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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC45A Gene

protein-coding   GIFtS: 51
GCID: GC15P091473

unc-45 homolog A (C. elegans)
 Explore 7 diseases affiliated with
UNC45A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UNC45A    

Aliases
for UNC45A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Unc-45 Homolog A (C. Elegans)1 2     IRO0397002
SMAP-11 2 3     UNC-45A2
SMAP12 3 5     General Cell UNC452
GC-UNC451 2     Protein Unc-45 Homolog A2
Smooth Muscle Cell-Associated Protein 12 3     Smooth Muscle Cell Associated Protein-12
GCUNC-452 3     Unc-45A3
GCUNC452 5     

External Ids:    HGNC: 305941   Entrez Gene: 558982   Ensembl: ENSG000001405537   OMIM: 6112195   UniProtKB: Q9H3U13   

Export aliases for UNC45A gene to outside databases

Previous GC identifers: GC15P089275 GC15P067584


Summaries
for UNC45A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UNC45A:
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90
(HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002
(PubMed 12356907); Chadli et al., 2006 (PubMed 16478993)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
Function: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive
factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for
normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell
development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)

Gene Wiki entry for UNC45A


Genomic Views
for UNC45A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC45A gene promoter:
         E2F-3a   E2F-1   E2F   Hand1   E2F-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UNC45A promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC45A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC45A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

UNC45A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC45A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091473:  view genomic region     (about GC identifiers)

Start:
 91,471,728 bp from pter      End:
 91,497,323 bp from pter
Size:
 25,596 bases      Orientation:
 plus strand

Proteins
for UNC45A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1 (See protein sequence)
Recommended Name: Protein unc-45 homolog A  
Size: 944 amino acids; 103077 Da
Subunit: Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding
to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear region.
Little protein in the nucleus
1 PDB 3D structure from and Proteopedia for UNC45A:
2DBA (3D)    
Secondary accessions: A8K6F7 Q7L3Y6 Q9H3U8 Q9NSE8 Q9NSE9
Alternative splicing: 3 isoforms:  Q9H3U1-1   Q9H3U1-2   Q9H3U1-3   

Explore the universe of human proteins at neXtProt for UNC45A: NX_Q9H3U1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H3U1

    • UNC45A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034764.1  NP_061141.2  

    ENSEMBL proteins: 
     ENSP00000377816   ENSP00000407487  

    Human Recombinant Protein Products: 
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    Novus Biologicals UNC45A Protein
    Novus Biologicals UNC45A Lysates
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    Uscn Proteins for UNC45A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0048471perinuclear region of cytoplasm IEA--


    UNC45A for ontologies           About GeneDecksing



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    Uscn Antibodies for UNC45A
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    Uscn ELISAs and CLIAs for UNC45A

    Protein Domains /
    Families
    for UNC45A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UNC45A for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011990 TPR-like_helical
     IPR011989 ARM-like
     IPR013105 TPR_2
     IPR024660 UNC-45/Ring3
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H3U1

    ProtoNet protein and cluster: Q9H3U1

    1 Blocks protein family: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
    Similarity: Contains 3 TPR repeats


    Function
    for UNC45A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
    Function: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive
    factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for
    normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell
    development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: UNC45A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051879Hsp90 protein binding IEA--


    UNC45A for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for UNC45A:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 


    Pathways & Interactions
    for UNC45A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC45A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/755 Interacting proteins for UNC45A (Q9H3U12, 3 ENSP000004074874) via UniProtKB, MINT, STRING, and/or I2D (see all 755)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62148 I2D: score=3 
    ILKQ134182, 3MINT-7945693 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    HSP90AA1P079002, 3, ENSP000003351534MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000335153
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development IEA--
    GO:0030154cell differentiation IEA--
    GO:0061077chaperone-mediated protein folding IEA--


    UNC45A for ontologies           About GeneDecksing



    Drugs & Compounds
    for UNC45A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC45A
    Search CenterWatch for drugs/clinical trials and news about UNC45A / UN45A 

    Transcripts
    for UNC45A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UNC45A gene (3 alternative transcripts): 
    NM_017979.1  NM_001039675.1  NM_018671.3  

    Unigene Cluster for UNC45A:

    Unc-45 homolog A (C. elegans)
    Hs.389461  [show with all ESTs]
    Unigene Representative Sequence: NM_001039675
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553358 ENST00000480470 ENST00000461266 ENST00000394275(uc002bqd.3 uc010uqo.1 uc010uqp.1 uc002bqg.3)
    ENST00000556319 ENST00000495068 ENST00000497152 ENST00000553671 ENST00000557212(uc010uqq.1)
    ENST00000418476 ENST00000486253 ENST00000556482 ENST00000556704 ENST00000554481
    ENST00000487875(uc010uqr.2) ENST00000471780(uc021suj.1)

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC45A:
    hsa-miR-485-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-3129-5p hsa-miR-4316 hsa-miR-144 hsa-miR-101
    SwitchGear 3'UTR luciferase reporter plasmid: UNC45A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC45A (see all 6)
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC45A 
    Primer
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    Additional cDNA sequence: 

    AB014729.1 AB014736.1 AK125523.1 AK125721.1 AK128480.1 AK291622.1 AK293538.1 AK296964.1 
    AK302979.1 AL357532.1 AL357537.1 AL357538.1 BC006214.1 BC010995.2 BC037992.1 BC045635.1 

    24/27 DOTS entries (see all 27):

    DT.95215459  DT.95148320  DT.121032588  DT.100812968  DT.95148332  DT.100812970  DT.102839904  DT.121032554 
    DT.99969076  DT.121032577  DT.100812981  DT.100812974  DT.92446525  DT.121032563  DT.121032580  DT.121032596 
    DT.121032597  DT.121032609  DT.40256273  DT.95148314  DT.100036151  DT.100812972  DT.121032598  DT.121032608 

    24/307 AceView cDNA sequences (see all 307):

    CB267774 BQ888509 AL039213 BU628966 BQ028852 CA438514 BC010995 BC045635 
    BQ682861 AB014736 AI148197 AK125721 AL045976 CD250879 AI492116 BU849086 
    Z42819 BU931565 BQ437098 BU154112 BG751602 BM723470 BU157901 AA476965 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for UNC45A (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^
    SP1:                                      -     -                                         -                                   -                       -         
    SP2:                                                                                                                                                            
    SP3:                    -                 -     -                                                                                                               
    SP4:                    -                 -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
    SP1:                    -                                             
    SP2:                    -                                             
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for UNC45A

    Expression
    for UNC45A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC45A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCAATACTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UNC45A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Floor PlateSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UNC45A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC45A

    SOURCE GeneReport for Unigene cluster: Hs.389461

    UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
    Tissue specificity: Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid,
    lymph node and stomach

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    In Situ
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    Orthologs
    for UNC45A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UNC45A gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Unc45a1 , 5 unc-45 homolog A (C. elegans)1, 5 88.84(n)1
    94.07(a)1    		   7 (45.65 cM)5
    1018691  NM_133952.21  NP_598713.21 
     803252925 
    chicken
    (Gallus gallus)    		 Aves UNC45A1 unc-45 homolog A (C. elegans) 75.07(n)
    75.33(a)    		   415584  XM_003641836.1  XP_003641884.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UNC45A6
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343759.1(58690-72529)
    zebrafish
    (Danio rerio)    		 Actinopterygii unc45a6
    		 unc-45 homolog A (C. elegans)
    		 65(a)
    		 1 ↔ 1
    		 25(8826203-8888596)
    fruit fly
    (Drosophila melanogaster)    		 Insecta unc-456
    		 --
    		 35(a)
    		 1 → many
    		 3R(3859027-3862374)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-456
    		 UNCoordinated family member (unc-45)
    		 32(a)
    		 possible ortholog
    		 III(491545-502148)


    ENSEMBL Gene Tree for UNC45A (if available)
    TreeFam Gene Tree for UNC45A (if available) 

    Paralogs
    for UNC45A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC45A gene
    UNC45B2  
    1 SIMAP similar gene for UNC45A using alignment to 1 protein entry:     UN45A_HUMAN:
    UNC45B

    UNC45A for paralogs           About GeneDecksing



    Genomic Variants
    for UNC45A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/556 NCBI SNPs in UNC45A are shown (see all 556)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1866528581,2
    		--91471506(+) GAGCCA/GAGATT 1 -- us2k10--------
    rs573744301,2
    		--91471544(+) AGAGCA/GAGAAT 1 -- us2k10--------
    rs1484863201,2
    		--91471590(+) CATTTA/CCTGTT 1 -- us2k10--------
    rs1914477271,2
    		--91471633(+) CTTTCA/GCAATT 1 -- us2k10--------
    rs1829183741,2
    		--91471642(+) TTTGGA/GTTAAT 1 -- us2k10--------
    rs595593931,2
    		C--91471680(+) AAAAA-/AATAGAA 1 -- us2k11Minor allele frequency- AA:0.00NA 2
    rs1860794841,2
    		--91471828(+) GAGCAC/TGGGGG 1 -- us2k10--------
    rs1426606971,2
    		--91472024(+) AACTAA/GAATTC 1 -- us2k10--------
    rs1908863871,2
    		--91472028(+) AAAATG/TCTAGA 1 -- us2k10--------
    rs71730691,2
    		C,F,A,H,--91472046(+) ATTGTG/TAAGAG 1 -- us2k119Minor allele frequency- T:0.10NS EA NA WA CSA 1937

    HapMap Linkage Disequilibrium report for UNC45A (91471728 - 91497323 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for UNC45A
         2 CNVs: 49620 4909

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    Disorders / Diseases
    for UNC45A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UNC45A for disorders           About GeneDecksing

    OMIM gene information: 611219    OMIM disorders: --

    7 diseases for UNC45A:    About MalaCards
    diamond-blackfan anemia    arteriovenous malformation    cystadenoma    ovarian cancer
    breast cancer    anemia    thyroiditis


    Export disorders for UNC45A gene to outside databases

    Publications
    for UNC45A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC45A gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with UNC45A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. (PubMed id 16478993)1, 2 Chadli A.... Toft D. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. (PubMed id 12356907)1, 3 Price M.G.... Epstein H.F. (2002)
    5. Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. (PubMed id 17872978)1, 9 Bazzaro M....Roden R.B. (2007)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for UNC45A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UNC45A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55898 HGNC: 30594 AceView: SMAP-1 Ensembl:ENSG00000140553 euGenes: HUgn55898
    ECgene: UNC45A H-InvDB: UNC45A

    Other Databases showing UNC45A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UNC45A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC45A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UNC45A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UNC45A gene:
    Search GeneIP for patents involving UNC45A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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