Aliases for UQCRC1 Gene
Aliases for UQCRC1 Gene
External Ids for UQCRC1 Gene
- HGNC: 12585
- Entrez Gene: 7384
- Ensembl: ENSG00000010256
- OMIM: 191328
- UniProtKB: P31930
Previous GeneCards Identifiers for UQCRC1 Gene
- GC03M048426
- GC03M047919
- GC03M048597
- GC03M048611
- GC03M048636
Summaries for UQCRC1 Gene
GeneCards Summary for UQCRC1 Gene
UQCRC1 (Ubiquinol-Cytochrome C Reductase Core Protein I) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include ubiquitin protein ligase binding and ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is PMPCB.
UniProtKB/Swiss-Prot for UQCRC1 Gene
-
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRC1 Gene
Genomics for UQCRC1 Gene
Regulatory Elements for UQCRC1 Gene
Enhancers for UQCRC1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around UQCRC1 on UCSC Golden Path with GeneCards custom track
Promoters for UQCRC1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around UQCRC1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the UQCRC1 gene promoter:
Regulatory Element Products
Genomic Location for UQCRC1 Gene
- Chromosome:
- 3
- Start:
- 48,598,999 bp from pter
- End:
- 48,610,976 bp from pter
- Size:
- 11,978 bases
- Orientation:
- Minus strand
Genomic View for UQCRC1 Gene
Genes around UQCRC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by Ensembl
- 3p21.3 by Entrez Gene
- 3p21 by HGNC
UQCRC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UQCRC1 Gene
Proteins for UQCRC1 Gene
-
Protein details for UQCRC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31930-QCR1_HUMAN
- Recommended name:
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Protein Accession:
- P31930
- B2R7R8
- Q96DD2
Protein attributes for UQCRC1 Gene
- Size:
- 480 amino acids
- Molecular mass:
- 52646 Da
- Quaternary structure:
-
- The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Protein Expression for UQCRC1 Gene
Post-translational modifications for UQCRC1 Gene
Other Protein References for UQCRC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for UQCRC1
-
Cloud-Clone Corp. Antibodies for UQCRC1
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- antibodies-online Antibodies for UQCRC1: See all 51
- GeneTex UQCRC1 antibody for UQCRC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for UQCRC1
Protein Products
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OriGene Purified Proteins for UQCRC1
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Assay Products
- antibodies-online Kits for UQCRC1: See all 1
No data available for DME Specific Peptides for UQCRC1 Gene
Domains & Families for UQCRC1 Gene
Gene Families for UQCRC1 Gene
Protein Domains for UQCRC1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for UQCRC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31930- Family:
-
- Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.
Function for UQCRC1 Gene
Molecular function for UQCRC1 Gene
- GENATLAS Biochemistry:
- ubiquinol cytochrome c reductase,core protein 1,component of complex III of mitochondrial respiratory chain,oxidative phosphorylation (OXPHOS)
- UniProtKB/Swiss-Prot Function:
- This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IBA | -- |
Phenotypes for UQCRC1 Gene
- GenomeRNAi human phenotypes for UQCRC1:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased Salmonella enterica Typhimurium invasion
- Decreased shRNA abundance
- Decreased vesicular stomatitis virus (VSV) infection
Animal Model Products
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ViGene Biosciences lentiviral particle packaged cDNA for UQCRC1 gene
-
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CRISPR Products
-
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miRNA for UQCRC1 Gene
- miRTarBase miRNAs that target UQCRC1
miRNA Products
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Clone Products
- OriGene clones in human for UQCRC1
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Cell Line Products
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCRC1 Gene
Localization for UQCRC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for UQCRC1 Gene
- Mitochondrion inner membrane.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 3 |
No data available for Gene Ontology (GO) - Cellular Components for UQCRC1 Gene
Pathways & Interactions for UQCRC1 Gene
More details on SuperPathways for UQCRC1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
| 2 | Alzheimer's disease | ||
| 3 | Metabolism |
.38
|
|
| 4 | Cardiac muscle contraction |
Pathways by source for UQCRC1 Gene
1 BioSystems pathway for UQCRC1 Gene
7 KEGG pathways for UQCRC1 Gene
Interacting Proteins for UQCRC1 Gene
Selected Interacting proteins:
P31930-QCR1_HUMAN
ENSP00000203407
for UQCRC1 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006119 | oxidative phosphorylation | TAS | 8407948 |
| GO:0014823 | response to activity | IEA | -- |
| GO:0016485 | protein processing | IBA | -- |
| GO:0055114 | oxidation-reduction process | TAS | 8407948 |
No data available for SIGNOR curated interactions for UQCRC1 Gene
Drugs & Compounds for UQCRC1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ubiquinone-2 | Experimental | Pharma | Target | 0 | ||
| (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE | Experimental | Pharma | Target | 0 | ||
| 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol | Experimental | Pharma | Target | 0 | ||
| 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE | Experimental | Pharma | Target | 0 | ||
| 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| QH2 |
|
56275-39-9 |
|
Transcripts for UQCRC1 Gene
mRNA/cDNA for UQCRC1 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (71) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for UQCRC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for UQCRC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for UQCRC1
- GenScript: Design CRISPR guide RNA sequences for UQCRC1
miRNA Products
- Search ViGene Biosciences for UQCRC1
Clone Products
- OriGene clones in human for UQCRC1
- OriGene ORF clones in human,mouse,rat for UQCRC1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for UQCRC1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - |
Expression for UQCRC1 Gene
mRNA differential expression in normal tissues according to GTEx for UQCRC1 Gene
This gene is overexpressed in Heart - Left Ventricle (x5.9) and Muscle - Skeletal (x4.4).
This gene is overexpressed in Heart (11.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRC1 Gene
SOURCE GeneReport for Unigene cluster for UQCRC1 Gene Hs.119251
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for UQCRC1
-
OriGene qPCR primer pairs and template standards for UQCRC1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UQCRC1 Gene
Orthologs for UQCRC1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | UQCRC1 35 |
|
||
| UQCRC1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | UQCRC1 35 |
|
||
| UQCRC1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Uqcrc1 35 |
|
||
| Uqcrc1 16 |
|
||||
| Uqcrc1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | UQCRC1 35 |
|
||
| UQCRC1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Uqcrc1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | UQCRC1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | UQCRC1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | UQCRC1 35 |
|
||
| UQCRC1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | UQCRC1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.7650 35 |
|
||
| uqcrc1 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53748 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | uqcrc1 35 |
|
||
| zgc73404 35 |
|
||||
| uqcrc1 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG3731 37 |
|
|
|
| CG3731 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F56D2.1 37 |
|
|
|
| ZC410.2 37 |
|
|
|||
| ucr-1 35 |
|
||||
| mppb-1 36 |
|
ManyToMany | |||
| ucr-1 36 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MAS1 36 |
|
OneToMany | |
| COR1 38 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3431 36 |
|
OneToMany |
- Species with no ortholog for UQCRC1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for UQCRC1 Gene
(2) SIMAP similar genes for UQCRC1 Gene using alignment to 3 proteins:
Variants for UQCRC1 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs144710790 | - | 48,601,039(+) | CCACA(C/T)TGTCC | reference, missense | |
| rs17080284 | - | 48,603,627(+) | CAAGT(C/G)TGCAC | reference, missense | |
| rs8547 | -- | 48,599,076(-) | CCCCC(C/T)CCACC | utr-variant-3-prime | |
| rs9166 | -- | 48,599,074(-) | CCCCC(A/C)ACCAC | utr-variant-3-prime | |
| rs14864 | -- | 48,599,637(-) | TGGAT(A/G)TGGCC | reference, missense |
Residual Variation Intolerance Score:
29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.46;
54.97% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UQCRC1 Gene
Disorders for UQCRC1 Gene
Relevant External Links for UQCRC1
No disorders were found for UQCRC1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCRC1 Gene
Publications for UQCRC1 Gene
- Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol- cytochrome c reductase. (PMID: 8407948) Hoffman G.G. … Greenspan D.S. (J. Biol. Chem. 1993) 2 3 4 67
- Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer. (PMID: 16775426) Kulawiec M. … Singh K.K. (Cancer Biol. Ther. 2006) 3 23
- Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
- Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
Products for UQCRC1 Gene
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- antibodies-online Antibodies for UQCRC1: See all 51
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- Search antibodies-online for proteins
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- GeneTex UQCRC1 antibody for UQCRC1
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- ViGene Biosciences adenoviral particle packaged cDNA for UQCRC1 gene
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Sources for UQCRC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
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- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon