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Aliases for UNC5B Gene

Aliases for UNC5B Gene

  • Unc-5 Netrin Receptor B 2 3 5
  • P53-Regulated Receptor For Death And Life Protein 1 3 4
  • Protein Unc-5 Homolog 2 3 4
  • Protein Unc-5 Homolog B 3 4
  • P53RDL1 3 4
  • UNC5H2 3 4
  • Transmembrane Receptor Unc5H2 3
  • Unc-5 Homolog B (C. Elegans) 2
  • Unc5 (C.Elegans Homolog) B 2
  • Unc-5 Homolog 2 3
  • Unc-5 Homolog B 3

External Ids for UNC5B Gene

Previous GeneCards Identifiers for UNC5B Gene

  • GC00U990539
  • GC10P072864
  • GC10P072316
  • GC10P072642
  • GC10P072972
  • GC10P066966

Summaries for UNC5B Gene

Entrez Gene Summary for UNC5B Gene

  • This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for UNC5B Gene

UNC5B (Unc-5 Netrin Receptor B) is a Protein Coding gene. Among its related pathways are Axon guidance and Developmental Biology. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for UNC5B Gene

  • Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5B Gene

Genomics for UNC5B Gene

Regulatory Elements for UNC5B Gene

Enhancers for UNC5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UNC5B on UCSC Golden Path with GeneCards custom track

Promoters for UNC5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UNC5B on UCSC Golden Path with GeneCards custom track

Genomic Location for UNC5B Gene

Chromosome:
10
Start:
71,212,535 bp from pter
End:
71,302,879 bp from pter
Size:
90,345 bases
Orientation:
Plus strand

Genomic View for UNC5B Gene

Genes around UNC5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5B Gene

Proteins for UNC5B Gene

  • Protein details for UNC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZJ1-UNC5B_HUMAN
    Recommended name:
    Netrin receptor UNC5B
    Protein Accession:
    Q8IZJ1
    Secondary Accessions:
    • Q5T3R9
    • Q5T3S0
    • Q86SN3
    • Q8N1Y2
    • Q9H9F3

    Protein attributes for UNC5B Gene

    Size:
    945 amino acids
    Molecular mass:
    103638 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part (PubMed:12359238). Interacts (via death domain) with DAPK1 (via death domain) (PubMed:15729359, PubMed:18582460). Interacts (via extracellular domain) with FLRT3 (via extracellular domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with FLRT2 and FLRT3 (via extracellular domain), but has higher affinity for FLRT3 (PubMed:25374360). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (PubMed:26235030).
    Miscellaneous:
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.
    SequenceCaution:
    • Sequence=BAB14276.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04382.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UNC5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5B Gene

Proteomics data for UNC5B Gene at MOPED

Post-translational modifications for UNC5B Gene

  • Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
  • Phosphorylated on cytoplasmic tyrosine residues.
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Glycosylation at Asn 222 and Asn 347
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC5B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UNC5B (UNC5B)
  • Abcam antibodies for UNC5B

No data available for DME Specific Peptides for UNC5B Gene

Domains & Families for UNC5B Gene

Gene Families for UNC5B Gene

Suggested Antigen Peptide Sequences for UNC5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZJ1

UniProtKB/Swiss-Prot:

UNC5B_HUMAN :
  • Contains 1 death domain.
  • Belongs to the unc-5 family.
Domain:
  • Contains 1 death domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 2 TSP type-1 domains.
  • Contains 1 ZU5 domain.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5B: view

Function for UNC5B Gene

Molecular function for UNC5B Gene

UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
UniProtKB/Swiss-Prot Induction:
By p53/TP53.
genes like me logo Genes that share phenotypes with UNC5B: view

Animal Models for UNC5B Gene

MGI Knock Outs for UNC5B:

Animal Model Products

  • Taconic Biosciences Mouse Models for UNC5B

miRNA for UNC5B Gene

miRTarBase miRNAs that target UNC5B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC5B Gene

Localization for UNC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5B Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=Associated with lipid rafts. {ECO:0000250 UniProtKB:O08722}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5B Gene COMPARTMENTS Subcellular localization image for UNC5B gene
Compartment Confidence
plasma membrane 4
extracellular 3
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for UNC5B Gene

Pathways & Interactions for UNC5B Gene

genes like me logo Genes that share pathways with UNC5B: view

Pathways by source for UNC5B Gene

Gene Ontology (GO) - Biological Process for UNC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006915 apoptotic process IEA,TAS --
GO:0007165 signal transduction IEA --
GO:0012501 programmed cell death TAS --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 18469807
genes like me logo Genes that share ontologies with UNC5B: view

No data available for SIGNOR curated interactions for UNC5B Gene

Drugs & Compounds for UNC5B Gene

No Compound Related Data Available

Transcripts for UNC5B Gene

mRNA/cDNA for UNC5B Gene

Unigene Clusters for UNC5B Gene

Unc-5 homolog B (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - - -
SP3:
SP4:

Relevant External Links for UNC5B Gene

GeneLoc Exon Structure for
UNC5B
ECgene alternative splicing isoforms for
UNC5B

Expression for UNC5B Gene

mRNA expression in normal human tissues for UNC5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC5B Gene

This gene is overexpressed in Serum (41.6), Rectum (13.4), and Retina (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5B Gene



SOURCE GeneReport for Unigene cluster for UNC5B Gene Hs.522997

mRNA Expression by UniProt/SwissProt for UNC5B Gene

Q8IZJ1-UNC5B_HUMAN
Tissue specificity: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
genes like me logo Genes that share expression patterns with UNC5B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for UNC5B Gene

Orthologs for UNC5B Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UNC5B 35
  • 91.29 (n)
  • 95.24 (a)
UNC5B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC5B 35
  • 91.36 (n)
  • 95.66 (a)
UNC5B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc5b 35
  • 87.44 (n)
  • 92.38 (a)
Unc5b 16
Unc5b 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UNC5B 35
  • 97.43 (n)
  • 96.75 (a)
UNC5B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc5b 35
  • 87.2 (n)
  • 91.84 (a)
oppossum
(Monodelphis domestica)
Mammalia UNC5B 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC5B 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC5B 35
  • 80.96 (n)
  • 84.66 (a)
UNC5B 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC5B 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5b 35
  • 71.45 (n)
  • 80.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398393 35
zebrafish
(Danio rerio)
Actinopterygii unc5b 35
  • 68.57 (n)
  • 70.52 (a)
unc5b 36
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-5 35
  • 40.63 (n)
  • 32.14 (a)
Species with no ortholog for UNC5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC5B Gene

ENSEMBL:
Gene Tree for UNC5B (if available)
TreeFam:
Gene Tree for UNC5B (if available)

Paralogs for UNC5B Gene

(3) SIMAP similar genes for UNC5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNC5B: view

Variants for UNC5B Gene

Sequence variations from dbSNP and Humsavar for UNC5B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10509332 - 71,291,683(+) ATTTC(A/G/T)CCCGG nc-transcript-variant, reference, missense
rs34957097 - 71,286,860(+) CCGTC(A/G)TCGTC nc-transcript-variant, reference, missense
rs1538894 -- 71,261,011(-) AATAG(C/T)GAACC intron-variant
rs1538896 -- 71,220,256(+) ACTTT(C/T)TAAGC intron-variant
rs1538897 -- 71,220,478(+) CTCCC(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5B Gene

Variant ID Type Subtype PubMed ID
esv270237 CNV Insertion 20981092
nsv895712 CNV Loss 21882294
nsv528622 CNV Loss 19592680
nsv895713 CNV Loss 21882294
esv2738251 CNV Deletion 23290073
nsv25434 CNV Loss 16902084
esv2738262 CNV Deletion 23290073
esv2738273 CNV Deletion 23290073

Variation tolerance for UNC5B Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UNC5B Gene

Disorders for UNC5B Gene

Relevant External Links for UNC5B

Genetic Association Database (GAD)
UNC5B
Human Genome Epidemiology (HuGE) Navigator
UNC5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC5B

No disorders were found for UNC5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5B Gene

Publications for UNC5B Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K. … Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23 67
  2. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. (PMID: 20693423) Tadagavadi R.K. … Ramesh G. (J. Immunol. 2010) 2 3
  3. [Correlation of netrin-1 expression with invasion of extra villous trophoblasts]. (PMID: 19570425) Yang Y. … Zou L. (Zhonghua Fu Chan Ke Za Zhi 2009) 3 23
  4. Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis. (PMID: 19822088) Schubert T. … Bosserhoff A.K. (Int J Immunopathol Pharmacol 2009) 3 23
  5. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. (PMID: 18719102) Lejmi E. … PlouAt J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23

Products for UNC5B Gene

Sources for UNC5B Gene

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