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Aliases for UPK1B Gene

Aliases for UPK1B Gene

  • Uroplakin 1B 2 3 5
  • Tetraspanin-20 3 4
  • Uroplakin Ib 3 4
  • Tspan-20 3 4
  • TSPAN20 3 4
  • UPIB 3 4
  • UP1b 3 4
  • TETRASPAN 3
  • UPK1 3

External Ids for UPK1B Gene

Previous HGNC Symbols for UPK1B Gene

  • UPK1

Previous GeneCards Identifiers for UPK1B Gene

  • GC03P115581
  • GC03P118521
  • GC03P120173
  • GC03P120213
  • GC03P120375
  • GC03P118892
  • GC03P116267

Summaries for UPK1B Gene

Entrez Gene Summary for UPK1B Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UPK1B Gene

UPK1B (Uroplakin 1B) is a Protein Coding gene. Diseases associated with UPK1B include transitional cell carcinoma. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is UPK1A.

UniProtKB/Swiss-Prot for UPK1B Gene

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

Gene Wiki entry for UPK1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK1B Gene

Genomics for UPK1B Gene

Regulatory Elements for UPK1B Gene

Enhancers for UPK1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UPK1B on UCSC Golden Path with GeneCards custom track

Genomic Location for UPK1B Gene

Chromosome:
3
Start:
119,173,517 bp from pter
End:
119,205,153 bp from pter
Size:
31,637 bases
Orientation:
Plus strand

Genomic View for UPK1B Gene

Genes around UPK1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPK1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPK1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPK1B Gene

Proteins for UPK1B Gene

  • Protein details for UPK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75841-UPK1B_HUMAN
    Recommended name:
    Uroplakin-1b
    Protein Accession:
    O75841
    Secondary Accessions:
    • O60753
    • Q9UIM2
    • Q9UNX6

    Protein attributes for UPK1B Gene

    Size:
    260 amino acids
    Molecular mass:
    29643 Da
    Quaternary structure:
    • Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).

neXtProt entry for UPK1B Gene

Proteomics data for UPK1B Gene at MOPED

Post-translational modifications for UPK1B Gene

Other Protein References for UPK1B Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UPK1B

No data available for DME Specific Peptides for UPK1B Gene

Domains & Families for UPK1B Gene

Gene Families for UPK1B Gene

Protein Domains for UPK1B Gene

Suggested Antigen Peptide Sequences for UPK1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75841

UniProtKB/Swiss-Prot:

UPK1B_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with UPK1B: view

Function for UPK1B Gene

Molecular function for UPK1B Gene

GENATLAS Biochemistry:
bovine uroplakin 1b homolog,forming 12nm protein particles in association with other UPKs,at the asymetric unit membrane of the bladder epithelium,strenghthening and stabilizing the urothelial epithelial surface trough its interactions with the underlying cytoskeleton,bladder specific,highly expressed in normal urothelium not in urothelial tumor cell lines
UniProtKB/Swiss-Prot Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
genes like me logo Genes that share phenotypes with UPK1B: view

Animal Models for UPK1B Gene

MGI Knock Outs for UPK1B:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UPK1B Gene

Localization for UPK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPK1B Gene COMPARTMENTS Subcellular localization image for UPK1B gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for UPK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 9818021
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with UPK1B: view

Pathways & Interactions for UPK1B Gene

SuperPathways for UPK1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UPK1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UPK1B Gene

Drugs & Compounds for UPK1B Gene

(1) Drugs for UPK1B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with UPK1B: view

Transcripts for UPK1B Gene

Unigene Clusters for UPK1B Gene

Uroplakin 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UPK1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:

Relevant External Links for UPK1B Gene

GeneLoc Exon Structure for
UPK1B
ECgene alternative splicing isoforms for
UPK1B

Expression for UPK1B Gene

mRNA expression in normal human tissues for UPK1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPK1B Gene

This gene is overexpressed in Bladder (x32.7).

Protein differential expression in normal tissues from HIPED for UPK1B Gene

This gene is overexpressed in Urinary Bladder (32.0), Breast (27.8), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UPK1B Gene



SOURCE GeneReport for Unigene cluster for UPK1B Gene Hs.271580

mRNA Expression by UniProt/SwissProt for UPK1B Gene

O75841-UPK1B_HUMAN
Tissue specificity: Bladder epithelium.
genes like me logo Genes that share expression patterns with UPK1B: view

Protein tissue co-expression partners for UPK1B Gene

Primer Products

Orthologs for UPK1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for UPK1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UPK1B 35
  • 91.28 (n)
  • 93.46 (a)
UPK1B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UPK1B 35
  • 92.31 (n)
  • 95.38 (a)
UPK1B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Upk1b 35
  • 87.18 (n)
  • 90.77 (a)
Upk1b 16
Upk1b 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UPK1B 35
  • 99.62 (n)
  • 99.62 (a)
rat
(Rattus norvegicus)
Mammalia Upk1b 35
  • 86.03 (n)
  • 89.23 (a)
oppossum
(Monodelphis domestica)
Mammalia UPK1B 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UPK1B 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves UPK1B 35
  • 71.92 (n)
  • 73.08 (a)
UPK1B 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UPK1B 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia upk1b 35
  • 71.71 (n)
  • 68.6 (a)
Species with no ortholog for UPK1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UPK1B Gene

ENSEMBL:
Gene Tree for UPK1B (if available)
TreeFam:
Gene Tree for UPK1B (if available)

Paralogs for UPK1B Gene

Paralogs for UPK1B Gene

(2) SIMAP similar genes for UPK1B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UPK1B: view

Variants for UPK1B Gene

Sequence variations from dbSNP and Humsavar for UPK1B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9840317 - 119,190,312(+) ACAAC(A/G)AGACT reference, missense
rs4318547 -- 119,182,196(+) AAGAA(A/G)TACAA intron-variant
rs4322992 -- 119,181,922(+) TGTCT(A/G)TGTCA intron-variant
rs4446196 -- 119,172,827(+) ACTGC(A/G)GTTAC upstream-variant-2KB
rs4450805 -- 119,188,775(+) GCCTC(C/G)AATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UPK1B Gene

Variant ID Type Subtype PubMed ID
nsv829692 CNV Loss 17160897
esv25249 CNV Loss 19812545
nsv507119 CNV Insertion 20534489
nsv527259 CNV Loss 19592680
esv2725821 CNV Deletion 23290073
esv2725822 CNV Deletion 23290073

Variation tolerance for UPK1B Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UPK1B Gene

HapMap Linkage Disequilibrium report
UPK1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPK1B Gene

Disorders for UPK1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for UPK1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
transitional cell carcinoma
  • transitional carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search UPK1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for UPK1B

Human Genome Epidemiology (HuGE) Navigator
UPK1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UPK1B
genes like me logo Genes that share disorders with UPK1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UPK1B Gene

Publications for UPK1B Gene

  1. Uroplakin gene expression by normal and neoplastic human urothelium. (PMID: 9846985) Lobban E.D. … Southgate J. (Am. J. Pathol. 1998) 2 3 4 23 67
  2. Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue. (PMID: 9935153) Finch J.L. … Cowled P.A. (Int. J. Cancer 1999) 2 3 23
  3. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. (PMID: 18355812) Kalma Y. … Barash A. (Fertil. Steril. 2009) 3 23
  4. Uroplakin Ib gene transcription in urothelial tumor cells is regulated by CpG methylation. (PMID: 16354592) Cowled P. … Jackson P. (Neoplasia 2005) 3 23
  5. Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma. (PMID: 15140401) Varga A.E. … Cowled P.A. (Neoplasia 2004) 3 23

Products for UPK1B Gene

Sources for UPK1B Gene

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