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Aliases for UPK1A Gene

Aliases for UPK1A Gene

  • Uroplakin 1A 2 3
  • UPIA 3 4 6
  • Tetraspanin-21 3 4
  • Uroplakin Ia 3 4
  • Tspan-21 3 4
  • TSPAN21 3 4
  • UP1A 3 4
  • UPKA 3 4
  • Uroplakin-1a 3

External Ids for UPK1A Gene

Previous GeneCards Identifiers for UPK1A Gene

  • GC19P036796
  • GC19P036606
  • GC19P040833
  • GC19P040849
  • GC19P036157
  • GC19P032663

Summaries for UPK1A Gene

Entrez Gene Summary for UPK1A Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for UPK1A Gene

UPK1A (Uroplakin 1A) is a Protein Coding gene. Diseases associated with UPK1A include ovarian brenner tumor and transitional cell carcinoma. GO annotations related to this gene include protein homodimerization activity and monosaccharide binding. An important paralog of this gene is UPK1B.

UniProtKB/Swiss-Prot for UPK1A Gene

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

Gene Wiki entry for UPK1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK1A Gene

Genomics for UPK1A Gene

Regulatory Elements for UPK1A Gene

Genomic Location for UPK1A Gene

Start:
35,666,516 bp from pter
End:
35,678,485 bp from pter
Size:
11,970 bases
Orientation:
Plus strand

Genomic View for UPK1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UPK1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPK1A Gene

Proteins for UPK1A Gene

  • Protein details for UPK1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00322-UPK1A_HUMAN
    Recommended name:
    Uroplakin-1a
    Protein Accession:
    O00322
    Secondary Accessions:
    • Q3KNU5
    • Q3KNU6

    Protein attributes for UPK1A Gene

    Size:
    258 amino acids
    Molecular mass:
    28879 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with uroplakin-2 (UPK2) (By similarity).

    Alternative splice isoforms for UPK1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UPK1A Gene

Proteomics data for UPK1A Gene at MOPED

Post-translational modifications for UPK1A Gene

Other Protein References for UPK1A Gene

No data available for DME Specific Peptides for UPK1A Gene

Domains for UPK1A Gene

Gene Families for UPK1A Gene

HGNC:

Protein Domains for UPK1A Gene

Suggested Antigen Peptide Sequences for UPK1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00322

UniProtKB/Swiss-Prot:

UPK1A_HUMAN :
  • O00322
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with UPK1A: view

Function for UPK1A Gene

Molecular function for UPK1A Gene

GENATLAS Biochemistry: uroplakin 1A,urothelium specific transmembrane protein forming 12nm protein particles in association with other UPKs,at the asymetric unit membrane of the bladder epithelium,strenghthening and stabilizing the urothelial epithelial surface trough its interactions with the underlying cytoskeleton,continuously expressed by the majority of transitional cell carcinoma of the bladder (TCC), in a region of partial synteny to chromosome 11
UniProtKB/Swiss-Prot Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

Gene Ontology (GO) - Molecular Function for UPK1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity ISS --
GO:0048029 monosaccharide binding ISS --
genes like me logo Genes that share ontologies with UPK1A: view

Phenotypes for UPK1A Gene

genes like me logo Genes that share phenotypes with UPK1A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UPK1A Gene

Localization for UPK1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK1A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UPK1A Gene COMPARTMENTS Subcellular localization image for UPK1A gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 4
lysosome 1

Gene Ontology (GO) - Cellular Components for UPK1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005886 plasma membrane TAS 15088894
GO:0016021 integral component of membrane ISS --
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UPK1A: view

Pathways for UPK1A Gene

SuperPathways for UPK1A Gene

No Data Available

Interacting Proteins for UPK1A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000222275%0d%0a9606.ENSP00000264031%0d%0a
Selected Interacting proteins: ENSP00000222275 O00322-UPK1A_HUMAN for UPK1A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for UPK1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation IDA 10514386
GO:0051259 protein oligomerization ISS --
genes like me logo Genes that share ontologies with UPK1A: view

No data available for Pathways by source for UPK1A Gene

Compounds for UPK1A Gene

(1) Novoseek inferred chemical compound relationships for UPK1A Gene

Compound -log(P) Hits PubMed IDs
mannose 57.2 2
genes like me logo Genes that share compounds with UPK1A: view

Transcripts for UPK1A Gene

mRNA/cDNA for UPK1A Gene

(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UPK1A Gene

Uroplakin 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UPK1A Gene

No ASD Table

Relevant External Links for UPK1A Gene

GeneLoc Exon Structure for
UPK1A
ECgene alternative splicing isoforms for
UPK1A

Expression for UPK1A Gene

mRNA expression in normal human tissues for UPK1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPK1A Gene

This gene is overexpressed in Bladder (35.6) and Vagina (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UPK1A Gene

SOURCE GeneReport for Unigene cluster for UPK1A Gene Hs.159309

mRNA Expression by UniProt/SwissProt for UPK1A Gene

O00322-UPK1A_HUMAN
Tissue specificity: High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies.
genes like me logo Genes that share expressions with UPK1A: view

Orthologs for UPK1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for UPK1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UPK1A 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UPK1A 35
  • 89.28 (n)
  • 93.02 (a)
UPK1A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UPK1A 35
  • 89.84 (n)
  • 94.14 (a)
UPK1A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Upk1a 35
  • 88.31 (n)
  • 94.76 (a)
Upk1a 16
Upk1a 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UPK1A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UPK1A 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Upk1a 35
  • 88.73 (n)
  • 94.2 (a)
lizard
(Anolis carolinensis)
Reptilia UPK1A 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8143 35
zebrafish
(Danio rerio)
Actinopterygii upk1a 35
  • 54.13 (n)
  • 47.44 (a)
upk1a 36
  • 44 (a)
OneToOne
Species with no ortholog for UPK1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UPK1A Gene

ENSEMBL:
Gene Tree for UPK1A (if available)
TreeFam:
Gene Tree for UPK1A (if available)

Paralogs for UPK1A Gene

Paralogs for UPK1A Gene

Selected SIMAP similar genes for UPK1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UPK1A: view

Variants for UPK1A Gene

Sequence variations from dbSNP and Humsavar for UPK1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2267582 -- 35,665,319(+) GCCTC(A/G)TGGGC upstream-variant-2KB
rs2267583 -- 35,665,428(+) GCCAA(C/G)TCGTG upstream-variant-2KB
rs2267584 -- 35,665,686(+) TAAGC(A/G)CCCCT upstream-variant-2KB
rs2267585 -- 35,665,728(+) GCCTC(A/G)GTCCA upstream-variant-2KB
rs2285420 -- 35,677,970(+) TCCTC(A/G)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UPK1A Gene

Variant ID Type Subtype PubMed ID
dgv3852n71 CNV Loss 21882294
esv2666558 CNV Deletion 23128226
nsv526166 CNV Loss 19592680
nsv817832 CNV Loss 17921354

Relevant External Links for UPK1A Gene

HapMap Linkage Disequilibrium report
UPK1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPK1A Gene

Disorders for UPK1A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for UPK1A Gene including...

Search for UPK1A Gene in MalaCards »

(2) University of Copenhagen DISEASES for UPK1A Gene

(3) Novoseek inferred disease relationships for UPK1A Gene

Disease -log(P) Hits PubMed IDs
carcinoma transitional cell 52.3 1
bladder cancer 29.8 1
metastasis 0 1

Relevant External Links for UPK1A

Genetic Association Database (GAD)
UPK1A
Human Genome Epidemiology (HuGE) Navigator
UPK1A
genes like me logo Genes that share disorders with UPK1A: view

No data available for UniProtKB/Swiss-Prot for UPK1A Gene

Publications for UPK1A Gene

  1. Transcriptional control of the human urothelial-specific gene, uroplakin Ia. (PMID: 15913809) Hall G.D. … Chester J.D. (Biochim. Biophys. Acta 2005) 3 4 23
  2. Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. (PMID: 10404304) Yuasa T. … Okada Y. (Int. J. Urol. 1999) 2 3 23
  3. Uroplakin gene expression by normal and neoplastic human urothelium. (PMID: 9846985) Lobban E.D. … Southgate J. (Am. J. Pathol. 1998) 2 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity. (PMID: 15200408) Jiang S. … Sun T.T. (Kidney Int. 2004) 3 48

Products for UPK1A Gene

Sources for UPK1A Gene

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