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Aliases for UNCX Gene

Aliases for UNCX Gene

  • UNC Homeobox 2 3
  • Homeobox Protein Uncx4.1 3 4
  • UNCX4.1 3 4
  • Homeobox Protein Unc-4 Homolog 3
  • Unc4.1 Homeobox 3

External Ids for UNCX Gene

Previous GeneCards Identifiers for UNCX Gene

  • GC07P001241
  • GC07P001189
  • GC07P001272

Summaries for UNCX Gene

GeneCards Summary for UNCX Gene

UNCX (UNC Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PITX3.

UniProtKB/Swiss-Prot for UNCX Gene

  • Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNCX Gene

Genomics for UNCX Gene

Regulatory Elements for UNCX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UNCX Gene

Start:
1,232,907 bp from pter
End:
1,237,318 bp from pter
Size:
4,412 bases
Orientation:
Plus strand

Genomic View for UNCX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNCX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNCX Gene

Proteins for UNCX Gene

  • Protein details for UNCX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJT0-UNC4_HUMAN
    Recommended name:
    Homeobox protein unc-4 homolog
    Protein Accession:
    A6NJT0
    Secondary Accessions:
    • A4D221

    Protein attributes for UNCX Gene

    Size:
    531 amino acids
    Molecular mass:
    53690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UNCX Gene

Proteomics data for UNCX Gene at MOPED

Post-translational modifications for UNCX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNCX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UNCX Gene

Domains for UNCX Gene

Gene Families for UNCX Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Protein Domains for UNCX Gene

Suggested Antigen Peptide Sequences for UNCX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NJT0

UniProtKB/Swiss-Prot:

UNC4_HUMAN :
  • A6NJT0
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family. Unc-4 subfamily.
genes like me logo Genes that share domains with UNCX: view

Function for UNCX Gene

Molecular function for UNCX Gene

UniProtKB/Swiss-Prot Function: Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).

Gene Ontology (GO) - Molecular Function for UNCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with UNCX: view
genes like me logo Genes that share phenotypes with UNCX: view

Animal Models for UNCX Gene

MGI Knock Outs for UNCX:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for UNCX Gene

Localization for UNCX Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNCX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNCX Gene COMPARTMENTS Subcellular localization image for UNCX gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for UNCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with UNCX: view

Pathways for UNCX Gene

SuperPathways for UNCX Gene

No Data Available

Interacting Proteins for UNCX Gene

Gene Ontology (GO) - Biological Process for UNCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007389 pattern specification process IEA --
GO:0010468 regulation of gene expression --
genes like me logo Genes that share ontologies with UNCX: view

No data available for Pathways by source for UNCX Gene

Transcripts for UNCX Gene

mRNA/cDNA for UNCX Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UNCX Gene

UNC homeobox:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNCX

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UNCX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNCX Gene

No ASD Table

Relevant External Links for UNCX Gene

GeneLoc Exon Structure for
UNCX
ECgene alternative splicing isoforms for
UNCX

Expression for UNCX Gene

mRNA expression in normal human tissues for UNCX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNCX Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (24.1) and Brain - Cerebellum (23.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UNCX Gene

SOURCE GeneReport for Unigene cluster for UNCX Gene Hs.232272

genes like me logo Genes that share expressions with UNCX: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UNCX Gene

Orthologs for UNCX Gene

This gene was present in the common ancestor of animals.

Orthologs for UNCX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 27 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia UNCX 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNCX 35
  • 87.14 (n)
  • 85.17 (a)
UNCX 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uncx 35
  • 83.46 (n)
  • 85.63 (a)
Uncx 16
Uncx 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNCX 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uncx 35
  • 83.01 (n)
  • 85.06 (a)
chicken
(Gallus gallus)
Aves UNCX 35
  • 76.56 (n)
  • 79.06 (a)
UNCX 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492016 35
  • 67.85 (n)
  • 71.86 (a)
zebrafish
(Danio rerio)
Actinopterygii uncx 36
  • 52 (a)
OneToMany
UNCX (3 of 3) 36
  • 37 (a)
OneToMany
uncx4.1 35
  • 70.91 (n)
  • 81.27 (a)
uncx4.1 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta unc-4 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-4 36
  • 29 (a)
OneToOne
Species with no ortholog for UNCX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNCX Gene

ENSEMBL:
Gene Tree for UNCX (if available)
TreeFam:
Gene Tree for UNCX (if available)

Paralogs for UNCX Gene

Paralogs for UNCX Gene

Selected SIMAP similar genes for UNCX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNCX: view

Variants for UNCX Gene

Sequence variations from dbSNP and Humsavar for UNCX Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2885341 -- 1,234,917(+) TTAAC(C/G)CGCCC intron-variant
rs4720671 -- 1,235,523(+) GACGC(C/T)CTCCG intron-variant
rs4724799 -- 1,234,946(+) TGCCC(A/G)AGCTT intron-variant
rs6950388 -- 1,231,063(+) ATAGA(A/G)ACAGA upstream-variant-2KB
rs6951199 -- 1,231,512(+) CACGC(A/G)GGCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UNCX Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
nsv887141 CNV Loss 21882294
dgv7087n71 CNV Loss 21882294
nsv830876 CNV Loss 17160897
nsv471182 CNV Loss 18288195
dgv2045e1 CNV Complex 17122850
nsv830877 CNV Loss 17160897
nsv887164 CNV Loss 21882294
dgv7088n71 CNV Loss 21882294
nsv887166 CNV Loss 21882294
nsv823961 CNV Gain 20364138
dgv1084n67 CNV Gain 20364138
dgv7089n71 CNV Loss 21882294
dgv7090n71 CNV Loss 21882294
dgv1085n67 CNV Gain 20364138
esv2673144 CNV Deletion 23128226
nsv887171 CNV Gain 21882294
nsv887172 CNV Loss 21882294
esv23542 CNV Loss 19812545

Relevant External Links for UNCX Gene

HapMap Linkage Disequilibrium report
UNCX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNCX Gene

Disorders for UNCX Gene

(2) University of Copenhagen DISEASES for UNCX Gene

genes like me logo Genes that share disorders with UNCX: view

No data available for UniProtKB/Swiss-Prot for UNCX Gene

Publications for UNCX Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. (PMID: 21897333) Irvin M.R. … Arnett D.K. (Pharmacogenet. Genomics 2011) 3
  4. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PMID: 22797727) Okada Y. … Tanaka T. (Nat. Genet. 2012) 3
  5. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3

Products for UNCX Gene

Sources for UNCX Gene

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