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UNCX Gene

protein-coding   GIFtS: 38
GCID: GC07P001272

UNC Homeobox

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UNC Homeobox1 2
Homeobox Protein Uncx4.12 3
UNCX4.12 3
Homeobox Protein Unc-4 Homolog2
Unc4.1 Homeobox2

External Ids:    HGNC: 331941   Entrez Gene: 3402602   Ensembl: ENSG000001648537   UniProtKB: A6NJT03   

Export aliases for UNCX gene to outside databases

Previous GC identifers: GC07P001241 GC07P001189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UNCX Gene:
UNCX (UNC homeobox) is a protein-coding gene. Diseases associated with UNCX include ventricular septal defect, and spina bifida. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSC.

UniProtKB/Swiss-Prot: UNC4_HUMAN, A6NJT0
Function: Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and
differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in
controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central
neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the UNCX gene promoter:
         SREBP-1c   CUTL1   NF-kappaB   SREBP-1b   N-Myc   SREBP-1a   NF-kappaB2   STAT3   NF-kappaB1   MRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UNCX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNCX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

UNCX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNCX gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P001272:  view genomic region     (about GC identifiers)

Start:
1,272,543 bp from pter      End:
1,276,954 bp from pter
Size:
4,412 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 1,325,450-1,343,496     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UNC4_HUMAN, A6NJT0 (See protein sequence)
Recommended Name: Homeobox protein unc-4 homolog  
Size: 531 amino acids; 53690 Da
Secondary accessions: A4D221

Explore the universe of human proteins at neXtProt for UNCX: NX_A6NJT0

Explore proteomics data for UNCX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UNCX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073930.1  
    ENSEMBL proteins: 
     ENSP00000314480  

    UNCX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for UNCX
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    Cloud-Clone Corp. Proteins for UNCX

    UNCX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for UNCX
    Novus Biologicals UNCX Antibodies
    Abcam antibodies for UNCX
    Cloud-Clone Corp. Antibodies for UNCX
    Search ThermoFisher Antibodies for UNCX
    LSBio Antibodies in human, mouse, rat for UNCX

    UNCX Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for UNCX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UNCX
    Cloud-Clone Corp. CLIAs for UNCX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRD: Homeoboxes / PRD class

    3 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry A6NJT0

    ProtoNet protein and cluster: A6NJT0

    UniProtKB/Swiss-Prot: UNC4_HUMAN, A6NJT0
    Similarity: Belongs to the paired homeobox family. Unc-4 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    UNCX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC4_HUMAN, A6NJT0
    Function: Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and
    differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in
    controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central
    neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    UNCX for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Uncx):
     growth/size/body  mortality/aging  nervous system  renal/urinary system  respiratory system 
     skeleton 

    UNCX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Uncxtm1Akis for UNCX

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UNCX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UNCX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UNCX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UNCX

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UNCX using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UNCX
    Predesigned siRNA for gene silencing in human, mouse, rat UNCX

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for UNCX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNCX (NM_001080461)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNCX
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UNCX

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for UNCX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNCX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UNC4_HUMAN, A6NJT0: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    UNCX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNCX
    Interactions:

        Search GeneGlobe Interaction Network for UNCX

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for UNCX (ENSP000003144804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2ENSP000003720234STRING: ENSP00000372023
    TLE1ENSP000003656824STRING: ENSP00000365682
    TLE3ENSP000003192334STRING: ENSP00000319233
    TLE4ENSP000003657354STRING: ENSP00000365735
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007389pattern specification process IEA--
    GO:0010468regulation of gene expression ----

    UNCX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNCX (UNC4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UNCX gene: 
    NM_001080461.1  

    Unigene Cluster for UNCX:

    UNC homeobox
    Hs.232272
    Unigene Representative Sequence: NM_001080461
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000316333(uc011jvw.2)
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UNCX
    Predesigned siRNA for gene silencing in human, mouse, rat UNCX
    Clone
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    OriGene clones in human, mouse for UNCX (see all 5)
    OriGene ORF clones in mouse, rat for UNCX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNCX (NM_001080461)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNCX
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UNCX
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UNCX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UNCX
      QuantiTect SYBR Green Assays in human, mouse, rat UNCX
      QuantiFast Probe-based Assays in human, mouse, rat UNCX

    1 DOTS entry:

    DT.99931508 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UNCX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCCGGAGG
    UNCX Expression
    About this image


    UNCX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Somite (Muscoskeletal System)    fully expand to see all 8 entries
             Sacral Somite Cells Sacral Somite
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Prechondrocytic Mesenchymal Cells Distal Rib
             Membranous Facial Bones
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Lumbar Sclerotome Cells Lumbar Mesenchymal Sclerotome
     
     Tendon & Ligament
             Lumbar Sclerotome Cells Lumbar Mesenchymal Sclerotome
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
             Cerebellum
    UNCX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNCX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.232272
        Custom PCR Arrays for UNCX
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UNCX
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNCX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UNCX gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uncx1 , 5 UNC homeobox1, 5 83.46(n)1
    85.63(a)1
      5 (78.75 cM)5
    222551  NM_013702.31  NP_038730.11 
     1395434945 
    chicken
    (Gallus gallus)
    Aves UNCX1 UNC homeobox 76.56(n)
    79.06(a)
      416458  XM_414766.4  XP_414766.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004920161 homeobox protein unc-4 homolog 67.85(n)
    71.86(a)
      100492016  XM_002938411.2  XP_002938457.1 
    zebrafish
    (Danio rerio)
    Actinopterygii uncx4.11 Unc4.1 homeobox (C. elegans) 70.91(n)
    81.27(a)
      553947  NM_001020780.2  NP_001018616.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta unc-46
    unc-4
    26(a)
    1 ↔ 1
    X(17663416-17674916)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-46
    Protein UNC-4 (unc-4) mRNA, complete cds
    29(a)
    1 ↔ 1
    II(9897754-9900257) WBGene00006744


    ENSEMBL Gene Tree for UNCX (if available)
    TreeFam Gene Tree for UNCX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UNCX gene
    GSC2  PITX12  OTX22  VSX12  HESX12  PITX22  VSX22  PROP12  
    PITX32  DMBX12  GSC22  CRX2  MIXL12  OTX12  
    1 SIMAP similar gene for UNCX using alignment to 1 protein entry:     UNC4_HUMAN:
    RAX2

    UNCX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UNCX (see all 107)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69503881,2
    C,F--1270699(+) ATAGAG/AACAGA 1 -- us2k19Minor allele frequency- A:0.44NA WA EA 370
    rs580639231,2
    C--1270738(+) TTGGCC/TTCTGA 1 -- us2k13Minor allele frequency- T:0.21NA EA 242
    rs1142125501,2
    F--1270810(+) AAATTC/TCAGGC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1122650651,2
    F--1271096(+) CTGACC/TCGGAG 1 -- us2k12Minor allele frequency- T:0.02CSA WA 120
    rs1412241191,2
    --1271133(+) CCTGCC/TCTTCC 1 -- us2k10--------
    rs1901331961,2
    --1271145(+) TCTCAA/CGCGGG 1 -- us2k10--------
    rs69511991,2
    C--1271148(+) CACGCA/GGGCTA 1 -- us2k10--------
    rs107087571,2
    C--1271234(+) GTGGCT/-CCGCA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs797989171,2
    F--1271399(+) TTTACA/GAAGGA 1 -- us2k10--------
    rs766621171,2
    --1271423(+) ACATCA/CCCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNCX (1272543 - 1276954 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UNCX (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673144CNV Deletion23128226
    nsv830876CNV Loss17160897
    esv23542CNV Loss19812545
    nsv830877CNV Loss17160897
    nsv887172CNV Loss21882294
    nsv887128CNV Loss21882294
    nsv887166CNV Loss21882294
    dgv7074n71CNV Loss21882294
    dgv7087n71CNV Loss21882294
    nsv887164CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UNCX
    DNA2.0 Custom Variant and Variant Library Synthesis for UNCX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for UNCX:    
    About MalaCards
    ventricular septal defect    spina bifida    cervicitis    cerebritis
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for UNCX:
    Ventricular septal defect     Spina bifida

    UNCX for disorders           About GeneDecksing


    Export disorders for UNCX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UNCX gene integrated from 10 sources:
    (articles sorted by number of sources associating them with UNCX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    3. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (Nat. Genet. 2012)
    4. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. (PubMed id 21897333)1 Irvin M.R....Arnett D.K. (Pharmacogenet. Genomics 2011)
    5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340260 HGNC: 33194 Ensembl:ENSG00000164853 euGenes: HUgn340260 ECgene: UNCX
    H-InvDB: UNCX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UNCX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UNCX gene:
    Search GeneIP for patents involving UNCX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UNCX  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UNCX  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UNCX  
     OriGene qSTAR qPCR primer pairs in human, mouse for UNCX   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UNCX   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UNCX   OriGene Custom Protein Services for UNCX  

     
     
     Block miRNA regulation of human, mouse, rat UNCX using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UNCX
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNCX Predesigned siRNA for gene silencing in human, mouse, rat UNCX
     QuantiFast Probe-based Assays in human, mouse, rat UNCX QuantiTect SYBR Green Assays in human, mouse, rat UNCX
     Custom PCR Arrays for UNCX Search Chromatin IP Primers for UNCX
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UNCX  Search GeneGlobe Interaction Network for UNCX
     Regulatory tfbs in UNCX promoter
     GenScript Custom Purified and Recombinant Proteins Services for UNCX GenScript cDNA clones with any tag delivered in your preferred vector for UNCX
     GenScript Custom Assay Services for UNCX GenScript Custom overexpressing Cell Line Services for UNCX
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
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     Search Tocris compounds for UNCX (UNC4)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Proteins for UNCX
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     Browse ESI BIO Cell Lines and PureStem Progenitors for UNCX
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNCX
     Browse SwitchGear 3'UTR luciferase reporter plasmids for UNCX
     Browse SwitchGear Promoter luciferase reporter plasmids for UNCX
     Search ThermoFisher Antibodies for UNCX
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UNCX
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UNCX
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UNCX
     LSBio Antibodies in human, mouse, rat for UNCX
    Customized transgenic rodents for:
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     Off-target effect monitoring
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     Tissue-specific gene expresssion
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     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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