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Aliases for UQCR11 Gene

Aliases for UQCR11 Gene

  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit XI 2 3 5
  • Complex III Subunit 10 2 3 4
  • Ubiquinol-Cytochrome C Reductase Complex 6.4 KDa Protein 3 4
  • Ubiquinol-Cytochrome C Reductase, 6.4kDa Subunit 2 3
  • Complex III Subunit XI 3 4
  • UQCR 3 4
  • Cytochrome B-C1 Complex Subunit 10 3
  • 0710008D09Rik 3
  • QCR10 3

External Ids for UQCR11 Gene

Previous HGNC Symbols for UQCR11 Gene

  • UQCR

Previous GeneCards Identifiers for UQCR11 Gene

  • GC19M001371

Summaries for UQCR11 Gene

Entrez Gene Summary for UQCR11 Gene

  • This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]

GeneCards Summary for UQCR11 Gene

UQCR11 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit XI) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include electron transfer activity and ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is ENSG00000267059.

UniProtKB/Swiss-Prot for UQCR11 Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.

  • This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

Additional gene information for UQCR11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCR11 Gene

Genomics for UQCR11 Gene

GeneHancer (GH) Regulatory Elements for UQCR11 Gene

Promoters and enhancers for UQCR11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I001603 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 73 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000267059 UQCR11 TCF3 ATP8B3 SF3A2 LOC100288123 DAZAP1 TMEM259 DOT1L PTBP1
GH19I001647 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.8 -45.0 -44966 6.6 CLOCK ZFP64 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D TCF3 SF3A2 LOC100288123 DAZAP1 DOT1L TMEM259 STK11 CIRBP AP3D1 MUM1
GH19I001772 Enhancer 0.9 ENCODE dbSUPER 12.2 -168.1 -168094 1.4 JUN MAX KLF17 HIC1 SCRT2 VEZF1 RCOR1 FOS TCF7L2 SCRT1 ATP8B3 REXO1 UQCR11 TCF3 RNU6-1223P MOB3A LOC101928543 GC19M001748 ONECUT3
GH19I001406 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.3 +192.7 192660 13.5 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D DAZAP1 TCF3 SF3A2 TMEM259 PTBP1 LOC100288123 GRIN3B RPS15 ENSG00000267317 CIRBP
GH19I001608 Enhancer 1 Ensembl ENCODE dbSUPER 0.8 -3.8 -3765 1.7 BCOR KLF17 ZIC2 ZNF121 HIC1 GLIS2 POLR2A GLIS1 NFATC1 ZBTB33 GC19P001610 TCF3 ATP8B3 REXO1 UQCR11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UQCR11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for UQCR11 Gene

Genomic Locations for UQCR11 Gene
chr19:1,597,155-1,605,490
(GRCh38/hg38)
Size:
8,336 bases
Orientation:
Minus strand
chr19:1,597,154-1,605,483
(GRCh37/hg19)

Genomic View for UQCR11 Gene

Genes around UQCR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCR11 Gene

Proteins for UQCR11 Gene

  • Protein details for UQCR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14957-QCR10_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 10
    Protein Accession:
    O14957
    Secondary Accessions:
    • B2R542
    • D6W5Z4
    • Q9UEA3
    • Q9UPK4

    Protein attributes for UQCR11 Gene

    Size:
    56 amino acids
    Molecular mass:
    6570 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Three dimensional structures from OCA and Proteopedia for UQCR11 Gene

neXtProt entry for UQCR11 Gene

Post-translational modifications for UQCR11 Gene

Other Protein References for UQCR11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UQCR11 Gene

Domains & Families for UQCR11 Gene

Protein Domains for UQCR11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UQCR11 Gene

Graphical View of Domain Structure for InterPro Entry

O14957

UniProtKB/Swiss-Prot:

QCR10_HUMAN :
  • Belongs to the UQCR11/QCR10 family.
Family:
  • Belongs to the UQCR11/QCR10 family.
genes like me logo Genes that share domains with UQCR11: view

Function for UQCR11 Gene

Molecular function for UQCR11 Gene

UniProtKB/Swiss-Prot Function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
UniProtKB/Swiss-Prot Function:
This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

Phenotypes From GWAS Catalog for UQCR11 Gene

Gene Ontology (GO) - Molecular Function for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008121 ubiquinol-cytochrome-c reductase activity IEA,IBA --
GO:0009055 electron transfer activity TAS 9161705
genes like me logo Genes that share ontologies with UQCR11: view
genes like me logo Genes that share phenotypes with UQCR11: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCR11 Gene

Localization for UQCR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCR11 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UQCR11 gene
Compartment Confidence
mitochondrion 5
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with UQCR11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UQCR11 Gene

Pathways & Interactions for UQCR11 Gene

genes like me logo Genes that share pathways with UQCR11: view

Gene Ontology (GO) - Biological Process for UQCR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 9161705
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c TAS --
GO:0055114 oxidation-reduction process IEA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with UQCR11: view

No data available for SIGNOR curated interactions for UQCR11 Gene

Drugs & Compounds for UQCR11 Gene

(8) Drugs for UQCR11 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole Experimental Pharma Target 0
FAMOXADONE Experimental Pharma Target 0

(2) Additional Compounds for UQCR11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
genes like me logo Genes that share compounds with UQCR11: view

Transcripts for UQCR11 Gene

Unigene Clusters for UQCR11 Gene

Ubiquinol-cytochrome c reductase, complex III subunit XI:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UQCR11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for UQCR11 Gene

GeneLoc Exon Structure for
UQCR11
ECgene alternative splicing isoforms for
UQCR11

Expression for UQCR11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UQCR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UQCR11 Gene

This gene is overexpressed in Liver (x4.5).

Protein differential expression in normal tissues from HIPED for UQCR11 Gene

This gene is overexpressed in Testis (17.2), Gallbladder (7.1), Liver (6.4), and Lung (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UQCR11 Gene



NURSA nuclear receptor signaling pathways regulating expression of UQCR11 Gene:

UQCR11

SOURCE GeneReport for Unigene cluster for UQCR11 Gene:

Hs.8372

Evidence on tissue expression from TISSUES for UQCR11 Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Muscle(2.8)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with UQCR11: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UQCR11 Gene

Orthologs for UQCR11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UQCR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UQCR11 33
  • 100 (n)
-- 34
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia UQCR11 33 34
  • 83.93 (n)
-- 34
  • 68 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia UQCR11 33 34
  • 83.93 (n)
mouse
(Mus musculus)
Mammalia Uqcr11 33 16 34
  • 83.93 (n)
rat
(Rattus norvegicus)
Mammalia Uqcr11 33
  • 82.74 (n)
oppossum
(Monodelphis domestica)
Mammalia UQCR11 34
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves UQCR11 34
  • 57 (a)
OneToMany
Species where no ortholog for UQCR11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UQCR11 Gene

ENSEMBL:
Gene Tree for UQCR11 (if available)
TreeFam:
Gene Tree for UQCR11 (if available)

Paralogs for UQCR11 Gene

Paralogs for UQCR11 Gene

Pseudogenes.org Pseudogenes for UQCR11 Gene

genes like me logo Genes that share paralogs with UQCR11: view

Variants for UQCR11 Gene

Sequence variations from dbSNP and Humsavar for UQCR11 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000100831 -- 1,604,709(-) G/C intron_variant
rs1000223771 -- 1,599,323(-) C/T intron_variant
rs1000318476 -- 1,606,344(-) A/C upstream_transcript_variant
rs1000438811 -- 1,601,122(-) T/C intron_variant
rs1000439712 -- 1,606,153(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UQCR11 Gene

Variant ID Type Subtype PubMed ID
esv32942 CNV gain+loss 17666407
nsv953942 CNV deletion 24416366

Variation tolerance for UQCR11 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UQCR11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UQCR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCR11 Gene

Disorders for UQCR11 Gene

Additional Disease Information for UQCR11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UQCR11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCR11 Gene

Publications for UQCR11 Gene

  1. Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences. (PMID: 9161705) Islam MM … Tanaka M (Biochemistry and molecular biology international 1997) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58

Products for UQCR11 Gene

Sources for UQCR11 Gene

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