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Aliases for UQCRH Gene

Aliases for UQCRH Gene

  • Ubiquinol-Cytochrome C Reductase Hinge Protein 2 3
  • Ubiquinol-Cytochrome C Reductase Complex 11 KDa Protein 3 4
  • Cytochrome C1 Non-Heme 11 KDa Protein 3 4
  • Mitochondrial Hinge Protein 3 4
  • Complex III Subunit VIII 2 4
  • Complex III Subunit 6 3 4
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit VIII 3
  • Cytochrome B-C1 Complex Subunit 6, Mitochondrial 3
  • Ubiquinol-Cytochrome C Reductase 2
  • UQCR8 3
  • QCR6 3

External Ids for UQCRH Gene

Summaries for UQCRH Gene

GeneCards Summary for UQCRH Gene

UQCRH (Ubiquinol-Cytochrome C Reductase Hinge Protein) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein complex binding and ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot for UQCRH Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1

Gene Wiki entry for UQCRH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRH Gene

Genomics for UQCRH Gene

Genomic Location for UQCRH Gene

Start:
46,303,631 bp from pter
End:
46,316,776 bp from pter
Size:
13,146 bases
Orientation:
Plus strand

Genomic View for UQCRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UQCRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCRH Gene

Regulatory Elements for UQCRH Gene

Proteins for UQCRH Gene

  • Protein details for UQCRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07919-QCR6_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 6, mitochondrial
    Protein Accession:
    P07919
    Secondary Accessions:
    • B2R4V9
    • D3DQ18
    • Q5TDF6
    • Q6LDB8
    • Q9BQ91

    Protein attributes for UQCRH Gene

    Size:
    91 amino acids
    Molecular mass:
    10739 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)

neXtProt entry for UQCRH Gene

Proteomics data for UQCRH Gene at MOPED

Post-translational modifications for UQCRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UQCRH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UQCRH Gene

Domains for UQCRH Gene

Gene Families for UQCRH Gene

HGNC:
  • comIII :Mitochondrial respiratory chain complex / Complex III

Protein Domains for UQCRH Gene

UniProtKB/Swiss-Prot:

QCR6_HUMAN
Family:
  • Belongs to the UQCRH/QCR6 family.:
    • P07919
genes like me logo Genes that share domains with UQCRH: view

Function for UQCRH Gene

Molecular function for UQCRH Gene

UniProtKB/Swiss-Prot Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1

Gene Ontology (GO) - Molecular Function for UQCRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008121 ubiquinol-cytochrome-c reductase activity IEA --
genes like me logo Genes that share ontologies with UQCRH: view
genes like me logo Genes that share phenotypes with UQCRH: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UQCRH Gene

Localization for UQCRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRH Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCRH Gene COMPARTMENTS Subcellular localization image for UQCRH gene
Compartment Confidence
mitochondrion 5
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UQCRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005746 mitochondrial respiratory chain TAS 2826252
genes like me logo Genes that share ontologies with UQCRH: view

Pathways for UQCRH Gene

genes like me logo Genes that share pathways with UQCRH: view

Gene Ontology (GO) - Biological Process for UQCRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006119 oxidative phosphorylation TAS 2826252
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c IEA --
GO:0009060 aerobic respiration TAS 2826252
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with UQCRH: view

Compounds for UQCRH Gene

(4) HMDB Compounds for UQCRH Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
QH2
  • CoQH2
56275-39-9
Ubiquinone Q1
  • Coenzyme Q
727-81-1
Ubiquinone Q2
  • 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
606-06-4

(8) Drugbank Compounds for UQCRH Gene

genes like me logo Genes that share compounds with UQCRH: view

Transcripts for UQCRH Gene

Unigene Clusters for UQCRH Gene

Ubiquinol-cytochrome c reductase hinge protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRH Gene

No ASD Table

Relevant External Links for UQCRH Gene

GeneLoc Exon Structure for
UQCRH
ECgene alternative splicing isoforms for
UQCRH

Expression for UQCRH Gene

mRNA expression in normal human tissues for UQCRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCRH Gene

This gene is overexpressed in Heart - Left Ventricle (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRH Gene

SOURCE GeneReport for Unigene cluster for UQCRH Gene Hs.481571

genes like me logo Genes that share expressions with UQCRH: view

Orthologs for UQCRH Gene

This gene was present in the common ancestor of animals.

Orthologs for UQCRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UQCRH 36
  • 98.9 (n)
  • 98.9 (a)
UQCRHL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UQCRH 36
  • 91.21 (n)
  • 93.41 (a)
UQCRH 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UQCRH 36
  • 91.94 (n)
  • 94.51 (a)
UQCRH 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9763 36
  • 81.27 (n)
  • 84.27 (a)
Uqcrh 16
Uqcrh 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UQCRH 37
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves UQCRH 36
  • 76.36 (n)
  • 84.88 (a)
UQCRH 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UQCRH 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4986 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492979 36
  • 70.2 (n)
  • 75.29 (a)
Str.603 36
zebrafish
(Danio rerio)
Actinopterygii Dr.24476 36
uqcrh 36
  • 69.8 (n)
  • 72.94 (a)
uqcrh 37
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30354 37
  • 40 (a)
OneToMany
Ucrh 37
  • 39 (a)
OneToMany
Species with no ortholog for UQCRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UQCRH Gene

ENSEMBL:
Gene Tree for UQCRH (if available)
TreeFam:
Gene Tree for UQCRH (if available)

Paralogs for UQCRH Gene

genes like me logo Genes that share paralogs with UQCRH: view

No data available for Paralogs for UQCRH Gene

Variants for UQCRH Gene

Sequence variations from dbSNP and Humsavar for UQCRH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs192972 -- 46,317,228(-) cctcc(A/C)gggtt downstream-variant-500B
rs324412 -- 46,317,275(-) cccag(C/G)ctgga downstream-variant-500B
rs438663 -- 46,311,090(+) aaaaa(A/T)aaTAA intron-variant
rs3766248 -- 46,307,816(-) TAAAA(A/T)CCCTT intron-variant
rs4660920 -- 46,315,790(+) GATTT(C/G)TATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UQCRH Gene

Variant ID Type Subtype PubMed ID
nsv470711 CNV Gain 18288195
nsv829748 CNV Loss 17160897
esv2747907 CNV Deletion 23290073

Relevant External Links for UQCRH Gene

HapMap Linkage Disequilibrium report
UQCRH

Disorders for UQCRH Gene

Relevant External Links for UQCRH

Genetic Association Database (GAD)
UQCRH
Human Genome Epidemiology (HuGE) Navigator
UQCRH
genes like me logo Genes that share disorders with UQCRH: view

No data available for UniProtKB/Swiss-Prot for UQCRH Gene

Publications for UQCRH Gene

  1. Elevated expression of the human mitochondrial hinge protein gene in cancer. (PMID: 7684318) Liu A.Y. … Bradner R.C. (Cancer Res. 1993) 3 4 23
  2. An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein. (PMID: 2826252) Ohta S. … Kagawa Y. (FEBS Lett. 1987) 2 3 4
  3. UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. (PMID: 12881716) Modena P. … Sozzi G. (Oncogene 2003) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for UQCRH Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate UQCRH
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for UQCRH
    • Block miRNA regulation of UQCRH using miScript Target Protectors

    Sources for UQCRH Gene

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