UNC50 Gene
protein-coding GIFtS : 48
GCID: GC02 P099225
unc-50 homolog (C. elegans)
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Aliasesfor UNC50 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Unc-50 Homolog (C. Elegans) 1 2 Uncoordinated-Like Protein2 3 UNCL1 2 3 PDLs222 3 GMH11 2 HGMH11 URP1 2 Geal-6 Membrane-Associated High-Copy Suppressor 12 Periodontal Ligament-Specific Protein 222 3 Protein Unc-50 Homolog2 Protein GMH1 Homolog2 3 Unc-50 Related2
Export aliases for UNC50 gene to outside databases Previous GC identifers: GC02P098846 GC02P098683 GC02P098591 GC02P092989
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Summariesfor UNC50 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: UNC50_HUMAN, Q53HI1 Function : May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity)
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Genomic Viewsfor UNC50 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022171.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UNC50 gene promoter: HFH-3 AML1a CUTL1 C/EBPalpha FOXI1 HFH-1 HSF2 Meis-1a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for UNC50 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat UNC50
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q12.2 UNC50 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P099225: view genomic region
(about GC identifiers )
Start:
99,225,042 bp from pter
End:
99,234,978 bp from pter
Size:
9,937 bases
Orientation:
plus strand
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Proteinsfor UNC50 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: UNC50_HUMAN, Q53HI1 (See
protein sequence )Recommended Name: Protein unc-50 homolog Size : 259 amino acids; 30373 Da
Subcellular location : Nucleus inner membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane;Multi-pass membrane protein
Secondary accessions : D3DVH4 Q53S98 Q53TD6 Q5U5U2 Q6X7B9 Q9UQF4 Q9Y4S6Explore the universe of human proteins at neXtProt for UNC50: NX_Q53HI1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q53HI1 UNC50 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_054763.2 ENSEMBL proteins: ENSP00000350409 ENSP00000387146 ENSP00000386466 ENSP00000377131 ENSP00000412224 Human Recombinant Protein Products for UNC50: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
UNC50 for ontologies About GeneDecksing UNC50 Antibody Products: Assay Products for UNC50:
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Protein
Domains / Familiesfor UNC50 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
UNC50 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q53HI1 ProtoNet protein and cluster: Q53HI1
UniProtKB/Swiss-Prot: UNC50_HUMAN, Q53HI1 Similarity : Belongs to the unc-50 family
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Functionfor UNC50 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: UNC50_HUMAN, Q53HI1 Function : May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity)
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003723 RNA binding
IEA --
UNC50 for ontologies About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UNC50 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UNC50OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UNC50 (NM_014044 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UNC50 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UNC50
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC50
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Pathways & Interactionsfor UNC50 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UNC50 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)5/21 Interacting proteins for UNC50 (Q53HI1 2 , 3 ENSP00000350409 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 21 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007166 cell surface receptor signaling pathway
IEA -- GO:0015031 protein transport
IEA --
UNC50 for ontologies About GeneDecksing
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Drugs & Compoundsfor UNC50 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for UNC50 Search CenterWatch for drugs/clinical trials and news about UNC50
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Transcriptsfor UNC50 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for UNC50 gene: NM_014044.5 Unigene Cluster for UNC50:
Unc-50 homolog (C. elegans) Hs.13370 [show with all ESTs ] Unigene Representative Sequence: BC039078 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000357765 (uc002szc.4 ) ENST00000409975 (uc002szb.3 ) ENST00000409347 (uc010yvl.2 )ENST00000393493 ENST00000423713 ENST00000466492 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UNC50 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UNC50OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UNC50 (NM_014044 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UNC50 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UNC50
Additional cDNA sequence: AF077038.1 AK222599.1 AL080115.1 AY017215.1 AY251534.1 BC017019.1 BC025992.2 BC039078.1 BC091481.1 CR533464.1
14 DOTS entries : DT.95275339 DT.101959823
DT.97845731 DT.417379 DT.100026828 DT.100648116 DT.205425 DT.120936114 DT.91720581 DT.120936099 DT.95275336 DT.120936053 DT.120936089 DT.95275337 24/203 AceView cDNA sequences (see all 203 ):
BM693612 BI830201 Z43792 W86144 CK906209 AA463457 BF513083 BU620989 BM982656 NM_014044 BC017019 BI822850 BM724228 AA281853 AA937950 BI789153 BM669198 BM551002 AW028063 AF077038 CD106636 AW079830 AI309195 AI276170 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UNC50 (see all 6 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b SP1 :       -   -       -   -   -         SP2 :       -         -             SP3 :       -   -       -             SP4 :       -   -                   SP5 :                          
ECgene alternative splicing isoforms for UNC50
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Expression for UNC50 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section UNC50 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTATCCTGACAbout this image UNC50 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See UNC50 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UNC50 SOURCE GeneReport for Unigene cluster: Hs.13370 UniProtKB/Swiss-Prot: UNC50_HUMAN, Q53HI1 Tissue specificity : Present in periodontal ligament fibroblasts (at protein level) SABiosciences Custom PCR Arrays for UNC50 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for UNC50Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat UNC50 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat UNC50 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat UNC50 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC50
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Orthologsfor UNC50 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for UNC50 gene from 10/34 species (see all 34 ) About this table
ENSEMBL Gene Tree for UNC50 (if available)TreeFam Gene Tree for UNC50 (if available)
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Paralogsfor UNC50 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor UNC50 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for UNC50 (99225042 - 99234978 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for UNC50 1 CNV : 97919
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor UNC50 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
UNC50 for disorders About GeneDecksing 2 diseases for UNC50 : About MalaCards periodontitis neuronitis Export disorders for UNC50 gene to outside databases
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Publicationsfor UNC50 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for UNC50 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with UNC50) Utopia : connect your pdf to the dynamic world of online information
UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein. (PubMed id 10980252) 1 , 2 , 3 Fitzgerald J.... Forsayeth J.R. (2000) Expression of UNCL during development of periodontal tissue and response of periodontal ligament fibroblasts to mechanical stress in vivo and in vitro. (PubMed id 17004066) 1 , 2 Kim H.-J.... Park J.-C. (2007) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 Wiemann S.... Poustka A. (2001) Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152) 1 , 2 Zhang Q.-H.... Chen Z. (2000) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p. (PubMed id 12808035) 2 Chantalat S.... Peyroche A. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for UNC50 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing UNC50 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing UNC50 gene
(According to HUGE )
About This Section --
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Specialized Databases showing UNC50 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for UNC50 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for UNC50 gene: Search GeneIP for patents involving UNC50 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor UNC50 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for UNC50 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for UNC50 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for UNC50 OriGene Protein Over-expression Lysate for UNC50 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for UNC50 OriGene 3'-UTR Clone for UNC50 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UNC50 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UNC50 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for UNC50 OriGene Custom Protein Services for UNC50 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UNC50 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNC50 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat UNC50 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat UNC50 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat UNC50 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat UNC50
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UNC50 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC50
ThermoFisher Antibodies for UNC50
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UNC50
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