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Aliases for UNC79 Gene

Aliases for UNC79 Gene

  • Unc-79 Homolog (C. Elegans) 2 3 5
  • KIAA1409 2 3 4

External Ids for UNC79 Gene

Previous HGNC Symbols for UNC79 Gene

  • KIAA1409

Previous GeneCards Identifiers for UNC79 Gene

  • GC14P093800

Summaries for UNC79 Gene

GeneCards Summary for UNC79 Gene

UNC79 (Unc-79 Homolog (C. Elegans)) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for UNC79 Gene

  • Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC79 Gene

Genomics for UNC79 Gene

Genomic Location for UNC79 Gene

93,333,219 bp from pter
93,707,878 bp from pter
374,660 bases
Plus strand

Genomic View for UNC79 Gene

Genes around UNC79 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC79 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC79 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC79 Gene

No data available for Regulatory Elements for UNC79 Gene

Proteins for UNC79 Gene

  • Protein details for UNC79 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein unc-79 homolog
    Protein Accession:
    Secondary Accessions:
    • B5MDL6
    • Q6ZUT7

    Protein attributes for UNC79 Gene

    2635 amino acids
    Molecular mass:
    295326 Da
    Quaternary structure:
    • Interacts with NALCN and UNC80.

    Alternative splice isoforms for UNC79 Gene


neXtProt entry for UNC79 Gene

Proteomics data for UNC79 Gene at MOPED

Post-translational modifications for UNC79 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC79 Gene

No data available for DME Specific Peptides for UNC79 Gene

Domains & Families for UNC79 Gene

Protein Domains for UNC79 Gene


Suggested Antigen Peptide Sequences for UNC79 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the unc-79 family.
  • Belongs to the unc-79 family.
genes like me logo Genes that share domains with UNC79: view

No data available for Gene Families for UNC79 Gene

Function for UNC79 Gene

Molecular function for UNC79 Gene

UniProtKB/Swiss-Prot Function:
Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.
genes like me logo Genes that share phenotypes with UNC79: view

Animal Models for UNC79 Gene

MGI Knock Outs for UNC79:

Animal Model Products

miRNA for UNC79 Gene

miRTarBase miRNAs that target UNC79

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC79 Gene

Localization for UNC79 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC79 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for UNC79 Gene COMPARTMENTS Subcellular localization image for UNC79 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for UNC79 Gene

Pathways & Interactions for UNC79 Gene

genes like me logo Genes that share pathways with UNC79: view

Pathways by source for UNC79 Gene

Interacting Proteins for UNC79 Gene

Gene Ontology (GO) - Biological Process for UNC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport TAS --
GO:0048149 behavioral response to ethanol IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with UNC79: view

No data available for SIGNOR curated interactions for UNC79 Gene

Drugs & Compounds for UNC79 Gene

No Compound Related Data Available

Transcripts for UNC79 Gene

Unigene Clusters for UNC79 Gene

Unc-79 homolog (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC79 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP2: - - - - - - - - - - - - - - - - -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45 ^ 46 ^ 47 ^ 48a ·
SP1: -
SP2: - - - - - - - - - - - - - - - - - - - - -

ExUns: 48b · 48c

Relevant External Links for UNC79 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNC79 Gene

mRNA expression in normal human tissues for UNC79 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC79 Gene

This gene is overexpressed in Pituitary (x7.0), Brain - Cerebellum (x6.6), Brain - Cerebellar Hemisphere (x6.5), and Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for UNC79 Gene

This gene is overexpressed in Serum (32.3) and Cervix (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC79 Gene

SOURCE GeneReport for Unigene cluster for UNC79 Gene Hs.126561

genes like me logo Genes that share expression patterns with UNC79: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for UNC79 Gene

Orthologs for UNC79 Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC79 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UNC79 36
  • 92 (a)
UNC79 35
  • 99.65 (n)
  • 99.63 (a)
(Bos Taurus)
Mammalia UNC79 35
  • 91.4 (n)
  • 96.09 (a)
UNC79 36
  • 87 (a)
(Canis familiaris)
Mammalia UNC79 36
  • 89 (a)
UNC79 35
  • 91.63 (n)
  • 96.81 (a)
(Mus musculus)
Mammalia Unc79 16
Unc79 36
  • 89 (a)
Unc79 35
  • 89 (n)
  • 95.41 (a)
(Monodelphis domestica)
Mammalia UNC79 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia UNC79 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Unc79 35
  • 88.87 (n)
  • 95.43 (a)
(Gallus gallus)
Aves UNC79 35
  • 79.28 (n)
  • 89.69 (a)
UNC79 36
  • 82 (a)
(Anolis carolinensis)
Reptilia UNC79 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia unc79 35
  • 75.88 (n)
  • 86.72 (a)
(Danio rerio)
Actinopterygii CABZ01080274.1 36
  • 58 (a)
UNC79 (1 of 2) 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta unc79 35
  • 49.92 (n)
  • 40.79 (a)
unc79 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea unc-79 35
  • 47.03 (n)
  • 35.31 (a)
unc-79 36
  • 29 (a)
Species with no ortholog for UNC79:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC79 Gene

Gene Tree for UNC79 (if available)
Gene Tree for UNC79 (if available)

Paralogs for UNC79 Gene

No data available for Paralogs for UNC79 Gene

Variants for UNC79 Gene

Sequence variations from dbSNP and Humsavar for UNC79 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs28670114 - 93,622,023(+) GCCGG(C/T)AAAGC nc-transcript-variant, reference, missense
rs4905081 - 93,622,241(+) CCTCC(A/G)TCCCC nc-transcript-variant, reference, missense
rs2296687 - 93,655,382(-) GCAGC(C/T)TGGCA reference, missense
rs7359096 - 93,690,244(+) ATGCA(A/G)GCTCC reference, missense
rs1058593 -- 93,690,222(+) CCCTG(C/T)CTGCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UNC79 Gene

Variant ID Type Subtype PubMed ID
esv2749032 CNV Deletion 23290073
esv267993 CNV Insertion 20981092
esv274066 CNV Insertion 20981092
nsv1403 CNV Insertion 18451855
nsv442355 CNV CNV 18776908
esv2614792 CNV Insertion 19546169
esv274235 CNV Insertion 20981092
esv2662647 CNV Deletion 23128226
esv2443272 OTHER Inversion 19546169
esv2749033 CNV Deletion 23290073
esv1414204 CNV Deletion 17803354
nsv1404 CNV Insertion 18451855

Variation tolerance for UNC79 Gene

Residual Variation Intolerance Score: 0.584% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC79 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC79 Gene

Disorders for UNC79 Gene

Relevant External Links for UNC79

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UNC79 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC79 Gene

Publications for UNC79 Gene

  1. Conserved role of unc-79 in ethanol responses in lightweight mutant mice. (PMID: 20714347) Speca D.J. … McIntire S.L. (PLoS Genet. 2010) 2 3 67
  2. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. (PMID: 21040849) Lu B. … Ren D. (Neuron 2010) 2 3
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  4. A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. (PMID: 20158304) Lind P.A. … Madden P.A. (Twin Res Hum Genet 2010) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for UNC79 Gene

Sources for UNC79 Gene

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