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Aliases for UNC5CL Gene

Aliases for UNC5CL Gene

  • Unc-5 Family C-Terminal Like 2 3 5
  • Unc-5 Homolog C (C. Elegans)-Like 2 3
  • ZU5 And Death Domain Containing 2 3
  • Protein Unc-5 Homolog C-Like 3 4
  • ZUD 3 4
  • ZU5 And Death Domain-Containing Protein 4
  • MUXA 3

External Ids for UNC5CL Gene

Previous GeneCards Identifiers for UNC5CL Gene

  • GC06M040996
  • GC06M041042
  • GC06M041043
  • GC06M041102
  • GC06M040712

Summaries for UNC5CL Gene

GeneCards Summary for UNC5CL Gene

UNC5CL (Unc-5 Family C-Terminal Like) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and Netrin Signaling. GO annotations related to this gene include peptidase activity. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for UNC5CL Gene

  • Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5CL Gene

Genomics for UNC5CL Gene

Regulatory Elements for UNC5CL Gene

Enhancers for UNC5CL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UNC5CL on UCSC Golden Path with GeneCards custom track

Promoters for UNC5CL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UNC5CL on UCSC Golden Path with GeneCards custom track

Genomic Location for UNC5CL Gene

41,026,901 bp from pter
41,039,217 bp from pter
12,317 bases
Minus strand

Genomic View for UNC5CL Gene

Genes around UNC5CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5CL Gene

Proteins for UNC5CL Gene

  • Protein details for UNC5CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UNC5C-like protein
    Protein Accession:
    Secondary Accessions:
    • Q5TGU1

    Protein attributes for UNC5CL Gene

    518 amino acids
    Molecular mass:
    57818 Da
    Quaternary structure:
    • Interacts with p65/RELA and NFKB1.

neXtProt entry for UNC5CL Gene

Proteomics data for UNC5CL Gene at MOPED

Post-translational modifications for UNC5CL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC5CL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ZU5

No data available for DME Specific Peptides for UNC5CL Gene

Domains & Families for UNC5CL Gene

Protein Domains for UNC5CL Gene


Suggested Antigen Peptide Sequences for UNC5CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 death domain.
  • Belongs to the unc-5 family.
  • Contains 1 death domain.
  • Contains 1 ZU5 domain.
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5CL: view

No data available for Gene Families for UNC5CL Gene

Function for UNC5CL Gene

Molecular function for UNC5CL Gene

UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.
genes like me logo Genes that share phenotypes with UNC5CL: view

Animal Model Products

CRISPR Products

miRNA for UNC5CL Gene

miRTarBase miRNAs that target UNC5CL

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC5CL Gene

Localization for UNC5CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5CL Gene

Membrane; Single-pass type III membrane protein. Cytoplasm.

Subcellular locations from

Jensen Localization Image for UNC5CL Gene COMPARTMENTS Subcellular localization image for UNC5CL gene
Compartment Confidence
extracellular 3
cytoskeleton 2
chloroplast 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UNC5CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UNC5CL: view

Pathways & Interactions for UNC5CL Gene

genes like me logo Genes that share pathways with UNC5CL: view

Pathways by source for UNC5CL Gene

1 BioSystems pathway for UNC5CL Gene
1 Qiagen pathway for UNC5CL Gene

Gene Ontology (GO) - Biological Process for UNC5CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 22158417
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with UNC5CL: view

No data available for SIGNOR curated interactions for UNC5CL Gene

Drugs & Compounds for UNC5CL Gene

No Compound Related Data Available

Transcripts for UNC5CL Gene

mRNA/cDNA for UNC5CL Gene

Unigene Clusters for UNC5CL Gene

Unc-5 homolog C (C. elegans)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5CL Gene

No ASD Table

Relevant External Links for UNC5CL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNC5CL Gene

mRNA expression in normal human tissues for UNC5CL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5CL Gene

This gene is overexpressed in Kidney - Cortex (x14.6), Liver (x10.7), and Pancreas (x7.3).

Protein differential expression in normal tissues from HIPED for UNC5CL Gene

This gene is overexpressed in Plasma (34.0), Islet of Langerhans (22.1), and Kidney (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5CL Gene

SOURCE GeneReport for Unigene cluster for UNC5CL Gene Hs.158357

mRNA Expression by UniProt/SwissProt for UNC5CL Gene

Tissue specificity: Expressed in pancreas, liver and kidney.
genes like me logo Genes that share expression patterns with UNC5CL: view

Protein tissue co-expression partners for UNC5CL Gene

Primer Products

Orthologs for UNC5CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for UNC5CL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UNC5CL 35
  • 86.68 (n)
  • 87.45 (a)
  • 87 (a)
(Canis familiaris)
Mammalia UNC5CL 35
  • 87.4 (n)
  • 89.73 (a)
  • 90 (a)
(Mus musculus)
Mammalia Unc5cl 35
  • 82.88 (n)
  • 83.98 (a)
Unc5cl 16
Unc5cl 36
  • 84 (a)
(Pan troglodytes)
Mammalia UNC5CL 35
  • 99.61 (n)
  • 99.81 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Unc5cl 35
  • 80.53 (n)
  • 80.34 (a)
(Monodelphis domestica)
Mammalia UNC5CL 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
(Danio rerio)
Actinopterygii bai2 36
  • 11 (a)
Species with no ortholog for UNC5CL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UNC5CL Gene

Gene Tree for UNC5CL (if available)
Gene Tree for UNC5CL (if available)

Paralogs for UNC5CL Gene

Paralogs for UNC5CL Gene

(1) SIMAP similar genes for UNC5CL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNC5CL: view

Variants for UNC5CL Gene

Sequence variations from dbSNP and Humsavar for UNC5CL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs742493 - 41,030,428(-) GGCGC(A/G)GACTG reference, missense
rs10155663 -- 41,026,562(+) AAAAG(G/T)CCGGG downstream-variant-500B
rs6924722 -- 41,034,456(+) TTACT(A/G)GAGAA intron-variant
rs10947943 -- 41,036,354(+) GCCAC(A/G)TGTAC intron-variant
rs10947944 -- 41,036,918(+) CCACC(C/T)CCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5CL Gene

Variant ID Type Subtype PubMed ID
nsv526577 CNV Loss 19592680

Variation tolerance for UNC5CL Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UNC5CL Gene

Disorders for UNC5CL Gene

Relevant External Links for UNC5CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UNC5CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5CL Gene

Publications for UNC5CL Gene

  1. Identification of a ZU5 and death domain-containing inhibitor of NF- kappaB. (PMID: 14769797) Zhang J. … Shu H.-B. (J. Biol. Chem. 2004) 2 3 4 23 67
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  3. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. (PMID: 22158417) Heinz L.X. … Tschopp J. (Cell Death Differ. 2012) 3
  4. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PMID: 21642993) Wu C. … Lin D. (Nat. Genet. 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for UNC5CL Gene

Sources for UNC5CL Gene