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Aliases for UNC5CL Gene

Aliases for UNC5CL Gene

  • Unc-5 Homolog C (C. Elegans)-Like 2 3
  • ZU5 And Death Domain Containing 2 3
  • Protein Unc-5 Homolog C-Like 3 4
  • ZUD 3 4
  • ZU5 And Death Domain-Containing Protein 4
  • UNC5C-Like Protein 3
  • MUXA 3

External Ids for UNC5CL Gene

Previous GeneCards Identifiers for UNC5CL Gene

  • GC06M040996
  • GC06M041042
  • GC06M041043
  • GC06M041102
  • GC06M040712

Summaries for UNC5CL Gene

GeneCards Summary for UNC5CL Gene

UNC5CL (Unc-5 Homolog C (C. Elegans)-Like) is a Protein Coding gene. Among its related pathways are Netrin Signaling and TNF-alpha/NF-kB Signaling Pathway. An important paralog of this gene is UNC5D.

UniProtKB/Swiss-Prot for UNC5CL Gene

  • Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5CL Gene

Genomics for UNC5CL Gene

Regulatory Elements for UNC5CL Gene

Genomic Location for UNC5CL Gene

Start:
41,026,901 bp from pter
End:
41,039,217 bp from pter
Size:
12,317 bases
Orientation:
Minus strand

Genomic View for UNC5CL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNC5CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5CL Gene

Proteins for UNC5CL Gene

  • Protein details for UNC5CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV45-UN5CL_HUMAN
    Recommended name:
    UNC5C-like protein
    Protein Accession:
    Q8IV45
    Secondary Accessions:
    • Q5TGU1

    Protein attributes for UNC5CL Gene

    Size:
    518 amino acids
    Molecular mass:
    57818 Da
    Quaternary structure:
    • Interacts with p65/RELA and NFKB1.

neXtProt entry for UNC5CL Gene

Proteomics data for UNC5CL Gene at MOPED

Post-translational modifications for UNC5CL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC5CL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC5CL Gene

Domains for UNC5CL Gene

Protein Domains for UNC5CL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UNC5CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IV45

UniProtKB/Swiss-Prot:

UN5CL_HUMAN :
  • Q8IV45
Domain:
  • Contains 1 death domain.
  • Contains 1 ZU5 domain.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5CL: view

No data available for Gene Families for UNC5CL Gene

Function for UNC5CL Gene

Molecular function for UNC5CL Gene

UniProtKB/Swiss-Prot Function: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.

Gene Ontology (GO) - Molecular Function for UNC5CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008233 peptidase activity IDA 22158417
genes like me logo Genes that share ontologies with UNC5CL: view

miRNA for UNC5CL Gene

miRTarBase miRNAs that target UNC5CL

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UNC5CL Gene

Localization for UNC5CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5CL Gene

Membrane; Single-pass type III membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5CL Gene COMPARTMENTS Subcellular localization image for UNC5CL gene
Compartment Confidence
cytoskeleton 3
extracellular 3
chloroplast 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UNC5CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 22158417
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC5CL: view

Pathways for UNC5CL Gene

genes like me logo Genes that share pathways with UNC5CL: view

Pathways by source for UNC5CL Gene

1 Qiagen pathway for UNC5CL Gene
1 BioSystems pathway for UNC5CL Gene

Gene Ontology (GO) - Biological Process for UNC5CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 22158417
GO:0007165 signal transduction IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 22158417
GO:0046330 positive regulation of JNK cascade IDA 22158417
genes like me logo Genes that share ontologies with UNC5CL: view

Transcripts for UNC5CL Gene

mRNA/cDNA for UNC5CL Gene

Unigene Clusters for UNC5CL Gene

Unc-5 homolog C (C. elegans)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5CL Gene

No ASD Table

Relevant External Links for UNC5CL Gene

GeneLoc Exon Structure for
UNC5CL
ECgene alternative splicing isoforms for
UNC5CL

Expression for UNC5CL Gene

mRNA expression in normal human tissues for UNC5CL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5CL Gene

This gene is overexpressed in Kidney - Cortex (14.6), Liver (10.7), and Pancreas (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UNC5CL Gene

SOURCE GeneReport for Unigene cluster for UNC5CL Gene Hs.158357

mRNA Expression by UniProt/SwissProt for UNC5CL Gene

Q8IV45-UN5CL_HUMAN
Tissue specificity: Expressed in pancreas, liver and kidney.
genes like me logo Genes that share expressions with UNC5CL: view

Orthologs for UNC5CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for UNC5CL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC5CL 35
  • 99.61 (n)
  • 99.81 (a)
UNC5CL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC5CL 35
  • 86.68 (n)
  • 87.45 (a)
UNC5CL 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC5CL 35
  • 87.4 (n)
  • 89.73 (a)
UNC5CL 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc5cl 35
  • 82.88 (n)
  • 83.98 (a)
Unc5cl 16
Unc5cl 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNC5CL 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Unc5cl 35
  • 80.53 (n)
  • 80.34 (a)
zebrafish
(Danio rerio)
Actinopterygii bai2 36
  • 11 (a)
OneToOne
Species with no ortholog for UNC5CL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UNC5CL Gene

ENSEMBL:
Gene Tree for UNC5CL (if available)
TreeFam:
Gene Tree for UNC5CL (if available)

Paralogs for UNC5CL Gene

Paralogs for UNC5CL Gene

Selected SIMAP similar genes for UNC5CL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNC5CL: view

Variants for UNC5CL Gene

Sequence variations from dbSNP and Humsavar for UNC5CL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs736793 -- 41,030,180(+) AATTG(A/T)GCACC intron-variant
rs736794 -- 41,030,094(-) AGGAG(A/C)AAGAC intron-variant
rs736795 -- 41,030,402(+) ATGCC(A/G)CAAAG reference, synonymous-codon
rs742491 -- 41,028,434(+) GGCCT(C/G)GGCTG reference, missense
rs742492 -- 41,028,642(+) GGAGG(A/G)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5CL Gene

Variant ID Type Subtype PubMed ID
nsv526577 CNV Loss 19592680

Relevant External Links for UNC5CL Gene

HapMap Linkage Disequilibrium report
UNC5CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5CL Gene

Disorders for UNC5CL Gene

No disorders were found for UNC5CL Gene.

No data available for UniProtKB/Swiss-Prot for UNC5CL Gene

Publications for UNC5CL Gene

  1. Identification of a ZU5 and death domain-containing inhibitor of NF- kappaB. (PMID: 14769797) Zhang J. … Shu H.-B. (J. Biol. Chem. 2004) 2 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PMID: 21642993) Wu C. … Lin D. (Nat. Genet. 2011) 3
  4. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. (PMID: 22158417) Heinz L.X. … Tschopp J. (Cell Death Differ. 2012) 3
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for UNC5CL Gene

Sources for UNC5CL Gene

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