UPB1 Gene
protein-coding GIFtS: 61
GCID: GC22P024891
|
|
ureidopropionase, beta
| |
Aliases
for UPB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ureidopropionase, Beta1 2 | | BUP-12 3 | | BUP11 2 3 5 | | EC 3.5.1.63 8 | | Beta-Alanine Synthase2 3 | | Beta-Ureidopropionase1 | | N-Carbamoyl-Beta-Alanine Amidohydrolase2 3 | | |
Export aliases for UPB1 gene to outside databasesPrevious GC identifers: GC22P021587 GC22P023187 GC22P023215 GC22P023221 GC22P007840 |
Summaries
for UPB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UPB1:
This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step inthe pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action ofdihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine andbeta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and maylead to abnormalities in neurological activity. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BUP1_HUMAN, Q9UBR1Function: Converts N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to, respectively,beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide
Gene Wiki entry for UPB1
|
Genomic Views
for UPB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UPB1 gene promoter:
HOXA9B HOXA9 p53 Nkx2-5 Tal-1beta HEN1 MEF-2A Cart-1 aMEF-2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for UPB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UPB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.2 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.2UPB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P024891: view genomic region
(about GC identifiers)
Start:
|
24,863,206 bp from pter |
End:
|
24,924,358 bp from pter |
Size:
|
61,153 bases |
Orientation:
|
plus strand |
|
Proteins
for UPB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BUP1_HUMAN, Q9UBR1 (See
protein sequence)Recommended Name: Beta-ureidopropionase Size: 384 amino acids; 43166 Da
Cofactor: Binds 1 zinc ion per subunit (Probable)
Subcellular location: Cytoplasm
Secondary accessions: A3KMF8 Q9UIR3Explore the universe of human proteins at neXtProt for UPB1: NX_Q9UBR1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBR1
4 DME Specific Peptides for UPB1 (Q9UBR1)
UPB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057411.1
ENSEMBL proteins: ENSP00000400684 ENSP00000324343 ENSP00000372208 ENSP00000406057 Reactome Protein details: Q9UBR1
Human Recombinant Protein Products for UPB1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
UPB1 for ontologies About GeneDecksing
UPB1 Antibody Products:
Assay Products for UPB1: |
Protein
Domains /
Families
for UPB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UPB1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UBR1ProtoNet protein and cluster: Q9UBR1 1 Blocks protein family: IPB003010 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase
UniProtKB/Swiss-Prot: BUP1_HUMAN, Q9UBR1Similarity: Belongs to the CN hydrolase family. BUP subfamilySimilarity: Contains 1 CN hydrolase domain |
Function
for UPB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: BUP1_HUMAN, Q9UBR1Function: Converts N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to, respectively,beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxideCatalytic activity: N-carbamoyl-beta-alanine + H(2)O = beta-alanine + CO(2) + NH(3)Enzyme regulation: Allosteric enzyme with positive cooperativity toward the substrate N-carbamoyl-beta-alanine (Bysimilarity) Enzyme Number (IUBMB): EC 3.5.1.61 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003837 | beta-ureidopropionase activity |
EXP | -- | | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
-- | -- | | GO:0046872 | metal ion binding |
IEA | -- |
UPB1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for UPB1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UPB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UPB1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UPB1 (NM_016327) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UPB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPB1 |
|
Pathways & Interactions
for UPB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Beta-alanine metabolism | | | 2 | Pyrimidine metabolism | | | 3 | Metabolism | | | 4 | Fluoropyrimidine Activity | | | 5 | beta-Alanine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for UPB1
1  GeneGo (Thomson Reuters) Pathway for UPB1
3  BioSystems Pathways for UPB1
4 
Reactome Pathways for UPB1
1  PharmGKB Pathway for UPB1
5 
Kegg Pathways (Kegg details for UPB1):
UniProtKB/Swiss-Prot: BUP1_HUMAN, Q9UBR1Pathway: Amino-acid biosynthesis; beta-alanine biosynthesis
UPB1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UPB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/17 Interacting proteins for UPB1 (Q9UBR13 ENSP000003243434) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006206 | pyrimidine nucleobase metabolic process |
TAS | -- | | GO:0006807 | nitrogen compound metabolic process |
-- | -- | | GO:0019483 | beta-alanine biosynthetic process |
IEA | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- | | GO:0046135 | pyrimidine nucleoside catabolic process |
TAS | -- |
UPB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UPB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UPB1 for compounds About GeneDecksing
 Browse Tocris compounds for UPB1
7 HMDB Compounds for UPB1 About this table
6 Novoseek chemical compound relationships for UPB1 gene About this table
Search CenterWatch for drugs/clinical trials and news about UPB1 / BUP1
|
Transcripts
for UPB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UPB1 gene: NM_016327.2 Unigene Cluster for UPB1: Ureidopropionase, beta Hs.731656 [show with all ESTs]Unigene Representative Sequence: CR6274296 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000415388(uc003aaf.3) ENST00000326010 ENST00000382760 ENST00000498140(uc021wnh.1)
ENST00000486043 ENST00000413389(uc003aae.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UPB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UPB1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UPB1 (NM_016327) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UPB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPB1 |
Additional cDNA sequence: AB013885.1 AF163312.1 AK024277.1 AK314727.1 BC033388.1 BC131703.1 BC139840.1 BC139843.1 BX537493.1 CR456375.1 CR627429.1 8 DOTS entries: DT.75100808 DT.40126701 DT.97836899 DT.100752498 DT.95216645 DT.95263143 DT.40246735 DT.91703194 24/75 AceView cDNA sequences (see all 75): BF476557 F02979 AB013885 AW237260 BX281661 AW001678 BC033388 AW271340 NM_016327 AF163312 H55374 AV681862 H55419 AV647795 AV718545 CR456375 AV720239 AV654966 CB163933 AV650334 AV654404 AV699567 H11714 AI470928
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for UPB1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UPB1
|
Expression
for UPB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UPB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTAGCCAGC
About this image
See UPB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UPB1
SOURCE GeneReport for Unigene cluster: Hs.731656
SABiosciences Custom PCR Arrays for UPB1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UPB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UPB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UPB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UPB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPB1 |
Orthologs
for UPB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UPB1 gene from 8/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
UPB11 |
ureidopropionase, beta |
73.54(n)
79.63(a) |
|
416949 XM_415242.3 XP_415242.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UPB16 |
-- |
76(a) |
1 ↔ 1 |
GL343947.1(70323-75297) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
CF589848.12 |
-- |
72.32(n) |
|
CF589848.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb69e032 |
wufb69e03 |
82.26(n) |
|
322660 BC053204.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
pyd31 , 3 |
beta-ureidopropionase3
CG3027-PA1 |
63(a)3
62.07(n)1
64.06(a)1 |
|
84D143
409161 NM_141475.21 NP_649732.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F13H8.73
upb-11 |
beta-ureidopropionase (rat)3
Protein UPB-11 |
62(a)3
60.4(n)1
62.14(a)1 |
|
II(6288461-6290041)3
1740401 NM_062860.21 NP_495261.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
BETA-UP1 |
beta-ureidopropionase |
58.18(n)
60.74(a) |
|
836558 NM_125833.4 NP_201242.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.80242 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
73.27(n) |
|
AK060443.1 |
ENSEMBL Gene Tree for UPB1 (if available)
TreeFam Gene Tree for UPB1 (if available) |
Paralogs
for UPB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UPB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UPB1 (24863206 - 24924358 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UPB1
1 CNV: 31081
Human Gene Mutation Database (HGMD): UPB1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UPB1 |
|
Disorders
/ Diseases
for UPB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UPB1 for disorders About GeneDecksing
OMIM gene information: 606673
OMIM disorders: 613161
UniProtKB/Swiss-Prot: BUP1_HUMAN, Q9UBR1
Defects in UPB1 are the cause of beta-ureidopropionase deficiency (BUPD) [MIM:613161]. It is characterized bymuscular hypotonia, dystonic movements, scoliosis, microcephaly and severe developmental delay. Patients show stronglyelevated levels of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyric acid in plasma, cerebrospinal fluid andurine
8  diseases for UPB1: About MalaCardsbeta-ureidopropionase deficiency ornithine carbamoyltransferase deficiency propionic acidemia partial optic atrophy
optic atrophy scoliosis microcephaly hypotonia
2 Novoseek disease relationships for UPB1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| enzyme deficiency |
57.8 |
1 |
17065070 (1) |
| hyperammonemia |
54.8 |
1 |
17467347 (1) |
Human Genome Epidemiology (HuGE) Navigator: UPB1 (5 documents)
Export disorders for UPB1 gene to outside databases
|
Publications
for UPB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UPB1 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with UPB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning, genomic structure and chromosomal localization of the human BUP-1 gene encoding beta-ureidopropionase. (PubMed id 10542323)1, 2, 3, 9 Vreken P....van Gennip A.H. (1999)
- Beta-ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities. (PubMed id 15385443)1, 2, 9 van Kuilenburg A.B.P.... van Gennip A.H. (2004)
- Expression and properties of human liver beta-ureidopropionase. (PubMed id 11508704)1, 2, 9 Sakamoto T.... Tamaki N. (2001)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism. (PubMed id 18216719)1, 9 Thomas H.R....Diasio R.B. (2008)
- Genetic analysis of the first 4 patients with beta-ureidopropionase deficiency. (PubMed id 17065070)1, 9 van Kuilenburg A.B....van Gennip A.H. (2006)
- Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. (PubMed id 18075467)1, 9 Thomas H.R....Diasio R.B. (2007)
- beta-Ureidopropionase deficiency: a novel inborn error of metabolism discovered using NMR spectroscopy on urine. (PubMed id 11675655)6, 9 Moolenaar S.H....Wevers R.A. (2001)
- s-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients. (PubMed id 22525402)1 van Kuilenburg A.B....Hennekam R.C. (2012)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
|
External Searches for UPB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UPB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UPB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UPB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UPB1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/UPB1 |
|
| | |
About This Section
| Patent Information for UPB1 gene:
Search GeneIP for patents involving UPB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UPB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UPB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UPB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UPB1 | | | OriGene Protein Over-expression Lysate for UPB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UPB1 | | OriGene 3'-UTR Clone for UPB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UPB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UPB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UPB1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UPB1 | | OriGene Custom Protein Services for UPB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UPB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UPB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UPB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UPB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UPB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UPB1 |
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| | | | Search Tocris compounds for UPB1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UPB1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for UPB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UPB1 |
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