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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UPP1 Gene

protein-coding GIFtS: 60
GCID: GC07P048094

uridine phosphorylase 1

(Previous name: uridine phosphorylase )
(Previous symbol: UP)

Explore 13 diseases affiliated with
UPP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Uridine Phosphorylase 1¹ ²		UrdPase 1² ³
UP¹ ² ³ ⁵		UPase 1² ³
UDRPASE¹ ²		Uridine Phosphorylase¹
UPASE¹ ²		EC 2.4.2.3³
UPP¹ ²

External Ids:	HGNC: 12576¹	Entrez Gene: 7378²	Ensembl: ENSG00000183696⁷	OMIM: 191730⁵	UniProtKB: Q16831³

Export aliases for UPP1 gene to outside databases

Previous GC identifers: GC07P047835 GC07P047869 GC07P047902 GC07P048013

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UPP1:

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine

phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine

and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate.

Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be

incorporated into RNA or DNA (Watanabe and Uchida, 1995 (PubMed 7488099)).(supplied by OMIM, Aug 2009)

UniProtKB/Swiss-Prot: UPP1_HUMAN, Q16831

Function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or

deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of

pyrimidine bases for nucleotide synthesis

Gene Wiki entry for UPP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UPP1 gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): UPP1 promoter sequence

Search SABiosciences Chromatin IP Primers for UPP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UPP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12.3 Ensembl cytogenetic band: 7p12.3 HGNC cytogenetic band: 7p12.3

UPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPP1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P048094: view genomic region (about GC identifiers)

Start:	48,128,225 bp from pter	End:	48,148,330 bp from pter
Size:	20,106 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 48,168,224-48,188,201

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UPP1_HUMAN, Q16831 (See protein sequence)

Recommended Name: Uridine phosphorylase 1

Size: 310 amino acids; 33934 Da

Subunit: Homodimer

3 PDB 3D structures from and Proteopedia for UPP1:

3EUE (3D)

3EUF (3D)

3NBQ (3D)

Secondary accessions: D3DVM4 Q15362

Alternative splicing: 2 isoforms: Q16831-1 Q16831-2 (Inactive)

Explore the universe of human proteins at neXtProt for UPP1: NX_Q16831

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16831

UPP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_003355.1 NP_853628.1

ENSEMBL proteins:

ENSP00000405209 ENSP00000330032 ENSP00000387607 ENSP00000408899 ENSP00000414963

ENSP00000378931 ENSP00000378927 ENSP00000390118 ENSP00000396820 ENSP00000413611

ENSP00000342878 ENSP00000406224

Reactome Protein details: Q16831
Human Recombinant Protein Products for UPP1:

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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for UPP1
	Uscn Proteins for UPP1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

UPP1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for UPP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UPP1 for domains About GeneDecksing

4 InterPro domains/families:

IPR018016 Nucleoside_phosphorylase_CS

IPR018017 Nucleoside_phosphorylase

IPR010059 Uridine_phosphorylase_euk

IPR000845 Nucleoside_phosphorylase_d

Graphical View of Domain Structure for InterPro Entry Q16831

ProtoNet protein and cluster: Q16831

1 Blocks protein family: IPB000845 Purine and other phosphorylases

UniProtKB/Swiss-Prot: UPP1_HUMAN, Q16831

Similarity: Belongs to the PNP/UDP phosphorylase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: UPP1_HUMAN, Q16831

Function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or

deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of

pyrimidine bases for nucleotide synthesis

Catalytic activity: Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate

Induction: By vitamin D3 and a mixture of inflammatory cytokines: TNF, IL1/interleukin-1 and IFNG/IFN-gamma

Enzyme Number (IUBMB): EC 2.4.2.3¹

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004850	uridine phosphorylase activity	IEA	--

UPP1 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Upp1):

behavior/neurological	cellular	homeostasis/metabolism	immune system	nervous system
renal/urinary system	skeleton

UPP1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for UPP1: Upp1^tm1Gp Upp1^tm1Akiy

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UPP1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Pyrimidine metabolism

	Pyrimidine metabolism	1.00			Pyrimidine salvage reactions	0.38
	Pyrimidine catabolism	0.50

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Fluoropyrimidine Activity

Fluoropyrimidine Activity

1.00

Fluoropyrimidine Pathway, Pharmacokinetics

0.73

pyrimidine ribonucleotides interconversion

salvage pathways of pyrimidine ribonucleotides

0.45

Purine metabolism

Metabolism of nucleotides

0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for UPP1

	Fluoropyrimidine Activity
	salvage pathways of pyrimidine ribonucleotides

5 Reactome Pathways for UPP1

	Metabolism of nucleotides
	Metabolism
	Pyrimidine catabolism
	Pyrimidine salvage reactions
	Pyrimidine metabolism

1 PharmGKB Pathway for UPP1

Fluoropyrimidine Pathway, Pharmacokinetics

3 Kegg Pathways (Kegg details for UPP1):

	Pyrimidine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways

UniProtKB/Swiss-Prot: UPP1_HUMAN, Q16831

Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step

1/1

UPP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UPP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/20 Interacting proteins for UPP1 (Q16831³ ENSP00000330032⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VIM	P08670³, ENSP00000224237⁴	I2D: score=3 STRING: ENSP00000224237
CDA	ENSP00000364212⁴	STRING: ENSP00000364212
CYP2A6	ENSP00000301141⁴	STRING: ENSP00000301141
DPYD	ENSP00000359211⁴	STRING: ENSP00000359211
NT5C3	ENSP00000242210⁴	STRING: ENSP00000242210

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase-containing compound metabolic process	TAS	7488099
GO:0006206	pyrimidine nucleobase metabolic process	TAS	--
GO:0006220	pyrimidine nucleotide metabolic process	--	--
GO:0009116	nucleoside metabolic process	--	--
GO:0009166	nucleotide catabolic process	IEA	--

UPP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UPP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UPP1

3 HMDB Compounds for UPP1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Uracil	2,4-Dihydroxypyrimidine (see all 8)	66-22-8	--
Uridine	1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (see all 9)	58-96-8	--

2 DrugBank Compounds for UPP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE	--	--	target	--	10592235
Fluorouracil	--	51-21-8	enzyme	substrate	16720348

10/11 Novoseek chemical compound relationships for UPP1 gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5-benzylacyclouridine	94.9	4	19291308 (2), 15983408 (1)
ribose 1-phosphate	93	8	15983408 (1), 20226755 (1), 16720348 (1), 15319798 (1) (see all 6)
uridine	92.3	66	15319798 (4), 16798057 (4), 20226755 (3), 17098463 (3) (see all 32)
orotic acid	79	5	18506536 (1), 14562021 (1), 16736497 (1), 10974411 (1) (see all 5)
5'-deoxy-5-fluorouridine	77.6	13	17098463 (3), 19602572 (2), 15319798 (1), 16798057 (1)
5fluorouracil	76.4	41	17214321 (3), 15319798 (3), 16798057 (3), 19304841 (2) (see all 16)
thymidine	71	23	17098463 (2), 16798057 (2), 10969598 (1), 18506536 (1) (see all 20)
deoxyuridine	70.4	2	19028666 (1), 9850074 (1)
pyrimidine	68.7	7	19645718 (2), 15319798 (2), 20226755 (1), 19291308 (1) (see all 5)
thymidylate	68.6	7	10969598 (1), 15911984 (1), 18506536 (1), 16736497 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about UPP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UPP1 gene (2 alternative transcripts):

NM_003364.2 NM_181597.1

Unigene Cluster for UPP1:

Uridine phosphorylase 1

Hs.488240 [show with all ESTs]

Unigene Representative Sequence: BC007348

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000416681 ENST00000331803(uc003tok.3 uc011kch.2 uc003ton.3)

ENST00000432131 ENST00000457596 ENST00000421046(uc011kcg.1) ENST00000395564

ENST00000395560 ENST00000436673 ENST00000444999 ENST00000482015 ENST00000417464

ENST00000495446 ENST00000341253(uc003toj.3 uc003tol.3) ENST00000429491

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Additional cDNA sequence:

AK297863.1 BC001405.1 BC007348.2 BC047030.1 BC053592.1 BT006699.1 X90858.1

20 DOTS entries:

DT.315671 DT.95239905 DT.97855679 DT.65287835 DT.91773929 DT.100031446 DT.100827094 DT.97855676

DT.91773917 DT.121069226 DT.91863645 DT.100827107 DT.121069240 DT.100031445 DT.100827105 DT.100827106

DT.102832027 DT.75162875 DT.91773922 DT.97855677

24/364 AceView cDNA sequences (see all 364):

BM783765 BM839001 BQ008191 BM783808 BU931392 BM759864 BQ016289 BG150284

BU179709 AW196428 BQ017463 BQ051670 AI204318 BU540757 BC053592 CD368032

BM782672 BC047030 BM782390 AA039493 AI656561 AW075781 CB529465 BQ223133

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for UPP1 (see all 20) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	·	2g	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·
SP1:																													-		-																		-		-
SP2:																													-																				-		-
SP3:															-		-												-
SP4:															-		-		-		-		-		-		-		-		-																		-		-
SP5:																													-														-						-		-

ExUns:	10b	·	10c	·	10d	^	11	^	12a	·	12b	·	12c	·	12d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for UPP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UPP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAGCGCCT

About this image

UPP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Lung

Female Gametocytes, Germ Cells

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Cardiomyocyte-like cells (Spontaneous differen...)

See UPP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UPP1

SOURCE GeneReport for Unigene cluster: Hs.488240

SABiosciences Custom PCR Arrays for UPP1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for UPP1 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	UPP1¹	uridine phosphorylase 1	70.23(n) 72.82(a)		420942 XM_419026.2 XP_419026.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.9081²	Transcribed sequence with weak similarity to protein more	82.08(n)		CF784650.1
zebrafish (Danio rerio)	Actinopterygii	upp1⁶	uridine phosphorylase 1	65(a)	1 ↔ 1	16(18255653-18263401)
fruit fly (Drosophila melanogaster)	Insecta	CG3788¹	CG3788	53.62(n) 47.83(a)		37644 NM_001202062.1 NP_001188991.1
worm (Caenorhabditis elegans)	Secernentea	upp-1¹	Protein UPP-1	51.28(n) 47.25(a)		176077 NM_066270.5 NP_498671.2

ENSEMBL Gene Tree for UPP1 (if available)
TreeFam Gene Tree for UPP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for UPP1 gene

UPP2²

1 SIMAP similar gene for UPP1 using alignment to 7 protein entries: UPP1_HUMAN (see all proteins):

UPP2

UPP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80224817^1,2		--	48126388(+)	`GAGCTA/GGGTAA`	1	--	us2k¹		0	--	--	--	--
rs182036561^1,2		--	48126396(+)	`TAAAAC/TGAGGC`	1	--	us2k¹		0	--	--	--	--
rs74670184^1,2	F	--	48126470(+)	`GTTGGC/TAGGTG`	1	--	us2k¹		1		WA	118
rs186017005^1,2		--	48126496(+)	`GGTTAA/CAAAGA`	1	--	us2k¹		0	--	--	--	--
rs190726056^1,2		--	48126614(+)	`TTATTA/CGCTAA`	1	--	us2k¹		0	--	--	--	--
rs150506287^1,2		--	48126677(+)	`ATAAAC/TACCAT`	1	--	us2k¹		0	--	--	--	--
rs139486363^1,2		--	48126686(+)	`ATGGCA/GACATT`	1	--	us2k¹		0	--	--	--	--
rs181158202^1,2		--	48126766(+)	`GTATAC/TGATCA`	2	--	us2k¹		0	--	--	--	--
rs186596418^1,2		--	48126785(+)	`CCATAA/CAAATA`	2	--	us2k¹		0	--	--	--	--
rs144480892^1,2		--	48126794(+)	`TAGCCA/CACCAG`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for UPP1 (48128225 - 48148330 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UPP1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UPP1 for disorders           About GeneDecksing

OMIM gene information: 191730    OMIM disorders: --

13 diseases for UPP1:    About MalaCards

oral squamous cell carcinoma squamous cell carcinoma colon cancer gastric cancer

colorectal cancer breast cancer colon carcinoma hepatocellular carcinoma

carcinoma breast carcinoma osteosarcoma cervicitis

pancreatitis

9 Novoseek disease relationships for UPP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastric cancer	38.2	1	17214321 (1)
colon cancer	33	2	10969598 (1), 17098463 (1)
cancer	27.2	9	11401323 (2), 17949350 (2), 19602572 (1), 20226755 (1) (see all 7)
tumors	17.8	8	17214321 (1), 16720348 (1), 16736497 (1), 15319798 (1) (see all 5)
colorectal cancer	15	2	15911984 (1), 15060742 (1)
solid tumor	14.7	2	17098463 (1), 11807789 (1)
primary tumor	11.1	1	15060742 (1)
breast cancer	0	2	16720348 (2)
metastasis	0	1	15060742 (1)

Export disorders for UPP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for UPP1 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with UPP1)

Utopia: connect your pdf to the dynamic
world of online information

Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. (PubMed id 19291308)^{1, 2, 9} Roosild T.P....Pizzorno G. (2009)
Expression of uridine and thymidine phosphorylase genes in human breast carcinoma. (PubMed id 11807789)^{1, 3, 9} Kanzaki A....Uchida T. (2002)
Active site conformational dynamics in human uridine phosphorylase 1. (PubMed id 20856879)^{1, 2} Roosild T.P. and Castronovo S. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and expression of human uridine phosphorylase. (PubMed id 7488099)^{1, 2} Watanabe S. and Uchida T. (1995)
Assignment of a gene for uridine phosphorylase to chromosome 7. (PubMed id 752472)^{1, 3} Denney R.M....Ruddle F.H. (1978)
Uridine phosphorylase association with vimentin. Intracellular distribution and localization. (PubMed id 11278417)^{1, 9} Russell R.L....Pizzorno G. (2001)
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells. (PubMed id 16798057)^{1, 9} Temmink O.H....Peters G.J. (2006)
Enhanced cytotoxicity of 5-FU by bFGF through up-regu lation of uridine phosphorylase 1. (PubMed id 19714313)^{1, 9} Im Y.S....Choi J.K. (2009)
Uridine phosphorylase in breast cancer: a new prognostic factor? (PubMed id 16720348)^{7, 9} Yan R....Cao D. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7378	HGNC: 12576	AceView: UPP1	Ensembl:ENSG00000183696	euGenes: HUgn7378
ECgene: UPP1	Kegg: 7378	H-InvDB: UPP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UPP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UPP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for UPP1 gene:
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GeneCards and IP:
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