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Aliases for UPK1B Gene

Aliases for UPK1B Gene

  • Uroplakin 1B 2 3
  • Tetraspanin-20 3 4
  • Uroplakin Ib 3 4
  • Tspan-20 3 4
  • TSPAN20 3 4
  • UPIB 3 4
  • UP1b 3 4
  • Uroplakin-1b 3
  • Tetraspan 3
  • UPK1 3

External Ids for UPK1B Gene

Previous HGNC Symbols for UPK1B Gene

  • UPK1

Previous GeneCards Identifiers for UPK1B Gene

  • GC03P115581
  • GC03P118521
  • GC03P120173
  • GC03P120213
  • GC03P120375
  • GC03P118892
  • GC03P116267

Summaries for UPK1B Gene

Entrez Gene Summary for UPK1B Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UPK1B Gene

UPK1B (Uroplakin 1B) is a Protein Coding gene. Diseases associated with UPK1B include ovarian brenner tumor. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is UPK1A.

UniProtKB/Swiss-Prot for UPK1B Gene

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

Gene Wiki entry for UPK1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK1B Gene

Genomics for UPK1B Gene

Regulatory Elements for UPK1B Gene

Genomic Location for UPK1B Gene

Start:
119,173,517 bp from pter
End:
119,205,153 bp from pter
Size:
31,637 bases
Orientation:
Plus strand

Genomic View for UPK1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UPK1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPK1B Gene

Proteins for UPK1B Gene

  • Protein details for UPK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75841-UPK1B_HUMAN
    Recommended name:
    Uroplakin-1b
    Protein Accession:
    O75841
    Secondary Accessions:
    • O60753
    • Q9UIM2
    • Q9UNX6

    Protein attributes for UPK1B Gene

    Size:
    260 amino acids
    Molecular mass:
    29643 Da
    Quaternary structure:
    • Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).

neXtProt entry for UPK1B Gene

Proteomics data for UPK1B Gene at MOPED

Post-translational modifications for UPK1B Gene

Other Protein References for UPK1B Gene

No data available for DME Specific Peptides for UPK1B Gene

Domains for UPK1B Gene

Gene Families for UPK1B Gene

HGNC:

Protein Domains for UPK1B Gene

Suggested Antigen Peptide Sequences for UPK1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75841

UniProtKB/Swiss-Prot:

UPK1B_HUMAN :
  • O75841
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with UPK1B: view

Function for UPK1B Gene

Molecular function for UPK1B Gene

GENATLAS Biochemistry: bovine uroplakin 1b homolog,forming 12nm protein particles in association with other UPKs,at the asymetric unit membrane of the bladder epithelium,strenghthening and stabilizing the urothelial epithelial surface trough its interactions with the underlying cytoskeleton,bladder specific,highly expressed in normal urothelium not in urothelial tumor cell lines
UniProtKB/Swiss-Prot Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

Gene Ontology (GO) - Molecular Function for UPK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 9935153
genes like me logo Genes that share ontologies with UPK1B: view

Phenotypes for UPK1B Gene

MGI mutant phenotypes for UPK1B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with UPK1B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UPK1B Gene

Localization for UPK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPK1B Gene COMPARTMENTS Subcellular localization image for UPK1B gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for UPK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 9818021
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UPK1B: view

Pathways for UPK1B Gene

SuperPathways for UPK1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UPK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation IDA 10514386
genes like me logo Genes that share ontologies with UPK1B: view

No data available for Pathways by source for UPK1B Gene

Compounds for UPK1B Gene

(1) Novoseek inferred chemical compound relationships for UPK1B Gene

Compound -log(P) Hits PubMed IDs
troglitazone 54.7 1
genes like me logo Genes that share compounds with UPK1B: view

Transcripts for UPK1B Gene

Unigene Clusters for UPK1B Gene

Uroplakin 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UPK1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:

Relevant External Links for UPK1B Gene

GeneLoc Exon Structure for
UPK1B
ECgene alternative splicing isoforms for
UPK1B

Expression for UPK1B Gene

mRNA expression in normal human tissues for UPK1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPK1B Gene

This gene is overexpressed in Bladder (32.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UPK1B Gene

SOURCE GeneReport for Unigene cluster for UPK1B Gene Hs.271580

mRNA Expression by UniProt/SwissProt for UPK1B Gene

O75841-UPK1B_HUMAN
Tissue specificity: Bladder epithelium
genes like me logo Genes that share expressions with UPK1B: view

Orthologs for UPK1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for UPK1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UPK1B 35
  • 99.62 (n)
  • 99.62 (a)
cow
(Bos Taurus)
Mammalia UPK1B 35
  • 91.28 (n)
  • 93.46 (a)
UPK1B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UPK1B 35
  • 92.31 (n)
  • 95.38 (a)
UPK1B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Upk1b 35
  • 87.18 (n)
  • 90.77 (a)
Upk1b 16
Upk1b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UPK1B 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UPK1B 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upk1b 35
  • 86.03 (n)
  • 89.23 (a)
chicken
(Gallus gallus)
Aves UPK1B 35
  • 71.92 (n)
  • 73.08 (a)
UPK1B 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UPK1B 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia upk1b 35
  • 71.71 (n)
  • 68.6 (a)
Species with no ortholog for UPK1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UPK1B Gene

ENSEMBL:
Gene Tree for UPK1B (if available)
TreeFam:
Gene Tree for UPK1B (if available)

Paralogs for UPK1B Gene

Paralogs for UPK1B Gene

Selected SIMAP similar genes for UPK1B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UPK1B: view

Variants for UPK1B Gene

Sequence variations from dbSNP and Humsavar for UPK1B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2903301 -- 119,172,399(+) tgaag(G/T)gggag upstream-variant-2KB
rs3796355 -- 119,186,737(+) AATCC(C/T)GAAGA utr-variant-5-prime
rs3796356 -- 119,191,115(+) ACCTG(C/T)GGTCT intron-variant
rs3796357 -- 119,191,140(+) TTTTA(C/T)TTACT intron-variant
rs3796358 -- 119,191,337(+) CGAGT(G/T)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UPK1B Gene

Variant ID Type Subtype PubMed ID
nsv829692 CNV Loss 17160897
esv25249 CNV Loss 19812545
nsv507119 CNV Insertion 20534489
nsv527259 CNV Loss 19592680
esv2725821 CNV Deletion 23290073
esv2725822 CNV Deletion 23290073

Relevant External Links for UPK1B Gene

HapMap Linkage Disequilibrium report
UPK1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPK1B Gene

Disorders for UPK1B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UPK1B Gene including...

Search for UPK1B Gene in MalaCards »

(2) University of Copenhagen DISEASES for UPK1B Gene

(3) Novoseek inferred disease relationships for UPK1B Gene

Disease -log(P) Hits PubMed IDs
carcinoma transitional cell 66.6 3
metastasis 2.54 2
cancer 0 1

Relevant External Links for UPK1B

Human Genome Epidemiology (HuGE) Navigator
UPK1B
genes like me logo Genes that share disorders with UPK1B: view

No data available for UniProtKB/Swiss-Prot for UPK1B Gene

Publications for UPK1B Gene

  1. Uroplakin gene expression by normal and neoplastic human urothelium. (PMID: 9846985) Lobban E.D. … Southgate J. (Am. J. Pathol. 1998) 2 3 4 23
  2. Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue. (PMID: 9935153) Finch J.L. … Cowled P.A. (Int. J. Cancer 1999) 2 3 4 23
  3. Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. (PMID: 9818021) Yuasa T. … Okada Y. (Jpn. J. Cancer Res. 1998) 3 4 23
  4. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. (PMID: 18355812) Kalma Y. … Barash A. (Fertil. Steril. 2009) 3 23
  5. Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism. (PMID: 9073521) Finch J.L. … Cowled P.A. (Genomics 1997) 3 4

Products for UPK1B Gene

Sources for UPK1B Gene

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