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Aliases for UOX Gene

Aliases for UOX Gene

  • Urate Oxidase (Pseudogene) 2 3 5
  • Urate Oxidase 2
  • URICASE 3
  • UOXP 3

External Ids for UOX Gene

Previous GeneCards Identifiers for UOX Gene

  • GC01U990181
  • GC01M084602
  • GC01M084830
  • GC01M082940

Summaries for UOX Gene

Entrez Gene Summary for UOX Gene

  • Urate oxidase is an enzyme that catalyzes the oxidation of uric acid to allantoin. This gene has been inactivated by mutation and is nonfunctional in humans and some other primates. [provided by RefSeq, Jul 2008]

GeneCards Summary for UOX Gene

UOX (Urate Oxidase (Pseudogene)) is a Pseudogene.

Gene Wiki entry for UOX Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UOX Gene

Genomics for UOX Gene

Regulatory Elements for UOX Gene

Enhancers for UOX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F084364 1.2 Ensembl ENCODE 11 +31.8 31758 2.9 PKNOX1 ATF1 INSM2 KLF17 FEZF1 RAD21 ZEB1 RFX5 ZNF366 RCOR1 UOX DNASE2B RPF1 GC01M084160
GH01F084298 1.1 ENCODE 10.1 +96.8 96818 6.8 HDGF ATF1 ARNT CREB3L1 SIN3A FEZF1 ZNF48 ZNF2 YY1 GLIS2 RPF1 SYDE2 LOC105378818 BCL10 MCOLN3 DNASE2B UOX SAMD13 ENSG00000199959 ENSG00000249237
GH01F084432 1 Ensembl ENCODE 11.1 -37.6 -37634 5.3 CTCF PKNOX1 ZNF384 RAD21 ZNF101 RFX5 SCRT2 ZNF143 SMC3 TCF7L2 DNASE2B SPATA1 GNG5 UOX SAMD13 RPF1 ENSG00000199959 GC01M084333
GH01F084427 0.9 ENCODE 11.3 -30.0 -30012 0.6 KLF17 GLIS2 SCRT2 KLF7 FOS EGR2 SP3 ZBTB11 ZEB2 CBX8 DNASE2B UOX GC01M084333
GH01F084270 1 Ensembl ENCODE 9.8 +125.7 125728 3.2 KLF1 PKNOX1 TEAD4 TBX21 GABPA CBX5 POLR2A EED IKZF1 MLLT1 DNASE2B UOX RPF1 SYDE2 SAMD13 GC01P084245
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UOX on UCSC Golden Path with GeneCards custom track

Genomic Location for UOX Gene

Chromosome:
1
Start:
84,364,958 bp from pter
End:
84,397,893 bp from pter
Size:
32,936 bases
Orientation:
Minus strand

Genomic View for UOX Gene

Genes around UOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UOX Gene

Proteins for UOX Gene

Post-translational modifications for UOX Gene

No Post-translational modifications

No data available for DME Specific Peptides for UOX Gene

Domains & Families for UOX Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for UOX Gene

Function for UOX Gene

Molecular function for UOX Gene

GENATLAS Biochemistry:
urate-oxidase,rat sequence homolog (not expressed in humans)

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UOX Gene

Localization for UOX Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for UOX Gene

Pathways & Interactions for UOX Gene

No Data Available

Interacting Proteins for UOX Gene

Gene Ontology (GO) - Biological Process for UOX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UOX Gene

Transcripts for UOX Gene

mRNA/cDNA for UOX Gene

(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UOX Gene

Urate oxidase, pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UOX Gene

No ASD Table

Relevant External Links for UOX Gene

GeneLoc Exon Structure for
UOX
ECgene alternative splicing isoforms for
UOX

Expression for UOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UOX Gene

mRNA differential expression in normal tissues according to GTEx for UOX Gene

This gene is overexpressed in Testis (x12.4) and Brain - Caudate (basal ganglia) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of UOX Gene:

UOX

SOURCE GeneReport for Unigene cluster for UOX Gene:

Hs.647646
genes like me logo Genes that share expression patterns with UOX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for UOX Gene

Orthologs for UOX Gene

Evolution for UOX Gene

ENSEMBL:
Gene Tree for UOX (if available)
TreeFam:
Gene Tree for UOX (if available)

No data available for Orthologs for UOX Gene

Paralogs for UOX Gene

No data available for Paralogs for UOX Gene

Variants for UOX Gene

Sequence variations from dbSNP and Humsavar for UOX Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10493748 -- 84,374,048(-) AGAGT(G/T)TTGAG intron-variant
rs10591827 -- 84,370,245(+) ACACA(-/CACA)TACAC intron-variant
rs10711764 -- 84,383,563(+) CAAGT(-/A)AAAAA intron-variant
rs111590975 -- 84,365,022(+) AAACA(A/G)TATTT nc-transcript-variant
rs111611942 -- 84,371,413(+) ATTCC(C/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UOX Gene

Variant ID Type Subtype PubMed ID
esv2677432 CNV deletion 23128226
esv3577990 CNV loss 25503493
nsv1744 CNV insertion 18451855
nsv830426 CNV gain 17160897
nsv830437 CNV gain+loss 17160897

Relevant External Links for UOX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for UOX Gene

Disorders for UOX Gene

Relevant External Links for UOX

Genetic Association Database (GAD)
UOX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UOX

No disorders were found for UOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UOX Gene

Publications for UOX Gene

  1. Localization of the human urate oxidase gene (UOX) to 1p22. (PMID: 1395718) Yeldandi A.V. … Le Beau M.M. (Cytogenet. Cell Genet. 1992) 2 3 64
  2. Two independent mutational events in the loss of urate oxidase during hominoid evolution. (PMID: 1556746) Wu X.W. … Caskey C.T. (J. Mol. Evol. 1992) 2 3 64
  3. Evolutionary history and metabolic insights of ancient mammalian uricases. (PMID: 24550457) Kratzer J.T. … Gaucher E.A. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  4. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PMID: 22095909) Lange C.M. … Bochud P.Y. (Hepatology 2012) 3 64
  5. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 3 64

Products for UOX Gene

Sources for UOX Gene

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