Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC5A Gene

protein-coding   GIFtS: 61
GCID: GC05P176237

Unc-5 Homolog A (C. Elegans)

(Previous name: unc5 (C.elegans homolog) a)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Unc-5 Homolog A (C. Elegans)1 2     Netrin Receptor UNC5A2
UNC5H12 3 5     Netrin Receptor Unc5h12
Unc5 (C.Elegans Homolog) A1 2     Unc-5 Homolog 12
Protein Unc-5 Homolog 12 3     KIAA19763
Protein Unc-5 Homolog A2 3     

External Ids:    HGNC: 125671   Entrez Gene: 902492   Ensembl: ENSG000001137637   OMIM: 6078695   UniProtKB: Q6ZN443   

Export aliases for UNC5A gene to outside databases

Previous GC identifers: GC00U990540 GC05P176270 GC05P176170 GC05P171160


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UNC5A Gene:
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of
netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).(supplied by OMIM, Apr
2004)

GeneCards Summary for UNC5A Gene: 
UNC5A (unc-5 homolog A (C. elegans)) is a protein-coding gene. Diseases associated with UNC5A include kidney cancer, and colorectal cancer, and among its related super-pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Axon guidance. An important paralog of this gene is BAI1.

UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
induction when not associated with netrin ligand

Gene Wiki entry for UNC5A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC5A gene promoter:
         AP-2gamma   Arnt   Max   HSF2   AP-2beta   AP-2alpha   Zic3   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC5A promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.3

UNC5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC5A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176237:  view genomic region     (about GC identifiers)

Start:
176,237,478 bp from pter      End:
176,307,899 bp from pter
Size:
70,422 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44 (See protein sequence)
Recommended Name: Netrin receptor UNC5A precursor  
Size: 842 amino acids; 92932 Da
Subunit: Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly
mediating some interaction with PKC (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Note=The interaction
with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones
(By similarity)
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or
kidney cancers
Sequence caution: Sequence=BAB85562.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B2RXE6 Q8TF26 Q96GP4
Alternative splicing: 3 isoforms:  Q6ZN44-1   Q6ZN44-2   Q6ZN44-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNC5A: NX_Q6ZN44

Explore proteomics data for UNC5A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro (By similarity)
  • UniProtKB: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is
    associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZN44

  • UNC5A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UNC5A Protein Expression
    REFSEQ proteins: NP_588610.2  
    ENSEMBL proteins: 
     ENSP00000332737   ENSP00000424067   ENSP00000421795   ENSP00000261961  
    Reactome Protein details: Q6ZN44
    Human Recombinant Protein Products for UNC5A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UNC5A (UNC5H1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UNC5A
    OriGene Protein Over-expression Lysate for UNC5A
    OriGene MassSpec for UNC5A 
    OriGene Custom Protein Services for UNC5A
    GenScript Custom Purified and Recombinant Proteins Services for UNC5A
    Novus Biologicals UNC5A Protein
    Novus Biologicals UNC5A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UNC5A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    UNC5A for ontologies           About GeneDecksing



    UNC5A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for UNC5A (UNC5H1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UNC5A
    GenScript Custom Superior Antibodies Services for UNC5A
    Novus Biologicals UNC5A Antibodies
    Abcam antibodies for UNC5A
    Cloud-Clone Corp. Antibodies for UNC5A 
    Search ThermoFisher Antibodies for UNC5A
    LSBio Antibodies in human, mouse, rat for UNC5A 

    Assay Products for UNC5A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UNC5A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UNC5A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UNC5A 
    Cloud-Clone Corp. CLIAs for UNC5A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    5/8 InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR011029 DEATH-like_dom
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q6ZN44

    ProtoNet protein and cluster: Q6ZN44

    3 Blocks protein domains:
    IPB000488 Death domain
    IPB000884 Thrombospondin
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44
    Domain: The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis (By
    similarity)
    Similarity: Belongs to the unc-5 family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 ZU5 domain


    UNC5A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UNC5A_HUMAN, Q6ZN44
    Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the
    developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association
    with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis
    induction when not associated with netrin ligand
    Induction: By p53/TP53

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    UNC5A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UNC5A:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Unc5a):
     cellular  nervous system 

    UNC5A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UNC5A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UNC5A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UNC5A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UNC5A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5A
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5A (see all 36):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-4267 hsa-let-7g hsa-miR-4325 hsa-let-7a hsa-miR-3908 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidUNC5A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UNC5A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UNC5A
    Sirion Biotech Customized adenovirus for overexpression of UNC5A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UNC5A (see all 8)
    OriGene ORF clones in mouse, rat for UNC5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNC5A (NM_133369)
    Sino Biological Human cDNA Clone for UNC5A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5A
    Sirion Biotech Customized lentivirus for stable overexpression of UNC5A 
                         Customized lentivirus expression plasmids for stable overexpression of UNC5A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UNC5A
    Search LifeMap BioReagents cell lines for UNC5A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UNC5A About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Apoptosis0.39
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Netrin-1 signaling
    Netrin-1 signaling0.33
    4Role of DCC in regulating apoptosis
    Role of DCC in regulating apoptosis
    5Netrin mediated repulsion signals
    Netrin mediated repulsion signals

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UNC5A
        Guidance Cues and Growth Cone Motility
    Netrin Signaling


    5/7        Reactome Pathways for UNC5A (see all 7)
        Netrin mediated repulsion signals
    Regulation of Apoptosis
    Developmental Biology
    Netrin-1 signaling
    Role of DCC in regulating apoptosis


    1         Kegg Pathway  (Kegg details for UNC5A):
        Axon guidance


    UNC5A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for UNC5A (Q6ZN443 ENSP000003327374) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=2 STRING: ENSP00000364847
    NTN1O956313, ENSP000001732294I2D: score=1 STRING: ENSP00000173229
    DAPK1P533553, ENSP000003507854I2D: score=1 STRING: ENSP00000350785
    DCCENSP000003891404STRING: ENSP00000389140
    RAC1ENSP000003484614STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0007165signal transduction IEA--
    GO:0007411axon guidance TAS--
    GO:0033564anterior/posterior axon guidance IEA--
    GO:0042981regulation of apoptotic process TAS--

    UNC5A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC5A

    Search CenterWatch for drugs/clinical trials and news about UNC5A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UNC5A gene: 
    NM_133369.2  

    Unigene Cluster for UNC5A:

    Unc-5 homolog A (C. elegans)
    Hs.33191  [show with all ESTs]
    Unigene Representative Sequence: NM_133369
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329542(uc003mex.1 uc003mey.3) ENST00000513890(uc010jkg.1)
    ENST00000509580 ENST00000261961
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UNC5A
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC5A (see all 36):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-4267 hsa-let-7g hsa-miR-4325 hsa-let-7a hsa-miR-3908 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidUNC5A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UNC5A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5A
    Clone
    Products:
         
    OriGene clones in human, mouse for UNC5A (see all 8)
    OriGene ORF clones in mouse, rat for UNC5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UNC5A (NM_133369)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UNC5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5A
    Sirion Biotech Customized lentivirus for stable overexpression of UNC5A 
                         Customized lentivirus expression plasmids for stable overexpression of UNC5A 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UNC5A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UNC5A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5A

    Additional mRNA sequence: 

    AK131380.1 BC009333.2 BC033727.1 BC122556.1 BC157824.1 

    8 DOTS entries:

    DT.303017  DT.440944  DT.91996076  DT.100021845  DT.100743049  DT.99996360  DT.120818188  DT.95360734 

    24/67 AceView cDNA sequences (see all 67):

    BQ691915 CR598115 BM271771 BX282095 BU195807 BQ689148 BC009333 CK824949 
    BU729492 BI818609 BM479478 AB075856 AI951556 BG470852 BF530640 AA478265 
    BM272095 R19123 BI758231 BG329812 AA400943 BF311804 BX453456 BM668454 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5A (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                        -     -     -     -     -                           
    SP2:                    -     -                             -                                                                                                   
    SP3:                    -     -                                                                                                                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for UNC5A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC5A expression in normal human tissues (normalized intensities)      UNC5A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGCTCGT
    UNC5A Expression
    About this image


    UNC5A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Zeugopod Long Bone
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Meckel's Cartilage
             sensory organ/ear/inner ear   
     
     Neuron (Nervous System)    fully expand to see all 2 entries
             Human Neuron (HN)   
             nerve   
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   

    See UNC5A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC5A

    SOURCE GeneReport for Unigene cluster: Hs.33191
        SABiosciences Custom PCR Arrays for UNC5A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UNC5A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UNC5A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UNC5A gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc5a1 , 5 unc-5 homolog A (C. elegans)1, 5 88.28(n)1
    93.47(a)1
      13 (29.80 cM)5
    1074481  NM_153131.31  NP_694771.11 
     549494115 
    chicken
    (Gallus gallus)
    Aves UNC5A1 unc-5 homolog A (C. elegans) 80.23(n)
    80.27(a)
      426419  XM_424067.3  XP_424067.3 
    lizard
    (Anolis carolinensis)
    Reptilia UNC5A6
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343526.1(13711-45710)
    zebrafish
    (Danio rerio)
    Actinopterygii unc5a1 unc-5 homolog A (C. elegans) 70.33(n)
    68.74(a)
      799734  NM_001114465.1  NP_001107937.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta unc-56
    unc-5
    21(a)
    1 → many
    2R(11237659-11255807)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-56
    Netrin receptor unc-5
    24(a)
    1 → many
    IV(5495666-5516265)


    ENSEMBL Gene Tree for UNC5A (if available)
    TreeFam Gene Tree for UNC5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC5A gene
    BAI12  UNC5B2  UNC5CL2  UNC5C2  CFP2  BAI32  BAI22  UNC5D2  
    4 SIMAP similar genes for UNC5A using alignment to 5 protein entries:     UNC5A_HUMAN (see all proteins):
    UNC5C    UNC5B    UNC5D    CFP

    UNC5A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1823 SNPs in UNC5A are shown (see all 1823)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887535041,2
    --171158941(+) ACGTCC/TGCCTC 1 -- int10--------
    rs1495761891,2
    C--171159021(+) CTGGC-/TGTGTGT
    GTGTGTGTG
    TGTGT
    1 -- int10--------
    rs1479028361,2
    C--171159106(+) TGACCC/TCAAGC 1 -- int10--------
    rs1489663171,2
    C--176235582(+) CCAAAA/GTGCTG 1 -- us2k10--------
    rs29627791,2
    C--176235754(+) GACTCA/TCCTCT 1 -- us2k1 trp310Minor allele frequency- T:0.07WA NA CSA 252
    rs723646811,2
    C--176235839(+) TCCTA-/ACCACAC 1 -- us2k10--------
    rs1436484641,2
    C--176235926(+) GCCCCA/GAAAGC 1 -- us2k10--------
    rs1924033791,2
    --176236429(+) GGCCCC/GGTAGG 1 -- us2k10--------
    rs1510448291,2
    C--176236486(+) ACCCAA/GACTAG 1 -- us2k10--------
    rs1410845121,2
    --176236513(+) GATCAC/TTCCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC5A (176237478 - 176307899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for UNC5A (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1776918CNV Deletion17803354
    esv2731183CNV Deletion23290073
    esv1004326CNV Deletion20482838
    esv2731182CNV Deletion23290073
    esv1176499CNV Deletion17803354
    esv2670396CNV Deletion23128226
    esv2731180CNV Deletion23290073
    esv2666951CNV Deletion23128226
    esv1379063CNV Deletion17803354
    esv2731181CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC5A
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC5A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607869    OMIM disorders: --

    3 diseases for UNC5A:    About MalaCards
    kidney cancer    colorectal cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for UNC5A:
    Colorectal cancer

    UNC5A for disorders           About GeneDecksing

    Genetic Association Database (GAD): UNC5A
    Human Genome Epidemiology (HuGE) Navigator: UNC5A (3 documents)

    Export disorders for UNC5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC5A gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with UNC5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 9 Thiebault K.... Mehlen P. (2003)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. p53RDL1 regulates of p53-dependent apoptosis. (PubMed id 12598906)1, 2 Tanikawa C.... Arakawa H. (2003)
    6. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
    7. Identification of UNC5A as a novel transcriptional ta rget of tumor suppressor p53 and a regulator of apoptosis. (PubMed id 20372800)1 Miyamoto Y....Arakawa H. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PubMed id 17174565)1 Qin S....Zhang C. (2007)
    10. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. (PubMed id 15729359)1 Llambi F....Mehlen P. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90249 HGNC: 12567 AceView: UNC5A Ensembl:ENSG00000113763 euGenes: HUgn90249
    ECgene: UNC5A Kegg: 90249 H-InvDB: UNC5A

    (According to HUGE)
    About This Section
    HUGE: KIAA1976

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UNC5A gene:
    Search GeneIP for patents involving UNC5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for UNC5A (UNC5H1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for UNC5A (UNC5H1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UNC5A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UNC5A  
     OriGene MassSpec something-or-other for UNC5A   OriGene clones in human, mouse for UNC5A  
     OriGene qSTAR qPCR primer pairs in human, mouse for UNC5A   OriGene Purified Protein for UNC5A  
     OriGene ORF clones in mouse, rat for UNC5A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UNC5A   OriGene Custom Protein Services for UNC5A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UNC5A
     QIAGEN SeqTarget long-range PCR primers for resequencing UNC5A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC5A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC5A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC5A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC5A
     GenScript Custom Purified and Recombinant Proteins Services for UNC5A GenScript cDNA clones with any tag delivered in your preferred vector for UNC5A
     GenScript Custom Assay Services for UNC5A GenScript Custom Superior Antibodies Services for UNC5A
     GenScript Custom overexpressing Cell Line Services for UNC5A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UNC5A promoter
     Search Chromatin IP Primers for UNC5A
     RT2 qPCR Primer Assay in human, mouse, rat UNC5A
     GNC Network for UNC5A
     SABiosciences PCR Arrays including human, mouse, rat UNC5A
     Search Tocris compounds for UNC5A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for UNC5A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UNC5A antibodies
     UNC5A proteins
     UNC5A lysates
     Antibodies for UNC5A
     See all of Abcam's Antibodies, Kits and Proteins for UNC5A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UNC5A
     Antibodies for UNC5A
     ELISAs for UNC5A
     CLIAs for UNC5A
     Search LifeMap BioReagents cell lines for UNC5A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC5A
     SwitchGear 3'UTR luciferase reporter plasmids for UNC5A
     SwitchGear Promoter luciferase reporter plasmids for UNC5A
     Search ThermoFisher Antibodies for UNC5A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC5A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UNC5A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UNC5A
    Customized:
     lentivirus for stable overexpression of UNC5A
     lentivirus expression plasmids for stable overexpression of UNC5A
     adenovirus for overexpression of UNC5A
     LSBio Antibodies in human, mouse, rat for UNC5A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UNC5A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4