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Aliases for UQCRFS1 Gene

Aliases for UQCRFS1 Gene

  • Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 2 3
  • Cytochrome B-C1 Complex Subunit 5 2 3 4
  • Ubiquinol-Cytochrome C Reductase Iron-Sulfur Subunit 3 4
  • Rieske Iron-Sulfur Protein 3 4
  • Complex III Subunit 5 3 4
  • EC 1.10.2.2 4 64
  • RISP 3 4
  • Cytochrome B-C1 Complex Subunit Rieske, Mitochondrial 3
  • UQCR5 3
  • RIP1 3
  • RIS1 3

External Ids for UQCRFS1 Gene

Summaries for UQCRFS1 Gene

GeneCards Summary for UQCRFS1 Gene

UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein complex binding and ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot for UQCRFS1 Gene

  • Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis

  • The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex.

Gene Wiki entry for UQCRFS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRFS1 Gene

Genomics for UQCRFS1 Gene

Genomic Location for UQCRFS1 Gene

Start:
29,205,321 bp from pter
End:
29,213,541 bp from pter
Size:
8,221 bases
Orientation:
Minus strand

Genomic View for UQCRFS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UQCRFS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCRFS1 Gene

Regulatory Elements for UQCRFS1 Gene

Proteins for UQCRFS1 Gene

  • Protein details for UQCRFS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47985-UCRI_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit Rieske, mitochondrial
    Protein Accession:
    P47985
    Secondary Accessions:
    • A8K519
    • Q6NVX5
    • Q9UPH2

    Protein attributes for UQCRFS1 Gene

    Size:
    274 amino acids
    Molecular mass:
    29668 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Note=Binds 1 [2Fe-2S] cluster per subunit.;
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
    Miscellaneous:
    • The Rieske protein is a high potential 2Fe-2S protein

neXtProt entry for UQCRFS1 Gene

Proteomics data for UQCRFS1 Gene at MOPED

Post-translational modifications for UQCRFS1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys163 and Lys168

Other Protein References for UQCRFS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UQCRFS1 Gene

Gene Families for UQCRFS1 Gene

HGNC:
  • comIII :Mitochondrial respiratory chain complex / Complex III

UniProtKB/Swiss-Prot:

UCRI_HUMAN
Domain:
  • Contains 1 Rieske domain.:
    • P47985
genes like me logo Genes that share domains with UQCRFS1: view

Function for UQCRFS1 Gene

Molecular function for UQCRFS1 Gene

GENATLAS Biochemistry: Rieske iron sulfur protein 1,subunit of cytochrome bc1 complex III,mitochondrial respiratory chain,oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot CatalyticActivity: Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+)
UniProtKB/Swiss-Prot Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UniProtKB/Swiss-Prot Function: The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex.

Enzyme Numbers (IUBMB) for UQCRFS1 Gene

Gene Ontology (GO) - Molecular Function for UQCRFS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008121 ubiquinol-cytochrome-c reductase activity IEA --
GO:0016491 oxidoreductase activity --
GO:0032403 protein complex binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with UQCRFS1: view
genes like me logo Genes that share phenotypes with UQCRFS1: view

miRNA for UQCRFS1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UQCRFS1 Gene

Localization for UQCRFS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRFS1 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCRFS1 Gene COMPARTMENTS Subcellular localization image for UQCRFS1 gene
Compartment Confidence
mitochondrion 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for UQCRFS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005750 mitochondrial respiratory chain complex III IEA --
GO:0031966 mitochondrial membrane --
genes like me logo Genes that share ontologies with UQCRFS1: view

Pathways for UQCRFS1 Gene

genes like me logo Genes that share pathways with UQCRFS1: view

Gene Ontology (GO) - Biological Process for UQCRFS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009725 response to hormone IEA --
GO:0022904 respiratory electron transport chain TAS --
GO:0042493 response to drug IEA --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with UQCRFS1: view

Compounds for UQCRFS1 Gene

(4) HMDB Compounds for UQCRFS1 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6
QH2
  • CoQH2
56275-39-9
Ubiquinone Q1
  • Coenzyme Q
727-81-1
Ubiquinone Q2
  • 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
606-06-4

(7) Novoseek inferred chemical compound relationships for UQCRFS1 Gene

Compound -log(P) Hits PubMed IDs
iron-sulfur 94.2 60
ubiquinol 88.2 10
hydroquinone 65.1 4
ubiquinone 64.3 1
quinone 39.9 1
genes like me logo Genes that share compounds with UQCRFS1: view

Transcripts for UQCRFS1 Gene

mRNA/cDNA for UQCRFS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(427) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UQCRFS1 Gene

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRFS1 Gene

No ASD Table

Relevant External Links for UQCRFS1 Gene

GeneLoc Exon Structure for
UQCRFS1
ECgene alternative splicing isoforms for
UQCRFS1

Expression for UQCRFS1 Gene

mRNA expression in normal human tissues for UQCRFS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCRFS1 Gene

This gene is overexpressed in Heart - Left Ventricle (4.8) and Muscle - Skeletal (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRFS1 Gene

SOURCE GeneReport for Unigene cluster for UQCRFS1 Gene Hs.743307

genes like me logo Genes that share expressions with UQCRFS1: view

Orthologs for UQCRFS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UQCRFS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
UQCRFS1 36
  • 98.3 (n)
  • 97.08 (a)
cow
(Bos Taurus)
Mammalia UQCRFS1 36
  • 84.88 (n)
  • 82.9 (a)
UQCRFS1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UQCRFS1 36
  • 87.23 (n)
  • 87.59 (a)
UQCRFS1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uqcrfs1 36
  • 84.67 (n)
  • 88.69 (a)
Uqcrfs1 16
Uqcrfs1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UQCRFS1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UQCRFS1 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uqcrfs1 36
  • 85.89 (n)
  • 89.78 (a)
chicken
(Gallus gallus)
Aves UQCRFS1 36
  • 73.9 (n)
  • 75 (a)
UQCRFS1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UQCRFS1 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia uqcrfs1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76317 36
uqcrfs1 36
  • 69.23 (n)
  • 76.92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9102 36
zebrafish
(Danio rerio)
Actinopterygii uqcrfs1 36
  • 65.93 (n)
  • 69.6 (a)
uqcrfs1 37
  • 69 (a)
OneToMany
uqcrfs1 37
  • 69 (a)
OneToMany
wufb05d11 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008955 36
  • 58.3 (n)
  • 59.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta RFeSP 36
  • 62.22 (n)
  • 69.23 (a)
RFeSP 37
  • 39 (a)
OneToOne
RFeSP 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea isp-1 36
  • 51.5 (n)
  • 50.38 (a)
isp-1 37
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL067W 36
  • 59.36 (n)
  • 59.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIP1 36
  • 59.06 (n)
  • 55.98 (a)
RIP1 37
  • 49 (a)
OneToOne
RIP1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22573g 36
  • 58.77 (n)
  • 54.74 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.689 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13440 36
  • 56.43 (n)
  • 52.41 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3657 36
rice
(Oryza sativa)
Liliopsida Os.6327 36
Os04g0398500 36
  • 53.41 (n)
  • 54.22 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13252 36
bread mold
(Neurospora crassa)
Ascomycetes NCU06606 36
  • 57.64 (n)
  • 58.01 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rip1 36
  • 58.1 (n)
  • 58.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5246 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10532 37
  • 49 (a)
OneToOne
Species with no ortholog for UQCRFS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UQCRFS1 Gene

ENSEMBL:
Gene Tree for UQCRFS1 (if available)
TreeFam:
Gene Tree for UQCRFS1 (if available)

Paralogs for UQCRFS1 Gene

Selected SIMAP similar genes for UQCRFS1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for UQCRFS1 Gene

genes like me logo Genes that share paralogs with UQCRFS1: view

No data available for Paralogs for UQCRFS1 Gene

Variants for UQCRFS1 Gene

Sequence variations from dbSNP and Humsavar for UQCRFS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7852 -- 29,207,539(-) ACTTG(A/G)ACTCA utr-variant-3-prime
rs3760840 -- 29,215,205(-) TACAT(A/G)TATTA upstream-variant-2KB
rs3760841 -- 29,214,876(-) AATGT(C/T)TTTTA upstream-variant-2KB
rs4804868 -- 29,214,138(+) TGAGC(A/C)AATTC upstream-variant-2KB
rs4804869 -- 29,214,142(+) CAAAT(G/T)CACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UQCRFS1 Gene

Variant ID Type Subtype PubMed ID
dgv3837n71 CNV Gain 21882294
nsv2452 CNV Insertion 18451855

Relevant External Links for UQCRFS1 Gene

HapMap Linkage Disequilibrium report
UQCRFS1

Disorders for UQCRFS1 Gene

Relevant External Links for UQCRFS1

Genetic Association Database (GAD)
UQCRFS1
Human Genome Epidemiology (HuGE) Navigator
UQCRFS1
genes like me logo Genes that share disorders with UQCRFS1: view

No data available for UniProtKB/Swiss-Prot for UQCRFS1 Gene

Publications for UQCRFS1 Gene

  1. Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome. (PMID: 8088805) Duncan A.M. … Rozen R. (Genomics 1994) 2 3 23
  2. Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples. (PMID: 15047214) Ohashi Y. … Young S.R. (Gynecol. Oncol. 2004) 3 23 49
  3. The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis. (PMID: 2158323) Nishikimi M. … Ozawa T. (Biochem. Int. 1990) 3 4 23
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for UQCRFS1 Gene

Sources for UQCRFS1 Gene

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