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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC5CL Gene

protein-coding   GIFtS: 50
GCID: GC06M040994

Unc-5 Homolog C (C. Elegans)-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Unc-5 Homolog C (C. Elegans)-Like1 2     MUXA2
ZU5 And Death Domain Containing1 2     UNC5C-Like Protein2
Protein Unc-5 Homolog C-Like2 3     ZU5 And Death Domain-Containing Protein3
ZUD2 3     

External Ids:    HGNC: 212031   Entrez Gene: 2226432   Ensembl: ENSG000001246027   UniProtKB: Q8IV453   

Export aliases for UNC5CL gene to outside databases

Previous GC identifers: GC06M040996 GC06M041042 GC06M041043 GC06M041102 GC06M040712


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UNC5CL Gene: 
UNC5CL (unc-5 homolog C (C. elegans)-like) is a protein-coding gene. Diseases associated with UNC5CL include esophageal squamous cell carcinoma, and esophagitis. An important paralog of this gene is BAI1.

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45
Function: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC5CL gene promoter:
         HOXA9B   Bach2   AP-4   CUTL1   Roaz   GATA-1   NF-kappaB1   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC5CL promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC5CL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5CL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

UNC5CL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5CL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M040994:  view genomic region     (about GC identifiers)

Start:
40,994,640 bp from pter      End:
41,006,938 bp from pter
Size:
12,299 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45 (See protein sequence)
Recommended Name: UNC5C-like protein  
Size: 518 amino acids; 57818 Da
Subunit: Interacts with p65/RELA and NFKB1
Subcellular location: Membrane; Single-pass type III membrane protein (Potential). Cytoplasm
Secondary accessions: Q5TGU1

Explore the universe of human proteins at neXtProt for UNC5CL: NX_Q8IV45

Explore proteomics data for UNC5CL at MOPED 

UNC5CL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

UNC5CL Protein Expression

REFSEQ proteins: NP_775832.2  
ENSEMBL proteins: 
 ENSP00000362258   ENSP00000244565  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--
GO:0016021integral to membrane IEA--

UNC5CL for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR011029 DEATH-like_dom
 IPR000488 Death_domain
 IPR000906 ZU5

Graphical View of Domain Structure for InterPro Entry Q8IV45

ProtoNet protein and cluster: Q8IV45

1 Blocks protein domain: IPB000488 Death domain

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45
Similarity: Belongs to the unc-5 family
Similarity: Contains 1 death domain
Similarity: Contains 1 ZU5 domain


UNC5CL for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: UN5CL_HUMAN, Q8IV45
Function: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
UNC5CL for ontologies           About GeneDecksing


Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidUNC5CL 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for UNC5CL About                                                                                                See pathways by source

SuperPathContained pathways About
1Netrin Signaling
Netrin Signaling
2TNF-alpha/NF-kB Signaling Pathway
TNF-alpha/NF-kB Signaling Pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for UNC5CL
    Netrin Signaling

1 BioSystems Pathway for UNC5CL
    TNF-alpha/NF-kB Signaling Pathway


Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC5CL

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for UNC5CL (Q8IV453 ENSP000002445654) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
NFKB1P198383, ENSP000002265744I2D: score=1 STRING: ENSP00000226574
RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction IEA--

UNC5CL for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UNC5CL (UN5CL)

Search CenterWatch for drugs/clinical trials and news about UNC5CL / UN5CL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UNC5CL gene: 
NM_173561.2  

Unigene Cluster for UNC5CL:

Unc-5 homolog C (C. elegans)-like
Hs.158357  [show with all ESTs]
Unigene Representative Sequence: JF681947
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373164 ENST00000470102 ENST00000244565(uc003opi.3)
miRNA
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2 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5CL:
hsa-miR-1539 hsa-miR-454*
SwitchGear 3'UTR luciferase reporter plasmidUNC5CL 3' UTR sequence
Inhib. RNA
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                     Customized lentivirus expression plasmids for stable overexpression of UNC5CL 
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Additional mRNA sequence: 

AY510109.1 BC035284.1 JF681947.1 

3 DOTS entries:

DT.405954  DT.97799912  DT.121305296 

24/34 AceView cDNA sequences (see all 34):

AA865842 AI283772 AY510109 BI963073 BC035284 AI791395 BM023340 AW771149 
CR616692 AI732663 AA593410 AI733001 NM_173561 CK821802 BX400199 AI915867 
CK821803 AW300448 BG564282 BM311474 BI762014 BQ029052 BX390655 AW341040 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UNC5CL expression in normal human tissues (normalized intensities)      UNC5CL embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATGGGCTGG
UNC5CL Expression
About this image


UNC5CL expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/13 selected tissues (see all 13) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 9 entries
         Zeugopod Long Bone
         skeleton/pectoral girdle and thoracic body wall/scapula   
 
 Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
         Meckel's Cartilage
         sensory organ/ear/inner ear   
 
 Kidney (Urinary System)    fully expand to see all 3 entries
         Proximal Tubule Cells Proximal Tubule
         Proximal Tubule
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
         skeleton/cranium/chondrocranium   
 
 Nose (Sensory Organs)
         sensory organ/nose/naris   

See UNC5CL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UNC5CL

SOURCE GeneReport for Unigene cluster: Hs.158357

UniProtKB/Swiss-Prot: UN5CL_HUMAN, Q8IV45
Tissue specificity: Expressed in pancreas, liver and kidney

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5CL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for UNC5CL gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Unc5cl1 , 5 unc-5 homolog C (C. elegans)-like1, 5 82.88(n)1
83.98(a)1
  17 (24.14 cM)5
765891  NM_152823.41  NP_690036.41 
 484549015 
worm
(Caenorhabditis elegans)
Secernentea mig-216
Protein MIG-21, isoform b
9(a)
1 ↔ 1
III(5877013-5878419)


ENSEMBL Gene Tree for UNC5CL (if available)
TreeFam Gene Tree for UNC5CL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for UNC5CL gene
BAI12  UNC5B2  UNC5C2  CFP2  BAI32  BAI22  UNC5A2  UNC5D2  
1 SIMAP similar gene for UNC5CL using alignment to 1 protein entry:     UN5CL_HUMAN:
MUXA

UNC5CL for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/324 SNPs in UNC5CL are shown (see all 324)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1405709601,2
--40994281(+) CCTGAA/GCTAAG 1 -- ds50010--------
rs1821624701,2
--40994299(+) GGAAAA/TGTCCG 1 -- ds50010--------
rs101556631,2
C,F,A--40994301(+) AAAAGT/GCCGGG 1 -- ds50018Minor allele frequency- G:0.28NA WA EA 368
rs1867015281,2
--40994319(+) TCTGGC/TGTGAC 1 -- ds50010--------
rs1434190001,2
--40994336(+) CACCCA/GATGGG 1 -- ds50010--------
rs1926241971,2
--40994472(+) CATGCA/GGGACC 1 -- ds50010--------
rs1455629081,2
--40994638(+) ATTTTA/CTCATT 1 -- ds50010--------
rs1855179491,2
--40994720(+) TGCCTA/GCCTTT 1 -- ut310--------
rs1888478321,2
--40994721(+) GCCTGA/CCTTTG 1 -- ut310--------
rs1928109321,2
--40994895(+) ATCCCC/TATCCT 1 -- ut310--------

HapMap Linkage Disequilibrium report for UNC5CL (40994640 - 41006938 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for UNC5CL:    About this table     
Variant IDTypeSubtypePubMed ID
nsv526577CNV Loss19592680


Human Gene Mutation Database (HGMD): UNC5CL
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing UNC5CL
DNA2.0 Custom Variant and Variant Library Synthesis for UNC5CL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for UNC5CL:    About MalaCards
esophageal squamous cell carcinoma    esophagitis    squamous cell carcinoma


UNC5CL for disorders           About GeneDecksing


Export disorders for UNC5CL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for UNC5CL gene integrated from 9 sources:
(articles sorted by number of sources associating them with UNC5CL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a ZU5 and death domain-containing inhibitor of NF- kappaB. (PubMed id 14769797)1, 2, 3, 9 Zhang J.... Shu H.-B. (2004)
  2. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
  3. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. (PubMed id 22158417)1 Heinz L.X....Tschopp J. (2012)
  4. Genome-wide association study identifies three new su sceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . (PubMed id 21642993)1 Wu C....Lin D. (2011)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 222643 HGNC: 21203 AceView: UNC5CL Ensembl:ENSG00000124602 euGenes: HUgn222643
ECgene: UNC5CL H-InvDB: UNC5CL

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for UNC5CL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for UNC5CL gene:
Search GeneIP for patents involving UNC5CL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for UNC5CL
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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