Aliases for UQCRC2 Gene
External Ids for UQCRC2 Gene
Previous GeneCards Identifiers for UQCRC2 Gene
The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]
GeneCards Summary for UQCRC2 Gene
UQCRC2 (Ubiquinol-Cytochrome C Reductase Core Protein II) is a Protein Coding gene. Diseases associated with UQCRC2 include Mitochondrial Complex Iii Deficiency, Nuclear Type 5 and Mitochondrial Complex Iii Deficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cardiac muscle contraction. GO annotations related to this gene include protein complex binding and metalloendopeptidase activity. An important paralog of this gene is PMPCA.
UniProtKB/Swiss-Prot for UQCRC2 Gene
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.