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UNC5C Gene

protein-coding   GIFtS: 65
GCID: GC04M096083

Unc-5 Homolog C (C. Elegans)

(Previous name: unc5 (C.elegans homolog) c)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-5 Homolog C (C. Elegans)1 2     Protein Unc-5 Homolog C2 3
UNC5H32 3 5     Netrin Receptor UNC5C2
Unc5 (C.Elegans Homolog) C1 2     Unc-5 Homolog 32
Protein Unc-5 Homolog 32 3     

External Ids:    HGNC: 125691   Entrez Gene: 86332   Ensembl: ENSG000001821687   OMIM: 6036105   UniProtKB: O951853   

Export aliases for UNC5C gene to outside databases

Previous GC identifers: GC04M096436 GC04M096548 GC04M096446 GC04M096308 GC04M091820


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UNC5C Gene:
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon
extension and cell migration during neural development. They are bifunctional proteins that act as attractants
for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two
classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are
transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the
extracellular region. (provided by RefSeq, Jul 2008)

GeneCards Summary for UNC5C Gene:
UNC5C (unc-5 homolog C (C. elegans)) is a protein-coding gene. GO annotations related to this gene include netrin receptor activity. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances
independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated
with netrin ligand (By similarity)

Gene Wiki entry for UNC5C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UNC5C gene promoter:
         c-Fos   TBP   AP-1   FosB   Lmo2   RORalpha1   POU2F1   TFIID   Zic1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC5C promoter sequence
   Search Chromatin IP Primers for UNC5C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNC5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21-q23   Ensembl cytogenetic band:  4q22.3   HGNC cytogenetic band: 4q21-q23

UNC5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5C gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M096083:  view genomic region     (about GC identifiers)

Start:
96,083,655 bp from pter      End:
96,470,361 bp from pter
Size:
386,707 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185 (See protein sequence)
Recommended Name: Netrin receptor UNC5C precursor  
Size: 931 amino acids; 103146 Da
Subunit: Interacts with the cytoplasmic part of DCC (By similarity)
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or
kidney cancers
Secondary accessions: Q8IUT0
Alternative splicing: 2 isoforms:  O95185-1   O95185-2   

Explore the universe of human proteins at neXtProt for UNC5C: NX_O95185

Explore proteomics data for UNC5C at MOPED

Post-translational modifications: 

  • Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with
    PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine
    phosphorylation is netrin-dependent (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is
    associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)1
  • Glycosylation2 at Asn236, Asn361
  • Modification sites at PhosphoSitePlus

  • See UNC5C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003719.3  
    ENSEMBL proteins: 
     ENSP00000406022   ENSP00000426924   ENSP00000426153   ENSP00000425117  
    Reactome Protein details: O95185

    UNC5C Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set
     IPR000906 ZU5

    Graphical View of Domain Structure for InterPro Entry O95185

    ProtoNet protein and cluster: O95185

    2 Blocks protein domains:
    IPB000488 Death domain
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 2 TSP type-1 domains
    Similarity: Contains 1 ZU5 domain


    Find genes that share domains with UNC5C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC5C_HUMAN, O95185
    Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
    developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
    with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances
    independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated
    with netrin ligand (By similarity)

         Genatlas biochemistry entry for UNC5C:
    C elegans Unc5 and murine unc5hr homolog,involved in cell migration during cerebellum development,inducing
    repulsion in axon guidance through its cytoplasmic tail,expressed in brain,fetal heart

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005042netrin receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with UNC5C           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for UNC5C:
     Decreased Wnt reporter activit  Decreased nuclei size in G2M 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Unc5c):
     behavior/neurological  cellular  growth/size/body  mortality/aging  nervous system 
     reproductive system 

    Find genes that share phenotypes with UNC5C           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UNC5C

    miRNA
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    miRTarBase miRNAs that target UNC5C:
    hsa-mir-335-5p (MIRT017932)

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    Selected qRT-PCR Assays for microRNAs that regulate UNC5C (see all 115):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-1245 hsa-miR-200a hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidUNC5C 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UNC5C_HUMAN, O95185: Membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UNC5C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UNC5C About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Netrin-1 signaling
    Netrin-1 signaling
    Netrin mediated repulsion signals0.00
    3Netrin Signaling
    Netrin Signaling
    4Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility
    5Axon guidance
    Axon guidance


    Find genes that share SuperPaths with UNC5C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UNC5C
        Guidance Cues and Growth Cone Motility
    Netrin Signaling


    1 Reactome Pathway for UNC5C
        Netrin mediated repulsion signals


    1 Kegg Pathway  (Kegg details for UNC5C):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNC5C
    Interactions:

        Search GeneGlobe Interaction Network for UNC5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for UNC5C (O951853 ENSP000004060224) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTN1O956313, ENSP000001732294I2D: score=1 STRING: ENSP00000173229
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    DAPK1P533553, ENSP000003507854I2D: score=1 STRING: ENSP00000350785
    DCCENSP000003891404STRING: ENSP00000389140
    FYNENSP000003576564STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction ----
    GO:0007411axon guidance TAS--
    GO:0007420brain development IEA--
    GO:0030334regulation of cell migration IEA--

    Find genes that share ontologies with UNC5C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNC5C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UNC5C gene: 
    NM_003728.3  

    Unigene Cluster for UNC5C:

    Unc-5 homolog C (C. elegans)
    Hs.388565  [show with all ESTs]
    Unigene Representative Sequence: NM_003728
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453304(uc003hto.3 uc010ilc.2) ENST00000513796 ENST00000506749(uc003htq.3)
    ENST00000504962
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UNC5C (see all 115):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-1245 hsa-miR-200a hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidUNC5C 3' UTR sequence
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    Additional mRNA sequence: 

    AF055634.1 AK022487.1 AK290500.1 AK308421.1 BC034747.1 BC041156.1 BX538341.1 

    6 DOTS entries:

    DT.311753  DT.40112526  DT.101976897  DT.404930  DT.308302  DT.95363749 

    16 AceView cDNA sequences:

    AI677642 BX280911 AW078867 NM_003728 AL119797 CD617402 AA348167 AI621080 
    BC041156 AF055634 AI917731 T09065 BE700724 AI187839 BF037457 BI769500 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5C    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                    -                             -                       -                                       
    SP2:                    -                                                                                             
    SP3:                                                                                                                  


    ECgene alternative splicing isoforms for UNC5C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UNC5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAAATGT
    UNC5C Expression
    About this image


    UNC5C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cushion Mesenchymal Cells Endocardium
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Bone (Muscoskeletal System)
             Mandibular Process
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    UNC5C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNC5C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388565

    UniProtKB/Swiss-Prot: UNC5C_HUMAN, O95185
    Tissue specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UNC5C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc5c1 , 5 unc-5 homolog C (C. elegans)1, 5 89.65(n)1
    97.1(a)1
      3 (65.57 cM)5
    222531  NM_009472.31  NP_033498.11 
     1414655645 
    chicken
    (Gallus gallus)
    Aves UNC5C1 unc-5 homolog C (C. elegans) 82.46(n)
    92.7(a)
      395101  NM_204451.1  NP_989782.1 
    lizard
    (Anolis carolinensis)
    Reptilia UNC5C6
    unc-5 homolog C (C. elegans)
    91(a)
    1 ↔ 1
    5(49445530-49820108)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia unc5c1 unc-5 homolog C (C. elegans) 77.62(n)
    86.85(a)
      100485730  XM_004911103.1  XP_004911160.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145722 Transcribed sequence with moderate similarity to protein refNP_003719.2 (H.sapiens) unc5 (C.elegans homolog) c; homolog of C. elegans transmembrane receptor Unc5 [Homo sapiens] less 79.49(n)    BI533575.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta unc-51 , 3 axon guidance netrin receptor3
    unc-51
    28(a)3
    44.27(n)1
    34.13(a)1
      367031  NM_137189.21  NP_611033.21 


    ENSEMBL Gene Tree for UNC5C (if available)
    TreeFam Gene Tree for UNC5C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UNC5C gene
    UNC5B2  BAI12  UNC5A2  UNC5CL2  CFP2  BAI32  BAI22  UNC5D2  
    4 SIMAP similar genes for UNC5C using alignment to 4 protein entries:     UNC5C_HUMAN (see all proteins):
    UNC5B    UNC5A    UNC5D    CFP

    Find genes that share paralogs with UNC5C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UNC5C (see all 7961)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719708211,2
    C--92140670(+) AAAGT-/ATAATAAT 1 -- int10--------
    rs1995180331,2
    C--92178896(+) TTTTT-/TCTTTTT 1 -- int10--------
    rs125103631,2
    C,H--96083364(+) TAACCG/ACTCAT 1 -- ds50017Minor allele frequency- A:0.01NS EA NA WA 628
    rs38572291,2
    C,H--96083403(-) gcctgA/Ggtctt 1 -- ds500113Minor allele frequency- G:0.19NA WA CSA EA 376
    rs772883591,2
    F--96083482(+) GGTGAT/CTCCAG 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1438653281,2
    --96083545(+) AGGAGA/GTTGTG 1 -- ds50010--------
    rs1154562471,2
    F--96083563(+) TCCACG/ACAGGA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1923995301,2
    --96083577(+) AAAGCC/TTTTCT 1 -- ds50010--------
    rs1822284801,2
    --96083913(+) GCATAA/GAAGAT 1 -- ut310--------
    rs1403265111,2
    C--96083965(+) CGGAAA/TAGCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UNC5C (96083655 - 96333655 bp, first 250kb of UNC5C)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UNC5C (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2577861CNV Deletion19546169
    esv2661832CNV Deletion23128226
    esv2808CNV Deletion18987735
    esv2674923CNV Deletion23128226
    esv2727996CNV Deletion23290073
    esv2727994CNV Deletion23290073
    esv1227332CNV Deletion17803354
    esv2660811CNV Deletion23128226
    esv2041389CNV Deletion18987734
    esv2727993CNV Deletion23290073

    Human Gene Mutation Database (HGMD): UNC5C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC5C
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC5C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603610    OMIM disorders: --


    Find genes that share disorders with UNC5C           About GenesLikeMe

    Genetic Association Database (GAD): UNC5C
    Human Genome Epidemiology (HuGE) Navigator: UNC5C (7 documents)

    Export disorders for UNC5C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UNC5C gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with UNC5C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. (PubMed id 9782087)1, 2, 3, 9 Ackerman S.L. and Knowles B.B. (Genomics 1998)
    2. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 9 Thiebault K.... Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (Biol. Psychiatry 2010)
    5. Genome-wide association reveals genetic effects on human AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PubMed id 20932310)1, 4 Han M.R....Wang L.S. (BMC Neurol 2010)
    6. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    7. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. (PubMed id 19475631)1, 4 Evangelou E....Ioannidis J.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer. (PubMed id 19331160)1, 9 Hibi K....Sanada Y. (Anticancer Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8633 HGNC: 12569 AceView: UNC5C Ensembl:ENSG00000182168 euGenes: HUgn8633
    ECgene: UNC5C Kegg: 8633 H-InvDB: UNC5C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UNC5C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UNC5C gene:
    Search GeneIP for patents involving UNC5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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