Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UNC50 Gene

Aliases for UNC50 Gene

  • Unc-50 Inner Nuclear Membrane RNA Binding Protein 2
  • Unc-50 Homolog (C. Elegans) 2 3 5
  • Periodontal Ligament-Specific Protein 22 3 4
  • Uncoordinated-Like Protein 3 4
  • Protein GMH1 Homolog 3 4
  • PDLs22 3 4
  • HGMH1 3 4
  • UNCL 3 4
  • Geal-6 Membrane-Associated High-Copy Suppressor 1 3
  • Unc-50-Like Protein 3
  • Unc-50 Related 3
  • HSD23 3
  • GMH1 3
  • URP 3

External Ids for UNC50 Gene

Previous GeneCards Identifiers for UNC50 Gene

  • GC02P098846
  • GC02P098683
  • GC02P099225
  • GC02P092989

Summaries for UNC50 Gene

GeneCards Summary for UNC50 Gene

UNC50 (Unc-50 Inner Nuclear Membrane RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for UNC50 Gene

  • May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC50 Gene

Genomics for UNC50 Gene

Regulatory Elements for UNC50 Gene

Enhancers for UNC50 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UNC50 on UCSC Golden Path with GeneCards custom track

Promoters for UNC50 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UNC50 on UCSC Golden Path with GeneCards custom track

Genomic Location for UNC50 Gene

98,608,579 bp from pter
98,618,515 bp from pter
9,937 bases
Plus strand

Genomic View for UNC50 Gene

Genes around UNC50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC50 Gene

Proteins for UNC50 Gene

  • Protein details for UNC50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein unc-50 homolog
    Protein Accession:
    Secondary Accessions:
    • D3DVH4
    • Q53S98
    • Q53TD6
    • Q5U5U2
    • Q6X7B9
    • Q9UQF4
    • Q9Y4S6

    Protein attributes for UNC50 Gene

    259 amino acids
    Molecular mass:
    30373 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UNC50 Gene

Proteomics data for UNC50 Gene at MOPED

Post-translational modifications for UNC50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC50 Gene

No data available for DME Specific Peptides for UNC50 Gene

Domains & Families for UNC50 Gene

Protein Domains for UNC50 Gene


Suggested Antigen Peptide Sequences for UNC50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the unc-50 family.
  • Belongs to the unc-50 family.
genes like me logo Genes that share domains with UNC50: view

No data available for Gene Families for UNC50 Gene

Function for UNC50 Gene

Molecular function for UNC50 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity).

Phenotypes for UNC50 Gene

GenomeRNAi human phenotypes for UNC50:
genes like me logo Genes that share phenotypes with UNC50: view

Animal Model Products

CRISPR Products

miRNA for UNC50 Gene

miRTarBase miRNAs that target UNC50

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC50 Gene

Localization for UNC50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC50 Gene

Nucleus inner membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for UNC50 Gene COMPARTMENTS Subcellular localization image for UNC50 gene
Compartment Confidence
golgi apparatus 4
nucleus 3
plasma membrane 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UNC50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC50: view

Pathways & Interactions for UNC50 Gene

SuperPathways for UNC50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UNC50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with UNC50: view

No data available for Pathways by source and SIGNOR curated interactions for UNC50 Gene

Drugs & Compounds for UNC50 Gene

No Compound Related Data Available

Transcripts for UNC50 Gene

Unigene Clusters for UNC50 Gene

Unc-50 homolog (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC50 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - -

Relevant External Links for UNC50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNC50 Gene

mRNA expression in normal human tissues for UNC50 Gene

Protein differential expression in normal tissues from HIPED for UNC50 Gene

This gene is overexpressed in Pancreas (49.8) and Testis (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UNC50 Gene

SOURCE GeneReport for Unigene cluster for UNC50 Gene Hs.13370

mRNA Expression by UniProt/SwissProt for UNC50 Gene

Tissue specificity: Present in periodontal ligament fibroblasts (at protein level).
genes like me logo Genes that share expression patterns with UNC50: view

Protein tissue co-expression partners for UNC50 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UNC50 Gene

Orthologs for UNC50 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UNC50 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UNC50 35
  • 89.32 (n)
  • 97.68 (a)
UNC50 36
  • 97 (a)
(Canis familiaris)
Mammalia UNC50 35
  • 92.28 (n)
  • 98.84 (a)
(Mus musculus)
Mammalia Unc50 35
  • 86.62 (n)
  • 95.75 (a)
Unc50 16
Unc50 36
  • 96 (a)
(Pan troglodytes)
Mammalia UNC50 35
  • 99.87 (n)
  • 100 (a)
UNC50 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Unc50 35
  • 87.39 (n)
  • 96.14 (a)
(Monodelphis domestica)
Mammalia UNC50 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia UNC50 36
  • 76 (a)
(Gallus gallus)
Aves UNC50 35
  • 77.86 (n)
  • 86.1 (a)
UNC50 36
  • 86 (a)
(Anolis carolinensis)
Reptilia UNC50 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16401 35
unc50 35
  • 76.71 (n)
  • 83.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32171 35
(Danio rerio)
Actinopterygii unc50 35
  • 73.02 (n)
  • 80.16 (a)
zgc56114 35
unc50 36
  • 80 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10827 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002901 35
  • 58.96 (n)
  • 58.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9773 35
  • 56.73 (n)
  • 54.9 (a)
CG9773 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea unc-50 35
  • 53.78 (n)
  • 49 (a)
unc-50 36
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR073C 35
  • 46.88 (n)
  • 38.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21230g 35
  • 47.18 (n)
  • 38.81 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GMH1 35
  • 48.4 (n)
  • 38.8 (a)
GMH1 36
  • 35 (a)
GMH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G15240 35
  • 49.64 (n)
  • 39.91 (a)
(Oryza sativa)
Liliopsida Os09g0109500 35
  • 49.72 (n)
  • 42.15 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.650 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug16 35
  • 52.78 (n)
  • 47.06 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5619 36
  • 53 (a)
Species with no ortholog for UNC50:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC50 Gene

Gene Tree for UNC50 (if available)
Gene Tree for UNC50 (if available)

Paralogs for UNC50 Gene

No data available for Paralogs for UNC50 Gene

Variants for UNC50 Gene

Sequence variations from dbSNP and Humsavar for UNC50 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3769698 -- 98,617,431(-) AATTC(A/G)TTAGA intron-variant
rs3820941 -- 98,617,318(-) GAACC(A/G)GGGTG intron-variant
rs3835895 -- 98,617,563(-) TATAG(-/G)AAGTT intron-variant
rs14841 -- 98,618,383(-) TGATA(A/G)TTTAT utr-variant-3-prime
rs11885661 -- 98,615,954(+) CTTTA(C/T)GACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC50 Gene

Variant ID Type Subtype PubMed ID
esv2585417 CNV Deletion 19546169

Variation tolerance for UNC50 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.44; 77.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UNC50 Gene

Disorders for UNC50 Gene

Relevant External Links for UNC50

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UNC50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC50 Gene

Publications for UNC50 Gene

  1. UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein. (PMID: 10980252) Fitzgerald J. … Forsayeth J.R. (Brain Res. 2000) 2 3 4 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. UNC50 prompts G1/S transition and proliferation in HCC by regulation of epidermal growth factor receptor trafficking. (PMID: 25738771) Fang Z. … Yu L. (PLoS ONE 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for UNC50 Gene

Sources for UNC50 Gene