Aliases for UNC5C Gene
External Ids for UNC5C Gene
Previous GeneCards Identifiers for UNC5C Gene
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]
GeneCards Summary for UNC5C Gene
UNC5C (Unc-5 Netrin Receptor C) is a Protein Coding gene. Diseases associated with UNC5C include Hereditary Colorectal Cancer. Among its related pathways are Developmental Biology and Netrin Signaling. GO annotations related to this gene include netrin receptor activity. An important paralog of this gene is UNC5B.
UniProtKB/Swiss-Prot for UNC5C Gene
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.