Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UOX Gene

Aliases for UOX Gene

  • Urate Oxidase, Pseudogene 2 3
  • Urate Oxidase 2
  • UOXP 3

External Ids for UOX Gene

Previous GeneCards Identifiers for UOX Gene

  • GC01U990181
  • GC01M084602
  • GC01M084830
  • GC01M082940

Summaries for UOX Gene

Entrez Gene Summary for UOX Gene

  • Urate oxidase is an enzyme that catalyzes the oxidation of uric acid to allantoin. This gene has been inactivated by mutation and is nonfunctional in humans and some other primates. [provided by RefSeq, Jul 2008]

GeneCards Summary for UOX Gene

UOX (Urate Oxidase, Pseudogene) is a Pseudogene.

Gene Wiki entry for UOX Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UOX Gene

Genomics for UOX Gene

Regulatory Elements for UOX Gene

Genomic Location for UOX Gene

84,364,958 bp from pter
84,397,893 bp from pter
32,936 bases
Minus strand

Genomic View for UOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UOX Gene

Proteins for UOX Gene

Post-translational modifications for UOX Gene

No Post-translational modifications

No data available for DME Specific Peptides for UOX Gene

Domains for UOX Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for UOX Gene

Function for UOX Gene

Molecular function for UOX Gene

GENATLAS Biochemistry:
urate-oxidase,rat sequence homolog (not expressed in humans)
genes like me logo Genes that share phenotypes with UOX: view

Animal Models for UOX Gene

MGI Knock Outs for UOX:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for UOX Gene

Localization for UOX Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for UOX Gene

Pathways for UOX Gene

SuperPathways for UOX Gene

No Data Available

Interacting Proteins for UOX Gene

Gene Ontology (GO) - Biological Process for UOX Gene


No data available for Pathways by source for UOX Gene

Transcripts for UOX Gene

mRNA/cDNA for UOX Gene

(6) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UOX Gene

Urate oxidase, pseudogene:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UOX

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UOX Gene

No ASD Table

Relevant External Links for UOX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UOX Gene

mRNA expression in normal human tissues for UOX Gene

mRNA differential expression in normal tissues according to GTEx for UOX Gene

This gene is overexpressed in Testis (12.4) and Brain - Caudate (basal ganglia) (4.2).

SOURCE GeneReport for Unigene cluster for UOX Gene Hs.647646

genes like me logo Genes that share expressions with UOX: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for UOX Gene

Orthologs for UOX Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for UOX Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Uox 16
Species with no ortholog for UOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UOX Gene

Gene Tree for UOX (if available)
Gene Tree for UOX (if available)

Paralogs for UOX Gene

No data available for Paralogs for UOX Gene

Variants for UOX Gene

Sequence variations from dbSNP and Humsavar for UOX Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs315511 -- 84,383,433(-) TCCTA(A/T)TTTTA intron-variant
rs315512 -- 84,382,695(-) CTCTA(A/G)TAAAA intron-variant
rs315513 -- 84,382,345(-) CTGGA(A/G)TCTCC intron-variant
rs315514 -- 84,380,341(-) aatat(A/G)atgca intron-variant
rs315515 -- 84,379,685(-) CAAAG(A/G)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UOX Gene

Variant ID Type Subtype PubMed ID
nsv830426 CNV Gain 17160897
nsv1744 CNV Insertion 18451855
esv2677432 CNV Deletion 23128226
nsv830437 CNV Gain+Loss 17160897

Relevant External Links for UOX Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UOX Gene

Disorders for UOX Gene

Relevant External Links for UOX

Genetic Association Database (GAD)

No disorders were found for UOX Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for UOX Gene

Publications for UOX Gene

  1. Localization of the human urate oxidase gene (UOX) to 1p22. (PMID: 1395718) Yeldandi A.V. … Le Beau M.M. (Cytogenet. Cell Genet. 1992) 2 3
  2. Two independent mutational events in the loss of urate oxidase during hominoid evolution. (PMID: 1556746) Wu X.W. … Caskey C.T. (J. Mol. Evol. 1992) 2 3
  3. Human urate oxidase gene: cloning and partial sequence analysis reveal a stop codon within the fifth exon. (PMID: 2403354) Yeldandi A.V. … Reddy J.K. (Biochem. Biophys. Res. Commun. 1990) 3
  4. Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase. (PMID: 11700027) Shiokawa D. … Tanuma S. (Biochem. Biophys. Res. Commun. 2001) 3
  5. Loss of urate oxidase activity in hominoids and its evolutionary implications. (PMID: 11961098) Oda M. … Takahata N. (Mol. Biol. Evol. 2002) 3

Products for UOX Gene

Sources for UOX Gene

Back to Top