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Aliases for UPK2 Gene

Aliases for UPK2 Gene

  • Uroplakin 2 2 3
  • Uroplakin II 2 3 4
  • UPII 3 4 6
  • UP2 3 4 6
  • Uroplakin-2 2 3

External Ids for UPK2 Gene

Previous GeneCards Identifiers for UPK2 Gene

  • GC11P134018
  • GC11P120338
  • GC11P118829
  • GC11P118364
  • GC11P118332
  • GC11P114766
  • GC11P118795

Summaries for UPK2 Gene

Entrez Gene Summary for UPK2 Gene

  • This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]

GeneCards Summary for UPK2 Gene

UPK2 (Uroplakin 2) is a Protein Coding gene. Diseases associated with UPK2 include ovarian brenner tumor and bladder carcinoma in situ.

UniProtKB/Swiss-Prot for UPK2 Gene

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).

Gene Wiki entry for UPK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK2 Gene

Genomics for UPK2 Gene

Regulatory Elements for UPK2 Gene

Genomic Location for UPK2 Gene

Start:
118,925,164 bp from pter
End:
118,958,559 bp from pter
Size:
33,396 bases
Orientation:
Plus strand

Genomic View for UPK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPK2 Gene

Proteins for UPK2 Gene

  • Protein details for UPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00526-UPK2_HUMAN
    Recommended name:
    Uroplakin-2
    Protein Accession:
    O00526
    Secondary Accessions:
    • B0YJ92
    • O00457
    • Q53YV0

    Protein attributes for UPK2 Gene

    Size:
    184 amino acids
    Molecular mass:
    19438 Da
    Quaternary structure:
    • Interacts with uroplakin-1a (UPK1A).

neXtProt entry for UPK2 Gene

Proteomics data for UPK2 Gene at MOPED

Post-translational modifications for UPK2 Gene

  • Glycosylation at Asn28, Asn57, and Asn66
  • Modification sites at PhosphoSitePlus

Other Protein References for UPK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UPK2 Gene

Domains for UPK2 Gene

Protein Domains for UPK2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00526

UniProtKB/Swiss-Prot:

UPK2_HUMAN :
  • O00526
Family:
  • Belongs to the uroplakin-2 family.
genes like me logo Genes that share domains with UPK2: view

No data available for Gene Families for UPK2 Gene

Function for UPK2 Gene

Molecular function for UPK2 Gene

GENATLAS Biochemistry: uroplakin 2,urothelium specific transmembrane protein forming 12nm protein particles in association with other UPKs,at the asymetric unit membrane of the bladder epithelium,strenghthening and stabilizing the urothelial epithelial surface trough its interactions with the underlying cytoskeleton,continuously expressed by the majority of transitional cell carcinoma of the bladder (TCC), in a region of partial synteny to chromosome 11
UniProtKB/Swiss-Prot Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).

Gene Ontology (GO) - Molecular Function for UPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UPK2: view
genes like me logo Genes that share phenotypes with UPK2: view

Animal Models for UPK2 Gene

MGI Knock Outs for UPK2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UPK2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for UPK2 Gene

Localization for UPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK2 Gene

Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPK2 Gene COMPARTMENTS Subcellular localization image for UPK2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for UPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8175808
GO:0016324 apical plasma membrane IBA --
GO:0030176 integral component of endoplasmic reticulum membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UPK2: view

Pathways for UPK2 Gene

SuperPathways for UPK2 Gene

No Data Available

Interacting Proteins for UPK2 Gene

Gene Ontology (GO) - Biological Process for UPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development TAS 9515818
GO:0030855 epithelial cell differentiation IDA 10514386
GO:0061024 membrane organization IEA --
genes like me logo Genes that share ontologies with UPK2: view

No data available for Pathways by source for UPK2 Gene

Compounds for UPK2 Gene

(1) Novoseek inferred chemical compound relationships for UPK2 Gene

Compound -log(P) Hits PubMed IDs
troglitazone 47.2 2
genes like me logo Genes that share compounds with UPK2: view

Transcripts for UPK2 Gene

mRNA/cDNA for UPK2 Gene

(9) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UPK2 Gene

Uroplakin 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UPK2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for UPK2 Gene

GeneLoc Exon Structure for
UPK2
ECgene alternative splicing isoforms for
UPK2

Expression for UPK2 Gene

mRNA expression in normal human tissues for UPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPK2 Gene

This gene is overexpressed in Bladder (43.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UPK2 Gene

SOURCE GeneReport for Unigene cluster for UPK2 Gene Hs.379613

mRNA Expression by UniProt/SwissProt for UPK2 Gene

O00526-UPK2_HUMAN
Tissue specificity: Expressed in ureter.
genes like me logo Genes that share expressions with UPK2: view

In Situ Assay Products

Orthologs for UPK2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UPK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UPK2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UPK2 35
  • 87.68 (n)
  • 86.41 (a)
UPK2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UPK2 35
  • 90.58 (n)
  • 90.76 (a)
UPK2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Upk2 35
  • 84.24 (n)
  • 86.96 (a)
Upk2 16
Upk2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UPK2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upk2 35
  • 84.96 (n)
  • 86.96 (a)
Species with no ortholog for UPK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UPK2 Gene

ENSEMBL:
Gene Tree for UPK2 (if available)
TreeFam:
Gene Tree for UPK2 (if available)

Paralogs for UPK2 Gene

No data available for Paralogs for UPK2 Gene

Variants for UPK2 Gene

Sequence variations from dbSNP and Humsavar for UPK2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs537080 -- 118,955,335(+) CACCT(C/T)GGCCT upstream-variant-2KB
rs623500 -- 118,958,232(+) CAAGT(A/G)AGGAG reference, synonymous-codon
rs625291 -- 118,955,350(+) AAGTG(C/T)TGGGA upstream-variant-2KB
rs666191 -- 118,955,353(-) TAATC(C/T)CAGCA upstream-variant-2KB
rs666664 -- 118,957,969(+) gttgg(C/T)tggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UPK2 Gene

Variant ID Type Subtype PubMed ID
nsv819166 CNV Loss 19587683

Relevant External Links for UPK2 Gene

HapMap Linkage Disequilibrium report
UPK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPK2 Gene

Disorders for UPK2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for UPK2 Gene including...

Search for UPK2 Gene in MalaCards »

(8) Novoseek inferred disease relationships for UPK2 Gene

Disease -log(P) Hits PubMed IDs
bladder cancer 74.3 19
carcinoma transitional cell 70.9 5
metastasis 39.1 3
carcinoma 37.4 1
cancer 23.9 7
genes like me logo Genes that share disorders with UPK2: view

No data available for UniProtKB/Swiss-Prot for UPK2 Gene

Publications for UPK2 Gene

  1. Uroplakin gene expression by normal and neoplastic human urothelium. (PMID: 9846985) Lobban E.D. … Southgate J. (Am. J. Pathol. 1998) 2 3 4 23
  2. Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction. (PMID: 12792753) Hirata H. … Kanamaru T. (Oncol. Rep. 2003) 3 4 23
  3. Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. (PMID: 10404304) Yuasa T. … Okada Y. (Int. J. Urol. 1999) 3 23
  4. Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder. (PMID: 10458411) Li S.M. … Wu X.R. (J. Urol. 1999) 3 23
  5. Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. (PMID: 8175808) Wu X.R. … Sun T.T. (J. Biol. Chem. 1994) 3 23

Products for UPK2 Gene

Sources for UPK2 Gene

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