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Aliases for UNC5B Gene

Aliases for UNC5B Gene

  • Unc-5 Homolog B (C. Elegans) 2 3
  • UNC5H2 3 4 6
  • P53-Regulated Receptor For Death And Life Protein 1 3 4
  • Protein Unc-5 Homolog 2 3 4
  • Protein Unc-5 Homolog B 3 4
  • P53RDL1 3 4
  • Transmembrane Receptor Unc5H2 3
  • Unc5 (C.Elegans Homolog) B 2
  • Netrin Receptor UNC5B 3
  • Unc-5 Homolog 2 3

External Ids for UNC5B Gene

Summaries for UNC5B Gene

Entrez Gene Summary for UNC5B Gene

  • This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for UNC5B Gene

UNC5B (Unc-5 Homolog B (C. Elegans)) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. An important paralog of this gene is UNC5D.

UniProtKB/Swiss-Prot for UNC5B Gene

  • Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5B Gene

Genomics for UNC5B Gene

Genomic Location for UNC5B Gene

Start:
71,212,535 bp from pter
End:
71,302,878 bp from pter
Size:
90,344 bases
Orientation:
Plus strand

Genomic View for UNC5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNC5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5B Gene

Regulatory Elements for UNC5B Gene

Proteins for UNC5B Gene

  • Protein details for UNC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZJ1-UNC5B_HUMAN
    Recommended name:
    Netrin receptor UNC5B
    Protein Accession:
    Q8IZJ1
    Secondary Accessions:
    • Q5T3R9
    • Q5T3S0
    • Q86SN3
    • Q8N1Y2
    • Q9H9F3

    Protein attributes for UNC5B Gene

    Size:
    945 amino acids
    Molecular mass:
    103638 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain).
    Miscellaneous:
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers
    SequenceCaution:
    • Sequence=BAB14276.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04382.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UNC5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5B Gene

Proteomics data for UNC5B Gene at MOPED

Post-translational modifications for UNC5B Gene

  • Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity.
  • Phosphorylated on cytoplasmic tyrosine residues.
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn222 and Asn347

Other Protein References for UNC5B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC5B Gene

Domains for UNC5B Gene

Gene Families for UNC5B Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

UniProtKB/Swiss-Prot:

UNC5B_HUMAN
Domain:
  • Contains 1 death domain.:
    • Q8IZJ1
  • Contains 1 Ig-like (immunoglobulin-like) domain.:
    • Q8IZJ1
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q8IZJ1
  • Contains 2 TSP type-1 domains.:
    • Q8IZJ1
  • Contains 1 ZU5 domain.:
    • Q8IZJ1
Family:
  • Belongs to the unc-5 family.:
    • Q8IZJ1
genes like me logo Genes that share domains with UNC5B: view

Function for UNC5B Gene

Molecular function for UNC5B Gene

UniProtKB/Swiss-Prot Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
UniProtKB/Swiss-Prot Induction: By p53/TP53

Gene Ontology (GO) - Molecular Function for UNC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18469807
genes like me logo Genes that share ontologies with UNC5B: view
genes like me logo Genes that share phenotypes with UNC5B: view

Animal Models for UNC5B Gene

MGI Knock Outs for UNC5B:

miRNA for UNC5B Gene

miRTarBase miRNAs that target UNC5B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for UNC5B Gene

Localization for UNC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5B Gene

Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5B Gene COMPARTMENTS Subcellular localization image for UNC5B gene
Compartment Confidence
plasma membrane 3
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for UNC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC5B: view

Pathways for UNC5B Gene

genes like me logo Genes that share pathways with UNC5B: view

Pathways by source for UNC5B Gene

1 KEGG pathway for UNC5B Gene

Gene Ontology (GO) - Biological Process for UNC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0007165 signal transduction --
GO:0007411 axon guidance TAS --
GO:0012501 programmed cell death TAS --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 18469807
genes like me logo Genes that share ontologies with UNC5B: view

Transcripts for UNC5B Gene

mRNA/cDNA for UNC5B Gene

Unigene Clusters for UNC5B Gene

Unc-5 homolog B (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - - -
SP3:
SP4:

Relevant External Links for UNC5B Gene

GeneLoc Exon Structure for
UNC5B
ECgene alternative splicing isoforms for
UNC5B

Expression for UNC5B Gene

mRNA expression in normal human tissues for UNC5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UNC5B Gene

SOURCE GeneReport for Unigene cluster for UNC5B Gene Hs.522997

mRNA Expression by UniProt/SwissProt for UNC5B Gene

Q8IZJ1-UNC5B_HUMAN
Tissue specificity: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
genes like me logo Genes that share expressions with UNC5B: view

Orthologs for UNC5B Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC5B 36
  • 97.43 (n)
  • 96.75 (a)
UNC5B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC5B 36
  • 91.29 (n)
  • 95.24 (a)
UNC5B 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC5B 36
  • 91.36 (n)
  • 95.66 (a)
UNC5B 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc5b 36
  • 87.44 (n)
  • 92.38 (a)
Unc5b 16
Unc5b 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNC5B 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC5B 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc5b 36
  • 87.2 (n)
  • 91.84 (a)
chicken
(Gallus gallus)
Aves UNC5B 36
  • 80.96 (n)
  • 84.66 (a)
UNC5B 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC5B 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398393 36
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5b 36
  • 71.45 (n)
  • 80.88 (a)
zebrafish
(Danio rerio)
Actinopterygii unc5b 36
  • 68.57 (n)
  • 70.52 (a)
unc5b 37
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-5 36
  • 40.63 (n)
  • 32.14 (a)
Species with no ortholog for UNC5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC5B Gene

ENSEMBL:
Gene Tree for UNC5B (if available)
TreeFam:
Gene Tree for UNC5B (if available)

Paralogs for UNC5B Gene

Paralogs for UNC5B Gene

Selected SIMAP similar genes for UNC5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNC5B: view

Variants for UNC5B Gene

Sequence variations from dbSNP and Humsavar for UNC5B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs13419 -- 71,299,632(+) GTTCC(A/G)TGGGT utr-variant-3-prime
rs17099 -- 71,225,777(-) TGGCA(C/T)TTACG intron-variant
rs869454 -- 71,294,849(-) CTGGC(A/G)GGGGA intron-variant
rs870485 -- 71,260,068(-) CATGC(C/T)CCCCC intron-variant
rs875001 -- 71,224,940(-) TACAG(C/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5B Gene

Variant ID Type Subtype PubMed ID
esv270237 CNV Insertion 20981092
nsv895712 CNV Loss 21882294
nsv528622 CNV Loss 19592680
nsv895713 CNV Loss 21882294
esv2738251 CNV Deletion 23290073
nsv25434 CNV Loss 16902084
esv2738262 CNV Deletion 23290073
esv2738273 CNV Deletion 23290073

Relevant External Links for UNC5B Gene

HapMap Linkage Disequilibrium report
UNC5B

Disorders for UNC5B Gene

(1) Novoseek inferred disease relationships for UNC5B Gene

Disease -log(P) Hits PubMed IDs
cancer 0 3

Relevant External Links for UNC5B

Genetic Association Database (GAD)
UNC5B
Human Genome Epidemiology (HuGE) Navigator
UNC5B
genes like me logo Genes that share disorders with UNC5B: view

No data available for UniProtKB/Swiss-Prot for UNC5B Gene

Publications for UNC5B Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K. … Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  2. Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H. (PMID: 18582460) Maisse C. … Hueber A.O. (Exp. Cell Res. 2008) 4 23
  3. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. (PMID: 18719102) Lejmi E. … PlouAt J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  4. [Correlation of netrin-1 expression with invasion of extra villous trophoblasts]. (PMID: 19570425) Yang Y. … Zou L. (Zhonghua Fu Chan Ke Za Zhi 2009) 3 23
  5. Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis. (PMID: 19822088) Schubert T. … Bosserhoff A.K. (Int J Immunopathol Pharmacol 2009) 3 23

Products for UNC5B Gene

Sources for UNC5B Gene

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