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Aliases for UNK Gene

Aliases for UNK Gene

  • Unkempt Family Zinc Finger 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 5 3 4
  • Zinc Finger CCCH-Type Domain Containing 5 2 3
  • Zinc Finger CCCH-Type Containing 5 2 3
  • ZC3HDC5 3 4
  • ZC3H5 3 4
  • Zinc Finger CCCH Type Domain Containing 5 3
  • Unkempt Homolog (Drosophila) 2
  • Unkempt Homolog 3
  • KIAA1753 4
  • UNKEMPT 3

External Ids for UNK Gene

Previous HGNC Symbols for UNK Gene

  • ZC3HDC5
  • ZC3H5

Previous GeneCards Identifiers for UNK Gene

  • GC17P071293
  • GC17P073780
  • GC17P069206

Summaries for UNK Gene

GeneCards Summary for UNK Gene

UNK (Unkempt Family Zinc Finger) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is UNKL.

UniProtKB/Swiss-Prot for UNK Gene

  • Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNK Gene

Genomics for UNK Gene

Regulatory Elements for UNK Gene

Promoters for UNK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UNK on UCSC Golden Path with GeneCards custom track

Genomic Location for UNK Gene

Chromosome:
17
Start:
75,784,771 bp from pter
End:
75,825,805 bp from pter
Size:
41,035 bases
Orientation:
Plus strand

Genomic View for UNK Gene

Genes around UNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNK Gene

Proteins for UNK Gene

  • Protein details for UNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B0-UNK_HUMAN
    Recommended name:
    RING finger protein unkempt homolog
    Protein Accession:
    Q9C0B0

    Protein attributes for UNK Gene

    Size:
    810 amino acids
    Molecular mass:
    88084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH53362.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for UNK Gene

Proteomics data for UNK Gene at MOPED

Post-translational modifications for UNK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNK Gene

No data available for DME Specific Peptides for UNK Gene

Domains & Families for UNK Gene

Gene Families for UNK Gene

Protein Domains for UNK Gene

Suggested Antigen Peptide Sequences for UNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0B0

UniProtKB/Swiss-Prot:

UNK_HUMAN :
  • Belongs to the unkempt family.
  • Contains 5 C3H1-type zinc fingers.
Family:
  • Belongs to the unkempt family.
Similarity:
  • Contains 5 C3H1-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with UNK: view

Function for UNK Gene

Molecular function for UNK Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).

Gene Ontology (GO) - Molecular Function for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:1990715 mRNA CDS binding IEA,IDA 25737280
genes like me logo Genes that share ontologies with UNK: view
genes like me logo Genes that share phenotypes with UNK: view

Animal Model Products

miRNA for UNK Gene

miRTarBase miRNAs that target UNK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNK Gene

Localization for UNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNK Gene COMPARTMENTS Subcellular localization image for UNK gene
Compartment Confidence
cytosol 4
nucleus 4
chloroplast 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UNK: view

Pathways & Interactions for UNK Gene

SuperPathways for UNK Gene

No Data Available

Interacting Proteins for UNK Gene

Selected Interacting proteins: Q9C0B0-UNK_HUMAN for UNK Gene via I2D MINT

Gene Ontology (GO) - Biological Process for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048667 cell morphogenesis involved in neuron differentiation IEA,IMP 25737280
GO:2000766 negative regulation of cytoplasmic translation IMP 25737280
genes like me logo Genes that share ontologies with UNK: view

No data available for Pathways by source and SIGNOR curated interactions for UNK Gene

Drugs & Compounds for UNK Gene

No Compound Related Data Available

Transcripts for UNK Gene

Unigene Clusters for UNK Gene

Unkempt homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - -
SP2: - - - - - - - - - -
SP3:
SP4: - -
SP5: - - - - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10: -

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for UNK Gene

GeneLoc Exon Structure for
UNK
ECgene alternative splicing isoforms for
UNK

Expression for UNK Gene

mRNA expression in normal human tissues for UNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNK Gene

This gene is overexpressed in CD4 Tcells (13.4), Placenta (7.9), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for UNK Gene



SOURCE GeneReport for Unigene cluster for UNK Gene Hs.584768

genes like me logo Genes that share expression patterns with UNK: view

Protein tissue co-expression partners for UNK Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UNK Gene

Orthologs for UNK Gene

This gene was present in the common ancestor of animals.

Orthologs for UNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNK 35
  • 99.44 (n)
  • 99.74 (a)
UNK 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNK 36
  • 98 (a)
OneToOne
UNK 35
  • 91.91 (n)
  • 97.47 (a)
dog
(Canis familiaris)
Mammalia UNK 35
  • 92.71 (n)
  • 97.85 (a)
UNK 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unk 16
Unk 36
  • 95 (a)
OneToOne
Unk 35
  • 91.32 (n)
  • 95.32 (a)
oppossum
(Monodelphis domestica)
Mammalia UNK 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Unk 35
  • 90.52 (n)
  • 94.82 (a)
chicken
(Gallus gallus)
Aves UNK 36
  • 85 (a)
OneToOne
UNK 35
  • 79.21 (n)
  • 88.99 (a)
lizard
(Anolis carolinensis)
Reptilia UNK 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398497 35
tropical clawed frog
(Silurana tropicalis)
Amphibia unk 35
  • 73.59 (n)
  • 82.38 (a)
zebrafish
(Danio rerio)
Actinopterygii unk 36
  • 59 (a)
OneToOne
unk 35
  • 66.5 (n)
  • 70 (a)
zgc55407 35
fruit fly
(Drosophila melanogaster)
Insecta unk 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C34D10.2 36
  • 31 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1907 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for UNK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNK Gene

ENSEMBL:
Gene Tree for UNK (if available)
TreeFam:
Gene Tree for UNK (if available)

Paralogs for UNK Gene

Paralogs for UNK Gene

(1) SIMAP similar genes for UNK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UNK: view

Variants for UNK Gene

Sequence variations from dbSNP and Humsavar for UNK Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1965261 -- 75,790,897(+) ATCAC(A/G)CTACT intron-variant
rs3803733 -- 75,813,361(+) GGCAT(A/G)GTGAG intron-variant, upstream-variant-2KB
rs3214865 -- 75,825,535(+) TTAGC(-/TT)CCATT utr-variant-3-prime
rs4788910 -- 75,798,132(+) ATGGC(A/G)CGATT intron-variant
rs4789228 -- 75,799,198(+) tccca(A/G)ctact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNK Gene

Variant ID Type Subtype PubMed ID
dgv3264n71 CNV Loss 21882294
nsv908804 CNV Loss 21882294
dgv3267n71 CNV Loss 21882294
dgv3268n71 CNV Loss 21882294
nsv833545 CNV Gain 17160897
nsv470606 CNV Loss 18288195
nsv908820 CNV Loss 21882294
nsv510728 CNV Loss 20534489
esv2716246 CNV Deletion 23290073
esv2716247 CNV Deletion 23290073
esv2716248 CNV Deletion 23290073
esv2743244 CNV Deletion 23290073
esv2716249 CNV Deletion 23290073

Variation tolerance for UNK Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNK Gene

HapMap Linkage Disequilibrium report
UNK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNK Gene

Disorders for UNK Gene

Relevant External Links for UNK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNK

No disorders were found for UNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNK Gene

Publications for UNK Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  3. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3

Products for UNK Gene

Sources for UNK Gene

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