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Aliases for UQCRB Gene

Aliases for UQCRB Gene

  • Ubiquinol-Cytochrome C Reductase Binding Protein 2 3
  • UQBP 3 4 6
  • Ubiquinol-Cytochrome C Reductase Complex 14 KDa Protein 3 4
  • Cytochrome B-C1 Complex Subunit 7 2 3
  • Complex III Subunit VII 3 4
  • Complex III Subunit 7 3 4
  • MC3DN3 3 6
  • QP-C 3 4
  • QPC 3 6
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit VI 3
  • Mitochondrial Ubiquinone-Binding Protein 3
  • Ubiquinol-Cytochrome C Reductase 2
  • Complex III Subunit VI 2
  • UQCR6 3
  • QCR7 3
  • UQBC 3
  • UQPC 3

External Ids for UQCRB Gene

Previous Symbols for UQCRB Gene

  • UQBP

Summaries for UQCRB Gene

Entrez Gene Summary for UQCRB Gene

  • This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]

GeneCards Summary for UQCRB Gene

UQCRB (Ubiquinol-Cytochrome C Reductase Binding Protein) is a Protein Coding gene. Diseases associated with UQCRB include mitochondrial complex iii deficiency, nuclear type 3 and mitochondrial respiratory chain complex iii deficiency, uqcrb-related. Among its related pathways are Metabolism and Metabolism.

UniProtKB/Swiss-Prot for UQCRB Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping

Gene Wiki entry for UQCRB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRB Gene

Genomics for UQCRB Gene

Genomic Location for UQCRB Gene

Start:
96,225,920 bp from pter
End:
96,235,634 bp from pter
Size:
9,715 bases
Orientation:
Minus strand

Genomic View for UQCRB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UQCRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCRB Gene

Regulatory Elements for UQCRB Gene

Proteins for UQCRB Gene

  • Protein details for UQCRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14927-QCR7_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 7
    Protein Accession:
    P14927
    Secondary Accessions:
    • E5RJU0
    • Q6FGD1

    Protein attributes for UQCRB Gene

    Size:
    111 amino acids
    Molecular mass:
    13530 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)

    Alternative splice isoforms for UQCRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UQCRB Gene

Proteomics data for UQCRB Gene at MOPED

Post-translational modifications for UQCRB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys12 and Lys29

Other Protein References for UQCRB Gene

No data available for DME Specific Peptides for UQCRB Gene

Domains for UQCRB Gene

Gene Families for UQCRB Gene

HGNC:
  • comIII :Mitochondrial respiratory chain complex / Complex III

Protein Domains for UQCRB Gene

UniProtKB/Swiss-Prot:

QCR7_HUMAN
Family:
  • Belongs to the UQCRB/QCR7 family.:
    • P14927
genes like me logo Genes that share domains with UQCRB: view

Function for UQCRB Gene

Molecular function for UQCRB Gene

GENATLAS Biochemistry: ubiquinol binding protein,13kDa,component of cytochrome bc1,complex III of mitochondrial respiratory chain,oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping

Gene Ontology (GO) - Molecular Function for UQCRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UQCRB: view

miRNA for UQCRB Gene

miRTarBase miRNAs that target UQCRB

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UQCRB Gene

Localization for UQCRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRB Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCRB Gene COMPARTMENTS Subcellular localization image for UQCRB gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for UQCRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005746 mitochondrial respiratory chain TAS 3056408
GO:0005750 mitochondrial respiratory chain complex III IEA --
genes like me logo Genes that share ontologies with UQCRB: view

Pathways for UQCRB Gene

genes like me logo Genes that share pathways with UQCRB: view

Gene Ontology (GO) - Biological Process for UQCRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006119 oxidative phosphorylation TAS 3056408
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c IEA --
GO:0009060 aerobic respiration TAS 3056408
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with UQCRB: view

Compounds for UQCRB Gene

(3) HMDB Compounds for UQCRB Gene

Compound Synonyms Cas Number PubMed IDs
QH2
  • CoQH2
56275-39-9
Ubiquinone Q1
  • Coenzyme Q
727-81-1
Ubiquinone Q2
  • 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
606-06-4
genes like me logo Genes that share compounds with UQCRB: view

Transcripts for UQCRB Gene

Unigene Clusters for UQCRB Gene

Ubiquinol-cytochrome c reductase binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for UQCRB Gene

GeneLoc Exon Structure for
UQCRB
ECgene alternative splicing isoforms for
UQCRB

Expression for UQCRB Gene

mRNA expression in normal human tissues for UQCRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCRB Gene

This gene is overexpressed in Heart - Left Ventricle (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRB Gene

SOURCE GeneReport for Unigene cluster for UQCRB Gene Hs.131255

genes like me logo Genes that share expressions with UQCRB: view

Orthologs for UQCRB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UQCRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UQCRB 36
  • 99.1 (n)
  • 100 (a)
UQCRB 37
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UQCRB 36
  • 89.19 (n)
  • 85.59 (a)
UQCRB 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC477944 36
  • 87.88 (n)
  • 89.09 (a)
UQCRB 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uqcrb 36
  • 88.29 (n)
  • 87.39 (a)
Uqcrb 16
Uqcrb 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UQCRB 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UQCRB 37
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves UQCRB 36
  • 73.87 (n)
  • 75.68 (a)
lizard
(Anolis carolinensis)
Reptilia UQCRB 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24179 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732809 36
  • 72.37 (n)
  • 72.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12392 36
zebrafish
(Danio rerio)
Actinopterygii Dr.3887 36
uqcrb 36
  • 68.77 (n)
  • 72.07 (a)
uqcrb 37
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012188 36
  • 59.93 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17856 36
  • 60.87 (n)
  • 65.22 (a)
CG17856 37
  • 44 (a)
OneToMany
CG3560 37
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes QCR7 37
  • 28 (a)
OneToOne
QCR7 39
Species with no ortholog for UQCRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UQCRB Gene

ENSEMBL:
Gene Tree for UQCRB (if available)
TreeFam:
Gene Tree for UQCRB (if available)

Paralogs for UQCRB Gene

Pseudogenes.org Pseudogenes for UQCRB Gene

genes like me logo Genes that share paralogs with UQCRB: view

No data available for Paralogs for UQCRB Gene

Variants for UQCRB Gene

Sequence variations from dbSNP and Humsavar for UQCRB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1056268 -- 96,231,086(-) GGAAA(A/G)AAAAG missense, reference, utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs1804263 -- 96,231,826(-) GGACC(C/T)GAACT missense, reference, nc-transcript-variant
rs2292835 -- 96,231,492(+) GCAGA(A/G)TGCAG intron-variant, reference, synonymous-codon, nc-transcript-variant
rs2292836 -- 96,227,385(+) TGTAC(A/C)CTAAG utr-variant-3-prime, nc-transcript-variant
rs7002575 -- 96,229,896(+) AATTC(A/G)TTTTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for UQCRB Gene

Variant ID Type Subtype PubMed ID
nsv6318 CNV Insertion 18451855

Relevant External Links for UQCRB Gene

HapMap Linkage Disequilibrium report
UQCRB
Human Gene Mutation Database (HGMD)
UQCRB

Disorders for UQCRB Gene

(1) OMIM Diseases for UQCRB Gene (191330)

UniProtKB/Swiss-Prot

QCR7_HUMAN
  • Mitochondrial complex III deficiency, nuclear 3 (MC3DN3) [MIM:615158]: A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. {ECO:0000269 PubMed:12709789}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for UQCRB

Genetic Association Database (GAD)
UQCRB
Human Genome Epidemiology (HuGE) Navigator
UQCRB
genes like me logo Genes that share disorders with UQCRB: view

Publications for UQCRB Gene

  1. Chromosomal assignment of the gene for the ubiquinone-binding protein of human mitochondrial cytochrome bc1 complex. (PMID: 2167087) Hosokawa Y. … Ozawa T. (Biochem. Int. 1990) 2 3 23
  2. A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis. (PMID: 12709789) Haut S. … Slama A. (Hum. Genet. 2003) 3 4 23
  3. Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain. (PMID: 2543413) Suzuki H. … Ozawa T. (Biochem. Biophys. Res. Commun. 1989) 2 3 4
  4. Cloning and sequencing of a cDNA for human mitochondrial ubiquinone- binding protein of complex III. (PMID: 3056408) Suzuki H. … Ozawa T. (Biochem. Biophys. Res. Commun. 1988) 2 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UQCRB Gene

Sources for UQCRB Gene

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