Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UQCRB Gene

protein-coding   GIFtS: 64
GCID: GC08M097311

Ubiquinol-Cytochrome C Reductase Binding Protein


(Previous symbol: UQBP)
  See UQCRB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquinol-Cytochrome C Reductase Binding Protein1 2     Complex III Subunit VI1
UQBP1 2 3 5     Ubiquinol-Cytochrome C Reductase1
Cytochrome B-C1 Complex Subunit 71 2     QCR72
Complex III Subunit 72 3     UQBC2
Complex III Subunit VII2 3     UQCR62
Ubiquinol-Cytochrome C Reductase Complex 14 KDa Protein2 3     UQPC2
QP-C2 3     Mitochondrial Ubiquinone-Binding Protein2
MC3DN32 5     Ubiquinol-Cytochrome C Reductase, Complex III Subunit VI2
QPC2 5     

External Ids:    HGNC: 125821   Entrez Gene: 73812   Ensembl: ENSG000001564677   OMIM: 1913305   UniProtKB: P149273   

Export aliases for UQCRB gene to outside databases

Previous GC identifers: GC08M096251 GC08M097316 GC08M096911 GC08M097199 GC08M092444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UQCRB Gene:
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one
mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and
participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in
hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this
gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have
been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. (provided by
RefSeq, Dec 2011)

GeneCards Summary for UQCRB Gene:
UQCRB (ubiquinol-cytochrome c reductase binding protein) is a protein-coding gene. Diseases associated with UQCRB include mitochondrial complex iii deficiency, nuclear type 3, and mitochondrial respiratory chain complex iii deficiency, uqcrb-related.

UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927
Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton
pumping

Gene Wiki entry for UQCRB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UQCRB gene promoter:
         Nkx2-5   NF-E2 p45   E47   Pax-3   POU2F1   POU2F1a   Hand1   Pax-4a   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUQCRB promoter sequence
   Search Chromatin IP Primers for UQCRB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UQCRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22

UQCRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UQCRB gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M097311:  view genomic region     (about GC identifiers)

Start:
97,238,148 bp from pter      End:
97,247,862 bp from pter
Size:
9,715 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927 (See protein sequence)
Recommended Name: Cytochrome b-c1 complex subunit 7  
Size: 111 amino acids; 13530 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Caution: Was originally thought to be the ubiquinone-binding protein (QP-C)
Secondary accessions: E5RJU0 Q6FGD1
Alternative splicing: 2 isoforms:  P14927-1   P14927-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UQCRB: NX_P14927

Explore proteomics data for UQCRB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys29
  • Modification sites at PhosphoSitePlus

  • See UQCRB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186904.1  NP_001241681.1  NP_006285.1  

    ENSEMBL proteins: 
     ENSP00000287022   ENSP00000430672   ENSP00000427862   ENSP00000429787   ENSP00000430494  
     ENSP00000430560  
    Reactome Protein details: P14927

    UQCRB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UQCRB
    OriGene Protein Over-expression Lysate for UQCRB
    OriGene MassSpec for UQCRB
    OriGene Custom Protein Services for UQCRB
    GenScript Custom Purified and Recombinant Proteins Services for UQCRB
    Novus Biologicals UQCRB Proteins
    Novus Biologicals UQCRB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UQCRB

     
    Search eBioscience for Proteins for UQCRB 

     
    antibodies-online proteins for UQCRB (13 products) 

     
    antibodies-online peptides for UQCRB

    UQCRB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UQCRB
    Novus Biologicals UQCRB Antibody
    Abcam antibodies for UQCRB
    Cloud-Clone Corp. Antibodies for UQCRB
    Search ThermoFisher Antibodies for UQCRB
    antibodies-online antibodies for UQCRB (21 products) 

    UQCRB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UQCRB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UQCRB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UQCRB
    Cloud-Clone Corp. CLIAs for UQCRB
    Search eBioscience for ELISAs for UQCRB 
    antibodies-online kits for UQCRB (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    comIII: Mitochondrial respiratory chain complex / Complex III

    1 InterPro protein domain:
     IPR003197 QCR7

    Graphical View of Domain Structure for InterPro Entry P14927

    ProtoNet protein and cluster: P14927

    1 Blocks protein domain: IPB003197 Cytochrome bd ubiquinol oxidase

    UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927
    Similarity: Belongs to the UQCRB/QCR7 family


    Find genes that share domains with UQCRB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QCR7_HUMAN, P14927
    Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
    complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton
    pumping

         Genatlas biochemistry entry for UQCRB:
    ubiquinol binding protein,13kDa,component of cytochrome bc1,complex III of mitochondrial respiratory
    chain,oxidative phosphorylation (OXPHOS)

    Phenotypes:
         1 MGI phenotypic allele for Uqcrb (no phenotypes)

    Find genes that share phenotypes with UQCRB           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UQCRB

    miRNA
    Products:
        
    miRTarBase miRNAs that target UQCRB:
    hsa-mir-423-3p (MIRT042467)

    Block miRNA regulation of human, mouse, rat UQCRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UQCRB (see all 62):
    hsa-miR-4317 hsa-miR-548j hsa-miR-4307 hsa-miR-607 hsa-miR-3616-5p hsa-miR-199a-3p hsa-miR-548k hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidUQCRB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UQCRB
    Predesigned siRNA for gene silencing in human, mouse, rat UQCRB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UQCRB

    Clone
    Products:
         
    OriGene clones in human, mouse for UQCRB (see all 6)
    OriGene ORF clones in mouse, rat for UQCRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UQCRB (NM_001199975)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UQCRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UQCRB
    Browse ESI BIO Cell Lines and PureStem Progenitors for UQCRB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    QCR7_HUMAN, P14927: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005746mitochondrial respiratory chain TAS3056408
    GO:0005750mitochondrial respiratory chain complex III IEA--

    Find genes that share ontologies with UQCRB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UQCRB About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction


    Find genes that share SuperPaths with UQCRB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for UQCRB
        Electron Transport Chain

    1 Reactome Pathway for UQCRB
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for UQCRB) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UQCRB
    Interactions:

        Search GeneGlobe Interaction Network for UQCRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UQCRB (P149272, 3 ENSP000002870224) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA4P433582, 3, ENSP000002763444MINT-66319 I2D: score=5 STRING: ENSP00000276344
    MAGEA1P433552, 3, ENSP000003490854MINT-67618 I2D: score=5 STRING: ENSP00000349085
    UQCRC1P319303, ENSP000002034074I2D: score=1 STRING: ENSP00000203407
    CYC1P085743, ENSP000003171594I2D: score=2 STRING: ENSP00000317159
    JUNP054123I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006119oxidative phosphorylation TAS3056408
    GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c IEA--
    GO:0009060aerobic respiration TAS3056408
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--

    Find genes that share ontologies with UQCRB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UQCRB (QCR7)

    3 HMDB Compounds for UQCRB    About this table
    CompoundSynonyms CAS #PubMed Ids
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    9 DrugBank Compounds for UQCRB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    UBIQUINONE-2-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UQCRB gene (3 alternative transcripts): 
    NM_001199975.2  NM_001254752.1  NM_006294.4  

    Unigene Cluster for UQCRB:

    Ubiquinol-cytochrome c reductase binding protein
    Hs.131255  [show with all ESTs]
    Unigene Representative Sequence: NR_045639
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287022(uc011lgt.2 uc010mbc.3 uc022ayx.1 uc003yhq.4)
    ENST00000517603 ENST00000521036 ENST00000518876 ENST00000517523 ENST00000518406
    ENST00000521948 ENST00000523920 ENST00000519322
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UQCRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UQCRB (see all 62):
    hsa-miR-4317 hsa-miR-548j hsa-miR-4307 hsa-miR-607 hsa-miR-3616-5p hsa-miR-199a-3p hsa-miR-548k hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidUQCRB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UQCRB
    Predesigned siRNA for gene silencing in human, mouse, rat UQCRB
    Clone
    Products:
         
    OriGene clones in human, mouse for UQCRB (see all 6)
    OriGene ORF clones in mouse, rat for UQCRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UQCRB (NM_001199975)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UQCRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UQCRB
    OriGene qSTAR qPCR primer pairs in human, mouse for UQCRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UQCRB
      QuantiTect SYBR Green Assays in human, mouse, rat UQCRB
      QuantiFast Probe-based Assays in human, mouse, rat UQCRB

    Additional mRNA sequence: 

    AK307085.1 AK311756.1 BC005230.1 CR542176.1 CR542196.1 M22348.1 M26700.1 NR_045639.1 
    X13585.1 

    21 DOTS entries:

    DT.99983932  DT.101962895  DT.102832785  DT.40284882  DT.75138979  DT.95269282  DT.319597  DT.95269300 
    DT.91754750  DT.91754740  DT.319596  DT.95326572  DT.305302  DT.95269298  DT.121476589  DT.121476609 
    DT.91754747  DT.100037981  DT.100825309  DT.95329379  DT.97859458 

    Selected AceView cDNA sequences (see all 459):

    BX089713 AI752959 BQ213728 AA845970 AA934536 AI884979 F28009 BG574554 
    F31806 BE644783 F31384 CB122949 F29893 AA325055 AA933765 BF971347 
    F31096 F28993 AI800324 F26165 AA369038 BU956567 F24793 BM668206 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UQCRB    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                          -     -               
    SP2:                          -                     
    SP3:                          -                     
    SP4:                                                


    ECgene alternative splicing isoforms for UQCRB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UQCRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTGAAGT
    UQCRB Expression
    About this image


    UQCRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    UQCRB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UQCRB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131255
        Custom PCR Arrays for UQCRB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UQCRB
    OriGene qSTAR qPCR primer pairs in human, mouse for UQCRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UQCRB
    QuantiTect SYBR Green Assays in human, mouse, rat UQCRB
    QuantiFast Probe-based Assays in human, mouse, rat UQCRB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UQCRB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uqcrb1 , 5 ubiquinol-cytochrome c reductase binding protein1, 5 88.29(n)1
    87.39(a)1
      13 (34.54 cM)5
    675301  NM_026219.11  NP_080495.11 
     669006175 
    chicken
    (Gallus gallus)
    Aves UQCRB1 ubiquinol-cytochrome c reductase binding protein 73.87(n)
    75.68(a)
      420236  XM_418347.4  XP_418347.4 
    lizard
    (Anolis carolinensis)
    Reptilia UQCRB6
    ubiquinol-cytochrome c reductase binding protein
    59(a)
    1 ↔ 1
    4(19874254-19878976)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241792 Xenopus laevis transcribed sequence with moderate similarity more 78.41(n)    BI314667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.38872 Transcribed sequence with moderate similarity to protein more 74.77(n)    CF998987.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG178561 CG17856 60.87(n)
    65.22(a)
      43369  NM_143357.3  NP_651614.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes QCR7(YDR529C)4 Subunit 7 of the ubiquinol cytochrome-c reductase complex, more   --   4(1496548-1496165) 852142  NP_010818.1 


    ENSEMBL Gene Tree for UQCRB (if available)
    TreeFam Gene Tree for UQCRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UQCRB gene

    Find genes that share paralogs with UQCRB           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for UQCRB
    PGOHUM00000256868 PGOHUM00000235128 PGOHUM00000235823 PGOHUM00000241342


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UQCRB (see all 254)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732699651,2
    C,F--97244924(+) CAGGCG/ATGGTG 4 -- int11Minor allele frequency- A:0.50WA 2
    rs132608651,2
    C,F,H--97395075(+) TGGGCA/TTTATA 4 -- ds500115Minor allele frequency- T:0.36NS EA NA WA CSA 790
    rs1823835151,2
    --97395127(+) ACATAC/TGAACA 4 -- ds50010--------
    rs1864846031,2
    --97395129(+) ATACGA/GACAGT 4 -- ds50010--------
    rs132616901,2
    C,F,A--97395264(+) ATTTTC/ATAGCT 4 -- ds500112Minor allele frequency- A:0.37NA WA CSA EA 511
    rs1444609701,2
    --97395324(+) ATCAGA/TGTTTC 4 -- ds50010--------
    rs132617471,2
    C,F,A,H--97395372(+) AGAGAA/GAAATT 4 -- ds500124Minor allele frequency- G:0.36NS EA NA WA CSA 2483
    rs1175809151,2
    C,F--97395396(+) TTTGTA/GAAACA 4 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1909204091,2
    --97395421(+) TTTGGC/TTTGGC 4 -- ds50010--------
    rs781314371,2
    C--97395721(+) AACCAC/ACGTAT 4 -- ut31 nc-transcript-variant3Minor allele frequency- A:0.16WA EA 240

    HapMap Linkage Disequilibrium report for UQCRB (97238148 - 97247862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UQCRB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6318CNV Insertion18451855

    Human Gene Mutation Database (HGMD): UQCRB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UQCRB
    DNA2.0 Custom Variant and Variant Library Synthesis for UQCRB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 191330   
    OMIM disorders: 615158  
    UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927
  • Mitochondrial complex III deficiency, nuclear 3 (MC3DN3) [MIM:615158]: A disorder of the mitochondrial
    respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical
    features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver
    dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 5 diseases for UQCRB:    
    About MalaCards
    mitochondrial complex iii deficiency, nuclear type 3    mitochondrial respiratory chain complex iii deficiency, uqcrb-related    mitochondrial complex iii deficiency    mitochondrial complex iii deficiency, nuclear type 6
    hypoxia


    Find genes that share disorders with UQCRB           About GenesLikeMe

    Genetic Association Database (GAD): UQCRB
    Human Genome Epidemiology (HuGE) Navigator: UQCRB (2 documents)

    Export disorders for UQCRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UQCRB gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with UQCRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain. (PubMed id 2543413)1, 2, 3 Suzuki H.... Ozawa T. (Biochem. Biophys. Res. Commun. 1989)
    2. Cloning and sequencing of a cDNA for human mitochondrial ubiquinone- binding protein of complex III. (PubMed id 3056408)1, 2, 3 Suzuki H.... Ozawa T. (Biochem. Biophys. Res. Commun. 1988)
    3. A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis. (PubMed id 12709789)1, 2, 9 Haut S.... Slama A. (Hum. Genet. 2003)
    4. Chromosomal assignment of the gene for the ubiquinone-binding protein of human mitochondrial cytochrome bc1 complex. (PubMed id 2167087)1, 3, 9 Hosokawa Y....Ozawa T. (Biochem. Int. 1990)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Common protein-binding sites in the 5'-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein. (PubMed id 2159470)1, 2 Suzuki H.... Ozawa T. (J. Biol. Chem. 1990)
    9. Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells. (PubMed id 23708980)1 Jung H.J....Kwon H.J. (J. Mol. Med. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7381 HGNC: 12582 AceView: UQCRB Ensembl:ENSG00000156467 euGenes: HUgn7381
    ECgene: UQCRB Kegg: 7381 H-InvDB: UQCRB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UQCRB Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=UQCRB[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UQCRB gene:
    Search GeneIP for patents involving UQCRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UQCRB  
     OriGene qPCR primer pairs and template standards for UQCRB   OriGene Protein Over-expression Lysate for UQCRB  
     OriGene MassSpec for UQCRB   OriGene clones in human, mouse for UQCRB  
     OriGene qSTAR qPCR primer pairs in human, mouse for UQCRB   OriGene Purified Protein for UQCRB  
     OriGene ORF clones in mouse, rat for UQCRB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UQCRB   OriGene Custom Protein Services for UQCRB  

     
     
     Block miRNA regulation of human, mouse, rat UQCRB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UQCRB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UQCRB Predesigned siRNA for gene silencing in human, mouse, rat UQCRB
     QuantiFast Probe-based Assays in human, mouse, rat UQCRB QuantiTect SYBR Green Assays in human, mouse, rat UQCRB
     Custom PCR Arrays for UQCRB Search Chromatin IP Primers for UQCRB
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UQCRB  Search GeneGlobe Interaction Network for UQCRB
     Regulatory tfbs in UQCRB promoter
     GenScript Custom Purified and Recombinant Proteins Services for UQCRB GenScript cDNA clones with any tag delivered in your preferred vector for UQCRB
     GenScript Custom Assay Services for UQCRB GenScript Custom overexpressing Cell Line Services for UQCRB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UQCRB (QCR7)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UQCRB antibodies
     UQCRB proteins
     UQCRB lysates
     Antibodies for UQCRB
     See all of Abcam's Antibodies, Kits and Proteins for UQCRB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UQCRB
     Antibodies for UQCRB
     ELISAs for UQCRB
     CLIAs for UQCRB



     Browse ESI BIO Cell Lines and PureStem Progenitors for UQCRB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCRB
     SwitchGear 3'UTR luciferase reporter plasmids for UQCRB
     SwitchGear Promoter luciferase reporter plasmids for UQCRB
     Search ThermoFisher Antibodies for UQCRB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCRB
     Browse compounds at ApexBio
     Search Addgene for plasmids for UQCRB
      Search eBioscience for proteins for UQCRB
      Search eBioscience for elisas for UQCRB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for UQCRB
     antibodies-online antibodies for UQCRB (21 products)
     antibodies-online kits for UQCRB (6 products)
     antibodies-online peptides for UQCRB
     antibodies-online proteins for UQCRB (13 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UQCRB gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4