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Aliases for UPRT Gene

Aliases for UPRT Gene

  • Uracil Phosphoribosyltransferase Homolog 2 3 5
  • Uracil Phosphoribosyltransferase (FUR1) Homolog (S. Cerevisiae) 2
  • Uracil Phosphoribosyltransferase (FUR1) Homolog 3
  • UMP Pyrophosphorylase 3
  • RP11-311P8.3 3
  • EC 63
  • EC 2.4.2 63
  • UPRTase 3
  • FUR1 3
  • UPP 3

External Ids for UPRT Gene

Previous GeneCards Identifiers for UPRT Gene

  • GC0XP074411
  • GC0XP074412
  • GC0XP074493
  • GC0XP068128

Summaries for UPRT Gene

Entrez Gene Summary for UPRT Gene

  • This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]

GeneCards Summary for UPRT Gene

UPRT (Uracil Phosphoribosyltransferase Homolog) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG).

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPRT Gene

Genomics for UPRT Gene

Regulatory Elements for UPRT Gene

Enhancers for UPRT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UPRT on UCSC Golden Path with GeneCards custom track

Promoters for UPRT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UPRT on UCSC Golden Path with GeneCards custom track

Genomic Location for UPRT Gene

75,274,059 bp from pter
75,304,897 bp from pter
30,839 bases
Plus strand

Genomic View for UPRT Gene

Genes around UPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPRT Gene

Proteins for UPRT Gene

  • Protein details for UPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uracil phosphoribosyltransferase homolog
    Protein Accession:
    Secondary Accessions:
    • Q5JRL1
    • Q5JRL3
    • Q68DN0
    • Q96MW2

    Protein attributes for UPRT Gene

    309 amino acids
    Molecular mass:
    33786 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UPRT Gene


neXtProt entry for UPRT Gene

Proteomics data for UPRT Gene at MOPED

Post-translational modifications for UPRT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UPRT Gene

Domains & Families for UPRT Gene

Protein Domains for UPRT Gene


Suggested Antigen Peptide Sequences for UPRT Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPRTase family.
  • Belongs to the UPRTase family.
genes like me logo Genes that share domains with UPRT: view

No data available for Gene Families for UPRT Gene

Function for UPRT Gene

Enzyme Numbers (IUBMB) for UPRT Gene

Gene Ontology (GO) - Molecular Function for UPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with UPRT: view
genes like me logo Genes that share phenotypes with UPRT: view

Animal Model Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UPRT Gene

Localization for UPRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPRT Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for UPRT Gene COMPARTMENTS Subcellular localization image for UPRT gene
Compartment Confidence
cytosol 5
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for UPRT Gene

Pathways & Interactions for UPRT Gene

genes like me logo Genes that share pathways with UPRT: view

Pathways by source for UPRT Gene

2 KEGG pathways for UPRT Gene

Gene Ontology (GO) - Biological Process for UPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process IBA --
GO:0007595 lactation IEA --
GO:0032868 response to insulin IEA --
genes like me logo Genes that share ontologies with UPRT: view

No data available for SIGNOR curated interactions for UPRT Gene

Drugs & Compounds for UPRT Gene

(4) Drugs for UPRT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0
Phosphoribosyl pyrophosphate Experimental Pharma 0
Uracil Experimental Pharma 0
Uridine-5'-Monophosphate Experimental Pharma 0
genes like me logo Genes that share compounds with UPRT: view

Transcripts for UPRT Gene

Unigene Clusters for UPRT Gene

Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UPRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - -

Relevant External Links for UPRT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UPRT Gene

mRNA expression in normal human tissues for UPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UPRT Gene

This gene is overexpressed in Urine (49.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UPRT Gene

SOURCE GeneReport for Unigene cluster for UPRT Gene Hs.91612

mRNA Expression by UniProt/SwissProt for UPRT Gene

Tissue specificity: Highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle.
genes like me logo Genes that share expression patterns with UPRT: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for UPRT Gene

Orthologs for UPRT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UPRT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UPRT 35
  • 91.72 (n)
  • 88.89 (a)
  • 89 (a)
(Canis familiaris)
Mammalia UPRT 35
  • 90.43 (n)
  • 86.8 (a)
  • 85 (a)
(Mus musculus)
Mammalia Uprt 35
  • 88.67 (n)
  • 86.41 (a)
Uprt 16
Uprt 36
  • 85 (a)
(Pan troglodytes)
Mammalia UPRT 35
  • 99.46 (n)
  • 99.68 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Uprt 35
  • 88.35 (n)
  • 85.44 (a)
(Monodelphis domestica)
Mammalia UPRT 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia UPRT 36
  • 87 (a)
(Gallus gallus)
Aves UPRT 35
  • 76.93 (n)
  • 81.52 (a)
  • 98 (a)
(Anolis carolinensis)
Reptilia UPRT 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4444 35
uprt 35
  • 78.16 (n)
  • 92.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.31769 35
(Danio rerio)
Actinopterygii Dr.11713 35
uprt 35
  • 70.43 (n)
  • 79.77 (a)
uprt 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007111 35
  • 58.95 (n)
  • 67.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5537 35
  • 60.29 (n)
  • 66.03 (a)
CG5537 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea C47B2.2 35
  • 55.11 (n)
  • 53.27 (a)
C47B2.2 36
  • 47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR052C 35
  • 53.51 (n)
  • 52.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22903g 35
  • 51.66 (n)
  • 49.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FUR1 35
  • 55.68 (n)
  • 53.07 (a)
FUR1 36
  • 46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01446 35
  • 55.14 (n)
  • 51.89 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1B3.01c 35
  • 55.56 (n)
  • 50.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3454 36
  • 61 (a)
Species with no ortholog for UPRT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UPRT Gene

Gene Tree for UPRT (if available)
Gene Tree for UPRT (if available)

Paralogs for UPRT Gene

(2) SIMAP similar genes for UPRT Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UPRT: view

No data available for Paralogs for UPRT Gene

Variants for UPRT Gene

Sequence variations from dbSNP and Humsavar for UPRT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747743060 -- 75,303,965(+) GACAT(G/T)CTAGT nc-transcript-variant, utr-variant-3-prime
rs747744016 -- 75,276,978(+) AAAAT(A/G)TCTAT intron-variant
rs747833986 -- 75,302,366(+) AATAG(-/TA)TATAC intron-variant
rs747979921 -- 75,286,694(+) ACATA(C/T)CAATC intron-variant
rs747985650 -- 75,275,926(+) ACGAT(G/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UPRT Gene

Variant ID Type Subtype PubMed ID
esv25282 CNV Gain 19812545

Variation tolerance for UPRT Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UPRT Gene

Disorders for UPRT Gene

Relevant External Links for UPRT

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UPRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UPRT Gene

Publications for UPRT Gene

  1. UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan. (PMID: 26271729) Ghosh A.C. … O'Connor M.B. (Sci Rep 2015) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Specific targeting of prostate cancer cells in vitro by the suicide gene/prodrug system, uracil phosphoribosyltransferase/5-fluorouracil, under the control of prostate-specific membrane antigen promoter/enhancer. (PMID: 18626508) Zhao F.J. … Li H. (Prostate Cancer Prostatic Dis. 2009) 3

Products for UPRT Gene

Sources for UPRT Gene