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Aliases for UNK Gene

Aliases for UNK Gene

  • Unkempt Family Zinc Finger 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 5 3 4
  • Zinc Finger CCCH-Type Domain Containing 5 2 3
  • Zinc Finger CCCH-Type Containing 5 2 3
  • ZC3HDC5 3 4
  • ZC3H5 3 4
  • RING Finger Protein Unkempt Homolog 3
  • Unkempt Homolog (Drosophila) 2
  • Unkempt Homolog 3
  • KIAA1753 4
  • UNKEMPT 3

External Ids for UNK Gene

Previous HGNC Symbols for UNK Gene

  • ZC3HDC5
  • ZC3H5

Previous GeneCards Identifiers for UNK Gene

  • GC17P071293
  • GC17P073780
  • GC17P069206

Summaries for UNK Gene

GeneCards Summary for UNK Gene

UNK (Unkempt Family Zinc Finger) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is UNKL.

UniProtKB/Swiss-Prot for UNK Gene

  • Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).

Additional gene information for UNK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNK Gene

Genomics for UNK Gene

Regulatory Elements for UNK Gene

Enhancers for UNK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H076734 2.7 Ensembl ENCODE dbSUPER 197.6 +952.5 952488 7.8 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A UNK SRSF2 ENSG00000267342 TRIM65 ENSG00000266980 ENSG00000267546 SEPT9 CDK3 METTL23 MFSD11
GH17H076258 2 FANTOM5 Ensembl ENCODE dbSUPER 95.8 +483.2 483205 19.6 DMAP1 YY1 ZNF143 SP3 ZC3H11A NFYC MEF2D ZNF610 ZNF585B GLIS1 UNK ENSG00000267342 SRSF2 TRIM65 ENSG00000266980 ENSG00000267546 EXOC7 RNF157 MFSD11 PRPSAP1
GH17H075085 2 FANTOM5 Ensembl ENCODE dbSUPER 85.3 -693.3 -693276 11.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 NUP85 UNK NT5C ENSG00000266980 ENSG00000267342 NAT9 GGA3 TRIM65 RN7SL573P SAP30BP
GH17H075776 2.4 ENCODE dbSUPER 63.8 -6.2 -6245 4.9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 UNK NUP85 SRSF2 ENSG00000267342 NT5C ENSG00000266980 MFSD11 METTL23 TRIM65 GGA3
GH17H076542 1.6 Ensembl ENCODE dbSUPER 80.8 +760.3 760295 5.9 HDGF PKNOX1 FOXA2 ARNT ARID4B YBX1 ZNF2 ZNF207 ZNF143 FOS UNK SRSF2 ENSG00000267342 ENSG00000267543 ENSG00000266980 METTL23 SEPT9 TRIM65 SNHG16 PRPSAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UNK on UCSC Golden Path with GeneCards custom track

Promoters for UNK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098450 329 1401 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 MEF2D ZNF610

Genomic Locations for UNK Gene

Genomic Locations for UNK Gene
chr17:75,784,771-75,825,805
(GRCh38/hg38)
Size:
41,035 bases
Orientation:
Plus strand
chr17:73,780,681-73,821,886
(GRCh37/hg19)

Genomic View for UNK Gene

Genes around UNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNK Gene

Proteins for UNK Gene

  • Protein details for UNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B0-UNK_HUMAN
    Recommended name:
    RING finger protein unkempt homolog
    Protein Accession:
    Q9C0B0

    Protein attributes for UNK Gene

    Size:
    810 amino acids
    Molecular mass:
    88084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH53362.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for UNK Gene

Post-translational modifications for UNK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UNK Gene

Domains & Families for UNK Gene

Gene Families for UNK Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UNK Gene

Suggested Antigen Peptide Sequences for UNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0B0

UniProtKB/Swiss-Prot:

UNK_HUMAN :
  • Belongs to the unkempt family.
Family:
  • Belongs to the unkempt family.
genes like me logo Genes that share domains with UNK: view

Function for UNK Gene

Molecular function for UNK Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).

Phenotypes From GWAS Catalog for UNK Gene

Gene Ontology (GO) - Molecular Function for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22658674
GO:0046872 metal ion binding IEA --
GO:1990715 mRNA CDS binding IDA 25737280
genes like me logo Genes that share ontologies with UNK: view
genes like me logo Genes that share phenotypes with UNK: view

Animal Models for UNK Gene

MGI Knock Outs for UNK:
  • Unk tm1a(KOMP)Wtsi

miRNA for UNK Gene

miRTarBase miRNAs that target UNK

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNK Gene

Localization for UNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNK gene
Compartment Confidence
nucleus 4
cytosol 4
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005844 colocalizes_with polysome IDA 25737280
genes like me logo Genes that share ontologies with UNK: view

Pathways & Interactions for UNK Gene

No Data Available

Interacting Proteins for UNK Gene

Gene Ontology (GO) - Biological Process for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006417 regulation of translation IEA --
GO:0048667 cell morphogenesis involved in neuron differentiation IMP 25737280
GO:2000766 negative regulation of cytoplasmic translation IMP 25737280
genes like me logo Genes that share ontologies with UNK: view

No data available for Pathways by source and SIGNOR curated interactions for UNK Gene

Drugs & Compounds for UNK Gene

No Compound Related Data Available

Transcripts for UNK Gene

Unigene Clusters for UNK Gene

Unkempt homolog (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - -
SP2: - - - - - - - - - -
SP3:
SP4: - -
SP5: - - - - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10: -

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for UNK Gene

GeneLoc Exon Structure for
UNK
ECgene alternative splicing isoforms for
UNK

Expression for UNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNK Gene

This gene is overexpressed in CD4 Tcells (13.4), Placenta (7.9), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UNK Gene



Protein tissue co-expression partners for UNK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNK Gene:

UNK

SOURCE GeneReport for Unigene cluster for UNK Gene:

Hs.584768

Evidence on tissue expression from TISSUES for UNK Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with UNK: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNK Gene

Orthologs for UNK Gene

This gene was present in the common ancestor of animals.

Orthologs for UNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNK 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia UNK 33 34
  • 92.71 (n)
cow
(Bos Taurus)
Mammalia UNK 33 34
  • 91.91 (n)
mouse
(Mus musculus)
Mammalia Unk 33 16 34
  • 91.32 (n)
rat
(Rattus norvegicus)
Mammalia Unk 33
  • 90.52 (n)
oppossum
(Monodelphis domestica)
Mammalia UNK 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves UNK 33 34
  • 79.21 (n)
lizard
(Anolis carolinensis)
Reptilia UNK 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unk 33
  • 73.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398497 33
zebrafish
(Danio rerio)
Actinopterygii unk 34 33
  • 66.5 (n)
OneToOne
zgc55407 33
fruit fly
(Drosophila melanogaster)
Insecta unk 34
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C34D10.2 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1907 33
Species where no ortholog for UNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNK Gene

ENSEMBL:
Gene Tree for UNK (if available)
TreeFam:
Gene Tree for UNK (if available)

Paralogs for UNK Gene

Paralogs for UNK Gene

(1) SIMAP similar genes for UNK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UNK: view

Variants for UNK Gene

Sequence variations from dbSNP and Humsavar for UNK Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000085815 -- 75,788,397(+) CTGAT(A/C)TCGAA intron-variant
rs1000110712 -- 75,794,586(+) TGAGC(C/T)GAGAT intron-variant, utr-variant-5-prime
rs1000114933 -- 75,788,668(+) TATTT(C/T)TAATT intron-variant
rs1000168647 -- 75,787,942(+) ACCAC(C/T)ATACC intron-variant
rs1000171098 -- 75,818,528(+) GCACC(C/T)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNK Gene

Variant ID Type Subtype PubMed ID
nsv833545 CNV gain 17160897
nsv510728 CNV deletion 20534489
nsv470606 CNV loss 18288195
esv2743244 CNV deletion 23290073
esv2716249 CNV deletion 23290073
esv2716248 CNV deletion 23290073
esv2716247 CNV deletion 23290073
esv2716246 CNV deletion 23290073

Variation tolerance for UNK Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNK Gene

Disorders for UNK Gene

Relevant External Links for UNK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNK

No disorders were found for UNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNK Gene

Publications for UNK Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens AL … Gingras AC (Science signaling 2013) 3 60

Products for UNK Gene

Sources for UNK Gene

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