Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UQCRC1 Gene

protein-coding   GIFtS: 67
GCID: GC03M048636

Ubiquinol-Cytochrome C Reductase Core Protein I

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquinol-Cytochrome C Reductase Core Protein I1 2     D3S31912
Complex III Subunit 12 3     QCR12
Core Protein I2 3     UQCR12
Ubiquinol-Cytochrome-C Reductase Complex Core Protein 12 3     Cytochrome B-C1 Complex Subunit 1, Mitochondrial2

External Ids:    HGNC: 125851   Entrez Gene: 73842   Ensembl: ENSG000000102567   OMIM: 1913285   UniProtKB: P319303   

Export aliases for UQCRC1 gene to outside databases

Previous GC identifers: GC03M048426 GC03M047919 GC03M048597 GC03M048611


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for UQCRC1 Gene:
UQCRC1 (ubiquinol-cytochrome c reductase core protein I) is a protein-coding gene. Diseases associated with UQCRC1 include labyrinthitis, and huntington's disease. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity and protein complex binding. An important paralog of this gene is PMPCB.

UniProtKB/Swiss-Prot: QCR1_HUMAN, P31930
Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex
between cytochromes c and c1

Gene Wiki entry for UQCRC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the UQCRC1 gene promoter:
         HOXA9   GR   AP-1   GR-beta   ATF-2   MyoD   HNF-4alpha2   HNF-4alpha1   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUQCRC1 promoter sequence
   Search Chromatin IP Primers for UQCRC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UQCRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

UQCRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UQCRC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048636:  view genomic region     (about GC identifiers)

Start:
48,636,432 bp from pter      End:
48,648,409 bp from pter
Size:
11,978 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: QCR1_HUMAN, P31930 (See protein sequence)
Recommended Name: Cytochrome b-c1 complex subunit 1, mitochondrial precursor  
Size: 480 amino acids; 52646 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Caution: Does not seem to have a protease activity as it lack the zinc-binding site
Secondary accessions: B2R7R8 Q96DD2

Explore the universe of human proteins at neXtProt for UQCRC1: NX_P31930

Explore proteomics data for UQCRC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys225
  • Modification sites at PhosphoSitePlus

  • See UQCRC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003356.2  
    ENSEMBL proteins: 
     ENSP00000203407   ENSP00000393696   ENSP00000388660  
    Reactome Protein details: P31930

    UQCRC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UQCRC1
    OriGene Protein Over-expression Lysate for UQCRC1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UQCRC1
    GenScript Custom Purified and Recombinant Proteins Services for UQCRC1
    Novus Biologicals UQCRC1 Protein
    Novus Biologicals UQCRC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UQCRC1

    UQCRC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UQCRC1
    OriGene Custom Antibody Services for UQCRC1
    Novus Biologicals UQCRC1 Antibodies
    Abcam antibodies for UQCRC1
    Cloud-Clone Corp. Antibodies for UQCRC1
    ThermoFisher Antibodies for UQCRC1
    LSBio Antibodies in human, mouse, rat for UQCRC1

    UQCRC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UQCRC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UQCRC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UQCRC1
    Cloud-Clone Corp. CLIAs for UQCRC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    comIII: Mitochondrial respiratory chain complex / Complex III

    4 InterPro protein domains:
     IPR011765 Pept_M16_N
     IPR011237 Pept_M16_dom
     IPR007863 Peptidase_M16_C
     IPR011249 Metalloenz_LuxS/M16

    Graphical View of Domain Structure for InterPro Entry P31930

    ProtoNet protein and cluster: P31930

    1 Blocks protein domain: IPB001431 Insulinase-like peptidase

    UniProtKB/Swiss-Prot: QCR1_HUMAN, P31930
    Similarity: Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily


    UQCRC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QCR1_HUMAN, P31930
    Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
    complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex
    between cytochromes c and c1

         Genatlas biochemistry entry for UQCRC1:
    ubiquinol cytochrome c reductase,core protein 1,component of complex III of mitochondrial respiratory
    chain,oxidative phosphorylation (OXPHOS)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005515protein binding ----
    GO:0008121ubiquinol-cytochrome-c reductase activity TAS8407948
    GO:0032403protein complex binding IEA--
    GO:0046872metal ion binding IEA--
         
    UQCRC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UQCRC1:
     Decreased Salmonella enterica  

         1 MGI phenotypic allele for Uqcrc1 (no phenotypes)

    UQCRC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UQCRC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UQCRC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UQCRC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UQCRC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UQCRC1:
    hsa-mir-30c-5p (MIRT048017), hsa-mir-877-3p (MIRT036834), hsa-mir-20a-5p (MIRT050603), hsa-mir-93-5p (MIRT048908), hsa-mir-1296-5p (MIRT036152), hsa-mir-183-5p (MIRT047130), hsa-mir-320b (MIRT036243)

    Block miRNA regulation of human, mouse, rat UQCRC1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UQCRC1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UQCRC1
    Predesigned siRNA for gene silencing in human, mouse, rat UQCRC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UQCRC1

    Clone
    Products:
         
    OriGene clones in human, mouse for UQCRC1 (see all 9)
    OriGene ORF clones in mouse, rat for UQCRC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UQCRC1 (NM_003365)
    Sino Biological Human cDNA Clone for UQCRC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UQCRC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UQCRC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for UQCRC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    QCR1_HUMAN, P31930: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005746mitochondrial respiratory chain TAS8407948
    GO:0005750mitochondrial respiratory chain complex III IEA--

    UQCRC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UQCRC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for UQCRC1
        Electron Transport Chain


    1 Reactome Pathway for UQCRC1
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for UQCRC1) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    UQCRC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UQCRC1: 
              Mitochondrial Energy Metabolism in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UQCRC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UQCRC1 (P319302, 3 ENSP000002034074) via UniProtKB, MINT, STRING, and/or I2D (see all 404)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UQCRFS1P479852, 3, ENSP000003063974MINT-8079030 I2D: score=1 STRING: ENSP00000306397
    UQCRC2P226952, 3, ENSP000002683794MINT-8079030 I2D: score=4 STRING: ENSP00000268379
    TRIM63Q969Q12, 3, ENSP000003633904MINT-6503720 I2D: score=2 STRING: ENSP00000363390
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    CYCSP999993, ENSP000003077864I2D: score=3 STRING: ENSP00000307786
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006119oxidative phosphorylation TAS8407948
    GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c IEA--
    GO:0009060aerobic respiration TAS8407948
    GO:0014823response to activity IEA--
    GO:0022904respiratory electron transport chain TAS--

    UQCRC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UQCRC1 (QCR1)

    3 HMDB Compounds for UQCRC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    9 DrugBank Compounds for UQCRC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    Myxothiazol-- 76706-55-3target--10592235
    UBIQUINONE-2-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UQCRC1 gene: 
    NM_003365.2  

    Unigene Cluster for UQCRC1:

    Ubiquinol-cytochrome c reductase core protein I
    Hs.119251  [show with all ESTs]
    Unigene Representative Sequence: L16842
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471189 ENST00000203407(uc003cub.1) ENST00000480561 ENST00000415995
    ENST00000460105 ENST00000472438 ENST00000412343 ENST00000467690 ENST00000463708
    ENST00000493806

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UQCRC1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UQCRC1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UQCRC1
    Predesigned siRNA for gene silencing in human, mouse, rat UQCRC1
    Clone
    Products:
         
    OriGene clones in human, mouse for UQCRC1 (see all 9)
    OriGene ORF clones in mouse, rat for UQCRC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UQCRC1 (NM_003365)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UQCRC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRC1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UQCRC1
    OriGene qSTAR qPCR primer pairs in human, mouse for UQCRC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UQCRC1
      QuantiTect SYBR Green Assays in human, mouse, rat UQCRC1
      QuantiFast Probe-based Assays in human, mouse, rat UQCRC1

    Additional mRNA sequence: 

    AK129903.1 AK300694.1 AK302840.1 AK313090.1 BC009586.1 BC127208.1 BC127209.1 D26485.1 
    L16842.1 

    Selected DOTS entries (see all 29):

    DT.419800  DT.95184760  DT.100881541  DT.97860726  DT.95125803  DT.100881539  DT.100044968  DT.100765431 
    DT.100881554  DT.85104839  DT.95127100  DT.95127202  DT.100881562  DT.120881626  DT.75188876  DT.100759986 
    DT.100831369  DT.102835469  DT.120881575  DT.120881586  DT.91977936  DT.92464897  DT.95127096  DT.95127197 

    Selected AceView cDNA sequences (see all 71):

    BU538638 BQ063063 BM665242 BE219413 AI359223 BE044324 BX091306 BU739303 
    BM749965 BE503784 BE858103 BM712531 BQ056846 BU738328 BM714676 AW590676 
    BM674265 AI926277 BM673813 AB011536 BM555126 AW770479 BE467095 AA773736 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UQCRC1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -                                                                                               -                                 
    SP2:                    -                                                                                                                                 
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                  -                                                                                                   


    ECgene alternative splicing isoforms for UQCRC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UQCRC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGGCTGC
    UQCRC1 Expression
    About this image


    UQCRC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Kidney (Urinary System)
             Metanephros
     
     Ovary (Reproductive System)
             Oviduct
    UQCRC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UQCRC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119251
        Pathway & Disease-focused RT2 Profiler PCR Arrays including UQCRC1: 
              Mitochondrial Energy Metabolism in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UQCRC1
    OriGene qSTAR qPCR primer pairs in human, mouse for UQCRC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UQCRC1
    QuantiTect SYBR Green Assays in human, mouse, rat UQCRC1
    QuantiFast Probe-based Assays in human, mouse, rat UQCRC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UQCRC1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uqcrc11 , 5 ubiquinol-cytochrome c reductase core protein 11, 5 85.76(n)1
    88.75(a)1
      9 (59.63 cM)5
    222731  NM_025407.21  NP_079683.21 
     1089366485 
    chicken
    (Gallus gallus)
    Aves UQCRC11 ubiquinol-cytochrome c reductase core protein I 70.44(n)
    70.02(a)
      416013  XM_414356.4  XP_414356.2 
    lizard
    (Anolis carolinensis)
    Reptilia UQCRC16
    ubiquinol-cytochrome c reductase core protein I
    66(a)
    1 ↔ 1
    2(164416907-164439137)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537482 similar to ubiquinol-cytochrome c reductase core protein more 73.94(n)    BC049288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc734042 hypothetical protein MGC73404 72.98(n)   393793  BC059705.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37313 mitochondrial processing peptidase 57(a)   88D6   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZC410.23
    ucr-11
    mitochondrial processing peptidase3
    ucr-11
    43(a)
    (best of 2)3
    49.36(n)1
    40.22(a)1
      IV(9074536-9076682)3
    1757721  NM_065801.61  NP_498202.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COR1(YBL045C)4 Core subunit of the ubiquinol-cytochrome c reductase more   --   2(135516-134143) 852235  NP_009508.1 


    ENSEMBL Gene Tree for UQCRC1 (if available)
    TreeFam Gene Tree for UQCRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UQCRC1 gene
    PMPCB2  
    2 SIMAP similar genes for UQCRC1 using alignment to 3 protein entries:     QCR1_HUMAN (see all proteins):
    DKFZp586I1223    PMPCB

    UQCRC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UQCRC1 (see all 331)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494170731,2
    --48636018(+) AAGAGA/GCATCC 1 -- ds50010--------
    rs104520301,2
    C,F,H--48636099(+) GTGAGG/AGGTTT 1 -- ds50018Minor allele frequency- A:0.01NS EA NA 1088
    rs1128166231,2
    C--48636182(+) ACTCCC/TACAGC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1379425481,2
    C--48636206(+) CAGCTA/GGCTGA 1 -- ds50010--------
    rs1424236691,2
    --48636304(+) GCTTGC/TCCCTG 1 -- ds50010--------
    rs1459461641,2
    --48636357(+) AGCCAC/GAGAAC 1 -- ds50010--------
    rs1398278461,2
    --48636464(+) GGTCAC/TCTGTG 1 -- ut310--------
    rs91661,2
    C,F--48636507(-) CCCCCC/AACCAC 1 -- ut31 ese3 trp33Minor allele frequency- A:0.04MN NA EU 779
    rs85471,2
    C,F--48636509(-) CCCCCC/TCCACC 1 -- ut31 ese3 trp33Minor allele frequency- T:0.01MN NA EU 779
    rs1391741231,2
    C--48636559(+) TTCCCG/ACCTAG 1 -- ut311Minor allele frequency- A:0.00EU 1197

    HapMap Linkage Disequilibrium report for UQCRC1 (48636432 - 48648409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for UQCRC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876762CNV Loss21882294
    nsv834685CNV Loss17160897
    nsv3811CNV Loss18451855
    nsv523981CNV Loss19592680
    nsv822074CNV Gain20364138
    nsv818138CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UQCRC1
    DNA2.0 Custom Variant and Variant Library Synthesis for UQCRC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 191328    OMIM disorders: --

    15 diseases for UQCRC1:    
    About MalaCards
    labyrinthitis    huntington's disease    fatty liver disease    cystic fibrosis
    pneumonia    tonsillitis    parkinson's disease    schizophrenia
    alzheimer's disease    liver disease    tuberculosis    cerebritis
    thyroiditis    endotheliitis    prostatitis


    UQCRC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for UQCRC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 16775426 (1)

    Genetic Association Database (GAD): UQCRC1
    Human Genome Epidemiology (HuGE) Navigator: UQCRC1 (1 document)

    Export disorders for UQCRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UQCRC1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with UQCRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol- cytochrome c reductase. (PubMed id 8407948)1, 2, 3 Hoffman G.G.... Greenspan D.S. (J. Biol. Chem. 1993)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (Biochem. J. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. (PubMed id 10453733)1, 2 Valnot I.... Roetig A. (Hum. Genet. 1999)
    6. A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase. (PubMed id 8069229)1, 2 Islam M.M.... Ozawa T. (Biochem. Mol. Biol. Int. 1994)
    7. A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase. (PubMed id 7981668)1, 2 Islam M.M....Ozawa T. (Biochem. Mol. Biol. Int. 1994)
    8. A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase. (PubMed id 7951059)1, 2 Islam M.M....Ozawa T. (Biochem. Mol. Biol. Int. 1994)
    9. Human liver protein map: update 1993. (PubMed id 8313870)1, 2 Hughes G.J.... Hochstrasser D.F. (Electrophoresis 1993)
    10. Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer. (PubMed id 16775426)1, 9 Kulawiec M....Singh K.K. (amp 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7384 HGNC: 12585 AceView: UQCRC1 Ensembl:ENSG00000010256 euGenes: HUgn7384
    ECgene: UQCRC1 Kegg: 7384 H-InvDB: UQCRC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UQCRC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UQCRC1 gene:
    Search GeneIP for patents involving UQCRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UQCRC1   OriGene RNAi products in human, mouse, rat for UQCRC1  
     OriGene qPCR primer pairs and template standards for UQCRC1   OriGene Protein Over-expression Lysate for UQCRC1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UQCRC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UQCRC1   OriGene Purified Protein for UQCRC1  
     OriGene ORF clones in mouse, rat for UQCRC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UQCRC1   OriGene Custom Protein Services for UQCRC1  

     
     
     Block miRNA regulation of human, mouse, rat UQCRC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UQCRC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UQCRC1 Predesigned siRNA for gene silencing in human, mouse, rat UQCRC1
     QuantiFast Probe-based Assays in human, mouse, rat UQCRC1 QuantiTect SYBR Green Assays in human, mouse, rat UQCRC1
     PCR Arrays including human, mouse, rat UQCRC1 Search Chromatin IP Primers for UQCRC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UQCRC1  GeneGlobe Interaction Network for UQCRC1
     Regulatory tfbs in UQCRC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UQCRC1 GenScript cDNA clones with any tag delivered in your preferred vector for UQCRC1
     GenScript Custom Assay Services for UQCRC1 GenScript Custom overexpressing Cell Line Services for UQCRC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UQCRC1 (QCR1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for UQCRC1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UQCRC1 antibodies
     UQCRC1 proteins
     UQCRC1 lysates
     Antibodies for UQCRC1
     See all of Abcam's Antibodies, Kits and Proteins for UQCRC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UQCRC1
     Antibodies for UQCRC1
     ELISAs for UQCRC1
     CLIAs for UQCRC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for UQCRC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRC1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for UQCRC1
     SwitchGear Promoter luciferase reporter plasmids for UQCRC1
     ThermoFisher Antibodies for UQCRC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UQCRC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UQCRC1
     LSBio Antibodies in human, mouse, rat for UQCRC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UQCRC1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4