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Aliases for UNC5A Gene

Aliases for UNC5A Gene

  • Unc-5 Netrin Receptor A 2 3 5
  • Unc5 (C.Elegans Homolog) A 2 3
  • Protein Unc-5 Homolog 1 3 4
  • Protein Unc-5 Homolog A 3 4
  • UNC5H1 3 4
  • Unc-5 Homolog A (C. Elegans) 2
  • Netrin Receptor Unc5h1 3
  • Unc-5 Homolog 1 3
  • Unc-5 Homolog A 3
  • KIAA1976 4

External Ids for UNC5A Gene

Previous GeneCards Identifiers for UNC5A Gene

  • GC00U990540
  • GC05P176270
  • GC05P176170
  • GC05P171160
  • GC05P176237

Summaries for UNC5A Gene

Entrez Gene Summary for UNC5A Gene

  • UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]

GeneCards Summary for UNC5A Gene

UNC5A (Unc-5 Netrin Receptor A) is a Protein Coding gene. Among its related pathways are Axon guidance and Guidance Cues and Growth Cone Motility. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for UNC5A Gene

  • Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Gene Wiki entry for UNC5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5A Gene

Genomics for UNC5A Gene

Regulatory Elements for UNC5A Gene

Enhancers for UNC5A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UNC5A on UCSC Golden Path with GeneCards custom track

Genomic Location for UNC5A Gene

Chromosome:
5
Start:
176,810,477 bp from pter
End:
176,880,898 bp from pter
Size:
70,422 bases
Orientation:
Plus strand

Genomic View for UNC5A Gene

Genes around UNC5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5A Gene

Proteins for UNC5A Gene

  • Protein details for UNC5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN44-UNC5A_HUMAN
    Recommended name:
    Netrin receptor UNC5A
    Protein Accession:
    Q6ZN44
    Secondary Accessions:
    • B2RXE6
    • Q8TF26
    • Q96GP4

    Protein attributes for UNC5A Gene

    Size:
    842 amino acids
    Molecular mass:
    92932 Da
    Quaternary structure:
    • Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity). Interacts (via extracellular domain) with FLRT2 (via extracellular domain) (PubMed:25374360). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (By similarity).
    Miscellaneous:
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.
    SequenceCaution:
    • Sequence=BAB85562.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UNC5A Gene

    Alternative splice isoforms for UNC5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5A Gene

Proteomics data for UNC5A Gene at MOPED

Post-translational modifications for UNC5A Gene

  • Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC5A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC5A Gene

Domains & Families for UNC5A Gene

Gene Families for UNC5A Gene

Suggested Antigen Peptide Sequences for UNC5A Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZN44

UniProtKB/Swiss-Prot:

UNC5A_HUMAN :
  • The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.
  • Belongs to the unc-5 family.
Domain:
  • The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.
  • Contains 1 death domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 TSP type-1 domain.
  • Contains 1 ZU5 domain.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5A: view

Function for UNC5A Gene

Molecular function for UNC5A Gene

UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.
genes like me logo Genes that share phenotypes with UNC5A: view

Animal Models for UNC5A Gene

MGI Knock Outs for UNC5A:

Animal Model Products

  • Taconic Biosciences Mouse Models for UNC5A

miRNA for UNC5A Gene

miRTarBase miRNAs that target UNC5A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC5A Gene

Localization for UNC5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5A Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell projection. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. Detected in neurites. {ECO:0000250 UniProtKB:O08721}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5A Gene COMPARTMENTS Subcellular localization image for UNC5A gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UNC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032809 neuronal cell body membrane ISS --
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with UNC5A: view

Pathways & Interactions for UNC5A Gene

genes like me logo Genes that share pathways with UNC5A: view

SIGNOR curated interactions for UNC5A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UNC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007411 axon guidance TAS --
GO:0033564 anterior/posterior axon guidance IEA --
GO:0038007 netrin-activated signaling pathway ISS --
genes like me logo Genes that share ontologies with UNC5A: view

Drugs & Compounds for UNC5A Gene

No Compound Related Data Available

Transcripts for UNC5A Gene

Unigene Clusters for UNC5A Gene

Unc-5 homolog A (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1: - - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for UNC5A Gene

GeneLoc Exon Structure for
UNC5A
ECgene alternative splicing isoforms for
UNC5A

Expression for UNC5A Gene

mRNA expression in normal human tissues for UNC5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5A Gene

This gene is overexpressed in Brain - Cortex (x10.1), Brain - Cerebellum (x7.3), Brain - Frontal Cortex (BA9) (x7.0), Brain - Cerebellar Hemisphere (x6.1), and Brain - Anterior cingulate cortex (BA24) (x5.3).

Protein differential expression in normal tissues from HIPED for UNC5A Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5A Gene



SOURCE GeneReport for Unigene cluster for UNC5A Gene Hs.33191

genes like me logo Genes that share expression patterns with UNC5A: view

Protein tissue co-expression partners for UNC5A Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UNC5A Gene

Orthologs for UNC5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for UNC5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UNC5A 35
  • 92.12 (n)
  • 96.08 (a)
UNC5A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC5A 35
  • 92 (n)
  • 95.96 (a)
UNC5A 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc5a 35
  • 88.4 (n)
  • 93.11 (a)
Unc5a 16
Unc5a 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UNC5A 35
  • 99.11 (n)
  • 99.27 (a)
UNC5A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc5a 35
  • 87.33 (n)
  • 93.11 (a)
oppossum
(Monodelphis domestica)
Mammalia UNC5A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC5A 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC5A 35
  • 79.05 (n)
  • 78.6 (a)
UNC5A 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC5A 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5a 35
  • 68.5 (n)
  • 69.03 (a)
zebrafish
(Danio rerio)
Actinopterygii unc5a 35
  • 69.57 (n)
  • 67.42 (a)
unc5a 36
  • 65 (a)
OneToOne
Species with no ortholog for UNC5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UNC5A Gene

ENSEMBL:
Gene Tree for UNC5A (if available)
TreeFam:
Gene Tree for UNC5A (if available)

Paralogs for UNC5A Gene

(4) SIMAP similar genes for UNC5A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with UNC5A: view

Variants for UNC5A Gene

Sequence variations from dbSNP and Humsavar for UNC5A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs772666 -- 176,859,211(+) GGCAT(A/G)GCTGC intron-variant
rs772676 -- 176,841,939(-) attac(A/C)ggcgt intron-variant
rs772677 -- 176,841,822(-) cgagc(A/C)ttttt intron-variant
rs809546 -- 176,859,331(+) GGCAT(A/G)GCTGC intron-variant
rs811313 -- 176,859,361(+) GGCAT(A/G)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5A Gene

Variant ID Type Subtype PubMed ID
nsv462557 CNV Loss 19166990
dgv6376n71 CNV Loss 21882294
nsv509100 CNV Insertion 20534489
dgv6377n71 CNV Loss 21882294
dgv6378n71 CNV Loss 21882294
dgv732n27 CNV Loss 19166990
esv2666951 CNV Deletion 23128226
nsv883155 CNV Loss 21882294
nsv462562 CNV Loss 19166990
esv2731180 CNV Deletion 23290073
nsv328116 CNV Loss 16902084
esv2731181 CNV Deletion 23290073
esv21826 CNV Gain 19812545
esv1663529 CNV Insertion 17803354
esv1776918 CNV Deletion 17803354
esv2731182 CNV Deletion 23290073
esv2670396 CNV Deletion 23128226
nsv513275 CNV Loss 21212237
esv1379063 CNV Deletion 17803354
esv2731183 CNV Deletion 23290073
esv1004326 CNV Deletion 20482838
esv1176499 CNV Deletion 17803354
dgv362n21 CNV Loss 19592680

Variation tolerance for UNC5A Gene

Residual Variation Intolerance Score: 9.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC5A Gene

HapMap Linkage Disequilibrium report
UNC5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5A Gene

Disorders for UNC5A Gene

Relevant External Links for UNC5A

Genetic Association Database (GAD)
UNC5A
Human Genome Epidemiology (HuGE) Navigator
UNC5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC5A

No disorders were found for UNC5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5A Gene

Publications for UNC5A Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K. … Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23 67
  2. Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis. (PMID: 20372800) Miyamoto Y. … Arakawa H. (Int. J. Oncol. 2010) 2 3
  3. The Fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis. (PMID: 24676280) Huang F. … Carreau M. (PLoS ONE 2014) 3
  4. DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer. (PMID: 24737586) Zhu Y. … Bi J. (Tumour Biol. 2014) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for UNC5A Gene

Sources for UNC5A Gene

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