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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UNC5CL Gene

protein-coding GIFtS: 49
GCID: GC06M040994

unc-5 homolog C (C. elegans)-like

Explore 4 diseases affiliated with
UNC5CL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Unc-5 Homolog C (C. Elegans)-Like¹ ²		MUXA²
ZUD¹ ² ³		UNC5C-Like Protein²
Protein Unc-5 Homolog C-Like² ³		ZU5 And Death Domain Containing²
MGC34763¹		ZU5 And Death Domain-Containing Protein³

External Ids:	HGNC: 21203¹	Entrez Gene: 222643²	Ensembl: ENSG00000124602⁷	UniProtKB: Q8IV45³

Export aliases for UNC5CL gene to outside databases

Previous GC identifers: GC06M040996 GC06M041042 GC06M041043 GC06M041102 GC06M040712

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45

Function: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UNC5CL gene promoter:
HOXA9B Bach2 AP-4 CUTL1 Roaz GATA-1 NF-kappaB1 AP-2alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UNC5CL promoter sequence

Search SABiosciences Chromatin IP Primers for UNC5CL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5CL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

UNC5CL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5CL gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M040994: view genomic region (about GC identifiers)

Start:	40,994,640 bp from pter	End:	41,006,938 bp from pter
Size:	12,299 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45 (See protein sequence)

Recommended Name: UNC5C-like protein

Size: 518 amino acids; 57818 Da

Subunit: Interacts with p65/RELA and NFKB1

Subcellular location: Membrane; Single-pass type III membrane protein (Potential). Cytoplasm

Secondary accessions: Q5TGU1

Explore the universe of human proteins at neXtProt for UNC5CL: NX_Q8IV45

UNC5CL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775832.2

ENSEMBL proteins:

ENSP00000362258 ENSP00000244565

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0016021	integral to membrane	IEA	--

UNC5CL for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UNC5CL for domains About GeneDecksing

3 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR000488 Death_domain

IPR000906 ZU5

Graphical View of Domain Structure for InterPro Entry Q8IV45

ProtoNet protein and cluster: Q8IV45

1 Blocks protein family: IPB000488 Death domain

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45

Similarity: Belongs to the unc-5 family

Similarity: Contains 1 death domain

Similarity: Contains 1 ZU5 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45

Function: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Netrin Signaling

Netrin Signaling

1.00

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for UNC5CL

Netrin Signaling

1 BioSystems Pathway for UNC5CL

TNF-alpha/NF-kB Signaling Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UNC5CL

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for UNC5CL (Q8IV45³ ENSP00000244565⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838³, ENSP00000226574⁴	I2D: score=1 STRING: ENSP00000226574
RELA	Q04206³, ENSP00000384273⁴	I2D: score=1 STRING: ENSP00000384273

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--

UNC5CL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UNC5CL
Search CenterWatch for drugs/clinical trials and news about UNC5CL / UN5CL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UNC5CL gene:

NM_173561.2

Unigene Cluster for UNC5CL:

Unc-5 homolog C (C. elegans)-like

Hs.158357 [show with all ESTs]

Unigene Representative Sequence: JF681947

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373164 ENST00000470102 ENST00000244565(uc003opi.3)

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		hsa-miR-1539 hsa-miR-454*
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Additional cDNA sequence:

AY510109.1 BC035284.1 JF681947.1

3 DOTS entries:

DT.405954 DT.97799912 DT.121305296

24/34 AceView cDNA sequences (see all 34):

AI732663 BM023340 AY510109 AI283772 AW771149 AA593410 AI733001 BI963073

BC035284 CR616692 AI791395 AA865842 NM_173561 CK821802 BG564282 AI915867

AW341040 BI762014 AW300448 BX390655 BQ029052 BM311474 BX400199 CK821803

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UNC5CL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGGGCTGG

About this image

UNC5CL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Proximal Tubule

Proximal Tubule Cells

Kidney

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Bone

Cartilage

Kidney

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UNC5CL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UNC5CL

SOURCE GeneReport for Unigene cluster: Hs.158357

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45

Tissue specificity: Expressed in pancreas, liver and kidney

SABiosciences Custom PCR Arrays for UNC5CL

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for UNC5CL gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	si:ch211-80e15.1⁶	si:ch211-80e15.1		1 ↔ 1	16(40288171-40353969)
honey bee (Apis mellifera)	Insecta	--	--		1 ↔ 1	Group10.40(32917-34456)
worm (Caenorhabditis elegans)	Secernentea	mig-21⁶	Protein MIG-21	7(a)	1 ↔ 1	III(5877123-5878221)

ENSEMBL Gene Tree for UNC5CL (if available)
TreeFam Gene Tree for UNC5CL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UNC5CL gene

UNC5B² BAI1² UNC5C² UNC5A² CFP² BAI3² BAI2² UNC5D²

1 SIMAP similar gene for UNC5CL using alignment to 1 protein entry: UN5CL_HUMAN:

MUXA

UNC5CL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140570960^1,2		--	40994281(+)	`CCTGAA/GCTAAG`	1	--	ds500¹		0	--	--	--	--
rs182162470^1,2		--	40994299(+)	`GGAAAA/TGTCCG`	1	--	ds500¹		0	--	--	--	--
rs10155663^1,2	C,F,A,	--	40994301(+)	`AAAAGT/GCCGGG`	1	--	ds500¹		8		NA WA EA	368
rs186701528^1,2		--	40994319(+)	`TCTGGC/TGTGAC`	1	--	ds500¹		0	--	--	--	--
rs143419000^1,2		--	40994336(+)	`CACCCA/GATGGG`	1	--	ds500¹		0	--	--	--	--
rs192624197^1,2		--	40994472(+)	`CATGCA/GGGACC`	1	--	ds500¹		0	--	--	--	--
rs145562908^1,2		--	40994638(+)	`ATTTTA/CTCATT`	1	--	ds500¹		0	--	--	--	--
rs185517949^1,2		--	40994720(+)	`TGCCTA/GCCTTT`	1	--	ut3¹		0	--	--	--	--
rs188847832^1,2		--	40994721(+)	`GCCTGA/CCTTTG`	1	--	ut3¹		0	--	--	--	--
rs192810932^1,2		--	40994895(+)	`ATCCCC/TATCCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for UNC5CL (40994640 - 41006938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UNC5CL: --
Human Gene Mutation Database (HGMD): UNC5CL

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNC5CL

DNA2.0 Custom Variant and Variant Library Synthesis for UNC5CL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UNC5CL for disorders About GeneDecksing

4 diseases for UNC5CL: About MalaCards

esophageal squamous cell carcinoma squamous cell carcinoma esophagitis carcinoma

Export disorders for UNC5CL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UNC5CL gene integrated from 9 sources:
(articles sorted by number of sources associating them with UNC5CL)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a ZU5 and death domain-containing inhibitor of NF- kappaB. (PubMed id 14769797)^{1, 2, 3, 9} Zhang J.... Shu H.-B. (2004)
The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. (PubMed id 22158417)¹ Heinz L.X....Tschopp J. (2012)
Genome-wide association study identifies three new su sceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . (PubMed id 21642993)¹ Wu C....Lin D. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 222643	HGNC: 21203	AceView: UNC5CL	Ensembl:ENSG00000124602	euGenes: HUgn222643
ECgene: UNC5CL	H-InvDB: UNC5CL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UNC5CL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UNC5CL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for UNC5CL gene:
Search GeneIP for patents involving UNC5CL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UNC5CL
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNC5CL
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5CL
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5CL
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5CL
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5CL

	GenScript Custom Purified and Recombinant Proteins Services for UNC5CL		GenScript cDNA clones with any tag delivered in your preferred vector for UNC5CL
	GenScript Custom Assay Services for UNC5CL		GenScript Custom Superior Antibodies Services for UNC5CL
	GenScript Custom overexpressing Cell Line Services for UNC5CL		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in UNC5CL promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for UNC5CL at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for UNC5CL
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5CL

	SwitchGear 3'UTR luciferase reporter plasmids for UNC5CL
	SwitchGear Promoter luciferase reporter plasmids for UNC5CL

ThermoFisher Antibodies for UNC5CL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5CL

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes UNC5CL gene at Home site.

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UNC5CL Gene

unc-5 homolog C (C. elegans)-like

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UNC5CL Gene

unc-5 homolog C (C. elegans)-like

Aliasesfor UNC5CL gene

Summariesfor UNC5CL gene

Genomic Viewsfor UNC5CL gene

Proteinsfor UNC5CL gene

Protein Domains /Familiesfor UNC5CL gene

Functionfor UNC5CL gene

Pathways & Interactionsfor UNC5CL gene

Drugs & Compoundsfor UNC5CL gene

Transcriptsfor UNC5CL gene

Expression for UNC5CL gene

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Genomic Variantsfor UNC5CL gene

Disorders / Diseasesfor UNC5CL gene

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External Searches for UNC5CL gene

Genome Databases showing UNC5CL gene

Other Databases showing UNC5CL gene

Specialized Databases showing UNC5CL gene

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Aliases
for UNC5CL gene

Summaries
for UNC5CL gene

Genomic Views
for UNC5CL gene

Proteins
for UNC5CL gene

Protein Domains /
Families
for UNC5CL gene

Function
for UNC5CL gene

Pathways & Interactions
for UNC5CL gene

Drugs & Compounds
for UNC5CL gene

Transcripts
for UNC5CL gene

Expression
for UNC5CL gene

Orthologs
for UNC5CL gene

Paralogs
for UNC5CL gene

Genomic Variants
for UNC5CL gene

Disorders / Diseases
for UNC5CL gene

Publications
for UNC5CL gene

Intellectual Property
for UNC5CL gene

Products
for UNC5CL gene