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Aliases for UNG Gene

Aliases for UNG Gene

  • Uracil-DNA Glycosylase 2 3
  • DGU 3 4 6
  • HIGM5 3 6
  • UNG15 3 4
  • UNG1 3 4
  • UDG 3 4
  • Uracil-DNA Glycosylase 1, Uracil-DNA Glycosylase 2 3
  • Uracil-DNA Glycosylase 1 2
  • Uracil-DNA Glycosylase 2 2
  • EC 4
  • EC 3.2.2 63
  • HIGM4 3
  • UNG2 3

External Ids for UNG Gene

Previous HGNC Symbols for UNG Gene

  • DGU

Previous GeneCards Identifiers for UNG Gene

  • GC12P108593
  • GC12P109374
  • GC12P107998
  • GC12P109535
  • GC12P106553

Summaries for UNG Gene

Entrez Gene Summary for UNG Gene

  • This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

GeneCards Summary for UNG Gene

UNG (Uracil-DNA Glycosylase) is a Protein Coding gene. Diseases associated with UNG include immunodeficiency with hyper igm, type 5 and congenital rubella. Among its related pathways are Chks in Checkpoint Regulation and Primary immunodeficiency. GO annotations related to this gene include uracil DNA N-glycosylase activity.

UniProtKB/Swiss-Prot for UNG Gene

  • Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

Gene Wiki entry for UNG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNG Gene

Genomics for UNG Gene

Regulatory Elements for UNG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UNG Gene

109,097,574 bp from pter
109,110,993 bp from pter
13,420 bases
Plus strand

Genomic View for UNG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNG Gene

Proteins for UNG Gene

  • Protein details for UNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uracil-DNA glycosylase
    Protein Accession:
    Secondary Accessions:
    • A8K5M6
    • B2R8Y1
    • O00637
    • O00719
    • Q93028

    Protein attributes for UNG Gene

    313 amino acids
    Molecular mass:
    34645 Da
    Quaternary structure:
    • Monomer. Interacts with FAM72A. Interacts with HIV-1 Vpr.

    Three dimensional structures from OCA and Proteopedia for UNG Gene

    Alternative splice isoforms for UNG Gene


neXtProt entry for UNG Gene

Proteomics data for UNG Gene at MOPED

Selected DME Specific Peptides for UNG Gene

Post-translational modifications for UNG Gene

Other Protein References for UNG Gene

Antibody Products

Domains for UNG Gene

Gene Families for UNG Gene

Suggested Antigen Peptide Sequences for UNG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the uracil-DNA glycosylase family.
  • Belongs to the uracil-DNA glycosylase family.
genes like me logo Genes that share domains with UNG: view

Function for UNG Gene

Molecular function for UNG Gene

GENATLAS Biochemistry:
DNA glycosylase,uracil,nuclear form (UNG2),and mitochondrial form (UNG1),base excision repair
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
UniProtKB/Swiss-Prot Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

Enzyme Numbers (IUBMB) for UNG Gene

Gene Ontology (GO) - Molecular Function for UNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004844 uracil DNA N-glycosylase activity NAS 9016624
GO:0005515 protein binding IPI 10982866
genes like me logo Genes that share ontologies with UNG: view
genes like me logo Genes that share phenotypes with UNG: view

Animal Models for UNG Gene

MGI Knock Outs for UNG:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for UNG Gene

Localization for UNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNG Gene

Isoform 1: Mitochondrion.
Isoform 2: Nucleus.

Subcellular locations from

Jensen Localization Image for UNG Gene COMPARTMENTS Subcellular localization image for UNG gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for UNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9016624
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with UNG: view

Pathways for UNG Gene

genes like me logo Genes that share pathways with UNG: view

Pathways by source for UNG Gene

1 Qiagen pathway for UNG Gene
2 KEGG pathways for UNG Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for UNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006285 base-excision repair, AP site formation TAS --
GO:0016032 viral process IEA --
GO:0016446 somatic hypermutation of immunoglobulin genes IEA --
genes like me logo Genes that share ontologies with UNG: view

Drugs for UNG Gene

(4) Drugbank Compounds for UNG Gene

(52) Novoseek inferred chemical compound relationships for UNG Gene

Compound -log(P) Hits PubMed IDs
cytosine 85 25
deoxyuridine 80 11
5-formyluracil 79.6 3
cytidine 78.3 10
5-hydroxymethyluracil 77.9 3
genes like me logo Genes that share compounds with UNG: view

Transcripts for UNG Gene

Unigene Clusters for UNG Gene

Uracil-DNA glycosylase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNG Gene

No ASD Table

Relevant External Links for UNG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNG Gene

mRNA expression in normal human tissues for UNG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UNG Gene

This gene is overexpressed in Heart (40.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UNG Gene

SOURCE GeneReport for Unigene cluster for UNG Gene Hs.191334

mRNA Expression by UniProt/SwissProt for UNG Gene

Tissue specificity: Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells
genes like me logo Genes that share expressions with UNG: view

Expression partners for UNG Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UNG Gene

Orthologs for UNG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UNG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UNG 35
  • 86.86 (n)
  • 94.05 (a)
UNG 36
  • 84 (a)
(Canis familiaris)
Mammalia UNG 35
  • 88.72 (n)
  • 94.42 (a)
UNG 36
  • 86 (a)
(Mus musculus)
Mammalia Ung 35
  • 83.66 (n)
  • 86.93 (a)
Ung 16
Ung 36
  • 86 (a)
(Pan troglodytes)
Mammalia UNG 35
  • 99.57 (n)
  • 100 (a)
UNG 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ung 35
  • 85.07 (n)
  • 91.89 (a)
(Monodelphis domestica)
Mammalia UNG 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia UNG 36
  • 89 (a)
(Gallus gallus)
Aves UNG 35
  • 73.58 (n)
  • 75.59 (a)
-- 36
  • 46 (a)
UNG 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7397 35
ung 35
  • 68.88 (n)
  • 73.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6649 35
(Danio rerio)
Actinopterygii unga 35
  • 69.07 (n)
  • 71.82 (a)
zgc56102 35
unga 36
  • 70 (a)
(Caenorhabditis elegans)
Secernentea Y56A3A.29a 37
  • 54 (a)
ung-1 35
  • 54.59 (n)
  • 55.5 (a)
ung-1 36
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER327C 35
  • 53.55 (n)
  • 54.98 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01265g 35
  • 55.82 (n)
  • 56.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UNG1 35
  • 52.56 (n)
  • 55.35 (a)
UNG1 36
  • 36 (a)
UNG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UNG 35
  • 55.35 (n)
  • 55.81 (a)
(Oryza sativa)
Liliopsida Os04g0673400 35
  • 57.22 (n)
  • 56.7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1651 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07482 35
  • 52.4 (n)
  • 49.3 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ung1 35
  • 53.12 (n)
  • 51.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
CSA.8269 36
  • 47 (a)
Species with no ortholog for UNG:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNG Gene

Gene Tree for UNG (if available)
Gene Tree for UNG (if available)

Paralogs for UNG Gene

(1) SIMAP similar genes for UNG Gene using alignment to 3 proteins: Pseudogenes for UNG Gene

genes like me logo Genes that share paralogs with UNG: view

No data available for Paralogs for UNG Gene

Variants for UNG Gene

Sequence variations from dbSNP and Humsavar for UNG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs39655 -- 109,111,108(+) GGAGG(G/T)GCCGC downstream-variant-500B
rs246078 -- 109,105,909(+) GGTAG(A/G)GGGGT intron-variant
rs246079 -- 109,109,255(+) CTGGC(A/G)GTATG intron-variant
rs246080 -- 109,109,483(+) TTGGG(A/G)AAAAA intron-variant
rs1018782 -- 109,098,004(+) ATGGG(A/G)ACGCG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNG Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV Duplication 17116639
nsv526106 CNV Loss 19592680
esv1652073 CNV Insertion 17803354

Relevant External Links for UNG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNG Gene

Disorders for UNG Gene

(1) OMIM Diseases for UNG Gene (191525)


  • Immunodeficiency with hyper-IgM 5 (HIGM5) [MIM:608106]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. {ECO:0000269 PubMed:12958596}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(17) Novoseek inferred disease relationships for UNG Gene

Disease -log(P) Hits PubMed IDs
hyper-igm syndrome 75.4 4
bloom syndrome 53.6 2
immunodeficiency 33.4 6
herpes simplex 29 12
colon adenocarcinoma 6.14 1

Relevant External Links for UNG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UNG: view

No data available for University of Copenhagen DISEASES and Genatlas for UNG Gene

Publications for UNG Gene

  1. A nucleotide-flipping mechanism from the structure of human uracil- DNA glycosylase bound to DNA. (PMID: 8900285) Slupphaug G. … Tainer J.A. (Nature 1996) 3 4 23
  2. Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. (PMID: 19403629) Chanson A. … Mason J.B. (Am. J. Clin. Nutr. 2009) 3 23 48
  3. Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. (PMID: 17101234) Akbari M. … Krokan H.E. (Neuroscience 2007) 2 3 23
  4. B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. (PMID: 15967827) Kavli B. … Slupphaug G. (J. Exp. Med. 2005) 3 4 23
  5. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. (PMID: 12958596) Imai K. … Durandy A. (Nat. Immunol. 2003) 3 4 23

Products for UNG Gene

  • Addgene plasmids for UNG

Sources for UNG Gene

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