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Aliases for UNC79 Gene

Aliases for UNC79 Gene

  • Unc-79 Homolog (C. Elegans) 2 3 5
  • KIAA1409 2 3 4
  • Protein Unc-79 Homolog 3

External Ids for UNC79 Gene

Previous HGNC Symbols for UNC79 Gene

  • KIAA1409

Previous GeneCards Identifiers for UNC79 Gene

  • GC14P093800

Summaries for UNC79 Gene

GeneCards Summary for UNC79 Gene

UNC79 (Unc-79 Homolog (C. Elegans)) is a Protein Coding gene. Diseases associated with UNC79 include Esotropia. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for UNC79 Gene

  • Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC79 Gene

Genomics for UNC79 Gene

Regulatory Elements for UNC79 Gene

Enhancers for UNC79 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around UNC79 on UCSC Golden Path with GeneCards custom track

Promoters for UNC79 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for UNC79 Gene

Chromosome:
14
Start:
93,333,219 bp from pter
End:
93,707,878 bp from pter
Size:
374,660 bases
Orientation:
Plus strand

Genomic View for UNC79 Gene

Genes around UNC79 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC79 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC79 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC79 Gene

Proteins for UNC79 Gene

  • Protein details for UNC79 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2D8-UNC79_HUMAN
    Recommended name:
    Protein unc-79 homolog
    Protein Accession:
    Q9P2D8
    Secondary Accessions:
    • B5MDL6
    • Q6ZUT7

    Protein attributes for UNC79 Gene

    Size:
    2635 amino acids
    Molecular mass:
    295326 Da
    Quaternary structure:
    • Interacts with NALCN and UNC80.

    Alternative splice isoforms for UNC79 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC79 Gene

Post-translational modifications for UNC79 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC79 Gene

No data available for DME Specific Peptides for UNC79 Gene

Domains & Families for UNC79 Gene

Protein Domains for UNC79 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UNC79 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2D8

UniProtKB/Swiss-Prot:

UNC79_HUMAN :
  • Belongs to the unc-79 family.
Family:
  • Belongs to the unc-79 family.
genes like me logo Genes that share domains with UNC79: view

No data available for Gene Families for UNC79 Gene

Function for UNC79 Gene

Molecular function for UNC79 Gene

UniProtKB/Swiss-Prot Function:
Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.
genes like me logo Genes that share phenotypes with UNC79: view

Animal Models for UNC79 Gene

MGI Knock Outs for UNC79:

Animal Model Products

CRISPR Products

miRNA for UNC79 Gene

miRTarBase miRNAs that target UNC79

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC79 Gene

Localization for UNC79 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC79 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC79 Gene COMPARTMENTS Subcellular localization image for UNC79 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for UNC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC79: view

Pathways & Interactions for UNC79 Gene

genes like me logo Genes that share pathways with UNC79: view

Pathways by source for UNC79 Gene

Gene Ontology (GO) - Biological Process for UNC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030534 adult behavior IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0035264 multicellular organism growth IEA --
GO:0048149 behavioral response to ethanol IEA --
genes like me logo Genes that share ontologies with UNC79: view

No data available for SIGNOR curated interactions for UNC79 Gene

Drugs & Compounds for UNC79 Gene

No Compound Related Data Available

Transcripts for UNC79 Gene

Unigene Clusters for UNC79 Gene

Unc-79 homolog (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC79 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:
SP2: - - - - - - - - - - - - - - - - -
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45 ^ 46 ^ 47 ^ 48a ·
SP1: -
SP2: - - - - - - - - - - - - - - - - - - - - -
SP3:

ExUns: 48b · 48c
SP1:
SP2:
SP3:

Relevant External Links for UNC79 Gene

GeneLoc Exon Structure for
UNC79
ECgene alternative splicing isoforms for
UNC79

Expression for UNC79 Gene

mRNA expression in normal human tissues for UNC79 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC79 Gene

This gene is overexpressed in Pituitary (x7.0), Brain - Cerebellum (x6.6), Brain - Cerebellar Hemisphere (x6.5), and Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for UNC79 Gene

This gene is overexpressed in Serum (32.3) and Cervix (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC79 Gene



NURSA nuclear receptor signaling pathways regulating expression of UNC79 Gene:

UNC79

SOURCE GeneReport for Unigene cluster for UNC79 Gene:

Hs.126561
genes like me logo Genes that share expression patterns with UNC79: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for UNC79 Gene

Orthologs for UNC79 Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC79 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UNC79 34
  • 91.4 (n)
  • 96.09 (a)
UNC79 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC79 34
  • 91.63 (n)
  • 96.81 (a)
UNC79 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc79 34
  • 89 (n)
  • 95.41 (a)
Unc79 16
Unc79 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UNC79 34
  • 99.65 (n)
  • 99.63 (a)
UNC79 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc79 34
  • 88.87 (n)
  • 95.43 (a)
oppossum
(Monodelphis domestica)
Mammalia UNC79 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC79 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC79 34
  • 79.28 (n)
  • 89.69 (a)
UNC79 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC79 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc79 34
  • 75.88 (n)
  • 86.72 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01080274.1 35
  • 58 (a)
OneToMany
UNC79 (1 of 2) 35
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta unc79 34
  • 49.92 (n)
  • 40.79 (a)
unc79 35
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-79 34
  • 47.03 (n)
  • 35.31 (a)
unc-79 35
  • 29 (a)
OneToOne
Species where no ortholog for UNC79 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC79 Gene

ENSEMBL:
Gene Tree for UNC79 (if available)
TreeFam:
Gene Tree for UNC79 (if available)

Paralogs for UNC79 Gene

No data available for Paralogs for UNC79 Gene

Variants for UNC79 Gene

Sequence variations from dbSNP and Humsavar for UNC79 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs28670114 - 93,622,023(+) GCCGG(C/T)AAAGC nc-transcript-variant, reference, missense
rs4905081 - 93,622,241(+) CCTCC(A/G)TCCCC nc-transcript-variant, reference, missense
rs2296687 - 93,655,382(-) GCAGC(C/T)TGGCA reference, missense
rs7359096 - 93,690,244(+) ATGCA(A/G)GCTCC reference, missense
rs1503958 -- 93,392,264(+) GACAG(C/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC79 Gene

Variant ID Type Subtype PubMed ID
esv1414204 CNV deletion 17803354
esv2443272 OTHER inversion 19546169
esv2614792 CNV insertion 19546169
esv2662647 CNV deletion 23128226
esv2749032 CNV deletion 23290073
esv2749033 CNV deletion 23290073
esv3309963 CNV mobile element insertion 20981092
esv3345634 CNV insertion 20981092
esv3384347 CNV insertion 20981092
esv3393610 CNV insertion 20981092
esv3551980 CNV deletion 23714750
esv3635361 CNV loss 21293372
esv3635362 CNV gain 21293372
nsv1079024 OTHER inversion 25765185
nsv1112650 CNV deletion 24896259
nsv1116041 CNV deletion 24896259
nsv1130683 CNV deletion 24896259
nsv1153316 CNV duplication 26484159
nsv1403 CNV insertion 18451855
nsv1404 CNV insertion 18451855
nsv442355 CNV loss 18776908
nsv477891 CNV novel sequence insertion 20440878

Variation tolerance for UNC79 Gene

Residual Variation Intolerance Score: 0.584% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC79 Gene

Human Gene Mutation Database (HGMD)
UNC79
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC79

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC79 Gene

Disorders for UNC79 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UNC79 Gene - From: DISEASES

Disorder Aliases PubMed IDs
esotropia
  • convergence in manifest squint
- elite association - COSMIC cancer census association via MalaCards
Search UNC79 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UNC79

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC79
genes like me logo Genes that share disorders with UNC79: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UNC79 Gene

Publications for UNC79 Gene

  1. Conserved role of unc-79 in ethanol responses in lightweight mutant mice. (PMID: 20714347) Speca D.J. … McIntire S.L. (PLoS Genet. 2010) 2 3 65
  2. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. (PMID: 21040849) Lu B. … Ren D. (Neuron 2010) 2 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 65
  5. Mutations in UNC80, encoding part of the UNC79-UNC80-NALCN channel complex, cause autosomal-recessive severe infantile encephalopathy. (PMID: 26708753) Shamseldin H.E. … Alkuraya F.S. (Am. J. Hum. Genet. 2016) 3 65

Products for UNC79 Gene

Sources for UNC79 Gene

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