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Aliases for UPK3B Gene

Aliases for UPK3B Gene

  • Uroplakin 3B 2 3 5
  • Uroplakin IIIb 2 3 4
  • UPIIIB 3 4
  • UP3B 3 4
  • P35 3 4

External Ids for UPK3B Gene

Previous GeneCards Identifiers for UPK3B Gene

  • GC07P074676
  • GC07P075738
  • GC07P075751
  • GC07P075784
  • GC07P075977
  • GC07P076139
  • GC07P071187
  • GC07P076510

Summaries for UPK3B Gene

Entrez Gene Summary for UPK3B Gene

  • UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UPK3B Gene

UPK3B (Uroplakin 3B) is a Protein Coding gene. An important paralog of this gene is UPK3BL.

UniProtKB/Swiss-Prot for UPK3B Gene

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK3B Gene

Genomics for UPK3B Gene

Regulatory Elements for UPK3B Gene

Enhancers for UPK3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UPK3B on UCSC Golden Path with GeneCards custom track

Genomic Location for UPK3B Gene

9,510 bp from pter
14,763 bp from pter
5,254 bases
Plus strand

Genomic View for UPK3B Gene

Genes around UPK3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for UPK3B Gene

Proteins for UPK3B Gene

  • Protein details for UPK3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NHH5
    • A8K231
    • A8MZA8
    • B3KPU5
    • Q75MM5
    • Q86W06

    Protein attributes for UPK3B Gene

    320 amino acids
    Molecular mass:
    33882 Da
    Quaternary structure:
    • Heterodimer with uroplakin-1B (UPK1B).
    • Sequence=AAO89507.1; Type=Frameshift; Positions=210; Evidence={ECO:0000305}; Sequence=AAS07526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UPK3B Gene


neXtProt entry for UPK3B Gene

Proteomics data for UPK3B Gene at MOPED

Post-translational modifications for UPK3B Gene

  • Glycosylation at Asn 133
  • Modification sites at PhosphoSitePlus

Other Protein References for UPK3B Gene

No data available for DME Specific Peptides for UPK3B Gene

Domains & Families for UPK3B Gene

Protein Domains for UPK3B Gene


Suggested Antigen Peptide Sequences for UPK3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the uroplakin-3 family.
  • Belongs to the uroplakin-3 family.
genes like me logo Genes that share domains with UPK3B: view

No data available for Gene Families for UPK3B Gene

Function for UPK3B Gene

Molecular function for UPK3B Gene

UniProtKB/Swiss-Prot Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
genes like me logo Genes that share phenotypes with UPK3B: view

Animal Models for UPK3B Gene

MGI Knock Outs for UPK3B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UPK3B Gene

Localization for UPK3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK3B Gene

Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000269 PubMed:12446744}.

Subcellular locations from

Jensen Localization Image for UPK3B Gene COMPARTMENTS Subcellular localization image for UPK3B gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UPK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UPK3B: view

Pathways & Interactions for UPK3B Gene

SuperPathways for UPK3B Gene

No Data Available

Interacting Proteins for UPK3B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000257632 Q9BT76-UPK3B_HUMAN for UPK3B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for UPK3B Gene


No data available for Pathways by source and SIGNOR curated interactions for UPK3B Gene

Drugs & Compounds for UPK3B Gene

No Compound Related Data Available

Transcripts for UPK3B Gene

Unigene Clusters for UPK3B Gene

Uroplakin 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UPK3B Gene

No ASD Table

Relevant External Links for UPK3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UPK3B Gene

mRNA expression in normal human tissues for UPK3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPK3B Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x11.4), Bladder (x8.7), Esophagus - Mucosa (x8.4), and Lung (x5.7).

SOURCE GeneReport for Unigene cluster for UPK3B Gene Hs.488861

genes like me logo Genes that share expression patterns with UPK3B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for UPK3B Gene

Orthologs for UPK3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for UPK3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UPK3B 35
  • 83.88 (n)
  • 80 (a)
UPK3B 36
  • 46 (a)
(Canis familiaris)
Mammalia UPK3B 35
  • 84.32 (n)
  • 82.21 (a)
UPK3B 36
  • 42 (a)
(Mus musculus)
Mammalia Upk3b 35
  • 80.03 (n)
  • 82.54 (a)
Upk3b 16
Upk3b 36
  • 43 (a)
(Pan troglodytes)
Mammalia LOC100615896 35
  • 99.03 (n)
  • 98.19 (a)
UPK3B 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Upk3b 35
  • 79.63 (n)
  • 82.14 (a)
(Monodelphis domestica)
Mammalia UPK3B 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia UPK3B 36
  • 44 (a)
(Gallus gallus)
Aves UPK3B 35
  • 57.22 (n)
  • 47.21 (a)
UPK3B 36
  • 33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia upk3b 35
  • 46.58 (n)
  • 44.52 (a)
(Danio rerio)
Actinopterygii upk3b 36
  • 15 (a)
Species with no ortholog for UPK3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UPK3B Gene

Gene Tree for UPK3B (if available)
Gene Tree for UPK3B (if available)

Paralogs for UPK3B Gene

Paralogs for UPK3B Gene

(3) SIMAP similar genes for UPK3B Gene using alignment to 2 proteins: Pseudogenes for UPK3B Gene

genes like me logo Genes that share paralogs with UPK3B: view

Variants for UPK3B Gene

Sequence variations from dbSNP and Humsavar for UPK3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_034561 -
VAR_047805 -

Structural Variations from Database of Genomic Variants (DGV) for UPK3B Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2104e1 CNV Complex 17122850
esv2422494 CNV Duplication 17116639
nsv428174 CNV Gain 18775914
dgv232e55 CNV Gain 17911159
dgv2106e1 CNV Complex 17122850
dgv233e55 CNV Loss 17911159
nsv7403 OTHER Inversion 18451855
dgv2107e1 CNV Complex 17122850
dgv234e55 CNV Gain 17911159
dgv235e55 CNV Loss 17911159
nsv517634 CNV Gain+Loss 19592680
esv23516 CNV Gain 19812545
esv33074 CNV Gain 17666407
dgv7327n71 CNV Gain 21882294
dgv1218e199 CNV Deletion 23128226
nsv888391 CNV Loss 21882294
esv2734687 CNV Deletion 23290073
nsv888395 CNV Loss 21882294
dgv7328n71 CNV Gain 21882294
dgv121n16 CNV Insertion 17901297
nsv888401 CNV Gain+Loss 21882294
nsv888408 CNV Gain+Loss 21882294
nsv888410 CNV Gain 21882294
nsv888415 CNV Gain 21882294
nsv509211 CNV Insertion 20534489
nsv510964 CNV Complex 20534489
dgv7329n71 CNV Gain 21882294
dgv7330n71 CNV Gain 21882294
dgv7331n71 CNV Loss 21882294
nsv5797 CNV Loss 18451855
dgv63n64 CNV Loss 17921354
nsv482107 CNV Gain 20164927
nsv297 CNV Loss 15895083
esv2577198 CNV Loss 19546169
esv2666635 CNV Deletion 23128226
nsv8160 CNV Gain+Loss 18304495
dgv1118n67 CNV Loss 20364138
nsv821067 CNV Deletion 20802225
nsv499137 CNV Loss 21111241
esv23975 CNV Gain+Loss 19812545
nsv824175 CNV Gain 20364138
nsv515047 CNV Complex 21397061
esv32726 CNV Gain+Loss 17666407
dgv22n31 CNV Duplication 19718026
nsv824177 CNV Gain 20364138

Variation tolerance for UPK3B Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.36; 85.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UPK3B Gene

Disorders for UPK3B Gene

Relevant External Links for UPK3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UPK3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UPK3B Gene

Publications for UPK3B Gene

  1. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. (PMID: 12446744) Deng F.-M. … Sun T.-T. (J. Cell Biol. 2002) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. LRRN4 and UPK3B are markers of primary mesothelial cells. (PMID: 21984916) Kanamori-Katayama M. … Hayashizaki Y. (PLoS ONE 2011) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for UPK3B Gene

Sources for UPK3B Gene