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UNKL Gene

protein-coding   GIFtS: 50
GCID: GC16M001432

Unkempt Family Zinc Finger-Like

(Previous names: chromosome 16 open reading frame 28, unkempt homolog (Drosophila)-like)
(Previous symbol: C16orf28)
  Search for UNKL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unkempt Family Zinc Finger-Like1 2     Chromosome 16 Open Reading Frame 281
C16orf281 2 3     Unkempt Homolog (Drosophila)-Like1
Zinc Finger CCCH Domain-Containing Protein 5-Like2 3     Putative E3 Ubiquitin-Protein Ligase UNKL2
ZC3H5L2 3     Unkempt Homolog-Like2
ZC3HDC5L2 3     EC 6.3.2.-3
RING Finger Protein Unkempt-Like2 3     

External Ids:    HGNC: 141841   Entrez Gene: 647182   Ensembl: ENSG000000591457   UniProtKB: Q9H9P53   

Export aliases for UNKL gene to outside databases

Previous GC identifers: GC16M001449 GC16M001373 GC16M001358 GC16M001414 GC16M001343 GC16M001418 GC16M001419 GC16M001420 GC16M001422 GC16M001427 GC16M001428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UNKL Gene:
This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated
factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript
variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for UNKL Gene:
UNKL (unkempt family zinc finger-like) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is UNK.

UniProtKB/Swiss-Prot: UNKL_HUMAN, Q9H9P5
Function: May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is
directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has
not been proven

Gene Wiki entry for UNKL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UNKL gene promoter:
         AML1a   Egr-1   FOXL1   Arnt   AREB6   PPAR-gamma1   PPAR-gamma2   ATF6   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UNKL promoter sequence
   Search Chromatin IP Primers for UNKL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNKL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

UNKL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNKL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001432:  view genomic region     (about GC identifiers)

Start:
1,413,206 bp from pter      End:
1,464,752 bp from pter
Size:
51,547 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UNKL_HUMAN, Q9H9P5 (See protein sequence)
Recommended Name: Putative E3 ubiquitin-protein ligase UNKL  
Size: 680 amino acids; 73828 Da
Subunit: Isoform 4 (C-terminal) interacts with the GTP-bound form of RAC1. Isoform 4 (C-terminal) interacts with
SMARCD2/BAF60b
Caution: Was termed (PubMed:20148946) Unkempt
Secondary accessions: B0QYN6 B1GXI8 Q96EV1 Q96RZ1 Q9BWL5 Q9H5K0 Q9UJJ8
Alternative splicing: 6 isoforms:  Q9H9P5-4   Q9H9P5-1   Q9H9P5-2   Q9H9P5-3   Q9H9P5-5   Q9H9P5-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNKL: NX_Q9H9P5

Explore proteomics data for UNKL at MOPED

Post-translational modifications: 

  • Isoform 4 is ubiquitinated in the C-terminal. Ubiquitination is enhanced by activated RAC1. The presence of the
    RING finger domain is not essential for ubiquitination to occur1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UNKL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001032202.1  NP_001180317.2  NP_001180318.1  NP_001263343.1  

    ENSEMBL proteins: 
     ENSP00000248104   ENSP00000380606   ENSP00000422852   ENSP00000384850   ENSP00000423107  
     ENSP00000372205   ENSP00000301712   ENSP00000373873   ENSP00000385895   ENSP00000375763  
     ENSP00000380604  

    UNKL Human Recombinant Protein Products:

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    Novus Biologicals UNKL Proteins
    Novus Biologicals UNKL Lysates
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    Cloud-Clone Corp. Proteins for UNKL

    UNKL Antibody Products:

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    Abcam antibodies for UNKL (Q96RZ1, Q9H9P5)
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    LSBio Antibodies in human, mouse, rat for UNKL

    UNKL Assay Products:

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    Cloud-Clone Corp. CLIAs for UNKL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing

    2 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q9H9P5

    ProtoNet protein and cluster: Q9H9P5

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: UNKL_HUMAN, Q9H9P5
    Domain: Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven
    (PubMed:20148946)
    Similarity: Belongs to the unkempt family
    Similarity: Contains 4 C3H1-type zinc fingers
    Similarity: Contains 1 RING-type zinc finger


    UNKL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNKL_HUMAN, Q9H9P5
    Function: May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is
    directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has
    not been proven

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    UNKL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UNKL:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UNKL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UNKL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UNKL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UNKL

    miRNA
    Products:
        
    miRTarBase miRNAs that target UNKL:
    hsa-mir-125b-5p (MIRT045960), hsa-mir-324-5p (MIRT043078), hsa-mir-615-3p (MIRT040051)

    Block miRNA regulation of human, mouse, rat UNKL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UNKL (see all 102):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): UNKL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UNKL
    Predesigned siRNA for gene silencing in human, mouse, rat UNKL

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for UNKL

    Clone
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    OriGene clones in human, mouse for UNKL (see all 21)
    OriGene ORF clones in mouse, rat for UNKL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): UNKL (NM_001037125)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNKL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNKL

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNKL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UNKL_HUMAN, Q9H9P5: Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but
    has the ability to shuttle between the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    UNKL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: UNKL_HUMAN, Q9H9P5
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNKL
    Interactions:

        Search GeneGlobe Interaction Network for UNKL

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for UNKL (Q9H9P51, 3 ENSP000003017124) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC1P630001, 3EBI-7797561,EBI-413628 I2D: score=2 
    SMARCD2Q929251, 3EBI-7797716,EBI-358441 I2D: score=2 
    HECAQ9UBI93I2D: score=5 
    SMAD1Q157973I2D: score=3 
    SMAD2Q157963I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    UNKL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNKL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UNKL gene (5 alternative transcripts): 
    NM_001037125.3  NM_001193388.3  NM_001193389.1  NM_001276414.1  NM_023076.4  

    Unigene Cluster for UNKL:

    Unkempt homolog (Drosophila)-like
    Hs.643536  [show with all ESTs]
    Unigene Representative Sequence: NM_001193388
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000248104(uc002clo.3) ENST00000562537 ENST00000397464 ENST00000508903
    ENST00000402641 ENST00000511095 ENST00000513783 ENST00000515195 ENST00000382757
    ENST00000509981 ENST00000301712(uc002clq.3) ENST00000502438 ENST00000503648
    ENST00000566707 ENST00000561783 ENST00000389221(uc010brn.2) ENST00000403703(uc002cln.3 uc002clp.3)
    ENST00000391893
    miRNA
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    Block miRNA regulation of human, mouse, rat UNKL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UNKL (see all 102):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): UNKL 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UNKL
    Predesigned siRNA for gene silencing in human, mouse, rat UNKL
    Clone
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    OriGene clones in human, mouse for UNKL (see all 21)
    OriGene ORF clones in mouse, rat for UNKL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): UNKL (NM_001037125)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNKL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNKL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UNKL
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UNKL
      QuantiTect SYBR Green Assays in human, mouse, rat UNKL
      QuantiFast Probe-based Assays in human, mouse, rat UNKL

    Additional mRNA sequence: 

    AK022685.1 AK024842.1 AK027013.1 AK124977.1 AM944365.1 BC000150.1 BC011924.2 

    14 DOTS entries:

    DT.97836038  DT.101979057  DT.75101053  DT.209076  DT.100748271  DT.120662060  DT.92416459  DT.100681107 
    DT.316570  DT.91936791  DT.120662126  DT.120662105  DT.75171129  DT.97778974 

    20 AceView cDNA sequences:

    AK124977 CD675420 NM_023076 BC000150 NM_024023 AI400804 AK022685 BC011924 
    BF513084 AK027013 BF115402 AW592111 AK024842 AA760804 CF136587 BG059385 
    AW971542 H92871 CD631744 BF943831 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UNKL    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                                        
    SP2:                                                  -                     
    SP3:                                                  -     -               
    SP4:                    -                                                   
    SP5:                                                  -     -     -         


    ECgene alternative splicing isoforms for UNKL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UNKL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTATTTT
    UNKL Expression
    About this image


    UNKL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    UNKL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNKL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643536
        Custom PCR Arrays for UNKL
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNKL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UNKL gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unkl1 , 5 unkempt-like (Drosophila)1, 5 82.84(n)1
    88.5(a)1
      17 (12.53 cM)5
    741541  NM_001197024.11  NP_001183953.11 
     251883975 
    chicken
    (Gallus gallus)
    Aves UNKL1 unkempt homolog (Drosophila)-like 70.2(n)
    83.33(a)
      416593  XM_004945284.1  XP_004945341.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia unkl1 unkempt family zinc finger-like 66.67(n)
    72.27(a)
      100144682  NM_001123443.1  NP_001116915.1 
    zebrafish
    (Danio rerio)
    Actinopterygii unkl1 unkempt homolog (Drosophila)-like 65.1(n)
    66.76(a)
      565405  XM_005164231.1  XP_005164288.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta unk6
    unkempt
    37(a)
    1 → many
    3R(18975963-18983592)
    worm
    (Caenorhabditis elegans)
    Secernentea C34D10.26
    Protein C34D10.2, isoform b (C34D10.2) mRNA, compl...
    32(a)
    1 → many
    X(8015044-8026799) WBGene00016407


    ENSEMBL Gene Tree for UNKL (if available)
    TreeFam Gene Tree for UNKL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UNKL gene
    UNK2  
    1 SIMAP similar gene for UNKL using alignment to 4 protein entries:     UNKL_HUMAN (see all proteins):
    UNK

    UNKL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UNKL (see all 1501)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454756681,2
    --1393145(+) AGAAAC/GAGGTT 2 -- int10--------
    rs1890263301,2
    --1393187(+) GGAGCA/CTGTGA 2 -- int10--------
    rs1402261971,2
    C--1393351(+) AAAGGA/GAACTG 2 -- int10--------
    rs1440540941,2
    --1393359(+) CTGATG/TTAAGA 2 -- int10--------
    rs575573111,2
    C,F--1413921(+) GCCCTG/CGAGAC 4 -- ut312Minor allele frequency- C:0.06WA 120
    rs1435106481,2
    C--1413938(+) AGGGGC/TGGGCG 4 -- ut310--------
    rs758896831,2
    F--1414018(+) CGGGAG/AATGTC 4 -- ut311Minor allele frequency- A:0.01WA 118
    rs1462673921,2
    C--1414074(+) GGAACC/GAAGTG 4 -- ut310--------
    rs1856466631,2
    --1414093(+) CAAATA/GAAAAC 4 -- ut310--------
    rs1150220611,2
    C,F--1414154(+) ACTGAG/ACTAAT 4 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for UNKL (1413206 - 1464752 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UNKL (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750336CNV Deletion23290073
    esv2750338CNV Deletion23290073
    esv1006152CNV Deletion20482838
    esv2750342CNV Deletion23290073
    esv2750339CNV Deletion23290073
    esv2750341CNV Deletion23290073
    esv2606593CNV Deletion19546169
    esv2750334CNV Deletion23290073
    esv1590891CNV Deletion17803354
    dgv359e201CNV Deletion23290073

    Human Gene Mutation Database (HGMD): UNKL
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    UNKL for disorders           About GeneDecksing


    Export disorders for UNKL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UNKL gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with UNKL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. (PubMed id 20148946)1, 2, 3 Lores P.... Gacon G. (FEBS J. 2010)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
    10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64718 HGNC: 14184 AceView: UNKLandC16orf28 Ensembl:ENSG00000059145 euGenes: HUgn64718
    ECgene: UNKL H-InvDB: UNKL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UNKL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UNKL gene:
    Search GeneIP for patents involving UNKL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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