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Aliases for UNC5A Gene

Aliases for UNC5A Gene

  • Unc-5 Homolog A (C. Elegans) 2 3
  • UNC5H1 3 4 6
  • Unc5 (C.Elegans Homolog) A 2 3
  • Protein Unc-5 Homolog 1 3 4
  • Protein Unc-5 Homolog A 3 4
  • Netrin Receptor Unc5h1 3
  • Netrin Receptor UNC5A 3
  • Unc-5 Homolog 1 3
  • KIAA1976 4

External Ids for UNC5A Gene

Previous GeneCards Identifiers for UNC5A Gene

  • GC00U990540
  • GC05P176270
  • GC05P176170
  • GC05P171160
  • GC05P176237

Summaries for UNC5A Gene

Entrez Gene Summary for UNC5A Gene

  • UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]

GeneCards Summary for UNC5A Gene

UNC5A (Unc-5 Homolog A (C. Elegans)) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. An important paralog of this gene is UNC5D.

UniProtKB/Swiss-Prot for UNC5A Gene

  • Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand

Gene Wiki entry for UNC5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5A Gene

Genomics for UNC5A Gene

Regulatory Elements for UNC5A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UNC5A Gene

Start:
176,810,477 bp from pter
End:
176,880,898 bp from pter
Size:
70,422 bases
Orientation:
Plus strand

Genomic View for UNC5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNC5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5A Gene

Proteins for UNC5A Gene

  • Protein details for UNC5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN44-UNC5A_HUMAN
    Recommended name:
    Netrin receptor UNC5A
    Protein Accession:
    Q6ZN44
    Secondary Accessions:
    • B2RXE6
    • Q8TF26
    • Q96GP4

    Protein attributes for UNC5A Gene

    Size:
    842 amino acids
    Molecular mass:
    92932 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity).
    Miscellaneous:
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers
    SequenceCaution:
    • Sequence=BAB85562.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UNC5A Gene

    Alternative splice isoforms for UNC5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5A Gene

Proteomics data for UNC5A Gene at MOPED

Post-translational modifications for UNC5A Gene

  • Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro (By similarity).
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity).
  • Glycosylation at Asn107, Asn218, and Asn287
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC5A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC5A Gene

Domains for UNC5A Gene

Gene Families for UNC5A Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for UNC5A Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZN44

UniProtKB/Swiss-Prot:

UNC5A_HUMAN :
  • Q6ZN44
Domain:
  • The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.
  • Contains 1 death domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 TSP type-1 domain.
  • Contains 1 ZU5 domain.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5A: view

Function for UNC5A Gene

Molecular function for UNC5A Gene

UniProtKB/Swiss-Prot Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand
UniProtKB/Swiss-Prot Induction: By p53/TP53.

Gene Ontology (GO) - Molecular Function for UNC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with UNC5A: view
genes like me logo Genes that share phenotypes with UNC5A: view

Animal Model Products

CRISPR Products

miRNA for UNC5A Gene

miRTarBase miRNAs that target UNC5A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNC5A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UNC5A Gene

Localization for UNC5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5A Gene

Cell membrane; Single-pass type I membrane protein. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC5A Gene COMPARTMENTS Subcellular localization image for UNC5A gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UNC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC5A: view

Pathways for UNC5A Gene

genes like me logo Genes that share pathways with UNC5A: view

Pathways by source for UNC5A Gene

1 KEGG pathway for UNC5A Gene

Gene Ontology (GO) - Biological Process for UNC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0007165 signal transduction --
GO:0007411 axon guidance TAS --
GO:0012501 programmed cell death TAS --
GO:0033564 anterior/posterior axon guidance IEA --
genes like me logo Genes that share ontologies with UNC5A: view

Transcripts for UNC5A Gene

Unigene Clusters for UNC5A Gene

Unc-5 homolog A (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNC5A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UNC5A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1: - - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for UNC5A Gene

GeneLoc Exon Structure for
UNC5A
ECgene alternative splicing isoforms for
UNC5A

Expression for UNC5A Gene

mRNA expression in normal human tissues for UNC5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5A Gene

This gene is overexpressed in Brain - Cortex (10.1), Brain - Cerebellum (7.3), Brain - Frontal Cortex (BA9) (7.0), Brain - Cerebellar Hemisphere (6.1), and Brain - Anterior cingulate cortex (BA24) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UNC5A Gene

SOURCE GeneReport for Unigene cluster for UNC5A Gene Hs.33191

genes like me logo Genes that share expressions with UNC5A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UNC5A Gene

Orthologs for UNC5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for UNC5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC5A 35
  • 99.11 (n)
  • 99.27 (a)
UNC5A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC5A 35
  • 92.12 (n)
  • 96.08 (a)
UNC5A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC5A 35
  • 92 (n)
  • 95.96 (a)
UNC5A 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc5a 35
  • 88.4 (n)
  • 93.11 (a)
Unc5a 16
Unc5a 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNC5A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC5A 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc5a 35
  • 87.33 (n)
  • 93.11 (a)
chicken
(Gallus gallus)
Aves UNC5A 35
  • 79.05 (n)
  • 78.6 (a)
UNC5A 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC5A 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5a 35
  • 68.5 (n)
  • 69.03 (a)
zebrafish
(Danio rerio)
Actinopterygii unc5a 35
  • 69.57 (n)
  • 67.42 (a)
unc5a 36
  • 65 (a)
OneToOne
Species with no ortholog for UNC5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UNC5A Gene

ENSEMBL:
Gene Tree for UNC5A (if available)
TreeFam:
Gene Tree for UNC5A (if available)

Paralogs for UNC5A Gene

Paralogs for UNC5A Gene

Selected SIMAP similar genes for UNC5A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with UNC5A: view

Variants for UNC5A Gene

Sequence variations from dbSNP and Humsavar for UNC5A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs472176 -- 176,823,136(-) GCAGC(A/G)TCTCC intron-variant
rs475533 -- 176,878,983(-) CTGCC(A/C)AGCTC intron-variant, reference, missense
rs478253 -- 176,878,677(-) AGTGG(A/G)AGCAC intron-variant, reference, missense
rs480782 -- 176,846,369(-) CAGCT(C/T)CCCCC intron-variant
rs483868 -- 176,812,468(-) GCACA(C/G)ACATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5A Gene

Variant ID Type Subtype PubMed ID
nsv462557 CNV Loss 19166990
dgv6376n71 CNV Loss 21882294
nsv509100 CNV Insertion 20534489
dgv6377n71 CNV Loss 21882294
dgv6378n71 CNV Loss 21882294
dgv732n27 CNV Loss 19166990
esv2666951 CNV Deletion 23128226
nsv883155 CNV Loss 21882294
nsv462562 CNV Loss 19166990
esv2731180 CNV Deletion 23290073
nsv328116 CNV Loss 16902084
esv2731181 CNV Deletion 23290073
esv21826 CNV Gain 19812545
esv1663529 CNV Insertion 17803354
esv1776918 CNV Deletion 17803354
esv2731182 CNV Deletion 23290073
esv2670396 CNV Deletion 23128226
nsv513275 CNV Loss 21212237
esv1379063 CNV Deletion 17803354
esv2731183 CNV Deletion 23290073
esv1004326 CNV Deletion 20482838
esv1176499 CNV Deletion 17803354
dgv362n21 CNV Loss 19592680

Relevant External Links for UNC5A Gene

HapMap Linkage Disequilibrium report
UNC5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5A Gene

Disorders for UNC5A Gene

(1) University of Copenhagen DISEASES for UNC5A Gene

Relevant External Links for UNC5A

Genetic Association Database (GAD)
UNC5A
Human Genome Epidemiology (HuGE) Navigator
UNC5A
genes like me logo Genes that share disorders with UNC5A: view

No data available for UniProtKB/Swiss-Prot for UNC5A Gene

Publications for UNC5A Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K. … Mehlen P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. p53RDL1 regulates of p53-dependent apoptosis. (PMID: 12598906) Tanikawa C. … Arakawa H. (Nat. Cell Biol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UNC5A Gene

Sources for UNC5A Gene

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