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Aliases for UNKL Gene

Aliases for UNKL Gene

  • Unkempt Family Zinc Finger-Like 2 3
  • Zinc Finger CCCH Domain-Containing Protein 5-Like 3 4
  • RING Finger Protein Unkempt-Like 3 4
  • C16orf28 3 4
  • ZC3HDC5L 3 4
  • ZC3H5L 3 4
  • Chromosome 16 Open Reading Frame 28 2
  • Unkempt Homolog (Drosophila)-Like 2
  • Unkempt Homolog-Like 3
  • EC 6.3.2.- 4

External Ids for UNKL Gene

Previous HGNC Symbols for UNKL Gene

  • C16orf28

Previous GeneCards Identifiers for UNKL Gene

  • GC16M001449
  • GC16M001373
  • GC16M001358
  • GC16M001414
  • GC16M001343
  • GC16M001418
  • GC16M001419
  • GC16M001420
  • GC16M001422
  • GC16M001427
  • GC16M001428
  • GC16M001432

Summaries for UNKL Gene

Entrez Gene Summary for UNKL Gene

  • This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for UNKL Gene

UNKL (Unkempt Family Zinc Finger-Like) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is UNK.

UniProtKB/Swiss-Prot for UNKL Gene

  • May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.

Gene Wiki entry for UNKL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNKL Gene

Genomics for UNKL Gene

Regulatory Elements for UNKL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UNKL Gene

Chromosome:
16
Start:
1,363,205 bp from pter
End:
1,414,751 bp from pter
Size:
51,547 bases
Orientation:
Minus strand

Genomic View for UNKL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNKL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNKL Gene

Proteins for UNKL Gene

  • Protein details for UNKL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9P5-UNKL_HUMAN
    Recommended name:
    Putative E3 ubiquitin-protein ligase UNKL
    Protein Accession:
    Q9H9P5
    Secondary Accessions:
    • B0QYN6
    • B1GXI8
    • Q96EV1
    • Q96RZ1
    • Q9BWL5
    • Q9H5K0
    • Q9UJJ8

    Protein attributes for UNKL Gene

    Size:
    680 amino acids
    Molecular mass:
    73828 Da
    Quaternary structure:
    • Isoform 4 (C-terminal) interacts with the GTP-bound form of RAC1. Isoform 4 (C-terminal) interacts with SMARCD2/BAF60b.

    Alternative splice isoforms for UNKL Gene

neXtProt entry for UNKL Gene

Proteomics data for UNKL Gene at MOPED

Post-translational modifications for UNKL Gene

  • Isoform 4 is ubiquitinated in the C-terminal. Ubiquitination is enhanced by activated RAC1. The presence of the RING finger domain is not essential for ubiquitination to occur
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for UNKL Gene

Domains & Families for UNKL Gene

Gene Families for UNKL Gene

Protein Domains for UNKL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UNKL Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9P5

UniProtKB/Swiss-Prot:

UNKL_HUMAN :
  • Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven.
  • Belongs to the unkempt family.
  • Contains 4 C3H1-type zinc fingers.
Domain:
  • Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven.
Family:
  • Belongs to the unkempt family.
Similarity:
  • Contains 4 C3H1-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with UNKL: view

Function for UNKL Gene

Molecular function for UNKL Gene

UniProtKB/Swiss-Prot Function:
May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.

Enzyme Numbers (IUBMB) for UNKL Gene

Gene Ontology (GO) - Molecular Function for UNKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20148946
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with UNKL: view
genes like me logo Genes that share phenotypes with UNKL: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNKL

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UNKL Gene

Localization for UNKL Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNKL Gene

Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNKL Gene COMPARTMENTS Subcellular localization image for UNKL gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for UNKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UNKL: view

Pathways & Interactions for UNKL Gene

SuperPathways for UNKL Gene

No Data Available

UniProtKB/Swiss-Prot Q9H9P5-UNKL_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for UNKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with UNKL: view

No data available for Pathways by source and SIGNOR curated interactions for UNKL Gene

Drugs & Compounds for UNKL Gene

No Compound Related Data Available

Transcripts for UNKL Gene

Unigene Clusters for UNKL Gene

Unkempt homolog (Drosophila)-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNKL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNKL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -
SP3: - -
SP4: -
SP5: - - -

Relevant External Links for UNKL Gene

GeneLoc Exon Structure for
UNKL
ECgene alternative splicing isoforms for
UNKL

Expression for UNKL Gene

mRNA expression in normal human tissues for UNKL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNKL Gene

This gene is overexpressed in Placenta (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UNKL Gene



SOURCE GeneReport for Unigene cluster for UNKL Gene Hs.643536

genes like me logo Genes that share expression patterns with UNKL: view

Protein tissue co-expression partners for UNKL Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UNKL Gene

Orthologs for UNKL Gene

This gene was present in the common ancestor of animals.

Orthologs for UNKL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UNKL 35
  • 82.84 (n)
  • 83.58 (a)
UNKL 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNKL 35
  • 82.02 (n)
  • 82.34 (a)
UNKL 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unkl 35
  • 82.84 (n)
  • 88.5 (a)
Unkl 16
Gm5819 36
  • 82 (a)
OneToMany
Unkl 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Unkl 35
  • 82.74 (n)
  • 89.09 (a)
oppossum
(Monodelphis domestica)
Mammalia UNKL 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNKL 36
  • 47 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UNKL 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNKL 35
  • 70.2 (n)
  • 83.33 (a)
UNKL 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unkl 35
  • 66.67 (n)
  • 72.27 (a)
zebrafish
(Danio rerio)
Actinopterygii unkl 35
  • 65.1 (n)
  • 66.76 (a)
UNKL 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10310 35
fruit fly
(Drosophila melanogaster)
Insecta unk 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C34D10.2 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for UNKL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNKL Gene

ENSEMBL:
Gene Tree for UNKL (if available)
TreeFam:
Gene Tree for UNKL (if available)

Paralogs for UNKL Gene

Paralogs for UNKL Gene

(1) SIMAP similar genes for UNKL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UNKL: view

Variants for UNKL Gene

Sequence variations from dbSNP and Humsavar for UNKL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs761066 -- 1,384,225(+) CACGG(C/T)GGGTG intron-variant
rs761068 -- 1,401,518(+) CTCGC(A/G)CTGTG intron-variant
rs909922 -- 1,404,081(+) CGCTC(C/T)GGCAT intron-variant
rs909923 -- 1,404,170(+) AGCCC(C/T)GGCTG intron-variant
rs1061497 -- 1,365,330(-) GATCC(A/G)ACGTC utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNKL Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv471066 CNV Loss 18288195
nsv428316 CNV Gain+Loss 18775914
dgv2505n71 CNV Loss 21882294
dgv2525n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
dgv2527n71 CNV Loss 21882294
dgv2528n71 CNV Loss 21882294
dgv2529n71 CNV Loss 21882294
nsv904978 CNV Loss 21882294
dgv2530n71 CNV Loss 21882294
dgv2531n71 CNV Loss 21882294
nsv827493 CNV Gain 20364138
nsv904990 CNV Loss 21882294
esv2606593 CNV Deletion 19546169
nsv512419 CNV Loss 21212237
esv2914 CNV Deletion 18987735
esv1002378 CNV Gain 20482838
esv24901 CNV Gain 19812545
esv8940 CNV Loss 19470904
esv2750334 CNV Deletion 23290073
nsv819318 CNV Loss 19587683
nsv904991 CNV Loss 21882294
dgv359e201 CNV Deletion 23290073
esv2750336 CNV Deletion 23290073
esv2750338 CNV Deletion 23290073
esv2750339 CNV Deletion 23290073
esv2750341 CNV Deletion 23290073
esv1007015 CNV Deletion 20482838
esv1006152 CNV Deletion 20482838
esv1590891 CNV Deletion 17803354
nsv457331 CNV Loss 19166990
nsv904993 CNV Gain 21882294
nsv819844 CNV Gain 19587683
nsv819259 CNV Gain 19587683
esv2750342 CNV Deletion 23290073
dgv2532n71 CNV Loss 21882294
dgv2533n71 CNV Loss 21882294

Variation tolerance for UNKL Gene

Gene Damage Index Score: 2.91; 48.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNKL Gene

HapMap Linkage Disequilibrium report
UNKL
Human Gene Mutation Database (HGMD)
UNKL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNKL Gene

Disorders for UNKL Gene

Relevant External Links for UNKL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNKL
genes like me logo Genes that share disorders with UNKL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNKL Gene

Publications for UNKL Gene

  1. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. (PMID: 20148946) Lores P. … Gacon G. (FEBS J. 2010) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 67
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67

Products for UNKL Gene

Sources for UNKL Gene

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