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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC5A Gene

protein-coding   GIFtS: 61
GCID: GC05P176237

unc-5 homolog A (C. elegans)

(Previous name: unc5 (C.elegans homolog) a )
 Explore 2 diseases affiliated with
UNC5A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UNC5A    

Aliases
for UNC5A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Unc-5 Homolog A (C. Elegans)1 2     Protein Unc-5 Homolog A2 3
UNC5H11 2 3 5     Netrin Receptor UNC5A2
Unc5 (C.Elegans Homolog) A1 2     Netrin Receptor Unc5h12
KIAA19761 3     Unc-5 Homolog 12
Protein Unc-5 Homolog 12 3     

External Ids:    HGNC: 125671   Entrez Gene: 902492   Ensembl: ENSG000001137637   OMIM: 6078695   UniProtKB: Q6ZN443   

Export aliases for UNC5A gene to outside databases

Previous GC identifers: GC00U990540 GC05P176270 GC05P176170 GC05P171160


Summaries
for UNC5A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UNC5A:
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1
on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with
DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction
when not associated with netrin ligand

Gene Wiki entry for UNC5A


Genomic Views
for UNC5A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC5A gene promoter:
         AP-2gamma   Arnt   Max   HSF2   AP-2beta   AP-2alpha   Zic3   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UNC5A promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.3

UNC5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176237:  view genomic region     (about GC identifiers)

Start:
 176,237,478 bp from pter      End:
 176,307,899 bp from pter
Size:
 70,422 bases      Orientation:
 plus strand

Proteins
for UNC5A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44 (See protein sequence)
Recommended Name: Netrin receptor UNC5A precursor  
Size: 842 amino acids; 92932 Da
Subunit: Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating
some interaction with PKC (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Note=The interaction with
PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones (By
similarity)
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney
cancers
Sequence caution: Sequence=BAB85562.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B2RXE6 Q8TF26 Q96GP4
Alternative splicing: 3 isoforms:  Q6ZN44-1   Q6ZN44-2   Q6ZN44-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNC5A: NX_Q6ZN44

Post-translational modifications:

  • Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated
    • with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZN44

    • UNC5A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_588610.2  
    ENSEMBL proteins: 
     ENSP00000332737   ENSP00000424067   ENSP00000421795   ENSP00000261961  
    Reactome Protein details: Q6ZN44
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UNC5A (UNC5H1)
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    Novus Biologicals UNC5A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UNC5A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    UNC5A for ontologies           About GeneDecksing



    UNC5A Antibody Products: 
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    Uscn Antibodies for UNC5A
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    Assay Products for UNC5A: 
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    Uscn ELISAs and CLIAs for UNC5A

    Protein Domains /
    Families
    for UNC5A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UNC5A for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q6ZN44

    ProtoNet protein and cluster: Q6ZN44

    3 Blocks protein families:
    IPB000488 Death domain
    IPB000884 Thrombospondin
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44
    Domain: The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis (By
    similarity)
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 ZU5 domain


    Function
    for UNC5A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44
    Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
    developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with
    DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction
    when not associated with netrin ligand
    Induction: By p53/TP53

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5A
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5A (see all 36):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-4267 hsa-let-7g hsa-miR-4325 hsa-let-7a hsa-miR-3908 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: UNC5A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC5A (see all 7)
    OriGene shRNA RFP: UNC5A
    OriGene siRNA: UNC5A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UNC5A

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC5A (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5A 

    Cell Line
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    Search LifeMap BioReagents cell lines for UNC5A

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005042netrin receptor activity ----


    UNC5A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for UNC5A:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Unc5a):
     cellular  nervous system 

    UNC5A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UNC5A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Ubiquitinated Orc1 is degraded by the proteasome
    		Regulation of Apoptosis0.79
    		Apoptosis0.31
    3Netrin mediated repulsion signals
    		Netrin mediated repulsion signals1.00
    4Role of DCC in regulating apoptosis
    		Role of DCC in regulating apoptosis1.00
    5Netrin Signaling
    		Netrin Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UNC5A
        Guidance Cues and Growth Cone Motility
    Netrin Signaling

    5/7        Reactome Pathways for UNC5A (see all 7)
        Netrin mediated repulsion signals
    Regulation of Apoptosis
    Developmental Biology
    Netrin-1 signaling
    Role of DCC in regulating apoptosis


    1         Kegg Pathway  (Kegg details for UNC5A):
        Axon guidance


    UNC5A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for UNC5A (Q6ZN443 ENSP000003327374) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=2 STRING: ENSP00000364847
    NTN1O956313, ENSP000001732294I2D: score=1 STRING: ENSP00000173229
    DAPK1P533553, ENSP000003507854I2D: score=1 STRING: ENSP00000350785
    DCCENSP000003891404STRING: ENSP00000389140
    RAC1ENSP000003484614STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance TAS--
    GO:0042981regulation of apoptotic process TAS--


    UNC5A for ontologies           About GeneDecksing



    Drugs & Compounds
    for UNC5A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC5A
    Search CenterWatch for drugs/clinical trials and news about UNC5A 

    Transcripts
    for UNC5A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UNC5A gene: 
    NM_133369.2  

    Unigene Cluster for UNC5A:

    Unc-5 homolog A (C. elegans)
    Hs.33191  [show with all ESTs]
    Unigene Representative Sequence: NM_133369
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329542(uc003mex.1 uc003mey.3) ENST00000513890(uc010jkg.1)
    ENST00000509580 ENST00000261961

    miRNA
    Products:             		 OriGene 3'-UTR Clone: UNC5A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5A
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5A (see all 36):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-4267 hsa-let-7g hsa-miR-4325 hsa-let-7a hsa-miR-3908 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: UNC5A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC5A (see all 7)
    OriGene shRNA RFP: UNC5A
    OriGene siRNA: UNC5A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5A
    Clone
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    GenScript: all cDNA clones in your preferred vector: UNC5A (NM_133369)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5A

    Additional cDNA sequence: 

    AK131380.1 BC009333.2 BC033727.1 BC122556.1 BC157824.1 

    8 DOTS entries:

    DT.303017  DT.440944  DT.91996076  DT.100021845  DT.100743049  DT.99996360  DT.120818188  DT.95360734 

    24/67 AceView cDNA sequences (see all 67):

    CK824949 BX282095 BC009333 BU195807 CR598115 BQ691915 BI818609 AB075856 
    BU729492 BM271771 BM479478 BQ689148 BC033727 AA400943 BM668454 AI334729 
    BF530640 BF311896 BG329812 BM272095 BE314370 BM713490 R19123 AA478265 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5A (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                        -     -     -     -     -                           
    SP2:                    -     -                             -                                                                                                   
    SP3:                    -     -                                                                                                                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for UNC5A

    Expression
    for UNC5A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAGCTCGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UNC5A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod Long BoneBone
    BoneEndochondral Facial BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    BoneZeugopod Long BoneBone
    CartilageMeckel's CartilageCartilage
    LimbAutopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UNC5A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC5A

    SOURCE GeneReport for Unigene cluster: Hs.33191
        SABiosciences Custom PCR Arrays for UNC5A
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5A
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5A

    Orthologs
    for UNC5A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UNC5A gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Unc5a1 , 5 unc-5 homolog A (C. elegans)1, 5 88.28(n)1
    93.47(a)1    		   13 (29.80 cM)5
    1074481  NM_153131.31  NP_694771.11 
     549494115 
    chicken
    (Gallus gallus)    		 Aves UNC5A1 unc-5 homolog A (C. elegans) 80.23(n)
    80.27(a)    		   426419  XM_424067.3  XP_424067.3 
    lizard
    (Anolis carolinensis)    		 Reptilia UNC5A6
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL343526.1(13711-36240)
    zebrafish
    (Danio rerio)    		 Actinopterygii unc5a1 unc-5 homolog A (C. elegans) 70.33(n)
    68.74(a)    		   799734  NM_001114465.1  NP_001107937.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta unc-56
    		 unc-5
    		 21(a)
    		 1 → many
    		 2R(11237659-11255807)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-56
    		 Netrin receptor unc-5
    		 9(a)
    		 possible ortholog
    		 IV(5495657-5516256)


    ENSEMBL Gene Tree for UNC5A (if available)
    TreeFam Gene Tree for UNC5A (if available) 

    Paralogs
    for UNC5A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC5A gene
    UNC5B2  BAI12  UNC5C2  UNC5CL2  CFP2  BAI32  BAI22  UNC5D2  
    4 SIMAP similar genes for UNC5A using alignment to 5 protein entries:     UNC5A_HUMAN (see all proteins):
    UNC5C    UNC5B    UNC5D    CFP

    UNC5A for paralogs           About GeneDecksing



    Genomic Variants
    for UNC5A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1470 NCBI SNPs in UNC5A are shown (see all 1470)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1489663171,2
    		--176235582(+) CCAAAA/GTGCTG 1 -- us2k10--------
    rs29627791,2
    		C,--176235754(+) GACTCA/TCCTCT 1 -- us2k1 trp310Minor allele frequency- T:0.07WA NA CSA 252
    rs723646811,2
    		C,--176235839(+) TCCTA-/ACCACAC 1 -- us2k10--------
    rs1436484641,2
    		--176235926(+) GCCCCA/GAAAGC 1 -- us2k10--------
    rs1924033791,2
    		--176236429(+) GGCCCC/GGTAGG 1 -- us2k10--------
    rs1510448291,2
    		--176236486(+) ACCCAA/GACTAG 1 -- us2k10--------
    rs1410845121,2
    		--176236513(+) GATCAC/TTCCCC 1 -- us2k10--------
    rs1833510941,2
    		--176236529(+) CACACC/TGCACG 1 -- us2k10--------
    rs9994561,2
    		C,F,A,H,--176236807(+) GGGTGC/TGCTGC 1 -- us2k116Minor allele frequency- T:0.10NS EA NA WA 1700
    rs1451660891,2
    		--176236846(+) GGCGCC/TGAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC5A (176237478 - 176307899 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for UNC5A
         3 CNVs: 51637 53250 51636
         4 Indels: 27871 69250 27872 34345

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    Disorders / Diseases
    for UNC5A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UNC5A for disorders           About GeneDecksing

    OMIM gene information: 607869    OMIM disorders: --

    2 diseases for UNC5A:    About MalaCards
    kidney cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for UNC5A:
    Colorectal cancer
    Human Genome Epidemiology (HuGE) Navigator: UNC5A (3 documents)

    Export disorders for UNC5A gene to outside databases

    Publications
    for UNC5A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC5A gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with UNC5A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 9 Thiebault K.... Mehlen P. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. p53RDL1 regulates of p53-dependent apoptosis. (PubMed id 12598906)1, 2 Tanikawa C.... Arakawa H. (2003)
    5. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
    6. Identification of UNC5A as a novel transcriptional ta rget of tumor suppressor p53 and a regulator of apoptosis. (PubMed id 20372800)1 Miyamoto Y....Arakawa H. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PubMed id 17174565)1 Qin S....Zhang C. (2007)
    10. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. (PubMed id 15729359)1 Llambi F....Mehlen P. (2005)

    External Searches for UNC5A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UNC5A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90249 HGNC: 12567 AceView: UNC5A Ensembl:ENSG00000113763 euGenes: HUgn90249
    ECgene: UNC5A Kegg: 90249 H-InvDB: UNC5A

    Other Databases showing UNC5A gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1976

    Specialized Databases showing UNC5A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC5A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UNC5A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UNC5A gene:
    Search GeneIP for patents involving UNC5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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