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Aliases for UQCR10 Gene

Aliases for UQCR10 Gene

  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit X 2 3
  • UCRC 3 4 6
  • Ubiquinol-Cytochrome C Reductase Complex 7.2 KDa Protein 3 4
  • Cytochrome C1 Non-Heme 7 KDa Protein 3 4
  • Complex III Subunit X 2 4
  • Complex III Subunit 9 2 4
  • Ubiquinol-Cytochrome C Reductase, Complex III Subunit X, 7.2kDa 3
  • Ubiquinol-Cytochrome C Reductase Complex (7.2 KD) 3
  • Cytochrome C1, Nonheme 7kDa Protein 3
  • Cytochrome B-C1 Complex Subunit 9 3
  • Ubiquinol-Cytochrome C Reductase 2
  • HSPC051 3
  • HSPC119 3
  • HSPC151 3
  • UCCR7.2 3
  • 7.2kDa 2
  • QCR9 3

External Ids for UQCR10 Gene

Previous GeneCards Identifiers for UQCR10 Gene

  • GC22P030163
  • GC22P013126

Summaries for UQCR10 Gene

Entrez Gene Summary for UQCR10 Gene

  • UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UQCR10 Gene

UQCR10 (Ubiquinol-Cytochrome C Reductase, Complex III Subunit X) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot for UQCR10 Gene

  • This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).

Gene Wiki entry for UQCR10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UQCR10 Gene

Genomics for UQCR10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UQCR10 Gene

Start:
29,767,369 bp from pter
End:
29,770,413 bp from pter
Size:
3,045 bases
Orientation:
Plus strand

Genomic View for UQCR10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UQCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UQCR10 Gene

No data available for Regulatory Elements for UQCR10 Gene

Proteins for UQCR10 Gene

  • Protein details for UQCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDW1-QCR9_HUMAN
    Recommended name:
    Cytochrome b-c1 complex subunit 9
    Protein Accession:
    Q9UDW1
    Secondary Accessions:
    • B5MCM5
    • Q9T2V6

    Protein attributes for UQCR10 Gene

    Size:
    63 amino acids
    Molecular mass:
    7308 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)

    Alternative splice isoforms for UQCR10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UQCR10 Gene

Proteomics data for UQCR10 Gene at MOPED

Post-translational modifications for UQCR10 Gene

No Post-translational modifications

Other Protein References for UQCR10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UQCR10 Gene

Domains for UQCR10 Gene

Gene Families for UQCR10 Gene

HGNC:
  • comIII :Mitochondrial respiratory chain complex / Complex III

Protein Domains for UQCR10 Gene

Suggested Antigen Peptide Sequences for UQCR10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UDW1

UniProtKB/Swiss-Prot:

QCR9_HUMAN :
  • Q9UDW1
Family:
  • Belongs to the UQCR10/QCR9 family.
genes like me logo Genes that share domains with UQCR10: view

Function for UQCR10 Gene

Molecular function for UQCR10 Gene

UniProtKB/Swiss-Prot Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).

Gene Ontology (GO) - Molecular Function for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008121 ubiquinol-cytochrome-c reductase activity NAS 8592474
genes like me logo Genes that share ontologies with UQCR10: view

Phenotypes for UQCR10 Gene

GenomeRNAi human phenotypes for UQCR10:
genes like me logo Genes that share phenotypes with UQCR10: view

Animal Model Products

CRISPR Products

miRNA for UQCR10 Gene

miRTarBase miRNAs that target UQCR10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UQCR10 Gene

Localization for UQCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UQCR10 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UQCR10 Gene COMPARTMENTS Subcellular localization image for UQCR10 gene
Compartment Confidence
mitochondrion 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005750 mitochondrial respiratory chain complex III IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UQCR10: view

Pathways for UQCR10 Gene

genes like me logo Genes that share pathways with UQCR10: view

Gene Ontology (GO) - Biological Process for UQCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c NAS 8592474
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:1902600 hydrogen ion transmembrane transport NAS 8592474
genes like me logo Genes that share ontologies with UQCR10: view

Compounds for UQCR10 Gene

(4) HMDB Compounds for UQCR10 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
QH2
  • CoQH2
56275-39-9
Ubiquinone Q1
  • Coenzyme Q
727-81-1
Ubiquinone Q2
  • 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
606-06-4

(1) Novoseek inferred chemical compound relationships for UQCR10 Gene

Compound -log(P) Hits PubMed IDs
ubiquinone 71.7 1
genes like me logo Genes that share compounds with UQCR10: view

Transcripts for UQCR10 Gene

mRNA/cDNA for UQCR10 Gene

Unigene Clusters for UQCR10 Gene

Ubiquinol-cytochrome c reductase, complex III subunit X:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UQCR10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UQCR10 Gene

No ASD Table

Relevant External Links for UQCR10 Gene

GeneLoc Exon Structure for
UQCR10
ECgene alternative splicing isoforms for
UQCR10

Expression for UQCR10 Gene

mRNA expression in normal human tissues for UQCR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UQCR10 Gene

SOURCE GeneReport for Unigene cluster for UQCR10 Gene Hs.284292

genes like me logo Genes that share expressions with UQCR10: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UQCR10 Gene

Orthologs for UQCR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for UQCR10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UQCR10 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia UQCR10 35
  • 91.53 (n)
  • 87.3 (a)
UQCR10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UQCR10 35
  • 91.01 (n)
  • 85.71 (a)
UQCR10 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uqcr10 35
  • 85.19 (n)
  • 84.13 (a)
Uqcr10 16
Uqcr10 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uqcr10 35
  • 84.66 (n)
  • 80.95 (a)
chicken
(Gallus gallus)
Aves UQCR10 35
  • 79.17 (n)
  • 75 (a)
UQCR10 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UQCR10 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uqcr10 35
  • 66.67 (n)
  • 73.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta ox 36
  • 55 (a)
OneToOne
Species with no ortholog for UQCR10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UQCR10 Gene

ENSEMBL:
Gene Tree for UQCR10 (if available)
TreeFam:
Gene Tree for UQCR10 (if available)

Paralogs for UQCR10 Gene

Pseudogenes.org Pseudogenes for UQCR10 Gene

genes like me logo Genes that share paralogs with UQCR10: view

No data available for Paralogs for UQCR10 Gene

Variants for UQCR10 Gene

Sequence variations from dbSNP and Humsavar for UQCR10 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs140139 -- 29,769,423(+) accca(A/G)gaggc intron-variant
rs140140 -- 29,770,448(+) gctgc(A/G)tgcag downstream-variant-500B
rs5763478 -- 29,770,382(+) aaaat(C/T)tcata utr-variant-3-prime
rs6006242 -- 29,770,641(+) CCAAG(A/G)TGATA downstream-variant-500B
rs34252338 -- 29,770,407(+) TGAAG(-/A)AATTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UQCR10 Gene

Variant ID Type Subtype PubMed ID
nsv515720 CNV Gain+Loss 19592680
nsv817987 CNV Loss 17921354
esv2724127 CNV Deletion 23290073
nsv3590 CNV Insertion 18451855

Relevant External Links for UQCR10 Gene

HapMap Linkage Disequilibrium report
UQCR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UQCR10 Gene

Disorders for UQCR10 Gene

Relevant External Links for UQCR10

Genetic Association Database (GAD)
UQCR10
Human Genome Epidemiology (HuGE) Navigator
UQCR10
genes like me logo Genes that share disorders with UQCR10: view

No data available for UniProtKB/Swiss-Prot for UQCR10 Gene

Publications for UQCR10 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Ubiquinol-cytochrome-c reductase from human and bovine mitochondria. (PMID: 8592474) Schaegger H. … von Jagow G. (Methods Enzymol. 1995) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for UQCR10 Gene

Sources for UQCR10 Gene

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