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UQCRFS1 Gene

protein-coding   GIFtS: 62
GCID: GC19M029698

Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide...

  Search for UQCRFS1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 11 2     EC 1.10.2.23 8
Cytochrome B-C1 Complex Subunit 51 2 3     RIP12
Complex III Subunit 52 3     RIS12
Ubiquinol-Cytochrome C Reductase Iron-Sulfur Subunit2 3     UQCR52
RISP2 3     Cytochrome B-C1 Complex Subunit Rieske, Mitochondrial2
Rieske Iron-Sulfur Protein2 3     

External Ids:    HGNC: 125871   Entrez Gene: 73862   Ensembl: ENSG000001690217   OMIM: 1913275   UniProtKB: P479853   

Export aliases for UQCRFS1 gene to outside databases

Previous GC identifers: GC19M030318 GC19M030147 GC19M034374 GC19M034390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UQCRFS1 Gene:
UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) is a protein-coding gene. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity and protein complex binding.

UniProtKB/Swiss-Prot: UCRI_HUMAN, P47985
Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex),
which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Function: The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be
the subunit 11/IX of that complex (By similarity)

Gene Wiki entry for UQCRFS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the UQCRFS1 gene promoter:
         FOXD3   IRF-1   CUTL1   GATA-2   RORalpha1   Pax-3   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUQCRFS1 promoter sequence
   Search Chromatin IP Primers for UQCRFS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UQCRFS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q12

UQCRFS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UQCRFS1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M029698:  view genomic region     (about GC identifiers)

Start:
29,698,167 bp from pter      End:
29,704,448 bp from pter
Size:
6,282 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UCRI_HUMAN, P47985 (See protein sequence)
Recommended Name: Cytochrome b-c1 complex subunit Rieske, mitochondrial precursor  
Size: 274 amino acids; 29668 Da
Cofactor: Binds 1 2Fe-2S cluster per subunit (By similarity)
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Miscellaneous: The Rieske protein is a high potential 2Fe-2S protein
Secondary accessions: A8K519 Q6NVX5 Q9UPH2

Explore the universe of human proteins at neXtProt for UQCRFS1: NX_P47985

Explore proteomics data for UQCRFS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys163, Lys168
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UQCRFS1 (P47985) (see all 15)
     RPLVASV  YEFTSDD  GPAPLNL  NLEVPTY 


    See UQCRFS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005994.2  
    ENSEMBL proteins: 
     ENSP00000306397  
    Reactome Protein details: P47985

    UQCRFS1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for UQCRFS1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIII: Mitochondrial respiratory chain complex / Complex III

    Selected InterPro protein domains (see all 7):
     IPR017941 Rieske_2Fe-2S
     IPR006317 Ubiquinol_cyt_c_Rdtase_Fe-S-su
     IPR015248 Ubiqinol_cyt_c_Rdtase_N
     IPR005805 Rieske_Fe-S_prot_C
     IPR014349 Rieske_Fe-S_prot

    Graphical View of Domain Structure for InterPro Entry P47985

    ProtoNet protein and cluster: P47985

    3 Blocks protein domains:
    IPB004192 Ubiquinol cytochrome reductase transmembrane region
    IPB005806 Rieske [2Fe-2S] domain
    IPB011070 Globular protein


    UniProtKB/Swiss-Prot: UCRI_HUMAN, P47985
    Similarity: Contains 1 Rieske domain


    Find genes that share domains with UQCRFS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCRI_HUMAN, P47985
    Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex),
    which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
    Function: The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be
    the subunit 11/IX of that complex (By similarity)
    Catalytic activity: Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+)

         Genatlas biochemistry entry for UQCRFS1:
    Rieske iron sulfur protein 1,subunit of cytochrome bc1 complex III,mitochondrial respiratory chain,oxidative
    phosphorylation (OXPHOS)

         Enzyme Number (IUBMB): EC 1.10.2.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008121ubiquinol-cytochrome-c reductase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0032403protein complex binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with UQCRFS1           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Uqcrfs1):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  integument 
     mortality/aging  nervous system  pigmentation 

    Find genes that share phenotypes with UQCRFS1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UQCRFS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UQCRFS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UQCRFS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UQCRFS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UQCRFS1:
    hsa-mir-615-3p (MIRT039761), hsa-mir-106b-5p (MIRT044309), hsa-mir-155-5p (MIRT006517), hsa-mir-17-5p (MIRT050913)

    Block miRNA regulation of human, mouse, rat UQCRFS1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UQCRFS1:
    hsa-miR-33a* hsa-miR-607 hsa-miR-4272 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidUQCRFS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UQCRFS1
    Predesigned siRNA for gene silencing in human, mouse, rat UQCRFS1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: UQCRFS1 (NM_006003)
    Sino Biological Human cDNA Clone for UQCRFS1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRFS1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRFS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UCRI_HUMAN, P47985: Mitochondrion inner membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005750mitochondrial respiratory chain complex III IEA--
    GO:0016021integral component of membrane ----
    GO:0031966mitochondrial membrane ----

    Find genes that share ontologies with UQCRFS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UQCRFS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction


    Find genes that share SuperPaths with UQCRFS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for UQCRFS1
        Electron Transport Chain


    1 Reactome Pathway for UQCRFS1
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for UQCRFS1) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UQCRFS1: 
              Mitochondrial Energy Metabolism in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UQCRFS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UQCRFS1 (P479852, 3 ENSP000003063974) via UniProtKB, MINT, STRING, and/or I2D (see all 413)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH18A1P548862, 3MINT-8079030 I2D: score=1 
    GRPEL1Q9HAV72, 3MINT-8079030 I2D: score=1 
    SLC25A10Q9UBX32, 3MINT-8079030 I2D: score=1 
    UQCRC1P319302, 3, ENSP000002034074MINT-8079030 I2D: score=1 STRING: ENSP00000203407
    YME1L1Q96TA22, 3, ENSP000003184804MINT-8079030 I2D: score=1 STRING: ENSP00000318480
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009725response to hormone IEA--
    GO:0022904respiratory electron transport chain TAS--
    GO:0042493response to drug IEA--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with UQCRFS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UQCRFS1 (UCRI)

    4 HMDB Compounds for UQCRFS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    9 DrugBank Compounds for UQCRFS1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    UBIQUINONE-2-- --target--10592235

    7 Novoseek inferred chemical compound relationships for UQCRFS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron-sulfur 94.2 62 1847390 (3), 11361137 (3), 10704220 (2), 17502946 (2) (see all 48)
    ubiquinol 88.2 10 11361137 (1), 2177322 (1), 10512801 (1), 19660431 (1) (see all 10)
    hydroquinone 65.1 5 10625447 (1), 10512801 (1), 15157909 (1), 12672829 (1)
    ubiquinone 64.3 1 16005845 (1)
    quinone 39.9 1 10416018 (1)
    hydrogen 29.6 3 15449929 (1), 17223530 (1), 16830148 (1)
    histidine 24.7 2 15449929 (1), 10416018 (1)



    Find genes that share compounds with UQCRFS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UQCRFS1 gene: 
    NM_006003.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304863(uc002nsd.2)
    miRNA
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    hsa-miR-33a* hsa-miR-607 hsa-miR-4272 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidUQCRFS1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UQCRFS1
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    GenScript: all cDNA clones in your preferred vector: UQCRFS1 (NM_006003)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRFS1
    Primer
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    OriGene qPCR primer pairs and template standards for UQCRFS1
    OriGene qSTAR qPCR primer pairs in human, mouse for UQCRFS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UQCRFS1
      QuantiTect SYBR Green Assays in human, mouse, rat UQCRFS1
      QuantiFast Probe-based Assays in human, mouse, rat UQCRFS1

    Selected AceView cDNA sequences (see all 427):

    AJ346482 AW162216 BE394775 BM680526 CR592326 F26852 AI202816 CD365046 
    BU631615 BG756905 AA406265 AA805692 BQ349032 CR601299 CB110555 BU620833 
    BQ574083 BG026011 N77880 AI937378 AA917089 AI741407 AI183576 AI284780 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UQCRFS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCACACTA
    UQCRFS1 Expression
    About this image


    UQCRFS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Adrenal Gland (Endocrine System)
    UQCRFS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UQCRFS1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including UQCRFS1: 
              Mitochondrial Energy Metabolism in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UQCRFS1
    OriGene qSTAR qPCR primer pairs in human, mouse for UQCRFS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UQCRFS1
    QuantiTect SYBR Green Assays in human, mouse, rat UQCRFS1
    QuantiFast Probe-based Assays in human, mouse, rat UQCRFS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRFS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UQCRFS1 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uqcrfs11 , 5 ubiquinol-cytochrome c reductase, Rieske iron-sulfur more1, 5 84.67(n)1
    88.69(a)1
      13 (13.23 cM)5
    666941  NM_025710.21  NP_079986.11 
     305403085 
    chicken
    (Gallus gallus)
    Aves UQCRFS11 ubiquinol-cytochrome c reductase, Rieske iron-sulfur more 73.9(n)
    75(a)
      415752  NM_001005843.1  NP_001005843.1 
    lizard
    (Anolis carolinensis)
    Reptilia UQCRFS16
    ubiquinol-cytochrome c reductase, Rieske iron-sulf...
    76(a)
    1 ↔ 1
    GL343441.1(47252-55158)
    African clawed frog
    (Xenopus laevis)
    Amphibia uqcrfs1-prov2 ubiquinol-cytochrome c reductase, Rieske iron-sulfur more 79.49(n)    BC041528.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb05d112 Danio rerio cDNA clone MGC73109 IMAGE4786975, complete more 78.18(n)    BC059475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RFeSP1 , 3 Rieske iron-sulfur protein1 61(a)3
    62.22(n)1
    69.23(a)1
      22A33
    443901  NM_164426.31  NP_722715.11 
    worm
    (Caenorhabditis elegans)
    Secernentea isp-11 isp-1 51.5(n)
    50.38(a)
      177609  NM_068960.3  NP_501361.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RIP1(YEL024W)4
    RIP11
    Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur more4
    RIP11
    59.06(n)1
    55.98(a)1
      5(107260-107907)4
    8566891, 4  NP_010890.31  NP_010890.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G134401 AT5G13440 56.43(n)
    52.41(a)
      831185  NM_121347.3  NP_196848.1 
    rice
    (Oryza sativa)
    Liliopsida Os.63272 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.24(n)    AK102815.1 


    ENSEMBL Gene Tree for UQCRFS1 (if available)
    TreeFam Gene Tree for UQCRFS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UQCRFS1 gene
    2 SIMAP similar genes for UQCRFS1 using alignment to 1 protein entry:     UCRI_HUMAN:
    UQCRFS1P1    LOC202789

    Find genes that share paralogs with UQCRFS1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for UQCRFS1
    PGOHUM00000243071 PGOHUM00000233591


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UQCRFS1 (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440046761,2
    --29697744(+) TCATTC/TTGGAA 1 -- ds50010--------
    rs1903772691,2
    --29697829(+) ACTAAC/TAAAAT 1 -- ds50010--------
    rs1822026211,2
    --29697869(+) CAGCAC/GACCAG 1 -- ds50010--------
    rs1506557361,2
    C--29697876(+) CCAGAC/TGTGAA 1 -- ds50010--------
    rs93046641,2
    C,F,A,H--29697907(+) AATGCA/CTCATT 1 -- ds5001108Minor allele frequency- C:0.47NS NA EA PA EU CA WA CSA 6426
    rs1400115151,2
    --29697959(+) GCTTAC/TACAGT 1 -- ds50010--------
    rs1872118511,2
    --29698063(+) TGACCC/TGTTAA 1 -- ds50010--------
    rs104035751,2
    C,F--29698222(+) AGACAT/CTGTAC 1 -- ut31 ese37Minor allele frequency- C:0.06NA WA 266
    rs1498431101,2
    C--29698232(+) CCTTTC/TGCGTG 1 -- ut310--------
    rs1889328881,2
    --29698252(+) GCATAA/CCAGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UQCRFS1 (29698167 - 29704448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for UQCRFS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2452CNV Insertion18451855
    dgv3837n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UQCRFS1
    DNA2.0 Custom Variant and Variant Library Synthesis for UQCRFS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191327    OMIM disorders: --


    Find genes that share disorders with UQCRFS1           About GenesLikeMe

    Genetic Association Database (GAD): UQCRFS1
    Human Genome Epidemiology (HuGE) Navigator: UQCRFS1 (3 documents)

    Export disorders for UQCRFS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UQCRFS1 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with UQCRFS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples. (PubMed id 15047214)1, 4, 9 Ohashi Y....Young S.R. (Gynecol. Oncol. 2004)
    2. Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome. (PubMed id 8088805)1, 3, 9 Duncan A.M....Rozen R. (Genomics 1994)
    3. The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis. (PubMed id 2158323)1, 2, 9 Nishikimi M.... Ozawa T. (Biochem. Int. 1990)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Renal cell carcinoma and normal kidney protein expression. (PubMed id 9150947)1, 2 Sarto C.... Mocarelli P. (Electrophoresis 1997)
    10. Structure, sequence and location of the UQCRFS1 gene for the human Rieske Fe-S protein. (PubMed id 7721092)1, 2 Pennacchio L....Lennon G. (Gene 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7386 HGNC: 12587 AceView: UQCRFS1 Ensembl:ENSG00000169021 euGenes: HUgn7386
    ECgene: UQCRFS1 Kegg: 7386 H-InvDB: UQCRFS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UQCRFS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UQCRFS1 gene:
    Search GeneIP for patents involving UQCRFS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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