Aliases for UPP1 Gene
External Ids for UPP1 Gene
Previous HGNC Symbols for UPP1 Gene
Previous GeneCards Identifiers for UPP1 Gene
The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 22.214.171.124) and thymidine phosphorylase (TP; EC 126.96.36.199), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
GeneCards Summary for UPP1 Gene
UPP1 (Uridine Phosphorylase 1) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (REACTOME) and Purine metabolism. GO annotations related to this gene include transferase activity, transferring pentosyl groups and uridine phosphorylase activity. An important paralog of this gene is UPP2.
UniProtKB/Swiss-Prot for UPP1 Gene
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.