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Aliases for UNK Gene

Aliases for UNK Gene

  • Unkempt Family Zinc Finger 2 3
  • Zinc Finger CCCH Domain-Containing Protein 5 3 4
  • Zinc Finger CCCH-Type Domain Containing 5 2 3
  • Zinc Finger CCCH-Type Containing 5 2 3
  • ZC3HDC5 3 4
  • ZC3H5 3 4
  • Zinc Finger CCCH Type Domain Containing 5 3
  • RING Finger Protein Unkempt Homolog 3
  • Unkempt Homolog (Drosophila) 2
  • Unkempt Homolog 3
  • KIAA1753 4
  • H 6

External Ids for UNK Gene

Previous HGNC Symbols for UNK Gene

  • ZC3HDC5
  • ZC3H5

Previous GeneCards Identifiers for UNK Gene

  • GC17P071293
  • GC17P073780
  • GC17P069206

Summaries for UNK Gene

GeneCards Summary for UNK Gene

UNK (Unkempt Family Zinc Finger) is a Protein Coding gene. An important paralog of this gene is UNKL.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNK Gene

Genomics for UNK Gene

Regulatory Elements for UNK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UNK Gene

75,784,771 bp from pter
75,825,805 bp from pter
41,035 bases
Plus strand

Genomic View for UNK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNK Gene

Proteins for UNK Gene

  • Protein details for UNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein unkempt homolog
    Protein Accession:
    Secondary Accessions:

    Protein attributes for UNK Gene

    810 amino acids
    Molecular mass:
    88084 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH53362.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21844.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UNK Gene

Proteomics data for UNK Gene at MOPED

Post-translational modifications for UNK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNK Gene

No data available for DME Specific Peptides for UNK Gene

Domains for UNK Gene

Gene Families for UNK Gene

Protein Domains for UNK Gene

Suggested Antigen Peptide Sequences for UNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the unkempt family.
  • Contains 5 C3H1-type zinc fingers.
  • Belongs to the unkempt family.
  • Contains 5 C3H1-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with UNK: view

Function for UNK Gene

Gene Ontology (GO) - Molecular Function for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with UNK: view

Animal Model Products

miRNA for UNK Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNK

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for UNK Gene

Localization for UNK Gene

Subcellular locations from

Jensen Localization Image for UNK Gene COMPARTMENTS Subcellular localization image for UNK gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UNK Gene

Pathways for UNK Gene

SuperPathways for UNK Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for UNK Gene

Selected Interacting proteins: Q9C0B0-UNK_HUMAN for UNK Gene via MINT I2D

Gene Ontology (GO) - Biological Process for UNK Gene


No data available for Pathways by source for UNK Gene

Transcripts for UNK Gene

Unigene Clusters for UNK Gene

Unkempt homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - -
SP2: - - - - - - - - - -
SP4: - -
SP5: - - - - - - -
SP7: - - - -
SP10: -

ExUns: 16 ^ 17

Relevant External Links for UNK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNK Gene

mRNA expression in normal human tissues for UNK Gene

Protein differential expression in normal tissues for UNK Gene

This gene is overexpressed in CD4 Tcells (13.4), Placenta (7.9), and Fetal Brain (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for UNK Gene

SOURCE GeneReport for Unigene cluster for UNK Gene Hs.584768

genes like me logo Genes that share expressions with UNK: view

Expression partners for UNK Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UNK Gene

Orthologs for UNK Gene

This gene was present in the common ancestor of animals.

Orthologs for UNK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UNK 35
  • 91.91 (n)
  • 97.47 (a)
UNK 36
  • 98 (a)
(Canis familiaris)
Mammalia UNK 35
  • 92.71 (n)
  • 97.85 (a)
UNK 36
  • 90 (a)
(Mus musculus)
Mammalia Unk 35
  • 91.32 (n)
  • 95.32 (a)
Unk 16
Unk 36
  • 95 (a)
(Pan troglodytes)
Mammalia UNK 35
  • 99.44 (n)
  • 99.74 (a)
UNK 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Unk 35
  • 90.52 (n)
  • 94.82 (a)
(Monodelphis domestica)
Mammalia UNK 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 54 (a)
(Gallus gallus)
Aves UNK 35
  • 79.21 (n)
  • 88.99 (a)
UNK 36
  • 85 (a)
(Anolis carolinensis)
Reptilia UNK 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia unk 35
  • 73.59 (n)
  • 82.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398497 35
(Danio rerio)
Actinopterygii unk 35
  • 66.5 (n)
  • 70 (a)
zgc55407 35
unk 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta unk 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea C34D10.2 36
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1907 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for UNK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNK Gene

Gene Tree for UNK (if available)
Gene Tree for UNK (if available)

Paralogs for UNK Gene

Paralogs for UNK Gene

(1) SIMAP similar genes for UNK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UNK: view

Variants for UNK Gene

Sequence variations from dbSNP and Humsavar for UNK Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1047743 -- 75,794,012(+) CCAGG(C/G)ATCTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1113758 -- 75,804,527(-) tctct(C/T)ttaat intron-variant
rs4318268 -- 75,809,231(+) GTCCC(G/T)AGGGA intron-variant
rs4427862 -- 75,787,324(+) ctccc(A/C)cctca intron-variant
rs4496219 -- 75,787,366(+) CTGGA(A/T)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNK Gene

Variant ID Type Subtype PubMed ID
dgv3264n71 CNV Loss 21882294
nsv908804 CNV Loss 21882294
dgv3267n71 CNV Loss 21882294
dgv3268n71 CNV Loss 21882294
nsv833545 CNV Gain 17160897
nsv470606 CNV Loss 18288195
nsv908820 CNV Loss 21882294
nsv510728 CNV Loss 20534489
esv2716246 CNV Deletion 23290073
esv2716247 CNV Deletion 23290073
esv2716248 CNV Deletion 23290073
esv2743244 CNV Deletion 23290073
esv2716249 CNV Deletion 23290073

Relevant External Links for UNK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNK Gene

Disorders for UNK Gene

No disorders were found for UNK Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for UNK Gene

Publications for UNK Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao W.A. … Aebersold R. (Nat. Methods 2005) 3
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for UNK Gene

Sources for UNK Gene

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