UNC93A Gene
protein-coding GIFtS: 47
GCID: GC06P167704
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unc-93 homolog A (C. elegans)(Previous name: unc93 (C.elegans) homolog A )
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Aliases
for UNC93A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Unc-93 Homolog A (C. Elegans)1 2 | | DJ366N23.1 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) LIKE)2 | | DJ366N23.11 | | DJ366N23.2 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) C-Terminal LIKE)2 | | DJ366N23.21 | | Protein Unc-93 Homolog A2 | | Unc-93A2 3 | | Unc93 Homolog A2 | | Unc93 (C.Elegans) Homolog A1 | | HmUnc-93A3 |
Export aliases for UNC93A gene to outside databasesPrevious GC identifers: GC06P167058 GC06P167578 GC06P167614 GC06P167675 GC06P167624 GC06P165177 |
Summaries
for UNC93A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for UNC93A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for UNC93A
Other transcription factors
Search SABiosciences Chromatin IP Primers for UNC93A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC93A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27UNC93A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P167704: view genomic region
(about GC identifiers)
Start:
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167,684,657 bp from pter |
End:
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167,729,507 bp from pter |
Size:
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44,851 bases |
Orientation:
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plus strand |
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Proteins
for UNC93A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UN93A_HUMAN, Q86WB7 (See
protein sequence)Recommended Name: Protein unc-93 homolog A Size: 457 amino acids; 50270 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, noevidence have been found for a tumor suppressor function
Sequence caution: Sequence=CAI42706.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KRP5 Q4QQJ4 Q5JZD6Alternative splicing: 2 isoforms: Q86WB7-1 Q86WB7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UNC93A: NX_Q86WB7
UNC93A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001137419.1 NP_061847.2
ENSEMBL proteins: ENSP00000421484 ENSP00000230256 ENSP00000355794
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
UNC93A for ontologies About GeneDecksing
UNC93A Antibody Products:
Assay Products for UNC93A: |
Protein
Domains /
Families
for UNC93A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UNC93A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86WB7ProtoNet protein and cluster: Q86WB7 UniProtKB/Swiss-Prot: UN93A_HUMAN, Q86WB7Similarity: Belongs to the unc-93 family |
Function
for UNC93A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC93A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC93A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): UNC93A (NM_001143947) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UNC93A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC93A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC93A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
UNC93A for ontologies About GeneDecksing
|
Pathways & Interactions
for UNC93A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UNC93A
2 Interacting proteins for UNC93A (Q86WB73) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
UNC93A for ontologies About GeneDecksing
|
Drugs & Compounds
for UNC93A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UNC93A
Search CenterWatch for drugs/clinical trials and news about UNC93A / UN93A
|
Transcripts
for UNC93A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UNC93A gene (2 alternative transcripts): NM_001143947.1 NM_018974.3 Unigene Cluster for UNC93A: Unc-93 homolog A (C. elegans) Hs.567508 [show with all ESTs]Unigene Representative Sequence: NM_0189745 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000503433 ENST00000230256(uc003qvq.3 uc003qvr.3) ENST00000366830
ENST00000366829 ENST00000504706
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC93A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC93A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UNC93A (NM_001143947) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UNC93A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC93A |
Additional cDNA sequence: AJ422141.1 AJ508812.1 AK091987.1 BC098248.1 BC099718.1 BC105635.1 3 DOTS entries: DT.40284045 DT.97839430 DT.111672 24/39 AceView cDNA sequences (see all 39): H47279 AX747293 AK091987 R16618 AJ508812 AJ422141 NM_018974 AI831447 BM748114 BG215813 AA702150 BM745638 BM753122 BM746467 BM783623 BV184724 CB113328 BM784293 AI191713 R16560 BM783448 AI655386 T60341 W78931
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC93A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UNC93A
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Expression
for UNC93A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UNC93A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See UNC93A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UNC93A
SOURCE GeneReport for Unigene cluster: Hs.567508
UniProtKB/Swiss-Prot: UN93A_HUMAN, Q86WB7Tissue specificity: Expressed in testis, small intestine, spleen, prostate and ovary
SABiosciences Custom PCR Arrays for UNC93A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UNC93A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UNC93A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC93A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC93A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC93A |
Orthologs
for UNC93A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UNC93A gene from 8/19 species (see all 19) About this table
ENSEMBL Gene Tree for UNC93A (if available)
TreeFam Gene Tree for UNC93A (if available) |
Paralogs
for UNC93A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UNC93A gene
- ENSG000002330942 UNC93B12
1 SIMAP similar gene for UNC93A using alignment to 2 protein entries: UN93A_HUMAN (see all proteins):UNC93B1
UNC93A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UNC93A
PGOHUM00000243456
|
Genomic Variants
for UNC93A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UNC93A (167684657 - 167729507 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for UNC93A
6 CNVs: 64716 2666 8539 51845 3653 69662
1 Inversion: 37270
Human Gene Mutation Database (HGMD): UNC93A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNC93A |
|
Disorders
/ Diseases
for UNC93A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UNC93A for disorders About GeneDecksing
OMIM gene information: 607995
OMIM disorders: --
4  diseases for UNC93A: About MalaCardsepithelial ovarian cancer ovarian cancer prostatitis neuronitis
Export disorders for UNC93A gene to outside databases
|
Publications
for UNC93A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UNC93A gene integrated from 9 sources:
(articles sorted by number of sources associating them with UNC93A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer. (PubMed id 12381271)1, 2, 3, 9 Liu Y.... Ganesan T.S. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for UNC93A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UNC93A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UNC93A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UNC93A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UNC93A gene:
Search GeneIP for patents involving UNC93A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UNC93A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for UNC93A | | OriGene shRNA RFP for UNC93A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC93A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UNC93A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UNC93A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC93A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC93A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UNC93A | | OriGene Custom Protein Services for UNC93A | | | OriGene Custom Immunoassay Development | | |
| |
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| | | | Search Tocris compounds for UNC93A |
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 | | | UNC93A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC93A |
|  |  |  | | | | ThermoFisher Antibodies for UNC93A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC93A |
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