Aliases for UNC45B Gene
External Ids for UNC45B Gene
Previous HGNC Symbols for UNC45B Gene
Previous GeneCards Identifiers for UNC45B Gene
This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for UNC45B Gene
UNC45B (Unc-45 Myosin Chaperone B) is a Protein Coding gene. Diseases associated with UNC45B include cataract 43 and nuclear cataract. GO annotations related to this gene include binding and Hsp90 protein binding. An important paralog of this gene is SPAG1.
UniProtKB/Swiss-Prot for UNC45B Gene
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.