Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UNC93A Gene

Aliases for UNC93A Gene

  • Unc-93 Homolog A (C. Elegans) 2 3 5
  • Unc-93A 3 4
  • DJ366N23.2 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) C-Terminal LIKE) 3
  • DJ366N23.1 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) LIKE) 3
  • Unc93 (C.Elegans) Homolog A 2
  • Protein Unc-93 Homolog A 3
  • Unc93 Homolog A 3
  • DJ366N23.1 3
  • DJ366N23.2 3
  • HmUnc-93A 4

External Ids for UNC93A Gene

Previous GeneCards Identifiers for UNC93A Gene

  • GC06P167058
  • GC06P167578
  • GC06P167614
  • GC06P167675
  • GC06P167624
  • GC06P167704
  • GC06P165177

Summaries for UNC93A Gene

GeneCards Summary for UNC93A Gene

UNC93A (Unc-93 Homolog A (C. Elegans)) is a Protein Coding gene. An important paralog of this gene is UNC93B1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC93A Gene

Genomics for UNC93A Gene

Regulatory Elements for UNC93A Gene

Enhancers for UNC93A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G167243 1.2 Ensembl ENCODE dbSUPER 26.3 -26.1 -26087 2.7 CTCF SOX13 NFXL1 CHD7 BRCA1 TEAD3 FOSL1 SCRT2 SOX5 ZNF263 UNC93A LOC102724220 GC06M167245
GH06G167265 1.5 Ensembl ENCODE dbSUPER 20.4 -3.7 -3672 4.3 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 GATA2 UNC93A LOC102724220 GC06P167267
GH06G167223 1.4 Ensembl ENCODE dbSUPER 19.2 -44.5 -44543 6.9 FOXA2 ATF1 ARID4B DMAP1 GATA2 FOS PAF1 SP5 MXD4 MIER2 UNC93A GPR31 ENSG00000280707 LOC100420305
GH06G167240 1.1 Ensembl ENCODE 17.9 -29.4 -29369 3.2 PKNOX1 ARNT ARID4B DMAP1 YBX1 THRB ZNF48 TCF12 SLC30A9 ZNF766 UNC93A LOC102724220 LOC102725048
GH06G167150 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -118.6 -118630 3.4 PKNOX1 SIN3A ELK1 CBX5 FOS KLF13 SP5 JUNB REST TBX21 GPR31 RNASET2 CCR6 LOC105378120 FGFR1OP ENSG00000249141 UNC93A RPS6KA2 RPS6KA2-AS1 AFDN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UNC93A on UCSC Golden Path with GeneCards custom track

Genomic Location for UNC93A Gene

Chromosome:
6
Start:
167,271,169 bp from pter
End:
167,316,029 bp from pter
Size:
44,861 bases
Orientation:
Plus strand

Genomic View for UNC93A Gene

Genes around UNC93A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC93A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC93A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC93A Gene

Proteins for UNC93A Gene

  • Protein details for UNC93A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WB7-UN93A_HUMAN
    Recommended name:
    Protein unc-93 homolog A
    Protein Accession:
    Q86WB7
    Secondary Accessions:
    • B3KRP5
    • Q4QQJ4
    • Q5JZD6

    Protein attributes for UNC93A Gene

    Size:
    457 amino acids
    Molecular mass:
    50270 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function.
    SequenceCaution:
    • Sequence=CAI42706.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UNC93A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC93A Gene

Post-translational modifications for UNC93A Gene

No data available for DME Specific Peptides for UNC93A Gene

Domains & Families for UNC93A Gene

Protein Domains for UNC93A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UNC93A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WB7

UniProtKB/Swiss-Prot:

UN93A_HUMAN :
  • Belongs to the unc-93 family.
Family:
  • Belongs to the unc-93 family.
genes like me logo Genes that share domains with UNC93A: view

No data available for Gene Families for UNC93A Gene

Function for UNC93A Gene

Gene Ontology (GO) - Molecular Function for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with UNC93A: view
genes like me logo Genes that share phenotypes with UNC93A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC93A Gene

Localization for UNC93A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC93A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC93A gene
Compartment Confidence
plasma membrane 5
endosome 1

Gene Ontology (GO) - Cellular Components for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA 12381271
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 12381271
genes like me logo Genes that share ontologies with UNC93A: view

Pathways & Interactions for UNC93A Gene

SuperPathways for UNC93A Gene

No Data Available

Interacting Proteins for UNC93A Gene

Gene Ontology (GO) - Biological Process for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with UNC93A: view

No data available for Pathways by source and SIGNOR curated interactions for UNC93A Gene

Drugs & Compounds for UNC93A Gene

No Compound Related Data Available

Transcripts for UNC93A Gene

Unigene Clusters for UNC93A Gene

Unc-93 homolog A (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC93A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3:

Relevant External Links for UNC93A Gene

GeneLoc Exon Structure for
UNC93A
ECgene alternative splicing isoforms for
UNC93A

Expression for UNC93A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNC93A Gene

mRNA differential expression in normal tissues according to GTEx for UNC93A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x20.8), Skin - Not Sun Exposed (Suprapubic) (x14.4), and Liver (x9.6).

Protein differential expression in normal tissues from HIPED for UNC93A Gene

This gene is overexpressed in Fetal Liver (48.6) and Urine (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UNC93A Gene



Protein tissue co-expression partners for UNC93A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNC93A Gene:

UNC93A

SOURCE GeneReport for Unigene cluster for UNC93A Gene:

Hs.567508

mRNA Expression by UniProt/SwissProt for UNC93A Gene:

Q86WB7-UN93A_HUMAN
Tissue specificity: Expressed in testis, small intestine, spleen, prostate and ovary.

Evidence on tissue expression from TISSUES for UNC93A Gene

  • Liver(4.1)
  • Spleen(4)
genes like me logo Genes that share expression patterns with UNC93A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC93A Gene

Orthologs for UNC93A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UNC93A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC93A 34 35
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia UNC93A 34 35
  • 82.09 (n)
cow
(Bos Taurus)
Mammalia UNC93A 34 35
  • 78.34 (n)
mouse
(Mus musculus)
Mammalia Gm9992 34 35
  • 76.24 (n)
Unc93a 16 35
  • 72 (a)
Gm8597 35
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Unc93a 34
  • 75.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UNC93A 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves UNC93A 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487981 34
  • 61.1 (n)
Str.13374 34
zebrafish
(Danio rerio)
Actinopterygii unc93a 34 35
  • 62.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4928 34 35
  • 52.74 (n)
CG2121 35
  • 26 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000834 34
  • 52.23 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-93 34 35
  • 45.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09470 34
  • 44.47 (n)
rice
(Oryza sativa)
Liliopsida Os12g0566900 34
  • 45.12 (n)
Species where no ortholog for UNC93A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC93A Gene

ENSEMBL:
Gene Tree for UNC93A (if available)
TreeFam:
Gene Tree for UNC93A (if available)

Paralogs for UNC93A Gene

Paralogs for UNC93A Gene

(1) SIMAP similar genes for UNC93A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for UNC93A Gene

genes like me logo Genes that share paralogs with UNC93A: view

Variants for UNC93A Gene

Sequence variations from dbSNP and Humsavar for UNC93A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000022843 -- 167,280,920(+) TATCT(C/G)TATCA intron-variant
rs1000035796 -- 167,287,338(+) TCTGC(C/G/T)GCCCG intron-variant
rs1000078011 -- 167,276,354(+) CCTCT(C/G)GATGA intron-variant
rs1000151414 -- 167,267,952(+) CCGCC(C/T)CCTGC upstream-variant-2KB
rs1000181623 -- 167,280,519(+) TGTGC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC93A Gene

Variant ID Type Subtype PubMed ID
dgv1034e201 CNV deletion 23290073
dgv11056n54 CNV gain 21841781
dgv1240e214 CNV gain 21293372
dgv6194n100 CNV gain 25217958
dgv6196n100 CNV gain 25217958
dgv6197n100 CNV loss 25217958
dgv6198n100 CNV gain 25217958
esv24545 CNV gain+loss 19812545
esv2733230 CNV deletion 23290073
esv2733231 CNV deletion 23290073
esv2759492 CNV gain 17122850
esv2761058 CNV gain 21179565
esv3282385 CNV deletion 24192839
esv34252 CNV gain 17911159
esv3435434 CNV duplication 20981092
esv3576253 CNV gain 25503493
esv3611649 CNV gain 21293372
esv3611654 CNV loss 21293372
esv3611655 CNV gain 21293372
esv3611656 CNV loss 21293372
esv3611657 CNV loss 21293372
esv3611658 CNV gain 21293372
nsv1024654 CNV loss 25217958
nsv464141 CNV gain 19166990
nsv464145 CNV loss 19166990
nsv470873 CNV gain 18288195
nsv509170 CNV insertion 20534489
nsv517210 CNV gain+loss 19592680
nsv605338 CNV gain 21841781
nsv605343 CNV loss 21841781
nsv605344 CNV loss 21841781
nsv605345 CNV gain 21841781
nsv7389 OTHER inversion 18451855
nsv970192 CNV duplication 23825009

Variation tolerance for UNC93A Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.52; 94.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC93A Gene

Human Gene Mutation Database (HGMD)
UNC93A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC93A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC93A Gene

Disorders for UNC93A Gene

Relevant External Links for UNC93A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC93A

No disorders were found for UNC93A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC93A Gene

Publications for UNC93A Gene

  1. The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer. (PMID: 12381271) Liu Y. … Ganesan T.S. (BMC Genet. 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for UNC93A Gene

Sources for UNC93A Gene

Content
Loading form....