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Aliases for UQCRFS1 Gene

Aliases for UQCRFS1 Gene

  • Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 2 3 5
  • Cytochrome B-C1 Complex Subunit 5 2 3 4
  • Ubiquinol-Cytochrome C Reductase Iron-Sulfur Subunit 3 4
  • Rieske Iron-Sulfur Protein 3 4
  • Complex III Subunit 5 3 4
  • EC 1.10.2.2 4 63
  • RISP 3 4
  • UQCR5 3
  • RIP1 3
  • RIS1 3

External Ids for UQCRFS1 Gene

Previous GeneCards Identifiers for UQCRFS1 Gene

  • GC19M030318
  • GC19M030147
  • GC19M034374
  • GC19M034390
  • GC19M029698

Summaries for UQCRFS1 Gene

GeneCards Summary for UQCRFS1 Gene

UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include oxidoreductase activity and 2 iron, 2 sulfur cluster binding.

UniProtKB/Swiss-Prot for UQCRFS1 Gene

  • Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

  • The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex.

Gene Wiki entry for UQCRFS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRFS1 Gene

Genomics for UQCRFS1 Gene

Regulatory Elements for UQCRFS1 Gene

Promoters for UQCRFS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UQCRFS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UQCRFS1 Gene

Chromosome:
19
Start:
29,205,321 bp from pter
End:
29,213,541 bp from pter
Size:
8,221 bases
Orientation:
Minus strand

Genomic View for UQCRFS1 Gene

Genes around UQCRFS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCRFS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCRFS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCRFS1 Gene

Proteins for UQCRFS1 Gene

  • Protein details for UQCRFS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47985-UCRI_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit Rieske, mitochondrial
    Protein Accession:
    P47985
    Secondary Accessions:
    • A8K519
    • Q6NVX5
    • Q9UPH2

    Protein attributes for UQCRFS1 Gene

    Size:
    274 amino acids
    Molecular mass:
    29668 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
    Miscellaneous:
    • The Rieske protein is a high potential 2Fe-2S protein.

neXtProt entry for UQCRFS1 Gene

Proteomics data for UQCRFS1 Gene at MOPED

Post-translational modifications for UQCRFS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UQCRFS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for UQCRFS1 Gene

Suggested Antigen Peptide Sequences for UQCRFS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47985

UniProtKB/Swiss-Prot:

UCRI_HUMAN :
  • Contains 1 Rieske domain.
Domain:
  • Contains 1 Rieske domain.
genes like me logo Genes that share domains with UQCRFS1: view

Function for UQCRFS1 Gene

Molecular function for UQCRFS1 Gene

GENATLAS Biochemistry:
Rieske iron sulfur protein 1,subunit of cytochrome bc1 complex III,mitochondrial respiratory chain,oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot CatalyticActivity:
Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+).
UniProtKB/Swiss-Prot Function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
UniProtKB/Swiss-Prot Function:
The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex.

Enzyme Numbers (IUBMB) for UQCRFS1 Gene

genes like me logo Genes that share phenotypes with UQCRFS1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UQCRFS1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCRFS1 Gene

Localization for UQCRFS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRFS1 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCRFS1 Gene COMPARTMENTS Subcellular localization image for UQCRFS1 gene
Compartment Confidence
mitochondrion 5
chloroplast 2

No data available for Gene Ontology (GO) - Cellular Components for UQCRFS1 Gene

Pathways & Interactions for UQCRFS1 Gene

genes like me logo Genes that share pathways with UQCRFS1: view

Gene Ontology (GO) - Biological Process for UQCRFS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046677 response to antibiotic IEA --
genes like me logo Genes that share ontologies with UQCRFS1: view

No data available for SIGNOR curated interactions for UQCRFS1 Gene

Drugs & Compounds for UQCRFS1 Gene

(13) Drugs for UQCRFS1 Gene - From: HMDB, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE Experimental Pharma Target 0

(7) Additional Compounds for UQCRFS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
genes like me logo Genes that share compounds with UQCRFS1: view

Transcripts for UQCRFS1 Gene

mRNA/cDNA for UQCRFS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(427) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UQCRFS1 Gene

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRFS1 Gene

No ASD Table

Relevant External Links for UQCRFS1 Gene

GeneLoc Exon Structure for
UQCRFS1
ECgene alternative splicing isoforms for
UQCRFS1

Expression for UQCRFS1 Gene

mRNA expression in normal human tissues for UQCRFS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCRFS1 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.8) and Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for UQCRFS1 Gene

This gene is overexpressed in Retina (6.6) and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRFS1 Gene



SOURCE GeneReport for Unigene cluster for UQCRFS1 Gene Hs.743307

genes like me logo Genes that share expression patterns with UQCRFS1: view

Protein tissue co-expression partners for UQCRFS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UQCRFS1 Gene

Orthologs for UQCRFS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UQCRFS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
UQCRFS1 35
  • 98.3 (n)
  • 97.08 (a)
cow
(Bos Taurus)
Mammalia UQCRFS1 35
  • 84.88 (n)
  • 82.9 (a)
UQCRFS1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UQCRFS1 36
  • 88 (a)
OneToOne
UQCRFS1 35
  • 87.23 (n)
  • 87.59 (a)
mouse
(Mus musculus)
Mammalia Uqcrfs1 36
  • 89 (a)
OneToOne
Uqcrfs1 16
Uqcrfs1 35
  • 84.67 (n)
  • 88.69 (a)
oppossum
(Monodelphis domestica)
Mammalia UQCRFS1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UQCRFS1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uqcrfs1 35
  • 85.89 (n)
  • 89.78 (a)
chicken
(Gallus gallus)
Aves UQCRFS1 35
  • 73.9 (n)
  • 75 (a)
UQCRFS1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UQCRFS1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia uqcrfs1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76317 35
uqcrfs1 35
  • 69.23 (n)
  • 76.92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9102 35
zebrafish
(Danio rerio)
Actinopterygii uqcrfs1 36
  • 69 (a)
OneToMany
uqcrfs1 36
  • 69 (a)
OneToMany
uqcrfs1 35
  • 65.93 (n)
  • 69.6 (a)
wufb05d11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008955 35
  • 58.3 (n)
  • 59.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta RFeSP 35
  • 62.22 (n)
  • 69.23 (a)
RFeSP 37
  • 61 (a)
RFeSP 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea isp-1 35
  • 51.5 (n)
  • 50.38 (a)
isp-1 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL067W 35
  • 59.36 (n)
  • 59.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIP1 36
  • 49 (a)
OneToOne
RIP1 38
RIP1 35
  • 59.06 (n)
  • 55.98 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22573g 35
  • 58.77 (n)
  • 54.74 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.689 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13440 35
  • 56.43 (n)
  • 52.41 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3657 35
rice
(Oryza sativa)
Liliopsida Os.6327 35
Os04g0398500 35
  • 53.41 (n)
  • 54.22 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13252 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06606 35
  • 57.64 (n)
  • 58.01 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rip1 35
  • 58.1 (n)
  • 58.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5246 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10532 36
  • 49 (a)
OneToOne
Species with no ortholog for UQCRFS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UQCRFS1 Gene

ENSEMBL:
Gene Tree for UQCRFS1 (if available)
TreeFam:
Gene Tree for UQCRFS1 (if available)

Paralogs for UQCRFS1 Gene

(2) SIMAP similar genes for UQCRFS1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for UQCRFS1 Gene

genes like me logo Genes that share paralogs with UQCRFS1: view

No data available for Paralogs for UQCRFS1 Gene

Variants for UQCRFS1 Gene

Sequence variations from dbSNP and Humsavar for UQCRFS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_051863 -
rs9304664 -- 29,207,000(+) AATGC(A/C)TCATT downstream-variant-500B
rs10403575 -- 29,207,315(+) AGACA(C/T)TGTAC utr-variant-3-prime
rs11419465 -- 29,211,184(+) AAAAA(-/A)CAAAC intron-variant
rs76009966 -- 29,209,160(+) AAATA(A/T)CTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UQCRFS1 Gene

Variant ID Type Subtype PubMed ID
dgv3837n71 CNV Gain 21882294
nsv2452 CNV Insertion 18451855

Variation tolerance for UQCRFS1 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UQCRFS1 Gene

HapMap Linkage Disequilibrium report
UQCRFS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCRFS1 Gene

Disorders for UQCRFS1 Gene

Relevant External Links for UQCRFS1

Genetic Association Database (GAD)
UQCRFS1
Human Genome Epidemiology (HuGE) Navigator
UQCRFS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UQCRFS1

No disorders were found for UQCRFS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCRFS1 Gene

Publications for UQCRFS1 Gene

  1. Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples. (PMID: 15047214) Ohashi Y. … Young S.R. (Gynecol. Oncol. 2004) 3 23 48 67
  2. Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome. (PMID: 8088805) Duncan A.M. … Rozen R. (Genomics 1994) 2 3 23
  3. The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis. (PMID: 2158323) Nishikimi M. … Ozawa T. (Biochem. Int. 1990) 3 23
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3

Products for UQCRFS1 Gene

Sources for UQCRFS1 Gene

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