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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNCX Gene

protein-coding   GIFtS: 36
GCID: GC07P001272

UNC homeobox
 Explore 4 diseases affiliated with
UNCX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UNCX    

Aliases
for UNCX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UNC Homeobox1 2
Homeobox Protein Uncx4.12 3
UNCX4.12 3
Uncx4.11
Homeobox Protein Unc-4 Homolog2
Unc4.1 Homeobox2

External Ids:    HGNC: 331941   Entrez Gene: 3402602   Ensembl: ENSG000001648537   UniProtKB: A6NJT03   

Export aliases for UNCX gene to outside databases

Previous GC identifers: GC07P001241 GC07P001189


Summaries
for UNCX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: UNC4_HUMAN, A6NJT0
Function: Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and
differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling
the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the
peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity)




Genomic Views
for UNCX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNCX gene promoter:
         SREBP-1c   CUTL1   NF-kappaB   SREBP-1b   N-Myc   SREBP-1a   NF-kappaB2   STAT3   NF-kappaB1   MRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UNCX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNCX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

UNCX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNCX gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P001272:  view genomic region     (about GC identifiers)

Start:
 1,272,543 bp from pter      End:
 1,276,954 bp from pter
Size:
 4,412 bases      Orientation:
 plus strand

Proteins
for UNCX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UNC4_HUMAN, A6NJT0 (See protein sequence)
Recommended Name: Homeobox protein unc-4 homolog  
Size: 531 amino acids; 53690 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A4D221

Explore the universe of human proteins at neXtProt for UNCX: NX_A6NJT0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NJT0

    • UNCX Protein expression data from MOPED and PaxDb:    About this image 
    UNCX Protein Expression
    REFSEQ proteins: NP_001073930.1  
    ENSEMBL proteins: 
     ENSP00000314480  

    Human Recombinant Protein Products for UNCX: 
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    Uscn Proteins for UNCX

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    UNCX for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UNCX

    Protein Domains /
    Families
    for UNCX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UNCX for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry A6NJT0

    ProtoNet protein and cluster: A6NJT0

    UniProtKB/Swiss-Prot: UNC4_HUMAN, A6NJT0
    Similarity: Belongs to the paired homeobox family. Unc-4 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for UNCX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC4_HUMAN, A6NJT0
    Function: Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and
    differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling
    the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the
    peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    UNCX for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Uncx):
     growth/size  mortality/aging  nervous system  renal/urinary system  respiratory system 
     skeleton 

    UNCX for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Uncxtm1Akis for UNCX
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UNCX 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNCX
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNCX (see all 4)
    OriGene shRNA RFP: UNCX
    OriGene siRNA: UNCX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNCX
    Sirion Biotech Custom design and validation of potent shRNA sequences against UNCX 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of UNCX 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNCX (see all 3)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UNCX (NM_001080461)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for UNCX

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UNCX


    Pathways & Interactions
    for UNCX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UNCX

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007389pattern specification process IEA--
    GO:0021516dorsal spinal cord development IEA--
    GO:0021889olfactory bulb interneuron differentiation IEA--

    UNCX for ontologies           About GeneDecksing



    Drugs & Compounds
    for UNCX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNCX
    Search CenterWatch for drugs/clinical trials and news about UNCX / UNC4 

    Transcripts
    for UNCX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UNCX gene: 
    NM_001080461.1  

    Unigene Cluster for UNCX:

    UNC homeobox
    Hs.232272
    Unigene Representative Sequence: NM_001080461
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000316333(uc011jvw.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNCX
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNCX (see all 4)
    OriGene shRNA RFP: UNCX
    OriGene siRNA: UNCX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNCX
    Sirion Biotech Custom design and validation of potent shRNA sequences against UNCX 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNCX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UNCX (NM_001080461)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNCX
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UNCX 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNCX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNCX

    1 DOTS entry:

    DT.99931508 

    GeneLoc Exon Structure


    Expression
    for UNCX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNCX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCCGGAGG
    UNCX Expression
    About this image

    UNCX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteCervical Mesenchymal SclerotomeCervical Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteCervical SomitesCervical Somite CellsSomite
    SomiteLumbar Mesenchymal SclerotomeLumbar Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteLumbar SomitesLumbar Somite CellsSmooth Muscle, Somite
    SomiteSacral SomitesSacral Somite CellsSmooth Muscle, Somite
    SomiteSomitesSomite CellsSmooth Muscle, Somite
    SomiteThoracic Distal RibPrechondrocytic Mesenchymal CellsBone, Cartilage
    SomiteThoracic Mesenchymal SclerotomeThoracic Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteThoracic SomitesThoracic Somite CellsSmooth Muscle, Somite
    Paraxial MesodermParaxial MesodermParaxial Mesoderm CellsMesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite

    See UNCX Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.232272
        SABiosciences Custom PCR Arrays for UNCX
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UNCX
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UNCX

    Orthologs
    for UNCX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UNCX gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UNCX1 UNC homeobox 74.63(n)
    76.78(a)    		   416458  XM_414766.3  XP_414766.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ARX6
    		 --
    		 17(a)
    		 1 ↔ 1
    		 3(126343374-126357272)
    zebrafish
    (Danio rerio)    		 Actinopterygii uncx4.11 Unc4.1 homeobox (C. elegans) 64.22(n)
    69.21(a)    		   553947  NM_001020780.2  NP_001018616.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta unc-46
    		 unc-4
    		 23(a)
    		 1 ↔ 1
    		 X(17663416-17674916)


    ENSEMBL Gene Tree for UNCX (if available)
    TreeFam Gene Tree for UNCX (if available) 

    Paralogs
    for UNCX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNCX gene
    ENSG000002585182  SHOX2  OTP2  SHOX22  
    2 SIMAP similar genes for UNCX using alignment to 1 protein entry:     UNC4_HUMAN:
    NKX6-1    RAX2

    UNCX for paralogs           About GeneDecksing



    Genomic Variants
    for UNCX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/78 NCBI SNPs in UNCX are shown (see all 78)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs69503881,2
    		C,F--1270699(+) ATAGAG/AACAGA 1 -- us2k19Minor allele frequency- A:0.44NA WA EA 370
    rs580639231,2
    		C--1270738(+) TTGGCC/TTCTGA 1 -- us2k13Minor allele frequency- T:0.21NA EA 242
    rs1142125501,2
    		--1270810(+) AAATTC/TCAGGC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1122650651,2
    		--1271096(+) CTGACC/TCGGAG 1 -- us2k12Minor allele frequency- T:0.02CSA WA 120
    rs1412241191,2
    		--1271133(+) CCTGCC/TCTTCC 1 -- us2k10--------
    rs1901331961,2
    		--1271145(+) TCTCAA/CGCGGG 1 -- us2k10--------
    rs69511991,2
    		C--1271148(+) CACGCA/GGGCTA 1 -- us2k10--------
    rs107087571,2
    		C--1271234(+) GTGGCT/-CCGCA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs797989171,2
    		--1271399(+) TTTACA/GAAGGA 1 -- us2k10--------
    rs766621171,2
    		--1271423(+) ACATCA/CCCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNCX (1272543 - 1276954 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for UNCX
         3 CNVs: 3660 4519 30248
         1 Indel: 69752

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNCX
    DNA2.0 Custom Variant and Variant Library Synthesis for UNCX

    Disorders / Diseases
    for UNCX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UNCX for disorders           About GeneDecksing

    4 diseases for UNCX:    About MalaCards
    double outlet right ventricle    spina bifida    pharyngitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for UNCX:
    Ventricular septal defect     Spina bifida

    Export disorders for UNCX gene to outside databases

    Publications
    for UNCX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNCX gene integrated from 9 sources:
    (articles sorted by number of sources associating them with UNCX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    3. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (2012)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    External Searches for UNCX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UNCX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340260 HGNC: 33194 Ensembl:ENSG00000164853 euGenes: HUgn340260 ECgene: UNCX
    H-InvDB: UNCX

    Other Databases showing UNCX gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UNCX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNCX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UNCX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UNCX gene:
    Search GeneIP for patents involving UNCX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for UNCX gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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