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UNC5B Gene

protein-coding   GIFtS: 62
GCID: GC10P072972

Unc-5 Homolog B (C. Elegans)

(Previous name: unc5 (C.elegans homolog) b)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-5 Homolog B (C. Elegans)1 2     Netrin Receptor UNC5B2
UNC5H22 3 5     p53RDL12
Protein Unc-5 Homolog 22 3     Transmembrane Receptor Unc5H22
Protein Unc-5 Homolog B2 3     Unc-5 Homolog 22
P53-Regulated Receptor For Death And Life Protein 12 3     P53RDL13
Unc5 (C.Elegans Homolog) B1     

External Ids:    HGNC: 125681   Entrez Gene: 2196992   Ensembl: ENSG000001077317   OMIM: 6078705   UniProtKB: Q8IZJ13   

Export aliases for UNC5B gene to outside databases

Previous GC identifers: GC00U990539 GC10P072864 GC10P072316 GC10P072642 GC10P066966


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UNC5B Gene:
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive
effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called
dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in
embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for
this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for UNC5B Gene:
UNC5B (unc-5 homolog B (C. elegans)) is a protein-coding gene. An important paralog of this gene is BAI1.

UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1,
activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic
activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the UNC5B gene promoter:
         MZF-1   POU2F1   p53   POU2F1a   MIF-1   POU6F1 (c2)   Nkx2-5   Tal-1beta   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC5B promoter sequence
   Search Chromatin IP Primers for UNC5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNC5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.2

UNC5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P072972:  view genomic region     (about GC identifiers)

Start:
72,972,298 bp from pter      End:
73,062,621 bp from pter
Size:
90,324 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1 (See protein sequence)
Recommended Name: Netrin receptor UNC5B precursor  
Size: 945 amino acids; 103638 Da
Subunit: Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic
part. Interacts (via death domain) with DAPK1 (via death domain)
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or
kidney cancers
Sequence caution: Sequence=BAB14276.1; Type=Erroneous initiation; Sequence=BAC04382.1; Type=Erroneous initiation;
Secondary accessions: Q5T3R9 Q5T3S0 Q86SN3 Q8N1Y2 Q9H9F3
Alternative splicing: 2 isoforms:  Q8IZJ1-1   Q8IZJ1-2   

Explore the universe of human proteins at neXtProt for UNC5B: NX_Q8IZJ1

Explore proteomics data for UNC5B at MOPED

Post-translational modifications: 

  • Phosphorylated on cytoplasmic tyrosine residues (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is
    associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis1
  • Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity1
  • Glycosylation2 at Asn222, Asn347
  • Modification sites at PhosphoSitePlus

  • See UNC5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231818.1  NP_734465.2  

    ENSEMBL proteins: 
     ENSP00000334329   ENSP00000362288  
    Reactome Protein details: Q8IZJ1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set
     IPR000906 ZU5

    Graphical View of Domain Structure for InterPro Entry Q8IZJ1

    ProtoNet protein and cluster: Q8IZJ1

    4 Blocks protein domains:
    IPB000488 Death domain
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 2 TSP type-1 domains
    Similarity: Contains 1 ZU5 domain


    Find genes that share domains with UNC5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC5B_HUMAN, Q8IZJ1
    Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
    developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
    with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
    induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1,
    activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic
    activity
    Induction: By p53/TP53

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18469807
         
    Find genes that share ontologies with UNC5B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UNC5B:
     Increased cell number in G1, a 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Unc5b):
     cardiovascular system  cellular  embryogenesis  hearing/vestibular/ear  mortality/aging 
     nervous system 

    Find genes that share phenotypes with UNC5B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Unc5btm1.1Dyl for UNC5B

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    Block miRNA regulation of human, mouse, rat UNC5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UNC5B (see all 33):
    hsa-miR-579 hsa-miR-3685 hsa-miR-15a hsa-miR-765 hsa-miR-424 hsa-miR-629 hsa-miR-15b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidUNC5B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UNC5B_HUMAN, Q8IZJ1: Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UNC5B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UNC5B About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Role of DCC in regulating apoptosis0.00
    Apoptosis0.38
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Netrin-1 signaling
    Netrin-1 signaling
    Netrin mediated repulsion signals0.00
    4Netrin Signaling
    Netrin Signaling
    5Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility


    Find genes that share SuperPaths with UNC5B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UNC5B
        Guidance Cues and Growth Cone Motility
    Netrin Signaling


    3 Reactome Pathways for UNC5B
        Netrin mediated repulsion signals
    Netrin-1 signaling
    Role of DCC in regulating apoptosis


    1 Kegg Pathway  (Kegg details for UNC5B):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNC5B
    Interactions:

        GeneGlobe Interaction Network for UNC5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for UNC5B (Q8IZJ11, 3 ENSP000003343294) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAPK1P533553, ENSP000003507854I2D: score=3 STRING: ENSP00000350785
    DCCENSP000003891404STRING: ENSP00000389140
    FYNENSP000003576564STRING: ENSP00000357656
    PIK3CAENSP000002639674STRING: ENSP00000263967
    UNC5AENSP000003327374STRING: ENSP00000332737
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance TAS--
    GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling IMP18469807
    GO:0033564anterior/posterior axon guidance IEA--

    Find genes that share ontologies with UNC5B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNC5B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UNC5B gene (2 alternative transcripts): 
    NM_001244889.1  NM_170744.4  

    Unigene Cluster for UNC5B:

    Unc-5 homolog B (C. elegans)
    Hs.522997  [show with all ESTs]
    Unigene Representative Sequence: NM_170744
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335350(uc001jro.3 uc001jrp.3) ENST00000373192
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UNC5B (see all 33):
    hsa-miR-579 hsa-miR-3685 hsa-miR-15a hsa-miR-765 hsa-miR-424 hsa-miR-629 hsa-miR-15b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidUNC5B 3' UTR sequence
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    Additional mRNA sequence: 

    AB096256.1 AK022859.1 AK094595.1 AK128132.1 AL049370.1 AY358351.1 

    6 DOTS entries:

    DT.91908160  DT.100774251  DT.75129932  DT.121221609  DT.121221632  DT.97843475 

    Selected AceView cDNA sequences (see all 158):

    AI344433 BQ182589 AK128132 AI815208 BM664591 AA911800 AA425121 AW519158 
    CA439546 F05244 AW663564 AK094595 AA873508 AW135129 AL049370 CA776404 
    BM696085 BQ447630 AW054966 CB044308 CB306604 AA897641 AI250054 AI144009 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
    SP1:        -     -                                                                                   -                                 
    SP2:        -     -                                               -                                   -                                 
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for UNC5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UNC5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTTAGTT
    UNC5B Expression
    About this image


    UNC5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Tip Cells Arteries
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
    UNC5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNC5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522997

    UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1
    Tissue specificity: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney
    and hematopoietic and immune tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UNC5B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc5b1 , 5 unc-5 homolog B (C. elegans)1, 5 87.44(n)1
    92.38(a)1
      10 (31.52 cM)5
    1074491  NM_029770.21  NP_084046.21 
     607626105 
    chicken
    (Gallus gallus)
    Aves UNC5B1 unc-5 homolog B (C. elegans) 80.96(n)
    84.66(a)
      423716  NM_001031225.2  NP_001026396.2 
    lizard
    (Anolis carolinensis)
    Reptilia UNC5B6
    unc-5 homolog B (C. elegans)
    82(a)
    1 ↔ 1
    3(47541495-47842610)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983932 UNC-5 receptor 76.71(n)    AY099459.1 
    zebrafish
    (Danio rerio)
    Actinopterygii unc5b1 unc-5 homolog B (C. elegans) 68.57(n)
    70.52(a)
      494130  NM_001111149.1  NP_001104619.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-51 unc-5 40.63(n)
    32.14(a)
      177334  NM_068422.5  NP_500823.1 


    ENSEMBL Gene Tree for UNC5B (if available)
    TreeFam Gene Tree for UNC5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UNC5B gene
    BAI12  UNC5C2  UNC5A2  UNC5CL2  CFP2  BAI32  BAI22  UNC5D2  
    3 SIMAP similar genes for UNC5B using alignment to 1 protein entry:     UNC5B_HUMAN:
    UNC5C    UNC5A    UNC5D

    Find genes that share paralogs with UNC5B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UNC5B (see all 2141)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131459461,2
    C,F--72970338(+) TGGGGA/GGAGAG 2 -- us2k12Minor allele frequency- G:0.10CSA WA 119
    rs1838232361,2
    --72970352(+) GAACAC/TGCTGT 2 -- us2k10--------
    rs1130803031,2
    C,F--72970376(+) TGCCCG/ATCTCT 2 -- us2k12Minor allele frequency- A:0.10CSA WA 119
    rs1888418451,2
    --72970420(+) ACAACC/TTTGAC 2 -- us2k10--------
    rs1921061871,2
    --72970873(+) CTCAAC/TTGATG 2 -- us2k10--------
    rs728084481,2
    C,F--72971030(+) TGTGGA/GGAGGG 2 -- us2k12Minor allele frequency- G:0.04NA EA 240
    rs1152308951,2
    C,F--72971031(+) GTGGAG/AAGGGT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1146209291,2
    C,F--72971089(+) CCCTTC/TGCACA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1151771301,2
    F--72971090(+) CCTTCG/ACACAG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1418811851,2
    --72971125(+) TTCAAA/GTGAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC5B (72972298 - 73062621 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for UNC5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738262CNV Deletion23290073
    esv2738273CNV Deletion23290073
    esv2738251CNV Deletion23290073
    esv270237CNV Insertion20981092
    nsv25434CNV Loss16902084
    nsv528622CNV Loss19592680
    nsv895712CNV Loss21882294
    nsv895713CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC5B
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607870    OMIM disorders: --


    Find genes that share disorders with UNC5B           About GenesLikeMe

    1 Novoseek inferred disease relationship for UNC5B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 3 12655055 (2), 18582460 (1)

    Genetic Association Database (GAD): UNC5B
    Human Genome Epidemiology (HuGE) Navigator: UNC5B (2 documents)

    Export disorders for UNC5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UNC5B gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with UNC5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 9 Thiebault K.... Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. The dependence receptor UNC5H2 mediates apoptosis through DAP- kinase. (PubMed id 15729359)1, 2 Llambi F.... Mehlen P. (EMBO J. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. p53RDL1 regulates of p53-dependent apoptosis. (PubMed id 12598906)1, 2 Tanikawa C.... Arakawa H. (Nat. Cell Biol. 2003)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)1, 2 Komatsuzaki K.... Kinane T.B. (Biochem. Biophys. Res. Commun. 2002)
    10. Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H. (PubMed id 18582460)2, 9 Maisse C.... Hueber A.O. (Exp. Cell Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219699 HGNC: 12568 AceView: UNC5B Ensembl:ENSG00000107731 euGenes: HUgn219699
    ECgene: UNC5B Kegg: 219699 H-InvDB: UNC5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UNC5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UNC5B gene:
    Search GeneIP for patents involving UNC5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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