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Aliases for UPK3BL Gene

Aliases for UPK3BL Gene

  • Uroplakin 3B-Like 2 3
  • Uroplakin-Like Protein 2 3
  • UPLP 3 4
  • Uroplakin-3b-Like Protein 3
  • Uroplakin-3-Like Protein 3

External Ids for UPK3BL Gene

Previous GeneCards Identifiers for UPK3BL Gene

  • GC07M102279
  • GC07M101637
  • GC07M102222
  • GC07M102283

Summaries for UPK3BL Gene

GeneCards Summary for UPK3BL Gene

UPK3BL (Uroplakin 3B-Like) is a Protein Coding gene. An important paralog of this gene is ENSG00000205236.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK3BL Gene

Genomics for UPK3BL Gene

Genomic Location for UPK3BL Gene

102,637,025 bp from pter
102,642,791 bp from pter
5,767 bases
Minus strand

Genomic View for UPK3BL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UPK3BL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPK3BL Gene

No data available for Regulatory Elements for UPK3BL Gene

Proteins for UPK3BL Gene

  • Protein details for UPK3BL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uroplakin-3b-like protein
    Protein Accession:
    Secondary Accessions:

    Protein attributes for UPK3BL Gene

    263 amino acids
    Molecular mass:
    28385 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UPK3BL Gene

Proteomics data for UPK3BL Gene at MOPED

Post-translational modifications for UPK3BL Gene

  • Ubiquitination at Lys148 and Lys164
  • Glycosylation at Asn51, Asn76, and Asn91
  • Modification sites at PhosphoSitePlus

Other Protein References for UPK3BL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UPK3BL Gene

Domains for UPK3BL Gene

Protein Domains for UPK3BL Gene


Suggested Antigen Peptide Sequences for UPK3BL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the uroplakin-3 family.
  • Belongs to the uroplakin-3 family.
genes like me logo Genes that share domains with UPK3BL: view

No data available for Gene Families for UPK3BL Gene

Function for UPK3BL Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UPK3BL Gene

Localization for UPK3BL Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK3BL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for UPK3BL Gene COMPARTMENTS Subcellular localization image for UPK3BL gene
Compartment Confidence
extracellular 3
plasma membrane 3
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UPK3BL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UPK3BL: view

Pathways for UPK3BL Gene

SuperPathways for UPK3BL Gene

No Data Available

Interacting Proteins for UPK3BL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000342938 for UPK3BL Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for UPK3BL Gene


No data available for Pathways by source for UPK3BL Gene

Transcripts for UPK3BL Gene

mRNA/cDNA for UPK3BL Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UPK3BL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPK3BL Gene

No ASD Table

Relevant External Links for UPK3BL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UPK3BL Gene

mRNA expression in normal human tissues for UPK3BL Gene

Protein differential expression in normal tissues for UPK3BL Gene

This gene is overexpressed in Nasal epithelium (68.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UPK3BL Gene

genes like me logo Genes that share expressions with UPK3BL: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for UPK3BL Gene

Orthologs for UPK3BL Gene

This gene was present in the common ancestor of chordates.

Orthologs for UPK3BL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UPK3BL 35
  • 77.96 (n)
  • 68.62 (a)
-- 36
  • 65 (a)
(Canis familiaris)
Mammalia UPK3BL 35
  • 78.67 (n)
  • 70 (a)
-- 36
  • 68 (a)
(Mus musculus)
Mammalia Upk3bl 35
  • 70.89 (n)
  • 63.32 (a)
Upk3bl 16
Upk3bl 36
  • 60 (a)
(Pan troglodytes)
Mammalia LOC101057620 35
  • 98.86 (n)
  • 99.24 (a)
-- 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Upk3bl 35
  • 70.6 (n)
  • 63.76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
(Gallus gallus)
Aves UPK3BL 35
  • 51.66 (n)
  • 39.34 (a)
-- 36
  • 38 (a)
(Danio rerio)
Actinopterygii upk3b 36
  • 22 (a)
Species with no ortholog for UPK3BL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UPK3BL Gene

Gene Tree for UPK3BL (if available)
Gene Tree for UPK3BL (if available)

Paralogs for UPK3BL Gene

Paralogs for UPK3BL Gene

(2) SIMAP similar genes for UPK3BL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UPK3BL: view

Variants for UPK3BL Gene

Structural Variations from Database of Genomic Variants (DGV) for UPK3BL Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
dgv7412n71 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026
dgv7418n71 CNV Gain 21882294
nsv888865 CNV Loss 21882294
dgv7419n71 CNV Loss 21882294
dgv7420n71 CNV Gain 21882294
esv7079 CNV Loss 19470904
dgv7421n71 CNV Gain+Loss 21882294
nsv888872 CNV Gain+Loss 21882294
nsv469682 CNV Complex 16826518
nsv471643 CNV Gain+Loss 15918152
nsv509219 CNV Insertion 20534489
dgv7423n71 CNV Loss 21882294
nsv888877 CNV Loss 21882294
dgv7424n71 CNV Gain 21882294
dgv7425n71 CNV Loss 21882294
nsv9 CNV Loss 15895083
nsv499135 CNV Loss 21111241
dgv7427n71 CNV Gain+Loss 21882294
dgv7428n71 CNV Gain+Loss 21882294
dgv7429n71 CNV Loss 21882294
dgv7430n71 CNV Gain+Loss 21882294
dgv7431n71 CNV Loss 21882294
dgv7432n71 CNV Loss 21882294
nsv888907 CNV Gain+Loss 21882294
dgv7433n71 CNV Loss 21882294
dgv7435n71 CNV Gain 21882294
nsv888921 CNV Gain 21882294
nsv482113 CNV Gain 20164927

Relevant External Links for UPK3BL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for UPK3BL Gene

Disorders for UPK3BL Gene

No disorders were found for UPK3BL Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for UPK3BL Gene

Publications for UPK3BL Gene

  1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  2. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for UPK3BL Gene

Sources for UPK3BL Gene

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