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Aliases for UPP1 Gene

Aliases for UPP1 Gene

  • Uridine Phosphorylase 1 2 3 5
  • UrdPase 1 3 4
  • UPase 1 3 4
  • UP 3 4
  • Uridine Phosphorylase 2
  • EC 2.4.2.3 4
  • UDRPASE 3
  • UPASE 3
  • UPP 3

External Ids for UPP1 Gene

Previous HGNC Symbols for UPP1 Gene

  • UP

Previous GeneCards Identifiers for UPP1 Gene

  • GC07P047835
  • GC07P047869
  • GC07P047902
  • GC07P048094
  • GC07P048013

Summaries for UPP1 Gene

Entrez Gene Summary for UPP1 Gene

  • The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]

GeneCards Summary for UPP1 Gene

UPP1 (Uridine Phosphorylase 1) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (REACTOME) and Purine metabolism. GO annotations related to this gene include transferase activity, transferring pentosyl groups and uridine phosphorylase activity. An important paralog of this gene is UPP2.

UniProtKB/Swiss-Prot for UPP1 Gene

  • Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Gene Wiki entry for UPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPP1 Gene

Genomics for UPP1 Gene

Regulatory Elements for UPP1 Gene

Enhancers for UPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around UPP1 on UCSC Golden Path with GeneCards custom track

Promoters for UPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for UPP1 Gene

Chromosome:
7
Start:
48,088,603 bp from pter
End:
48,108,733 bp from pter
Size:
20,131 bases
Orientation:
Plus strand

Genomic View for UPP1 Gene

Genes around UPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPP1 Gene

Proteins for UPP1 Gene

  • Protein details for UPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16831-UPP1_HUMAN
    Recommended name:
    Uridine phosphorylase 1
    Protein Accession:
    Q16831
    Secondary Accessions:
    • D3DVM4
    • Q15362

    Protein attributes for UPP1 Gene

    Size:
    310 amino acids
    Molecular mass:
    33934 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for UPP1 Gene

    Alternative splice isoforms for UPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UPP1 Gene

Post-translational modifications for UPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for UPP1 Gene

Domains & Families for UPP1 Gene

Suggested Antigen Peptide Sequences for UPP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16831

UniProtKB/Swiss-Prot:

UPP1_HUMAN :
  • Belongs to the PNP/UDP phosphorylase family.
Family:
  • Belongs to the PNP/UDP phosphorylase family.
genes like me logo Genes that share domains with UPP1: view

No data available for Gene Families for UPP1 Gene

Function for UPP1 Gene

Molecular function for UPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
UniProtKB/Swiss-Prot Induction:
By vitamin D3 and a mixture of inflammatory cytokines: TNF, IL1/interleukin-1 and IFNG/IFN-gamma.

Enzyme Numbers (IUBMB) for UPP1 Gene

Gene Ontology (GO) - Molecular Function for UPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004850 uridine phosphorylase activity EXP 7488099
genes like me logo Genes that share ontologies with UPP1: view
genes like me logo Genes that share phenotypes with UPP1: view

Animal Models for UPP1 Gene

MGI Knock Outs for UPP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for UPP1

CRISPR Products

miRNA for UPP1 Gene

miRTarBase miRNAs that target UPP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UPP1 Gene

Localization for UPP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPP1 Gene COMPARTMENTS Subcellular localization image for UPP1 gene
Compartment Confidence
cytosol 5
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UPP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UPP1 Gene

Pathways & Interactions for UPP1 Gene

genes like me logo Genes that share pathways with UPP1: view

UniProtKB/Swiss-Prot Q16831-UPP1_HUMAN

  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Gene Ontology (GO) - Biological Process for UPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 7488099
GO:0006218 uridine catabolic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IEA --
GO:0009166 nucleotide catabolic process IEA --
GO:0042149 cellular response to glucose starvation IEA --
genes like me logo Genes that share ontologies with UPP1: view

No data available for SIGNOR curated interactions for UPP1 Gene

Drugs & Compounds for UPP1 Gene

(10) Drugs for UPP1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluorouracil Approved Pharma Enzyme, substrate RNA processing inhibitor and thymidylate synthase inhibitor 1728
Phosphoric acid Approved Pharma 0
Uridine Experimental Pharma 0
1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE Experimental Pharma Target 0
5-Fluorouridine Experimental Pharma 0

(7) Additional Compounds for UPP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ribose 1-phosphate
  • 1-O-Phosphono-D-ribofuranose
  • a-D-Ribofuranose 1-(dihydrogen phosphate)
  • a-D-Ribose 1-phosphate
  • alpha-D-Ribofuranose 1-(dihydrogen phosphate)
  • alpha-D-Ribofuranose 1-phosphate
14075-00-4
genes like me logo Genes that share compounds with UPP1: view

Transcripts for UPP1 Gene

Unigene Clusters for UPP1 Gene

Uridine phosphorylase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a ·
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - - - - - -
SP12:
SP13: - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - -
SP18: - - - - - - -
SP19:
SP20: - - - -

ExUns: 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c · 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for UPP1 Gene

GeneLoc Exon Structure for
UPP1
ECgene alternative splicing isoforms for
UPP1

Expression for UPP1 Gene

mRNA expression in normal human tissues for UPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPP1 Gene

This gene is overexpressed in Whole Blood (x16.1) and Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for UPP1 Gene

This gene is overexpressed in Lung (11.7), CD8 Tcells (9.5), NK cells (8.9), Breast (8.0), Lymph node (6.5), and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UPP1 Gene



Protein tissue co-expression partners for UPP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UPP1 Gene:

UPP1

SOURCE GeneReport for Unigene cluster for UPP1 Gene:

Hs.488240
genes like me logo Genes that share expression patterns with UPP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UPP1 Gene

Orthologs for UPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UPP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UPP1 34
  • 81.88 (n)
  • 80.58 (a)
UPP1 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UPP1 34
  • 76.08 (n)
  • 70.13 (a)
-- 35
  • 70 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Upp1 34
  • 82.04 (n)
  • 79.35 (a)
Upp1 16
Upp1 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UPP1 34
  • 99.78 (n)
  • 100 (a)
UPP1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upp1 34
  • 81.94 (n)
  • 80.65 (a)
oppossum
(Monodelphis domestica)
Mammalia UPP1 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UPP1 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves UPP1 34
  • 70.23 (n)
  • 72.82 (a)
UPP1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9081 34
upp1 34
  • 69.75 (n)
  • 72.6 (a)
zebrafish
(Danio rerio)
Actinopterygii upp1 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3788 34
  • 54.2 (n)
  • 49.3 (a)
CG17224 35
  • 43 (a)
ManyToMany
CG3788 35
  • 38 (a)
ManyToMany
CG6330 35
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea upp-1 35
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
ManyToMany
CSA.9473 35
  • 35 (a)
ManyToMany
CSA.9869 35
  • 37 (a)
ManyToMany
Species where no ortholog for UPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UPP1 Gene

ENSEMBL:
Gene Tree for UPP1 (if available)
TreeFam:
Gene Tree for UPP1 (if available)

Paralogs for UPP1 Gene

Paralogs for UPP1 Gene

(1) SIMAP similar genes for UPP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with UPP1: view

Variants for UPP1 Gene

Sequence variations from dbSNP and Humsavar for UPP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2230761 -- 48,107,042(+) ACCAC(A/G)GTGGT nc-transcript-variant, reference, synonymous-codon
rs2230762 -- 48,108,271(+) TCAGC(A/G)GCCCT nc-transcript-variant, reference, missense
rs2230763 -- 48,108,291(+) CTCAG(C/T)GAGTA nc-transcript-variant, reference, synonymous-codon
rs7793905 -- 48,087,597(+) gtgcc(C/T)caagc upstream-variant-2KB
rs7794100 -- 48,087,848(+) ctgtg(A/C)ccggc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UPP1 Gene

Variant ID Type Subtype PubMed ID
esv2734369 CNV deletion 23290073
esv997355 CNV deletion 20482838
nsv1027414 CNV loss 25217958
nsv1132052 CNV deletion 24896259
nsv464442 CNV gain 19166990
nsv470221 CNV gain 18288195
nsv606893 CNV gain 21841781

Variation tolerance for UPP1 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPP1 Gene

Disorders for UPP1 Gene

Relevant External Links for UPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UPP1

No disorders were found for UPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UPP1 Gene

Publications for UPP1 Gene

  1. Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. (PMID: 19291308) Roosild T.P. … Pizzorno G. (BMC Struct. Biol. 2009) 3 4 22 65
  2. Expression of uridine and thymidine phosphorylase genes in human breast carcinoma. (PMID: 11807789) Kanzaki A. … Uchida T. (Int. J. Cancer 2002) 2 3 22 65
  3. Active site conformational dynamics in human uridine phosphorylase 1. (PMID: 20856879) Roosild T.P. … Castronovo S. (PLoS ONE 2010) 3 4 65
  4. Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1. (PMID: 19714313) Im Y.S. … Choi J.K. (Mol. Cells 2009) 3 22 65
  5. The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells. (PMID: 16798057) Temmink O.H. … Peters G.J. (Int. J. Biochem. Cell Biol. 2006) 3 22 65

Products for UPP1 Gene

Sources for UPP1 Gene

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