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urate oxidase, pseudogene(Previous name: urate oxidase )
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Aliases
for UOX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 8
| Aliases |
|---|
| Urate Oxidase, Pseudogene1 2 | | UOXP1 2 | | Urate Oxidase1 | | URICASE2 |
| External Ids: | HGNC: 125751 | Entrez Gene: 3910512 | Ensembl: ENSG000002405207 | OMIM: 1915405 | | ORGUL members: | |
|---|
| NONCODE:n363307 n364140 | |
Export aliases for UOX gene to outside databasesPrevious GC identifers: GC01U990181 GC01M084602 GC01M082940
|---|
Summaries
for UOX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UOX:
Urate oxidase is an enzyme that catalyzes the oxidation of uric acid to allantoin. This gene has been inactivated bymutation and is nonfunctional in humans and some other primates. (provided by RefSeq, Jul 2008)
Gene Wiki entry for UOX (Urate oxidase)
|
Genomic Views
for UOX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UOX gene promoter:
STAT5B Sox5 AML1a NRSF form 1 IRF-1 NRSF form 2 C/EBPalpha E47 Hand1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for UOX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UOX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.1UOX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M084830: view genomic region
(about GC identifiers)
Start:
|
84,830,641 bp from pter |
End:
|
84,863,576 bp from pter |
Size:
|
32,936 bases |
Orientation:
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minus strand |
ORGUL member locations:
Legend (see complete legend)
84830647 84847112 84863576 chr1
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Proteins
for UOX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for UOX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for UOX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for UOX:urate-oxidase,rat sequence homolog (not expressed in humans)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UOX |
Animal Models:
Mouse knock-out Uoxtm1Bay for UOX
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Uox):
UOX for phenotypes About GeneDecksing
|
Pathways & Interactions
for UOX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UOX
|
Drugs & Compounds
for UOX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UOX
Search CenterWatch for drugs/clinical trials and news about UOX 
|
Transcripts
for UOX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for UOX: Urate oxidase, pseudogene Hs.647646 [show with all ESTs]Unigene Representative Sequence: NR_0039272 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471089(uc009wcg.3) ENST00000483236
Additional cDNA sequence: NR_003927.1 2 DOTS entries: DT.121454614 DT.75136422 6 AceView cDNA sequences: BQ271106 BQ271399 AI208826 BG217060 BG185251 BG187340
GeneLoc Exon Structure
|
Expression
for UOX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UOX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.647646
SABiosciences Custom PCR Arrays for UOX
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UOX
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat UOX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UOX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UOX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UOX |
Orthologs
for UOX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for UOX gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Uox5 |
urate oxidase |
-- |
|
3 (72.09 cM) 146597077 |
ENSEMBL Gene Tree for UOX (if available)
TreeFam Gene Tree for UOX (if available) |
Paralogs
for UOX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UOX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UOX (84830641 - 84863576 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UOX: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for UOX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UOX for disorders About GeneDecksing
OMIM gene information: 191540
OMIM disorders: --
1  disease for UOX: About MalaCardsurate oxidase deficiency
Export disorders for UOX gene to outside databases
|
Publications
for UOX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UOX gene integrated from 9 sources:
(articles sorted by number of sources associating them with UOX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Localization of the human urate oxidase gene (UOX) to 1p22. (PubMed id 1395718)1, 3 Yeldandi A.V....Le Beau M.M. (1992)
- Two independent mutational events in the loss of urat e oxidase during hominoid evolution. (PubMed id 1556746)1, 3 Wu X.W....Caskey C.T. (1992)
- Identification and analysis of unitary pseudogenes: h istoric and contemporary gene losses in humans and other primates. (PubMed id 20210993)1 Zhang Z.D....Gerstein M. (2010)
- Comparative genomics search for losses of long-established genes on the human lineage. (PubMed id 18085818)1 Zhu J....Haussler D. (2007)
- Loss of urate oxidase activity in hominoids and its evolutionary implications. (PubMed id 11961098)1 Oda M....Takahata N. (2002)
- Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase. (PubMed id 11700027)1 Shiokawa D. and Tanuma S. (2001)
- Human urate oxidase gene: cloning and partial sequence analysis reveal a stop codon within the fifth exon. (PubMed id 2403354)1 Yeldandi A.V....Reddy J.K. (1990)
|
External Searches for UOX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UOX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UOX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UOX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UOX | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UOX gene:
Search GeneIP for patents involving UOX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UOX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UOX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UOX | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | Browse OriGene untagged cDNA clones in CMV expression vector | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UOX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UOX | | OriGene Custom Protein Services for UOX | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UOX | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UOX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UOX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UOX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UOX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UOX |
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 |  |  |  | |
| | | | Search Tocris compounds for UOX |
| |  |  |  |  | | | | | | Recombinant Protein for UOX |
|
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 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UOX |
|  |  |  | | | | Search ThermoFisher Antibodies for UOX |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UOX |
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