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UNC5D Gene

protein-coding   GIFtS: 55
GCID: GC08P035183

Unc-5 Homolog D (C. Elegans)

  Search for UNC5D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-5 Homolog D (C. Elegans)1 2     Netrin Receptor UNC5D2
Protein Unc-5 Homolog 42 3     Netrin Receptor Unc5h42
Protein Unc-5 Homolog D2 3     Unc-5 Homolog 42
PRO346922     KIAA17773
Unc5h42     UNC5H43

External Ids:    HGNC: 186341   Entrez Gene: 1379702   Ensembl: ENSG000001566877   UniProtKB: Q6UXZ43   

Export aliases for UNC5D gene to outside databases

Previous GC identifers: GC08P035858 GC08P035459 GC08P035521 GC08P033626


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UNC5D Gene:
UNC5D (unc-5 homolog D (C. elegans)) is a protein-coding gene. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4
Function: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth
cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its
association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for
apoptosis induction when not associated with netrin ligand (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UNC5D gene promoter:
         TBP   Sox5   MEF-2   Nkx2-5   Arnt   C/EBPalpha   HEN1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): UNC5D promoter sequence
   Search Chromatin IP Primers for UNC5D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNC5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

UNC5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5D gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P035183:  view genomic region     (about GC identifiers)

Start:
35,092,975 bp from pter      End:
35,654,068 bp from pter
Size:
561,094 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4 (See protein sequence)
Recommended Name: Netrin receptor UNC5D precursor  
Size: 953 amino acids; 105880 Da
Subunit: Interacts with the cytoplasmic part of DCC (By similarity)
Secondary accessions: Q8WYP7
Alternative splicing: 2 isoforms:  Q6UXZ4-1   Q6UXZ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNC5D: NX_Q6UXZ4

Explore proteomics data for UNC5D at MOPED

Post-translational modifications: 

  • Phosphorylated on cytoplasmic tyrosine residues (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is
    associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)1
  • Glycosylation2 at Asn117, Asn228, Asn353, Asn376
  • Modification sites at PhosphoSitePlus

  • See UNC5D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_543148.2  
    ENSEMBL proteins: 
     ENSP00000385143   ENSP00000392739   ENSP00000287272   ENSP00000412652   ENSP00000394303  
     ENSP00000397211  
    Reactome Protein details: Q6UXZ4

    UNC5D Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals UNC5D Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UNC5D

     
    Search eBioscience for Proteins for UNC5D 

    UNC5D Antibody Products:

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    Abcam antibodies for UNC5D
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    LSBio Antibodies in human, mouse, rat for UNC5D

    UNC5D Assay Products:

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    Cloud-Clone Corp. ELISAs for UNC5D
    Cloud-Clone Corp. CLIAs for UNC5D
    Search eBioscience for ELISAs for UNC5D 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set
     IPR000906 ZU5

    Graphical View of Domain Structure for InterPro Entry Q6UXZ4

    ProtoNet protein and cluster: Q6UXZ4

    4 Blocks protein domains:
    IPB000488 Death domain
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 2 TSP type-1 domains
    Similarity: Contains 1 ZU5 domain


    Find genes that share domains with UNC5D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC5D_HUMAN, Q6UXZ4
    Function: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth
    cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its
    association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for
    apoptosis induction when not associated with netrin ligand (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with UNC5D           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Unc5d):
     behavior/neurological  cellular  nervous system 

    Find genes that share phenotypes with UNC5D           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UNC5D
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UNC5D
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    miRNA
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    miRTarBase miRNAs that target UNC5D:
    hsa-mir-124-3p (MIRT022228)

    Block miRNA regulation of human, mouse, rat UNC5D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UNC5D (see all 81):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-30d hsa-miR-10b* hsa-miR-1304 hsa-miR-30a hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: UNC5D (NM_080872)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5D

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UNC5D_HUMAN, Q6UXZ4: Membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UNC5D           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UNC5D About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Netrin-1 signaling
    Netrin-1 signaling
    Netrin mediated repulsion signals0.00
    3Netrin Signaling
    Netrin Signaling
    4Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility
    5Axon guidance
    Axon guidance


    Find genes that share SuperPaths with UNC5D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UNC5D
        Guidance Cues and Growth Cone Motility
    Netrin Signaling

    1 Reactome Pathway for UNC5D
        Netrin mediated repulsion signals


    1 Kegg Pathway  (Kegg details for UNC5D):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNC5D
    Interactions:

        GeneGlobe Interaction Network for UNC5D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for UNC5D (ENSP000003851434) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCCENSP000003891404STRING: ENSP00000389140
    NTN1ENSP000001732294STRING: ENSP00000173229
    UNC5AENSP000003327374STRING: ENSP00000332737
    UNC5BENSP000003343294STRING: ENSP00000334329
    UNC5CENSP000004060224STRING: ENSP00000406022
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance TAS--
    GO:0021859pyramidal neuron differentiation IEA--

    Find genes that share ontologies with UNC5D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNC5D



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UNC5D gene: 
    NM_080872.2  

    Unigene Cluster for UNC5D:

    Unc-5 homolog D (C. elegans)
    Hs.238889  [show with all ESTs]
    Unigene Representative Sequence: NM_080872
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404895 ENST00000420357 ENST00000287272(uc003xju.2) ENST00000416672
    ENST00000453357(uc003xjr.2 uc003xjs.2) ENST00000474634(uc003xjt.1)
    ENST00000449677
    miRNA
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    Block miRNA regulation of human, mouse, rat UNC5D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UNC5D (see all 81):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-30d hsa-miR-10b* hsa-miR-1304 hsa-miR-30a hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: UNC5D (NM_080872)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5D
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UNC5D
      QuantiTect SYBR Green Assays in human, mouse, rat UNC5D
      QuantiFast Probe-based Assays in human, mouse, rat UNC5D

    Additional mRNA sequence: 

    AB055056.1 AB073394.1 AF466364.1 AK092313.1 AK122610.1 AK122615.1 AY358147.1 

    7 DOTS entries:

    DT.211429  DT.97824070  DT.101960734  DT.101973919  DT.101983794  DT.100642490  DT.101983796 

    Selected AceView cDNA sequences (see all 49):

    CD672650 BM726542 BM702977 CK904280 AA872790 AI802048 AK122615 AB055056 
    D38687 BM021445 BM021175 AA878235 NM_080872 AY358147 AI912801 AK122610 
    AK092313 BE673998 AI004193 BU729454 AI972558 AU252699 BE670455 AL120369 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5D    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                                              -           -                                                   
    SP2:                                                                          -                                                   
    SP3:                                                  -           -                                                               


    ECgene alternative splicing isoforms for UNC5D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UNC5D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UNC5D Expression
    About this image


    UNC5D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
    UNC5D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNC5D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.238889
        Custom PCR Arrays for UNC5D
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UNC5D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UNC5D
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    QuantiFast Probe-based Assays in human, mouse, rat UNC5D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UNC5D gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc5d1 , 5 unc-5 homolog D (C. elegans)1, 5 90.36(n)1
    97.12(a)1
      8 (16.47 cM)5
    2108011  NM_153135.31  NP_694775.11 
     286467175 
    chicken
    (Gallus gallus)
    Aves UNC5D1 unc-5 homolog D (C. elegans) 79.54(n)
    88.07(a)
      426920  XM_004947581.1  XP_004947638.1 
    lizard
    (Anolis carolinensis)
    Reptilia UNC5D6
    unc-5 homolog D (C. elegans)
    83(a)
    1 ↔ 1
    GL343238.1(1782641-2150819)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia unc5d1 unc-5 homolog D (C. elegans) 75.86(n)
    81.46(a)
      100490873  XM_002932956.2  XP_002933002.2 
    zebrafish
    (Danio rerio)
    Actinopterygii unc5da1 unc-5 homolog Da (C. elegans) 67.8(n)
    69(a)
      566274  XM_003200856.2  XP_003200904.2 


    ENSEMBL Gene Tree for UNC5D (if available)
    TreeFam Gene Tree for UNC5D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UNC5D gene
    UNC5B2  BAI12  UNC5C2  UNC5A2  UNC5CL2  CFP2  BAI32  BAI22  
    3 SIMAP similar genes for UNC5D using alignment to 5 protein entries:     UNC5D_HUMAN (see all proteins):
    UNC5B    UNC5C    UNC5A

    Find genes that share paralogs with UNC5D           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UNC5D (see all 10128)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383670961,2
    C--33720401(+) GGTTG-/ATAT  
      ATATAT
    ATATA
    1 -- int10--------
    rs1452368941,2
    --35090984(+) ATTTGA/GTAGAT 1 -- us2k10--------
    rs1876284151,2
    --35091132(+) TCTTGA/CCTAGG 1 -- us2k10--------
    rs1448673061,2
    --35091174(+) CGGAGC/GAAACA 1 -- us2k10--------
    rs774691571,2
    --35091205(+) TTCACG/TTGTCT 1 -- us2k10--------
    rs1431677041,2
    --35091349(+) ACTGTA/TTATTC 1 -- us2k10--------
    rs1482531561,2
    --35091536(+) GGACTC/GGATCC 1 -- us2k10--------
    rs105951551,2
    C--35091736(+) CACTT-/A/AA  
            
    AAAAA
    1 -- us2k1 trp32NA 4
    rs1413135371,2
    C--35091837(+) ATGAGA/GCCACA 1 -- us2k10--------
    rs1915046081,2
    C--35091941(+) CATCAA/GACAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC5D (35092975 - 35342975 bp, first 250kb of UNC5D)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UNC5D (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736875CNV Deletion23290073
    esv2663137CNV Deletion23128226
    esv2532641CNV Deletion19546169
    esv2483846CNV Deletion19546169
    esv2657552CNV Deletion23128226
    esv2530621CNV Deletion19546169
    dgv1279e199CNV Deletion23128226
    esv1962769CNV Deletion18987734
    esv2675242CNV Deletion23128226
    esv2632134CNV Insertion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC5D
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC5D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with UNC5D           About GenesLikeMe

    Genetic Association Database (GAD): UNC5D
    Human Genome Epidemiology (HuGE) Navigator: UNC5D (1 document)

    Export disorders for UNC5D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UNC5D gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with UNC5D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. (PubMed id 18402767)1, 3 Wang H....Nakagawara A. (Biochem. Biophys. Res. Commun. 2008)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression. (PubMed id 23778138)1 Zhu Y....Nakagawara A. (J. Clin. Invest. 2013)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. The tumor-suppressive function of UNC5D and its repressed expression in renal cell carcinoma. (PubMed id 23589179)1 Lu D....Zhang J. (Clin. Cancer Res. 2013)
    7. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    9. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    10. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (Physiol. Genomics 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 137970 HGNC: 18634 AceView: UNC5D Ensembl:ENSG00000156687 euGenes: HUgn137970
    ECgene: UNC5D Kegg: 137970 H-InvDB: UNC5D

    (According to HUGE)
    About This Section

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    HUGE: KIAA1777

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UNC5D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UNC5D gene:
    Search GeneIP for patents involving UNC5D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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