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UQCR10 Gene

protein-coding   GIFtS: 56
GCID: GC22P030163

Ubiquinol-Cytochrome C Reductase, Complex III Subunit X

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquinol-Cytochrome C Reductase, Complex III Subunit X1 2     HSPC0512
UCRC2 3 5     HSPC1512
Complex III Subunit 91 3     QCR92
Complex III Subunit X1 3     UCCR7.22
Cytochrome C1 Non-Heme 7 KDa Protein2 3     Cytochrome B-C1 Complex Subunit 92
Ubiquinol-Cytochrome C Reductase Complex 7.2 KDa Protein2 3     Cytochrome C1, Nonheme 7kDa Protein2
7.2kDa1     Ubiquinol-Cytochrome C Reductase Complex (7.2 KD)2
Ubiquinol-Cytochrome C Reductase1     Ubiquinol-Cytochrome C Reductase, Complex III Subunit X, 7.2kDa2

External Ids:    HGNC: 308631   Entrez Gene: 297962   Ensembl: ENSG000001840767   OMIM: 6108435   UniProtKB: Q9UDW13   

Export aliases for UQCR10 gene to outside databases

Previous GC identifer: GC22P013126


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UQCR10 Gene:
UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the
middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 (PubMed
8592474)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UQCR10 Gene:
UQCR10 (ubiquinol-cytochrome c reductase, complex III subunit X) is a protein-coding gene. Diseases associated with UQCR10 include huntington's disease, and hypoxia. GO annotations related to this gene include ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot: QCR9_HUMAN, Q9UDW1
Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By
similarity)

Gene Wiki entry for UQCR10 (UCRC) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for UQCR10
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUQCR10 promoter sequence
   Search Chromatin IP Primers for UQCR10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UQCR10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

UQCR10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UQCR10 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P030163:  view genomic region     (about GC identifiers)

Start:
30,163,358 bp from pter      End:
30,166,402 bp from pter
Size:
3,045 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: QCR9_HUMAN, Q9UDW1 (See protein sequence)
Recommended Name: Cytochrome b-c1 complex subunit 9  
Size: 63 amino acids; 7308 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Secondary accessions: B5MCM5 Q9T2V6
Alternative splicing: 2 isoforms:  Q9UDW1-1   Q9UDW1-2   

Explore the universe of human proteins at neXtProt for UQCR10: NX_Q9UDW1

Explore proteomics data for UQCR10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UQCR10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003684.1  NP_037519.2  

    ENSEMBL proteins: 
     ENSP00000332887   ENSP00000384962  
    Reactome Protein details: Q9UDW1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIII: Mitochondrial respiratory chain complex / Complex III

    1 InterPro protein domain:
     IPR008027 QCR9

    Graphical View of Domain Structure for InterPro Entry Q9UDW1

    ProtoNet protein and cluster: Q9UDW1

    1 Blocks protein domain: IPB008027 Ubiquinol-cytochrome C reductase

    UniProtKB/Swiss-Prot: QCR9_HUMAN, Q9UDW1
    Similarity: Belongs to the UQCR10/QCR9 family


    UQCR10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QCR9_HUMAN, Q9UDW1
    Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1
    complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008121ubiquinol-cytochrome-c reductase activity NAS8592474
         
    UQCR10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UQCR10:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UQCR10
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    miRTarBase miRNAs that target UQCR10:
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    Block miRNA regulation of human, mouse, rat UQCR10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UQCR10 (see all 12):
    hsa-miR-569 hsa-miR-498 hsa-miR-922 hsa-miR-1237 hsa-miR-578 hsa-miR-1285 hsa-miR-1248 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidUQCR10 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    QCR9_HUMAN, Q9UDW1: Mitochondrion inner membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol1
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005740mitochondrial envelope ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005750mitochondrial respiratory chain complex III IEA--

    UQCR10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UQCR10 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for UQCR10
        Electron Transport Chain

    1 Reactome Pathway for UQCR10
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for UQCR10) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    UQCR10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UQCR10
    Interactions:

        Search GeneGlobe Interaction Network for UQCR10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UQCR10 (Q9UDW13 ENSP000003328874) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYC1P085743, ENSP000003171594I2D: score=2 STRING: ENSP00000317159
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    UQCRC1P319303, ENSP000002034074I2D: score=1 STRING: ENSP00000203407
    COX4I1ENSP000002534524STRING: ENSP00000253452
    COX7A2LENSP000002343014STRING: ENSP00000234301
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c NAS8592474
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:1902600hydrogen ion transmembrane transport NAS8592474

    UQCR10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UQCR10 (QCR9)

    4 HMDB Compounds for UQCR10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    9 DrugBank Compounds for UQCR10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    UBIQUINONE-2-- --target--10592235

    1 Novoseek inferred chemical compound relationship for UQCR10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ubiquinone 71.7 1 8394321 (1)



    UQCR10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UQCR10 gene (2 alternative transcripts): 
    NM_001003684.1  NM_013387.3  

    Unigene Cluster for UQCR10:

    Ubiquinol-cytochrome c reductase, complex III subunit X
    Hs.284292  [show with all ESTs]
    Unigene Representative Sequence: BF965131
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330029(uc003agq.1 uc003agp.1) ENST00000401406

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    hsa-miR-569 hsa-miR-498 hsa-miR-922 hsa-miR-1237 hsa-miR-578 hsa-miR-1285 hsa-miR-1248 hsa-miR-3922-3p
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    Additional mRNA sequence: 

    AB028598.1 AF112217.1 AF161468.1 AF161500.1 AF161536.1 AK225973.1 BC005402.1 BC015971.1 

    11 DOTS entries:

    DT.448420  DT.97763060  DT.95210575  DT.100823244  DT.100823240  DT.120662747  DT.120662742  DT.120662750 
    DT.120662761  DT.92447211  DT.95169600 

    Selected AceView cDNA sequences (see all 327):

    AA813796 BE274514 BM930261 CD674029 AW341467 CA311834 BM873383 BM725005 
    CB857246 T54639 AJ709863 AA602798 CB118062 AW292831 AW163418 NM_001003684 
    BM853417 NM_013387 BG286883 BQ100801 BM680219 BM769268 BF920630 BI754905 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UQCR10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGGAAAT
    UQCR10 Expression
    About this image


    UQCR10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    UQCR10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UQCR10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.284292
        Custom PCR Arrays for UQCR10
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UQCR10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UQCR10 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uqcr101 , 5 ubiquinol-cytochrome c reductase, complex III subunit more1, 5 85.19(n)1
    84.13(a)1
      11 (2.96 cM)5
    661521  NM_197979.21  NP_932096.11 
     47019735 
    chicken
    (Gallus gallus)
    Aves UQCR101 ubiquinol-cytochrome c reductase, complex III subunit more 79.17(n)
    75(a)
      770937  XM_001234249.3  XP_001234250.1 
    lizard
    (Anolis carolinensis)
    Reptilia UQCR106
    ubiquinol-cytochrome c reductase, complex III subu...
    63(a)
    1 ↔ 1
    GL344849.1(3916-8473)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB201180.22   -- 74.67(n)    CB201180.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta ox6
    oxen
    55(a)
    1 ↔ 1
    2R(8644644-8645028)


    ENSEMBL Gene Tree for UQCR10 (if available)
    TreeFam Gene Tree for UQCR10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UQCR10 gene

    UQCR10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UQCR10
    PGOHUM00000263340


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UQCR10 (see all 36)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440524531,2
    C--13130461(+) TCAGCC/TTCCCA 2 -- ds50010--------
    rs3755934881,2
    C--13130484(+) TACAGA/GGTGCG 2 -- ds50010--------
    rs1144766541,2
    C,F--13130489(+) GTGTGC/TGCCAC 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1162231161,2
    F--30165345(+) AATTAG/CCCGGG 2 -- int11Minor allele frequency- C:0.04WA 118
    rs1454708011,2
    C--30165355(+) GTAGCA/GCATAC 2 -- int10--------
    rs1401391,2
    C,F,A--30165412(+) acccaG/Agaggc 2 -- int16Minor allele frequency- A:0.29MN NA WA CSA 101
    rs1127173341,2
    C--30165665(+) AATGCA/GGAAGC 2 -- spa10--------
    rs1998102621,2
    --30165686(+) CATCAA/GGCACA 3 K R mis1 ut310--------
    rs2012661991,2
    C--30165696(+) AAGTAA/TGAGAA 3 * Y stg1 ut310--------
    rs1917464071,2
    --30165804(+) CAAGGG/TACTCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for UQCR10 (30163358 - 30166402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UQCR10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724127CNV Deletion23290073
    nsv3590CNV Insertion18451855
    nsv817987CNV Loss17921354
    nsv515720CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UQCR10
    DNA2.0 Custom Variant and Variant Library Synthesis for UQCR10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610843    OMIM disorders: --

    6 diseases for UQCR10:    
    About MalaCards
    huntington's disease    hypoxia    fatty liver disease    parkinson's disease
    alzheimer's disease    liver disease


    UQCR10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): UQCR10
    Human Genome Epidemiology (HuGE) Navigator: UQCR10 (1 document)

    Export disorders for UQCR10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UQCR10 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with UQCR10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    5. Ubiquinol-cytochrome-c reductase from human and bovine mitochondria. (PubMed id 8592474)1, 2 Schaegger H.... von Jagow G. (Methods Enzymol. 1995)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (PubMed id 22277967)1 Calvo S.E.... Mootha V.K. (Sci. Transl. Med. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29796 HGNC: 30863 AceView: HSPC051 Ensembl:ENSG00000184076 euGenes: HUgn29796
    ECgene: UQCR10 Kegg: 29796 H-InvDB: UQCR10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UQCR10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UQCR10 gene:
    Search GeneIP for patents involving UQCR10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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