Aliases for UPP1 Gene
External Ids for UPP1 Gene
Previous Symbols for UPP1 Gene
The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 18.104.22.168) and thymidine phosphorylase (TP; EC 22.214.171.124), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
GeneCards Summary for UPP1 Gene
UPP1 (Uridine Phosphorylase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include uridine phosphorylase activity. An important paralog of this gene is UPP2.
UniProtKB/Swiss-Prot for UPP1 Gene
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis