Aliases for UQCRB Gene
External Ids for UQCRB Gene
Previous HGNC Symbols for UQCRB Gene
Previous GeneCards Identifiers for UQCRB Gene
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
GeneCards Summary for UQCRB Gene
UQCRB (Ubiquinol-Cytochrome C Reductase Binding Protein) is a Protein Coding gene. Diseases associated with UQCRB include Mitochondrial Complex Iii Deficiency, Nuclear Type 3 and Mitochondrial Complex Iii Deficiency, Nuclear Type 1. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cardiac muscle contraction.
UniProtKB/Swiss-Prot for UQCRB Gene
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.