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UPP2 Gene

protein-coding   GIFtS: 55
GCID: GC02P158736

Uridine Phosphorylase 2

  See UPP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Uridine Phosphorylase 21 2     UPASE22
UrdPase 22 3     Liver-Specific Uridine Phosphorylase2
UPase 22 3     Uridine Phosphorylase-22
UDRPASE22     EC 2.4.2.33
UP22     

External Ids:    HGNC: 230611   Entrez Gene: 1515312   Ensembl: ENSG000000070017   UniProtKB: O950453   

Export aliases for UPP2 gene to outside databases

Previous GC identifers: GC02P158815 GC02P159054 GC02P158677 GC02P158559 GC02P150739


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UPP2 Gene:
UPP2 (uridine phosphorylase 2) is a protein-coding gene. Diseases associated with UPP2 include timothy syndrome. GO annotations related to this gene include uridine phosphorylase activity. An important paralog of this gene is UPP1.

UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045
Function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or
deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue
of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and
thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as
substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UPP2 gene promoter:
         HOXA9B   HOXA9   AML1a   FOXF2   Meis-1b   GATA-1   FOXJ2 (long isoform)   FOXJ2   Meis-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUPP2 promoter sequence
   Search Chromatin IP Primers for UPP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.1   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q24.2

UPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P158736:  view genomic region     (about GC identifiers)

Start:
158,733,214 bp from pter      End:
158,992,666 bp from pter
Size:
259,453 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045 (See protein sequence)
Recommended Name: Uridine phosphorylase 2  
Size: 317 amino acids; 35527 Da
Sequence caution: Sequence=AAH33529.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for UPP2:
2XRF (3D)        3P0E (3D)        3P0F (3D)    
Secondary accessions: B3KV87
Alternative splicing: 2 isoforms:  O95045-1   O95045-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UPP2: NX_O95045

Explore proteomics data for UPP2 at MOPED


See UPP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001128570.1  NP_775491.1  

ENSEMBL proteins: 
 ENSP00000474090   ENSP00000005756   ENSP00000387230  
Reactome Protein details: O95045

UPP2 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR018017 Nucleoside_phosphorylase
 IPR010059 Uridine_phosphorylase_euk
 IPR018016 Nucleoside_phosphorylase_CS
 IPR000845 Nucleoside_phosphorylase_d

Graphical View of Domain Structure for InterPro Entry O95045

ProtoNet protein and cluster: O95045

1 Blocks protein domain: IPB000845 Purine and other phosphorylases

UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045
Similarity: Belongs to the PNP/UDP phosphorylase family


Find genes that share domains with UPP2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: UPP2_HUMAN, O95045
Function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or
deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue
of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and
thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as
substrates
Catalytic activity: Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
Enzyme regulation: A conditional disulfide bridge can form within the protein that dislocates a critical
phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme

     Enzyme Number (IUBMB): EC 2.4.2.31

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004850uridine phosphorylase activity IDA12849978
     
Find genes that share ontologies with UPP2           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for UPP2:
 Decreased POU5F1-GFP protein e 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UPP2
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UPP2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UPP2

miRNA
Products:
    
miRTarBase miRNAs that target UPP2:
hsa-let-7a-5p (MIRT052364)

Block miRNA regulation of human, mouse, rat UPP2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate UPP2 (see all 13):
hsa-miR-323-3p hsa-miR-3163 hsa-miR-668 hsa-miR-3607-3p hsa-miR-550a hsa-miR-448 hsa-miR-516b hsa-miR-944
SwitchGear 3'UTR luciferase reporter plasmidUPP2 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat UPP2

Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPP2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton5
cytosol5
mitochondrion2
nucleus2
golgi apparatus1
peroxisome1
plasma membrane1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005829cytosol TAS--
GO:0045098type III intermediate filament IDA11278417

Find genes that share ontologies with UPP2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for UPP2 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Pyrimidine metabolism
Fluoropyrimidine Activity0.69
Pyrimidine salvage reactions0.00
Fluoropyrimidine Pathway, Pharmacokinetics0.69
Pyrimidine catabolism0.00
Pyrimidine metabolism0.33
2Metabolism
Metabolism0.38
Metabolic pathways0.38
3superpathway of pyrimidine ribonucleosides degradation
superpathway of pyrimidine ribonucleosides degradation0.60
pyrimidine ribonucleosides degradation0.00
pyrimidine deoxyribonucleosides degradation0.33
4Purine metabolism (REACTOME)
Metabolism of nucleotides0.42
5Purine metabolism (KEGG)
Pyrimidine metabolism0.38


Find genes that share SuperPaths with UPP2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4 BioSystems Pathways for UPP2
    Fluoropyrimidine Activity
pyrimidine ribonucleosides degradation
pyrimidine deoxyribonucleosides degradation
superpathway of pyrimidine ribonucleosides degradation

2 Reactome Pathways for UPP2
    Pyrimidine catabolism
Pyrimidine salvage reactions

1 PharmGKB Pathway for UPP2
    Fluoropyrimidine Pathway, Pharmacokinetics

3 Kegg Pathways  (Kegg details for UPP2):
    Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways

UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045
Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route):
step 1/1

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UPP2
Interactions:

    Search GeneGlobe Interaction Network for UPP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

Selected Interacting proteins for UPP2 (O950453 ENSP000003872304) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

InteractantInteraction Details
GeneCardExternal ID(s)
VIMP086703, ENSP000002242374I2D: score=2 STRING: ENSP00000224237
CDAENSP000003642124STRING: ENSP00000364212
CYP2A13ENSP000003326794STRING: ENSP00000332679
CYP2A6ENSP000003011414STRING: ENSP00000301141
DPYDENSP000003592114STRING: ENSP00000359211
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Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006206pyrimidine nucleobase metabolic process TAS--
GO:0009116nucleoside metabolic process NAS12849978
GO:0009166nucleotide catabolic process IEA--
GO:0043097pyrimidine nucleoside salvage TAS--
GO:0044206UMP salvage IEA--

Find genes that share ontologies with UPP2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for UPP2

3 HMDB Compounds for UPP2    About this table
CompoundSynonyms CAS #PubMed Ids
Deoxyuridine1-(2-Deoxy-D-erythro-pentofuranosyl)uracil (see all 12)951-78-0--
Uracil2,4-Dihydroxypyrimidine (see all 8)66-22-8--
Uridine1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (see all 9)58-96-8--

1 DrugBank Compound for UPP2    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Fluorouracil5-Fluorouracil (see all 6)51-21-8enzymesubstrate16720348



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for UPP2 gene (2 alternative transcripts): 
NM_001135098.1  NM_173355.3  

Unigene Cluster for UPP2:

Uridine phosphorylase 2
Hs.128427  [show with all ESTs]
Unigene Representative Sequence: NM_173355
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000605860 ENST00000460456 ENST00000005756(uc002tzp.3) ENST00000489438
ENST00000409859(uc002tzo.3)
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate UPP2 (see all 13):
hsa-miR-323-3p hsa-miR-3163 hsa-miR-668 hsa-miR-3607-3p hsa-miR-550a hsa-miR-448 hsa-miR-516b hsa-miR-944
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  QuantiFast Probe-based Assays in human, mouse, rat UPP2

Additional mRNA sequence: 

AK122743.2 AY225131.1 BC033529.2 

2 DOTS entries:

DT.92031316  DT.99949986 

Selected AceView cDNA sequences (see all 41):

AI792814 AK122743 BX095694 AA923601 AI636024 BC033529 AI822005 AA923603 
AW611995 AA344308 AW242408 NM_173355 BE326905 AW451913 AI244830 AI863615 
AW006901 AI863606 AA995921 AW771260 BF197601 AW772212 BI757073 AY225131 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UPP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTAGAACATT
UPP2 Expression
About this image

UPP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

UPP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.128427

UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045
Tissue specificity: Predominantly expressed in kidney

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QuantiFast Probe-based Assays in human, mouse, rat UPP2
In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for UPP2 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Upp21 , 5 uridine phosphorylase 21, 5 86.12(n)1
87.7(a)1
  2 (33.16 cM)5
766541  NM_029692.21  NP_083968.11 
 585672985 
chicken
(Gallus gallus)
Aves UPP21 uridine phosphorylase 2 68.65(n)
75.83(a)
  424326  XM_422171.4  XP_422171.2 
lizard
(Anolis carolinensis)
Reptilia UPP26
uridine phosphorylase 2
78(a)
1 ↔ 1
GL343379.1(969612-1052365)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20842 Xenopus laevis transcribed sequence with weak similarity more 73.14(n)    BJ067622.1 
zebrafish
(Danio rerio)
Actinopterygii zgc558832 hypothetical protein MGC55883 74.52(n)   393113  BC044525.1 
fruit fly
(Drosophila melanogaster)
Insecta CG63301 CG6330 54.33(n)
52.94(a)
  43240  NM_143258.3  NP_651515.1 
worm
(Caenorhabditis elegans)
Secernentea upp-11 upp-1 52.45(n)
45.73(a)
  176077  NM_066270.6  NP_498671.2 


ENSEMBL Gene Tree for UPP2 (if available)
TreeFam Gene Tree for UPP2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for UPP2 gene
UPP12  
1 SIMAP similar gene for UPP2 using alignment to 1 protein entry:     UPP2_HUMAN:
UPP1

Find genes that share paralogs with UPP2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UPP2 (see all 3014)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1488198241,2
--158849751(+) AGAGAA/GAGAGG 1 -- us2k10--------
rs1931884401,2
C--158849819(+) GGAGGC/TGGAAG 1 -- us2k10--------
rs1840766471,2
--158850086(+) TTATAC/TGTCAT 1 -- us2k10--------
rs1424927321,2
--158850163(+) CCCTCC/TATTAA 1 -- us2k10--------
rs134265021,2
C,F,H--158850342(+) atggcG/Agagca 1 -- us2k116Minor allele frequency- A:0.09NS EA NA WA CSA 1881
rs1509373511,2
--158850383(+) CTACAC/TACTTT 1 -- us2k10--------
rs1888568861,2
C--158850438(+) GGGGGA/GTGGTG 1 -- us2k10--------
rs1168160441,2
C,F--158850550(+) AGAGCC/AAAACC 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs787416981,2
C,F--158850564(+) TCAAAC/ATTTCA 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs778060161,2
--158850572(+) TCAAGC/TTTGCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for UPP2 (158733214 - 158983214 bp, first 250kb of UPP2)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for UPP2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2673444CNV Deletion23128226
esv2659902CNV Deletion23128226
nsv2991CNV Insertion18451855
nsv519147CNV Loss19592680
nsv517458CNV Loss19592680
nsv834433CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for UPP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for UPP2:    
About MalaCards
timothy syndrome

1 disease from the University of Copenhagen DISEASES database for UPP2:
Timothy syndrome

Find genes that share disorders with UPP2           About GenesLikeMe

Genetic Association Database (GAD): UPP2
Human Genome Epidemiology (HuGE) Navigator: UPP2 (2 documents)

Export disorders for UPP2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for UPP2 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with UPP2)
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  1. Identification of a novel human uridine phosphorylase. (PubMed id 12849978)1, 2, 3, 9 Johansson M. (Biochem. Biophys. Res. Commun. 2003)
  2. A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity. (PubMed id 21855639)1, 2 Roosild T.P.... Pizzorno G. (J. Struct. Biol. 2011)
  3. Genome-wide association reveals genetic effects on human AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PubMed id 20932310)1, 4 Han M.R....Wang L.S. (BMC Neurol 2010)
  4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. Allowing for sex differences increases power in a GWAS of multiplex Autism families. (PubMed id 21151189)1 Lu A.T. and Cantor R.M. (Mol. Psychiatry 2012)
  9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  10. Uridine phosphorylase in breast cancer: a new prognostic factor? (PubMed id 16720348)7 Yan R....Cao D. (Front. Biosci. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 151531 HGNC: 23061 AceView: UPP2 Ensembl:ENSG00000007001 euGenes: HUgn151531
ECgene: UPP2 Kegg: 151531 H-InvDB: UPP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UPP2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UPP2 gene:
Search GeneIP for patents involving UPP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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