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Aliases for UNC93A Gene

Aliases for UNC93A Gene

  • Unc-93 Homolog A (C. Elegans) 2 3
  • Unc-93A 3 4
  • DJ366N23.2 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) C-Terminal LIKE) 3
  • DJ366N23.1 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) LIKE) 3
  • Unc93 (C.Elegans) Homolog A 2
  • Protein Unc-93 Homolog A 3
  • Unc93 Homolog A 3
  • DJ366N23.1 3
  • DJ366N23.2 3
  • HmUnc-93A 4

External Ids for UNC93A Gene

Previous GeneCards Identifiers for UNC93A Gene

  • GC06P167058
  • GC06P167578
  • GC06P167614
  • GC06P167675
  • GC06P167624
  • GC06P167704
  • GC06P165177

Summaries for UNC93A Gene

GeneCards Summary for UNC93A Gene

UNC93A (Unc-93 Homolog A (C. Elegans)) is a Protein Coding gene. An important paralog of this gene is UNC93B1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC93A Gene

Genomics for UNC93A Gene

Genomic Location for UNC93A Gene

Start:
167,271,169 bp from pter
End:
167,316,019 bp from pter
Size:
44,851 bases
Orientation:
Plus strand

Genomic View for UNC93A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNC93A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC93A Gene

No data available for Regulatory Elements for UNC93A Gene

Proteins for UNC93A Gene

  • Protein details for UNC93A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WB7-UN93A_HUMAN
    Recommended name:
    Protein unc-93 homolog A
    Protein Accession:
    Q86WB7
    Secondary Accessions:
    • B3KRP5
    • Q4QQJ4
    • Q5JZD6

    Protein attributes for UNC93A Gene

    Size:
    457 amino acids
    Molecular mass:
    50270 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function
    SequenceCaution:
    • Sequence=CAI42706.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UNC93A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC93A Gene

Proteomics data for UNC93A Gene at MOPED

Post-translational modifications for UNC93A Gene

Other Protein References for UNC93A Gene

No data available for DME Specific Peptides for UNC93A Gene

Domains for UNC93A Gene

Protein Domains for UNC93A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UNC93A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WB7

UniProtKB/Swiss-Prot:

UN93A_HUMAN :
  • Q86WB7
Family:
  • Belongs to the unc-93 family.
genes like me logo Genes that share domains with UNC93A: view

No data available for Gene Families for UNC93A Gene

Function for UNC93A Gene

Gene Ontology (GO) - Molecular Function for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with UNC93A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UNC93A Gene

Localization for UNC93A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC93A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC93A Gene COMPARTMENTS Subcellular localization image for UNC93A gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 12381271
GO:0016021 integral component of membrane NAS 12381271
genes like me logo Genes that share ontologies with UNC93A: view

Pathways for UNC93A Gene

SuperPathways for UNC93A Gene

No Data Available

Interacting Proteins for UNC93A Gene

Selected Interacting proteins: Q86WB7-UN93A_HUMAN for UNC93A Gene via I2D

Symbol External ID(s) Details
FGFR3
LGALS9

Gene Ontology (GO) - Biological Process for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with UNC93A: view

No data available for Pathways by source for UNC93A Gene

Transcripts for UNC93A Gene

Unigene Clusters for UNC93A Gene

Unc-93 homolog A (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC93A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3:

Relevant External Links for UNC93A Gene

GeneLoc Exon Structure for
UNC93A
ECgene alternative splicing isoforms for
UNC93A

Expression for UNC93A Gene

mRNA expression in normal human tissues for UNC93A Gene

mRNA differential expression in normal tissues according to GTEx for UNC93A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (20.8), Skin - Not Sun Exposed (Suprapubic) (14.4), and Liver (9.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for UNC93A Gene

SOURCE GeneReport for Unigene cluster for UNC93A Gene Hs.567508

mRNA Expression by UniProt/SwissProt for UNC93A Gene

Q86WB7-UN93A_HUMAN
Tissue specificity: Expressed in testis, small intestine, spleen, prostate and ovary.
genes like me logo Genes that share expressions with UNC93A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UNC93A Gene

Orthologs for UNC93A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UNC93A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC93A 35
  • 98.91 (n)
  • 98.69 (a)
UNC93A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC93A 35
  • 78.34 (n)
  • 74.4 (a)
UNC93A 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC93A 35
  • 82.09 (n)
  • 80.7 (a)
UNC93A 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm8597 36
  • 46 (a)
OneToMany
Gm9992 35
  • 76.24 (n)
  • 72.59 (a)
Gm9992 36
  • 71 (a)
OneToMany
Unc93a 16
Unc93a 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UNC93A 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc93a 35
  • 75.26 (n)
  • 72.47 (a)
chicken
(Gallus gallus)
Aves UNC93A 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487981 35
  • 61.1 (n)
  • 59.95 (a)
Str.13374 35
zebrafish
(Danio rerio)
Actinopterygii unc93a 35
  • 62.2 (n)
  • 58.9 (a)
unc93a 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000834 35
  • 52.23 (n)
  • 41.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2121 36
  • 26 (a)
ManyToMany
CG4928 35
  • 52.74 (n)
  • 41.56 (a)
CG4928 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-93 35
  • 45.96 (n)
  • 34.41 (a)
unc-93 36
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09470 35
  • 44.47 (n)
  • 31.58 (a)
rice
(Oryza sativa)
Liliopsida Os12g0566900 35
  • 45.12 (n)
  • 32.07 (a)
Species with no ortholog for UNC93A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC93A Gene

ENSEMBL:
Gene Tree for UNC93A (if available)
TreeFam:
Gene Tree for UNC93A (if available)

Paralogs for UNC93A Gene

Paralogs for UNC93A Gene

Selected SIMAP similar genes for UNC93A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for UNC93A Gene

genes like me logo Genes that share paralogs with UNC93A: view

Variants for UNC93A Gene

Sequence variations from dbSNP and Humsavar for UNC93A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2054 -- 167,303,635(+) GGGGT(C/T)GCTCC intron-variant
rs374312 -- 167,289,902(+) TATTC(C/T)AATTT upstream-variant-2KB
rs387155 -- 167,316,011(+) TTTAA(C/T)GGACT utr-variant-3-prime
rs388788 -- 167,289,874(+) TCCAC(A/G)TTATG upstream-variant-2KB
rs388807 -- 167,289,893(+) TTTAC(A/G)TATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UNC93A Gene

Variant ID Type Subtype PubMed ID
essv22845 CNV CNV 17122850
dgv2033e1 CNV Complex 17122850
nsv464141 CNV Gain 19166990
nsv470873 CNV Gain 18288195
nsv7389 OTHER Inversion 18451855
nsv886944 CNV Gain 21882294
esv24545 CNV Gain+Loss 19812545
dgv1081e201 CNV Deletion 23290073
esv34252 CNV Gain 17911159
nsv509170 CNV Insertion 20534489
nsv886945 CNV Loss 21882294
nsv886946 CNV Loss 21882294
esv2733230 CNV Deletion 23290073
nsv517210 CNV Gain+Loss 19592680
nsv886947 CNV Gain 21882294
esv2733231 CNV Deletion 23290073
nsv464145 CNV Loss 19166990

Relevant External Links for UNC93A Gene

HapMap Linkage Disequilibrium report
UNC93A
Human Gene Mutation Database (HGMD)
UNC93A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC93A Gene

Disorders for UNC93A Gene

No disorders were found for UNC93A Gene.

No data available for UniProtKB/Swiss-Prot for UNC93A Gene

Publications for UNC93A Gene

  1. The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer. (PMID: 12381271) Liu Y. … Ganesan T.S. (BMC Genet. 2002) 2 3 4 23
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for UNC93A Gene

Sources for UNC93A Gene

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