Aliases for UNG Gene
External Ids for UNG Gene
Previous HGNC Symbols for UNG Gene
Previous GeneCards Identifiers for UNG Gene
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
GeneCards Summary for UNG Gene
UNG (Uracil DNA Glycosylase) is a Protein Coding gene. Diseases associated with UNG include Immunodeficiency With Hyper Igm, Type 5 and Ciliary Dyskinesia, Primary, 29. Among its related pathways are Chks in Checkpoint Regulation and Primary immunodeficiency. GO annotations related to this gene include uracil DNA N-glycosylase activity.
UniProtKB/Swiss-Prot for UNG Gene
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.