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Aliases for UNC5C Gene

Aliases for UNC5C Gene

  • Unc-5 Netrin Receptor C 2 3 5
  • Unc5 (C.Elegans Homolog) C 2 3
  • Protein Unc-5 Homolog 3 3 4
  • Protein Unc-5 Homolog C 3 4
  • UNC5H3 3 4
  • Unc-5 Homolog C (C. Elegans) 2
  • Netrin Receptor UNC5C 3
  • Unc-5 Homolog 3 3
  • Unc-5 Homolog C 3

External Ids for UNC5C Gene

Previous GeneCards Identifiers for UNC5C Gene

  • GC04M096436
  • GC04M096548
  • GC04M096446
  • GC04M096308
  • GC04M096083
  • GC04M091820

Summaries for UNC5C Gene

Entrez Gene Summary for UNC5C Gene

  • This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

GeneCards Summary for UNC5C Gene

UNC5C (Unc-5 Netrin Receptor C) is a Protein Coding gene. Diseases associated with UNC5C include Hereditary Colorectal Cancer. Among its related pathways are Netrin-1 signaling and Netrin Signaling. GO annotations related to this gene include netrin receptor activity. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot for UNC5C Gene

  • Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Gene Wiki entry for UNC5C Gene

Additional gene information for UNC5C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5C Gene

Genomics for UNC5C Gene

Regulatory Elements for UNC5C Gene

Enhancers for UNC5C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H095290 0.6 dbSUPER 5.8 +258.1 258079 1.7 IKZF1 ELF1 EBF1 RUNX3 IKZF2 EZH2 ZNF592 UNC5C GC04M095360 GC04P095189 PIR50489
GH04H095395 0.4 dbSUPER 6.7 +152.9 152855 1.9 REST UNC5C GC04M095360 GC04P095538
GH04H095401 0.4 dbSUPER 6.6 +146.7 146651 2 MAFK UNC5C GC04M095360 GC04P095538
GH04H095262 0.4 dbSUPER 5.3 +285.0 285001 2.5 ZBTB20 UNC5C GC04P095189 PIR50489 GC04M095360
GH04H095411 0.6 FANTOM5 dbSUPER 3.3 +137.3 137297 0.2 UNC5C GC04M095360 GC04P095538
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UNC5C on UCSC Golden Path with GeneCards custom track

Promoters for UNC5C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000170905 409 2800 PKNOX1 TBL1XR1 ZSCAN4 KLF17 FEZF1 BATF ZNF2 GLIS2 ZNF366 ZNF143

Genomic Locations for UNC5C Gene

Genomic Locations for UNC5C Gene
386,707 bases
Minus strand

Genomic View for UNC5C Gene

Genes around UNC5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5C Gene

Proteins for UNC5C Gene

  • Protein details for UNC5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Netrin receptor UNC5C
    Protein Accession:
    Secondary Accessions:
    • Q8IUT0

    Protein attributes for UNC5C Gene

    931 amino acids
    Molecular mass:
    103146 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DCC. Interacts (tyrosine phosphorylated form) with PTPN11. Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (By similarity).
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

    Alternative splice isoforms for UNC5C Gene


neXtProt entry for UNC5C Gene

Post-translational modifications for UNC5C Gene

  • Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Glycosylation at Asn236 and posLast=361361
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UNC5C Gene

Domains & Families for UNC5C Gene

Gene Families for UNC5C Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for UNC5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the unc-5 family.
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5C: view

Function for UNC5C Gene

Molecular function for UNC5C Gene

GENATLAS Biochemistry:
C elegans Unc5 and murine unc5hr homolog,involved in cell migration during cerebellum development,inducing repulsion in axon guidance through its cytoplasmic tail,expressed in brain,fetal heart
UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Phenotypes From GWAS Catalog for UNC5C Gene

Gene Ontology (GO) - Molecular Function for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005042 netrin receptor activity IEA --
genes like me logo Genes that share ontologies with UNC5C: view
genes like me logo Genes that share phenotypes with UNC5C: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC5C Gene

Localization for UNC5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5C Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC5C gene
Compartment Confidence
plasma membrane 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with UNC5C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UNC5C Gene

Pathways & Interactions for UNC5C Gene

genes like me logo Genes that share pathways with UNC5C: view

Pathways by source for UNC5C Gene

1 KEGG pathway for UNC5C Gene
2 Qiagen pathways for UNC5C Gene

SIGNOR curated interactions for UNC5C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance TAS 9126742
GO:0007420 brain development TAS,IEA --
genes like me logo Genes that share ontologies with UNC5C: view

Drugs & Compounds for UNC5C Gene

No Compound Related Data Available

Transcripts for UNC5C Gene

Unigene Clusters for UNC5C Gene

Unc-5 homolog C (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - -
SP2: -

Relevant External Links for UNC5C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNC5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNC5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC5C Gene

This gene is overexpressed in Adrenal (47.2) and Fetal Brain (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5C Gene

Protein tissue co-expression partners for UNC5C Gene

NURSA nuclear receptor signaling pathways regulating expression of UNC5C Gene:


SOURCE GeneReport for Unigene cluster for UNC5C Gene:


mRNA Expression by UniProt/SwissProt for UNC5C Gene:

Tissue specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.

Evidence on tissue expression from TISSUES for UNC5C Gene

  • Nervous system(4.8)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with UNC5C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC5C Gene

Orthologs for UNC5C Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UNC5C 33 34
  • 99.5 (n)
(Monodelphis domestica)
Mammalia UNC5C 34
  • 95 (a)
(Canis familiaris)
Mammalia UNC5C 33 34
  • 91.69 (n)
(Bos Taurus)
Mammalia UNC5C 33 34
  • 91.43 (n)
(Mus musculus)
Mammalia Unc5c 33 16 34
  • 89.65 (n)
(Rattus norvegicus)
Mammalia Unc5c 33
  • 88.97 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
-- 34
  • 88 (a)
(Gallus gallus)
Aves UNC5C 33 34
  • 82.46 (n)
(Anolis carolinensis)
Reptilia UNC5C 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5c 33
  • 77.62 (n)
(Danio rerio)
Actinopterygii unc5c 33 34
  • 72.35 (n)
UNC5C (1 of 2) 34
  • 64 (a)
Dr.14572 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009061 33
  • 45.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta unc-5 35 33
  • 44.27 (n)
(Caenorhabditis elegans)
Secernentea unc-5 35
  • 28 (a)
Species where no ortholog for UNC5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC5C Gene

Gene Tree for UNC5C (if available)
Gene Tree for UNC5C (if available)

Paralogs for UNC5C Gene

Paralogs for UNC5C Gene

(4) SIMAP similar genes for UNC5C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UNC5C: view

Variants for UNC5C Gene

Sequence variations from dbSNP and Humsavar for UNC5C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000013222 -- 95,461,268(+) TTCCC(A/G)TGAAG intron-variant
rs1000016193 -- 95,405,261(+) GCTGG(A/G)GCCCA intron-variant
rs1000023589 -- 95,183,988(+) ATATT(A/G)TCATT intron-variant
rs10000289 -- 95,516,455(+) TCCAA(A/T)TTTTG intron-variant
rs1000032038 -- 95,370,177(+) ATTTC(A/G)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5C Gene

Variant ID Type Subtype PubMed ID
nsv964075 CNV duplication 23825009
nsv830011 CNV gain 17160897
nsv822655 CNV gain 20364138
nsv594907 CNV gain 21841781
nsv527705 CNV loss 19592680
nsv525953 CNV loss 19592680
nsv523039 CNV loss 19592680
nsv521417 CNV loss 19592680
nsv519986 CNV loss 19592680
nsv478904 CNV novel sequence insertion 20440878
nsv471768 CNV loss 16327809
nsv1151405 CNV deletion 26484159
nsv1133345 CNV tandem duplication 24896259
nsv1074200 CNV deletion 25765185
nsv1005881 CNV gain 25217958
esv3601466 CNV loss 21293372
esv3601464 CNV loss 21293372
esv3569614 CNV loss 25503493
esv3569613 CNV loss 25503493
esv3564289 CNV deletion 23714750
esv3564288 CNV deletion 23714750
esv3564287 CNV deletion 23714750
esv3450367 CNV duplication 20981092
esv2808 CNV loss 18987735
esv2763844 CNV loss 21179565
esv2727996 CNV deletion 23290073
esv2727994 CNV deletion 23290073
esv2727993 CNV deletion 23290073
esv27157 CNV loss 19812545
esv2674923 CNV deletion 23128226
esv2661832 CNV deletion 23128226
esv2660811 CNV deletion 23128226
esv2577861 CNV deletion 19546169
esv25475 CNV loss 19812545
esv2041389 CNV deletion 18987734
esv1617018 CNV insertion 17803354
esv1489767 CNV insertion 17803354
esv1227332 CNV deletion 17803354
esv1143724 CNV insertion 17803354
esv1001867 CNV deletion 20482838
dgv9176n54 CNV loss 21841781
dgv9175n54 CNV loss 21841781
dgv2856n106 CNV deletion 24896259

Variation tolerance for UNC5C Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.02; 96.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC5C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5C Gene

Disorders for UNC5C Gene

MalaCards: The human disease database

(1) MalaCards diseases for UNC5C Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
hereditary colorectal cancer
- elite association - COSMIC cancer census association via MalaCards
Search UNC5C in MalaCards View complete list of genes associated with diseases

Relevant External Links for UNC5C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UNC5C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UNC5C Gene

Publications for UNC5C Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K … Mehlen P (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22 60
  2. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. (PMID: 9782087) Ackerman SL … Knowles BB (Genomics 1998) 2 3 4 22 60
  3. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. (PMID: 19475631) Evangelou E … Genetic Epidemiology of Parkinson's Disease (GEOPD) Consortium (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 45 60
  4. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M … Iwata N (Biological psychiatry 2010) 3 45 60
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 45 60

Products for UNC5C Gene

Sources for UNC5C Gene

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