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UNC5A Gene

protein-coding   GIFtS: 61
GCID: GC05P176237

Unc-5 Homolog A (C. Elegans)

(Previous name: unc5 (C.elegans homolog) a)
  Search for UNC5A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-5 Homolog A (C. Elegans)1 2     Netrin Receptor UNC5A2
UNC5H12 3 5     Netrin Receptor Unc5h12
Unc5 (C.Elegans Homolog) A1 2     Unc-5 Homolog 12
Protein Unc-5 Homolog 12 3     KIAA19763
Protein Unc-5 Homolog A2 3     

External Ids:    HGNC: 125671   Entrez Gene: 902492   Ensembl: ENSG000001137637   OMIM: 6078695   UniProtKB: Q6ZN443   

Export aliases for UNC5A gene to outside databases

Previous GC identifers: GC00U990540 GC05P176270 GC05P176170 GC05P171160


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UNC5A Gene:
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of
netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).(supplied by OMIM, Apr
2004)

GeneCards Summary for UNC5A Gene:
UNC5A (unc-5 homolog A (C. elegans)) is a protein-coding gene. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
induction when not associated with netrin ligand

Gene Wiki entry for UNC5A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UNC5A gene promoter:
         AP-2gamma   Arnt   Max   HSF2   AP-2beta   AP-2alpha   Zic3   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC5A promoter sequence
   Search Chromatin IP Primers for UNC5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNC5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.3

UNC5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176237:  view genomic region     (about GC identifiers)

Start:
176,237,478 bp from pter      End:
176,307,899 bp from pter
Size:
70,422 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44 (See protein sequence)
Recommended Name: Netrin receptor UNC5A precursor  
Size: 842 amino acids; 92932 Da
Subunit: Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly
mediating some interaction with PKC (By similarity)
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or
kidney cancers
Sequence caution: Sequence=BAB85562.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B2RXE6 Q8TF26 Q96GP4
Alternative splicing: 3 isoforms:  Q6ZN44-1   Q6ZN44-2   Q6ZN44-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNC5A: NX_Q6ZN44

Explore proteomics data for UNC5A at MOPED

Post-translational modifications: 

  • Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is
    associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)1
  • Glycosylation2 at Asn107, Asn218, Asn287
  • Modification sites at PhosphoSitePlus

  • See UNC5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_588610.2  
    ENSEMBL proteins: 
     ENSP00000332737   ENSP00000424067   ENSP00000421795   ENSP00000261961  
    Reactome Protein details: Q6ZN44

    UNC5A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UNC5A (UNC5H1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Novus Biologicals UNC5A Protein
    Novus Biologicals UNC5A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UNC5A

     
    Search eBioscience for Proteins for UNC5A 

    UNC5A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for UNC5A at Abcam
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    LSBio Antibodies in human, mouse, rat for UNC5A

    UNC5A Assay Products:

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    Cloud-Clone Corp. ELISAs for UNC5A
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    Search eBioscience for ELISAs for UNC5A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set
     IPR000906 ZU5
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6ZN44

    ProtoNet protein and cluster: Q6ZN44

    3 Blocks protein domains:
    IPB000488 Death domain
    IPB000884 Thrombospondin
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44
    Domain: The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis (By
    similarity)
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 ZU5 domain


    Find genes that share domains with UNC5A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC5A_HUMAN, Q6ZN44
    Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
    developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
    with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
    induction when not associated with netrin ligand
    Induction: By p53/TP53

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with UNC5A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UNC5A:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Unc5a):
     cellular  nervous system 

    Find genes that share phenotypes with UNC5A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UNC5A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UNC5A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UNC5A

    miRNA
    Products:
        
    miRTarBase miRNAs that target UNC5A:
    hsa-mir-320a (MIRT044601)

    Block miRNA regulation of human, mouse, rat UNC5A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UNC5A (see all 36):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-4267 hsa-let-7g hsa-miR-4325 hsa-let-7a hsa-miR-3908 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidUNC5A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UNC5A
    Predesigned siRNA for gene silencing in human, mouse, rat UNC5A

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNC5A (NM_133369)
    Sino Biological Human cDNA Clone for UNC5A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UNC5A_HUMAN, Q6ZN44: Cell membrane; Single-pass type I membrane protein (By similarity). Note=The interaction
    with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UNC5A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UNC5A About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Role of DCC in regulating apoptosis0.00
    Apoptosis0.38
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Netrin-1 signaling
    Netrin-1 signaling
    Netrin mediated repulsion signals0.00
    4Netrin Signaling
    Netrin Signaling
    5Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility


    Find genes that share SuperPaths with UNC5A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UNC5A
        Guidance Cues and Growth Cone Motility
    Netrin Signaling


    3 Reactome Pathways for UNC5A
        Netrin mediated repulsion signals
    Netrin-1 signaling
    Role of DCC in regulating apoptosis


    1 Kegg Pathway  (Kegg details for UNC5A):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNC5A
    Interactions:

        GeneGlobe Interaction Network for UNC5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for UNC5A (Q6ZN443 ENSP000003327374) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=2 STRING: ENSP00000364847
    NTN1O956313, ENSP000001732294I2D: score=1 STRING: ENSP00000173229
    DAPK1P533553, ENSP000003507854I2D: score=1 STRING: ENSP00000350785
    DCCENSP000003891404STRING: ENSP00000389140
    RAC1ENSP000003484614STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance TAS--
    GO:0033564anterior/posterior axon guidance IEA--
    GO:0042981regulation of apoptotic process TAS--

    Find genes that share ontologies with UNC5A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNC5A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UNC5A gene: 
    NM_133369.2  

    Unigene Cluster for UNC5A:

    Unc-5 homolog A (C. elegans)
    Hs.33191  [show with all ESTs]
    Unigene Representative Sequence: NM_133369
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329542(uc003mex.1 uc003mey.3) ENST00000513890(uc010jkg.1)
    ENST00000509580 ENST00000261961
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UNC5A (see all 36):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-4267 hsa-let-7g hsa-miR-4325 hsa-let-7a hsa-miR-3908 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidUNC5A 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: UNC5A (NM_133369)
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      QuantiTect SYBR Green Assays in human, mouse, rat UNC5A
      QuantiFast Probe-based Assays in human, mouse, rat UNC5A

    Additional mRNA sequence: 

    AK131380.1 BC009333.2 BC033727.1 BC122556.1 BC157824.1 

    8 DOTS entries:

    DT.303017  DT.440944  DT.91996076  DT.100021845  DT.100743049  DT.99996360  DT.120818188  DT.95360734 

    Selected AceView cDNA sequences (see all 67):

    CK824949 BX282095 BU729492 BU195807 CR598115 BM479478 AB075856 BQ689148 
    BI818609 BQ691915 BM271771 BC009333 BF311804 BM272095 BG470852 BX453455 
    BM668454 AA400943 BG329812 AW872760 BF311896 BC033727 R19123 BF530640 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UNC5A (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                        -     -     -     -     -                           
    SP2:                    -     -                             -                                                                                                   
    SP3:                    -     -                                                                                                                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for UNC5A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UNC5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGCTCGT
    UNC5A Expression
    About this image


    UNC5A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Zeugopod Long Bone
     
     Limb (Muscoskeletal System)
             Autopod
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
    UNC5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNC5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.33191
        Custom PCR Arrays for UNC5A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UNC5A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UNC5A
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    QuantiFast Probe-based Assays in human, mouse, rat UNC5A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UNC5A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc5a1 , 5 unc-5 homolog A (C. elegans)1, 5 88.4(n)1
    93.11(a)1
      13 (29.80 cM)5
    1074481  NM_153131.31  NP_694771.11 
     549494115 
    chicken
    (Gallus gallus)
    Aves UNC5A1 unc-5 homolog A (C. elegans) 79.05(n)
    78.6(a)
      426419  XM_424067.4  XP_424067.4 
    lizard
    (Anolis carolinensis)
    Reptilia UNC5A6
    unc-5 homolog A (C. elegans)
    71(a)
    1 ↔ 1
    GL343526.1(13711-45710)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia unc5a1 unc-5 homolog A 68.5(n)
    69.03(a)
      100492616  NM_001100204.2  NP_001093674.2 
    zebrafish
    (Danio rerio)
    Actinopterygii unc5a1 unc-5 homolog A (C. elegans) 69.57(n)
    67.42(a)
      799734  NM_001114465.1  NP_001107937.1 


    ENSEMBL Gene Tree for UNC5A (if available)
    TreeFam Gene Tree for UNC5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UNC5A gene
    UNC5B2  BAI12  UNC5CL2  UNC5C2  BAI32  CFP2  BAI22  UNC5D2  
    4 SIMAP similar genes for UNC5A using alignment to 5 protein entries:     UNC5A_HUMAN (see all proteins):
    UNC5C    UNC5B    UNC5D    CFP

    Find genes that share paralogs with UNC5A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UNC5A (see all 1823)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887535041,2
    --171158941(+) ACGTCC/TGCCTC 1 -- int10--------
    rs1495761891,2
    C--171159021(+) CTGGC-/TGTGTGT
    GTGTGTGTG
    TGTGT
    1 -- int10--------
    rs1479028361,2
    C--171159106(+) TGACCC/TCAAGC 1 -- int10--------
    rs1489663171,2
    C--176235582(+) CCAAAA/GTGCTG 1 -- us2k10--------
    rs29627791,2
    C--176235754(+) GACTCA/TCCTCT 1 -- us2k1 trp310Minor allele frequency- T:0.07WA NA CSA 252
    rs723646811,2
    C--176235839(+) TCCTA-/ACCACAC 1 -- us2k10--------
    rs1436484641,2
    C--176235926(+) GCCCCA/GAAAGC 1 -- us2k10--------
    rs1924033791,2
    --176236429(+) GGCCCC/GGTAGG 1 -- us2k10--------
    rs1510448291,2
    C--176236486(+) ACCCAA/GACTAG 1 -- us2k10--------
    rs1410845121,2
    --176236513(+) GATCAC/TTCCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC5A (176237478 - 176307899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UNC5A (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1776918CNV Deletion17803354
    esv2731183CNV Deletion23290073
    esv1004326CNV Deletion20482838
    esv2731182CNV Deletion23290073
    esv1176499CNV Deletion17803354
    esv2670396CNV Deletion23128226
    esv2731180CNV Deletion23290073
    esv2666951CNV Deletion23128226
    esv1379063CNV Deletion17803354
    esv2731181CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC5A
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC5A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607869    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for UNC5A:
    Colorectal cancer

    Find genes that share disorders with UNC5A           About GenesLikeMe

    Genetic Association Database (GAD): UNC5A
    Human Genome Epidemiology (HuGE) Navigator: UNC5A (3 documents)

    Export disorders for UNC5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UNC5A gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with UNC5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 9 Thiebault K.... Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. p53RDL1 regulates of p53-dependent apoptosis. (PubMed id 12598906)1, 2 Tanikawa C.... Arakawa H. (Nat. Cell Biol. 2003)
    6. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    7. Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis. (PubMed id 20372800)1 Miyamoto Y....Arakawa H. (Int. J. Oncol. 2010)
    8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    9. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PubMed id 17174565)1 Qin S....Zhang C. (Mol. Cell. Neurosci. 2007)
    10. The dependence receptor UNC5H2 mediates apoptosis through DAP- kinase. (PubMed id 15729359)1 Llambi F.... Mehlen P. (EMBO J. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90249 HGNC: 12567 AceView: UNC5A Ensembl:ENSG00000113763 euGenes: HUgn90249
    ECgene: UNC5A Kegg: 90249 H-InvDB: UNC5A

    (According to HUGE)
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    HUGE: KIAA1976

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UNC5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UNC5A gene:
    Search GeneIP for patents involving UNC5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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