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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC5D Gene

protein-coding   GIFtS: 53
GCID: GC08P035183

unc-5 homolog D (C. elegans)
 Explore 1 disease affiliated with
UNC5D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UNC5D    

Aliases
for UNC5D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Unc-5 Homolog D (C. Elegans)1 2     PRO346922
Unc5h41 2     Netrin Receptor UNC5D2
KIAA17771 3     Netrin Receptor Unc5h42
Protein Unc-5 Homolog 42 3     Unc-5 Homolog 42
Protein Unc-5 Homolog D2 3     UNC5H43

External Ids:    HGNC: 186341   Entrez Gene: 1379702   Ensembl: ENSG000001566877   UniProtKB: Q6UXZ43   

Export aliases for UNC5D gene to outside databases

Previous GC identifers: GC08P035858 GC08P035459 GC08P035521 GC08P033626


Summaries
for UNC5D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4
Function: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in
the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
induction when not associated with netrin ligand (By similarity)




Genomic Views
for UNC5D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC5D gene promoter:
         TBP   Sox5   MEF-2   Nkx2-5   Arnt   C/EBPalpha   HEN1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): UNC5D promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC5D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

UNC5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5D gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P035183:  view genomic region     (about GC identifiers)

Start:
 35,092,975 bp from pter      End:
 35,654,068 bp from pter
Size:
 561,094 bases      Orientation:
 plus strand

Proteins
for UNC5D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4 (See protein sequence)
Recommended Name: Netrin receptor UNC5D precursor  
Size: 953 amino acids; 105880 Da
Subunit: Interacts with the cytoplasmic part of DCC (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: Q8WYP7
Alternative splicing: 2 isoforms:  Q6UXZ4-1   Q6UXZ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNC5D: NX_Q6UXZ4

Post-translational modifications:

  • Phosphorylated on cytoplasmic tyrosine residues (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated
    • with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UXZ4

    • UNC5D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_543148.2  
    ENSEMBL proteins: 
     ENSP00000385143   ENSP00000392739   ENSP00000287272   ENSP00000412652   ENSP00000394303  
     ENSP00000397211  
    Reactome Protein details: Q6UXZ4
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UNC5D (UNC5H4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for UNC5D 
    GenScript Custom Purified and Recombinant Proteins Services for UNC5D
    Novus Biologicals UNC5D Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UNC5D

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane IEA--


    UNC5D for ontologies           About GeneDecksing



    UNC5D Antibody Products: 
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    Uscn Antibodies for UNC5D
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    Assay Products for UNC5D: 
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    Uscn ELISAs and CLIAs for UNC5D

    Protein Domains /
    Families
    for UNC5D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UNC5D for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR007110 Ig-like_dom
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q6UXZ4

    ProtoNet protein and cluster: Q6UXZ4

    4 Blocks protein families:
    IPB000488 Death domain
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 2 TSP type-1 domains
    Similarity: Contains 1 ZU5 domain


    Function
    for UNC5D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UNC5D_HUMAN, Q6UXZ4
    Function: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in
    the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
    with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
    induction when not associated with netrin ligand (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: UNC5D
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5D
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5D (see all 81):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-30d hsa-miR-10b* hsa-miR-1304 hsa-miR-30a hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC5D (see all 4)
    OriGene shRNA RFP: UNC5D
    OriGene siRNA: UNC5D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5D

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UNC5D

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC5D (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC5D (see all 2)
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5D 

    Cell Line
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    Search LifeMap BioReagents cell lines for UNC5D

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5D

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----


    UNC5D for ontologies           About GeneDecksing



    Pathways & Interactions
    for UNC5D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Netrin mediated repulsion signals
    		Netrin mediated repulsion signals1.00
    3Netrin Signaling
    		Netrin Signaling1.00
    4Guidance Cues and Growth Cone Motility
    		Guidance Cues and Growth Cone Motility1.00
    5Axon guidance
    		Axon guidance1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UNC5D
        Guidance Cues and Growth Cone Motility
    Netrin Signaling

    4        Reactome Pathways for UNC5D
        Netrin mediated repulsion signals
    Developmental Biology
    Netrin-1 signaling
    Axon guidance


    1         Kegg Pathway  (Kegg details for UNC5D):
        Axon guidance


    UNC5D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC5D

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for UNC5D (ENSP000003851434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCCENSP000003891404STRING: ENSP00000389140
    NTN1ENSP000001732294STRING: ENSP00000173229
    UNC5AENSP000003327374STRING: ENSP00000332737
    UNC5BENSP000003343294STRING: ENSP00000334329
    UNC5CENSP000004060224STRING: ENSP00000406022
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance TAS--


    UNC5D for ontologies           About GeneDecksing



    Drugs & Compounds
    for UNC5D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC5D
    Search CenterWatch for drugs/clinical trials and news about UNC5D 

    Transcripts
    for UNC5D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UNC5D gene: 
    NM_080872.2  

    Unigene Cluster for UNC5D:

    Unc-5 homolog D (C. elegans)
    Hs.238889  [show with all ESTs]
    Unigene Representative Sequence: NM_080872
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404895 ENST00000420357 ENST00000287272(uc003xju.2) ENST00000416672
    ENST00000453357(uc003xjr.2 uc003xjs.2) ENST00000474634(uc003xjt.1)
    ENST00000449677

    miRNA
    Products:             		 OriGene 3'-UTR Clone: UNC5D
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5D
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5D (see all 81):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-30d hsa-miR-10b* hsa-miR-1304 hsa-miR-30a hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC5D (see all 4)
    OriGene shRNA RFP: UNC5D
    OriGene siRNA: UNC5D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5D
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC5D (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC5D (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UNC5D (NM_080872)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5D 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UNC5D
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5D

    Additional cDNA sequence: 

    AB055056.1 AB073394.1 AF466364.1 AK092313.1 AK122610.1 AK122615.1 AY358147.1 

    7 DOTS entries:

    DT.211429  DT.97824070  DT.101960734  DT.101973919  DT.101983794  DT.100642490  DT.101983796 

    24/49 AceView cDNA sequences (see all 49):

    AB055056 BM021175 BM021445 CK904280 BM726542 AA872790 D38687 AI802048 
    AK092313 AK122615 AA878235 AK122610 CD672650 BM702977 BE673998 AI912801 
    AY358147 NM_080872 CD636011 AI004193 BU729454 BE670455 AI972558 AL120369 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5D    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                                              -           -                                                   
    SP2:                                                                          -                                                   
    SP3:                                                  -           -                                                               


    ECgene alternative splicing isoforms for UNC5D

    Expression
    for UNC5D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC5D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UNC5D expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)

    See UNC5D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC5D

    SOURCE GeneReport for Unigene cluster: Hs.238889
        SABiosciences Custom PCR Arrays for UNC5D
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5D
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5D
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5D

    Orthologs
    for UNC5D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UNC5D gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UNC5D1 unc-5 homolog D (C. elegans) 80.01(n)
    88.47(a)    		   426920  XM_424529.3  XP_424529.3 
    lizard
    (Anolis carolinensis)    		 Reptilia UNC5D6
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL343238.1(1953200-2150819)
    zebrafish
    (Danio rerio)    		 Actinopterygii unc5da1 unc-5 homolog Da (C. elegans) 67.83(n)
    69.03(a)    		   566274  XM_003200856.1  XP_003200904.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta unc-56
    		 unc-5
    		 22(a)
    		 1 → many
    		 2R(11237659-11255807)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-53 axon guidance protein 26(a)   IV(5496120-5516454)   --


    ENSEMBL Gene Tree for UNC5D (if available)
    TreeFam Gene Tree for UNC5D (if available) 

    Paralogs
    for UNC5D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC5D gene
    UNC5B2  BAI12  UNC5C2  UNC5A2  UNC5CL2  CFP2  BAI32  BAI22  
    3 SIMAP similar genes for UNC5D using alignment to 5 protein entries:     UNC5D_HUMAN (see all proteins):
    UNC5B    UNC5C    UNC5A

    UNC5D for paralogs           About GeneDecksing



    Genomic Variants
    for UNC5D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8528 NCBI SNPs in UNC5D are shown (see all 8528)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1452368941,2
    		--35090984(+) ATTTGA/GTAGAT 1 -- us2k10--------
    rs1876284151,2
    		--35091132(+) TCTTGA/CCTAGG 1 -- us2k10--------
    rs1448673061,2
    		--35091174(+) CGGAGC/GAAACA 1 -- us2k10--------
    rs774691571,2
    		--35091205(+) TTCACG/TTGTCT 1 -- us2k10--------
    rs1431677041,2
    		--35091349(+) ACTGTA/TTATTC 1 -- us2k10--------
    rs1482531561,2
    		--35091536(+) GGACTC/GGATCC 1 -- us2k10--------
    rs105951551,2
    		C--35091736(+) CACTT-/AAAAAAA 1 -- us2k1 trp32Minor allele frequency- AA:0.25NA 4
    rs1413135371,2
    		--35091837(+) ATGAGA/GCCACA 1 -- us2k10--------
    rs1915046081,2
    		--35091941(+) CATCAA/GACAGT 1 -- us2k10--------
    rs1442807901,2
    		C,--35092057(+) CCCCC-/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC5D (35092975 - 35342975 bp, first 250kb of UNC5D)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for UNC5D
         6 CNVs: 65108 82561 95366 100317 82560 65107
         5 Indels: 100318 100319 13049 59469 47532

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    Disorders / Diseases
    for UNC5D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UNC5D for disorders           About GeneDecksing

    1 disease for UNC5D:    About MalaCards
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: UNC5D (1 document)

    Export disorders for UNC5D gene to outside databases

    Publications
    for UNC5D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC5D gene integrated from 9 sources:
    (articles sorted by number of sources associating them with UNC5D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. (PubMed id 18402767)1, 3 Wang H....Nakagawara A. (2008)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (2006)
    5. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
    6. Identification of the genes that are expressed in the upper layers of the neocortex. (PubMed id 15142956)1 Zhong Y....Yamamoto N. (2004)
    7. The cortical subventricular zone-specific molecule Svet1 is part of the nuclear RNA coded by the putative netrin receptor gene Unc5d and is expressed in multipolar migrating cells. (PubMed id 18547816)9 Sasaki S....Nakajima K. (2008)
    8. Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos. (PubMed id 19492039)9 Karaulanov E....Niehrs C. (2009)

    External Searches for UNC5D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UNC5D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 137970 HGNC: 18634 AceView: UNC5D Ensembl:ENSG00000156687 euGenes: HUgn137970
    ECgene: UNC5D Kegg: 137970 H-InvDB: UNC5D

    Other Databases showing UNC5D gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1777

    Specialized Databases showing UNC5D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC5D Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UNC5D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UNC5D gene:
    Search GeneIP for patents involving UNC5D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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