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Aliases for UNC5B Gene

Aliases for UNC5B Gene

  • Unc-5 Netrin Receptor B 2 3 5
  • P53-Regulated Receptor For Death And Life Protein 1 3 4
  • Protein Unc-5 Homolog 2 3 4
  • Protein Unc-5 Homolog B 3 4
  • P53RDL1 3 4
  • UNC5H2 3 4
  • Transmembrane Receptor Unc5H2 3
  • Unc-5 Homolog B (C. Elegans) 2
  • Unc5 (C.Elegans Homolog) B 2
  • Netrin Receptor UNC5B 3
  • Unc-5 Homolog 2 3
  • Unc-5 Homolog B 3

External Ids for UNC5B Gene

Previous GeneCards Identifiers for UNC5B Gene

  • GC00U990539
  • GC10P072864
  • GC10P072316
  • GC10P072642
  • GC10P072972
  • GC10P066966

Summaries for UNC5B Gene

Entrez Gene Summary for UNC5B Gene

  • This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for UNC5B Gene

UNC5B (Unc-5 Netrin Receptor B) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Guidance Cues and Growth Cone Motility. An important paralog of this gene is UNC5C.

UniProtKB/Swiss-Prot for UNC5B Gene

  • Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5B Gene

Genomics for UNC5B Gene

Regulatory Elements for UNC5B Gene

Enhancers for UNC5B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F071231 1.1 FANTOM5 Ensembl ENCODE 37.8 +22.1 22095 5.5 PKNOX1 SIN3A FEZF1 ZNF121 GLIS2 KLF7 ZNF263 ZNF610 PBX2 GLIS1 UNC5B UNC5B-AS1 PCBD1 SLC29A3 C10orf105 PIR59347
GH10F071239 1 Ensembl ENCODE 29.6 +32.3 32318 10.1 HDAC1 PKNOX1 SIN3A KLF17 RAD21 GATA2 ZNF366 SCRT2 RCOR1 FOS UNC5B UNC5B-AS1 PCBD1 PIR59347 PIR34735
GH10F071251 1.1 Ensembl ENCODE 24.6 +41.8 41839 5.6 KLF1 ESRRA PKNOX1 ZMYM3 RAD21 ZNF664 POLR2A SCRT2 SMC3 FOS UNC5B UNC5B-AS1 PCBD1 CDH23 PIR34735 PIR59347
GH10F071259 1 Ensembl ENCODE 23.6 +49.6 49603 5.5 RAD21 ZNF121 GLIS2 FOS EGR2 SMARCA5 NFIL3 ZNF341 CEBPA MYC UNC5B UNC5B-AS1 CDH23 PIR34735 PIR59347
GH10F071265 1.2 FANTOM5 Ensembl ENCODE 13.4 +56.6 56583 7.8 PKNOX1 CREB3L1 FEZF1 ZNF2 ZNF143 FOS ZNF548 KLF13 ZNF263 SP3 UNC5B UNC5B-AS1 SLC29A3 CDH23-AS1 CDH23 PCBD1 PIR34735 PIR59347
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UNC5B on UCSC Golden Path with GeneCards custom track

Promoters for UNC5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001424602 665 2401 CREB3L1 SIN3A FEZF1 ZNF48 ZNF2 ZNF121 GLIS2 ZNF263 SP3 REST

Genomic Location for UNC5B Gene

Chromosome:
10
Start:
71,212,535 bp from pter
End:
71,302,879 bp from pter
Size:
90,345 bases
Orientation:
Plus strand

Genomic View for UNC5B Gene

Genes around UNC5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5B Gene

Proteins for UNC5B Gene

  • Protein details for UNC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZJ1-UNC5B_HUMAN
    Recommended name:
    Netrin receptor UNC5B
    Protein Accession:
    Q8IZJ1
    Secondary Accessions:
    • Q5T3R9
    • Q5T3S0
    • Q86SN3
    • Q8N1Y2
    • Q9H9F3

    Protein attributes for UNC5B Gene

    Size:
    945 amino acids
    Molecular mass:
    103638 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part (PubMed:12359238). Interacts (via death domain) with DAPK1 (via death domain) (PubMed:15729359, PubMed:18582460). Interacts (via extracellular domain) with FLRT3 (via extracellular domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with FLRT2 and FLRT3 (via extracellular domain), but has higher affinity for FLRT3 (PubMed:25374360). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (PubMed:26235030).
    Miscellaneous:
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.
    SequenceCaution:
    • Sequence=BAB14276.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04382.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UNC5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5B Gene

Post-translational modifications for UNC5B Gene

  • Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
  • Phosphorylated on cytoplasmic tyrosine residues.
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Glycosylation at Asn 222 and Asn 347
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC5B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UNC5B (UNC5B)
  • Abcam antibodies for UNC5B
  • Santa Cruz Biotechnology (SCBT) Antibodies for UNC5B

No data available for DME Specific Peptides for UNC5B Gene

Domains & Families for UNC5B Gene

Gene Families for UNC5B Gene

Suggested Antigen Peptide Sequences for UNC5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZJ1

UniProtKB/Swiss-Prot:

UNC5B_HUMAN :
  • Contains 1 death domain.
  • Belongs to the unc-5 family.
Domain:
  • Contains 1 death domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 2 TSP type-1 domains.
  • Contains 1 ZU5 domain.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5B: view

Function for UNC5B Gene

Molecular function for UNC5B Gene

UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Gene Ontology (GO) - Molecular Function for UNC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18469807
genes like me logo Genes that share ontologies with UNC5B: view
genes like me logo Genes that share phenotypes with UNC5B: view

Animal Models for UNC5B Gene

MGI Knock Outs for UNC5B:

Animal Model Products

  • Taconic Biosciences Mouse Models for UNC5B

miRNA for UNC5B Gene

miRTarBase miRNAs that target UNC5B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC5B Gene

Localization for UNC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5B Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=Associated with lipid rafts. {ECO:0000250 UniProtKB:O08722}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5B Gene COMPARTMENTS Subcellular localization image for UNC5B gene
Compartment Confidence
plasma membrane 4
extracellular 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UNC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with UNC5B: view

Pathways & Interactions for UNC5B Gene

genes like me logo Genes that share pathways with UNC5B: view

Pathways by source for UNC5B Gene

Gene Ontology (GO) - Biological Process for UNC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 18469807
genes like me logo Genes that share ontologies with UNC5B: view

No data available for SIGNOR curated interactions for UNC5B Gene

Transcripts for UNC5B Gene

Unigene Clusters for UNC5B Gene

Unc-5 homolog B (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - - -
SP3:
SP4:

Relevant External Links for UNC5B Gene

GeneLoc Exon Structure for
UNC5B
ECgene alternative splicing isoforms for
UNC5B

Expression for UNC5B Gene

mRNA expression in normal human tissues for UNC5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC5B Gene

This gene is overexpressed in Serum (41.6), Rectum (13.4), and Retina (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5B Gene



NURSA nuclear receptor signaling pathways regulating expression of UNC5B Gene:

UNC5B

SOURCE GeneReport for Unigene cluster for UNC5B Gene:

Hs.522997

mRNA Expression by UniProt/SwissProt for UNC5B Gene:

Q8IZJ1-UNC5B_HUMAN
Tissue specificity: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
genes like me logo Genes that share expression patterns with UNC5B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for UNC5B Gene

Orthologs for UNC5B Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC5B 34 35
  • 97.43 (n)
dog
(Canis familiaris)
Mammalia UNC5B 34 35
  • 91.36 (n)
cow
(Bos Taurus)
Mammalia UNC5B 34 35
  • 91.29 (n)
mouse
(Mus musculus)
Mammalia Unc5b 34 16 35
  • 87.44 (n)
rat
(Rattus norvegicus)
Mammalia Unc5b 34
  • 87.2 (n)
oppossum
(Monodelphis domestica)
Mammalia UNC5B 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC5B 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC5B 34 35
  • 80.96 (n)
lizard
(Anolis carolinensis)
Reptilia UNC5B 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5b 34
  • 71.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398393 34
zebrafish
(Danio rerio)
Actinopterygii unc5b 34 35
  • 68.57 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-5 34
  • 40.63 (n)
Species where no ortholog for UNC5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC5B Gene

ENSEMBL:
Gene Tree for UNC5B (if available)
TreeFam:
Gene Tree for UNC5B (if available)

Paralogs for UNC5B Gene

Paralogs for UNC5B Gene

(3) SIMAP similar genes for UNC5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNC5B: view

Variants for UNC5B Gene

Sequence variations from dbSNP and Humsavar for UNC5B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10450286 -- 71,226,735(+) TCGCT(A/G)ATATT intron-variant
rs10450287 -- 71,226,900(+) tatat(A/G)tacca intron-variant
rs10450288 -- 71,227,021(+) gctct(G/T)ttgcc intron-variant
rs10450303 -- 71,227,038(+) ggagt(G/T)caatg intron-variant
rs10450304 -- 71,227,154(+) taatt(G/T)ttgta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5B Gene

Variant ID Type Subtype PubMed ID
esv2738251 CNV deletion 23290073
esv2738262 CNV deletion 23290073
esv2738273 CNV deletion 23290073
esv3305960 CNV mobile element insertion 20981092
esv3434392 CNV duplication 20981092
esv3441106 CNV insertion 20981092
nsv1041665 CNV gain 25217958
nsv1044971 CNV gain 25217958
nsv25434 CNV deletion 16902084
nsv467371 CNV gain 19166990
nsv528622 CNV loss 19592680
nsv551500 CNV gain 21841781

Variation tolerance for UNC5B Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5B Gene

Disorders for UNC5B Gene

Relevant External Links for UNC5B

Genetic Association Database (GAD)
UNC5B
Human Genome Epidemiology (HuGE) Navigator
UNC5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC5B

No disorders were found for UNC5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5B Gene

Publications for UNC5B Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K. … Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 22 64
  2. Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion. (PMID: 26235030) Lu Y.C. … Arac D. (Structure 2015) 3 4 64
  3. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. (PMID: 20693423) Tadagavadi R.K. … Ramesh G. (J. Immunol. 2010) 2 3 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. [Correlation of netrin-1 expression with invasion of extra villous trophoblasts]. (PMID: 19570425) Yang Y. … Zou L. (Zhonghua Fu Chan Ke Za Zhi 2009) 3 22 64

Products for UNC5B Gene

Sources for UNC5B Gene

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