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Aliases for UNC5D Gene

Aliases for UNC5D Gene

  • Unc-5 Netrin Receptor D 2 3 5
  • Protein Unc-5 Homolog 4 3 4
  • Protein Unc-5 Homolog D 3 4
  • Unc5h4 3 4
  • Unc-5 Homolog D (C. Elegans) 2
  • Netrin Receptor Unc5h4 3
  • Netrin Receptor UNC5D 3
  • Unc-5 Homolog 4 3
  • Unc-5 Homolog D 3
  • PRO34692 3
  • KIAA1777 4

External Ids for UNC5D Gene

Previous GeneCards Identifiers for UNC5D Gene

  • GC08P035858
  • GC08P035459
  • GC08P035521
  • GC08P033626

Summaries for UNC5D Gene

GeneCards Summary for UNC5D Gene

UNC5D (Unc-5 Netrin Receptor D) is a Protein Coding gene. Among its related pathways are Netrin-1 signaling and Guidance Cues and Growth Cone Motility. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot for UNC5D Gene

  • Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5D Gene

Genomics for UNC5D Gene

Regulatory Elements for UNC5D Gene

Enhancers for UNC5D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around UNC5D on UCSC Golden Path with GeneCards custom track

Promoters for UNC5D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for UNC5D Gene

Chromosome:
8
Start:
35,235,457 bp from pter
End:
35,796,550 bp from pter
Size:
561,094 bases
Orientation:
Plus strand

Genomic View for UNC5D Gene

Genes around UNC5D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5D Gene

Proteins for UNC5D Gene

  • Protein details for UNC5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXZ4-UNC5D_HUMAN
    Recommended name:
    Netrin receptor UNC5D
    Protein Accession:
    Q6UXZ4
    Secondary Accessions:
    • Q8WYP7

    Protein attributes for UNC5D Gene

    Size:
    953 amino acids
    Molecular mass:
    105880 Da
    Quaternary structure:
    • Interacts (via extracellular domain) with FLRT2 (via extracellular domain); the interaction is direct (By similarity). Interacts (via extracellular domain) with FLRT3 (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (PubMed:26235030).

    Alternative splice isoforms for UNC5D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5D Gene

Post-translational modifications for UNC5D Gene

  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Glycosylation at Asn 117, Asn 228, Asn 353, and Asn 376
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC5D Gene

No data available for DME Specific Peptides for UNC5D Gene

Domains & Families for UNC5D Gene

Gene Families for UNC5D Gene

Suggested Antigen Peptide Sequences for UNC5D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXZ4

UniProtKB/Swiss-Prot:

UNC5D_HUMAN :
  • Contains 1 death domain.
  • Belongs to the unc-5 family.
Domain:
  • Contains 1 death domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 2 TSP type-1 domains.
  • Contains 1 ZU5 domain.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5D: view

Function for UNC5D Gene

Molecular function for UNC5D Gene

UniProtKB/Swiss-Prot Function:
Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53 in response to DNA damage.
genes like me logo Genes that share phenotypes with UNC5D: view

Animal Models for UNC5D Gene

MGI Knock Outs for UNC5D:

Animal Model Products

  • Taconic Biosciences Mouse Models for UNC5D

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC5D Gene

Localization for UNC5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5D Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5D Gene COMPARTMENTS Subcellular localization image for UNC5D gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UNC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC5D: view

Pathways & Interactions for UNC5D Gene

genes like me logo Genes that share pathways with UNC5D: view

Pathways by source for UNC5D Gene

1 KEGG pathway for UNC5D Gene
2 Qiagen pathways for UNC5D Gene

Interacting Proteins for UNC5D Gene

Gene Ontology (GO) - Biological Process for UNC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007411 axon guidance IEA --
GO:0021859 pyramidal neuron differentiation IEA --
GO:0098609 cell-cell adhesion IDA 26235030
genes like me logo Genes that share ontologies with UNC5D: view

No data available for SIGNOR curated interactions for UNC5D Gene

Drugs & Compounds for UNC5D Gene

No Compound Related Data Available

Transcripts for UNC5D Gene

Unigene Clusters for UNC5D Gene

Unc-5 homolog D (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP3: - -

Relevant External Links for UNC5D Gene

GeneLoc Exon Structure for
UNC5D
ECgene alternative splicing isoforms for
UNC5D

Expression for UNC5D Gene

mRNA expression in normal human tissues for UNC5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5D Gene

This gene is overexpressed in Brain - Hypothalamus (x6.8), Brain - Frontal Cortex (BA9) (x6.1), Brain - Cortex (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.4), and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for UNC5D Gene

This gene is overexpressed in Liver (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5D Gene



Protein tissue co-expression partners for UNC5D Gene

NURSA nuclear receptor signaling pathways regulating expression of UNC5D Gene:

UNC5D

SOURCE GeneReport for Unigene cluster for UNC5D Gene:

Hs.238889
genes like me logo Genes that share expression patterns with UNC5D: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UNC5D Gene

Orthologs for UNC5D Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UNC5D 34
  • 91.33 (n)
  • 97.55 (a)
UNC5D 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC5D 34
  • 92.74 (n)
  • 98.17 (a)
UNC5D 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc5d 34
  • 90.36 (n)
  • 97.12 (a)
Unc5d 16
Unc5d 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UNC5D 34
  • 99.51 (n)
  • 100 (a)
UNC5D 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc5d 34
  • 90.68 (n)
  • 97.33 (a)
oppossum
(Monodelphis domestica)
Mammalia UNC5D 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC5D 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC5D 34
  • 79.54 (n)
  • 88.07 (a)
UNC5D 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC5D 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5d 34
  • 75.86 (n)
  • 81.46 (a)
zebrafish
(Danio rerio)
Actinopterygii unc5da 34
  • 67.8 (n)
  • 69 (a)
UNC5D (3 of 3) 35
  • 73 (a)
OneToMany
unc5da 35
  • 66 (a)
OneToMany
unc5db 35
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-5 36
  • 26 (a)
Species where no ortholog for UNC5D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC5D Gene

ENSEMBL:
Gene Tree for UNC5D (if available)
TreeFam:
Gene Tree for UNC5D (if available)

Paralogs for UNC5D Gene

Paralogs for UNC5D Gene

(3) SIMAP similar genes for UNC5D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with UNC5D: view

Variants for UNC5D Gene

Sequence variations from dbSNP and Humsavar for UNC5D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs35487923 - 35,759,339(-) GATGC(C/T)TTTCA reference, missense
rs953345 -- 35,485,033(+) CAGAG(A/G)TGTAT intron-variant
rs953346 -- 35,484,933(+) AGGAT(G/T)TCTAA intron-variant
rs953347 -- 35,484,941(+) TAACT(C/G)CAGTT intron-variant
rs956755 -- 35,658,135(-) AATAA(A/G)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5D Gene

Variant ID Type Subtype PubMed ID
dgv12089n54 CNV loss 21841781
dgv1279e199 CNV deletion 23128226
esv1962769 CNV deletion 18987734
esv24068 CNV loss 19812545
esv2483846 CNV deletion 19546169
esv2530621 CNV deletion 19546169
esv2532641 CNV deletion 19546169
esv2632134 CNV insertion 19546169
esv2657552 CNV deletion 23128226
esv2663137 CNV deletion 23128226
esv2675242 CNV deletion 23128226
esv2736875 CNV deletion 23290073
esv275263 CNV loss 21479260
esv28759 CNV loss 19812545
esv3329938 CNV duplication 20981092
esv3432912 CNV insertion 20981092
esv3543350 CNV deletion 23714750
esv3543353 CNV deletion 23714750
esv3616881 CNV loss 21293372
esv3616884 CNV loss 21293372
esv3616886 CNV loss 21293372
esv3616887 CNV loss 21293372
esv3616888 CNV loss 21293372
esv3616890 CNV loss 21293372
nsv1075130 CNV deletion 25765185
nsv1109966 CNV deletion 24896259
nsv1109967 CNV deletion 24896259
nsv1115086 CNV deletion 24896259
nsv1128411 CNV deletion 24896259
nsv1148503 CNV duplication 26484159
nsv396482 CNV deletion 16902084
nsv520421 CNV gain 19592680
nsv6150 CNV insertion 18451855
nsv6151 CNV deletion 18451855
nsv6152 CNV insertion 18451855
nsv820115 CNV gain 19587683
nsv831284 CNV gain 17160897
nsv831285 CNV loss 17160897
nsv971297 CNV duplication 23825009

Variation tolerance for UNC5D Gene

Residual Variation Intolerance Score: 6.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC5D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC5D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5D Gene

Disorders for UNC5D Gene

Relevant External Links for UNC5D

Genetic Association Database (GAD)
UNC5D
Human Genome Epidemiology (HuGE) Navigator
UNC5D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC5D

No disorders were found for UNC5D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5D Gene

Publications for UNC5D Gene

  1. Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion. (PMID: 26235030) Lu Y.C. … Arac D. (Structure 2015) 3 4 65
  2. Overexpression of the dependence receptor UNC5H4 inhibits cell migration and invasion, and triggers apoptosis in neuroblastoma cell. (PMID: 24519068) Wang H. … Hao L. (Tumour Biol. 2014) 3 4 65
  3. Unc5D regulates p53-dependent apoptosis in neuroblastoma cells. (PMID: 24691657) Wang H. … Hao L. (Mol Med Rep 2014) 3 4 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. (PMID: 18402767) Wang H. … Nakagawara A. (Biochem. Biophys. Res. Commun. 2008) 2 3 65

Products for UNC5D Gene

Sources for UNC5D Gene

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