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UPK1B Gene

protein-coding   GIFtS: 51
GCID: GC03P118892

Uroplakin 1B


(Previous symbol: UPK1)
  See UPK1B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Uroplakin 1B1 2     tetraspanin-202
UPK11 2     tspan-202
Uroplakin Ib2 3     uroplakin-1b2
TSPAN202 3     Tetraspanin-203
UP1b2 3     Tspan-203
UPIB2     UPIb3
tetraspan2     

External Ids:    HGNC: 125781   Entrez Gene: 73482   Ensembl: ENSG000001146387   OMIM: 6023805   UniProtKB: O758413   

Export aliases for UPK1B gene to outside databases

Previous GC identifers: GC03P115581 GC03P118521 GC03P120173 GC03P120213 GC03P120375 GC03P116267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UPK1B Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane
(AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal
bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in
stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites
has been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for UPK1B Gene:
UPK1B (uroplakin 1B) is a protein-coding gene. Diseases associated with UPK1B include ovarian brenner tumor. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is UPK1A.

UniProtKB/Swiss-Prot: UPK1B_HUMAN, O75841
Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by
terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology,
possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane
through AUM/cytoskeletal interactions (By similarity)

Gene Wiki entry for UPK1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UPK1B gene promoter:
         MEF-2A   PPAR-gamma1   aMEF-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUPK1B promoter sequence
   Search Chromatin IP Primers for UPK1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UPK1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.32   Ensembl cytogenetic band:  3q13.32   HGNC cytogenetic band: 3q13.32

UPK1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPK1B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P118892:  view genomic region     (about GC identifiers)

Start:
118,892,364 bp from pter      End:
118,924,000 bp from pter
Size:
31,637 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UPK1B_HUMAN, O75841 (See protein sequence)
Recommended Name: Uroplakin-1b  
Size: 260 amino acids; 29643 Da
Subunit: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B) (By similarity)
Secondary accessions: O60753 Q9UIM2 Q9UNX6

Explore the universe of human proteins at neXtProt for UPK1B: NX_O75841

Explore proteomics data for UPK1B at MOPED

Post-translational modifications: 

  • N-glycosylated with high-mannose oligosaccharides (By similarity)1
  • Modification sites at neXtProt

  • See UPK1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008883.2  
    ENSEMBL proteins: 
     ENSP00000418972   ENSP00000264234   ENSP00000418399   ENSP00000418597   ENSP00000418116  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    3 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2

    Graphical View of Domain Structure for InterPro Entry O75841

    ProtoNet protein and cluster: O75841

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: UPK1B_HUMAN, O75841
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Find genes that share domains with UPK1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UPK1B_HUMAN, O75841
    Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by
    terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology,
    possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane
    through AUM/cytoskeletal interactions (By similarity)

         Genatlas biochemistry entry for UPK1B:
    bovine uroplakin 1b homolog,forming 12nm protein particles in association with other UPKs,at the asymetric unit
    membrane of the bladder epithelium,strenghthening and stabilizing the urothelial epithelial surface trough its
    interactions with the underlying cytoskeleton,bladder specific,highly expressed in normal urothelium not in
    urothelial tumor cell lines

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS9935153
         
    Find genes that share ontologies with UPK1B           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Upk1b):
     normal 

    Find genes that share phenotypes with UPK1B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UPK1B
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    hsa-miR-3688-3p hsa-miR-409-3p hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-551b* hsa-miR-410 hsa-miR-4261
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UPK1B_HUMAN, O75841: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS9818021
    GO:0016324apical plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with UPK1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UPK1B
    Interactions:

        GeneGlobe Interaction Network for UPK1B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for UPK1B (O758413 ENSP000002642344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPK3BQ9BT763, ENSP000002576324I2D: score=1 STRING: ENSP00000257632
    UPK3AO756313, ENSP000002162114I2D: score=2 STRING: ENSP00000216211
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030855epithelial cell differentiation IDA10514386

    Find genes that share ontologies with UPK1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for UPK1B

    1 Novoseek inferred chemical compound relationship for UPK1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    troglitazone 54.7 2 15054105 (1)



    Find genes that share compounds with UPK1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UPK1B gene: 
    NM_006952.3  

    Unigene Cluster for UPK1B:

    Uroplakin 1B
    Hs.271580  [show with all ESTs]
    Unigene Representative Sequence: NM_006952
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497685 ENST00000264234(uc003ecc.3 uc011bix.2 uc003ecd.3)
    ENST00000479520 ENST00000494855 ENST00000460625
    miRNA
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    hsa-miR-3688-3p hsa-miR-409-3p hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-551b* hsa-miR-410 hsa-miR-4261
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      QuantiTect SYBR Green Assays in human, mouse, rat UPK1B
      QuantiFast Probe-based Assays in human, mouse, rat UPK1B

    Additional mRNA sequence: 

    AB002155.1 AB015234.1 AF042331.1 AF082888.1 AK225868.1 AK303924.1 AK313787.1 BC012851.2 
    BC063568.1 CR457084.1 

    5 DOTS entries:

    DT.430097  DT.95328979  DT.120855693  DT.91759021  DT.120855661 

    Selected AceView cDNA sequences (see all 84):

    AW519104 CB240996 BU689651 AA484313 CB851619 C00515 CA313343 CR624397 
    CR598921 AI982899 BM666154 CB321898 BC063568 AB002155 NM_006952 CA313053 
    AI689135 BX387757 BM955955 CD699850 BE206353 AA345951 AB015234 AW662222 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for UPK1B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:              -                                                   
    SP2:                                                                  


    ECgene alternative splicing isoforms for UPK1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UPK1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UPK1B Expression
    About this image


    UPK1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Kidney (Urinary System)
             Metanephros
    UPK1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UPK1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271580

    UniProtKB/Swiss-Prot: UPK1B_HUMAN, O75841
    Tissue specificity: Bladder epithelium

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UPK1B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Upk1b1 , 5 uroplakin 1B1, 5 87.18(n)1
    90.77(a)1
      16 (26.87 cM)5
    222681  NM_178924.41  NP_849255.21 
     387731845 
    chicken
    (Gallus gallus)
    Aves UPK1B1 uroplakin 1B 71.92(n)
    73.08(a)
      418345  XM_416567.4  XP_416567.3 
    lizard
    (Anolis carolinensis)
    Reptilia UPK1B6
    uroplakin 1B
    60(a)
    1 ↔ 1
    3(180877282-180901635)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041516.12   -- 78.22(n)    BC041516.1 


    ENSEMBL Gene Tree for UPK1B (if available)
    TreeFam Gene Tree for UPK1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UPK1B gene
    UPK1A2  
    2 SIMAP similar genes for UPK1B using alignment to 6 protein entries:     UPK1B_HUMAN (see all proteins):
    UPK1A    TSPAN18

    Find genes that share paralogs with UPK1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UPK1B (see all 738)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852878701,2
    --118890606(+) AGTCTA/CTTGTC 1 -- us2k10--------
    rs1455129031,2
    --118890711(+) TGCCTA/GAGACA 1 -- us2k10--------
    rs76443411,2
    C,F,A,H--118890804(+) TTGTAC/TGTTCT 1 -- us2k16Minor allele frequency- T:0.04NS EA CSA WA 540
    rs1144168891,2
    F--118890855(+) AAAAAT/CAGAAG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1510096011,2
    --118890875(+) GTCACC/TCATAT 1 -- us2k10--------
    rs130793341,2
    C,F,H--118890981(+) GATTAC/TACAAA 1 -- us2k129Minor allele frequency- N:0.00NS EA NA WA CSA 2888
    rs729550291,2
    C,F--118891204(+) AGGCCT/ATGTGA 1 -- us2k13Minor allele frequency- A:0.05WA 122
    rs29033011,2
    C,F,H--118891246(+) tgaagG/Tgggag 1 -- us2k123Minor allele frequency- T:0.33NS EA NA WA CSA 2349
    rs1902367101,2
    --118891304(+) AGCCCC/TTTTCA 1 -- us2k10--------
    rs1154923001,2
    F--118891321(+) GCCTCA/GGCTAC 1 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for UPK1B (118892364 - 118924000 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for UPK1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725821CNV Deletion23290073
    esv2725822CNV Deletion23290073
    nsv507119CNV Insertion20534489
    esv25249CNV Loss19812545
    nsv829692CNV Loss17160897
    nsv527259CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602380    OMIM disorders: --

    1 disease for UPK1B:    
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    ovarian brenner tumor

    2 diseases from the University of Copenhagen DISEASES database for UPK1B:
    Vesicoureteral reflux     Transitional cell carcinoma

    Find genes that share disorders with UPK1B           About GenesLikeMe

    3 Novoseek inferred disease relationships for UPK1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma transitional cell 66.6 4 9846985 (1), 9818021 (1), 12474225 (1)
    metastasis 2.54 2 9846985 (1), 12474225 (1)
    cancer 0 1 9935153 (1)

    Human Genome Epidemiology (HuGE) Navigator: UPK1B (1 document)

    Export disorders for UPK1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UPK1B gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with UPK1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Uroplakin gene expression by normal and neoplastic human urothelium. (PubMed id 9846985)1, 2, 3, 9 Lobban E.D.... Southgate J. (Am. J. Pathol. 1998)
    2. Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue. (PubMed id 9935153)1, 2, 3, 9 Finch J.L.... Cowled P.A. (Int. J. Cancer 1999)
    3. Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. (PubMed id 9818021)1, 2, 9 Yuasa T.... Okada Y. (Jpn. J. Cancer Res. 1998)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism. (PubMed id 9073521)1, 2 Finch J.L.... Cowled P.A. (Genomics 1997)
    6. Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma. (PubMed id 15140401)1, 9 Varga A.E....Cowled P.A. (Neoplasia 2004)
    7. Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. (PubMed id 8530366)1, 9 Wu X.R....Sun T.T. (J. Biol. Chem. 1995)
    8. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. (PubMed id 18355812)1, 9 Kalma Y....Barash A. (Fertil. Steril. 2009)
    9. Uroplakin Ib gene transcription in urothelial tumor cells is regulated by CpG methylation. (PubMed id 16354592)1, 9 Cowled P....Jackson P. (Neoplasia 2005)
    10. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. (PubMed id 12446744)1, 9 Deng F.-M.... Sun T.-T. (J. Cell Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7348 HGNC: 12578 AceView: UPK1B Ensembl:ENSG00000114638 euGenes: HUgn7348
    ECgene: UPK1B H-InvDB: UPK1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UPK1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UPK1B gene:
    Search GeneIP for patents involving UPK1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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