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Aliases for UQCR10 Gene

Aliases for UQCR10 Gene

  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit X 2 3 5
  • Ubiquinol-Cytochrome C Reductase Complex 7.2 KDa Protein 3 4
  • Cytochrome C1 Non-Heme 7 KDa Protein 3 4
  • Complex III Subunit X 2 4
  • Complex III Subunit 9 2 4
  • UCRC 3 4
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit X, 7.2kDa 3
  • Ubiquinol-Cytochrome C Reductase Complex (7.2 KD) 3
  • Cytochrome C1, Nonheme 7kDa Protein 3
  • Ubiquinol-Cytochrome C Reductase 2
  • HSPC051 3
  • HSPC119 3
  • HSPC151 3
  • UCCR7.2 3
  • 7.2kDa 2
  • QCR9 3

External Ids for UQCR10 Gene

Previous GeneCards Identifiers for UQCR10 Gene

  • GC22P030163
  • GC22P013126

Summaries for UQCR10 Gene

Entrez Gene Summary for UQCR10 Gene

  • UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UQCR10 Gene

UQCR10 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit X) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot for UQCR10 Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).

Gene Wiki entry for UQCR10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCR10 Gene

Genomics for UQCR10 Gene

Genomic Location for UQCR10 Gene

Chromosome:
22
Start:
29,767,369 bp from pter
End:
29,770,413 bp from pter
Size:
3,045 bases
Orientation:
Plus strand

Genomic View for UQCR10 Gene

Genes around UQCR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UQCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UQCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCR10 Gene

No data available for Regulatory Elements for UQCR10 Gene

Proteins for UQCR10 Gene

  • Protein details for UQCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDW1-QCR9_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 9
    Protein Accession:
    Q9UDW1
    Secondary Accessions:
    • B5MCM5
    • Q9T2V6

    Protein attributes for UQCR10 Gene

    Size:
    63 amino acids
    Molecular mass:
    7308 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Alternative splice isoforms for UQCR10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UQCR10 Gene

Proteomics data for UQCR10 Gene at MOPED

Post-translational modifications for UQCR10 Gene

No Post-translational modifications

Other Protein References for UQCR10 Gene

No data available for DME Specific Peptides for UQCR10 Gene

Domains & Families for UQCR10 Gene

Protein Domains for UQCR10 Gene

Suggested Antigen Peptide Sequences for UQCR10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UDW1

UniProtKB/Swiss-Prot:

QCR9_HUMAN :
  • Belongs to the UQCR10/QCR9 family.
Family:
  • Belongs to the UQCR10/QCR9 family.
genes like me logo Genes that share domains with UQCR10: view

Function for UQCR10 Gene

Molecular function for UQCR10 Gene

UniProtKB/Swiss-Prot Function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).
genes like me logo Genes that share phenotypes with UQCR10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UQCR10 Gene

Localization for UQCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCR10 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCR10 Gene COMPARTMENTS Subcellular localization image for UQCR10 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UQCR10: view

Pathways & Interactions for UQCR10 Gene

genes like me logo Genes that share pathways with UQCR10: view

Gene Ontology (GO) - Biological Process for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034551 mitochondrial respiratory chain complex III assembly IBA --
GO:0044281 small molecule metabolic process TAS --
GO:1902600 hydrogen ion transmembrane transport NAS 8592474
genes like me logo Genes that share ontologies with UQCR10: view

No data available for SIGNOR curated interactions for UQCR10 Gene

Drugs & Compounds for UQCR10 Gene

(12) Drugs for UQCR10 Gene - From: HMDB, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ubiquinone-2 Experimental Pharma Target 0
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE Experimental Pharma Target 0

(1) Additional Compounds for UQCR10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
genes like me logo Genes that share compounds with UQCR10: view

Transcripts for UQCR10 Gene

Unigene Clusters for UQCR10 Gene

Ubiquinol-cytochrome c reductase, complex III subunit X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UQCR10 Gene

No ASD Table

Relevant External Links for UQCR10 Gene

GeneLoc Exon Structure for
UQCR10
ECgene alternative splicing isoforms for
UQCR10

Expression for UQCR10 Gene

mRNA expression in normal human tissues for UQCR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UQCR10 Gene

This gene is overexpressed in Nasal epithelium (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCR10 Gene



SOURCE GeneReport for Unigene cluster for UQCR10 Gene Hs.284292

genes like me logo Genes that share expression patterns with UQCR10: view

Protein tissue co-expression partners for UQCR10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UQCR10 Gene

Orthologs for UQCR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for UQCR10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UQCR10 35
  • 91.53 (n)
  • 87.3 (a)
UQCR10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UQCR10 35
  • 91.01 (n)
  • 85.71 (a)
UQCR10 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uqcr10 35
  • 85.19 (n)
  • 84.13 (a)
Uqcr10 16
Uqcr10 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UQCR10 35
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Uqcr10 35
  • 84.66 (n)
  • 80.95 (a)
chicken
(Gallus gallus)
Aves UQCR10 35
  • 79.17 (n)
  • 75 (a)
UQCR10 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UQCR10 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uqcr10 35
  • 66.67 (n)
  • 73.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta ox 36
  • 55 (a)
OneToOne
Species with no ortholog for UQCR10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UQCR10 Gene

ENSEMBL:
Gene Tree for UQCR10 (if available)
TreeFam:
Gene Tree for UQCR10 (if available)

Paralogs for UQCR10 Gene

Pseudogenes.org Pseudogenes for UQCR10 Gene

genes like me logo Genes that share paralogs with UQCR10: view

No data available for Paralogs for UQCR10 Gene

Variants for UQCR10 Gene

Sequence variations from dbSNP and Humsavar for UQCR10 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_052444 -
rs140139 -- 29,769,423(+) accca(A/G)gaggc intron-variant
rs140140 -- 29,770,448(+) gctgc(A/G)tgcag downstream-variant-500B
rs6006242 -- 29,770,641(+) CCAAG(A/G)TGATA downstream-variant-500B
rs34252338 -- 29,770,407(+) TGAAG(-/A)AATTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UQCR10 Gene

Variant ID Type Subtype PubMed ID
nsv515720 CNV Gain+Loss 19592680
nsv817987 CNV Loss 17921354
esv2724127 CNV Deletion 23290073
nsv3590 CNV Insertion 18451855

Variation tolerance for UQCR10 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.14; 80.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UQCR10 Gene

HapMap Linkage Disequilibrium report
UQCR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCR10 Gene

Disorders for UQCR10 Gene

Relevant External Links for UQCR10

Genetic Association Database (GAD)
UQCR10
Human Genome Epidemiology (HuGE) Navigator
UQCR10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UQCR10

No disorders were found for UQCR10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UQCR10 Gene

Publications for UQCR10 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (PMID: 22277967) Calvo S.E. … Mootha V.K. (Sci. Transl. Med. 2012) 3

Products for UQCR10 Gene

Sources for UQCR10 Gene

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