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Aliases for UPP2 Gene

Aliases for UPP2 Gene

  • Uridine Phosphorylase 2 2 3
  • UrdPase 2 3 4
  • UPase 2 3 4
  • Liver-Specific Uridine Phosphorylase 3
  • Uridine Phosphorylase-2 3
  • EC 2.4.2.3 4
  • UDRPASE2 3
  • UPASE2 3
  • UP2 3

External Ids for UPP2 Gene

Previous GeneCards Identifiers for UPP2 Gene

  • GC02P158815
  • GC02P159054
  • GC02P158677
  • GC02P158559
  • GC02P150739
  • GC02P158736

Summaries for UPP2 Gene

GeneCards Summary for UPP2 Gene

UPP2 (Uridine Phosphorylase 2) is a Protein Coding gene. Diseases associated with UPP2 include timothy syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include uridine phosphorylase activity. An important paralog of this gene is UPP1.

UniProtKB/Swiss-Prot for UPP2 Gene

  • Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2()-deoxyuridine as substrates

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPP2 Gene

Genomics for UPP2 Gene

Regulatory Elements for UPP2 Gene

Genomic Location for UPP2 Gene

Start:
157,876,702 bp from pter
End:
158,136,154 bp from pter
Size:
259,453 bases
Orientation:
Plus strand

Genomic View for UPP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPP2 Gene

Proteins for UPP2 Gene

  • Protein details for UPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95045-UPP2_HUMAN
    Recommended name:
    Uridine phosphorylase 2
    Protein Accession:
    O95045
    Secondary Accessions:
    • B3KV87

    Protein attributes for UPP2 Gene

    Size:
    317 amino acids
    Molecular mass:
    35527 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33529.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UPP2 Gene

    Alternative splice isoforms for UPP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UPP2 Gene

Proteomics data for UPP2 Gene at MOPED

Post-translational modifications for UPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UPP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UPP2 Gene

Domains for UPP2 Gene

Suggested Antigen Peptide Sequences for UPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95045

UniProtKB/Swiss-Prot:

UPP2_HUMAN :
  • O95045
Family:
  • Belongs to the PNP/UDP phosphorylase family.
genes like me logo Genes that share domains with UPP2: view

No data available for Gene Families for UPP2 Gene

Function for UPP2 Gene

Molecular function for UPP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: A conditional disulfide bridge can form within the protein that dislocates a critical phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme.
UniProtKB/Swiss-Prot Function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2()-deoxyuridine as substrates

Enzyme Numbers (IUBMB) for UPP2 Gene

Gene Ontology (GO) - Molecular Function for UPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004850 uridine phosphorylase activity IDA 12849978
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UPP2: view

Phenotypes for UPP2 Gene

GenomeRNAi human phenotypes for UPP2:
genes like me logo Genes that share phenotypes with UPP2: view

Animal Model Products

CRISPR Products

miRNA for UPP2 Gene

miRTarBase miRNAs that target UPP2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UPP2 Gene

Localization for UPP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPP2 Gene COMPARTMENTS Subcellular localization image for UPP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 2
nucleus 2
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0045098 type III intermediate filament IDA 11278417
genes like me logo Genes that share ontologies with UPP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UPP2 Gene

Pathways for UPP2 Gene

genes like me logo Genes that share pathways with UPP2: view

UniProtKB/Swiss-Prot O95045-UPP2_HUMAN

  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1

Interacting Proteins for UPP2 Gene

Selected Interacting proteins: O95045-UPP2_HUMAN for UPP2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for UPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0009116 nucleoside metabolic process NAS 12849978
GO:0009166 nucleotide catabolic process IEA --
GO:0043097 pyrimidine nucleoside salvage TAS --
GO:0044206 UMP salvage IEA --
genes like me logo Genes that share ontologies with UPP2: view

Compounds for UPP2 Gene

(3) HMDB Compounds for UPP2 Gene

Compound Synonyms Cas Number PubMed IDs
Deoxyuridine
  • 1-(2-Deoxy-D-erythro-pentofuranosyl)uracil
951-78-0
Uracil
  • 2,4-Dihydroxypyrimidine
66-22-8
Uridine
  • 1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
58-96-8

(1) Drugbank Compounds for UPP2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Fluorouracil
  • 5-Fluorouracil
51-21-8 enzyme substrate
genes like me logo Genes that share compounds with UPP2: view

Transcripts for UPP2 Gene

Unigene Clusters for UPP2 Gene

Uridine phosphorylase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UPP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPP2 Gene

No ASD Table

Relevant External Links for UPP2 Gene

GeneLoc Exon Structure for
UPP2
ECgene alternative splicing isoforms for
UPP2

Expression for UPP2 Gene

mRNA expression in normal human tissues for UPP2 Gene

mRNA differential expression in normal tissues according to GTEx for UPP2 Gene

This gene is overexpressed in Kidney - Cortex (11.8) and Liver (8.1).

SOURCE GeneReport for Unigene cluster for UPP2 Gene Hs.128427

mRNA Expression by UniProt/SwissProt for UPP2 Gene

O95045-UPP2_HUMAN
Tissue specificity: Predominantly expressed in kidney.
genes like me logo Genes that share expressions with UPP2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for UPP2 Gene

Orthologs for UPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UPP2 35
  • 99.16 (n)
  • 98.74 (a)
UPP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UPP2 35
  • 88.96 (n)
  • 89.27 (a)
UPP2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Upp2 35
  • 86.12 (n)
  • 87.7 (a)
Upp2 16
Upp2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UPP2 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upp2 35
  • 84.56 (n)
  • 86.26 (a)
chicken
(Gallus gallus)
Aves UPP2 35
  • 68.65 (n)
  • 75.83 (a)
UPP2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UPP2 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2084 35
tropical clawed frog
(Silurana tropicalis)
Amphibia upp2 35
  • 68.68 (n)
  • 72.06 (a)
zebrafish
(Danio rerio)
Actinopterygii upp2 35
  • 67.11 (n)
  • 67.11 (a)
upp2 36
  • 65 (a)
OneToOne
zgc55883 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000188 35
  • 55.29 (n)
  • 54.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17224 36
  • 41 (a)
ManyToMany
CG3788 36
  • 36 (a)
ManyToMany
CG6330 35
  • 54.33 (n)
  • 52.94 (a)
CG6330 36
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea upp-1 35
  • 52.45 (n)
  • 45.73 (a)
upp-1 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
ManyToMany
CSA.9473 36
  • 37 (a)
ManyToMany
CSA.9869 36
  • 40 (a)
ManyToMany
Species with no ortholog for UPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UPP2 Gene

ENSEMBL:
Gene Tree for UPP2 (if available)
TreeFam:
Gene Tree for UPP2 (if available)

Paralogs for UPP2 Gene

Paralogs for UPP2 Gene

Selected SIMAP similar genes for UPP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UPP2: view

Variants for UPP2 Gene

Sequence variations from dbSNP and Humsavar for UPP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs714566 -- 158,001,253(-) CTCCT(C/T)AATAA intron-variant
rs725448 -- 158,001,424(-) TCTCC(G/T)TGGGC intron-variant
rs740551 -- 158,006,722(-) AAGAC(A/G)CCCAC intron-variant
rs740552 -- 158,006,678(-) AGTGA(C/G/T)TCTTG intron-variant
rs740553 -- 158,005,041(+) TATCA(A/C)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UPP2 Gene

Variant ID Type Subtype PubMed ID
nsv834433 CNV Gain 17160897
nsv2991 CNV Insertion 18451855
esv2659902 CNV Deletion 23128226
nsv517458 CNV Loss 19592680
nsv519147 CNV Loss 19592680
esv2673444 CNV Deletion 23128226

Relevant External Links for UPP2 Gene

HapMap Linkage Disequilibrium report
UPP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPP2 Gene

Disorders for UPP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UPP2 Gene including...

Search for UPP2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UPP2 Gene

Relevant External Links for UPP2

Genetic Association Database (GAD)
UPP2
Human Genome Epidemiology (HuGE) Navigator
UPP2
genes like me logo Genes that share disorders with UPP2: view

No data available for UniProtKB/Swiss-Prot for UPP2 Gene

Publications for UPP2 Gene

  1. Identification of a novel human uridine phosphorylase. (PMID: 12849978) Johansson M. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 48

Products for UPP2 Gene

Sources for UPP2 Gene

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