Aliases for UNC5A Gene
External Ids for UNC5A Gene
Previous GeneCards Identifiers for UNC5A Gene
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
GeneCards Summary for UNC5A Gene
UNC5A (Unc-5 Netrin Receptor A) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Guidance Cues and Growth Cone Motility. An important paralog of this gene is UNC5C.
UniProtKB/Swiss-Prot for UNC5A Gene
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.