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UNC93A Gene

protein-coding   GIFtS: 48
GCID: GC06P167704

Unc-93 Homolog A (C. Elegans)

(Previous name: unc93 (C.elegans) homolog A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-93 Homolog A (C. Elegans)1 2     DJ366N23.1 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) LIKE)2
Unc-93A2 3     DJ366N23.2 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) C-Terminal
LIKE)2
Unc93 (C.Elegans) Homolog A1     Protein Unc-93 Homolog A2
dJ366N23.12     Unc93 Homolog A2
dJ366N23.22     HmUnc-93A3

External Ids:    HGNC: 125701   Entrez Gene: 543462   Ensembl: ENSG000001124947   OMIM: 6079955   UniProtKB: Q86WB73   

Export aliases for UNC93A gene to outside databases

Previous GC identifers: GC06P167058 GC06P167578 GC06P167614 GC06P167675 GC06P167624 GC06P165177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UNC93A Gene:
UNC93A (unc-93 homolog A (C. elegans)) is a protein-coding gene. Diseases associated with UNC93A include ovarian cancer, and malaria. An important paralog of this gene is ENSG00000233094.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for UNC93A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC93A promoter sequence
   Search Chromatin IP Primers for UNC93A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNC93A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

UNC93A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC93A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P167704:  view genomic region     (about GC identifiers)

Start:
167,684,657 bp from pter      End:
167,729,507 bp from pter
Size:
44,851 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UN93A_HUMAN, Q86WB7 (See protein sequence)
Recommended Name: Protein unc-93 homolog A  
Size: 457 amino acids; 50270 Da
Miscellaneous: Although UNC93A gene is located in a region of the genome frequently associated with ovarian
cancer, no evidence have been found for a tumor suppressor function
Sequence caution: Sequence=CAI42706.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KRP5 Q4QQJ4 Q5JZD6
Alternative splicing: 2 isoforms:  Q86WB7-1   Q86WB7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNC93A: NX_Q86WB7

Explore proteomics data for UNC93A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn190

  • See UNC93A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137419.1  NP_061847.2  

    ENSEMBL proteins: 
     ENSP00000421484   ENSP00000230256   ENSP00000355794  

    UNC93A Human Recombinant Protein Products:

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    UNC93A Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010291 Ion_channel_UNC-93
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q86WB7

    ProtoNet protein and cluster: Q86WB7

    UniProtKB/Swiss-Prot: UN93A_HUMAN, Q86WB7
    Similarity: Belongs to the unc-93 family


    UNC93A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    UNC93A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UNC93A
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate UNC93A:
    hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidUNC93A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UNC93A

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    GenScript: all cDNA clones in your preferred vector (see all 2): UNC93A (NM_001143947)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UN93A_HUMAN, Q86WB7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA12381271
    GO:0016021integral component of membrane NAS12381271

    UNC93A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNC93A
    Interactions:

        Search GeneGlobe Interaction Network for UNC93A

    2 Interacting proteins for UNC93A (Q86WB73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS9O001823I2D: score=2 
    FGFR3P226073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    UNC93A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNC93A (UN93A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UNC93A gene (2 alternative transcripts): 
    NM_001143947.1  NM_018974.3  

    Unigene Cluster for UNC93A:

    Unc-93 homolog A (C. elegans)
    Hs.567508  [show with all ESTs]
    Unigene Representative Sequence: NM_018974
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503433 ENST00000230256(uc003qvq.3 uc003qvr.3) ENST00000366830
    ENST00000366829 ENST00000504706
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate UNC93A:
    hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidUNC93A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UNC93A
    Predesigned siRNA for gene silencing in human, mouse, rat UNC93A
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    GenScript: all cDNA clones in your preferred vector (see all 2): UNC93A (NM_001143947)
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat UNC93A

    Additional mRNA sequence: 

    AJ422141.1 AJ508812.1 AK091987.1 BC098248.1 BC099718.1 BC105635.1 

    3 DOTS entries:

    DT.40284045  DT.97839430  DT.111672 

    Selected AceView cDNA sequences (see all 39):

    AX747293 AJ422141 NM_018974 H47279 R16618 AK091987 AJ508812 BM784293 
    BM783623 BG215813 AA702150 BV184724 AI831447 CB113328 AI191713 BM746467 
    BM745638 BM753122 R16560 BM783448 BM748114 AI655386 BM753637 W92075 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC93A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:                                          
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for UNC93A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UNC93A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UNC93A Expression
    About this image

    UNC93A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNC93A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567508

    UniProtKB/Swiss-Prot: UN93A_HUMAN, Q86WB7
    Tissue specificity: Expressed in testis, small intestine, spleen, prostate and ovary

        Custom PCR Arrays for UNC93A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC93A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UNC93A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc93a5
    Gm99921
    unc-93 homolog A (C. elegans)5
    predicted gene 99921
    76.24(n)1
    72.59(a)1
      17 (8.78 cM)5
    6670551  NM_001142539.11  NP_001136011.11 
     131086175 
    chicken
    (Gallus gallus)
    Aves UNC93A6
    unc-93 homolog A (C. elegans)
    64(a)
    1 ↔ 1
    3(41687479-41708127)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    63(a)
    62(a)
    1 ↔ many
    1 ↔ many
    1(225476371-225489524)
    1(225317209-225373208)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.133742 Transcribed sequence with weak similarity to protein more 70.54(n)    BX730375.1 
    zebrafish
    (Danio rerio)
    Actinopterygii unc93a1 unc-93 homolog A (C. elegans) 62.2(n)
    58.9(a)
      559995  NM_001044916.1  NP_001038381.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49281 CG4928 52.74(n)
    41.56(a)
      32682  NM_167552.1  NP_728035.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-931 unc-93 45.96(n)
    34.41(a)
      175466  NM_001026047.4  NP_001021218.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G094701 AT3G09470 44.47(n)
    31.58(a)
      820104  NM_180215.3  NP_850546.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g05669001 Os12g0566900 45.12(n)
    32.07(a)
      4352555  NM_001073590.1  NP_001067058.1 


    ENSEMBL Gene Tree for UNC93A (if available)
    TreeFam Gene Tree for UNC93A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UNC93A gene
    ENSG000002330942  UNC93B12  
    1 SIMAP similar gene for UNC93A using alignment to 2 protein entries:     UN93A_HUMAN (see all proteins):
    UNC93B1

    UNC93A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UNC93A
    PGOHUM00000243456


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UNC93A (see all 939)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1511803621,2
    C--167702878(+) GAAATA/GTACTG 2 -- us2k10--------
    rs4379141,2
    --167702884(+) TACTGG/TTCATT 2 -- us2k1 tfbs30--------
    rs1126335521,2
    C--167702890(+) CATTT-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs4379221,2
    --167702906(+) CCTTTG/TAACAT 2 -- us2k1 tfbs30--------
    rs1888414821,2
    C--167703125(+) AAACAA/GCCCCC 2 -- us2k10--------
    rs624384841,2
    C--167703253(+) CATCCG/ATGGGA 2 -- us2k15Minor allele frequency- A:0.00NA WA 10
    rs350270301,2
    C--167703332(+) TTGATC/TGATAA 2 -- us2k10--------
    rs3887881,2
    --167703362(+) TCCACA/GTTATG 2 -- us2k10--------
    rs3888071,2
    C,F--167703381(+) TTTACA/GTATTA 2 -- us2k111Minor allele frequency- G:0.49NA EA 172
    rs3743121,2
    C,F,A,H--167703390(+) TATTCC/TAATTT 2 -- us2k1 tfbs38Minor allele frequency- T:0.14NA WA CSA 14

    HapMap Linkage Disequilibrium report for UNC93A (167684657 - 167729507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UNC93A (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1081e201CNV Deletion23290073
    esv2733230CNV Deletion23290073
    esv2733231CNV Deletion23290073
    nsv509170CNV Insertion20534489
    nsv464145CNV Loss19166990
    nsv886946CNV Loss21882294
    nsv886945CNV Loss21882294
    nsv470873CNV Gain18288195
    nsv886944CNV Gain21882294
    nsv464141CNV Gain19166990

    Human Gene Mutation Database (HGMD): UNC93A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC93A
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC93A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607995    OMIM disorders: --

    3 diseases for UNC93A:    
    About MalaCards
    ovarian cancer    malaria    prostatitis


    UNC93A for disorders           About GeneDecksing


    Export disorders for UNC93A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UNC93A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with UNC93A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer. (PubMed id 12381271)1, 2, 3, 9 Liu Y.... Ganesan T.S. (BMC Genet. 2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54346 HGNC: 12570 AceView: UNC93A Ensembl:ENSG00000112494 euGenes: HUgn54346
    ECgene: UNC93A H-InvDB: UNC93A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UNC93A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UNC93A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UNC93A gene:
    Search GeneIP for patents involving UNC93A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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