytochrome C Reductase, Complex III Subunit VIII2
Ubiquinol-Cytochrome C Reductase Complex 11 KDa Protein2 3     

External Ids:    HGNC: 125901   Entrez Gene: 73882   Ensembl: ENSG000001736607   OMIM: 6138445   UniProtKB: P079193   

Export aliases for UQCRH gene to outside databases

Previous GC identifers: GC01P046463 GC01P045726 GC01P046155 GC01P046139 GC01P046481 GC01P046541 GC01P044885


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UQCRH Gene: 
UQCRH (ubiquinol-cytochrome c reductase hinge protein) is a protein-coding gene. Diseases associated with UQCRH include soft tissue sarcoma, and huntington's disease, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity and protein complex binding.

UniProtKB/Swiss-Prot: QCR6_HUMAN, P07919
Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex
between cytochromes c and c1

Gene Wiki entry for UQCRH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UQCRH gene promoter:
         ER-alpha   p53   Tal-1   Pax-6   RREB-1   E47   YY1   GATA-2   AREB6   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUQCRH promoter sequence
   Search SABiosciences Chromatin IP Primers for UQCRH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UQCRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

UQCRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UQCRH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046769:  view genomic region     (about GC identifiers)

Start:
46,769,303 bp from pter      End:
46,782,448 bp from pter
Size:
13,146 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: QCR6_HUMAN, P07919 (See protein sequence)
Recommended Name: Cytochrome b-c1 complex subunit 6, mitochondrial precursor  
Size: 91 amino acids; 10739 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Subcellular location: Mitochondrion inner membrane
Secondary accessions: B2R4V9 D3DQ18 Q5TDF6 Q6LDB8 Q9BQ91

Explore the universe of human proteins at neXtProt for UQCRH: NX_P07919

Explore proteomics data for UQCRH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07919

  • UQCRH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UQCRH Protein Expression
    REFSEQ proteins: NP_005995.2  
    ENSEMBL proteins: 
     ENSP00000309565  
    Reactome Protein details: P07919
    Human Recombinant Protein Products for UQCRH: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UQCRH
    OriGene Protein Over-expression Lysate for UQCRH
    OriGene MassSpec for UQCRH 
    OriGene Custom Protein Services for UQCRH
    GenScript Custom Purified and Recombinant Proteins Services for UQCRH
    Novus Biologicals UQCRH Proteins
    Novus Biologicals UQCRH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UQCRH 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005746mitochondrial respiratory chain TAS2826252
    GO:0005750mitochondrial respiratory chain complex III IEA--

    UQCRH for ontologies           About GeneDecksing



    UQCRH Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UQCRH
    OriGene Custom Antibody Services for UQCRH
    GenScript Custom Superior Antibodies Services for UQCRH
    Novus Biologicals UQCRH Antibodies
    Abcam antibodies for UQCRH
    Cloud-Clone Corp. Antibodies for UQCRH 
    Search ThermoFisher Antibodies for UQCRH
    LSBio Antibodies in human, mouse, rat for UQCRH 

    Assay Products for UQCRH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UQCRH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UQCRH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UQCRH 
    Cloud-Clone Corp. CLIAs for UQCRH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comIII: Mitochondrial respiratory chain complex / Complex III

    2 InterPro protein domains:
     IPR023184 Ubol_cytC_Rdtase_hinge_dom
     IPR003422 Cyt_b-c1_6

    Graphical View of Domain Structure for InterPro Entry P07919

    ProtoNet protein and cluster: P07919

    1 Blocks protein domain: IPB003422 Ubiquinol-cytochrome C reductase hinge protein

    UniProtKB/Swiss-Prot: QCR6_HUMAN, P07919
    Similarity: Belongs to the UQCRH/QCR6 family


    UQCRH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QCR6_HUMAN, P07919
    Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
    complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex
    between cytochromes c and c1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008121ubiquinol-cytochrome-c reductase activity IEA--
    GO:0032403protein complex binding IEA--
         
    UQCRH for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UQCRH:
     Decreased G3BP1 protein expres  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UQCRH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UQCRH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UQCRH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UQCRH 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UQCRH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UQCRH
    SwitchGear 3'UTR luciferase reporter plasmidUQCRH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UQCRH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UQCRH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UQCRH
    Sirion Biotech Customized adenovirus for overexpression of UQCRH

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UQCRH (see all 9)
    OriGene ORF clones in mouse, rat for UQCRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UQCRH (NM_006004)
    Sino Biological Human cDNA Clone for UQCRH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UQCRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRH
    Sirion Biotech Customized lentivirus for stable overexpression of UQCRH 
                         Customized lentivirus expression plasmids for stable overexpression of UQCRH 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UQCRH
    Search LifeMap BioReagents cell lines for UQCRH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UQCRH About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Huntington's disease0.47
    Electron Transport Chain0.75
    Alzheimer's disease0.46
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Cardiac muscle contraction
    Cardiac muscle contraction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for UQCRH
        Electron Transport Chain


    4        Reactome Pathways for UQCRH
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/7         Kegg Pathways  (Kegg details for UQCRH) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    UQCRH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UQCRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/88 Interacting proteins for UQCRH (P079193 ENSP000003095654) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYC1P085743, ENSP000003171594I2D: score=2 STRING: ENSP00000317159
    SIRT3Q9NTG73, ENSP000003721914I2D: score=2 STRING: ENSP00000372191
    COX4I1ENSP000002534524STRING: ENSP00000253452
    COX7A2LENSP000002343014STRING: ENSP00000234301
    COX8AENSP000003212604STRING: ENSP00000321260
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006119oxidative phosphorylation TAS2826252
    GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c IEA--
    GO:0009060aerobic respiration TAS2826252
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--

    UQCRH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UQCRH (QCR6)

    4 HMDB Compounds for UQCRH    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    8 DrugBank Compounds for UQCRH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    UBIQUINONE-2-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about UQCRH / QCR6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UQCRH gene: 
    NM_006004.2  

    Unigene Cluster for UQCRH:

    Ubiquinol-cytochrome c reductase hinge protein
    Hs.481571  [show with all ESTs]
    Unigene Representative Sequence: BF127835
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311672(uc001cpp.3) ENST00000489056 ENST00000486951 ENST00000496387(uc001cpq.3)
    ENST00000460947

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UQCRH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UQCRH
    SwitchGear 3'UTR luciferase reporter plasmidUQCRH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UQCRH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UQCRH
    Clone
    Products:
         
    OriGene clones in human, mouse for UQCRH (see all 9)
    OriGene ORF clones in mouse, rat for UQCRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UQCRH (NM_006004)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UQCRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRH
    Sirion Biotech Customized lentivirus for stable overexpression of UQCRH 
                         Customized lentivirus expression plasmids for stable overexpression of UQCRH 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UQCRH
    OriGene qSTAR qPCR primer pairs in human, mouse for UQCRH
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UQCRH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UQCRH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UQCRH

    Additional mRNA sequence: 

    AK311967.1 BC001426.2 BC001934.1 BC015177.1 BC093060.1 BC107703.1 BT007070.1 M36647.1 
    Y00764.1 

    24/27 DOTS entries (see all 27):

    DT.95281183  DT.95325186  DT.80100620  DT.95264706  DT.100792845  DT.121326425  DT.100685847  DT.121326476 
    DT.97760295  DT.95264675  DT.40115404  DT.95264703  DT.99949071  DT.121326544  DT.95264692  DT.121326418 
    DT.121326489  DT.121326533  DT.100685843  DT.102827459  DT.121326501  DT.91886408  DT.100685845  DT.121326342 

    24/656 AceView cDNA sequences (see all 656):

    BM052859 BG286607 BM716744 BE122675 AW514216 BX357997 AA132228 BQ680774 
    CD172109 BM784773 AI720008 CB109172 N68339 CA843067 BM701256 AA844201 
    BM787256 BF726456 BU731467 AI081287 CB117881 AA709375 BQ065841 BM757760 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UQCRH expression in normal human tissues (normalized intensities)      UQCRH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTGGCTT
    UQCRH Expression
    About this image


    UQCRH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 7 entries
             Ureter
             visceral organ   
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             brain/midbrain   
     
     Nose (Sensory Organs)    fully expand to see all 7 entries
             sensory organ/nose/naso-lacrimal duct   
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Autopod
             limb/hindlimb   
     
     Tooth
             visceral organ/oral region/upper jaw   

    See UQCRH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UQCRH

    SOURCE GeneReport for Unigene cluster: Hs.481571
        SABiosciences Expression via Pathway-Focused PCR Array including UQCRH: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UQCRH
    OriGene qSTAR qPCR primer pairs in human, mouse for UQCRH
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UQCRH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UQCRH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UQCRH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UQCRH gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uqcrh1 , 5 ubiquinol-cytochrome c reductase hinge protein1, 5 84.64(n)1
    92.13(a)1
      4 (53.10 cM)5
    665761  NM_025641.31  NP_079917.11 
     1160669655 
    chicken
    (Gallus gallus)
    Aves UQCRH1 ubiquinol-cytochrome c reductase hinge protein 75.58(n)
    84.88(a)
      771939  XM_001235147.2  XP_001235148.2 
    lizard
    (Anolis carolinensis)
    Reptilia UQCRH6
    Cytochrome b-c1 complex subunit 6
    80(a)
    1 ↔ 1
    4(112161782-112167398)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.49862 Xenopus laevis transcribed sequence with moderate similarity more 78.57(n)    BG729991.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.244762 Transcribed sequence with weak similarity to protein more 75.35(n)    57083328 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG303546
    Ucrh6
    --
    Ubiquinol-cytochrome C reductase complex 11 kDa pr...
    38(a)
    38(a)
    many → 1
    many → 1
    2R(4564724-4565166)
    3LHet(606165-607415)
    worm
    (Caenorhabditis elegans)
    Secernentea T27E9.26
    Protein T27E9.2
    40(a)
    1 ↔ 1
    III(13462239-13462755)


    ENSEMBL Gene Tree for UQCRH (if available)
    TreeFam Gene Tree for UQCRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UQCRH gene

    UQCRH for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for UQCRH (see all 9)
    PGOHUM00000238757 PGOHUM00000240602 PGOHUM00000238056 PGOHUM00000243144 PGOHUM00000235901


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/251 SNPs in UQCRH are shown (see all 251)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115826541,2
    C,A,H--46771163(+) ggatcA/Gggagg 1 -- int10--------
    rs1456597371,2
    --46771340(+) ATGGCG/TTCAAC 1 -- int10--------
    rs588411821,2
    C--46771446(+) ATAAA-/TAAA  
            
    ATAAA
    1 -- int11Minor allele frequency- TAAA:0.00NA 2
    rs558678211,2
    --46771622(+) ACAGGC/TGCACG 1 -- int10--------
    rs1910329011,2
    --46772010(+) TAACTC/TGGGCA 1 -- int10--------
    rs797833871,2
    C--46772031(+) TTAGTT/CTTTTT 1 -- int13Minor allele frequency- C:0.22NA EA 242
    rs1833866121,2
    --46772114(+) GGCGCC/GATCTC 1 -- int10--------
    rs75482261,2
    C--46772179(+) tagctA/Gggact 1 -- int10--------
    rs1857972241,2
    --46772203(+) ATCACA/GCCCAG 1 -- int10--------
    rs606387801,2
    C--46772258(+) CCAGGG/ATGGTC 1 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for UQCRH (46769303 - 46782448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UQCRH:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747907CNV Deletion23290073
    nsv829748CNV Loss17160897
    nsv470711CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UQCRH
    DNA2.0 Custom Variant and Variant Library Synthesis for UQCRH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613844    OMIM disorders: --

    6 diseases for UQCRH:    About MalaCards
    soft tissue sarcoma    huntington's disease    parkinson's disease    sarcoma
    hepatocellular carcinoma    alzheimer's disease


    UQCRH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): UQCRH
    Human Genome Epidemiology (HuGE) Navigator: UQCRH (1 document)

    Export disorders for UQCRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UQCRH gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with UQCRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein. (PubMed id 2826252)1, 2, 3 Ohta S.... Kagawa Y. (1987)
    2. Elevated expression of the human mitochondrial hinge protein gene in cancer. (PubMed id 7684318)1, 2, 9 Liu A.Y. and Bradner R.C. (1993)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. (PubMed id 12881716)1, 9 Modena P....Sozzi G. (2003)
    8. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7388 HGNC: 12590 AceView: UQCRH Ensembl:ENSG00000173660 euGenes: HUgn7388
    ECgene: UQCRH Kegg: 7388 H-InvDB: UQCRH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UQCRH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UQCRH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UQCRH gene:
    Search GeneIP for patents involving UQCRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UQCRH   OriGene RNAi products in human, mouse, rat for UQCRH  
     OriGene qPCR primer pairs and template standards for UQCRH   OriGene Protein Over-expression Lysate for UQCRH  
     OriGene MassSpec something-or-other for UQCRH   OriGene clones in human, mouse for UQCRH  
     OriGene qSTAR qPCR primer pairs in human, mouse for UQCRH   OriGene Purified Protein for UQCRH  
     OriGene ORF clones in mouse, rat for UQCRH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UQCRH   OriGene Custom Protein Services for UQCRH  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UQCRH
     QIAGEN SeqTarget long-range PCR primers for resequencing UQCRH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UQCRH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UQCRH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UQCRH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UQCRH
     GenScript Custom Purified and Recombinant Proteins Services for UQCRH GenScript cDNA clones with any tag delivered in your preferred vector for UQCRH
     GenScript Custom Assay Services for UQCRH GenScript Custom Superior Antibodies Services for UQCRH
     GenScript Custom overexpressing Cell Line Services for UQCRH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UQCRH promoter
     Search Chromatin IP Primers for UQCRH
     RT2 qPCR Primer Assay in human, mouse / rat UQCRH
     Search GNC Networks for UQCRH
     SABiosciences PCR Arrays including human, mouse, rat UQCRH
     Search Tocris compounds for UQCRH (QCR6)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for UQCRH
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UQCRH antibodies
     UQCRH proteins
     UQCRH lysates
     Antibodies for UQCRH
     See all of Abcam's Antibodies, Kits and Proteins for UQCRH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UQCRH
     Antibodies for UQCRH
     ELISAs for UQCRH
     CLIAs for UQCRH
     Search LifeMap BioReagents cell lines for UQCRH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRH
     SwitchGear 3'UTR luciferase reporter plasmids for UQCRH
     SwitchGear Promoter luciferase reporter plasmids for UQCRH
     Search ThermoFisher Antibodies for UQCRH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRH
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UQCRH
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UQCRH
    Customized:
     lentivirus for stable overexpression of UQCRH
     lentivirus expression plasmids for stable overexpression of UQCRH
     adenovirus for overexpression of UQCRH
     LSBio Antibodies in human, mouse, rat for UQCRH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UQCRH gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4