UQCR10 Gene
protein-coding GIFtS: 55
GCID: GC22P030163
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ubiquinol-cytochrome c reductase, complex III subunit X
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Aliases
for UQCR10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquinol-Cytochrome C Reductase, Complex III Subunit X1 2 | | HSPC1512 | | UCRC1 2 3 5 | | Cytochrome B-C1 Complex Subunit 92 | | HSPC0511 2 | | Cytochrome C1, Nonheme 7kDa Protein2 | | QCR91 2 | | Ubiquinol-Cytochrome C Reductase Complex (7.2 KD)2 | | UCCR7.21 2 | | Ubiquinol-Cytochrome C Reductase, Complex III Subunit X, 7.2kDa2 | | Cytochrome C1 Non-Heme 7 KDa Protein2 3 | | Complex III Subunit 93 | | Ubiquinol-Cytochrome C Reductase Complex 7.2 KDa Protein2 3 | | Complex III Subunit X3 |
Export aliases for UQCR10 gene to outside databasesPrevious GC identifer: GC22P013126 |
Summaries
for UQCR10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UQCR10:
UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middlesegment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 (PubMed8592474)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: QCR9_HUMAN, Q9UDW1Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex),which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity)
Gene Wiki entry for UQCR10 (UCRC)
|
Genomic Views
for UQCR10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for UQCR10
Other transcription factors
Search SABiosciences Chromatin IP Primers for UQCR10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UQCR10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2UQCR10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P030163: view genomic region
(about GC identifiers)
Start:
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30,163,358 bp from pter |
End:
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30,166,402 bp from pter |
Size:
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3,045 bases |
Orientation:
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plus strand |
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Proteins
for UQCR10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: QCR9_HUMAN, Q9UDW1 (See
protein sequence)Recommended Name: Cytochrome b-c1 complex subunit 9 Size: 63 amino acids; 7308 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1),2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8,UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Subcellular location: Mitochondrion inner membrane (By similarity)
Secondary accessions: B5MCM5 Q9T2V6Alternative splicing: 2 isoforms: Q9UDW1-1 Q9UDW1-2 Explore the universe of human proteins at neXtProt for UQCR10: NX_Q9UDW1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UDW1
UQCR10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001003684.1 NP_037519.2
ENSEMBL proteins: ENSP00000332887 ENSP00000384962 Reactome Protein details: Q9UDW1
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UQCR10 for ontologies About GeneDecksing
UQCR10 Antibody Products:
Assay Products for UQCR10: |
Protein
Domains /
Families
for UQCR10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UQCR10 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UDW1ProtoNet protein and cluster: Q9UDW1 1 Blocks protein family: IPB008027 Ubiquinol-cytochrome C reductase
UniProtKB/Swiss-Prot: QCR9_HUMAN, Q9UDW1Similarity: Belongs to the UQCR10/QCR9 family |
Function
for UQCR10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: QCR9_HUMAN, Q9UDW1Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex),which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UQCR10 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCR10 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008121 | ubiquinol-cytochrome-c reductase activity |
NAS | 8592474 |
UQCR10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UQCR10:
|
Pathways & Interactions
for UQCR10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | | | 3 | Cardiac muscle contraction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for UQCR10
4 
Reactome Pathways for UQCR10
5/6 
Kegg Pathways (Kegg details for UQCR10) (see all 6):
UQCR10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UQCR10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/97 Interacting proteins for UQCR10 (Q9UDW13 ENSP000003328874) via UniProtKB, MINT, STRING, and/or I2D (see all 97)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
NAS | 8592474 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
UQCR10 for ontologies About GeneDecksing
|
Drugs & Compounds
for UQCR10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UQCR10 for compounds About GeneDecksing
 Browse Tocris compounds for UQCR10
4 HMDB Compounds for UQCR10 About this table
9 DrugBank Compounds for UQCR10 About this table
1 Novoseek chemical compound relationship for UQCR10 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ubiquinone |
71.7 |
1 |
8394321 (1) |
Search CenterWatch for drugs/clinical trials and news about UQCR10 / QCR9
|
Transcripts
for UQCR10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UQCR10 gene (2 alternative transcripts): NM_001003684.1 NM_013387.3 Unigene Cluster for UQCR10: Ubiquinol-cytochrome c reductase, complex III subunit X Hs.284292 [show with all ESTs]Unigene Representative Sequence: BF9651312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000330029(uc003agq.1 uc003agp.1) ENST00000401406
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UQCR10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UQCR10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UQCR10 (NM_001003684) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UQCR10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCR10 |
Additional cDNA sequence: AB028598.1 AF112217.1 AF161468.1 AF161500.1 AF161536.1 AK225973.1 BC005402.1 BC015971.1 11 DOTS entries: DT.448420 DT.97763060 DT.95210575 DT.100823244 DT.100823240 DT.120662747 DT.120662742 DT.120662750 DT.120662761 DT.92447211 DT.95169600 24/327 AceView cDNA sequences (see all 327): BQ101093 CB857246 AW341467 AA813796 BM873565 BM709426 BM990708 CB122925 NM_001003684 BM725005 CD674029 F24036 BI754905 BM769268 AA602798 AW292831 BM680219 BU581481 CD106970 BU581178 AA577152 AI417475 AV653190 CD674133
GeneLoc Exon Structure
|
Expression
for UQCR10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UQCR10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAGGAAAT
About this image
See UQCR10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UQCR10
SOURCE GeneReport for Unigene cluster: Hs.284292
SABiosciences Custom PCR Arrays for UQCR10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UQCR10
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCR10 |
Orthologs
for UQCR10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UQCR10 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for UQCR10 (if available)
TreeFam Gene Tree for UQCR10 (if available) |
Paralogs
for UQCR10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UQCR10 gene
UQCR10 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UQCR10
PGOHUM00000263340
|
Genomic Variants
for UQCR10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UQCR10 (30163358 - 30166402 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UQCR10
1 CNV: 10623 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UQCR10 |
|
Disorders
/ Diseases
for UQCR10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UQCR10 for disorders About GeneDecksing
OMIM gene information: 610843
OMIM disorders: --
3  diseases for UQCR10: About MalaCardshuntington's disease parkinson's disease hypoxia
Human Genome Epidemiology (HuGE) Navigator: UQCR10 (1 document)
Export disorders for UQCR10 gene to outside databases
|
Publications
for UQCR10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UQCR10 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with UQCR10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Ubiquinol-cytochrome-c reductase from human and bovine mitochondria. (PubMed id 8592474)1, 2 Schaegger H.... von Jagow G. (1995)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (PubMed id 22277967)1 Calvo S.E.... Mootha V.K. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
|
External Searches for UQCR10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UQCR10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UQCR10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UQCR10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UQCR10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UQCR10 gene:
Search GeneIP for patents involving UQCR10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UQCR10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCR10 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UQCR10 |
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