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Aliases for UPP1 Gene

Aliases for UPP1 Gene

  • Uridine Phosphorylase 1 2 3
  • UP 3 4 6
  • UrdPase 1 3 4
  • UPase 1 3 4
  • Uridine Phosphorylase 2
  • EC 2.4.2.3 4
  • UDRPASE 3
  • UPASE 3
  • UPP 3

External Ids for UPP1 Gene

Previous HGNC Symbols for UPP1 Gene

  • UP

Previous GeneCards Identifiers for UPP1 Gene

  • GC07P047835
  • GC07P047869
  • GC07P047902
  • GC07P048094
  • GC07P048013

Summaries for UPP1 Gene

Entrez Gene Summary for UPP1 Gene

  • The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]

GeneCards Summary for UPP1 Gene

UPP1 (Uridine Phosphorylase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include uridine phosphorylase activity. An important paralog of this gene is UPP2.

UniProtKB/Swiss-Prot for UPP1 Gene

  • Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

Gene Wiki entry for UPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPP1 Gene

Genomics for UPP1 Gene

Regulatory Elements for UPP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UPP1 Gene

Start:
48,088,603 bp from pter
End:
48,108,733 bp from pter
Size:
20,131 bases
Orientation:
Plus strand

Genomic View for UPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPP1 Gene

Proteins for UPP1 Gene

  • Protein details for UPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16831-UPP1_HUMAN
    Recommended name:
    Uridine phosphorylase 1
    Protein Accession:
    Q16831
    Secondary Accessions:
    • D3DVM4
    • Q15362

    Protein attributes for UPP1 Gene

    Size:
    310 amino acids
    Molecular mass:
    33934 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for UPP1 Gene

    Alternative splice isoforms for UPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UPP1 Gene

Proteomics data for UPP1 Gene at MOPED

Post-translational modifications for UPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UPP1 Gene

Domains for UPP1 Gene

Suggested Antigen Peptide Sequences for UPP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16831

UniProtKB/Swiss-Prot:

UPP1_HUMAN :
  • Q16831
Family:
  • Belongs to the PNP/UDP phosphorylase family.
genes like me logo Genes that share domains with UPP1: view

No data available for Gene Families for UPP1 Gene

Function for UPP1 Gene

Molecular function for UPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
UniProtKB/Swiss-Prot Function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
UniProtKB/Swiss-Prot Induction: By vitamin D3 and a mixture of inflammatory cytokines: TNF, IL1/interleukin-1 and IFNG/IFN-gamma

Enzyme Numbers (IUBMB) for UPP1 Gene

Gene Ontology (GO) - Molecular Function for UPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004850 uridine phosphorylase activity IEA --
GO:0016763 transferase activity, transferring pentosyl groups --
genes like me logo Genes that share ontologies with UPP1: view
genes like me logo Genes that share phenotypes with UPP1: view

Animal Models for UPP1 Gene

MGI Knock Outs for UPP1:

Animal Model Products

CRISPR Products

miRNA for UPP1 Gene

miRTarBase miRNAs that target UPP1

No data available for Transcription Factor Targeting and HOMER Transcription for UPP1 Gene

Localization for UPP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPP1 Gene COMPARTMENTS Subcellular localization image for UPP1 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UPP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UPP1 Gene

Pathways for UPP1 Gene

genes like me logo Genes that share pathways with UPP1: view

UniProtKB/Swiss-Prot Q16831-UPP1_HUMAN

  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1

Gene Ontology (GO) - Biological Process for UPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 7488099
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006220 pyrimidine nucleotide metabolic process --
GO:0009116 nucleoside metabolic process --
GO:0009166 nucleotide catabolic process IEA --
genes like me logo Genes that share ontologies with UPP1: view

Compounds for UPP1 Gene

(3) HMDB Compounds for UPP1 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Uracil
  • 2,4-Dihydroxypyrimidine
66-22-8
Uridine
  • 1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
58-96-8

(2) Drugbank Compounds for UPP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE
target
Fluorouracil
  • 5-Fluorouracil
51-21-8 enzyme substrate

(11) Novoseek inferred chemical compound relationships for UPP1 Gene

Compound -log(P) Hits PubMed IDs
5-benzylacyclouridine 94.9 3
ribose 1-phosphate 93 6
uridine 92.3 50
orotic acid 79 5
5-deoxy-5-fluorouridine 77.6 7
genes like me logo Genes that share compounds with UPP1: view

Transcripts for UPP1 Gene

Unigene Clusters for UPP1 Gene

Uridine phosphorylase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UPP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a ·
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - - - - - -
SP12:
SP13: - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - -
SP18: - - - - - - -
SP19:
SP20: - - - -

ExUns: 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c · 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for UPP1 Gene

GeneLoc Exon Structure for
UPP1
ECgene alternative splicing isoforms for
UPP1

Expression for UPP1 Gene

mRNA expression in normal human tissues for UPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPP1 Gene

This gene is overexpressed in Whole Blood (16.1) and Esophagus - Mucosa (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UPP1 Gene

SOURCE GeneReport for Unigene cluster for UPP1 Gene Hs.488240

genes like me logo Genes that share expressions with UPP1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UPP1 Gene

Orthologs for UPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UPP1 35
  • 99.78 (n)
  • 100 (a)
UPP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UPP1 35
  • 81.88 (n)
  • 80.58 (a)
UPP1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
UPP1 35
  • 76.08 (n)
  • 70.13 (a)
mouse
(Mus musculus)
Mammalia Upp1 35
  • 82.04 (n)
  • 79.35 (a)
Upp1 16
Upp1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UPP1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UPP1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upp1 35
  • 81.94 (n)
  • 80.65 (a)
chicken
(Gallus gallus)
Aves UPP1 35
  • 70.23 (n)
  • 72.82 (a)
UPP1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9081 35
upp1 35
  • 69.75 (n)
  • 72.6 (a)
zebrafish
(Danio rerio)
Actinopterygii upp1 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17224 36
  • 43 (a)
ManyToMany
CG3788 35
  • 54.2 (n)
  • 49.3 (a)
CG3788 36
  • 38 (a)
ManyToMany
CG6330 36
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea upp-1 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
CSA.9473 36
  • 35 (a)
ManyToMany
CSA.9869 36
  • 37 (a)
ManyToMany
Species with no ortholog for UPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UPP1 Gene

ENSEMBL:
Gene Tree for UPP1 (if available)
TreeFam:
Gene Tree for UPP1 (if available)

Paralogs for UPP1 Gene

Paralogs for UPP1 Gene

Selected SIMAP similar genes for UPP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with UPP1: view

Variants for UPP1 Gene

Sequence variations from dbSNP and Humsavar for UPP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1050267 -- 48,090,215(+) CGCAG(A/C)TCGTC intron-variant, utr-variant-5-prime
rs1050268 -- 48,090,219(+) GCTCG(C/T)CGACA intron-variant, utr-variant-5-prime
rs1050269 -- 48,090,256(+) GCTTG(G/T)TGAGG utr-variant-5-prime, nc-transcript-variant
rs1131053 -- 48,108,249(+) AACCG(A/C)CTGGA synonymous-codon, reference, nc-transcript-variant
rs1131054 -- 48,108,251(+) CCGCC(A/T)GGAAG missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for UPP1 Gene

Variant ID Type Subtype PubMed ID
nsv470221 CNV Gain 18288195
nsv464442 CNV Gain 19166990
esv997355 CNV Deletion 20482838
esv2734369 CNV Deletion 23290073

Relevant External Links for UPP1 Gene

HapMap Linkage Disequilibrium report
UPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPP1 Gene

Disorders for UPP1 Gene

(9) Novoseek inferred disease relationships for UPP1 Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 38.2 1
colon cancer 33 2
cancer 27.2 9
tumors 17.8 5
colorectal cancer 15 2
genes like me logo Genes that share disorders with UPP1: view

No data available for UniProtKB/Swiss-Prot for UPP1 Gene

Publications for UPP1 Gene

  1. Expression of uridine and thymidine phosphorylase genes in human breast carcinoma. (PMID: 11807789) Kanzaki A. … Uchida T. (Int. J. Cancer 2002) 2 3 23
  2. Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. (PMID: 19291308) Roosild T.P. … Pizzorno G. (BMC Struct. Biol. 2009) 3 4 23
  3. Uridine phosphorylase association with vimentin. Intracellular distribution and localization. (PMID: 11278417) Russell R.L. … Pizzorno G. (J. Biol. Chem. 2001) 3 23
  4. Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1. (PMID: 19714313) Im Y.S. … Choi J.K. (Mol. Cells 2009) 3 23
  5. The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells. (PMID: 16798057) Temmink O.H. … Peters G.J. (Int. J. Biochem. Cell Biol. 2006) 3 23

Products for UPP1 Gene

Sources for UPP1 Gene

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