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Aliases for UQCR11 Gene

Aliases for UQCR11 Gene

  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit XI 2 3
  • Complex III Subunit 10 2 3 4
  • UQCR 3 4 6
  • Ubiquinol-Cytochrome C Reductase Complex 6.4 KDa Protein 3 4
  • Ubiquinol-Cytochrome C Reductase, 6.4kDa Subunit 2 3
  • Complex III Subunit XI 3 4
  • Ubiquinol Cytochrome C Reductase, 6.4kDa Subunit 3
  • Cytochrome B-C1 Complex Subunit 10 3
  • 0710008D09Rik 3
  • QCR10 3

External Ids for UQCR11 Gene

Previous Symbols for UQCR11 Gene

  • UQCR

Summaries for UQCR11 Gene

Entrez Gene Summary for UQCR11 Gene

  • This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]

GeneCards Summary for UQCR11 Gene

UQCR11 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit XI) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot for UQCR11 Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain

  • This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCR11 Gene

Genomics for UQCR11 Gene

Genomic Location for UQCR11 Gene

Start:
1,597,155 bp from pter
End:
1,605,490 bp from pter
Size:
8,336 bases
Orientation:
Minus strand

Genomic View for UQCR11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UQCR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCR11 Gene

No data available for Regulatory Elements for UQCR11 Gene

Proteins for UQCR11 Gene

  • Protein details for UQCR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14957-QCR10_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 10
    Protein Accession:
    O14957
    Secondary Accessions:
    • B2R542
    • D6W5Z4
    • Q9UEA3
    • Q9UPK4

    Protein attributes for UQCR11 Gene

    Size:
    56 amino acids
    Molecular mass:
    6570 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)

neXtProt entry for UQCR11 Gene

Proteomics data for UQCR11 Gene at MOPED

Post-translational modifications for UQCR11 Gene

Other Protein References for UQCR11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UQCR11 Gene

Domains for UQCR11 Gene

Gene Families for UQCR11 Gene

HGNC:
  • comIII :Mitochondrial respiratory chain complex / Complex III

Protein Domains for UQCR11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UQCR11 Gene

Graphical View of Domain Structure for InterPro Entry

O14957

UniProtKB/Swiss-Prot:

QCR10_HUMAN
Family:
  • Belongs to the UQCR11/QCR10 family.:
    • O14957
genes like me logo Genes that share domains with UQCR11: view

Function for UQCR11 Gene

Molecular function for UQCR11 Gene

UniProtKB/Swiss-Prot Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain
UniProtKB/Swiss-Prot Function: This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor

Gene Ontology (GO) - Molecular Function for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008121 ubiquinol-cytochrome-c reductase activity IEA --
GO:0009055 electron carrier activity TAS 9161705
genes like me logo Genes that share ontologies with UQCR11: view

Phenotypes for UQCR11 Gene

GenomeRNAi human phenotypes for UQCR11:
genes like me logo Genes that share phenotypes with UQCR11: view

miRNA for UQCR11 Gene

miRTarBase miRNAs that target UQCR11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UQCR11 Gene

Localization for UQCR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCR11 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCR11 Gene COMPARTMENTS Subcellular localization image for UQCR11 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with UQCR11: view

Pathways for UQCR11 Gene

genes like me logo Genes that share pathways with UQCR11: view

Gene Ontology (GO) - Biological Process for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 9161705
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with UQCR11: view

Compounds for UQCR11 Gene

(4) HMDB Compounds for UQCR11 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6
QH2
  • CoQH2
56275-39-9
Ubiquinone Q1
  • Coenzyme Q
727-81-1
Ubiquinone Q2
  • 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
606-06-4
genes like me logo Genes that share compounds with UQCR11: view

Transcripts for UQCR11 Gene

mRNA/cDNA for UQCR11 Gene

Unigene Clusters for UQCR11 Gene

Ubiquinol-cytochrome c reductase, complex III subunit XI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCR11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for UQCR11 Gene

GeneLoc Exon Structure for
UQCR11
ECgene alternative splicing isoforms for
UQCR11

Expression for UQCR11 Gene

mRNA expression in normal human tissues for UQCR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCR11 Gene

This gene is overexpressed in Liver (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCR11 Gene

SOURCE GeneReport for Unigene cluster for UQCR11 Gene Hs.8372

genes like me logo Genes that share expressions with UQCR11: view

No data available for mRNA Expression by UniProt/SwissProt for UQCR11 Gene

Orthologs for UQCR11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UQCR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
UQCR11 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 68 (a)
ManyToMany
UQCR11 35
  • 83.93 (n)
  • 87.5 (a)
UQCR11 36
  • 88 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia UQCR11 35
  • 83.93 (n)
  • 85.71 (a)
UQCR11 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Uqcr11 35
  • 83.93 (n)
  • 83.93 (a)
Uqcr11 16
Uqcr11 36
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia UQCR11 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Uqcr11 35
  • 82.74 (n)
  • 83.93 (a)
chicken
(Gallus gallus)
Aves UQCR11 36
  • 57 (a)
OneToMany
Species with no ortholog for UQCR11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UQCR11 Gene

ENSEMBL:
Gene Tree for UQCR11 (if available)
TreeFam:
Gene Tree for UQCR11 (if available)

Paralogs for UQCR11 Gene

Pseudogenes.org Pseudogenes for UQCR11 Gene

genes like me logo Genes that share paralogs with UQCR11: view

No data available for Paralogs for UQCR11 Gene

Variants for UQCR11 Gene

Sequence variations from dbSNP and Humsavar for UQCR11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8697 -- 1,598,204(-) GGTGG(C/T)GCTAG utr-variant-3-prime
rs758137 -- 1,605,633(+) GGCGG(G/T)GCTTT upstream-variant-2KB
rs887390 -- 1,600,036(+) GCTCA(C/T)GCTCT intron-variant
rs1044278 -- 1,598,131(-) AACCC(A/C)CAGCT utr-variant-3-prime
rs1062810 -- 1,597,212(-) aaaaa(A/G)aaaaa utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UQCR11 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
dgv3607n71 CNV Loss 21882294
dgv3608n71 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3610n71 CNV Loss 21882294
nsv910540 CNV Loss 21882294
dgv3611n71 CNV Loss 21882294

Relevant External Links for UQCR11 Gene

HapMap Linkage Disequilibrium report
UQCR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCR11 Gene

Disorders for UQCR11 Gene

Relevant External Links for UQCR11

Genetic Association Database (GAD)
UQCR11
Human Genome Epidemiology (HuGE) Navigator
UQCR11
genes like me logo Genes that share disorders with UQCR11: view

No data available for UniProtKB/Swiss-Prot for UQCR11 Gene

Publications for UQCR11 Gene

  1. Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences. (PMID: 9161705) Islam M.M. … Tanaka M. (Biochem. Mol. Biol. Int. 1997) 2 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for UQCR11 Gene

Sources for UQCR11 Gene

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