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Aliases for UNKL Gene

Aliases for UNKL Gene

  • Unkempt Family Like Zinc Finger 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 5-Like 3 4
  • RING Finger Protein Unkempt-Like 3 4
  • Unkempt Family Zinc Finger-Like 2 3
  • C16orf28 3 4
  • ZC3HDC5L 3 4
  • ZC3H5L 3 4
  • Putative E3 Ubiquitin-Protein Ligase UNKL 3
  • Chromosome 16 Open Reading Frame 28 2
  • Unkempt Homolog (Drosophila)-Like 2
  • Unkempt Homolog-Like 3
  • EC 2.3.2.- 4

External Ids for UNKL Gene

Previous HGNC Symbols for UNKL Gene

  • C16orf28

Previous GeneCards Identifiers for UNKL Gene

  • GC16M001449
  • GC16M001373
  • GC16M001358
  • GC16M001414
  • GC16M001343
  • GC16M001418
  • GC16M001419
  • GC16M001420
  • GC16M001422
  • GC16M001427
  • GC16M001428
  • GC16M001432

Summaries for UNKL Gene

Entrez Gene Summary for UNKL Gene

  • This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for UNKL Gene

UNKL (Unkempt Family Like Zinc Finger) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. GO annotations related to this gene include ligase activity. An important paralog of this gene is UNK.

UniProtKB/Swiss-Prot for UNKL Gene

  • May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.

Gene Wiki entry for UNKL Gene

Additional gene information for UNKL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNKL Gene

Genomics for UNKL Gene

Regulatory Elements for UNKL Gene

Enhancers for UNKL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001308 1.4 ENCODE dbSUPER 112.8 +104.0 103997 5.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H001271 1.1 ENCODE 108.9 +142.9 142925 1.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
GH16H002147 2 FANTOM5 Ensembl ENCODE dbSUPER 50.2 -741.0 -741040 17.4 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC CRAMP1 ENSG00000260051 ENSG00000261505 TELO2 TBL3 UNKL E4F1 TSC2 SRRM2 ZNF213-AS1
GH16H001962 1.4 Ensembl ENCODE 50.6 -549.5 -549471 4.1 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ENSG00000255513 ENSG00000261505 ENSG00000260051 TELO2 E4F1 UNKL TSC2 SNHG9 CRAMP1 SRRM2
GH16H000981 1.2 ENCODE dbSUPER 53.5 +433.3 433276 0.2 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 KLF7 ZNF548 SP3 MCM3 WDR90 CRAMP1 ENSG00000261505 UBE2I JMJD8 TELO2 ENSG00000260954 UNKL ENSG00000260051 WDR24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UNKL on UCSC Golden Path with GeneCards custom track

Promoters for UNKL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for UNKL Gene

Genomic Locations for UNKL Gene
51,547 bases
Minus strand

Genomic View for UNKL Gene

Genes around UNKL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNKL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNKL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNKL Gene

Proteins for UNKL Gene

  • Protein details for UNKL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative E3 ubiquitin-protein ligase UNKL
    Protein Accession:
    Secondary Accessions:
    • B0QYN6
    • B1GXI8
    • Q96EV1
    • Q96RZ1
    • Q9BWL5
    • Q9H5K0
    • Q9UJJ8

    Protein attributes for UNKL Gene

    680 amino acids
    Molecular mass:
    73828 Da
    Quaternary structure:
    • Isoform 4 (C-terminal) interacts with the GTP-bound form of RAC1. Isoform 4 (C-terminal) interacts with SMARCD2/BAF60b.

    Alternative splice isoforms for UNKL Gene

neXtProt entry for UNKL Gene

Post-translational modifications for UNKL Gene

  • Isoform 4 is ubiquitinated in the C-terminal. Ubiquitination is enhanced by activated RAC1. The presence of the RING finger domain is not essential for ubiquitination to occur.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UNKL Gene

Domains & Families for UNKL Gene

Gene Families for UNKL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UNKL Gene


Suggested Antigen Peptide Sequences for UNKL Gene

Graphical View of Domain Structure for InterPro Entry



  • Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven.
  • Belongs to the unkempt family.
  • Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven.
  • Belongs to the unkempt family.
genes like me logo Genes that share domains with UNKL: view

Function for UNKL Gene

Molecular function for UNKL Gene

UniProtKB/Swiss-Prot Function:
May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.

Enzyme Numbers (IUBMB) for UNKL Gene

Phenotypes From GWAS Catalog for UNKL Gene

Gene Ontology (GO) - Molecular Function for UNKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 20148946
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with UNKL: view
genes like me logo Genes that share phenotypes with UNKL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNKL Gene

Localization for UNKL Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNKL Gene

Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNKL gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UNKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with UNKL: view

Pathways & Interactions for UNKL Gene

genes like me logo Genes that share pathways with UNKL: view

UniProtKB/Swiss-Prot Q9H9P5-UNKL_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UNKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with UNKL: view

No data available for SIGNOR curated interactions for UNKL Gene

Drugs & Compounds for UNKL Gene

No Compound Related Data Available

Transcripts for UNKL Gene

Unigene Clusters for UNKL Gene

Unkempt homolog (Drosophila)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNKL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: -
SP3: - -
SP4: -
SP5: - - -

Relevant External Links for UNKL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNKL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNKL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNKL Gene

This gene is overexpressed in Placenta (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UNKL Gene

Protein tissue co-expression partners for UNKL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNKL Gene:


SOURCE GeneReport for Unigene cluster for UNKL Gene:


Evidence on tissue expression from TISSUES for UNKL Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with UNKL: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNKL Gene

Orthologs for UNKL Gene

This gene was present in the common ancestor of animals.

Orthologs for UNKL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UNKL 33 34
  • 82.84 (n)
(Mus musculus)
Mammalia Unkl 33 16 34
  • 82.84 (n)
Gm5819 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Unkl 33
  • 82.74 (n)
(Canis familiaris)
Mammalia UNKL 33 34
  • 82.02 (n)
(Monodelphis domestica)
Mammalia UNKL 34
  • 57 (a)
(Pan troglodytes)
Mammalia UNKL 34
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia UNKL 34
  • 47 (a)
(Gallus gallus)
Aves UNKL 33 34
  • 70.2 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia unkl 33
  • 66.67 (n)
(Danio rerio)
Actinopterygii unkl 33
  • 65.1 (n)
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10310 33
fruit fly
(Drosophila melanogaster)
Insecta unk 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea C34D10.2 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for UNKL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNKL Gene

Gene Tree for UNKL (if available)
Gene Tree for UNKL (if available)

Paralogs for UNKL Gene

Paralogs for UNKL Gene

(1) SIMAP similar genes for UNKL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UNKL: view

Variants for UNKL Gene

Sequence variations from dbSNP and Humsavar for UNKL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs193302860 Pathogenic 1,363,030(+) CGAGA(C/T)GCCCA downstream-variant-500B, reference, missense
rs7192408 Likely benign 1,363,315(+) AACTT(C/T)AAACA nc-transcript-variant, utr-variant-3-prime
rs189677035 Uncertain significance 1,363,118(+) GTGGA(C/T)GCGGC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs201263537 Uncertain significance 1,362,747(+) GGTAC(A/C/T)GTATT intron-variant, downstream-variant-500B
rs202080062 Uncertain significance 1,362,714(+) CTTGG(A/G)GTTTG downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UNKL Gene

Variant ID Type Subtype PubMed ID
dgv1286n106 CNV deletion 24896259
dgv2692n100 CNV gain 25217958
dgv322e201 CNV deletion 23290073
dgv473e214 CNV loss 21293372
dgv4850n54 CNV loss 21841781
dgv4851n54 CNV loss 21841781
dgv4852n54 CNV gain+loss 21841781
dgv4853n54 CNV loss 21841781
esv1002378 CNV gain 20482838
esv1006152 CNV deletion 20482838
esv1007015 CNV deletion 20482838
esv1590891 CNV deletion 17803354
esv2422427 CNV duplication 17116639
esv24901 CNV gain 19812545
esv2606593 CNV deletion 19546169
esv2750334 CNV deletion 23290073
nsv952899 CNV deletion 24416366
nsv827493 CNV gain 20364138
nsv819844 CNV gain 19587683
nsv819318 CNV loss 19587683
nsv819259 CNV gain 19587683
nsv571160 CNV loss 21841781
nsv571144 CNV gain 21841781
nsv512419 CNV loss 21212237
nsv471066 CNV loss 18288195
nsv457331 CNV loss 19166990
nsv428316 CNV gain+loss 18775914
nsv1143801 CNV deletion 24896259
nsv1138406 CNV deletion 24896259
nsv1130693 CNV deletion 24896259
nsv1071249 CNV deletion 25765185
nsv1069897 CNV deletion 25765185
nsv1069896 CNV deletion 25765185
nsv1046314 CNV loss 25217958
esv8940 CNV loss 19470904
esv3637616 CNV gain 21293372
esv3552993 CNV deletion 23714750
esv3208235 CNV deletion 24192839
esv2914 CNV loss 18987735
esv2762143 CNV gain 21179565
esv2750342 CNV deletion 23290073
esv2750341 CNV deletion 23290073
esv2750339 CNV deletion 23290073
esv2750338 CNV deletion 23290073
esv2750336 CNV deletion 23290073

Variation tolerance for UNKL Gene

Gene Damage Index Score: 2.91; 48.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNKL Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNKL Gene

Disorders for UNKL Gene

Relevant External Links for UNKL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UNKL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNKL Gene

Publications for UNKL Gene

  1. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. (PMID: 20148946) Lorès P … Gacon G (The FEBS journal 2010) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 60
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60

Products for UNKL Gene

Sources for UNKL Gene

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