UPF1 Gene
protein-coding GIFtS : 60 GCID: GC19 P018942
UPF1 regulator of nonsense transcripts homolog (yeast) regulator of nonsense transcripts 1 )RENT1 )
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Aliasesfor UPF1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases UPF1 Regulator Of Nonsense Transcripts Homolog (Yeast) 1 2 ATP-Dependent Helicase RENT12 3 RENT11 2 3 5 Delta Helicase2 NORF11 2 3 Smg-2 Homolog, Nonsense Mediated MRNA Decay Factor2 HUPF11 2 UP Frameshift 12 PNORF11 Up-Frameshift Mutation 1 Homolog2 Regulator Of Nonsense Transcripts 11 2 Yeast Upf1p Homolog2 Smg-21 EC 3.6.4.-3 KIAA02211 3 HUpf11 Nonsense MRNA Reducing Factor 12 3 EC 3.6.18 Up-Frameshift Suppressor 1 Homolog2 3
Export aliases for UPF1 gene to outside databases Previous GC identifers: GC19P018804 GC19P018507
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Summariesfor UPF1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for UPF1 : This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: RENT1_HUMAN, Q92900 Function : RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing prematurestop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability Gene Wiki entry for UPF1
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Genomic Viewsfor UPF1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011295.11 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UPF1 gene promoter:Nkx2-5 Other transcription factors Search SABiosciences Chromatin IP Primers for UPF1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.2-p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.2-p13.11 UPF1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P018942: view genomic region
(about GC identifiers )
Start: 18,942,744 bp from pter End:
18,979,039 bp from pter
Size: 36,296 bases Orientation:
plus strand
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Proteinsfor UPF1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RENT1_HUMAN, Q92900 See
protein sequence )Recommended Name: Size : 1129 amino acids; 124345 DaSubunit : Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex(EJC). Associates with the SGM1C complex; is phosphorylated by the complex kinase component SGM1. Interacts with UPF2, UPF3A and UPF3B. Interacts with EST1A and SLBP. Interacts (when hyperphosphorylated) with PNRC2. Interacts with EIF2C1, EIF2C2 and GSPT2. Interacts with isoform 1 and isoform 5 of ADAR/ADAR1
Subcellular location : Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Hyperphosphorylated form is targeted to the P-body,while unphosphorylated protein is distributed throughout the cytoplasm
Sequence caution : Sequence=BAA19664.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;6/8 PDB 3D structures from (see all 8 ):2GJK (3D) 2GK6 (3D) 2GK7 (3D) 2IYK (3D) 2WJV (3D) 2WJY (3D) Secondary accessions : O00239 O43343 Q86Z25 Q92842Alternative splicing : 2 isoforms : Q92900-1 Q92900-2 Explore the universe of human proteins at neXtProt for UPF1: NX_Q92900 Post-translational modifications:
Phosphorylated by SMG1; required for formation of mRNA surveillance complexes1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q92900 4/17 DME Specific Peptides for UPF1 (Q92900 ) (see all 17 )UPF1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_002902.2 ENSEMBL proteins: ENSP00000262803 Reactome Protein details: Q92900 Human Recombinant Protein Products: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing UPF1 Antibody Products: Assay Products for UPF1:
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Protein
Domains /for UPF1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q92900 ProtoNet protein and cluster: Q92900
UniProtKB/Swiss-Prot: RENT1_HUMAN, Q92900 Domain : The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase familySimilarity : Belongs to the DNA2/NAM7 helicase familySimilarity : Contains 1 UPF1-type zinc finger
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Functionfor UPF1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RENT1_HUMAN, Q92900 Function : RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing prematurestop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability Enzyme Numbers (IUBMB): EC 3.6.1 2 EC 3.6.4.- 1
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UPF1 (NM_002911 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UPF1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UPF1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPF1
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing 2 GenomeRNAi human phenotypes for UPF1 :Animal Models: Upf1 tm1Hcd for UPF14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Upf1) :About GeneDecksing
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Pathways & Interactionsfor UPF1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/7 super-pathways (see all 7 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Synthesis of PB1-F2 2 Metabolism of mRNA 3 Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex 4 mRNA surveillance pathway 5 RNA transport
Pathway sources See GeneCards unified pathways Show all pathways 1 5/9 (see all 9 )2 (Kegg details for UPF1) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UPF1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/952 Interacting proteins for UPF1 (Q92900 1 , 2 , 3 ENSP00000262803 4 via UniProtKB, MINT, STRING , and/or I2D (see all 952 )Interactant Interaction Details GeneCard External ID(s) UPF2 Q9HAU5 1 , 2 , 3 ENSP00000348708 4 EBI-373471,EBI-372073 MINT-6539840 MINT-7904432 MINT-6539908 MINT-7904445 MINT-7945693 MINT-7904564 MINT-4791496 MINT-7904530 MINT-6539883 MINT-7904547 MINT-7904417 MINT-7904495 MINT-7904598 MINT-7947479 MINT-6539859 MINT-7904478 MINT-7904581 MINT-7904403 MINT-7904512 MINT-7904458 I2D:
score=9 STRING: ENSP00000348708 GSPT1 P15170 2 , 3 ENSP00000398131 4 MINT-6539771 MINT-6539822 MINT-7945693 MINT-6539753 I2D:
score=1 STRING: ENSP00000398131 ETF1 P62495 2 , 3 ENSP00000353741 4 MINT-7945693 MINT-6539753 MINT-7947479 I2D:
score=3 STRING: ENSP00000353741 TERT O14746 2 , 3 ENSP00000309572 4 MINT-8286561 MINT-8286551 MINT-8286579 I2D:
score=1 STRING: ENSP00000309572 PSMD12 O00232 2 , 3 ENSP00000348442 4 MINT-7945693 MINT-7947479 I2D:
score=5 STRING: ENSP00000348442
About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing
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Drugs & Compoundsfor UPF1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for UPF1 4 Novoseek chemical compound relationships for UPF1 gene About this table UPF1 / RENT1
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Transcriptsfor UPF1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for UPF1 gene: NM_002911.3 Unigene Cluster for UPF1:
UPF1 regulator of nonsense transcripts homolog (yeast) Hs.515266 [show with all ESTs ] Unigene Representative Sequence: NM_002911 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000262803 (uc002nkf.3 uc002nkg.3 uc002nkh.3 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UPF1 (NM_002911 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UPF1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UPF1
Additional cDNA sequence: AF074016.1 AK125797.1 AK128727.1 BC034291.1 BC039817.1 D86988.1 U59323.1 U65533.1
23 DOTS entries : DT.100822434 DT.456245
DT.97802108 DT.100801983 DT.92441421 DT.40289544 DT.121468677 DT.95190426 DT.100822424 DT.100822429 DT.100822431 DT.102828678 DT.121468685 DT.121468688 DT.121468701 DT.121468708 DT.121468718 DT.91947800 DT.91968174 DT.92441407 DT.97801452 DT.100822428 DT.92441406 24/431 AceView cDNA sequences (see all 431 ):
D86988 BM742246 BG288234 BX384942 BU431219 BQ439866 BU727281 BQ271175 BM016503 AA412091 AK125797 AA705513 AW009890 BI050221 CA946823 BF508927 CD364377 BM764737 CR614589 AW272624 BQ950083 BM693677 NM_002911 AI569472 GeneLoc Exon Structure 5/13 Alternative Splicing Database (ASD) splice patterns (SP) for UPF1 (see all 13 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ SP1 : - - - - - - - SP2 : - - - - - - SP3 : SP4 : SP5 :
ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 SP1 : - - - SP2 : - - - SP3 : - - SP4 : - - SP5 :
ECgene alternative splicing isoforms for UPF1
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Expression for UPF1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section UPF1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CACCGGGTAG
About this image See UPF1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UPF1 SOURCE GeneReport for Unigene cluster: Hs.515266 UniProtKB/Swiss-Prot: RENT1_HUMAN, Q92900 Tissue specificity : UbiquitousSABiosciences Custom PCR Arrays for UPF1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPF1
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Orthologsfor UPF1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for UPF1 gene from 9/37 species (see all 37 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Upf11 5
UPF1 regulator of nonsense transcripts homolog (yeast) less 1, 5
88.92(n) 1 98.92(a) 1
8 (34.15 cM) 5 19704 1 NM_001122829.1 1 NP_001116301.1 1 70331522 5
chicken Aves UPF11
UPF1 regulator of nonsense transcripts homolog (yeast) less
81.08(n) 97.87(a)
420119 XM_418237.3 XP_418237.3
African clawed frog Amphibia Xl.105472
Xenopus laevis transcribed sequence with strong similarity to protein spQ92900 (H.sapiens) RNT1_HUMAN Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) less
79.67(n)
BU914294.1
zebrafish Actinopterygii Dr.135942
Danio rerio mRNA similar to regulator of nonsense transcripts 1 (cDNA clone MGC55472 IMAGE2640133), complete cds less
82.95(n)
BC045353.1
fruit fly Insecta Upf11
CG1559-PA
68.46(n) 71.44(a)
32153 NM_132539.2 NP_572767.1
worm Secernentea smg-21
Protein SMG-2
54.6(n) 52.86(a)
171696 NM_058428.3 NP_490829.1
baker's yeast Saccharomycetes NAM7(YMR080C)4 1
ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance less 4 1
53.86(n) 1 56.88(a) 1
13(429627-426712) 4 855104 1, 4 NP_013797.1 1, 4
thale cress eudicotyledons LBA11
Regulator of nonsense transcripts 1-like protein
58.41(n) 63.94(a)
834747 NM_124072.2 NP_199512.2
rice Liliopsida Os.188372
Oryza sativa (japonica cultivar-group) cDNA cloneJ023105F12, full insert sequence less
72.8(n)
AK067729.1
ENSEMBL Gene Tree for UPF1 (if available)TreeFam Gene Tree for UPF1 (if available)
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Paralogsfor UPF1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for UPF1 gene ZNFX1 2 AQR 2 C4orf21 2 About GeneDecksing
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Genomic Variantsfor UPF1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 19 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for UPF1 (18942744 - 18979039 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for UPF1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor UPF1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601430
OMIM disorders : --13 : About MalaCards ullrich congenital muscular dystrophy amyotrophic lateral sclerosis (als) amyotrophic lateral sclerosis congenital muscular dystrophy long qt syndrome muscular dystrophy lateral sclerosis colon cancer gastric cancer colorectal cancer prostate cancer prostatitis malaria 1 disease from the University of Copenhagen DISEASES database for UPF1 :Ullrich congenital muscular dystrophy Export disorders for UPF1 gene to outside databases
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Publicationsfor UPF1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for UPF1 gene, integrated from 9 sources (see all 124 ):(articles sorted by number of sources associating them with UPF1) Utopia : connect your pdf to the dynamic
Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. (PubMed id 9064659) 1 , 2 , 3, 9(1997) Mammalian orthologues of a yeast regulator of nonsense transcript stability. (PubMed id 8855285) 1 , 2 , 3, 9(1996) Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. (PubMed id 12554878) 1 , 2 , 9(2003) Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. (PubMed id 16452507) 1 , 2 , 9(2006) SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. (PubMed id 15721257) 1 , 2 , 9(2005) SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PubMed id 19417104) 1 , 2 , 9(2009) Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. (PubMed id 10999600) 1 , 2 , 9(2000) Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PubMed id 19150429) 1 , 2 , 9(2009) Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. (PubMed id 16086026) 1 , 2 , 9(2005) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. (PubMed id 11331269) 1 , 2 , 9(2001)
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External Searches for UPF1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing UPF1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing UPF1 gene
(According to HUGE )
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Specialized Databases showing UPF1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for UPF1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for UPF1 gene: UPF1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor UPF1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for UPF1 OriGene shRNA RFP for UPF1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for UPF1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for UPF1 OriGene 3'-UTR Clone for UPF1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for UPF1 OriGene Custom Protein Services for UPF1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UPF1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for UPF1 (RENT1)
Search Tocris compounds for UPF1
UPF1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPF1
ThermoFisher Antibodies for UPF1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UPF1
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