Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UNC93B1 Gene

protein-coding   GIFtS: 57
GCID: GC11M067759

Unc-93 Homolog B1 (C. Elegans)

(Previous name: unc93 (C. elegans) homolog B1)
  See UNC93B1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Unc-93 Homolog B1 (C. Elegans)1 2     Unc93 (C. Elegans) Homolog B11
UNC932 3     Protein Unc-93 Homolog B12
UNC93B2 3     Unc-93 Related Protein2
Unc-93B12 3     Unc93 Homolog B12
IIAE12 5     hUNC93B13

External Ids:    HGNC: 134811   Entrez Gene: 816222   Ensembl: ENSG000001100577   OMIM: 6082045   UniProtKB: Q9H1C43   

Export aliases for UNC93B1 gene to outside databases

Previous GC identifers: GC11M070281 GC11M069454 GC11M068008 GC11M067533 GC11M067515 GC11M064093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UNC93B1 Gene:
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like
receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from
the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex
encephalitis. (provided by RefSeq, Feb 2014)

GeneCards Summary for UNC93B1 Gene:
UNC93B1 (unc-93 homolog B1 (C. elegans)) is a protein-coding gene. Diseases associated with UNC93B1 include herpes simplex encephalitis 1, and encephalitis. An important paralog of this gene is ENSG00000233094.

UniProtKB/Swiss-Prot: UN93B_HUMAN, Q9H1C4
Function: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like
receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the
endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling
cascades. May play a role in autoreactive B-cells removal

Gene Wiki entry for UNC93B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UNC93B1 gene promoter:
         AML1a   Pax-5   MIF-1   E47   Egr-2   POU2F1   HOXA5   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC93B1 promoter sequence
   Search Chromatin IP Primers for UNC93B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNC93B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

UNC93B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC93B1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067759:  view genomic region     (about GC identifiers)

Start:
67,758,575 bp from pter      End:
67,772,452 bp from pter
Size:
13,878 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UN93B_HUMAN, Q9H1C4 (See protein sequence)
Recommended Name: Protein unc-93 homolog B1  
Size: 597 amino acids; 66631 Da
Subunit: Interacts with TLR3, TLR7, and TLR9 (probably via transmembrane domain) (By similarity)
Sequence caution: Sequence=AAD15416.1; Type=Erroneous gene model prediction;
Secondary accessions: O95764 Q569H6 Q710D4

Explore the universe of human proteins at neXtProt for UNC93B1: NX_Q9H1C4

Explore proteomics data for UNC93B1 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Ubiquitination2 at Lys333
  • Glycosylation2 at Asn251, Asn272, Asn449
  • Modification sites at PhosphoSitePlus

  • See UNC93B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112192.2  
    ENSEMBL proteins: 
     ENSP00000434294   ENSP00000437195   ENSP00000436758   ENSP00000227471  
    Reactome Protein details: Q9H1C4

    UNC93B1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UNC93B1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UNC93B1
    GenScript Custom Purified and Recombinant Proteins Services for UNC93B1
    Novus Biologicals UNC93B1 Proteins
    Novus Biologicals UNC93B1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UNC93B1

     
    Search eBioscience for Proteins for UNC93B1 

    UNC93B1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UNC93B1
    OriGene Custom Antibody Services for UNC93B1
    Novus Biologicals UNC93B1 Antibodies
    Abcam antibodies for UNC93B1
    Cloud-Clone Corp. Antibodies for UNC93B1
    ThermoFisher Antibodies for UNC93B1
    LSBio Antibodies in human, mouse, rat for UNC93B1

    UNC93B1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UNC93B1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UNC93B1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UNC93B1
    Cloud-Clone Corp. CLIAs for UNC93B1
    Search eBioscience for ELISAs for UNC93B1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR010291 Ion_channel_UNC-93

    Graphical View of Domain Structure for InterPro Entry Q9H1C4

    ProtoNet protein and cluster: Q9H1C4

    UniProtKB/Swiss-Prot: UN93B_HUMAN, Q9H1C4
    Similarity: Belongs to the unc-93 family


    Find genes that share domains with UNC93B1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UN93B_HUMAN, Q9H1C4
    Function: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like
    receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the
    endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling
    cascades. May play a role in autoreactive B-cells removal
    Induction: Up-regulated by TLRs agonists

    Phenotypes:
         1 GenomeRNAi human phenotype for UNC93B1:

     Decreased viability with pacli 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Unc93b1):
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     renal/urinary system  skeleton 

    Find genes that share phenotypes with UNC93B1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UNC93B1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UNC93B1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UNC93B1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UNC93B1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UNC93B1:
    hsa-mir-335-5p (MIRT018906), hsa-mir-1 (MIRT001323), hsa-mir-26b-5p (MIRT030095)

    Block miRNA regulation of human, mouse, rat UNC93B1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate UNC93B1:
    hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmidUNC93B1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UNC93B1
    Predesigned siRNA for gene silencing in human, mouse, rat UNC93B1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UNC93B1

    Clone
    Products:
         
    OriGene clones in human, mouse for UNC93B1 (see all 8)
    OriGene ORF clones in mouse, rat for UNC93B1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNC93B1 (NM_030930)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC93B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC93B1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UNC93B1
    Browse ESI BIO Cell Lines and PureStem Progenitors for UNC93B1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC93B1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UN93B_HUMAN, Q9H1C4: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endosome (By
    similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity). Note=Relocalizes from
    endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity).
    Colocalizes with LAMP5 in large endosomal intracellular vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    golgi apparatus4
    lysosome4
    vacuole4
    plasma membrane3
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005764lysosome ISS--
    GO:0005768endosome ISS--
    GO:0005783endoplasmic reticulum IDA18082565
    GO:0005789endoplasmic reticulum membrane TAS--

    Find genes that share ontologies with UNC93B1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UNC93B1 About    
    See pathways by source

    SuperPathContained pathways About
    1Trafficking and processing of endosomal TLR
    Trafficking and processing of endosomal TLR


    Find genes that share SuperPaths with UNC93B1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for UNC93B1
        Trafficking and processing of endosomal TLR


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNC93B1
    Interactions:

        Search GeneGlobe Interaction Network for UNC93B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UNC93B1 (Q9H1C43 ENSP000002274714) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANKHD1Q8IWZ33, ENSP000002971834I2D: score=1 STRING: ENSP00000297183
    CCDC47Q96A333, ENSP000002257264I2D: score=1 STRING: ENSP00000225726
    CLPTM1O960053, ENSP000003369944I2D: score=1 STRING: ENSP00000336994
    DDOSTP396563, ENSP000003641884I2D: score=1 STRING: ENSP00000364188
    FARSAQ9Y2853, ENSP000003203094I2D: score=1 STRING: ENSP00000320309
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0006886intracellular protein transport ISS--
    GO:0034138toll-like receptor 3 signaling pathway IMP18082565
    GO:0034154toll-like receptor 7 signaling pathway IMP19006693
    GO:0034162toll-like receptor 9 signaling pathway IMP19006693

    Find genes that share ontologies with UNC93B1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNC93B1 (UN93B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UNC93B1 gene: 
    NM_030930.3  

    Unigene Cluster for UNC93B1:

    Unc-93 homolog B1 (C. elegans)
    Hs.502989  [show with all ESTs]
    Unigene Representative Sequence: NM_030930
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533966 ENST00000530331 ENST00000525368 ENST00000525743 ENST00000533424
    ENST00000524455 ENST00000528423 ENST00000528096 ENST00000530138 ENST00000531152
    ENST00000227471(uc001omw.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UNC93B1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate UNC93B1:
    hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmidUNC93B1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UNC93B1
    Predesigned siRNA for gene silencing in human, mouse, rat UNC93B1
    Clone
    Products:
         
    OriGene clones in human, mouse for UNC93B1 (see all 8)
    OriGene ORF clones in mouse, rat for UNC93B1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNC93B1 (NM_030930)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC93B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC93B1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UNC93B1
    OriGene qSTAR qPCR primer pairs in human, mouse for UNC93B1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UNC93B1
      QuantiTect SYBR Green Assays in human, mouse, rat UNC93B1
      QuantiFast Probe-based Assays in human, mouse, rat UNC93B1

    Additional mRNA sequence: 

    AJ271326.1 AJ422142.1 AY007125.1 BC025669.1 BC033623.1 BC092472.1 BC101568.1 BC105104.1 

    12 DOTS entries:

    DT.100839527  DT.95291731  DT.97854662  DT.95364316  DT.200613  DT.100822082  DT.91805027  DT.112377 
    DT.120727139  DT.121047962  DT.121235726  DT.95116171 

    Selected AceView cDNA sequences (see all 341):

    AW295691 BI905908 AA481285 CA308331 BI906483 BQ072767 AI278282 BE675080 
    BC025669 AI367019 AA250809 AW402891 BM767594 BM563622 CA424450 AA730281 
    BQ073179 BM921125 BM741763 AI378246 BM973063 BE501187 BM717491 BI916186 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UNC93B1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11
    SP1:                          -     -           -                       -                                             
    SP2:                                            -                       -                                             
    SP3:                                                                    -                                             
    SP4:        -     -     -     -     -           -                       -                                             
    SP5:                                -           -                       -                                             


    ECgene alternative splicing isoforms for UNC93B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UNC93B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGACGGCGC
    UNC93B1 Expression
    About this image

    UNC93B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNC93B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502989

    UniProtKB/Swiss-Prot: UN93B_HUMAN, Q9H1C4
    Tissue specificity: Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in
    antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other
    tissues

        Custom PCR Arrays for UNC93B1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UNC93B1
    OriGene qSTAR qPCR primer pairs in human, mouse for UNC93B1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UNC93B1
    QuantiTect SYBR Green Assays in human, mouse, rat UNC93B1
    QuantiFast Probe-based Assays in human, mouse, rat UNC93B1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC93B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for UNC93B1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc93b11 , 5 unc-93 homolog B1 (C. elegans)1, 5 84.53(n)1
    89.78(a)1
      19 (3.65 cM)5
    544451  NM_019449.21  NP_062322.21 
     39351865 
    chicken
    (Gallus gallus)
    Aves UNC93B11 unc-93 homolog B1 (C. elegans) 75.6(n)
    71.1(a)
      395244  XM_004941265.1  XP_004941322.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    66(a)
    1 → many
    1(93594217-93627357)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia unc93b11 unc-93 homolog B1 60.76(n)
    62.31(a)
      100101743  NM_001100253.1  NP_001093723.1 
    zebrafish
    (Danio rerio)
    Actinopterygii unc93b11 unc-93 homolog B1 (C. elegans) 65.1(n)
    62.96(a)
      100000934  XM_002660536.3  XP_002660582.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49286
    CG21216
    --
    19(a)
    16(a)
    many ↔ many
    many ↔ many
    X(16807231-16831444)
    2R(4283898-4299228)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-936
    Protein UNC-93, isoform a
    13(a)
    1 → many
    III(3644375-3648822) WBGene00006822


    ENSEMBL Gene Tree for UNC93B1 (if available)
    TreeFam Gene Tree for UNC93B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UNC93B1 gene
    ENSG000002330942  UNC93A2  
    1 SIMAP similar gene for UNC93B1 using alignment to 6 protein entries:     UN93B_HUMAN (see all proteins):
    UNC93A

    Find genes that share paralogs with UNC93B1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UNC93B1 (see all 419)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828272281,2
    --67679719(+) CAGGCA/CTCTGG 1 -- ds50010--------
    rs1475826351,2
    --67680031(+) GCATCC/TGTGCA 1 -- ds50010--------
    rs108962851,2
    C,A,H--67680266(+) CCGCGG/TGGTTT 1 -- ut31 ese32Minor allele frequency- T:0.02MN NA 186
    rs1828403331,2
    --67680273(+) GTTTCA/CGCTGT 1 -- ut310--------
    rs746380041,2
    C--67680431(+) GGACTA/CGGAGG 1 -- ut310--------
    rs40145801,2
    --67680452(-) CGTCTG/TAGGTC 1 -- ut31 ese30--------
    rs23751821,2
    C--67680538(-) CGCAGA/G/TGGGGA 3 R G W mis1 ese3 trp30--------
    rs23751781,2
    C--67680691(-) GCGGTG/TACCGC 2 D Y mis1 ese30--------
    rs71491,2
    C,F--67680749(-) CTGCGG/CCGGGG 2 /R syn1 ese32Minor allele frequency- C:0.04NA MN 186
    rs40145961,2
    C--67680811(-) TGGCGG/ATGCTG 2 /M /V mis11Minor allele frequency- A:0.01EU 109

    HapMap Linkage Disequilibrium report for UNC93B1 (67758575 - 67772452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UNC93B1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1205n71CNV Loss21882294
    nsv469964CNV Loss18288195
    nsv897839CNV Loss21882294
    dgv1203n71CNV Loss21882294
    nsv468615CNV Loss19166990
    dgv156n27CNV Loss19166990
    dgv1204n71CNV Loss21882294
    nsv825963CNV Gain20364138
    nsv482160CNV Gain20164927
    nsv8836CNV Gain18304495

    Human Gene Mutation Database (HGMD): UNC93B1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC93B1
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC93B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608204   
    OMIM disorders: 610551  
    UniProtKB/Swiss-Prot: UN93B_HUMAN, Q9H1C4
  • Herpes simplex encephalitis 1 (HSE1) [MIM:610551]: A rare complication of human herpesvirus 1 (HHV-1)
    infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic
    necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache,
    seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry. Mutations in UNC93B1 resulting in autosomal recessive
    UNC93B1 deficieny predispose otherwise healthy individuals to isolated herpes simplex encephalitis due to
    impaired IFNs production. UNC93B1 deficieny, however, does not compromise immunity to most pathogens, unlike most
    known primary immunodeficiencies

  • 5 diseases for UNC93B1:    
    About MalaCards
    herpes simplex encephalitis 1    encephalitis    herpes simplex    herpes simplex encephalitis
    melkersson-rosenthal syndrome

    3 diseases from the University of Copenhagen DISEASES database for UNC93B1:
    Encephalitis     Herpes simplex     Melkersson-Rosenthal syndrome

    Find genes that share disorders with UNC93B1           About GenesLikeMe


    Export disorders for UNC93B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UNC93B1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with UNC93B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein. (PubMed id 11867227)1, 2, 3, 9 Kashuba V.I.... Zabarovsky E.R. (Gene 2002)
    2. Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response. (PubMed id 18082565)1, 2, 9 Koehn J.... Korthaeuer U. (Hum. Immunol. 2007)
    3. IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. (PubMed id 19006693)1, 2 Isnardi I.... Meffre E. (Immunity 2008)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    5. Herpes simplex virus encephalitis in human UNC-93B deficiency. (PubMed id 16973841)1, 2 Casrouge A....Casanova J.-L. (Science 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Trafficking of endosomal Toll-like receptors. (PubMed id 24439965)1 Lee B.L. and Barton G.M. (Trends Cell Biol. 2014)
    8. The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. (PubMed id 23166319)1 Pohar J....Jerala R. (J. Biol. Chem. 2013)
    9. IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients. (PubMed id 23002119)1 Weller S....Reynaud C.A. (Blood 2012)
    10. Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling. (PubMed id 22611194)1 Garcia-Cattaneo A....Benaroch P. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 81622 HGNC: 13481 AceView: UNC93B1 Ensembl:ENSG00000110057 euGenes: HUgn81622
    ECgene: UNC93B1 H-InvDB: UNC93B1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UNC93B1 Pharmacogenomics, SNPs, Pathways
    UNC93B1basehttp://bioinf.uta.fi/UNC93B1base/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UNC93B1 gene:
    Search GeneIP for patents involving UNC93B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UNC93B1   OriGene RNAi products in human, mouse, rat for UNC93B1  
     OriGene qPCR primer pairs and template standards for UNC93B1   OriGene Protein Over-expression Lysate for UNC93B1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UNC93B1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UNC93B1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UNC93B1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UNC93B1   OriGene Custom Protein Services for UNC93B1  

     
     
     Block miRNA regulation of human, mouse, rat UNC93B1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UNC93B1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNC93B1 Predesigned siRNA for gene silencing in human, mouse, rat UNC93B1
     QuantiFast Probe-based Assays in human, mouse, rat UNC93B1 QuantiTect SYBR Green Assays in human, mouse, rat UNC93B1
     Custom PCR Arrays for UNC93B1 Search Chromatin IP Primers for UNC93B1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UNC93B1  Search GeneGlobe Interaction Network for UNC93B1
     Regulatory tfbs in UNC93B1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UNC93B1 GenScript cDNA clones with any tag delivered in your preferred vector for UNC93B1
     GenScript Custom Assay Services for UNC93B1 GenScript Custom overexpressing Cell Line Services for UNC93B1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UNC93B1 (UN93B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UNC93B1 antibodies
     UNC93B1 proteins
     UNC93B1 lysates
     Antibodies for UNC93B1
     See all of Abcam's Antibodies, Kits and Proteins for UNC93B1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UNC93B1
     Antibodies for UNC93B1
     ELISAs for UNC93B1
     CLIAs for UNC93B1



     Browse ESI BIO Cell Lines and PureStem Progenitors for UNC93B1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC93B1
     SwitchGear 3'UTR luciferase reporter plasmids for UNC93B1
     SwitchGear Promoter luciferase reporter plasmids for UNC93B1
     ThermoFisher Antibodies for UNC93B1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC93B1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UNC93B1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UNC93B1
     LSBio Antibodies in human, mouse, rat for UNC93B1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for UNC93B1
      Search eBioscience for proteins for UNC93B1
      Search eBioscience for elisas for UNC93B1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UNC93B1 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4