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Aliases for UQCRFS1 Gene

Aliases for UQCRFS1 Gene

  • Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 2 3
  • Cytochrome B-C1 Complex Subunit 5 2 3 4
  • Ubiquinol-Cytochrome C Reductase Iron-Sulfur Subunit 3 4
  • Rieske Iron-Sulfur Protein 3 4
  • Complex III Subunit 5 3 4
  • EC 1.10.2.2 4 63
  • RISP 3 4
  • UQCR5 3
  • RIP1 3
  • RIS1 3

External Ids for UQCRFS1 Gene

Previous GeneCards Identifiers for UQCRFS1 Gene

  • GC19M030318
  • GC19M030147
  • GC19M034374
  • GC19M034390
  • GC19M029698

Summaries for UQCRFS1 Gene

GeneCards Summary for UQCRFS1 Gene

UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Alzheimers disease. GO annotations related to this gene include oxidoreductase activity and 2 iron, 2 sulfur cluster binding.

UniProtKB/Swiss-Prot for UQCRFS1 Gene

  • Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis

  • The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex.

Gene Wiki entry for UQCRFS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRFS1 Gene

Genomics for UQCRFS1 Gene

Regulatory Elements for UQCRFS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UQCRFS1 Gene

Chromosome:
19
Start:
29,205,321 bp from pter
End:
29,213,541 bp from pter
Size:
8,221 bases
Orientation:
Minus strand

Genomic View for UQCRFS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for UQCRFS1 Gene

Proteins for UQCRFS1 Gene

  • Protein details for UQCRFS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47985-UCRI_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit Rieske, mitochondrial
    Protein Accession:
    P47985
    Secondary Accessions:
    • A8K519
    • Q6NVX5
    • Q9UPH2

    Protein attributes for UQCRFS1 Gene

    Size:
    274 amino acids
    Molecular mass:
    29668 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Note=Binds 1 [2Fe-2S] cluster per subunit.;
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
    Miscellaneous:
    • The Rieske protein is a high potential 2Fe-2S protein

neXtProt entry for UQCRFS1 Gene

Proteomics data for UQCRFS1 Gene at MOPED

Post-translational modifications for UQCRFS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UQCRFS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for UQCRFS1 Gene

Suggested Antigen Peptide Sequences for UQCRFS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47985

UniProtKB/Swiss-Prot:

UCRI_HUMAN :
  • Contains 1 Rieske domain.
Domain:
  • Contains 1 Rieske domain.
genes like me logo Genes that share domains with UQCRFS1: view

Function for UQCRFS1 Gene

Molecular function for UQCRFS1 Gene

GENATLAS Biochemistry:
Rieske iron sulfur protein 1,subunit of cytochrome bc1 complex III,mitochondrial respiratory chain,oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot CatalyticActivity:
Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+)
UniProtKB/Swiss-Prot Function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UniProtKB/Swiss-Prot Function:
The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex.

Enzyme Numbers (IUBMB) for UQCRFS1 Gene

Gene Ontology (GO) - Molecular Function for UQCRFS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008121 ubiquinol-cytochrome-c reductase activity IEA --
GO:0016491 oxidoreductase activity --
GO:0032403 protein complex binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with UQCRFS1: view
genes like me logo Genes that share phenotypes with UQCRFS1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UQCRFS1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UQCRFS1 Gene

Localization for UQCRFS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRFS1 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCRFS1 Gene COMPARTMENTS Subcellular localization image for UQCRFS1 gene
Compartment Confidence
mitochondrion 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for UQCRFS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005750 mitochondrial respiratory chain complex III IEA --
GO:0031966 mitochondrial membrane --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with UQCRFS1: view

Pathways & Interactions for UQCRFS1 Gene

genes like me logo Genes that share pathways with UQCRFS1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for UQCRFS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009725 response to hormone IEA --
GO:0022904 respiratory electron transport chain TAS --
GO:0042493 response to drug IEA --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with UQCRFS1: view

No data available for SIGNOR curated interactions for UQCRFS1 Gene

Drugs & Compounds for UQCRFS1 Gene

(13) Drugs for UQCRFS1 Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE Experimental Pharma Target 0

(7) Additional Compounds for UQCRFS1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
Iron-sulfur
genes like me logo Genes that share compounds with UQCRFS1: view

Transcripts for UQCRFS1 Gene

mRNA/cDNA for UQCRFS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(427) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UQCRFS1 Gene

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UQCRFS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRFS1 Gene

No ASD Table

Relevant External Links for UQCRFS1 Gene

GeneLoc Exon Structure for
UQCRFS1
ECgene alternative splicing isoforms for
UQCRFS1

Expression for UQCRFS1 Gene

mRNA expression in normal human tissues for UQCRFS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCRFS1 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.8) and Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for UQCRFS1 Gene

This gene is overexpressed in Retina (6.6) and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRFS1 Gene



SOURCE GeneReport for Unigene cluster for UQCRFS1 Gene Hs.743307

genes like me logo Genes that share expression patterns with UQCRFS1: view

Protein tissue co-expression partners for UQCRFS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UQCRFS1 Gene

Orthologs for UQCRFS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UQCRFS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UQCRFS1 35
  • 84.88 (n)
  • 82.9 (a)
UQCRFS1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UQCRFS1 35
  • 87.23 (n)
  • 87.59 (a)
UQCRFS1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uqcrfs1 35
  • 84.67 (n)
  • 88.69 (a)
Uqcrfs1 16
Uqcrfs1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UQCRFS1 35
  • 98.3 (n)
  • 97.08 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Uqcrfs1 35
  • 85.89 (n)
  • 89.78 (a)
oppossum
(Monodelphis domestica)
Mammalia UQCRFS1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UQCRFS1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves UQCRFS1 35
  • 73.9 (n)
  • 75 (a)
UQCRFS1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UQCRFS1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76317 35
uqcrfs1 35
  • 69.23 (n)
  • 76.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia uqcrfs1-prov 35
zebrafish
(Danio rerio)
Actinopterygii uqcrfs1 35
  • 65.93 (n)
  • 69.6 (a)
wufb05d11 35
uqcrfs1 36
  • 69 (a)
OneToMany
uqcrfs1 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9102 35
fruit fly
(Drosophila melanogaster)
Insecta RFeSP 37
  • 61 (a)
RFeSP 35
  • 62.22 (n)
  • 69.23 (a)
RFeSP 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008955 35
  • 58.3 (n)
  • 59.36 (a)
worm
(Caenorhabditis elegans)
Secernentea isp-1 35
  • 51.5 (n)
  • 50.38 (a)
isp-1 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL067W 35
  • 59.36 (n)
  • 59.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22573g 35
  • 58.77 (n)
  • 54.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIP1 35
  • 59.06 (n)
  • 55.98 (a)
RIP1 36
  • 49 (a)
OneToOne
RIP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13440 35
  • 56.43 (n)
  • 52.41 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.689 35
barley
(Hordeum vulgare)
Liliopsida Hv.3657 35
rice
(Oryza sativa)
Liliopsida Os.6327 35
Os04g0398500 35
  • 53.41 (n)
  • 54.22 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13252 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5246 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06606 35
  • 57.64 (n)
  • 58.01 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rip1 35
  • 58.1 (n)
  • 58.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10532 36
  • 49 (a)
OneToOne
Species with no ortholog for UQCRFS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UQCRFS1 Gene

ENSEMBL:
Gene Tree for UQCRFS1 (if available)
TreeFam:
Gene Tree for UQCRFS1 (if available)

Paralogs for UQCRFS1 Gene

(2) SIMAP similar genes for UQCRFS1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for UQCRFS1 Gene

genes like me logo Genes that share paralogs with UQCRFS1: view

No data available for Paralogs for UQCRFS1 Gene

Variants for UQCRFS1 Gene

Sequence variations from dbSNP and Humsavar for UQCRFS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7852 -- 29,207,539(-) ACTTG(A/G)ACTCA utr-variant-3-prime
rs14596 -- 29,207,518(-) TTCTT(A/T)CAGTC utr-variant-3-prime
rs6509299 -- 29,208,713(+) TGATA(C/T)AATAA intron-variant
rs6509300 -- 29,208,870(+) CTGCA(A/G)AAGAA intron-variant
rs8106350 -- 29,211,044(+) aatga(C/T)tgcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UQCRFS1 Gene

Variant ID Type Subtype PubMed ID
dgv3837n71 CNV Gain 21882294
nsv2452 CNV Insertion 18451855

Variation tolerance for UQCRFS1 Gene

Residual Variation Intolerance Score: 53.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UQCRFS1 Gene

HapMap Linkage Disequilibrium report
UQCRFS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCRFS1 Gene

Disorders for UQCRFS1 Gene

Relevant External Links for UQCRFS1

Genetic Association Database (GAD)
UQCRFS1
Human Genome Epidemiology (HuGE) Navigator
UQCRFS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UQCRFS1
genes like me logo Genes that share disorders with UQCRFS1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCRFS1 Gene

Publications for UQCRFS1 Gene

  1. Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome. (PMID: 8088805) Duncan A.M. … Rozen R. (Genomics 1994) 2 23 67
  2. Modulation of the mitochondrial cytochrome bc1 complex activity by chromanols and related compounds. (PMID: 20014750) MA1llebner A. … Gille L. (Chem. Res. Toxicol. 2010) 23 67
  3. Redox potential of the Rieske iron-sulfur protein quantum-chemical and electrostatic study. (PMID: 20026009) Kuznetsov A.M. … Krishtalik L.I. (Biochim. Biophys. Acta 2010) 23 67
  4. Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones. (PMID: 19660431) Hughes L.M. … Trumpower B.L. (Biochim. Biophys. Acta 2010) 23 67
  5. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. (PMID: 19562034) Arsham A.M. … Neufeld T.P. (PLoS ONE 2009) 23 67

Products for UQCRFS1 Gene

Sources for UQCRFS1 Gene

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