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Aliases for UNC5C Gene

Aliases for UNC5C Gene

  • Unc-5 Netrin Receptor C 2 3 5
  • Unc5 (C.Elegans Homolog) C 2 3
  • Protein Unc-5 Homolog 3 3 4
  • Protein Unc-5 Homolog C 3 4
  • UNC5H3 3 4
  • Unc-5 Homolog C (C. Elegans) 2
  • Unc-5 Homolog 3 3
  • Unc-5 Homolog C 3

External Ids for UNC5C Gene

Previous GeneCards Identifiers for UNC5C Gene

  • GC04M096436
  • GC04M096548
  • GC04M096446
  • GC04M096308
  • GC04M096083
  • GC04M091820

Summaries for UNC5C Gene

Entrez Gene Summary for UNC5C Gene

  • This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

GeneCards Summary for UNC5C Gene

UNC5C (Unc-5 Netrin Receptor C) is a Protein Coding gene. Among its related pathways are Developmental Biology and Axon guidance. GO annotations related to this gene include netrin receptor activity. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for UNC5C Gene

  • Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Gene Wiki entry for UNC5C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5C Gene

Genomics for UNC5C Gene

Regulatory Elements for UNC5C Gene

Promoters for UNC5C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UNC5C on UCSC Golden Path with GeneCards custom track

Genomic Location for UNC5C Gene

Chromosome:
4
Start:
95,162,504 bp from pter
End:
95,549,210 bp from pter
Size:
386,707 bases
Orientation:
Minus strand

Genomic View for UNC5C Gene

Genes around UNC5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5C Gene

Proteins for UNC5C Gene

  • Protein details for UNC5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95185-UNC5C_HUMAN
    Recommended name:
    Netrin receptor UNC5C
    Protein Accession:
    O95185
    Secondary Accessions:
    • Q8IUT0

    Protein attributes for UNC5C Gene

    Size:
    931 amino acids
    Molecular mass:
    103146 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DCC. Interacts (tyrosine phosphorylated form) with PTPN11. Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (By similarity).
    Miscellaneous:
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

    Alternative splice isoforms for UNC5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5C Gene

Proteomics data for UNC5C Gene at MOPED

Post-translational modifications for UNC5C Gene

  • Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Glycosylation at Asn 236 and Asn 361
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC5C Gene

Antibody Products

No data available for DME Specific Peptides for UNC5C Gene

Domains & Families for UNC5C Gene

Gene Families for UNC5C Gene

Suggested Antigen Peptide Sequences for UNC5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95185

UniProtKB/Swiss-Prot:

UNC5C_HUMAN :
  • Contains 1 death domain.
  • Belongs to the unc-5 family.
Domain:
  • Contains 1 death domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 2 TSP type-1 domains.
  • Contains 1 ZU5 domain.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5C: view

Function for UNC5C Gene

Molecular function for UNC5C Gene

GENATLAS Biochemistry:
C elegans Unc5 and murine unc5hr homolog,involved in cell migration during cerebellum development,inducing repulsion in axon guidance through its cytoplasmic tail,expressed in brain,fetal heart
UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
genes like me logo Genes that share phenotypes with UNC5C: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC5C Gene

Localization for UNC5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5C Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5C Gene COMPARTMENTS Subcellular localization image for UNC5C gene
Compartment Confidence
plasma membrane 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with UNC5C: view

Pathways & Interactions for UNC5C Gene

genes like me logo Genes that share pathways with UNC5C: view

Pathways by source for UNC5C Gene

1 KEGG pathway for UNC5C Gene
2 Qiagen pathways for UNC5C Gene

SIGNOR curated interactions for UNC5C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0033564 anterior/posterior axon guidance IEA --
GO:0038007 netrin-activated signaling pathway IEA --
genes like me logo Genes that share ontologies with UNC5C: view

Drugs & Compounds for UNC5C Gene

No Compound Related Data Available

Transcripts for UNC5C Gene

mRNA/cDNA for UNC5C Gene

Unigene Clusters for UNC5C Gene

Unc-5 homolog C (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - -
SP2: -
SP3:

Relevant External Links for UNC5C Gene

GeneLoc Exon Structure for
UNC5C
ECgene alternative splicing isoforms for
UNC5C

Expression for UNC5C Gene

mRNA expression in normal human tissues for UNC5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC5C Gene

This gene is overexpressed in Adrenal (47.2) and Fetal Brain (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5C Gene



SOURCE GeneReport for Unigene cluster for UNC5C Gene Hs.388565

mRNA Expression by UniProt/SwissProt for UNC5C Gene

O95185-UNC5C_HUMAN
Tissue specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.
genes like me logo Genes that share expression patterns with UNC5C: view

Protein tissue co-expression partners for UNC5C Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UNC5C Gene

Orthologs for UNC5C Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC5C 36
  • 100 (a)
OneToOne
UNC5C 35
  • 99.5 (n)
  • 99.89 (a)
cow
(Bos Taurus)
Mammalia UNC5C 35
  • 91.43 (n)
  • 97.42 (a)
UNC5C 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC5C 36
  • 97 (a)
OneToOne
UNC5C 35
  • 91.69 (n)
  • 97.1 (a)
mouse
(Mus musculus)
Mammalia Unc5c 16
Unc5c 36
  • 97 (a)
OneToOne
Unc5c 35
  • 89.65 (n)
  • 97.1 (a)
oppossum
(Monodelphis domestica)
Mammalia UNC5C 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Unc5c 35
  • 88.97 (n)
  • 96.99 (a)
chicken
(Gallus gallus)
Aves UNC5C 35
  • 82.46 (n)
  • 92.7 (a)
UNC5C 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC5C 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5c 35
  • 77.62 (n)
  • 86.85 (a)
zebrafish
(Danio rerio)
Actinopterygii unc5c 36
  • 79 (a)
OneToMany
UNC5C (1 of 2) 36
  • 64 (a)
OneToMany
Dr.14572 35
unc5c 35
  • 72.35 (n)
  • 80 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009061 35
  • 45.47 (n)
  • 36.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta unc-5 35
  • 44.27 (n)
  • 34.13 (a)
unc-5 37
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-5 37
  • 28 (a)
Species with no ortholog for UNC5C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC5C Gene

ENSEMBL:
Gene Tree for UNC5C (if available)
TreeFam:
Gene Tree for UNC5C (if available)

Paralogs for UNC5C Gene

(4) SIMAP similar genes for UNC5C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UNC5C: view

Variants for UNC5C Gene

Sequence variations from dbSNP and Humsavar for UNC5C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_019731 -
rs2289043 - 95,185,171(-) ACAGA(C/T)GGGAG reference, missense
rs34585936 - 95,170,263(+) GAAAG(C/T)ACTGG reference, missense
rs265012 -- 95,491,734(+) TATGT(C/T)GTGTT intron-variant
rs265013 -- 95,490,366(+) ATTCA(A/C/G)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5C Gene

Variant ID Type Subtype PubMed ID
nsv830011 CNV Gain 17160897
esv1489767 CNV Insertion 17803354
esv1617018 CNV Insertion 17803354
esv1143724 CNV Insertion 17803354
nsv879623 CNV Loss 21882294
dgv5659n71 CNV Loss 21882294
nsv519986 CNV Loss 19592680
nsv822655 CNV Gain 20364138
esv2674923 CNV Deletion 23128226
nsv471768 CNV Loss 16327809
esv27157 CNV Loss 19812545
esv25475 CNV Loss 19812545
nsv879626 CNV Loss 21882294
nsv523039 CNV Loss 19592680
esv2577861 CNV Deletion 19546169
esv2727993 CNV Deletion 23290073
esv2041389 CNV Deletion 18987734
esv2808 CNV Deletion 18987735
esv2727994 CNV Deletion 23290073
esv1001867 CNV Deletion 20482838
esv1227332 CNV Deletion 17803354
esv2660811 CNV Deletion 23128226
nsv879627 CNV Gain 21882294
esv2727996 CNV Deletion 23290073
esv2661832 CNV Deletion 23128226
nsv521417 CNV Loss 19592680
nsv525953 CNV Loss 19592680
nsv527705 CNV Loss 19592680

Variation tolerance for UNC5C Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.02; 96.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC5C Gene

HapMap Linkage Disequilibrium report
UNC5C
Human Gene Mutation Database (HGMD)
UNC5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5C Gene

Disorders for UNC5C Gene

Relevant External Links for UNC5C

Genetic Association Database (GAD)
UNC5C
Human Genome Epidemiology (HuGE) Navigator
UNC5C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC5C

No disorders were found for UNC5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5C Gene

Publications for UNC5C Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K. … Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23 67
  2. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. (PMID: 9782087) Ackerman S.L. … Knowles B.B. (Genomics 1998) 2 3 23
  3. Changes in UNC5C gene methylation during human gastric carcinogenesis. (PMID: 20032384) Hibi K. … Sanada Y. (Anticancer Res. 2009) 3 23
  4. Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer. (PMID: 19331160) Hibi K. … Sanada Y. (Anticancer Res. 2009) 3 23
  5. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. (PMID: 18054557) Shin S.K. … Goel A. (Gastroenterology 2007) 3 23

Products for UNC5C Gene

Sources for UNC5C Gene

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