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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UPF3A Gene

protein-coding   GIFtS: 51
GCID: GC13P115047

UPF3 regulator of nonsense transcripts homolog A (yeast)

  Search for UPF3A
in our new
 Human Malady Compendium 
Biological research products
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
UPF3 Regulator Of Nonsense Transcripts Homolog A (Yeast)1 2     Nonsense MRNA Reducing Factor 3A2 3
RENT3A1 2 3 5     Up-Frameshift Suppressor 3 Homolog A2 3
UPF31 2 3     HUpf31
HUPF3A1 2     Regulator Of Nonsense Transcripts 3A2

External Ids:    HGNC: 203321   Entrez Gene: 651102   Ensembl: ENSG000001690627   OMIM: 6055305   UniProtKB: Q9H1J13   

Export aliases for UPF3A gene to outside databases

Previous GC identifers: GC13P113408 GC13P111235 GC13P114068 GC13P112965 GC13P114065 GC13P095309


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UPF3A:
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export
and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects
exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation
ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling
protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is
located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1
Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the
nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the
cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex
(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown
to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In
vitro, weakly stimulates translation

Gene Wiki entry for UPF3A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024498.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UPF3A gene promoter:
         NF-1   NF-1/L   AML1a   STAT5A   Nkx5-1   AP-2gamma   c-Ets-1   Evi-1   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUPF3A promoter sequence
   Search SABiosciences Chromatin IP Primers for UPF3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UPF3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

UPF3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPF3A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P115047:  view genomic region     (about GC identifiers)

Start:
115,047,059 bp from pter      End:
115,071,283 bp from pter
Size:
24,225 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1 (See protein sequence)
Recommended Name: Regulator of nonsense transcripts 3A  
Size: 476 amino acids; 54696 Da
Subunit: Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex
(EJC). Interacts with UPF2 and RBM8A
Subcellular location: Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm
1 PDB 3D structure from and Proteopedia for UPF3A:
2L08 (3D)    
Secondary accessions: A2A366 Q5T8C3 Q5T8C9 Q7Z6N3 Q86YK1 Q9BZI8
Alternative splicing: 3 isoforms:  Q9H1J1-1   Q9H1J1-2   Q9H1J1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UPF3A: NX_Q9H1J1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H1J1

  • UPF3A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_075387.1  NP_542418.1  

    ENSEMBL proteins: 
     ENSP00000364448   ENSP00000329592  
    Reactome Protein details: Q9H1J1
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    Uscn Proteins for UPF3A

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11163187
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS11163187
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--


    UPF3A for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UPF3A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR005120 Nonsense_mediated_decay_UPF3
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9H1J1

    ProtoNet protein and cluster: Q9H1J1

    UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1
    Similarity: Belongs to the RENT3 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1
    Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the
    nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the
    cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex
    (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown
    to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In
    vitro, weakly stimulates translation

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005487nucleocytoplasmic transporter activity NAS11163187
    GO:0005515protein binding IPI12417715


    UPF3A for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon0.80
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.77
    Nonsense-Mediated Decay0.77
    Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A0.77
    2Metabolism of mRNA
    Metabolism of mRNA1.00
    Metabolism of RNA0.92
    3mRNA surveillance pathway
    mRNA surveillance pathway1.00
    4RNA transport
    RNA transport1.00
    5Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/7        Reactome Pathways for UPF3A (see all 7)
        Nonsense-Mediated Decay
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex
    Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A
    Metabolism of RNA
    Metabolism of mRNA


    2         Kegg Pathways  (Kegg details for UPF3A):
        RNA transport
    mRNA surveillance pathway


    UPF3A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UPF3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for UPF3A (Q9H1J11, 2, 3 ENSP000003644484) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF1Q929001, 2, 3, ENSP000002628034EBI-521530,EBI-373471 MINT-6539908 I2D: score=3 STRING: ENSP00000262803
    PIGTQ969N22, 3, ENSP000002790364MINT-65103 I2D: score=4 STRING: ENSP00000279036
    RBM8AQ9Y5S91, 3, ENSP000003330014EBI-521530,EBI-447231 I2D: score=4 STRING: ENSP00000333001
    UPF2Q9HAU52, 3, ENSP000003487084MINT-6539908 I2D: score=1 STRING: ENSP00000348708
    SMG1Q96Q152, 3, ENSP000004025154MINT-6539908 I2D: score=3 STRING: ENSP00000402515
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006913nucleocytoplasmic transport NAS11163187
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--


    UPF3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UPF3A
    Search CenterWatch for drugs/clinical trials and news about UPF3A / REN3A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UPF3A gene (2 alternative transcripts): 
    NM_023011.3  NM_080687.2  

    Unigene Cluster for UPF3A:

    UPF3 regulator of nonsense transcripts homolog A (yeast)
    Hs.533855  [show with all ESTs]
    Unigene Representative Sequence: NM_023011
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375299(uc010tkn.2 uc001vup.3 uc001vuq.3 uc001vur.3 uc001vut.3 uc001vuu.3)
    ENST00000492270 ENST00000351487 ENST00000484246 ENST00000480362 ENST00000474056
    ENST00000493727 ENST00000481131 ENST00000479712 ENST00000475218

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    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
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    Additional cDNA sequence: 

    AF318575.1 AK001069.1 AK302003.1 AY013250.1 BC008694.1 BC023569.1 

    24/29 DOTS entries (see all 29):

    DT.97847674  DT.40198088  DT.95100773  DT.40218661  DT.120791649  DT.75173882  DT.100792369  DT.75123646 
    DT.97847675  DT.91852926  DT.100792370  DT.95124464  DT.100672126  DT.102831760  DT.102831761  DT.95124461 
    DT.100027895  DT.120791613  DT.120791648  DT.91796201  DT.95124460  DT.97766040  DT.97847677  DT.100027894 

    24/262 AceView cDNA sequences (see all 262):

    AI633071 CA443872 AA385636 BM978325 W94343 CD244472 BM973184 AL541941 
    AA761766 CA425402 BG121109 BM698532 BM509963 CA438665 AW769463 BU678846 
    AI620857 BM823315 BM989095 CD300182 CA446293 BI335213 BQ019874 AK097027 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UPF3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTAAGAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See UPF3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UPF3A

    SOURCE GeneReport for Unigene cluster: Hs.533855

    UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1
    Tissue specificity: Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2
    is strongly expressed in fetal brain and spinal cord

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UPF3A gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves UPF3A1 UPF3 regulator of nonsense transcripts homolog A (yeast) 72.34(n)
    67.66(a)
      418734  XM_416933.3  XP_416933.2 
    lizard
    (Anolis carolinensis)
    Reptilia UPF3A6
    --
    65(a)
    1 ↔ 1
    3(106782604-106799339)
    zebrafish
    (Danio rerio)
    Actinopterygii upf3a1 UPF3 regulator of nonsense transcripts homolog A (yeast) 62.12(n)
    59.82(a)
      566608  NM_001202448.1  NP_001189377.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Upf36
    Upf3
    22(a)
    1 → many
    2R(19780589-19782510)
    worm
    (Caenorhabditis elegans)
    Secernentea smg-46
    Suppressor with Morphological effect on Genitalia ...
    19(a)
    1 → many
    V(9775912-9777719)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UPF36
    Smg-4/UPF3-like protein
    17(a)
    1 → many
    1(12351593-12355023)
    rice
    (Oryza sativa)
    Liliopsida --
    nonsense-mediated decay UPF3, putative, expressed
    16(a)
    1 → many
    4(21725135-21732811)


    ENSEMBL Gene Tree for UPF3A (if available)
    TreeFam Gene Tree for UPF3A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UPF3A gene
    UPF3B2  
    1 SIMAP similar gene for UPF3A using alignment to 2 protein entries:     REN3A_HUMAN (see all proteins):
    UPF3B

    UPF3A for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for UPF3A
    PGOHUM00000236936 PGOHUM00000236959 PGOHUM00000236281


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/634 NCBI SNPs in UPF3A are shown (see all 634    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849739881,2
    --115045189(+) TCATAC/TGGTTT 2 -- us2k10--------
    rs1477026831,2
    --115045221(+) AACAGC/GTGAAT 2 -- us2k10--------
    rs1385602361,2
    C,--115045240(+) CTACC-/ATTTTT 2 -- us2k10--------
    rs98058131,2
    C,F,A,H,--115045259(+) CATTTT/CTCAGA 2 -- us2k127Minor allele frequency- C:0.35NS EA NA WA CSA 2771
    rs1176024321,2
    --115045273(+) TTGCAA/GTAACA 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1151608351,2
    F,--115045356(+) GTTTAC/TGAAAT 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs741168701,2
    C,--115045363(+) AAATAT/CACACA 2 -- us2k12Minor allele frequency- C:0.08WA 120
    rs346279471,2
    C,F,--115045478(+) GAGGCC/AAACCT 2 -- us2k13Minor allele frequency- A:0.33NA 6
    rs1491624731,2
    --115045488(+) TGGCTC/TCAGAG 2 -- us2k10--------
    rs560025391,2
    C,--115045519(+) GAGAAC/GAGGGC 2 -- us2k12Minor allele frequency- G:0.08WA 120

    HapMap Linkage Disequilibrium report for UPF3A (115047059 - 115071283 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for UPF3A
         1 CNV: 71827

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UPF3A for disorders           About MalaCards

    UPF3A for disorders           About GeneDecksing

    OMIM gene information: 605530    OMIM disorders: --


    Export disorders for UPF3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UPF3A gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with UPF3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. (PubMed id 11163187)1, 2, 3, 9 Lykke-Andersen J....Steitz J.A. (2000)
    2. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). (PubMed id 11113196)1, 2, 3, 9 Serin G....Maquat L.E. (2001)
    3. Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. (PubMed id 16601204)1, 2, 9 Kunz J.B....Gehring N.H. (2006)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. (PubMed id 12554878)1, 2 Chiu S.-Y.... Maquat L.E. (2003)
    7. Role of the nonsense-mediated decay factor hUpf3 in the splicing- dependent exon-exon junction complex. (PubMed id 11546873)1, 2 Kim V.N.... Dreyfuss G. (2001)
    8. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. (PubMed id 11546874)1, 2 Lykke-Andersen J.... Steitz J.A. (2001)
    9. A UPF3-mediated regulatory switch that maintains RNA surveillance. (PubMed id 19503078)1, 9 Chan W.K....Wilkinson M.F. (2009)
    10. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. (PubMed id 15004547)1, 9 Kadlec J.... Cusack S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65110 HGNC: 20332 AceView: UPF3A Ensembl:ENSG00000169062 euGenes: HUgn65110
    ECgene: UPF3A Kegg: 65110 H-InvDB: UPF3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UPF3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UPF3A gene:
    Search GeneIP for patents involving UPF3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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