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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UQCRB Gene

protein-coding   GIFtS: 60
GCID: GC08M097311

ubiquinol-cytochrome c reductase binding protein


(Previous symbol: UQBP)
 Explore 10 diseases affiliated with
UQCRB via our new
 Human Malady Compendium 
Biological research products
for UQCRB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ubiquinol-Cytochrome C Reductase Binding Protein1 2     Ubiquinol-Cytochrome C Reductase Complex 14 KDa Protein2 3
UQBP1 2 3 5     QPC2 5
QP-C1 2 3     UQBC2
QCR71 2     UQPC2
UQCR61 2     Cytochrome B-C1 Complex Subunit 72
Complex III Subunit 72 3     Mitochondrial Ubiquinone-Binding Protein2
Complex III Subunit VII2 3     Ubiquinol-Cytochrome C Reductase, Complex III Subunit VI2

External Ids:    HGNC: 125821   Entrez Gene: 73812   Ensembl: ENSG000001564677   OMIM: 1913305   UniProtKB: P149273   

Export aliases for UQCRB gene to outside databases

Previous GC identifers: GC08M096251 GC08M097316 GC08M096911 GC08M097199 GC08M092444


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UQCRB:
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one
mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and
participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in
hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene
are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found
for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927
Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex),
which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping

Gene Wiki entry for UQCRB


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UQCRB gene promoter:
         Nkx2-5   NF-E2 p45   E47   Pax-3   POU2F1   POU2F1a   Hand1   Pax-4a   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUQCRB promoter sequence
   Search SABiosciences Chromatin IP Primers for UQCRB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UQCRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22

UQCRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UQCRB gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M097311:  view genomic region     (about GC identifiers)

Start:
97,238,148 bp from pter      End:
97,247,862 bp from pter
Size:
9,715 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927 (See protein sequence)
Recommended Name: Cytochrome b-c1 complex subunit 7  
Size: 111 amino acids; 13530 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1),
2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8,
UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Subcellular location: Mitochondrion inner membrane
Caution: Was originally thought to be the ubiquinone-binding protein (QP-C)
Secondary accessions: E5RJU0 Q6FGD1
Alternative splicing: 2 isoforms:  P14927-1   P14927-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UQCRB: NX_P14927

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14927

  • UQCRB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186904.1  NP_001241681.1  NP_006285.1  

    ENSEMBL proteins: 
     ENSP00000287022   ENSP00000430672   ENSP00000427862   ENSP00000429787   ENSP00000430494  
     ENSP00000430560  
    Reactome Protein details: P14927
    Human Recombinant Protein Products: 
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    Uscn Proteins for UQCRB

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005746mitochondrial respiratory chain TAS3056408


    UQCRB for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UQCRB for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003197 QCR7

    Graphical View of Domain Structure for InterPro Entry P14927

    ProtoNet protein and cluster: P14927

    1 Blocks protein family: IPB003197 Cytochrome bd ubiquinol oxidase

    UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927
    Similarity: Belongs to the UQCRB/QCR7 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927
    Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex),
    which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping

         Genatlas biochemistry entry for UQCRB:
    ubiquinol binding protein,13kDa,component of cytochrome bc1,complex III of mitochondrial respiratory chain,oxidative
    phosphorylation (OXPHOS)

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008121ubiquinol-cytochrome-c reductase activity IEA--


    UQCRB for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
    Oxidative phosphorylation0.63
    Respiratory electron transport0.81
    Parkinson's disease0.61
    Electron Transport Chain0.76
    Alzheimer's disease0.43
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Huntington's disease0.40
    2Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    3Cardiac muscle contraction
    Cardiac muscle contraction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for UQCRB 
        Electron Transport Chain

    4        Reactome Pathways for UQCRB
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for UQCRB) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Alzheimer's disease
    Parkinson's disease


    UQCRB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UQCRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for UQCRB (P149272, 3 ENSP000002870224) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA4P433582, 3, ENSP000002763444MINT-66319 I2D: score=5 STRING: ENSP00000276344
    MAGEA1P433552, 3, ENSP000003490854MINT-67618 I2D: score=5 STRING: ENSP00000349085
    UQCRC1P319303, ENSP000002034074I2D: score=1 STRING: ENSP00000203407
    CYC1P085743, ENSP000003171594I2D: score=2 STRING: ENSP00000317159
    JUNP054123I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006119oxidative phosphorylation TAS3056408
    GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c IEA--
    GO:0009060aerobic respiration TAS3056408
    GO:0022904respiratory electron transport chain TAS--
    GO:0044281small molecule metabolic process TAS--


    UQCRB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UQCRB

    3 HMDB Compounds for UQCRB    About this table
    CompoundSynonyms CAS #PubMed Ids
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    9 DrugBank Compounds for UQCRB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    UBIQUINONE-2-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about UQCRB / QCR7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UQCRB gene (3 alternative transcripts): 
    NM_001199975.2  NM_001254752.1  NM_006294.4  

    Unigene Cluster for UQCRB:

    Ubiquinol-cytochrome c reductase binding protein
    Hs.131255  [show with all ESTs]
    Unigene Representative Sequence: NR_045639
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287022(uc011lgt.2 uc010mbc.3 uc022ayx.1 uc003yhq.4)
    ENST00000517603 ENST00000521036 ENST00000518876 ENST00000517523 ENST00000518406
    ENST00000521948 ENST00000523920 ENST00000519322

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    hsa-miR-4317 hsa-miR-548j hsa-miR-4307 hsa-miR-607 hsa-miR-3616-5p hsa-miR-199a-3p hsa-miR-548k hsa-miR-25
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    Additional cDNA sequence: 

    AK307085.1 AK311756.1 BC005230.1 CR542176.1 CR542196.1 M22348.1 M26700.1 NR_045639.1 
    X13585.1 

    21 DOTS entries:

    DT.99983932  DT.101962895  DT.102832785  DT.40284882  DT.75138979  DT.95269282  DT.319597  DT.95269300 
    DT.91754750  DT.91754740  DT.319596  DT.95326572  DT.305302  DT.95269298  DT.121476589  DT.121476609 
    DT.91754747  DT.100037981  DT.100825309  DT.95329379  DT.97859458 

    24/459 AceView cDNA sequences (see all 459):

    BM795785 BI764837 AI800324 AA314045 BE833948 F30219 BM668206 BX089713 
    F25283 F26165 CD676645 AA363191 CD678966 AA622677 AA369038 AA325055 
    AW020084 F26112 AI884979 F20454 AJ713825 AA664284 CD679095 AV708140 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UQCRB    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                          -     -               
    SP2:                          -                     
    SP3:                          -                     
    SP4:                                                


    ECgene alternative splicing isoforms for UQCRB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UQCRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTTGAAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See UQCRB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UQCRB

    SOURCE GeneReport for Unigene cluster: Hs.131255
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UQCRB gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uqcrb1 , 5 ubiquinol-cytochrome c reductase binding protein1, 5 88.29(n)1
    87.39(a)1
      13 (34.54 cM)5
    675301  NM_026219.11  NP_080495.11 
     669006175 
    chicken
    (Gallus gallus)
    Aves UQCRB1 ubiquinol-cytochrome c reductase binding protein 73.87(n)
    75.68(a)
      420236  XM_418347.3  XP_418347.3 
    lizard
    (Anolis carolinensis)
    Reptilia UQCRB6
    --
    73(a)
    1 ↔ 1
    4(19874254-19878976)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241792 Xenopus laevis transcribed sequence with moderate similarity more 78.41(n)    BI314667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.38872 Transcribed sequence with moderate similarity to protein more 74.77(n)    CF998987.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG178561 CG17856 60.87(n)
    65.22(a)
      43369  NM_143357.2  NP_651614.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T02H6.116
    Protein T02H6.11
    29(a)
    1 ↔ 1
    II(700481-701144)


    ENSEMBL Gene Tree for UQCRB (if available)
    TreeFam Gene Tree for UQCRB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UQCRB gene

    UQCRB for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for UQCRB
    PGOHUM00000256868 PGOHUM00000235128 PGOHUM00000235823 PGOHUM00000241342


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/207 NCBI SNPs in UQCRB are shown (see all 207    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732699611,2
    C,--92445510(+) GCTTTG/AGCCCA 4 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.04WA 120
    rs594575631,2
    C,F,--92446649(+) CAATGT/CAGATT 4 -- ut31 nc-transcript-variant4Minor allele frequency- C:0.33WA CSA 123
    rs169185651,2
    C,F,--92447086(+) TCTATT/GTGTTC 4 -- ut31 nc-transcript-variant7Minor allele frequency- G:0.05NA WA 266
    rs286435491,2
    --92447941(+) TGCAAC/TCTCCA 4 -- ut31 nc-transcript-variant0--------
    rs285210941,2
    C,F,--92448016(+) CATCAT/CGCCTA 4 -- nc-transcript-variantut313Minor allele frequency- C:0.40NA CSA 5
    rs577230451,2
    C,--92448108(+) CGCCCG/ACCTCG 4 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.50WA 2
    rs78329691,2
    A,--92448321(+) CTAACA/GTCTTT 4 -- ut31 nc-transcript-variant0--------
    rs78329821,2
    A--92448339(+) CTAGTA/CTACAT 4 -- ut31 nc-transcript-variantese30--------
    rs78331141,2
    C,A--92448352(+) TAGCAC/TAGGAG 4 -- ut31 nc-transcript-variantese30--------
    rs78333801,2
    C,A,--92448361(+) AGTATA/GTATAT 4 -- ut31 nc-transcript-variantese30--------

    HapMap Linkage Disequilibrium report for UQCRB (97238148 - 97247862 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for UQCRB
         2 CNVs: 82698 95582
    Human Gene Mutation Database (HGMD): UQCRB

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UQCRB
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UQCRB for disorders           About GeneDecksing

    OMIM gene information: 191330   
    OMIM disorders: 124000  
    UniProtKB/Swiss-Prot: QCR7_HUMAN, P14927
  • Defects in UQCRB are a cause of mitochondrial complex III deficiency (MT-C3D) [MIM:124000]. A disorder of the
  • mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected.
    Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive,
    liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance

    10 diseases for UQCRB:    About MalaCards
    mitochondrial complex iii deficiency    lactic acidosis    hypoxia    huntington's disease
    parkinson's disease    pancreatic cancer    pancreatitis    ataxia
    thyroiditis    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: UQCRB (2 documents)

    Export disorders for UQCRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UQCRB gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with UQCRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain. (PubMed id 2543413)1, 2, 3 Suzuki H.... Ozawa T. (1989)
    2. Cloning and sequencing of a cDNA for human mitochondrial ubiquinone- binding protein of complex III. (PubMed id 3056408)1, 2, 3 Suzuki H.... Ozawa T. (1988)
    3. A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis. (PubMed id 12709789)1, 2, 9 Haut S.... Slama A. (2003)
    4. Chromosomal assignment of the gene for the ubiquinone-binding protein of human mitochondrial cytochrome bc1 complex. (PubMed id 2167087)1, 3, 9 Hosokawa Y....Ozawa T. (1990)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Common protein-binding sites in the 5'-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein. (PubMed id 2159470)1, 2 Suzuki H.... Ozawa T. (1990)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Polymorphisms in the mitochondrial oxidative phosphory lation chain genes as prognostic markers for colorectal cancer. (PubMed id 22545919)1 Lascorz J....Schafmayer C. (2012)
    9. Responses of muscle mass, strength and gene transcrip ts to long-term heat stress in healthy human subjects. (PubMed id 20803152)1 Goto K....Yoshioka T. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7381 HGNC: 12582 AceView: UQCRB Ensembl:ENSG00000156467 euGenes: HUgn7381
    ECgene: UQCRB Kegg: 7381 H-InvDB: UQCRB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UQCRB Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/UQCRB

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UQCRB gene:
    Search GeneIP for patents involving UQCRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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