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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC5C Gene

protein-coding   GIFtS: 62
GCID: GC04M096083

unc-5 homolog C (C. elegans)

(Previous name: unc5 (C.elegans homolog) c )
 Explore 12 diseases affiliated with
UNC5C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UNC5C    

Aliases
for UNC5C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Unc-5 Homolog C (C. Elegans)1 2     Protein Unc-5 Homolog C2 3
UNC5H32 3 5     Netrin Receptor UNC5C2
Unc5 (C.Elegans Homolog) C1 2     Unc-5 Homolog 32
Protein Unc-5 Homolog 32 3     

External Ids:    HGNC: 125691   Entrez Gene: 86332   Ensembl: ENSG000001821687   OMIM: 6036105   UniProtKB: O951853   

Export aliases for UNC5C gene to outside databases

Previous GC identifers: GC04M096436 GC04M096548 GC04M096446 GC04M096308 GC04M091820


Summaries
for UNC5C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UNC5C:
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon
extension and cell migration during neural development. They are bifunctional proteins that act as attractants for
some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of
receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins
containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with
DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of
DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By
similarity)

Gene Wiki entry for UNC5C


Genomic Views
for UNC5C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC5C gene promoter:
         c-Fos   TBP   AP-1   FosB   Lmo2   RORalpha1   POU2F1   TFIID   Zic1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UNC5C promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC5C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21-q23   Ensembl cytogenetic band:  4q22.3   HGNC cytogenetic band: 4q21-q23

UNC5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5C gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M096083:  view genomic region     (about GC identifiers)

Start:
 96,083,655 bp from pter      End:
 96,470,361 bp from pter
Size:
 386,707 bases      Orientation:
 minus strand

Proteins
for UNC5C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185 (See protein sequence)
Recommended Name: Netrin receptor UNC5C precursor  
Size: 931 amino acids; 103146 Da
Subunit: Interacts with the cytoplasmic part of DCC (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney
cancers
Secondary accessions: Q8IUT0
Alternative splicing: 2 isoforms:  O95185-1   O95185-2   

Explore the universe of human proteins at neXtProt for UNC5C: NX_O95185

Post-translational modifications:

  • Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with
    • PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine
    phosphorylation is netrin-dependent (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated
    • with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95185

    • UNC5C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003719.3  
    ENSEMBL proteins: 
     ENSP00000406022   ENSP00000426924   ENSP00000426153   ENSP00000425117  
    Reactome Protein details: O95185
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UNC5C (UNC5H3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: UNC5C
    OriGene Protein Over-expression Lysate: UNC5C
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    Novus Biologicals UNC5C Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UNC5C

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    UNC5C for ontologies           About GeneDecksing



    UNC5C Antibody Products: 
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    Uscn ELISAs and CLIAs for UNC5C

    Protein Domains /
    Families
    for UNC5C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UNC5C for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR007110 Ig-like_dom
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry O95185

    ProtoNet protein and cluster: O95185

    2 Blocks protein families:
    IPB000488 Death domain
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 2 TSP type-1 domains
    Similarity: Contains 1 ZU5 domain


    Function
    for UNC5C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185
    Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
    developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with
    DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of
    DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By
    similarity)

         Genatlas biochemistry entry for UNC5C:
    C elegans Unc5 and murine unc5hr homolog,involved in cell migration during cerebellum development,inducing repulsion in
    axon guidance through its cytoplasmic tail,expressed in brain,fetal heart

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5C
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5C (see all 115):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-1245 hsa-miR-200a hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: UNC5C 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC5C (see all 7)
    OriGene shRNA RFP: UNC5C
    OriGene siRNA: UNC5C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5C

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UNC5C

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC5C (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5C 

    Cell Line
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    Search LifeMap BioReagents cell lines for UNC5C

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005042netrin receptor activity IEA--


    UNC5C for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for UNC5C:
     Decreased Wnt reporter activit  Decreased nuclei size in G2M 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Unc5c):
     behavior/neurological  cellular  growth/size  mortality/aging  nervous system 
     reproductive system 

    UNC5C for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UNC5C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Netrin mediated repulsion signals
    		Netrin mediated repulsion signals1.00
    3Netrin Signaling
    		Netrin Signaling1.00
    4Guidance Cues and Growth Cone Motility
    		Guidance Cues and Growth Cone Motility1.00
    5Axon guidance
    		Axon guidance1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UNC5C
        Guidance Cues and Growth Cone Motility
    Netrin Signaling

    4        Reactome Pathways for UNC5C
        Netrin mediated repulsion signals
    Developmental Biology
    Netrin-1 signaling
    Axon guidance


    1         Kegg Pathway  (Kegg details for UNC5C):
        Axon guidance


    UNC5C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UNC5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for UNC5C (O951853 ENSP000004060224) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTN1O956313, ENSP000001732294I2D: score=1 STRING: ENSP00000173229
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    DAPK1P533553, ENSP000003507854I2D: score=1 STRING: ENSP00000350785
    DCCENSP000003891404STRING: ENSP00000389140
    FYNENSP000003576564STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007411axon guidance TAS--
    GO:0007420brain development IEA--
    GO:0030334regulation of cell migration IEA--
    GO:0038007netrin-activated signaling pathway ----


    UNC5C for ontologies           About GeneDecksing



    Drugs & Compounds
    for UNC5C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC5C
    Search CenterWatch for drugs/clinical trials and news about UNC5C 

    Transcripts
    for UNC5C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UNC5C gene: 
    NM_003728.3  

    Unigene Cluster for UNC5C:

    Unc-5 homolog C (C. elegans)
    Hs.388565  [show with all ESTs]
    Unigene Representative Sequence: NM_003728
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453304(uc003hto.3 uc010ilc.2) ENST00000513796 ENST00000506749(uc003htq.3)
    ENST00000504962

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5C
    8/115 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5C (see all 115):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-1245 hsa-miR-200a hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: UNC5C 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC5C (see all 7)
    OriGene shRNA RFP: UNC5C
    OriGene siRNA: UNC5C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5C
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC5C (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UNC5C (NM_003728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5C 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5C

    Additional cDNA sequence: 

    AF055634.1 AK022487.1 AK290500.1 AK308421.1 BC034747.1 BC041156.1 BX538341.1 

    6 DOTS entries:

    DT.311753  DT.40112526  DT.101976897  DT.404930  DT.308302  DT.95363749 

    16 AceView cDNA sequences:

    AI677642 AW078867 BX280911 AF055634 NM_003728 AA348167 AI621080 CD617402 
    BC041156 AL119797 AI917731 AI187839 BE700724 T09065 BF037457 BI769500 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5C    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                    -                             -                       -                                       
    SP2:                    -                                                                                             
    SP3:                                                                                                                  


    ECgene alternative splicing isoforms for UNC5C

    Expression
    for UNC5C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAAAATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UNC5C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    PlacentaChorioallantoic PlacentaExtraembryonic AngioblastsEndothelium
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    BoneMandibular ProcessBone
    SomiteLumbar Vertebral BodySomite
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See UNC5C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC5C

    SOURCE GeneReport for Unigene cluster: Hs.388565

    UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185
    Tissue specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung

        SABiosciences Custom PCR Arrays for UNC5C
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5C

    Orthologs
    for UNC5C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UNC5C gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UNC5C1 unc-5 homolog C (C. elegans) 82.46(n)
    92.7(a)    		   395101  NM_204451.1  NP_989782.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UNC5C6
    		 --
    		 91(a)
    		 1 ↔ 1
    		 5(49445530-49588344)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.145722 Transcribed sequence with moderate similarity to protein refNP_003719.2 (H.sapiens) unc5 (C.elegans homolog) c; homolog of C. elegans transmembrane receptor Unc5 [Homo sapiens] less 79.49(n)    BI533575.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta unc-51 , 3 axon guidance netrin receptor3
    CG8166-PA1    		 28(a)3
    44.22(n)1
    33.85(a)1    		   367031  NM_137189.21  NP_611033.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-53 axon guidance protein 28(a)   IV(5496120-5516454)   --


    ENSEMBL Gene Tree for UNC5C (if available)
    TreeFam Gene Tree for UNC5C (if available) 

    Paralogs
    for UNC5C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC5C gene
    UNC5B2  BAI12  UNC5A2  UNC5CL2  CFP2  BAI32  BAI22  UNC5D2  
    4 SIMAP similar genes for UNC5C using alignment to 4 protein entries:     UNC5C_HUMAN (see all proteins):
    UNC5B    UNC5A    UNC5D    CFP

    UNC5C for paralogs           About GeneDecksing



    Genomic Variants
    for UNC5C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for UNC5C
         2 CNVs: 98803 63898
         5 Indels: 51497 68771 41789 46725 27750
    Human Gene Mutation Database (HGMD): UNC5C
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNC5C
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC5C

    Disorders / Diseases
    for UNC5C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UNC5C for disorders           About GeneDecksing

    OMIM gene information: 603610    OMIM disorders: --

    12 diseases for UNC5C:    About MalaCards
    familial colorectal cancer    renal cell carcinoma    rheumatoid arthritis    colorectal cancer
    parkinson's disease    kidney cancer    colon cancer    arthritis
    osteoarthritis    schizophrenia    carcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: UNC5C (7 documents)

    Export disorders for UNC5C gene to outside databases

    Publications
    for UNC5C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC5C gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with UNC5C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. (PubMed id 9782087)1, 2, 3, 9 Ackerman S.L. and Knowles B.B. (1998)
    2. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 9 Thiebault K.... Mehlen P. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer. (PubMed id 19331160)1, 9 Hibi K....Sanada Y. (2009)
    5. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. (PubMed id 18054557)1, 9 Shin S.K....Goel A. (2007)
    6. Changes in UNC5C gene methylation during human gastri c carcinogenesis. (PubMed id 20032384)1, 9 Hibi K....Sanada Y. (2009)
    7. Down syndrome cell adhesion molecule (DSCAM) associate s with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. (PubMed id 22685302)1 Purohit A.A....Liu G. (2012)
    8. Variants in the netrin-1 receptor UNC5C prevent apopt osis and increase risk of familial colorectal cancer. (PubMed id 21893118)1 Coissieux M.M....Mehlen P. (2011)
    9. Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma. (PubMed id 21600761)1 Lv D....Zhang J. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for UNC5C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    Genome Databases showing UNC5C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8633 HGNC: 12569 AceView: UNC5C Ensembl:ENSG00000182168 euGenes: HUgn8633
    ECgene: UNC5C Kegg: 8633 H-InvDB: UNC5C

    Other Databases showing UNC5C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UNC5C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC5C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UNC5C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UNC5C gene:
    Search GeneIP for patents involving UNC5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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