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Aliases for UPP2 Gene

Aliases for UPP2 Gene

  • Uridine Phosphorylase 2 2 3 5
  • UrdPase 2 3 4
  • UPase 2 3 4
  • Liver-Specific Uridine Phosphorylase 3
  • Uridine Phosphorylase-2 3
  • EC 2.4.2.3 4
  • UDRPASE2 3
  • UPASE2 3
  • UP2 3

External Ids for UPP2 Gene

Previous GeneCards Identifiers for UPP2 Gene

  • GC02P158815
  • GC02P159054
  • GC02P158677
  • GC02P158559
  • GC02P150739
  • GC02P158736

Summaries for UPP2 Gene

GeneCards Summary for UPP2 Gene

UPP2 (Uridine Phosphorylase 2) is a Protein Coding gene. Among its related pathways are Purine metabolism and pyrimidine deoxyribonucleosides degradation. GO annotations related to this gene include uridine phosphorylase activity. An important paralog of this gene is UPP1.

UniProtKB/Swiss-Prot for UPP2 Gene

  • Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2()-deoxyuridine as substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPP2 Gene

Genomics for UPP2 Gene

Regulatory Elements for UPP2 Gene

Enhancers for UPP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UPP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UPP2 Gene

Chromosome:
2
Start:
157,876,702 bp from pter
End:
158,136,154 bp from pter
Size:
259,453 bases
Orientation:
Plus strand

Genomic View for UPP2 Gene

Genes around UPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPP2 Gene

Proteins for UPP2 Gene

  • Protein details for UPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95045-UPP2_HUMAN
    Recommended name:
    Uridine phosphorylase 2
    Protein Accession:
    O95045
    Secondary Accessions:
    • B3KV87

    Protein attributes for UPP2 Gene

    Size:
    317 amino acids
    Molecular mass:
    35527 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33529.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UPP2 Gene

    Alternative splice isoforms for UPP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UPP2 Gene

Proteomics data for UPP2 Gene at MOPED

Post-translational modifications for UPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UPP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for UPP2

No data available for DME Specific Peptides for UPP2 Gene

Domains & Families for UPP2 Gene

Suggested Antigen Peptide Sequences for UPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95045

UniProtKB/Swiss-Prot:

UPP2_HUMAN :
  • Belongs to the PNP/UDP phosphorylase family.
Family:
  • Belongs to the PNP/UDP phosphorylase family.
genes like me logo Genes that share domains with UPP2: view

No data available for Gene Families for UPP2 Gene

Function for UPP2 Gene

Molecular function for UPP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
A conditional disulfide bridge can form within the protein that dislocates a critical phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme.
UniProtKB/Swiss-Prot Function:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2()-deoxyuridine as substrates.

Enzyme Numbers (IUBMB) for UPP2 Gene

Gene Ontology (GO) - Molecular Function for UPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004850 uridine phosphorylase activity IEA,IDA 12849978
genes like me logo Genes that share ontologies with UPP2: view

Phenotypes for UPP2 Gene

genes like me logo Genes that share phenotypes with UPP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UPP2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UPP2 Gene

Localization for UPP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPP2 Gene COMPARTMENTS Subcellular localization image for UPP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 2
golgi apparatus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UPP2 Gene

Pathways & Interactions for UPP2 Gene

genes like me logo Genes that share pathways with UPP2: view

UniProtKB/Swiss-Prot O95045-UPP2_HUMAN

  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Interacting Proteins for UPP2 Gene

Selected Interacting proteins: O95045-UPP2_HUMAN for UPP2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for UPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009166 nucleotide catabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0046135 pyrimidine nucleoside catabolic process TAS --
GO:0055086 nucleobase-containing small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with UPP2: view

No data available for SIGNOR curated interactions for UPP2 Gene

Drugs & Compounds for UPP2 Gene

(6) Drugs for UPP2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluorouracil Approved Pharma Enzyme, substrate RNA processing inhibitor and thymidylate synthase inhibitor 1697
5-Fluorouridine Experimental Pharma 0
Ribose-1-Phosphate Experimental Pharma 0
Uracil Experimental Pharma 0
Uridine Experimental Pharma 0

(1) Additional Compounds for UPP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UPP2: view

Transcripts for UPP2 Gene

Unigene Clusters for UPP2 Gene

Uridine phosphorylase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UPP2 Gene

No ASD Table

Relevant External Links for UPP2 Gene

GeneLoc Exon Structure for
UPP2
ECgene alternative splicing isoforms for
UPP2

Expression for UPP2 Gene

mRNA expression in normal human tissues for UPP2 Gene

mRNA differential expression in normal tissues according to GTEx for UPP2 Gene

This gene is overexpressed in Kidney - Cortex (x11.8) and Liver (x8.1).

SOURCE GeneReport for Unigene cluster for UPP2 Gene Hs.128427

mRNA Expression by UniProt/SwissProt for UPP2 Gene

O95045-UPP2_HUMAN
Tissue specificity: Predominantly expressed in kidney.
genes like me logo Genes that share expression patterns with UPP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for UPP2 Gene

Orthologs for UPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UPP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UPP2 35
  • 88.96 (n)
  • 89.27 (a)
UPP2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Upp2 35
  • 86.12 (n)
  • 87.7 (a)
Upp2 16
Upp2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UPP2 35
  • 99.16 (n)
  • 98.74 (a)
UPP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upp2 35
  • 84.56 (n)
  • 86.26 (a)
oppossum
(Monodelphis domestica)
Mammalia UPP2 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves UPP2 35
  • 68.65 (n)
  • 75.83 (a)
UPP2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UPP2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia upp2 35
  • 68.68 (n)
  • 72.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2084 35
zebrafish
(Danio rerio)
Actinopterygii upp2 35
  • 67.11 (n)
  • 67.11 (a)
zgc55883 35
upp2 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000188 35
  • 55.29 (n)
  • 54.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6330 35
  • 54.33 (n)
  • 52.94 (a)
CG17224 36
  • 41 (a)
ManyToMany
CG3788 36
  • 36 (a)
ManyToMany
CG6330 36
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea upp-1 35
  • 52.45 (n)
  • 45.73 (a)
upp-1 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
ManyToMany
CSA.9473 36
  • 37 (a)
ManyToMany
CSA.9869 36
  • 40 (a)
ManyToMany
Species with no ortholog for UPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UPP2 Gene

ENSEMBL:
Gene Tree for UPP2 (if available)
TreeFam:
Gene Tree for UPP2 (if available)

Paralogs for UPP2 Gene

Paralogs for UPP2 Gene

(1) SIMAP similar genes for UPP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UPP2: view

Variants for UPP2 Gene

Sequence variations from dbSNP and Humsavar for UPP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6710480 - 158,102,093(+) AATAG(G/T)TCCAT nc-transcript-variant, reference, missense
rs7561584 - 158,115,152(+) TGTTT(A/C)TGCAC nc-transcript-variant, reference, missense
rs714566 -- 158,001,253(-) CTCCT(C/T)AATAA intron-variant
rs725448 -- 158,001,424(-) TCTCC(G/T)TGGGC intron-variant
rs740551 -- 158,006,722(-) AAGAC(A/G)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UPP2 Gene

Variant ID Type Subtype PubMed ID
nsv834433 CNV Gain 17160897
nsv2991 CNV Insertion 18451855
esv2659902 CNV Deletion 23128226
nsv517458 CNV Loss 19592680
nsv519147 CNV Loss 19592680
esv2673444 CNV Deletion 23128226

Variation tolerance for UPP2 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UPP2 Gene

Disorders for UPP2 Gene

Relevant External Links for UPP2

Genetic Association Database (GAD)
UPP2
Human Genome Epidemiology (HuGE) Navigator
UPP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UPP2

No disorders were found for UPP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UPP2 Gene

Publications for UPP2 Gene

  1. Identification of a novel human uridine phosphorylase. (PMID: 12849978) Johansson M. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. Uridine phosphorylase in breast cancer: a new prognostic factor? (PMID: 16720348) Yan R. … Cao D. (Front. Biosci. 2006) 25 26
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Allowing for sex differences increases power in a GWAS of multiplex Autism families. (PMID: 21151189) Lu A.T. … Cantor R.M. (Mol. Psychiatry 2012) 3

Products for UPP2 Gene

Sources for UPP2 Gene

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