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UPF3A Gene

protein-coding   GIFtS: 53
GCID: GC13P115047

UPF3 Regulator Of Nonsense Transcripts Homolog A (Yeast)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UPF3 Regulator Of Nonsense Transcripts Homolog A (Yeast)1 2     UPF32 3
RENT3A2 3 5     hUpf32 3
Nonsense MRNA Reducing Factor 3A2 3     HUPF3A2
Up-Frameshift Suppressor 3 Homolog A2 3     Regulator Of Nonsense Transcripts 3A2

External Ids:    HGNC: 203321   Entrez Gene: 651102   Ensembl: ENSG000001690627   OMIM: 6055305   UniProtKB: Q9H1J13   

Export aliases for UPF3A gene to outside databases

Previous GC identifers: GC13P113408 GC13P111235 GC13P114068 GC13P112965 GC13P114065 GC13P095309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UPF3A Gene:
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear
export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA
surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay
(NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs
containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting
as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of
exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for UPF3A Gene:
UPF3A (UPF3 regulator of nonsense transcripts homolog A (yeast)) is a protein-coding gene. GO annotations related to this gene include nucleocytoplasmic transporter activity and RNA binding. An important paralog of this gene is UPF3B.

UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1
Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with
the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2
at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance
complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However,
UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon
junctions. In vitro, weakly stimulates translation

Gene Wiki entry for UPF3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024498.13  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UPF3A gene promoter:
         NF-1   NF-1/L   AML1a   STAT5A   Nkx5-1   AP-2gamma   c-Ets-1   Evi-1   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUPF3A promoter sequence
   Search Chromatin IP Primers for UPF3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UPF3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

UPF3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPF3A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P115047:  view genomic region     (about GC identifiers)

Start:
115,047,059 bp from pter      End:
115,071,292 bp from pter
Size:
24,234 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1 (See protein sequence)
Recommended Name: Regulator of nonsense transcripts 3A  
Size: 476 amino acids; 54696 Da
Subunit: Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction
complex (EJC). Interacts with UPF2 and RBM8A
1 PDB 3D structure from and Proteopedia for UPF3A:
2L08 (3D)    
Secondary accessions: A2A366 Q5T8C3 Q5T8C9 Q7Z6N3 Q86YK1 Q9BZI8
Alternative splicing: 3 isoforms:  Q9H1J1-1   Q9H1J1-2   Q9H1J1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UPF3A: NX_Q9H1J1

Explore proteomics data for UPF3A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UPF3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_075387.1  NP_542418.1  

    ENSEMBL proteins: 
     ENSP00000364448   ENSP00000329592  
    Reactome Protein details: Q9H1J1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR005120 Nonsense_mediated_decay_UPF3

    Graphical View of Domain Structure for InterPro Entry Q9H1J1

    ProtoNet protein and cluster: Q9H1J1

    UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1
    Similarity: Belongs to the RENT3 family


    Find genes that share domains with UPF3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REN3A_HUMAN, Q9H1J1
    Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with
    the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2
    at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance
    complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However,
    UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon
    junctions. In vitro, weakly stimulates translation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005487nucleocytoplasmic transporter activity NAS11163187
    GO:0005515protein binding IPI11163187
         
    Find genes that share ontologies with UPF3A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UPF3A
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    Selected qRT-PCR Assays for microRNAs that regulate UPF3A (see all 22):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidUPF3A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REN3A_HUMAN, Q9H1J1: Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11163187
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS11163187
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with UPF3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UPF3A About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    Nonsense-Mediated Decay0.89
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    2Gene Expression
    Gene Expression0.40
    3RNA transport
    RNA transport
    4mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with UPF3A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for UPF3A
        Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


    2 Kegg Pathways  (Kegg details for UPF3A):
        RNA transport
    mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UPF3A
    Interactions:

        GeneGlobe Interaction Network for UPF3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UPF3A (Q9H1J11, 2, 3 ENSP000003644484) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF1Q929001, 2, 3, ENSP000002628034EBI-521530,EBI-373471 MINT-6539908 I2D: score=3 STRING: ENSP00000262803
    PIGTQ969N22, 3, ENSP000002790364MINT-65103 I2D: score=4 STRING: ENSP00000279036
    RBM8AQ9Y5S91, 3, ENSP000003330014EBI-521530,EBI-447231 I2D: score=4 STRING: ENSP00000333001
    UPF2Q9HAU52, 3, ENSP000003487084MINT-6539908 I2D: score=1 STRING: ENSP00000348708
    SMG1Q96Q152, 3, ENSP000004025154MINT-6539908 I2D: score=3 STRING: ENSP00000402515
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006913nucleocytoplasmic transport NAS11163187
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    Find genes that share ontologies with UPF3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UPF3A (REN3A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UPF3A gene (2 alternative transcripts): 
    NM_023011.3  NM_080687.2  

    Unigene Cluster for UPF3A:

    UPF3 regulator of nonsense transcripts homolog A (yeast)
    Hs.533855  [show with all ESTs]
    Unigene Representative Sequence: NM_023011
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375299(uc010tkn.2 uc001vup.3 uc001vuq.3 uc001vur.3 uc001vut.3 uc001vuu.3)
    ENST00000492270 ENST00000351487 ENST00000484246 ENST00000480362 ENST00000474056
    ENST00000493727 ENST00000481131 ENST00000479712 ENST00000475218
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UPF3A (see all 22):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
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      QuantiFast Probe-based Assays in human, mouse, rat UPF3A

    Additional mRNA sequence: 

    AF318575.1 AK001069.1 AK302003.1 AY013250.1 BC008694.1 BC023569.1 

    Selected DOTS entries (see all 29):

    DT.97847674  DT.40198088  DT.95100773  DT.40218661  DT.120791649  DT.75173882  DT.100792369  DT.75123646 
    DT.97847675  DT.91852926  DT.100792370  DT.95124464  DT.100672126  DT.102831760  DT.102831761  DT.95124461 
    DT.100027895  DT.120791613  DT.120791648  DT.91796201  DT.95124460  DT.97766040  DT.97847677  DT.100027894 

    Selected AceView cDNA sequences (see all 262):

    BM509963 BU737129 AL541941 BI335213 AA034360 AA452506 AI554217 AA857910 
    BM503819 BM698532 AI081872 CD722111 AI951764 BM989095 BG742891 AI206468 
    BG121109 BM672052 CA438773 BM823315 CA446293 CA412318 BX506106 BU678846 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UPF3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTAAGAAT
    UPF3A Expression
    About this image

    UPF3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UPF3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533855

    UniProtKB/Swiss-Prot: REN3A_HUMAN, Q9H1J1
    Tissue specificity: Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord.
    Isoform 2 is strongly expressed in fetal brain and spinal cord

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPF3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UPF3A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Upf3a1 , 5 UPF3 regulator of nonsense transcripts homolog A (yeast)1, 5 75.95(n)1
    72.62(a)1
      8 (6.38 cM)5
    670311  NM_025924.21  NP_080200.11 
     137856155 
    chicken
    (Gallus gallus)
    Aves UPF3A1 UPF3 regulator of nonsense transcripts homolog A (yeast) 72.34(n)
    67.02(a)
      418734  XM_416933.4  XP_416933.2 
    lizard
    (Anolis carolinensis)
    Reptilia UPF3A6
    UPF3 regulator of nonsense transcripts homolog A (...
    66(a)
    1 ↔ 1
    3(106778991-106799339)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia upf3a1 UPF3 regulator of nonsense transcripts homolog A (yeast) 69.41(n)
    69.15(a)
      100492664  XM_004911795.1  XP_004911852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii upf3a1 UPF3 regulator of nonsense transcripts homolog A (yeast) 62.12(n)
    60.05(a)
      566608  NM_001202448.1  NP_001189377.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Upf36
    Upf3
    23(a)
    1 → many
    2R(19780589-19782510)
    worm
    (Caenorhabditis elegans)
    Secernentea smg-46
    Protein SMG-4, isoform b
    23(a)
    1 → many
    V(9775936-9777743) WBGene00004882


    ENSEMBL Gene Tree for UPF3A (if available)
    TreeFam Gene Tree for UPF3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UPF3A gene
    UPF3B2  
    1 SIMAP similar gene for UPF3A using alignment to 2 protein entries:     REN3A_HUMAN (see all proteins):
    UPF3B

    Find genes that share paralogs with UPF3A           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for UPF3A
    PGOHUM00000236936 PGOHUM00000236959 PGOHUM00000236281


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UPF3A (see all 767)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849739881,2
    --96133089(+) TCATAC/TGGTTT 2 -- us2k10--------
    rs1477026831,2
    --96133121(+) AACAGC/GTGAAT 2 -- us2k10--------
    rs1385602361,2
    C--96133140(+) CTACC-/ATTTTT 2 -- us2k10--------
    rs98058131,2
    C,F,A,H--96133159(+) CATTTT/CTCAGA 2 -- us2k127Minor allele frequency- C:0.35NS EA NA WA CSA 2771
    rs1176024321,2
    F--96133173(+) TTGCAA/GTAACA 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1151608351,2
    F--96133256(+) GTTTAC/TGAAAT 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs741168701,2
    C,F--96133263(+) AAATAT/CACACA 2 -- us2k12Minor allele frequency- C:0.08WA 120
    rs346279471,2
    C,F--96133378(+) GAGGCC/AAACCT 2 -- us2k13Minor allele frequency- A:0.33NA 6
    rs1491624731,2
    --96133388(+) TGGCTC/TCAGAG 2 -- us2k10--------
    rs560025391,2
    C,F--96133419(+) GAGAAC/GAGGGC 2 -- us2k12Minor allele frequency- G:0.08WA 120

    HapMap Linkage Disequilibrium report for UPF3A (115047059 - 115071292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for UPF3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1401261CNV Insertion17803354
    nsv64869CNV Insertion16902084
    esv1000540CNV Insertion20482838
    nsv826841CNV Loss20364138
    nsv518491CNV Loss19592680
    nsv901115CNV Gain21882294
    nsv901116CNV Gain21882294
    esv25715CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605530    OMIM disorders: --


    Find genes that share disorders with UPF3A           About GenesLikeMe

    Genetic Association Database (GAD): UPF3A

    Export disorders for UPF3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UPF3A gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with UPF3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. (PubMed id 11163187)1, 2, 3, 9 Lykke-Andersen J.... Steitz J.A. (Cell 2000)
    2. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). (PubMed id 11113196)1, 2, 3, 9 Serin G.... Maquat L.E. (Mol. Cell. Biol. 2001)
    3. Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. (PubMed id 16601204)1, 2, 9 Kunz J.B.... Gehring N.H. (RNA 2006)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. (PubMed id 12554878)1, 2 Chiu S.-Y.... Maquat L.E. (RNA 2003)
    7. Role of the nonsense-mediated decay factor hUpf3 in the splicing- dependent exon-exon junction complex. (PubMed id 11546873)1, 2 Kim V.N.... Dreyfuss G. (Science 2001)
    8. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. (PubMed id 11546874)1, 2 Lykke-Andersen J.... Steitz J.A. (Science 2001)
    9. A UPF3-mediated regulatory switch that maintains RNA surveillance. (PubMed id 19503078)1, 9 Chan W.K....Wilkinson M.F. (amp 2009)
    10. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. (PubMed id 15004547)1, 9 Kadlec J.... Cusack S. (Nat. Struct. Mol. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65110 HGNC: 20332 AceView: UPF3A Ensembl:ENSG00000169062 euGenes: HUgn65110
    ECgene: UPF3A Kegg: 65110 H-InvDB: UPF3A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UPF3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UPF3A gene:
    Search GeneIP for patents involving UPF3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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