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Aliases for UPRT Gene

Aliases for UPRT Gene

  • Uracil Phosphoribosyltransferase (FUR1) Homolog (S. Cerevisiae) 2 3
  • Uracil Phosphoribosyltransferase Homolog 3
  • UMP Pyrophosphorylase 3
  • RP11-311P8.3 3
  • EC 2.4.2.9 64
  • EC 2.4.2 64
  • UPRTase 3
  • FUR1 3
  • UPP 3

External Ids for UPRT Gene

Summaries for UPRT Gene

Entrez Gene Summary for UPRT Gene

  • This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]

GeneCards Summary for UPRT Gene

UPRT (Uracil Phosphoribosyltransferase (FUR1) Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (KEGG).

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPRT Gene

Genomics for UPRT Gene

Genomic Location for UPRT Gene

Start:
75,274,059 bp from pter
End:
75,304,897 bp from pter
Size:
30,839 bases
Orientation:
Plus strand

Genomic View for UPRT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPRT Gene

Regulatory Elements for UPRT Gene

Proteins for UPRT Gene

  • Protein details for UPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BW1-UPP_HUMAN
    Recommended name:
    Uracil phosphoribosyltransferase homolog
    Protein Accession:
    Q96BW1
    Secondary Accessions:
    • Q5JRL1
    • Q5JRL3
    • Q68DN0
    • Q96MW2

    Protein attributes for UPRT Gene

    Size:
    309 amino acids
    Molecular mass:
    33786 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UPRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UPRT Gene

Proteomics data for UPRT Gene at MOPED

Post-translational modifications for UPRT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UPRT Gene

Domains for UPRT Gene

Protein Domains for UPRT Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

UPP_HUMAN
Family:
  • Belongs to the UPRTase family.:
    • Q96BW1
genes like me logo Genes that share domains with UPRT: view

No data available for Gene Families for UPRT Gene

Function for UPRT Gene

Enzyme Numbers (IUBMB) for UPRT Gene

Gene Ontology (GO) - Molecular Function for UPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with UPRT: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UPRT Gene

Localization for UPRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPRT Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPRT Gene COMPARTMENTS Subcellular localization image for UPRT gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for UPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UPRT: view

Pathways for UPRT Gene

SuperPathways for UPRT Gene

genes like me logo Genes that share pathways with UPRT: view

Pathways by source for UPRT Gene

2 KEGG pathways for UPRT Gene

Gene Ontology (GO) - Biological Process for UPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006222 UMP biosynthetic process IEA --
GO:0007565 female pregnancy IEA --
GO:0007595 lactation IEA --
GO:0009116 nucleoside metabolic process --
GO:0032868 response to insulin IEA --
genes like me logo Genes that share ontologies with UPRT: view

Compounds for UPRT Gene

(1) HMDB Compounds for UPRT Gene

Compound Synonyms Cas Number PubMed IDs
Uracil
  • 2,4-Dihydroxypyrimidine
66-22-8
genes like me logo Genes that share compounds with UPRT: view

Transcripts for UPRT Gene

Unigene Clusters for UPRT Gene

Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UPRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - -
SP10:

Relevant External Links for UPRT Gene

GeneLoc Exon Structure for
UPRT
ECgene alternative splicing isoforms for
UPRT

Expression for UPRT Gene

mRNA expression in normal human tissues for UPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UPRT Gene

SOURCE GeneReport for Unigene cluster for UPRT Gene Hs.91612

mRNA Expression by UniProt/SwissProt for UPRT Gene

Q96BW1-UPP_HUMAN
Tissue specificity: Highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle.
genes like me logo Genes that share expressions with UPRT: view

Orthologs for UPRT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UPRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UPRT 36
  • 99.46 (n)
  • 99.68 (a)
UPRT 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UPRT 36
  • 91.72 (n)
  • 88.89 (a)
UPRT 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UPRT 36
  • 90.43 (n)
  • 86.8 (a)
UPRT 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uprt 36
  • 88.67 (n)
  • 86.41 (a)
Uprt 16
Uprt 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UPRT 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UPRT 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uprt 36
  • 88.35 (n)
  • 85.44 (a)
chicken
(Gallus gallus)
Aves UPRT 36
  • 76.93 (n)
  • 81.52 (a)
UPRT 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UPRT 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.31769 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4444 36
uprt 36
  • 78.16 (n)
  • 92.72 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11713 36
uprt 36
  • 70.43 (n)
  • 79.77 (a)
uprt 37
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007111 36
  • 58.95 (n)
  • 67.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5537 36
  • 60.29 (n)
  • 66.03 (a)
CG5537 37
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C47B2.2 36
  • 55.11 (n)
  • 53.27 (a)
C47B2.2 37
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR052C 36
  • 53.51 (n)
  • 52.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FUR1 36
  • 55.68 (n)
  • 53.07 (a)
FUR1 37
  • 46 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22903g 36
  • 51.66 (n)
  • 49.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01446 36
  • 55.14 (n)
  • 51.89 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1B3.01c 36
  • 55.56 (n)
  • 50.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3454 37
  • 61 (a)
OneToOne
Species with no ortholog for UPRT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UPRT Gene

ENSEMBL:
Gene Tree for UPRT (if available)
TreeFam:
Gene Tree for UPRT (if available)

Paralogs for UPRT Gene

Selected SIMAP similar genes for UPRT Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UPRT: view

No data available for Paralogs for UPRT Gene

Variants for UPRT Gene

Sequence variations from dbSNP and Humsavar for UPRT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs972561 -- 75,303,532(+) TAATT(A/G)TCTTA utr-variant-3-prime, nc-transcript-variant
rs1015169 -- 75,301,148(+) CCATT(C/T)TAATG intron-variant
rs1117328 -- 75,289,313(+) atgac(A/C)cagta intron-variant
rs1318846 -- 75,301,759(+) TGTTA(C/T)CACCA intron-variant
rs1353592 -- 75,296,122(-) GATTG(C/T)CACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UPRT Gene

Variant ID Type Subtype PubMed ID
esv25282 CNV Gain 19812545

Relevant External Links for UPRT Gene

HapMap Linkage Disequilibrium report
UPRT
Locus Specific Mutation Databases (LSDB)
UPRT

Disorders for UPRT Gene

Relevant External Links for UPRT

Genetic Association Database (GAD)
UPRT
genes like me logo Genes that share disorders with UPRT: view

No data available for UniProtKB/Swiss-Prot for UPRT Gene

Publications for UPRT Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Identification and characterization of human uracil phosphoribosyltransferase (UPRTase). (PMID: 17384901) Li J. … Mao Y. (J. Hum. Genet. 2007) 3 4

Products for UPRT Gene

Sources for UPRT Gene

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