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Aliases for UNC5D Gene

Aliases for UNC5D Gene

  • Unc-5 Homolog D (C. Elegans) 2 3
  • Protein Unc-5 Homolog 4 3 4
  • Protein Unc-5 Homolog D 3 4
  • Unc5h4 3 4
  • Netrin Receptor Unc5h4 3
  • Netrin Receptor UNC5D 3
  • Unc-5 Homolog 4 3
  • PRO34692 3
  • KIAA1777 4

External Ids for UNC5D Gene

Summaries for UNC5D Gene

GeneCards Summary for UNC5D Gene

UNC5D (Unc-5 Homolog D (C. Elegans)) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. An important paralog of this gene is UNC5A.

UniProtKB/Swiss-Prot for UNC5D Gene

  • Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5D Gene

Genomics for UNC5D Gene

Genomic Location for UNC5D Gene

Start:
35,235,457 bp from pter
End:
35,796,550 bp from pter
Size:
561,094 bases
Orientation:
Plus strand

Genomic View for UNC5D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNC5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5D Gene

Regulatory Elements for UNC5D Gene

Proteins for UNC5D Gene

  • Protein details for UNC5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXZ4-UNC5D_HUMAN
    Recommended name:
    Netrin receptor UNC5D
    Protein Accession:
    Q6UXZ4
    Secondary Accessions:
    • Q8WYP7

    Protein attributes for UNC5D Gene

    Size:
    953 amino acids
    Molecular mass:
    105880 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DCC.

    Alternative splice isoforms for UNC5D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5D Gene

Proteomics data for UNC5D Gene at MOPED

Post-translational modifications for UNC5D Gene

  • Phosphorylated on cytoplasmic tyrosine residues.
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn117, Asn228, Asn353, and Asn376

Other Protein References for UNC5D Gene

No data available for DME Specific Peptides for UNC5D Gene

Domains for UNC5D Gene

Gene Families for UNC5D Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

UniProtKB/Swiss-Prot:

UNC5D_HUMAN
Domain:
  • Contains 1 death domain.:
    • Q6UXZ4
  • Contains 1 Ig-like (immunoglobulin-like) domain.:
    • Q6UXZ4
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q6UXZ4
  • Contains 2 TSP type-1 domains.:
    • Q6UXZ4
  • Contains 1 ZU5 domain.:
    • Q6UXZ4
Family:
  • Belongs to the unc-5 family.:
    • Q6UXZ4
genes like me logo Genes that share domains with UNC5D: view

Function for UNC5D Gene

Molecular function for UNC5D Gene

UniProtKB/Swiss-Prot Function: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

Gene Ontology (GO) - Molecular Function for UNC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with UNC5D: view

Phenotypes for UNC5D Gene

genes like me logo Genes that share phenotypes with UNC5D: view

miRNA for UNC5D Gene

miRTarBase miRNAs that target UNC5D

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UNC5D Gene

Localization for UNC5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5D Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5D Gene COMPARTMENTS Subcellular localization image for UNC5D gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UNC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC5D: view

Pathways for UNC5D Gene

genes like me logo Genes that share pathways with UNC5D: view

Pathways by source for UNC5D Gene

1 KEGG pathway for UNC5D Gene

Interacting Proteins for UNC5D Gene

Gene Ontology (GO) - Biological Process for UNC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007411 axon guidance TAS --
GO:0021859 pyramidal neuron differentiation IEA --
GO:2001222 regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with UNC5D: view

Transcripts for UNC5D Gene

Unigene Clusters for UNC5D Gene

Unc-5 homolog D (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP3: - -

Relevant External Links for UNC5D Gene

GeneLoc Exon Structure for
UNC5D
ECgene alternative splicing isoforms for
UNC5D

Expression for UNC5D Gene

mRNA expression in normal human tissues for UNC5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5D Gene

This gene is overexpressed in Brain - Hypothalamus (6.8), Brain - Frontal Cortex (BA9) (6.1), Brain - Cortex (4.4), Brain - Anterior cingulate cortex (BA24) (4.4), and Pituitary (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UNC5D Gene

SOURCE GeneReport for Unigene cluster for UNC5D Gene Hs.238889

genes like me logo Genes that share expressions with UNC5D: view

Orthologs for UNC5D Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC5D 36
  • 99.51 (n)
  • 100 (a)
UNC5D 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC5D 36
  • 91.33 (n)
  • 97.55 (a)
UNC5D 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC5D 36
  • 92.74 (n)
  • 98.17 (a)
UNC5D 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc5d 36
  • 90.36 (n)
  • 97.12 (a)
Unc5d 16
Unc5d 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNC5D 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC5D 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc5d 36
  • 90.68 (n)
  • 97.33 (a)
chicken
(Gallus gallus)
Aves UNC5D 36
  • 79.54 (n)
  • 88.07 (a)
UNC5D 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC5D 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5d 36
  • 75.86 (n)
  • 81.46 (a)
zebrafish
(Danio rerio)
Actinopterygii UNC5D (3 of 3) 37
  • 73 (a)
OneToMany
unc5da 36
  • 67.8 (n)
  • 69 (a)
unc5da 37
  • 66 (a)
OneToMany
unc5db 37
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-5 38
  • 26 (a)
Species with no ortholog for UNC5D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC5D Gene

ENSEMBL:
Gene Tree for UNC5D (if available)
TreeFam:
Gene Tree for UNC5D (if available)

Paralogs for UNC5D Gene

Paralogs for UNC5D Gene

Selected SIMAP similar genes for UNC5D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with UNC5D: view

Variants for UNC5D Gene

Sequence variations from dbSNP and Humsavar for UNC5D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3744 -- 35,287,402(-) ttttc(A/T)ttttg intron-variant
rs723386 -- 35,618,024(-) ATTAA(A/G)GTTTA intron-variant
rs750553 -- 35,608,197(-) GCATA(C/T)ACATT intron-variant
rs750675 -- 35,607,197(+) TGGAA(C/T)GAGGG intron-variant
rs750676 -- 35,607,504(+) tgata(C/T)gattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5D Gene

Variant ID Type Subtype PubMed ID
nsv831284 CNV Gain 17160897
dgv1279e199 CNV Deletion 23128226
nsv520421 CNV Gain 19592680
nsv396482 CNV Loss 16902084
nsv6150 CNV Insertion 18451855
nsv890717 CNV Loss 21882294
esv2675242 CNV Deletion 23128226
esv28759 CNV Loss 19812545
esv2530621 CNV Deletion 19546169
esv2657552 CNV Deletion 23128226
esv2632134 CNV Insertion 19546169
esv275263 CNV Loss 21479260
esv24068 CNV Loss 19812545
nsv831285 CNV Loss 17160897
nsv6151 CNV Loss 18451855
nsv6152 CNV Insertion 18451855
esv2483846 CNV Deletion 19546169
esv2736875 CNV Deletion 23290073
esv1962769 CNV Deletion 18987734
esv2532641 CNV Deletion 19546169
esv2663137 CNV Deletion 23128226
nsv820115 CNV Gain 19587683

Relevant External Links for UNC5D Gene

HapMap Linkage Disequilibrium report
UNC5D

Disorders for UNC5D Gene

Relevant External Links for UNC5D

Genetic Association Database (GAD)
UNC5D
Human Genome Epidemiology (HuGE) Navigator
UNC5D
genes like me logo Genes that share disorders with UNC5D: view

No data available for UniProtKB/Swiss-Prot for UNC5D Gene

Publications for UNC5D Gene

  1. A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. (PMID: 18402767) Wang H. … Nakagawara A. (Biochem. Biophys. Res. Commun. 2008) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Identification of the genes that are expressed in the upper layers of the neocortex. (PMID: 15142956) Zhong Y. … Yamamoto N. (Cereb. Cortex 2004) 3

Products for UNC5D Gene

Sources for UNC5D Gene

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