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Aliases for UPK2 Gene

Aliases for UPK2 Gene

  • Uroplakin 2 2 3 5
  • Uroplakin II 2 3 4
  • UPII 3 4
  • UP2 3 4
  • Uroplakin-2 2

External Ids for UPK2 Gene

Previous GeneCards Identifiers for UPK2 Gene

  • GC11P134018
  • GC11P120338
  • GC11P118829
  • GC11P118364
  • GC11P118332
  • GC11P114766
  • GC11P118795

Summaries for UPK2 Gene

Entrez Gene Summary for UPK2 Gene

  • This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]

GeneCards Summary for UPK2 Gene

UPK2 (Uroplakin 2) is a Protein Coding gene. Diseases associated with UPK2 include transitional cell carcinoma and bladder squamous cell carcinoma.

UniProtKB/Swiss-Prot for UPK2 Gene

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).

Gene Wiki entry for UPK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK2 Gene

Genomics for UPK2 Gene

Regulatory Elements for UPK2 Gene

Enhancers for UPK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UPK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UPK2 Gene

Chromosome:
11
Start:
118,925,164 bp from pter
End:
118,958,559 bp from pter
Size:
33,396 bases
Orientation:
Plus strand

Genomic View for UPK2 Gene

Genes around UPK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPK2 Gene

Proteins for UPK2 Gene

  • Protein details for UPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00526-UPK2_HUMAN
    Recommended name:
    Uroplakin-2
    Protein Accession:
    O00526
    Secondary Accessions:
    • B0YJ92
    • O00457
    • Q53YV0

    Protein attributes for UPK2 Gene

    Size:
    184 amino acids
    Molecular mass:
    19438 Da
    Quaternary structure:
    • Interacts with uroplakin-1a (UPK1A).

neXtProt entry for UPK2 Gene

Proteomics data for UPK2 Gene at MOPED

Post-translational modifications for UPK2 Gene

  • Glycosylation at Asn 28, Asn 57, and Asn 66
  • Modification sites at PhosphoSitePlus

Other Protein References for UPK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UPK2 Gene

Domains & Families for UPK2 Gene

Protein Domains for UPK2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00526

UniProtKB/Swiss-Prot:

UPK2_HUMAN :
  • Belongs to the uroplakin-2 family.
Family:
  • Belongs to the uroplakin-2 family.
genes like me logo Genes that share domains with UPK2: view

No data available for Gene Families for UPK2 Gene

Function for UPK2 Gene

Molecular function for UPK2 Gene

GENATLAS Biochemistry:
uroplakin 2,urothelium specific transmembrane protein forming 12nm protein particles in association with other UPKs,at the asymetric unit membrane of the bladder epithelium,strenghthening and stabilizing the urothelial epithelial surface trough its interactions with the underlying cytoskeleton,continuously expressed by the majority of transitional cell carcinoma of the bladder (TCC), in a region of partial synteny to chromosome 11
UniProtKB/Swiss-Prot Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).
genes like me logo Genes that share phenotypes with UPK2: view

Animal Models for UPK2 Gene

MGI Knock Outs for UPK2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UPK2 Gene

Localization for UPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK2 Gene

Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPK2 Gene COMPARTMENTS Subcellular localization image for UPK2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8175808
genes like me logo Genes that share ontologies with UPK2: view

Pathways & Interactions for UPK2 Gene

SuperPathways for UPK2 Gene

No Data Available

Interacting Proteins for UPK2 Gene

Gene Ontology (GO) - Biological Process for UPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 9515818
genes like me logo Genes that share ontologies with UPK2: view

No data available for Pathways by source and SIGNOR curated interactions for UPK2 Gene

Drugs & Compounds for UPK2 Gene

(1) Drugs for UPK2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with UPK2: view

Transcripts for UPK2 Gene

mRNA/cDNA for UPK2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UPK2 Gene

Uroplakin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UPK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for UPK2 Gene

GeneLoc Exon Structure for
UPK2
ECgene alternative splicing isoforms for
UPK2

Expression for UPK2 Gene

mRNA expression in normal human tissues for UPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPK2 Gene

This gene is overexpressed in Bladder (x43.8).

Protein differential expression in normal tissues from HIPED for UPK2 Gene

This gene is overexpressed in Urine (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UPK2 Gene



SOURCE GeneReport for Unigene cluster for UPK2 Gene Hs.379613

mRNA Expression by UniProt/SwissProt for UPK2 Gene

O00526-UPK2_HUMAN
Tissue specificity: Expressed in ureter.
genes like me logo Genes that share expression patterns with UPK2: view

Protein tissue co-expression partners for UPK2 Gene

Primer Products

In Situ Assay Products

Orthologs for UPK2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UPK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UPK2 35
  • 87.68 (n)
  • 86.41 (a)
UPK2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UPK2 35
  • 90.58 (n)
  • 90.76 (a)
UPK2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Upk2 35
  • 84.24 (n)
  • 86.96 (a)
Upk2 16
Upk2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upk2 35
  • 84.96 (n)
  • 86.96 (a)
oppossum
(Monodelphis domestica)
Mammalia UPK2 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UPK2 36
  • 99 (a)
OneToOne
Species with no ortholog for UPK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UPK2 Gene

ENSEMBL:
Gene Tree for UPK2 (if available)
TreeFam:
Gene Tree for UPK2 (if available)

Paralogs for UPK2 Gene

No data available for Paralogs for UPK2 Gene

Variants for UPK2 Gene

Sequence variations from dbSNP and Humsavar for UPK2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3886020 - 118,956,945(+) TGGTT(G/T)CCTTG reference, missense
rs45530531 - 118,958,157(+) CATCA(C/T)GGTGC reference, missense
rs537080 -- 118,955,335(+) CACCT(C/T)GGCCT upstream-variant-2KB
rs623500 -- 118,958,232(+) CAAGT(A/G)AGGAG reference, synonymous-codon
rs625291 -- 118,955,350(+) AAGTG(C/T)TGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UPK2 Gene

Variant ID Type Subtype PubMed ID
nsv819166 CNV Loss 19587683

Variation tolerance for UPK2 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UPK2 Gene

HapMap Linkage Disequilibrium report
UPK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPK2 Gene

Disorders for UPK2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for UPK2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
transitional cell carcinoma
  • transitional carcinoma
bladder squamous cell carcinoma
  • epidermoid carcinoma of the urinary bladder
bladder cancer, somatic
  • bladder carcinoma
cystitis cystica
- elite association - COSMIC cancer census association via MalaCards
Search UPK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UPK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UPK2
genes like me logo Genes that share disorders with UPK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UPK2 Gene

Publications for UPK2 Gene

  1. Uroplakin gene expression by normal and neoplastic human urothelium. (PMID: 9846985) Lobban E.D. … Southgate J. (Am. J. Pathol. 1998) 2 3 4 23 67
  2. Prostate stem cell antigen enhancer and uroplakin II promoter based bladder cancer targeted tissue-specific vector. (PMID: 18440837) Wang D. … Rodriguez R. (Urol. Oncol. 2010) 3 23
  3. Mutation analyses of Uroplakin II in children with renal tract malformations. (PMID: 17012268) Jenkins D. … Woolf A.S. (Nephrol. Dial. Transplant. 2006) 3 23
  4. Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector. (PMID: 16116969) Chen F. … Lu G. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2005) 3 23
  5. Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction. (PMID: 12792753) Hirata H. … Kanamaru T. (Oncol. Rep. 2003) 3 23

Products for UPK2 Gene

Sources for UPK2 Gene

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