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Aliases for UQCRB Gene

Aliases for UQCRB Gene

  • Ubiquinol-Cytochrome C Reductase Binding Protein 2 3 5
  • Ubiquinol-Cytochrome C Reductase Complex 14 KDa Protein 3 4
  • Complex III Subunit VII 3 4
  • Complex III Subunit 7 3 4
  • UQBP 3 4
  • QP-C 3 4
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit VI 3
  • Mitochondrial Ubiquinone-Binding Protein 3
  • Cytochrome B-C1 Complex Subunit 7 2
  • Ubiquinol-Cytochrome C Reductase 2
  • Complex III Subunit VI 2
  • MC3DN3 3
  • UQCR6 3
  • QCR7 3
  • UQBC 3
  • UQPC 3
  • QPC 3

External Ids for UQCRB Gene

Previous HGNC Symbols for UQCRB Gene

  • UQBP

Previous GeneCards Identifiers for UQCRB Gene

  • GC08M096251
  • GC08M097316
  • GC08M096911
  • GC08M097199
  • GC08M097311
  • GC08M092444

Summaries for UQCRB Gene

Entrez Gene Summary for UQCRB Gene

  • This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]

GeneCards Summary for UQCRB Gene

UQCRB (Ubiquinol-Cytochrome C Reductase Binding Protein) is a Protein Coding gene. Diseases associated with UQCRB include Mitochondrial Complex Iii Deficiency, Nuclear Type 3 and Mitochondrial Complex Iii Deficiency, Nuclear Type 1. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism.

UniProtKB/Swiss-Prot for UQCRB Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.

Gene Wiki entry for UQCRB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCRB Gene

Genomics for UQCRB Gene

Regulatory Elements for UQCRB Gene

Enhancers for UQCRB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UQCRB on UCSC Golden Path with GeneCards custom track

Promoters for UQCRB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UQCRB on UCSC Golden Path with GeneCards custom track

Genomic Location for UQCRB Gene

Chromosome:
8
Start:
96,225,920 bp from pter
End:
96,235,634 bp from pter
Size:
9,715 bases
Orientation:
Minus strand

Genomic View for UQCRB Gene

Genes around UQCRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCRB Gene

Proteins for UQCRB Gene

  • Protein details for UQCRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14927-QCR7_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 7
    Protein Accession:
    P14927
    Secondary Accessions:
    • E5RJU0
    • Q6FGD1

    Protein attributes for UQCRB Gene

    Size:
    111 amino acids
    Molecular mass:
    13530 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Alternative splice isoforms for UQCRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UQCRB Gene

Proteomics data for UQCRB Gene at MOPED

Post-translational modifications for UQCRB Gene

  • Ubiquitination at Lys 12 and Lys 29
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UQCRB Gene

Domains & Families for UQCRB Gene

Protein Domains for UQCRB Gene

Graphical View of Domain Structure for InterPro Entry

P14927

UniProtKB/Swiss-Prot:

QCR7_HUMAN :
  • Belongs to the UQCRB/QCR7 family.
Family:
  • Belongs to the UQCRB/QCR7 family.
genes like me logo Genes that share domains with UQCRB: view

Function for UQCRB Gene

Molecular function for UQCRB Gene

GENATLAS Biochemistry:
ubiquinol binding protein,13kDa,component of cytochrome bc1,complex III of mitochondrial respiratory chain,oxidative phosphorylation (OXPHOS)
UniProtKB/Swiss-Prot Function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.
genes like me logo Genes that share phenotypes with UQCRB: view

Human Phenotype Ontology for UQCRB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for UQCRB Gene

MGI Knock Outs for UQCRB:

Animal Model Products

miRNA for UQCRB Gene

miRTarBase miRNAs that target UQCRB

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for UQCRB Gene

Localization for UQCRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCRB Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCRB Gene COMPARTMENTS Subcellular localization image for UQCRB gene
Compartment Confidence
mitochondrion 5

No data available for Gene Ontology (GO) - Cellular Components for UQCRB Gene

Pathways & Interactions for UQCRB Gene

genes like me logo Genes that share pathways with UQCRB: view

Gene Ontology (GO) - Biological Process for UQCRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034551 mitochondrial respiratory chain complex III assembly IBA --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process TAS 3056408
genes like me logo Genes that share ontologies with UQCRB: view

No data available for SIGNOR curated interactions for UQCRB Gene

Drugs & Compounds for UQCRB Gene

(10) Drugs for UQCRB Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE Experimental Pharma Target 0

(1) Additional Compounds for UQCRB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
genes like me logo Genes that share compounds with UQCRB: view

Transcripts for UQCRB Gene

Unigene Clusters for UQCRB Gene

Ubiquinol-cytochrome c reductase binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCRB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for UQCRB Gene

GeneLoc Exon Structure for
UQCRB
ECgene alternative splicing isoforms for
UQCRB

Expression for UQCRB Gene

mRNA expression in normal human tissues for UQCRB Gene

mRNA differential expression in normal tissues according to GTEx for UQCRB Gene

This gene is overexpressed in Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for UQCRB Gene

This gene is overexpressed in Brain (13.8) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCRB Gene



SOURCE GeneReport for Unigene cluster for UQCRB Gene Hs.131255

genes like me logo Genes that share expression patterns with UQCRB: view

Protein tissue co-expression partners for UQCRB Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UQCRB Gene

Orthologs for UQCRB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UQCRB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UQCRB 35
  • 89.19 (n)
  • 85.59 (a)
UQCRB 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC477944 35
  • 87.88 (n)
  • 89.09 (a)
UQCRB 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uqcrb 35
  • 88.29 (n)
  • 87.39 (a)
Uqcrb 16
Uqcrb 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UQCRB 35
  • 99.1 (n)
  • 100 (a)
UQCRB 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UQCRB 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UQCRB 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves UQCRB 35
  • 73.87 (n)
  • 75.68 (a)
lizard
(Anolis carolinensis)
Reptilia UQCRB 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732809 35
  • 72.37 (n)
  • 72.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24179 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3887 35
uqcrb 35
  • 68.77 (n)
  • 72.07 (a)
uqcrb 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12392 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012188 35
  • 59.93 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17856 35
  • 60.87 (n)
  • 65.22 (a)
CG17856 36
  • 44 (a)
OneToMany
CG3560 36
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes QCR7 36
  • 28 (a)
OneToOne
QCR7 38
Species with no ortholog for UQCRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UQCRB Gene

ENSEMBL:
Gene Tree for UQCRB (if available)
TreeFam:
Gene Tree for UQCRB (if available)

Paralogs for UQCRB Gene

Pseudogenes.org Pseudogenes for UQCRB Gene

genes like me logo Genes that share paralogs with UQCRB: view

No data available for Paralogs for UQCRB Gene

Variants for UQCRB Gene

Sequence variations from dbSNP and Humsavar for UQCRB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs35895613 - 96,233,158(+) TACCC(A/G)GTTTA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2292835 -- 96,231,492(+) GCAGA(A/G)TGCAG intron-variant, nc-transcript-variant, reference, synonymous-codon
rs2292836 -- 96,227,385(+) TGTAC(A/C)CTAAG nc-transcript-variant, utr-variant-3-prime
rs7832969 -- 96,230,537(+) CTAAC(A/G)TCTTT nc-transcript-variant, utr-variant-3-prime
rs7832982 -- 96,230,555(+) CTAGT(A/C)TACAT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UQCRB Gene

Variant ID Type Subtype PubMed ID
nsv6318 CNV Insertion 18451855

Variation tolerance for UQCRB Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UQCRB Gene

Human Gene Mutation Database (HGMD)
UQCRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCRB Gene

Disorders for UQCRB Gene

MalaCards: The human disease database

(4) MalaCards diseases for UQCRB Gene - From: OMIM, ClinVar, GeneTests, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial complex iii deficiency, nuclear type 3
  • mitochondrial complex iii deficiency nuclear type 3
mitochondrial complex iii deficiency, nuclear type 1
  • mitochondrial complex iii deficiency nuclear type 1
mitochondrial complex iii deficiency
  • complex 3 mitochondrial respiratory chain deficiency
mitochondrial respiratory chain complex iii deficiency, uqcrb-related
  • mitochondrial complex iii deficiency, uqcrb-related
- elite association - COSMIC cancer census association via MalaCards
Search UQCRB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

QCR7_HUMAN
  • Mitochondrial complex III deficiency, nuclear 3 (MC3DN3) [MIM:615158]: A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. {ECO:0000269 PubMed:12709789}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for UQCRB

Genetic Association Database (GAD)
UQCRB
Human Genome Epidemiology (HuGE) Navigator
UQCRB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UQCRB
genes like me logo Genes that share disorders with UQCRB: view

No data available for Genatlas for UQCRB Gene

Publications for UQCRB Gene

  1. Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain. (PMID: 2543413) Suzuki H. … Ozawa T. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 67
  2. Chromosomal assignment of the gene for the ubiquinone-binding protein of human mitochondrial cytochrome bc1 complex. (PMID: 2167087) Hosokawa Y. … Ozawa T. (Biochem. Int. 1990) 2 3 23
  3. A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis. (PMID: 12709789) Haut S. … Slama A. (Hum. Genet. 2003) 3 23
  4. Cloning and sequencing of a cDNA for human mitochondrial ubiquinone- binding protein of complex III. (PMID: 3056408) Suzuki H. … Ozawa T. (Biochem. Biophys. Res. Commun. 1988) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for UQCRB Gene

Sources for UQCRB Gene

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