Aliases for UPK1B Gene
External Ids for UPK1B Gene
Previous HGNC Symbols for UPK1B Gene
Previous GeneCards Identifiers for UPK1B Gene
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for UPK1B Gene
UPK1B (Uroplakin 1B) is a Protein Coding gene. Diseases associated with UPK1B include Transitional Cell Carcinoma. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is UPK1A.
UniProtKB/Swiss-Prot for UPK1B Gene
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).