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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC5D Gene

protein-coding   GIFtS: 54
GCID: GC08P035183

Unc-5 Homolog D (C. Elegans)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Unc-5 Homolog D (C. Elegans)1 2     Netrin Receptor UNC5D2
Protein Unc-5 Homolog 42 3     Netrin Receptor Unc5h42
Protein Unc-5 Homolog D2 3     Unc-5 Homolog 42
PRO346922     KIAA17773
Unc5h42     UNC5H43

External Ids:    HGNC: 186341   Entrez Gene: 1379702   Ensembl: ENSG000001566877   UniProtKB: Q6UXZ43   

Export aliases for UNC5D gene to outside databases

Previous GC identifers: GC08P035858 GC08P035459 GC08P035521 GC08P033626


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UNC5D Gene: 
UNC5D (unc-5 homolog D (C. elegans)) is a protein-coding gene. Diseases associated with UNC5D include neuronitis, and among its related super-pathways are Axon guidance and DCC mediated attractive signaling. An important paralog of this gene is BAI1.

UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4
Function: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth
cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its
association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for
apoptosis induction when not associated with netrin ligand (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC5D gene promoter:
         TBP   Sox5   MEF-2   Nkx2-5   Arnt   C/EBPalpha   HEN1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): UNC5D promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC5D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

UNC5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5D gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P035183:  view genomic region     (about GC identifiers)

Start:
35,092,975 bp from pter      End:
35,654,068 bp from pter
Size:
561,094 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4 (See protein sequence)
Recommended Name: Netrin receptor UNC5D precursor  
Size: 953 amino acids; 105880 Da
Subunit: Interacts with the cytoplasmic part of DCC (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: Q8WYP7
Alternative splicing: 2 isoforms:  Q6UXZ4-1   Q6UXZ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNC5D: NX_Q6UXZ4

Explore proteomics data for UNC5D at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on cytoplasmic tyrosine residues (By similarity)
  • UniProtKB: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is
    associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UXZ4

  • UNC5D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UNC5D Protein Expression
    REFSEQ proteins: NP_543148.2  
    ENSEMBL proteins: 
     ENSP00000385143   ENSP00000392739   ENSP00000287272   ENSP00000412652   ENSP00000394303  
     ENSP00000397211  
    Reactome Protein details: Q6UXZ4
    Human Recombinant Protein Products for UNC5D: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals UNC5D Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UNC5D 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane IEA--

    UNC5D for ontologies           About GeneDecksing



    UNC5D Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    5/8 InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR007110 Ig-like_dom
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q6UXZ4

    ProtoNet protein and cluster: Q6UXZ4

    4 Blocks protein domains:
    IPB000488 Death domain
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 2 TSP type-1 domains
    Similarity: Contains 1 ZU5 domain


    UNC5D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC5D_HUMAN, Q6UXZ4
    Function: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth
    cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its
    association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for
    apoptosis induction when not associated with netrin ligand (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    UNC5D for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Unc5d):
     behavior/neurological  cellular  nervous system 

    UNC5D for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UNC5D 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UNC5D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UNC5D 

    miRNA
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    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5D (see all 81):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-30d hsa-miR-10b* hsa-miR-1304 hsa-miR-30a hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UNC5D About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    2Netrin-1 signaling
    Netrin-1 signaling0.33
    3Netrin mediated repulsion signals
    Netrin mediated repulsion signals
    4Netrin Signaling
    Netrin Signaling
    5Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UNC5D
        Guidance Cues and Growth Cone Motility
    Netrin Signaling

    4        Reactome Pathways for UNC5D
        Netrin mediated repulsion signals
    Developmental Biology
    Netrin-1 signaling
    Axon guidance


    1         Kegg Pathway  (Kegg details for UNC5D):
        Axon guidance


    UNC5D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC5D

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for UNC5D (ENSP000003851434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCCENSP000003891404STRING: ENSP00000389140
    NTN1ENSP000001732294STRING: ENSP00000173229
    UNC5AENSP000003327374STRING: ENSP00000332737
    UNC5BENSP000003343294STRING: ENSP00000334329
    UNC5CENSP000004060224STRING: ENSP00000406022
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance TAS--

    UNC5D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC5D

    Search CenterWatch for drugs/clinical trials and news about UNC5D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UNC5D gene: 
    NM_080872.2  

    Unigene Cluster for UNC5D:

    Unc-5 homolog D (C. elegans)
    Hs.238889  [show with all ESTs]
    Unigene Representative Sequence: NM_080872
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404895 ENST00000420357 ENST00000287272(uc003xju.2) ENST00000416672
    ENST00000453357(uc003xjr.2 uc003xjs.2) ENST00000474634(uc003xjt.1)
    ENST00000449677
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5D
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5D (see all 81):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-30d hsa-miR-10b* hsa-miR-1304 hsa-miR-30a hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5D
    Sirion Biotech Customized lentivirus for stable overexpression of UNC5D 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5D

    Additional mRNA sequence: 

    AB055056.1 AB073394.1 AF466364.1 AK092313.1 AK122610.1 AK122615.1 AY358147.1 

    7 DOTS entries:

    DT.211429  DT.97824070  DT.101960734  DT.101973919  DT.101983794  DT.100642490  DT.101983796 

    24/49 AceView cDNA sequences (see all 49):

    AI802048 AB055056 BM021445 CK904280 BM726542 D38687 AA872790 BM021175 
    NM_080872 AA878235 AK122615 AY358147 CD672650 AK122610 AK092313 BE673998 
    BM702977 AI912801 BE670455 AI004193 AL120370 BU729454 CD644502 BM354022 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5D    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                                              -           -                                                   
    SP2:                                                                          -                                                   
    SP3:                                                  -           -                                                               


    ECgene alternative splicing isoforms for UNC5D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC5D expression in normal human tissues (normalized intensities)      UNC5D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UNC5D Expression
    About this image


    UNC5D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (WA09)
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    See UNC5D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC5D

    SOURCE GeneReport for Unigene cluster: Hs.238889
        SABiosciences Custom PCR Arrays for UNC5D
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UNC5D gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc5d1 , 5 unc-5 homolog D (C. elegans)1, 5 90.15(n)1
    96.64(a)1
      8 (16.47 cM)5
    2108011  NM_153135.31  NP_694775.11 
     286467175 
    chicken
    (Gallus gallus)
    Aves UNC5D1 unc-5 homolog D (C. elegans) 80.01(n)
    88.47(a)
      426920  XM_424529.3  XP_424529.3 
    lizard
    (Anolis carolinensis)
    Reptilia UNC5D6
    unc-5 homolog D (C. elegans)
    83(a)
    1 ↔ 1
    GL343238.1(1782641-2150819)
    zebrafish
    (Danio rerio)
    Actinopterygii unc5da1 unc-5 homolog Da (C. elegans) 67.83(n)
    69.03(a)
      566274  XM_003200856.1  XP_003200904.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta unc-56
    unc-5
    22(a)
    1 → many
    2R(11237659-11255807)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-53 axon guidance protein 26(a)   IV(5496120-5516454)   --


    ENSEMBL Gene Tree for UNC5D (if available)
    TreeFam Gene Tree for UNC5D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC5D gene
    BAI12  UNC5B2  UNC5CL2  UNC5C2  CFP2  BAI32  BAI22  UNC5A2  
    3 SIMAP similar genes for UNC5D using alignment to 5 protein entries:     UNC5D_HUMAN (see all proteins):
    UNC5B    UNC5C    UNC5A

    UNC5D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/10128 SNPs in UNC5D are shown (see all 10128)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383670961,2
    C--33720401(+) GGTTG-/ATAT  
      ATATAT
    ATATA
    1 -- int10--------
    rs1452368941,2
    --35090984(+) ATTTGA/GTAGAT 1 -- us2k10--------
    rs1876284151,2
    --35091132(+) TCTTGA/CCTAGG 1 -- us2k10--------
    rs1448673061,2
    --35091174(+) CGGAGC/GAAACA 1 -- us2k10--------
    rs774691571,2
    --35091205(+) TTCACG/TTGTCT 1 -- us2k10--------
    rs1431677041,2
    --35091349(+) ACTGTA/TTATTC 1 -- us2k10--------
    rs1482531561,2
    --35091536(+) GGACTC/GGATCC 1 -- us2k10--------
    rs105951551,2
    C--35091736(+) CACTT-/A/AA  
            
    AAAAA
    1 -- us2k1 trp32NA 4
    rs1413135371,2
    C--35091837(+) ATGAGA/GCCACA 1 -- us2k10--------
    rs1915046081,2
    C--35091941(+) CATCAA/GACAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC5D (35092975 - 35342975 bp, first 250kb of UNC5D)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for UNC5D (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2736875CNV Deletion23290073
    esv2663137CNV Deletion23128226
    esv2532641CNV Deletion19546169
    esv2483846CNV Deletion19546169
    esv2657552CNV Deletion23128226
    esv2530621CNV Deletion19546169
    dgv1279e199CNV Deletion23128226
    esv1962769CNV Deletion18987734
    esv2675242CNV Deletion23128226
    esv2632134CNV Insertion19546169

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for UNC5D:    About MalaCards
    neuronitis    


    UNC5D for disorders           About GeneDecksing

    Genetic Association Database (GAD): UNC5D
    Human Genome Epidemiology (HuGE) Navigator: UNC5D (1 document)

    Export disorders for UNC5D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC5D gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with UNC5D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. (PubMed id 18402767)1, 3 Wang H....Nakagawara A. (2008)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    5. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....Munafo M.R. (2010)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    7. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    8. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (2006)
    9. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
    10. Identification of the genes that are expressed in the upper layers of the neocortex. (PubMed id 15142956)1 Zhong Y....Yamamoto N. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 137970 HGNC: 18634 AceView: UNC5D Ensembl:ENSG00000156687 euGenes: HUgn137970
    ECgene: UNC5D Kegg: 137970 H-InvDB: UNC5D

    (According to HUGE)
    About This Section
    HUGE: KIAA1777

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC5D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UNC5D gene:
    Search GeneIP for patents involving UNC5D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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