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Aliases for UNC79 Gene

Aliases for UNC79 Gene

  • Unc-79 Homolog (C. Elegans) 2 3
  • KIAA1409 2 3 4
  • Protein Unc-79 Homolog 3

External Ids for UNC79 Gene

Previous Symbols for UNC79 Gene

  • KIAA1409

Summaries for UNC79 Gene

GeneCards Summary for UNC79 Gene

UNC79 (Unc-79 Homolog (C. Elegans)) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

UniProtKB/Swiss-Prot for UNC79 Gene

  • Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC79 Gene

Genomics for UNC79 Gene

Genomic Location for UNC79 Gene

Start:
93,333,219 bp from pter
End:
93,707,876 bp from pter
Size:
374,658 bases
Orientation:
Plus strand

Genomic View for UNC79 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNC79 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC79 Gene

No data available for Regulatory Elements for UNC79 Gene

Proteins for UNC79 Gene

  • Protein details for UNC79 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2D8-UNC79_HUMAN
    Recommended name:
    Protein unc-79 homolog
    Protein Accession:
    Q9P2D8
    Secondary Accessions:
    • B5MDL6
    • Q6ZUT7

    Protein attributes for UNC79 Gene

    Size:
    2635 amino acids
    Molecular mass:
    295326 Da
    Quaternary structure:
    • Interacts with NALCN and UNC80.

    Alternative splice isoforms for UNC79 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC79 Gene

Proteomics data for UNC79 Gene at MOPED

Post-translational modifications for UNC79 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC79 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC79 Gene

Domains for UNC79 Gene

Protein Domains for UNC79 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

UNC79_HUMAN
Family:
  • Belongs to the unc-79 family.:
    • Q9P2D8
genes like me logo Genes that share domains with UNC79: view

No data available for Gene Families for UNC79 Gene

Function for UNC79 Gene

Molecular function for UNC79 Gene

UniProtKB/Swiss-Prot Function: Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.

Gene Ontology (GO) - Molecular Function for UNC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with UNC79: view

Phenotypes for UNC79 Gene

genes like me logo Genes that share phenotypes with UNC79: view

Animal Models for UNC79 Gene

MGI Knock Outs for UNC79:

miRNA for UNC79 Gene

miRTarBase miRNAs that target UNC79

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for UNC79 Gene

Localization for UNC79 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC79 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for UNC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC79: view

Pathways for UNC79 Gene

genes like me logo Genes that share pathways with UNC79: view

Pathways by source for UNC79 Gene

Interacting Proteins for UNC79 Gene

Gene Ontology (GO) - Biological Process for UNC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030534 adult behavior --
GO:0034220 ion transmembrane transport TAS --
GO:0035264 multicellular organism growth IEA --
GO:0048149 behavioral response to ethanol IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with UNC79: view

Transcripts for UNC79 Gene

Unigene Clusters for UNC79 Gene

Unc-79 homolog (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC79 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:
SP2: - - - - - - - - - - - - - - - - -
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45 ^ 46 ^ 47 ^ 48a ·
SP1: -
SP2: - - - - - - - - - - - - - - - - - - - - -
SP3:

ExUns: 48b · 48c
SP1:
SP2:
SP3:

Relevant External Links for UNC79 Gene

GeneLoc Exon Structure for
UNC79
ECgene alternative splicing isoforms for
UNC79

Expression for UNC79 Gene

mRNA expression in normal human tissues for UNC79 Gene

mRNA differential expression in normal tissues according to GTEx for UNC79 Gene

This gene is overexpressed in Pituitary (7.0), Brain - Cerebellum (6.6), Brain - Cerebellar Hemisphere (6.5), and Brain - Cortex (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UNC79 Gene

SOURCE GeneReport for Unigene cluster for UNC79 Gene Hs.126561

genes like me logo Genes that share expressions with UNC79: view

Orthologs for UNC79 Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC79 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC79 36
  • 99.65 (n)
  • 99.63 (a)
UNC79 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC79 36
  • 91.4 (n)
  • 96.09 (a)
UNC79 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC79 36
  • 91.63 (n)
  • 96.81 (a)
UNC79 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc79 36
  • 89 (n)
  • 95.41 (a)
Unc79 16
Unc79 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNC79 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC79 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc79 36
  • 88.87 (n)
  • 95.43 (a)
chicken
(Gallus gallus)
Aves UNC79 36
  • 79.28 (n)
  • 89.69 (a)
UNC79 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC79 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc79 36
  • 75.88 (n)
  • 86.72 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01080274.1 37
  • 58 (a)
OneToMany
UNC79 (1 of 2) 37
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta unc79 36
  • 49.92 (n)
  • 40.79 (a)
unc79 37
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-79 36
  • 47.03 (n)
  • 35.31 (a)
unc-79 37
  • 29 (a)
OneToOne
Species with no ortholog for UNC79:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC79 Gene

ENSEMBL:
Gene Tree for UNC79 (if available)
TreeFam:
Gene Tree for UNC79 (if available)

Paralogs for UNC79 Gene

No data available for Paralogs for UNC79 Gene

Variants for UNC79 Gene

Sequence variations from dbSNP and Humsavar for UNC79 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2214 -- 93,336,290(-) ACTTA(C/T)CACTG intron-variant
rs169522 -- 93,361,113(-) actca(A/G)actcc intron-variant
rs185844 -- 93,432,448(+) gttgt(C/T)gtggg intron-variant
rs205319 -- 93,378,663(+) CTATT(G/T)TAATT intron-variant
rs205320 -- 93,379,431(+) TTCTG(C/T)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC79 Gene

Variant ID Type Subtype PubMed ID
esv2749032 CNV Deletion 23290073
esv267993 CNV Insertion 20981092
esv274066 CNV Insertion 20981092
nsv1403 CNV Insertion 18451855
nsv442355 CNV CNV 18776908
esv2614792 CNV Insertion 19546169
esv274235 CNV Insertion 20981092
esv2662647 CNV Deletion 23128226
esv2443272 OTHER Inversion 19546169
esv2749033 CNV Deletion 23290073
esv1414204 CNV Deletion 17803354
nsv1404 CNV Insertion 18451855

Relevant External Links for UNC79 Gene

HapMap Linkage Disequilibrium report
UNC79
Human Gene Mutation Database (HGMD)
UNC79

Disorders for UNC79 Gene

No disorders were found for UNC79 Gene.

No data available for UniProtKB/Swiss-Prot for UNC79 Gene

Publications for UNC79 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Conserved role of unc-79 in ethanol responses in lightweight mutant mice. (PMID: 20714347) Speca D.J. … McIntire S.L. (PLoS Genet. 2010) 2 3
  4. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. (PMID: 21040849) Lu B. … Ren D. (Neuron 2010) 2 3
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3

Products for UNC79 Gene

Sources for UNC79 Gene

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