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Aliases for UNC45B Gene

Aliases for UNC45B Gene

  • Unc-45 Homolog B (C. Elegans) 2 3
  • Cardiomyopathy Associated 4 2 3
  • UNC-45B 3 4
  • SMUNC45 3 4
  • CMYA4 3 4
  • UNC45 3 4
  • Protein Unc-45 Homolog B 3
  • Striated Muscle UNC45 3
  • CTRCT43 3

External Ids for UNC45B Gene

Previous HGNC Symbols for UNC45B Gene

  • CMYA4

Previous GeneCards Identifiers for UNC45B Gene

  • GC17P030500
  • GC17P033474
  • GC17P029659

Summaries for UNC45B Gene

Entrez Gene Summary for UNC45B Gene

  • UNC45B plays a role in myoblast fusion and sarcomere organization (Price et al., 2002 [PubMed 12356907]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UNC45B Gene

UNC45B (Unc-45 Homolog B (C. Elegans)) is a Protein Coding gene. Diseases associated with UNC45B include nuclear cataract. GO annotations related to this gene include Hsp90 protein binding. An important paralog of this gene is SPAG1.

UniProtKB/Swiss-Prot for UNC45B Gene

  • Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC45B Gene

Genomics for UNC45B Gene

Regulatory Elements for UNC45B Gene

Genomic Location for UNC45B Gene

Start:
35,147,794 bp from pter
End:
35,189,345 bp from pter
Size:
41,552 bases
Orientation:
Plus strand

Genomic View for UNC45B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNC45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC45B Gene

Proteins for UNC45B Gene

  • Protein details for UNC45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWX7-UN45B_HUMAN
    Recommended name:
    Protein unc-45 homolog B
    Protein Accession:
    Q8IWX7
    Secondary Accessions:
    • Q495Q8
    • Q495Q9

    Protein attributes for UNC45B Gene

    Size:
    931 amino acids
    Molecular mass:
    103733 Da
    Quaternary structure:
    • Interacts with HSP90 in an ATP-independent manner.

    Alternative splice isoforms for UNC45B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC45B Gene

Proteomics data for UNC45B Gene at MOPED

Post-translational modifications for UNC45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC45B Gene

No data available for DME Specific Peptides for UNC45B Gene

Domains for UNC45B Gene

Protein Domains for UNC45B Gene

Suggested Antigen Peptide Sequences for UNC45B Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWX7

UniProtKB/Swiss-Prot:

UN45B_HUMAN :
  • Q8IWX7
Similarity:
  • Contains 3 ARM repeats.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with UNC45B: view

No data available for Gene Families for UNC45B Gene

Function for UNC45B Gene

Molecular function for UNC45B Gene

UniProtKB/Swiss-Prot Function: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (By similarity).

Gene Ontology (GO) - Molecular Function for UNC45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25036637
GO:0051879 Hsp90 protein binding IEA --
genes like me logo Genes that share ontologies with UNC45B: view

Phenotypes for UNC45B Gene

GenomeRNAi human phenotypes for UNC45B:
genes like me logo Genes that share phenotypes with UNC45B: view

Animal Model Products

CRISPR Products

miRNA for UNC45B Gene

miRTarBase miRNAs that target UNC45B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UNC45B Gene

Localization for UNC45B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC45B Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC45B Gene COMPARTMENTS Subcellular localization image for UNC45B gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UNC45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with UNC45B: view

Pathways for UNC45B Gene

SuperPathways for UNC45B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UNC45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development IEA --
GO:0030154 cell differentiation IEA --
GO:0061077 chaperone-mediated protein folding IEA --
genes like me logo Genes that share ontologies with UNC45B: view

No data available for Pathways by source for UNC45B Gene

Transcripts for UNC45B Gene

Unigene Clusters for UNC45B Gene

Unc-45 homolog B (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNC45B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UNC45B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC45B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:

Relevant External Links for UNC45B Gene

GeneLoc Exon Structure for
UNC45B
ECgene alternative splicing isoforms for
UNC45B

Expression for UNC45B Gene

mRNA expression in normal human tissues for UNC45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC45B Gene

This gene is overexpressed in Muscle - Skeletal (21.6), Heart - Left Ventricle (18.5), and Heart - Atrial Appendage (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UNC45B Gene

SOURCE GeneReport for Unigene cluster for UNC45B Gene Hs.379636

genes like me logo Genes that share expressions with UNC45B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UNC45B Gene

Orthologs for UNC45B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UNC45B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC45B 35
  • 99.21 (n)
  • 99.14 (a)
UNC45B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC45B 35
  • 89.99 (n)
  • 94.08 (a)
UNC45B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC45B 35
  • 91.53 (n)
  • 96.99 (a)
UNC45B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc45b 35
  • 88.77 (n)
  • 95.05 (a)
Unc45b 16
Unc45b 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNC45B 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Unc45b 35
  • 87.83 (n)
  • 94.14 (a)
chicken
(Gallus gallus)
Aves UNC45B 35
  • 75.82 (n)
  • 82.05 (a)
UNC45B 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11279 35
unc45b 35
  • 70.38 (n)
  • 78.14 (a)
zebrafish
(Danio rerio)
Actinopterygii unc45b 35
  • 69.29 (n)
  • 71.77 (a)
unc45b 36
  • 71 (a)
OneToOne
unc45r 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003727 35
  • 51.42 (n)
  • 38.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta unc-45 35
  • 49.16 (n)
  • 35.6 (a)
unc-45 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-45 35
  • 45.03 (n)
  • 33.22 (a)
unc-45 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 36
  • 14 (a)
ManyToMany
TOM71 36
  • 13 (a)
ManyToMany
Species with no ortholog for UNC45B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC45B Gene

ENSEMBL:
Gene Tree for UNC45B (if available)
TreeFam:
Gene Tree for UNC45B (if available)

Paralogs for UNC45B Gene

Paralogs for UNC45B Gene

Selected SIMAP similar genes for UNC45B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UNC45B: view

Variants for UNC45B Gene

Sequence variations from dbSNP and Humsavar for UNC45B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11439 -- 35,188,145(+) CCTAC(A/C)TTTTA utr-variant-3-prime
rs883070 -- 35,165,064(-) AAACA(G/T)AGCAA intron-variant
rs922667 -- 35,186,004(+) GCATG(A/T)TTTAG intron-variant
rs964725 -- 35,184,518(+) CAGGT(C/T)CTCAC intron-variant
rs1351577 -- 35,159,008(-) AATTT(A/G)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC45B Gene

Variant ID Type Subtype PubMed ID
nsv2037 CNV Loss 18451855

Relevant External Links for UNC45B Gene

HapMap Linkage Disequilibrium report
UNC45B
Human Gene Mutation Database (HGMD)
UNC45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC45B Gene

Disorders for UNC45B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UNC45B Gene including...

Search for UNC45B Gene in MalaCards »

Relevant External Links for UNC45B

Genetic Association Database (GAD)
UNC45B
Human Genome Epidemiology (HuGE) Navigator
UNC45B
genes like me logo Genes that share disorders with UNC45B: view

No data available for UniProtKB/Swiss-Prot for UNC45B Gene

Publications for UNC45B Gene

  1. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. (PMID: 12356907) Price M.G. … Epstein H.F. (J. Cell Sci. 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PMID: 22751105) Chu L. … Tomasson M.H. (J. Clin. Invest. 2012) 3
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3

Products for UNC45B Gene

Sources for UNC45B Gene

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