Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UPK3B Gene

protein-coding   GIFtS: 44
GCID: GC07P076139

uroplakin 3B
 Explore 4 diseases affiliated with
UPK3B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UPK3B    

Aliases
for UPK3B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Uroplakin 3B1 2     FLJ321981
UPIIIb1 3     MGC109021
P352 5     UP3B2
Uroplakin IIIb2 3     Uroplakin-3b1
P352 5     UP3b3
UPIIIB2 5     

External Ids:    HGNC: 214441   Entrez Gene: 807612   Ensembl: ENSG000002435667   OMIM: 6118875   UniProtKB: Q9BT763   

Export aliases for UPK3B gene to outside databases

Previous GC identifers: GC07P074676 GC07P075738 GC07P075751 GC07P075784 GC07P075977 GC07P071187


Summaries
for UPK3B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UPK3B:
UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b
(UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral
membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et
al., 2002 (PubMed 12446744)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: UPK3B_HUMAN, Q9BT76
Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally
differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally
differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an
important role in preventing bacterial adherence (By similarity)




Genomic Views
for UPK3B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UPK3B gene promoter:
         MZF-1   Spz1   AML1a   NRF-2   CP2   ARP-1   Pax-4a   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UPK3B promoter sequence
   Search SABiosciences Chromatin IP Primers for UPK3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UPK3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.2   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.2

UPK3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPK3B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076139:  view genomic region     (about GC identifiers)

Start:
 76,139,745 bp from pter      End:
 76,648,340 bp from pter
Size:
 508,596 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,472,809-75,490,263     

Proteins
for UPK3B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UPK3B_HUMAN, Q9BT76 (See protein sequence)
Recommended Name: Uroplakin-3b precursor  
Size: 320 amino acids; 33882 Da
Subunit: Heterodimer with uroplakin-1B (UPK1B)
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential). Note=Heterodimer formation with
UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER)
Sequence caution: Sequence=AAO89507.1; Type=Frameshift; Positions=210; Sequence=AAS07526.1; Type=Erroneous gene model
prediction;
Secondary accessions: A8K231 A8MZA8 B3KPU5 Q75MM5 Q86W06
Alternative splicing: 2 isoforms:  Q9BT76-1   Q9BT76-2   

Explore the universe of human proteins at neXtProt for UPK3B: NX_Q9BT76

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BT76

    • UPK3B Protein expression data from MOPED and PaxDb:    About this image 
    UPK3B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_085047.1  NP_872624.1  NP_872625.1  

    ENSEMBL proteins: 
     ENSP00000334938   ENSP00000257632   ENSP00000378319   ENSP00000441602   ENSP00000441284  
     ENSP00000444585  

    Human Recombinant Protein Products for UPK3B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for UPK3B 
    GenScript Custom Purified and Recombinant Proteins Services for UPK3B
    Novus Biologicals UPK3B Protein
    Novus Biologicals UPK3B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UPK3B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    UPK3B for ontologies           About GeneDecksing



    UPK3B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UPK3B 
    GenScript Custom Superior Antibodies Services for UPK3B
    Novus Biologicals UPK3B Antibodies
    Abcam antibodies for UPK3B 
    Uscn Antibodies for UPK3B
    Search ThermoFisher Antibodies for UPK3B

    Assay Products for UPK3B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UPK3B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for UPK3B

    Protein Domains /
    Families
    for UPK3B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UPK3B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR024828 Uroplakin-3b
     IPR024831 Uroplakin-3

    Graphical View of Domain Structure for InterPro Entry Q9BT76

    ProtoNet protein and cluster: Q9BT76

    UniProtKB/Swiss-Prot: UPK3B_HUMAN, Q9BT76
    Similarity: Belongs to the uroplakin-3 family


    Function
    for UPK3B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UPK3B_HUMAN, Q9BT76
    Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally
    differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally
    differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an
    important role in preventing bacterial adherence (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for UPK3B:

     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UPK3B 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UPK3B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UPK3B
    SwitchGear 3'UTR luciferase reporter plasmid: UPK3B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UPK3B (see all 4)
    OriGene shRNA RFP: UPK3B
    OriGene siRNA: UPK3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UPK3B
    Sirion Biotech Custom design and validation of potent shRNA sequences against UPK3B 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UPK3B
    Sirion Biotech Customized adenovirus for overexpression of UPK3B 
    Sirion Biotech Customized adenovirus for potent knockdown of UPK3B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UPK3B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UPK3B (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): UPK3B (NM_182684)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UPK3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPK3B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for UPK3B
    Search LifeMap BioReagents cell lines for UPK3B
    Sirion Biotech Customized stable knockdown cell line services for UPK3B 
    Sirion Biotech Customized inducible knockdown cell line services for UPK3B
    Sirion Biotech Customized stable overexpressing cell line services for UPK3B
    Sirion Biotech Customized inducible overexpressing cell line services for UPK3B

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UPK3B


    Pathways & Interactions
    for UPK3B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UPK3B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for UPK3B (Q9BT763 ENSP000002576324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPK1BO758413, ENSP000002642344I2D: score=1 STRING: ENSP00000264234
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010629negative regulation of gene expression IMP18776082

    UPK3B for ontologies           About GeneDecksing



    Drugs & Compounds
    for UPK3B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UPK3B
    Search CenterWatch for drugs/clinical trials and news about UPK3B 

    Transcripts
    for UPK3B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UPK3B gene (3 alternative transcripts): 
    NM_030570.2  NM_182683.1  NM_182684.1  

    Unigene Cluster for UPK3B:

    Uroplakin 3B
    Hs.488861  [show with all ESTs]
    Unigene Representative Sequence: NM_030570
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334348(uc010ldk.1) ENST00000257632 ENST00000394849 ENST00000490360
    ENST00000469114 ENST00000419923 ENST00000448265(uc003ufo.3 uc003ufq.3)
    ENST00000443097

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UPK3B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UPK3B
    SwitchGear 3'UTR luciferase reporter plasmid: UPK3B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UPK3B (see all 4)
    OriGene shRNA RFP: UPK3B
    OriGene siRNA: UPK3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UPK3B
    Sirion Biotech Custom design and validation of potent shRNA sequences against UPK3B 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UPK3B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UPK3B (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): UPK3B (NM_182684)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UPK3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPK3B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UPK3B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UPK3B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UPK3B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UPK3B

    Additional cDNA sequence: 

    AK056760.1 AK290096.1 AY233462.1 BC004304.1 BC128439.1 

    4 DOTS entries:

    DT.95269765  DT.100739485  DT.87015106  DT.210789 

    24/59 AceView cDNA sequences (see all 59):

    BQ695124 BI489725 BE378901 BU150542 BE388690 BE563033 BE379381 BI767901 
    BE392462 BE395788 BE515303 BE392047 BM924928 BE735871 NM_030570 BP352210 
    BQ067150 BE780958 BP381559 NM_182684 BI824841 BM921749 AA323714 BE378075 

    GeneLoc Exon Structure


    Expression
    for UPK3B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UPK3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    UPK3B Expression
    About this image

    UPK3B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    AdiposeThoracic Perivascular AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    KidneyRenal Collecting Duct SystemKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UPK3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UPK3B

    SOURCE GeneReport for Unigene cluster: Hs.488861
        SABiosciences Custom PCR Arrays for UPK3B
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UPK3B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UPK3B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UPK3B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UPK3B
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UPK3B

    Orthologs
    for UPK3B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UPK3B gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UPK3B6
    UPK3BL6
    		 Uncharacterized protein
    		 30(a)
    23(a)
    		 1 ↔ many
    1 ↔ many
    		 19(4145354-4148977)
    19(4143387-4145053)
    zebrafish
    (Danio rerio)    		 Actinopterygii upk3l6
    		 uroplakin 3l
    		 16(a)
    		 1 → many
    		 5(60950865-60962871)


    ENSEMBL Gene Tree for UPK3B (if available)
    TreeFam Gene Tree for UPK3B (if available) 

    Paralogs
    for UPK3B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UPK3B gene
    UPK3BL2  POLR2J32  
    3 SIMAP similar genes for UPK3B using alignment to 2 protein entries:     UPK3B_HUMAN (see all proteins):
    PMS2P11    POLR2J3    UPK3BL

    UPK3B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UPK3B
    PGOHUM00000250954


    Genomic Variants
    for UPK3B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 41 variations for UPK3B
         15/40 CNVs (see all 40): 82043 69971 64866 9060 69973 82041 7646 52284 3686 94620 32925 94623 0611 69972 36709
         1 Inversion: 37295
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UPK3B
    DNA2.0 Custom Variant and Variant Library Synthesis for UPK3B

    Disorders / Diseases
    for UPK3B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UPK3B for disorders           About GeneDecksing

    OMIM gene information: 611887    OMIM disorders: --

    4 diseases for UPK3B:    About MalaCards
    williams-beuren syndrome    retinitis pigmentosa    retinitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for UPK3B:
    Williams-Beuren syndrome

    Export disorders for UPK3B gene to outside databases

    Publications
    for UPK3B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UPK3B gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with UPK3B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. (PubMed id 12446744)1, 2, 3, 9 Deng F.-M.... Sun T.-T. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. LRRN4 and UPK3B are markers of primary mesothelial ce lls. (PubMed id 21984916)1 Kanamori-Katayama M....Hayashizaki Y. (2011)
    6. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. (PubMed id 18776082)1 Foot N.J....Kumar S. (2008)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function. (PubMed id 16814572)1 Garcia-Espana A....Desalle R. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for UPK3B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UPK3B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80761 HGNC: 21444 AceView: UPK3B Ensembl:ENSG00000243566 euGenes: HUgn80761
    ECgene: UPK3B H-InvDB: UPK3B

    Other Databases showing UPK3B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UPK3B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UPK3B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UPK3B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UPK3B gene:
    Search GeneIP for patents involving UPK3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for UPK3B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for UPK3B  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UPK3B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UPK3B  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for UPK3B   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UPK3B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UPK3B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UPK3B   OriGene Custom Protein Services for UPK3B  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UPK3B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UPK3B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UPK3B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UPK3B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UPK3B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UPK3B
     GenScript Custom Purified and Recombinant Proteins Services for UPK3B GenScript cDNA clones with any tag delivered in your preferred vector for UPK3B
     GenScript Custom Assay Services for UPK3B GenScript Custom Superior Antibodies Services for UPK3B
     GenScript Custom overexpressing Cell Line Services for UPK3B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UPK3B promoter
     Search Chromatin IP Primers for UPK3B
     RT2 qPCR Primer Assay in human, mouse, rat UPK3B
     Search GNC Networks for UPK3B
     SABiosciences Custom PCR Arrays for UPK3B
     Search Tocris compounds for UPK3B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UPK3B antibodies
     UPK3B proteins
     UPK3B lysates
     Antibodies for UPK3B
     See all of Abcam's Antibodies, Kits and Proteins for UPK3B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     UPK3B Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for UPK3B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UPK3B
     SwitchGear 3'UTR luciferase reporter plasmids for UPK3B
     SwitchGear Promoter luciferase reporter plasmids for UPK3B
     Search ThermoFisher Antibodies for UPK3B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPK3B
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UPK3B
    Sirion Biotech Customized:
     stable knockdown cell line services for UPK3B
     inducible knockdown cell line services for UPK3B
     design and validation of potent shRNA sequences against UPK3B
     adenovirus for potent knockdown of UPK3B
     adenovirus for overexpression of UPK3B
     stable overexpressing cell line services for UPK3B
     inducible overexpressing cell line services for UPK3B
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      UPK3B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4