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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC45B Gene

protein-coding   GIFtS: 49
GCID: GC17P033474

unc-45 homolog B (C. elegans)

(Previous name: cardiomyopathy associated 4 )
(Previous symbol: CMYA4)
 Explore 1 disease affiliated with
UNC45B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UNC45B    

Aliases
for UNC45B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Unc-45 Homolog B (C. Elegans)1 2     UNC-45B2
CMYA41 2 3     Protein Unc-45 Homolog B2
UNC451 2 3     Striated Muscle UNC452
Cardiomyopathy Associated 41 2     Unc-45B3
SMUNC452 3     

External Ids:    HGNC: 143041   Entrez Gene: 1468622   Ensembl: ENSG000001411617   OMIM: 6112205   UniProtKB: Q8IWX73   

Export aliases for UNC45B gene to outside databases

Previous GC identifers: GC17P030500 GC17P029659


Summaries
for UNC45B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UNC45B:
UNC45B plays a role in myoblast fusion and sarcomere organization (Price et al., 2002 (PubMed 12356907)).(supplied by
OMIM, Mar 2008)

UniProtKB/Swiss-Prot: UN45B_HUMAN, Q8IWX7
Function: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role
in sarcomere formation during muscle cell development (By similarity)




Genomic Views
for UNC45B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC45B gene promoter:
         CREB   SREBP-1a   p53   SREBP-1c   deltaCREB   Nkx2-5   SREBP-1b   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UNC45B promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC45B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC45B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

UNC45B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC45B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P033474:  view genomic region     (about GC identifiers)

Start:
 33,474,836 bp from pter      End:
 33,516,364 bp from pter
Size:
 41,529 bases      Orientation:
 plus strand

Proteins
for UNC45B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UN45B_HUMAN, Q8IWX7 (See protein sequence)
Recommended Name: Protein unc-45 homolog B  
Size: 931 amino acids; 103733 Da
Subunit: Interacts with HSP90 in an ATP-independent manner (By similarity)
Subcellular location: Cytoplasm, cytosol (By similarity)
Secondary accessions: Q495Q8 Q495Q9
Alternative splicing: 3 isoforms:  Q8IWX7-1   Q8IWX7-2   Q8IWX7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UNC45B: NX_Q8IWX7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IWX7

    • UNC45B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028748.1  NP_001253981.1  NP_775259.1  

    ENSEMBL proteins: 
     ENSP00000268876   ENSP00000378071   ENSP00000468335   ENSP00000412840   ENSP00000367710  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UNC45B

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--


    UNC45B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for UNC45B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UNC45B for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR011989 ARM-like
     IPR024660 UNC-45/Ring3
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8IWX7

    ProtoNet protein and cluster: Q8IWX7

    1 Blocks protein family: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: UN45B_HUMAN, Q8IWX7
    Similarity: Contains 3 ARM repeats
    Similarity: Contains 3 TPR repeats


    Function
    for UNC45B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UN45B_HUMAN, Q8IWX7
    Function: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role
    in sarcomere formation during muscle cell development (By similarity)

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC45B (see all 15):
    hsa-miR-362-3p hsa-miR-1236 hsa-miR-4306 hsa-miR-944 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-3672 hsa-miR-329
    SwitchGear 3'UTR luciferase reporter plasmid: UNC45B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051879Hsp90 protein binding IEA--


    UNC45B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UNC45B:
     Increased circadian period len 


    Pathways & Interactions
    for UNC45B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UNC45B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for UNC45B (Q8IWX73 ENSP000002688764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PEX19P408553I2D: score=4 
    HSP90AB1ENSP000003258754STRING: ENSP00000325875
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development IEA--
    GO:0030154cell differentiation IEA--
    GO:0061077chaperone-mediated protein folding IEA--


    UNC45B for ontologies           About GeneDecksing



    Drugs & Compounds
    for UNC45B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC45B
    Search CenterWatch for drugs/clinical trials and news about UNC45B / UN45B 

    Transcripts
    for UNC45B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UNC45B gene (3 alternative transcripts): 
    NM_001033576.1  NM_001267052.1  NM_173167.2  

    Unigene Cluster for UNC45B:

    Unc-45 homolog B (C. elegans)
    Hs.379636  [show with all ESTs]
    Unigene Representative Sequence: NM_173167
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268876 ENST00000394570(uc002hja.3 uc002hjb.3 uc002hjc.3 uc010cto.3)
    ENST00000591048 ENST00000433649 ENST00000378449

    miRNA
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    hsa-miR-362-3p hsa-miR-1236 hsa-miR-4306 hsa-miR-944 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-3672 hsa-miR-329
    SwitchGear 3'UTR luciferase reporter plasmid: UNC45B 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF539794.1 AK095929.1 AL832355.1 AL833281.1 BC101062.2 BC101063.2 BX647642.1 

    2 DOTS entries:

    DT.436822  DT.100018844 

    24/26 AceView cDNA sequences (see all 26):

    BM697527 AA404417 AI014875 AF539794 AI572463 AK095929 NM_173167 BU735725 
    AW755253 F16124 AI800785 BF790722 AL832355 AA452197 AA249623 AI246442 
    AL833281 BX647642 AA216015 AA780099 AI472849 AA780204 AA211338 AJ708042 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC45B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    


    ECgene alternative splicing isoforms for UNC45B

    Expression
    for UNC45B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC45B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGGCCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UNC45B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cardiomyocyte-like progenitor cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UNC45B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC45B

    SOURCE GeneReport for Unigene cluster: Hs.379636
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    In Situ
    Assay Products:     
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    Orthologs
    for UNC45B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UNC45B gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UNC45B1 unc-45 homolog B (C. elegans) 75.78(n)
    82.13(a)    		   417527  XM_415774.3  XP_415774.3 
    lizard
    (Anolis carolinensis)    		 Reptilia UNC45B6
    		 --
    		 79(a)
    		 1 ↔ 1
    		 AAWZ02040345(615-5788)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.112792 Transcribed sequence with weak similarity to protein more 75.4(n)    CF783972.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii unc45r2 unc-45 (C. elegans) related 76.04(n)   266640  AF330001.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta unc-451 CG2708-PA 49.16(n)
    35.6(a)    		   44910  NM_080057.3  NP_524796.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-451 Protein UNC-45 45.02(n)
    33.08(a)    		   175206  NM_064804.4  NP_497205.1 


    ENSEMBL Gene Tree for UNC45B (if available)
    TreeFam Gene Tree for UNC45B (if available) 

    Paralogs
    for UNC45B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC45B gene
    UNC45A2  
    1 SIMAP similar gene for UNC45B using alignment to 2 protein entries:     UN45B_HUMAN (see all proteins):
    UNC45A

    UNC45B for paralogs           About GeneDecksing



    Genomic Variants
    for UNC45B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/889 NCBI SNPs in UNC45B are shown (see all 889)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1412139941,2
    		--33472842(+) CATAGA/TCACAA 3 -- us2k10--------
    rs1507084151,2
    		--33472911(+) AGAAAC/TGTGGG 3 -- us2k10--------
    rs1145814471,2
    		F,--33472917(+) GTGGGC/TCAGGC 3 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1379084491,2
    		--33472925(+) GGCGCA/GGTGGC 3 -- us2k10--------
    rs1494702971,2
    		--33473086(+) GCTACC/TCATGA 3 -- us2k10--------
    rs1472145301,2
    		--33473089(+) ACTCAC/TGAGGC 3 -- us2k10--------
    rs1850814551,2
    		--33473110(+) GAATCG/TCTTGA 3 -- us2k10--------
    rs1150340481,2
    		F,--33473221(+) CAAAAA/GGATGT 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs753254141,2
    		F,--33473318(+) GCCAAT/CGTCAG 3 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1406379141,2
    		--33473367(+) GCCCCA/GCAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC45B (33474836 - 33516364 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UNC45B: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNC45B
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC45B

    Disorders / Diseases
    for UNC45B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UNC45B for disorders           About GeneDecksing

    OMIM gene information: 611220    OMIM disorders: --

    1 disease for UNC45B:    About MalaCards
    cardiomyopathy

    Human Genome Epidemiology (HuGE) Navigator: UNC45B (1 document)

    Export disorders for UNC45B gene to outside databases

    Publications
    for UNC45B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC45B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with UNC45B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. (PubMed id 12356907)1, 2, 3 Price M.G.... Epstein H.F. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for UNC45B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing UNC45B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146862 HGNC: 14304 AceView: CMYA4 Ensembl:ENSG00000141161 euGenes: HUgn146862
    ECgene: UNC45B H-InvDB: UNC45B

    Other Databases showing UNC45B gene

    (According to HUGE)
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    Specialized Databases showing UNC45B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC45B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    		Patent Information for UNC45B gene:
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