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Aliases for UQCRC1 Gene

Aliases for UQCRC1 Gene

  • Ubiquinol-Cytochrome C Reductase Core Protein I 2 3
  • Ubiquinol-Cytochrome-C Reductase Complex Core Protein 1 3 4
  • Complex III Subunit 1 3 4
  • Core Protein I 3 4
  • Cytochrome B-C1 Complex Subunit 1, Mitochondrial 3
  • D3S3191 3
  • UQCR1 3
  • QCR1 3

External Ids for UQCRC1 Gene

Previous GeneCards Identifiers for UQCRC1 Gene

  • GC03M048426
  • GC03M047919
  • GC03M048597
  • GC03M048611
  • GC03M048636

Summaries for UQCRC1 Gene

GeneCards Summary for UQCRC1 Gene

UQCRC1 (Ubiquinol-Cytochrome C Reductase Core Protein I) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein complex binding and ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is PMPCB.

UniProtKB/Swiss-Prot for UQCRC1 Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1

Gene Wiki entry for UQCRC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRC1 Gene

Genomics for UQCRC1 Gene

Regulatory Elements for UQCRC1 Gene

Genomic Location for UQCRC1 Gene

Start:
48,598,999 bp from pter
End:
48,610,976 bp from pter
Size:
11,978 bases
Orientation:
Minus strand

Genomic View for UQCRC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UQCRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCRC1 Gene

Proteins for UQCRC1 Gene

  • Protein details for UQCRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31930-QCR1_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 1, mitochondrial
    Protein Accession:
    P31930
    Secondary Accessions:
    • B2R7R8
    • Q96DD2

    Protein attributes for UQCRC1 Gene

    Size:
    480 amino acids
    Molecular mass:
    52646 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)

neXtProt entry for UQCRC1 Gene

Proteomics data for UQCRC1 Gene at MOPED

Post-translational modifications for UQCRC1 Gene

  • Ubiquitination at Lys225
  • Modification sites at PhosphoSitePlus

Other Protein References for UQCRC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UQCRC1 Gene

Domains for UQCRC1 Gene

Gene Families for UQCRC1 Gene

HGNC:
  • comIII :Mitochondrial respiratory chain complex / Complex III

Protein Domains for UQCRC1 Gene

Suggested Antigen Peptide Sequences for UQCRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31930

UniProtKB/Swiss-Prot:

QCR1_HUMAN :
  • P31930
Family:
  • Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.
genes like me logo Genes that share domains with UQCRC1: view

Function for UQCRC1 Gene

Molecular function for UQCRC1 Gene

GENATLAS Biochemistry: ubiquinol cytochrome c reductase,core protein 1,component of complex III of mitochondrial respiratory chain,oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1

Gene Ontology (GO) - Molecular Function for UQCRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005515 protein binding --
GO:0008121 ubiquinol-cytochrome-c reductase activity TAS 8407948
GO:0031625 ubiquitin protein ligase binding IPI 19725078
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with UQCRC1: view

Phenotypes for UQCRC1 Gene

GenomeRNAi human phenotypes for UQCRC1:
genes like me logo Genes that share phenotypes with UQCRC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UQCRC1 Gene

Localization for UQCRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRC1 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCRC1 Gene COMPARTMENTS Subcellular localization image for UQCRC1 gene
Compartment Confidence
mitochondrion 5
cytosol 3

Gene Ontology (GO) - Cellular Components for UQCRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005746 mitochondrial respiratory chain TAS 8407948
GO:0005750 mitochondrial respiratory chain complex III IEA --
genes like me logo Genes that share ontologies with UQCRC1: view

Pathways for UQCRC1 Gene

genes like me logo Genes that share pathways with UQCRC1: view

Gene Ontology (GO) - Biological Process for UQCRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006119 oxidative phosphorylation TAS 8407948
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c IEA --
GO:0009060 aerobic respiration TAS 8407948
GO:0014823 response to activity IEA --
GO:0022904 respiratory electron transport chain TAS --
genes like me logo Genes that share ontologies with UQCRC1: view

Compounds for UQCRC1 Gene

(3) HMDB Compounds for UQCRC1 Gene

Compound Synonyms Cas Number PubMed IDs
QH2
  • CoQH2
56275-39-9
Ubiquinone Q1
  • Coenzyme Q
727-81-1
Ubiquinone Q2
  • 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
606-06-4

(9) Drugbank Compounds for UQCRC1 Gene

genes like me logo Genes that share compounds with UQCRC1: view

Transcripts for UQCRC1 Gene

Unigene Clusters for UQCRC1 Gene

Ubiquinol-cytochrome c reductase core protein I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: - -

Relevant External Links for UQCRC1 Gene

GeneLoc Exon Structure for
UQCRC1
ECgene alternative splicing isoforms for
UQCRC1

Expression for UQCRC1 Gene

mRNA expression in normal human tissues for UQCRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCRC1 Gene

This gene is overexpressed in Heart - Left Ventricle (5.9) and Muscle - Skeletal (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRC1 Gene

SOURCE GeneReport for Unigene cluster for UQCRC1 Gene Hs.119251

genes like me logo Genes that share expressions with UQCRC1: view

No data available for mRNA Expression by UniProt/SwissProt for UQCRC1 Gene

Orthologs for UQCRC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UQCRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UQCRC1 35
  • 99.49 (n)
  • 100 (a)
UQCRC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UQCRC1 35
  • 86.6 (n)
  • 89.17 (a)
UQCRC1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UQCRC1 35
  • 88.82 (n)
  • 91.04 (a)
UQCRC1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uqcrc1 35
  • 85.76 (n)
  • 88.75 (a)
Uqcrc1 16
Uqcrc1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UQCRC1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UQCRC1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uqcrc1 35
  • 85.49 (n)
  • 88.12 (a)
chicken
(Gallus gallus)
Aves UQCRC1 35
  • 70.44 (n)
  • 70.02 (a)
UQCRC1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UQCRC1 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53748 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7650 35
uqcrc1 35
  • 68.48 (n)
  • 68.2 (a)
zebrafish
(Danio rerio)
Actinopterygii uqcrc1 35
  • 63.02 (n)
  • 63.95 (a)
uqcrc1 36
  • 58 (a)
OneToOne
zgc73404 35
fruit fly
(Drosophila melanogaster)
Insecta CG3731 36
  • 55 (a)
OneToMany
CG3731 37
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea mppb-1 36
  • 41 (a)
ManyToMany
ucr-1 35
  • 49.36 (n)
  • 40.22 (a)
ucr-1 36
  • 39 (a)
ManyToMany
F56D2.1 37
  • 39 (a)
ZC410.2 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COR1 38
MAS1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3431 36
  • 50 (a)
OneToMany
Species with no ortholog for UQCRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UQCRC1 Gene

ENSEMBL:
Gene Tree for UQCRC1 (if available)
TreeFam:
Gene Tree for UQCRC1 (if available)

Paralogs for UQCRC1 Gene

Paralogs for UQCRC1 Gene

Selected SIMAP similar genes for UQCRC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UQCRC1: view

Variants for UQCRC1 Gene

Sequence variations from dbSNP and Humsavar for UQCRC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8547 -- 48,599,076(-) CCCCC(C/T)CCACC utr-variant-3-prime
rs9166 -- 48,599,074(-) CCCCC(A/C)ACCAC utr-variant-3-prime
rs1803977 -- 48,599,119(-) GGAAG(C/T)CTATG utr-variant-3-prime
rs2267843 -- 48,603,774(-) TTGGG(C/G)AGTGT intron-variant
rs2311006 -- 48,607,263(+) gtctc(A/G)atctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UQCRC1 Gene

Variant ID Type Subtype PubMed ID
nsv523981 CNV Loss 19592680
nsv834685 CNV Loss 17160897
nsv876762 CNV Loss 21882294
nsv3811 CNV Loss 18451855
nsv818138 CNV Gain 17921354
nsv822074 CNV Gain 20364138

Relevant External Links for UQCRC1 Gene

HapMap Linkage Disequilibrium report
UQCRC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCRC1 Gene

Disorders for UQCRC1 Gene

(1) Novoseek inferred disease relationships for UQCRC1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for UQCRC1

Genetic Association Database (GAD)
UQCRC1
Human Genome Epidemiology (HuGE) Navigator
UQCRC1
genes like me logo Genes that share disorders with UQCRC1: view

No data available for UniProtKB/Swiss-Prot for UQCRC1 Gene

Publications for UQCRC1 Gene

  1. Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol- cytochrome c reductase. (PMID: 8407948) Hoffman G.G. … Greenspan D.S. (J. Biol. Chem. 1993) 2 3 4
  2. A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. (PMID: 10453733) Valnot I. … Roetig A. (Hum. Genet. 1999) 3 4
  3. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PMID: 15242332) Aboulaich N. … Vener A.V. (Biochem. J. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer. (PMID: 16775426) Kulawiec M. … Singh K.K. (Cancer Biol. Ther. 2006) 3 23

Products for UQCRC1 Gene

Sources for UQCRC1 Gene

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