Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UPK3B Gene

protein-coding   GIFtS: 46
GCID: GC07P076139

Uroplakin 3B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Uroplakin 3B1 2     uroplakin-3b2
Uroplakin IIIb1 2 3     UP3b3
P352 5     UPIIIb3
UPIIIB2 5     p353
UP3B2     

External Ids:    HGNC: 214441   Entrez Gene: 807612   Ensembl: ENSG000002435667   OMIM: 6118875   UniProtKB: Q9BT763   

Export aliases for UPK3B gene to outside databases

Previous GC identifers: GC07P074676 GC07P075738 GC07P075751 GC07P075784 GC07P075977 GC07P071187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UPK3B Gene:
UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with
uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major
conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A
(MIM 611559) (Deng et al., 2002 (PubMed 12446744)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UPK3B Gene:
UPK3B (uroplakin 3B) is a protein-coding gene. Diseases associated with UPK3B include williams-beuren syndrome, and retinitis pigmentosa. An important paralog of this gene is UPK3BL.

UniProtKB/Swiss-Prot: UPK3B_HUMAN, Q9BT76
Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by
terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in
terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which
may play an important role in preventing bacterial adherence (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  NT_187561.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the UPK3B gene promoter:
         MZF-1   Spz1   AML1a   NRF-2   CP2   ARP-1   Pax-4a   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUPK3B promoter sequence
   Search Chromatin IP Primers for UPK3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UPK3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.2   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.2

UPK3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPK3B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076139:  view genomic region     (about GC identifiers)

Start:
76,139,745 bp from pter      End:
76,648,340 bp from pter
Size:
508,596 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,472,809-75,490,263     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UPK3B_HUMAN, Q9BT76 (See protein sequence)
Recommended Name: Uroplakin-3b precursor  
Size: 320 amino acids; 33882 Da
Subunit: Heterodimer with uroplakin-1B (UPK1B)
Sequence caution: Sequence=AAO89507.1; Type=Frameshift; Positions=210; Sequence=AAS07526.1; Type=Erroneous gene
model prediction;
Secondary accessions: A8K231 A8MZA8 B3KPU5 Q75MM5 Q86W06
Alternative splicing: 2 isoforms:  Q9BT76-1   Q9BT76-2   

Explore the universe of human proteins at neXtProt for UPK3B: NX_Q9BT76

Post-translational modifications: 

  • Glycosylation2 at Asn133
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (3 alternative transcripts): 
    NP_085047.1  NP_872624.1  NP_872625.1  

    ENSEMBL proteins: 
     ENSP00000334938   ENSP00000257632   ENSP00000378319   ENSP00000441602   ENSP00000441284  
     ENSP00000444585  

    UPK3B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UPK3B
    GenScript Custom Purified and Recombinant Proteins Services for UPK3B
    Novus Biologicals UPK3B Protein
    Novus Biologicals UPK3B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UPK3B

    UPK3B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UPK3B
    OriGene Custom Antibody Services for UPK3B
    Novus Biologicals UPK3B Antibodies
    Abcam antibodies for UPK3B
    Cloud-Clone Corp. Antibodies for UPK3B
    Search ThermoFisher Antibodies for UPK3B
    LSBio Antibodies in human, mouse, rat for UPK3B

    UPK3B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UPK3B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UPK3B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UPK3B
    Cloud-Clone Corp. CLIAs for UPK3B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR024828 Uroplakin-3b
     IPR024831 Uroplakin-3

    Graphical View of Domain Structure for InterPro Entry Q9BT76

    ProtoNet protein and cluster: Q9BT76

    UniProtKB/Swiss-Prot: UPK3B_HUMAN, Q9BT76
    Similarity: Belongs to the uroplakin-3 family


    UPK3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UPK3B_HUMAN, Q9BT76
    Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by
    terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in
    terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which
    may play an important role in preventing bacterial adherence (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for UPK3B:

     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UPK3B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UPK3B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UPK3B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UPK3B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UPK3B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UPK3B
    SwitchGear 3'UTR luciferase reporter plasmidUPK3B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UPK3B
    Predesigned siRNA for gene silencing in human, mouse, rat UPK3B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UPK3B

    Clone
    Products:
         
    OriGene clones in human, mouse for UPK3B (see all 9)
    OriGene ORF clones in mouse, rat for UPK3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UPK3B (NM_182684)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UPK3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPK3B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UPK3B
    Browse ESI BIO Cell Lines and PureStem Progenitors for UPK3B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPK3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UPK3B_HUMAN, Q9BT76: Cell membrane; Single-pass type I membrane protein (Potential). Note=Heterodimer formation
    with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    extracellular2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    UPK3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UPK3B
    Interactions:

        Search GeneGlobe Interaction Network for UPK3B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for UPK3B (Q9BT763 ENSP000002576324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPK1BO758413, ENSP000002642344I2D: score=1 STRING: ENSP00000264234
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010629negative regulation of gene expression IMP18776082

    UPK3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UPK3B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UPK3B gene (3 alternative transcripts): 
    NM_030570.2  NM_182683.1  NM_182684.1  

    Unigene Cluster for UPK3B:

    Uroplakin 3B
    Hs.488861  [show with all ESTs]
    Unigene Representative Sequence: NM_030570
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334348(uc010ldk.1) ENST00000257632 ENST00000394849 ENST00000490360
    ENST00000469114 ENST00000419923 ENST00000448265(uc003ufo.3 uc003ufq.3)
    ENST00000443097
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UPK3B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UPK3B
    SwitchGear 3'UTR luciferase reporter plasmidUPK3B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UPK3B
    Predesigned siRNA for gene silencing in human, mouse, rat UPK3B
    Clone
    Products:
         
    OriGene clones in human, mouse for UPK3B (see all 9)
    OriGene ORF clones in mouse, rat for UPK3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UPK3B (NM_182684)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UPK3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPK3B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UPK3B
    OriGene qSTAR qPCR primer pairs in human, mouse for UPK3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UPK3B
      QuantiTect SYBR Green Assays in human, mouse, rat UPK3B
      QuantiFast Probe-based Assays in human, mouse, rat UPK3B

    Additional mRNA sequence: 

    AK056760.1 AK290096.1 AY233462.1 BC004304.1 BC128439.1 

    4 DOTS entries:

    DT.95269765  DT.100739485  DT.87015106  DT.210789 

    Selected AceView cDNA sequences (see all 59):

    BE378901 BQ695124 BU150542 BI489725 BM921749 BE615406 BP352210 NM_182683 
    BE614826 BE780958 BE736746 BE395927 BM008901 BE379381 BE392462 BP381559 
    NM_182684 BI767901 BE378500 BI824841 BE394632 BE392047 BE394179 BE378075 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UPK3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UPK3B Expression
    About this image


    UPK3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Visceral White Adipocytes Visceral White Adipose
             Thoracic Perivascular Adipose
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    UPK3B Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.488861
        Custom PCR Arrays for UPK3B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UPK3B
    OriGene qSTAR qPCR primer pairs in human, mouse for UPK3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UPK3B
    QuantiTect SYBR Green Assays in human, mouse, rat UPK3B
    QuantiFast Probe-based Assays in human, mouse, rat UPK3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPK3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for UPK3B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Upk3b1 , 5 uroplakin 3B1, 5 80.03(n)1
    82.54(a)1
      5 (75.70 cM)5
    1006471  NM_175309.41  NP_780518.11 
     1360384965 
    chicken
    (Gallus gallus)
    Aves UPK3B1 uroplakin 3B 57.22(n)
    47.21(a)
      101749942  XM_004946836.1  XP_004946893.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia upk3b1 uroplakin 3B 46.58(n)
    44.52(a)
      100038143  XM_002933816.2  XP_002933862.2 
    zebrafish
    (Danio rerio)
    Actinopterygii upk3b6
    uroplakin 3b
    15(a)
    1 → many
    5(60950865-60962871) ENSDARG00000092872


    ENSEMBL Gene Tree for UPK3B (if available)
    TreeFam Gene Tree for UPK3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UPK3B gene
    UPK3BL2  ENSG000002052362  
    3 SIMAP similar genes for UPK3B using alignment to 2 protein entries:     UPK3B_HUMAN (see all proteins):
    PMS2P11    POLR2J3    UPK3BL

    UPK3B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UPK3B
    PGOHUM00000250954


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    2 SNPs for UPK3B    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17991261,2,4
    ----see VAR_0478052 mis40--------
    rs16366321,2,4
    ----see VAR_0345612 mis40--------

    HapMap Linkage Disequilibrium report for UPK3B (76139745 - 76389745 bp, first 250kb of UPK3B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UPK3B (see all 48):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666635CNV Deletion23128226
    dgv120n16CNV Deletion17901297
    esv2734687CNV Deletion23290073
    dgv1218e199CNV Deletion23128226
    nsv821067CNV Deletion20802225
    esv2422494CNV Duplication17116639
    dgv22n31CNV Duplication19718026
    nsv509211CNV Insertion20534489
    dgv121n16CNV Insertion17901297
    dgv1118n67CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UPK3B
    DNA2.0 Custom Variant and Variant Library Synthesis for UPK3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611887    OMIM disorders: --

    4 diseases for UPK3B:    
    About MalaCards
    williams-beuren syndrome    retinitis pigmentosa    retinitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for UPK3B:
    Williams-Beuren syndrome

    UPK3B for disorders           About GeneDecksing


    Export disorders for UPK3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UPK3B gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with UPK3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. (PubMed id 12446744)1, 2, 3, 9 Deng F.-M.... Sun T.-T. (J. Cell Biol. 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. LRRN4 and UPK3B are markers of primary mesothelial cells. (PubMed id 21984916)1 Kanamori-Katayama M....Hayashizaki Y. (PLoS ONE 2011)
    6. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. (PubMed id 18776082)1 Foot N.J.... Kumar S. (Blood 2008)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function. (PubMed id 16814572)1 Garcia-EspaA+a A....Desalle R. (Mol. Phylogenet. Evol. 2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80761 HGNC: 21444 AceView: UPK3B Ensembl:ENSG00000243566 euGenes: HUgn80761
    ECgene: UPK3B H-InvDB: UPK3B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UPK3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UPK3B gene:
    Search GeneIP for patents involving UPK3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UPK3B   OriGene RNAi products in human, mouse, rat for UPK3B  
     OriGene qPCR primer pairs and template standards for UPK3B   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UPK3B  
     OriGene qSTAR qPCR primer pairs in human, mouse for UPK3B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UPK3B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UPK3B   OriGene Custom Protein Services for UPK3B  

     
     
     Block miRNA regulation of human, mouse, rat UPK3B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UPK3B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UPK3B Predesigned siRNA for gene silencing in human, mouse, rat UPK3B
     QuantiFast Probe-based Assays in human, mouse, rat UPK3B QuantiTect SYBR Green Assays in human, mouse, rat UPK3B
     Custom PCR Arrays for UPK3B Search Chromatin IP Primers for UPK3B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UPK3B  Search GeneGlobe Interaction Network for UPK3B
     Regulatory tfbs in UPK3B promoter
     GenScript Custom Purified and Recombinant Proteins Services for UPK3B GenScript cDNA clones with any tag delivered in your preferred vector for UPK3B
     GenScript Custom Assay Services for UPK3B GenScript Custom overexpressing Cell Line Services for UPK3B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UPK3B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UPK3B antibodies
     UPK3B proteins
     UPK3B lysates
     Antibodies for UPK3B
     See all of Abcam's Antibodies, Kits and Proteins for UPK3B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UPK3B
     Antibodies for UPK3B
     ELISAs for UPK3B
     CLIAs for UPK3B



     Browse ESI BIO Cell Lines and PureStem Progenitors for UPK3B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPK3B
     SwitchGear 3'UTR luciferase reporter plasmids for UPK3B
     SwitchGear Promoter luciferase reporter plasmids for UPK3B
     Search ThermoFisher Antibodies for UPK3B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPK3B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UPK3B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UPK3B
     LSBio Antibodies in human, mouse, rat for UPK3B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UPK3B gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4