Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC5B Gene

protein-coding   GIFtS: 61
GCID: GC10P072972

Unc-5 Homolog B (C. Elegans)

(Previous name: unc5 (C.elegans homolog) b)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Unc-5 Homolog B (C. Elegans)1 2     Netrin Receptor UNC5B2
UNC5H22 3 5     p53RDL12
Protein Unc-5 Homolog 22 3     Transmembrane Receptor Unc5H22
Protein Unc-5 Homolog B2 3     Unc-5 Homolog 22
P53-Regulated Receptor For Death And Life Protein 12 3     P53RDL13
Unc5 (C.Elegans Homolog) B1     

External Ids:    HGNC: 125681   Entrez Gene: 2196992   Ensembl: ENSG000001077317   OMIM: 6078705   UniProtKB: Q8IZJ13   

Export aliases for UNC5B gene to outside databases

Previous GC identifers: GC00U990539 GC10P072864 GC10P072316 GC10P072642 GC10P066966


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UNC5B Gene:
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive
effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called
dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in
embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for
this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for UNC5B Gene: 
UNC5B (unc-5 homolog B (C. elegans)) is a protein-coding gene. Diseases associated with UNC5B include kidney cancer, and osteoarthritis, and among its related super-pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Axon guidance. GO annotations related to this gene include protein binding. An important paralog of this gene is BAI1.

UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1,
activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic
activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC5B gene promoter:
         MZF-1   POU2F1   p53   POU2F1a   MIF-1   POU6F1 (c2)   Nkx2-5   Tal-1beta   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC5B promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.2

UNC5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P072972:  view genomic region     (about GC identifiers)

Start:
72,972,298 bp from pter      End:
73,062,621 bp from pter
Size:
90,324 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1 (See protein sequence)
Recommended Name: Netrin receptor UNC5B precursor  
Size: 945 amino acids; 103638 Da
Subunit: Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic
part. Interacts (via death domain) with DAPK1 (via death domain)
Subcellular location: Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or
kidney cancers
Sequence caution: Sequence=BAB14276.1; Type=Erroneous initiation; Sequence=BAC04382.1; Type=Erroneous initiation;
Secondary accessions: Q5T3R9 Q5T3S0 Q86SN3 Q8N1Y2 Q9H9F3
Alternative splicing: 2 isoforms:  Q8IZJ1-1   Q8IZJ1-2   

Explore the universe of human proteins at neXtProt for UNC5B: NX_Q8IZJ1

Explore proteomics data for UNC5B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on cytoplasmic tyrosine residues (By similarity)
  • UniProtKB: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is
    associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis
  • UniProtKB: Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZJ1

  • UNC5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UNC5B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231818.1  NP_734465.2  

    ENSEMBL proteins: 
     ENSP00000334329   ENSP00000362288  
    Reactome Protein details: Q8IZJ1
    Human Recombinant Protein Products for UNC5B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for UNC5B
    OriGene Purified Protein for UNC5B
    OriGene Protein Over-expression Lysate for UNC5B
    OriGene MassSpec for UNC5B 
    OriGene Custom Protein Services for UNC5B
    GenScript Custom Purified and Recombinant Proteins Services for UNC5B
    Novus Biologicals UNC5B Proteins
    Sino Biological Recombinant Protein for UNC5B
    Sino Biological Cell Lysate for UNC5B 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UNC5B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    UNC5B for ontologies           About GeneDecksing



    UNC5B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of UNC5B
    R&D Systems Antibodies for UNC5B (UNC5H2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UNC5B
    GenScript Custom Superior Antibodies Services for UNC5B
    Novus Biologicals UNC5B Antibodies
    Abcam antibodies for UNC5B
    Cloud-Clone Corp. Antibodies for UNC5B 
    Search ThermoFisher Antibodies for UNC5B
    LSBio Antibodies in human, mouse, rat for UNC5B 

    Assay Products for UNC5B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UNC5B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UNC5B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UNC5B 
    Cloud-Clone Corp. CLIAs for UNC5B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    5/8 InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR007110 Ig-like_dom
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q8IZJ1

    ProtoNet protein and cluster: Q8IZJ1

    4 Blocks protein domains:
    IPB000488 Death domain
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 2 TSP type-1 domains
    Similarity: Contains 1 ZU5 domain


    UNC5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC5B_HUMAN, Q8IZJ1
    Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
    developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
    with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
    induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1,
    activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic
    activity
    Induction: By p53/TP53

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18469807
         
    UNC5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UNC5B:
     Increased cell number in G1, a 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Unc5b):
     cardiovascular system  cellular  embryogenesis  hearing/vestibular/ear  mortality/aging 
     nervous system 

    UNC5B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Unc5btm1.1Dyl for UNC5B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UNC5B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UNC5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UNC5B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UNC5B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5B
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5B (see all 33):
    hsa-miR-579 hsa-miR-3685 hsa-miR-15a hsa-miR-765 hsa-miR-424 hsa-miR-629 hsa-miR-15b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidUNC5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UNC5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UNC5B
    Sirion Biotech Customized adenovirus for overexpression of UNC5B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UNC5B (see all 8)
    OriGene ORF clones in mouse, rat for UNC5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNC5B (NM_170744)
    Sino Biological Human cDNA Clone for UNC5B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5B
    Sirion Biotech Customized lentivirus for stable overexpression of UNC5B 
                         Customized lentivirus expression plasmids for stable overexpression of UNC5B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UNC5B
    Search LifeMap BioReagents cell lines for UNC5B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UNC5B About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Apoptosis0.39
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Netrin-1 signaling
    Netrin-1 signaling0.33
    4Role of DCC in regulating apoptosis
    Role of DCC in regulating apoptosis
    5Netrin mediated repulsion signals
    Netrin mediated repulsion signals

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UNC5B
        Guidance Cues and Growth Cone Motility
    Netrin Signaling


    5/7        Reactome Pathways for UNC5B (see all 7)
        Netrin mediated repulsion signals
    Regulation of Apoptosis
    Developmental Biology
    Netrin-1 signaling
    Role of DCC in regulating apoptosis


    1         Kegg Pathway  (Kegg details for UNC5B):
        Axon guidance


    UNC5B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for UNC5B (Q8IZJ11, 3 ENSP000003343294) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAPK1P533553, ENSP000003507854I2D: score=3 STRING: ENSP00000350785
    AGAP2ENSP000003281604STRING: ENSP00000328160
    DCCENSP000003891404STRING: ENSP00000389140
    FYNENSP000003576564STRING: ENSP00000357656
    PIK3CAENSP000002639674STRING: ENSP00000263967
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance TAS--
    GO:0033564anterior/posterior axon guidance IEA--
    GO:0042981regulation of apoptotic process TAS--

    UNC5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC5B

    Search CenterWatch for drugs/clinical trials and news about UNC5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UNC5B gene (2 alternative transcripts): 
    NM_001244889.1  NM_170744.4  

    Unigene Cluster for UNC5B:

    Unc-5 homolog B (C. elegans)
    Hs.522997  [show with all ESTs]
    Unigene Representative Sequence: NM_170744
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335350(uc001jro.3 uc001jrp.3) ENST00000373192

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5B
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5B (see all 33):
    hsa-miR-579 hsa-miR-3685 hsa-miR-15a hsa-miR-765 hsa-miR-424 hsa-miR-629 hsa-miR-15b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidUNC5B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UNC5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5B
    Clone
    Products:
         
    OriGene clones in human, mouse for UNC5B (see all 8)
    OriGene ORF clones in mouse, rat for UNC5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNC5B (NM_170744)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5B
    Sirion Biotech Customized lentivirus for stable overexpression of UNC5B 
                         Customized lentivirus expression plasmids for stable overexpression of UNC5B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UNC5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UNC5B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5B

    Additional mRNA sequence: 

    AB096256.1 AK022859.1 AK094595.1 AK128132.1 AL049370.1 AY358351.1 

    6 DOTS entries:

    DT.91908160  DT.100774251  DT.75129932  DT.121221609  DT.121221632  DT.97843475 

    24/158 AceView cDNA sequences (see all 158):

    BQ638420 F05244 BQ182589 BM696085 CB306604 AW135129 AW054966 AA911800 
    AA873508 AA953288 BQ447630 CR617227 AU154333 AA897641 BM717683 AK128132 
    AA330282 AK094595 CA439546 BM987430 AI344433 CB529414 CR623022 AA425121 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
    SP1:        -     -                                                                                   -                                 
    SP2:        -     -                                               -                                   -                                 
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for UNC5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC5B expression in normal human tissues (normalized intensities)      UNC5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTTAGTT
    UNC5B Expression
    About this image


    UNC5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Tip Cells Arteries
     
     Fibroblast
             Human Dermal Fibroblasts-neonate (HDF-n)   
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Smooth Muscle (Muscoskeletal System)
             Human Bronchial Smooth Muscle Cells (HBSM)   

    See UNC5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC5B

    SOURCE GeneReport for Unigene cluster: Hs.522997

    UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1
    Tissue specificity: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney
    and hematopoietic and immune tissues

        SABiosciences Custom PCR Arrays for UNC5B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UNC5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UNC5B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UNC5B gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc5b1 , 5 unc-5 homolog B (C. elegans)1, 5 87.44(n)1
    92.38(a)1
      10 (31.52 cM)5
    1074491  NM_029770.21  NP_084046.21 
     607626105 
    chicken
    (Gallus gallus)
    Aves UNC5B1 unc-5 homolog B (C. elegans) 80.84(n)
    84.18(a)
      423716  NM_001031225.1  NP_001026396.1 
    lizard
    (Anolis carolinensis)
    Reptilia UNC5B6
    unc-5 homolog B (C. elegans)
    81(a)
    1 ↔ 1
    3(47541495-47842610)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983932 UNC-5 receptor 76.71(n)    AY099459.1 
    zebrafish
    (Danio rerio)
    Actinopterygii unc5b1 unc-5 homolog B (C. elegans) 67.91(n)
    69.58(a)
      494130  NM_001111149.1  NP_001104619.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta unc-56
    unc-5
    25(a)
    1 → many
    2R(11237659-11255807)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-51 Protein UNC-5 41.14(n)
    32.89(a)
      177334  NM_068422.4  NP_500823.1 


    ENSEMBL Gene Tree for UNC5B (if available)
    TreeFam Gene Tree for UNC5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC5B gene
    BAI12  UNC5CL2  UNC5C2  CFP2  BAI32  BAI22  UNC5A2  UNC5D2  
    3 SIMAP similar genes for UNC5B using alignment to 1 protein entry:     UNC5B_HUMAN:
    UNC5C    UNC5A    UNC5D

    UNC5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2141 SNPs in UNC5B are shown (see all 2141)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131459461,2
    C,F--72970338(+) TGGGGA/GGAGAG 2 -- us2k12Minor allele frequency- G:0.10CSA WA 119
    rs1838232361,2
    --72970352(+) GAACAC/TGCTGT 2 -- us2k10--------
    rs1130803031,2
    C,F--72970376(+) TGCCCG/ATCTCT 2 -- us2k12Minor allele frequency- A:0.10CSA WA 119
    rs1888418451,2
    --72970420(+) ACAACC/TTTGAC 2 -- us2k10--------
    rs1921061871,2
    --72970873(+) CTCAAC/TTGATG 2 -- us2k10--------
    rs728084481,2
    C,F--72971030(+) TGTGGA/GGAGGG 2 -- us2k12Minor allele frequency- G:0.04NA EA 240
    rs1152308951,2
    C,F--72971031(+) GTGGAG/AAGGGT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1146209291,2
    C,F--72971089(+) CCCTTC/TGCACA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1151771301,2
    F--72971090(+) CCTTCG/ACACAG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1418811851,2
    --72971125(+) TTCAAA/GTGAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC5B (72972298 - 73062621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for UNC5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738262CNV Deletion23290073
    esv2738273CNV Deletion23290073
    esv2738251CNV Deletion23290073
    esv270237CNV Insertion20981092
    nsv25434CNV Loss16902084
    nsv528622CNV Loss19592680
    nsv895712CNV Loss21882294
    nsv895713CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC5B
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607870    OMIM disorders: --

    8 diseases for UNC5B:    About MalaCards
    kidney cancer    osteoarthritis    rheumatoid arthritis    arthritis
    retinitis    alzheimer's disease    hypoxia    neuronitis


    UNC5B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for UNC5B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 3 12655055 (2), 18582460 (1)

    Genetic Association Database (GAD): UNC5B
    Human Genome Epidemiology (HuGE) Navigator: UNC5B (2 documents)

    Export disorders for UNC5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC5B gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with UNC5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 9 Thiebault K.... Mehlen P. (2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (2008)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. (PubMed id 15729359)1, 2 Llambi F....Mehlen P. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. p53RDL1 regulates of p53-dependent apoptosis. (PubMed id 12598906)1, 2 Tanikawa C.... Arakawa H. (2003)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)1, 2 Komatsuzaki K.... Kinane T.B. (2002)
    10. Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H. (PubMed id 18582460)2, 9 Maisse C....Hueber A.O. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219699 HGNC: 12568 AceView: UNC5B Ensembl:ENSG00000107731 euGenes: HUgn219699
    ECgene: UNC5B Kegg: 219699 H-InvDB: UNC5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UNC5B gene:
    Search GeneIP for patents involving UNC5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of UNC5B
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for UNC5B (UNC5H2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UNC5B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UNC5B  
     OriGene MassSpec something-or-other for UNC5B   OriGene clones in human, mouse for UNC5B  
     OriGene qSTAR qPCR primer pairs in human, mouse for UNC5B   OriGene Purified Protein for UNC5B  
     OriGene ORF clones in mouse, rat for UNC5B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UNC5B   OriGene Custom Protein Services for UNC5B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UNC5B
     QIAGEN SeqTarget long-range PCR primers for resequencing UNC5B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5B
     GenScript Custom Purified and Recombinant Proteins Services for UNC5B GenScript cDNA clones with any tag delivered in your preferred vector for UNC5B
     GenScript Custom Assay Services for UNC5B GenScript Custom Superior Antibodies Services for UNC5B
     GenScript Custom overexpressing Cell Line Services for UNC5B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UNC5B promoter
     Search Chromatin IP Primers for UNC5B
     RT2 qPCR Primer Assay in human, mouse, rat UNC5B
     GNC Network for UNC5B
     SABiosciences PCR Arrays including human, mouse, rat UNC5B
     Search Tocris compounds for UNC5B
     Proteins and Antibodies for UNC5B
     Cell Lysates for UNC5B
     cDNA Clones for UNC5B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for UNC5B
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UNC5B antibodies
     UNC5B proteins
     Antibodies for UNC5B
     See all of Abcam's Antibodies, Kits and Proteins for UNC5B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UNC5B
     Antibodies for UNC5B
     ELISAs for UNC5B
     CLIAs for UNC5B
     Search LifeMap BioReagents cell lines for UNC5B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5B
     SwitchGear 3'UTR luciferase reporter plasmids for UNC5B
     SwitchGear Promoter luciferase reporter plasmids for UNC5B
     Search ThermoFisher Antibodies for UNC5B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UNC5B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UNC5B
    Customized:
     lentivirus for stable overexpression of UNC5B
     lentivirus expression plasmids for stable overexpression of UNC5B
     adenovirus for overexpression of UNC5B
     LSBio Antibodies in human, mouse, rat for UNC5B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UNC5B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4