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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UPP2 Gene

protein-coding   GIFtS: 56
GCID: GC02P158677

Uridine Phosphorylase 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Uridine Phosphorylase 21 2     UPASE22
UrdPase 22 3     Liver-Specific Uridine Phosphorylase2
UPase 22 3     Uridine Phosphorylase-22
UDRPASE22     EC 2.4.2.33
UP22     

External Ids:    HGNC: 230611   Entrez Gene: 1515312   Ensembl: ENSG000000070017   UniProtKB: O950453   

Export aliases for UPP2 gene to outside databases

Previous GC identifers: GC02P158815 GC02P159054 GC02P158559 GC02P150739


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UPP2 Gene: 
UPP2 (uridine phosphorylase 2) is a protein-coding gene. Diseases associated with UPP2 include timothy syndrome, and among its related super-pathways are Fluoropyrimidine Pathway, Pharmacokinetics and Metabolic pathways. GO annotations related to this gene include uridine phosphorylase activity. An important paralog of this gene is UPP1.

UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045
Function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or
deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue
of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and
thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as
substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UPP2 gene promoter:
         HOXA9B   HOXA9   AML1a   FOXF2   Meis-1b   GATA-1   FOXJ2 (long isoform)   FOXJ2   Meis-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUPP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UPP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.1   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q24.2

UPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P158677:  view genomic region     (about GC identifiers)

Start:
158,733,214 bp from pter      End:
158,992,666 bp from pter
Size:
259,453 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045 (See protein sequence)
Recommended Name: Uridine phosphorylase 2  
Size: 317 amino acids; 35527 Da
Sequence caution: Sequence=AAH33529.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for UPP2:
2XRF (3D)        3P0E (3D)        3P0F (3D)    
Secondary accessions: B3KV87
Alternative splicing: 2 isoforms:  O95045-1   O95045-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UPP2: NX_O95045

Explore proteomics data for UPP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95045

  • UPP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UPP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001128570.1  NP_775491.1  

    ENSEMBL proteins: 
     ENSP00000474090   ENSP00000005756   ENSP00000387230  
    Reactome Protein details: O95045
    Human Recombinant Protein Products for UPP2: 
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    Novus Biologicals UPP2 Protein
    Novus Biologicals UPP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UPP2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0045098type III intermediate filament IDA11278417

    UPP2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for UPP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR018016 Nucleoside_phosphorylase_CS
     IPR018017 Nucleoside_phosphorylase
     IPR010059 Uridine_phosphorylase_euk
     IPR000845 Nucleoside_phosphorylase_d

    Graphical View of Domain Structure for InterPro Entry O95045

    ProtoNet protein and cluster: O95045

    1 Blocks protein domain: IPB000845 Purine and other phosphorylases

    UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045
    Similarity: Belongs to the PNP/UDP phosphorylase family


    UPP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UPP2_HUMAN, O95045
    Function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or
    deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue
    of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and
    thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as
    substrates
    Catalytic activity: Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
    Enzyme regulation: A conditional disulfide bridge can form within the protein that dislocates a critical
    phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme

         Enzyme Number (IUBMB): EC 2.4.2.31

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004850uridine phosphorylase activity IDA12849978
         
    UPP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UPP2:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UPP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UPP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UPP2 
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    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate UPP2 (see all 13):
    hsa-miR-323-3p hsa-miR-3163 hsa-miR-668 hsa-miR-3607-3p hsa-miR-550a hsa-miR-448 hsa-miR-516b hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidUPP2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UPP2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fluoropyrimidine Activity
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Pyrimidine metabolism
    Pyrimidine metabolism0.50
    Pyrimidine salvage reactions0.38
    Pyrimidine catabolism0.50
    4pyrimidine ribonucleosides degradation
    pyrimidine ribonucleosides degradation0.67
    pyrimidine deoxyribonucleosides degradation0.67
    5thymine degradation
    superpathway of pyrimidine ribonucleosides degradation0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for UPP2
        Fluoropyrimidine Activity
    pyrimidine ribonucleosides degradation
    pyrimidine deoxyribonucleosides degradation
    superpathway of pyrimidine ribonucleosides degradation

    5        Reactome Pathways for UPP2
        Metabolism of nucleotides
    Metabolism
    Pyrimidine catabolism
    Pyrimidine salvage reactions
    Pyrimidine metabolism

    1 PharmGKB Pathway for UPP2
        Fluoropyrimidine Pathway, Pharmacokinetics

    3         Kegg Pathways  (Kegg details for UPP2):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route):
    step 1/1


    UPP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UPP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/21 Interacting proteins for UPP2 (O950453 ENSP000003872304) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    VIMP086703, ENSP000002242374I2D: score=2 STRING: ENSP00000224237
    CDAENSP000003642124STRING: ENSP00000364212
    DPYDENSP000003592114STRING: ENSP00000359211
    NT5C2ENSP000003394794STRING: ENSP00000339479
    NT5C3AENSP000002422104STRING: ENSP00000242210
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0009116nucleoside metabolic process NAS12849978
    GO:0009166nucleotide catabolic process IEA--
    GO:0043097pyrimidine nucleoside salvage TAS--
    GO:0044206UMP salvage IEA--

    UPP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UPP2

    3 HMDB Compounds for UPP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Deoxyuridine1-(2-Deoxy-D-erythro-pentofuranosyl)uracil (see all 12)951-78-0--
    Uracil2,4-Dihydroxypyrimidine (see all 8)66-22-8--
    Uridine1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (see all 9)58-96-8--

    1 DrugBank Compound for UPP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fluorouracil5-Fluorouracil (see all 6)51-21-8enzymesubstrate16720348

    Search CenterWatch for drugs/clinical trials and news about UPP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UPP2 gene (2 alternative transcripts): 
    NM_001135098.1  NM_173355.3  

    Unigene Cluster for UPP2:

    Uridine phosphorylase 2
    Hs.128427  [show with all ESTs]
    Unigene Representative Sequence: NM_173355
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000605860 ENST00000460456 ENST00000005756(uc002tzp.3) ENST00000489438
    ENST00000409859(uc002tzo.3)
    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate UPP2 (see all 13):
    hsa-miR-323-3p hsa-miR-3163 hsa-miR-668 hsa-miR-3607-3p hsa-miR-550a hsa-miR-448 hsa-miR-516b hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidUPP2 3' UTR sequence
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    Additional mRNA sequence: 

    AK122743.2 AY225131.1 BC033529.2 

    2 DOTS entries:

    DT.92031316  DT.99949986 

    24/41 AceView cDNA sequences (see all 41):

    AI792814 NM_173355 AI822005 BC033529 BE326905 AI863615 AI244830 AA344308 
    AW242408 AW451913 BX095694 AW611995 AI636024 AA923601 AK122743 AA923603 
    BF197601 BE463550 BI757073 AW771260 AW772212 AA975176 AW006901 AW070369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UPP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGAACATT
    UPP2 Expression
    About this image


    See UPP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UPP2

    SOURCE GeneReport for Unigene cluster: Hs.128427

    UniProtKB/Swiss-Prot: UPP2_HUMAN, O95045
    Tissue specificity: Predominantly expressed in kidney

        SABiosciences Custom PCR Arrays for UPP2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UPP2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Upp21 , 5 uridine phosphorylase 21, 5 86.12(n)1
    87.7(a)1
      2 (33.16 cM)5
    766541  NM_029692.21  NP_083968.11 
     585672985 
    chicken
    (Gallus gallus)
    Aves UPP21 uridine phosphorylase 2 68.65(n)
    75.83(a)
      424326  XM_422171.3  XP_422171.2 
    lizard
    (Anolis carolinensis)
    Reptilia UPP26
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343379.1(969612-1052365)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.20842 Xenopus laevis transcribed sequence with weak similarity more 73.14(n)    BJ067622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558832 hypothetical protein MGC55883 74.52(n)   393113  BC044525.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63301 CG6330 52.4(n)
    49.52(a)
      43240  NM_143258.2  NP_651515.1 
    worm
    (Caenorhabditis elegans)
    Secernentea upp-16
    Protein UPP-1
    45(a)
    1 → many
    III(7641034-7643103)


    ENSEMBL Gene Tree for UPP2 (if available)
    TreeFam Gene Tree for UPP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UPP2 gene
    UPP12  
    1 SIMAP similar gene for UPP2 using alignment to 1 protein entry:     UPP2_HUMAN:
    UPP1

    UPP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3014 SNPs in UPP2 are shown (see all 3014)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488198241,2
    --158849751(+) AGAGAA/GAGAGG 1 -- us2k10--------
    rs1931884401,2
    C--158849819(+) GGAGGC/TGGAAG 1 -- us2k10--------
    rs1840766471,2
    --158850086(+) TTATAC/TGTCAT 1 -- us2k10--------
    rs1424927321,2
    --158850163(+) CCCTCC/TATTAA 1 -- us2k10--------
    rs134265021,2
    C,F,H--158850342(+) atggcG/Agagca 1 -- us2k116Minor allele frequency- A:0.09NS EA NA WA CSA 1881
    rs1509373511,2
    --158850383(+) CTACAC/TACTTT 1 -- us2k10--------
    rs1888568861,2
    C--158850438(+) GGGGGA/GTGGTG 1 -- us2k10--------
    rs1168160441,2
    C,F--158850550(+) AGAGCC/AAAACC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs787416981,2
    C,F--158850564(+) TCAAAC/ATTTCA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs778060161,2
    --158850572(+) TCAAGC/TTTGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UPP2 (158733214 - 158983214 bp, first 250kb of UPP2)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for UPP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673444CNV Deletion23128226
    esv2659902CNV Deletion23128226
    nsv2991CNV Insertion18451855
    nsv519147CNV Loss19592680
    nsv517458CNV Loss19592680
    nsv834433CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for UPP2:    About MalaCards
    timothy syndrome    

    1 disease from the University of Copenhagen DISEASES database for UPP2:
    Timothy syndrome

    UPP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UPP2
    Human Genome Epidemiology (HuGE) Navigator: UPP2 (2 documents)

    Export disorders for UPP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UPP2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with UPP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human uridine phosphorylase. (PubMed id 12849978)1, 2, 3, 9 Johansson M. (2003)
    2. A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity. (PubMed id 21855639)1, 2 Roosild T.P.... Pizzorno G. (2011)
    3. Genome-wide association reveals genetic effects on hu man AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PubMed id 20932310)1, 4 Han M.R....Wang L.S. (2010)
    4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (2009)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Allowing for sex differences increases power in a GWAS of multiplex Autism families. (PubMed id 21151189)1 Lu A.T. and Cantor R.M. (2012)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Uridine phosphorylase in breast cancer: a new prognostic factor? (PubMed id 16720348)7 Yan R....Cao D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 151531 HGNC: 23061 AceView: UPP2 Ensembl:ENSG00000007001 euGenes: HUgn151531
    ECgene: UPP2 Kegg: 151531 H-InvDB: UPP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UPP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UPP2 gene:
    Search GeneIP for patents involving UPP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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