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Aliases for UPK3BL Gene

Aliases for UPK3BL Gene

  • Uroplakin 3B-Like 2 3 5
  • Uroplakin-Like Protein 2 3
  • UPLP 3 4
  • Uroplakin-3b-Like Protein 3
  • Uroplakin-3-Like Protein 3
  • Uroplakin 3C Protein 3

External Ids for UPK3BL Gene

Previous GeneCards Identifiers for UPK3BL Gene

  • GC07M102279
  • GC07M101637
  • GC07M102222
  • GC07M102283

Summaries for UPK3BL Gene

GeneCards Summary for UPK3BL Gene

UPK3BL (Uroplakin 3B-Like) is a Protein Coding gene. An important paralog of this gene is ENSG00000205236.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK3BL Gene

Genomics for UPK3BL Gene

Regulatory Elements for UPK3BL Gene

Enhancers for UPK3BL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F102572 0.2 ENCODE 10.5 +70.1 70111 1.2 CREB3L1 SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF207 SP3 REST ZFP41 CRYZP1 ENSG00000213385 FAM185A PMPCB ENSG00000236226 S100A11P1 LRWD1 SPDYE2 ENSG00000239486 UPK3BL
GH07F102870 1.3 FANTOM5 Ensembl ENCODE 9.3 -231.2 -231203 6.3 PKNOX1 SIN3A ELK1 FOS SP3 JUNB TBX21 PPARG SMARCA4 ETV4 LRRC17 POLR2J3 UPK3BL ARMC10 ORAI2 LRWD1 RN7SKP198
GH07F102834 1.1 Ensembl ENCODE 8.5 -193.4 -193398 3.4 TBL1XR1 JUN SIN3A RAD21 HIC1 ZNF316 ZNF366 PRDM10 FOS CREM RPL23AP95 POLR2J3 UPK3BL RASA4DP LRWD1 ARMC10 RNU6-1136P RN7SKP198
GH07F101947 1.2 Ensembl ENCODE 6.7 +694.8 694791 1.6 ATF1 CBX3 TBL1XR1 INSM2 RAD21 ZNF366 CREM REST TSHZ1 ZEB2 UPK3BL SPDYE6 ENSG00000272219 GC07P101859
GH07F101853 1.4 FANTOM5 Ensembl ENCODE 6.1 +784.2 784239 9.5 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 CUX1 ENSG00000213385 SH2B2 UPK3BL PRKRIP1 RASA4B GC07P101859 ENSG00000259294
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UPK3BL on UCSC Golden Path with GeneCards custom track

Genomic Location for UPK3BL Gene

Chromosome:
7
Start:
102,637,025 bp from pter
End:
102,642,791 bp from pter
Size:
5,767 bases
Orientation:
Minus strand

Genomic View for UPK3BL Gene

Genes around UPK3BL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPK3BL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPK3BL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPK3BL Gene

Proteins for UPK3BL Gene

  • Protein details for UPK3BL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B0FP48-UPK3L_HUMAN
    Recommended name:
    Uroplakin-3b-like protein
    Protein Accession:
    B0FP48

    Protein attributes for UPK3BL Gene

    Size:
    263 amino acids
    Molecular mass:
    28385 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UPK3BL Gene

Post-translational modifications for UPK3BL Gene

  • Ubiquitination at Lys 148 and Lys 164
  • Glycosylation at Asn 51, Asn 76, and Asn 91
  • Modification sites at PhosphoSitePlus

Other Protein References for UPK3BL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UPK3BL Gene

Domains & Families for UPK3BL Gene

Protein Domains for UPK3BL Gene

Suggested Antigen Peptide Sequences for UPK3BL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B0FP48

UniProtKB/Swiss-Prot:

UPK3L_HUMAN :
  • Belongs to the uroplakin-3 family.
Family:
  • Belongs to the uroplakin-3 family.
genes like me logo Genes that share domains with UPK3BL: view

No data available for Gene Families for UPK3BL Gene

Function for UPK3BL Gene

Animal Model Products

miRNA for UPK3BL Gene

miRTarBase miRNAs that target UPK3BL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UPK3BL Gene

Localization for UPK3BL Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK3BL Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for UPK3BL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UPK3BL: view

No data available for Subcellular locations from COMPARTMENTS for UPK3BL Gene

Pathways & Interactions for UPK3BL Gene

SuperPathways for UPK3BL Gene

No Data Available

Interacting Proteins for UPK3BL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342938%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000342938 B0FP48-UPK3L_HUMAN for UPK3BL Gene via STRING IID

Gene Ontology (GO) - Biological Process for UPK3BL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UPK3BL Gene

Transcripts for UPK3BL Gene

mRNA/cDNA for UPK3BL Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPK3BL Gene

No ASD Table

Relevant External Links for UPK3BL Gene

GeneLoc Exon Structure for
UPK3BL
ECgene alternative splicing isoforms for
UPK3BL

Expression for UPK3BL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UPK3BL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UPK3BL Gene

This gene is overexpressed in Nasal epithelium (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UPK3BL Gene



NURSA nuclear receptor signaling pathways regulating expression of UPK3BL Gene:

UPK3BL
genes like me logo Genes that share expression patterns with UPK3BL: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for UPK3BL Gene

Orthologs for UPK3BL Gene

This gene was present in the common ancestor of chordates.

Orthologs for UPK3BL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
LOC101057620 34
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia UPK3BL 34
  • 78.67 (n)
-- 35
  • 68 (a)
OneToMany
cow
(Bos Taurus)
Mammalia UPK3BL 34
  • 77.96 (n)
-- 35
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Upk3bl 34 16 35
  • 70.89 (n)
rat
(Rattus norvegicus)
Mammalia Upk3bl 34
  • 70.6 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves UPK3BL 34
  • 51.66 (n)
-- 35
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii upk3b 35
  • 22 (a)
OneToMany
Species where no ortholog for UPK3BL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UPK3BL Gene

ENSEMBL:
Gene Tree for UPK3BL (if available)
TreeFam:
Gene Tree for UPK3BL (if available)

Paralogs for UPK3BL Gene

Paralogs for UPK3BL Gene

(2) SIMAP similar genes for UPK3BL Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for UPK3BL Gene

genes like me logo Genes that share paralogs with UPK3BL: view

Variants for UPK3BL Gene

Sequence variations from dbSNP and Humsavar for UPK3BL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10255511 -- 102,644,584(+) ATTAG(C/T)CAGTC intron-variant, upstream-variant-2KB
rs1063549 -- 102,637,142(-) ggatt(A/G)caggc utr-variant-3-prime
rs112489501 -- 102,643,234(+) CCTCA(A/G)AAAAA intron-variant, upstream-variant-2KB
rs112626569 -- 102,637,262(+) CATGG(C/T)GGCGT utr-variant-3-prime
rs1140577 -- 102,637,253(-) TGCCC(A/G)GCTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UPK3BL Gene

Variant ID Type Subtype PubMed ID
dgv11541n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11547n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11550n54 CNV loss 21841781
dgv1944e212 CNV loss 25503493
dgv23n31 CNV gain 19718026
dgv3894e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv6538n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
esv27624 CNV gain+loss 19812545
esv2764015 CNV loss 21179565
esv3322158 CNV duplication 20981092
esv3353259 CNV duplication 20981092
esv3413878 CNV duplication 20981092
esv3891168 CNV gain+loss 25118596
esv3891171 CNV loss 25118596
esv7079 CNV loss 19470904
nsv1128957 CNV duplication 24896259
nsv1139905 CNV duplication 24896259
nsv1153617 CNV duplication 26484159
nsv428182 CNV gain 18775914
nsv469682 CNV gain+loss 16826518
nsv471643 CNV gain+loss 15918152
nsv482113 CNV gain 20164927
nsv499135 CNV loss 21111241
nsv509219 CNV insertion 20534489
nsv5879 CNV deletion 18451855
nsv608005 CNV gain 21841781
nsv608046 CNV loss 21841781
nsv608048 CNV loss 21841781
nsv608054 CNV loss 21841781
nsv608055 CNV gain 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897
nsv9 CNV deletion 15895083
nsv981563 CNV duplication 23825009

Relevant External Links for UPK3BL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UPK3BL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for UPK3BL Gene

Disorders for UPK3BL Gene

Relevant External Links for UPK3BL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UPK3BL

No disorders were found for UPK3BL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UPK3BL Gene

Publications for UPK3BL Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Generation of divergent uroplakin tetraspanins and their partners during vertebrate evolution: identification of novel uroplakins. (PMID: 24450554) Desalle R. … Garcia-Espana A. (BMC Evol. Biol. 2014) 3 64

Products for UPK3BL Gene

Sources for UPK3BL Gene

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