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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC45A Gene

protein-coding   GIFtS: 52
GCID: GC15P091473

Unc-45 Homolog A (C. Elegans)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Unc-45 Homolog A (C. Elegans)1 2     GC-UNC452
SMAP12 3 5     IRO0397002
Smooth Muscle Cell Associated Protein-11 2     UNC-45A2
Smooth Muscle Cell-Associated Protein 12 3     General Cell UNC452
GCUNC-452 3     Protein Unc-45 Homolog A2
SMAP-12 3     Unc-45A3
GCUNC452 5     

External Ids:    HGNC: 305941   Entrez Gene: 558982   Ensembl: ENSG000001405537   OMIM: 6112195   UniProtKB: Q9H3U13   

Export aliases for UNC45A gene to outside databases

Previous GC identifers: GC15P089275 GC15P067584


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UNC45A Gene:
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and
HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et
al., 2002 (PubMed 12356907); Chadli et al., 2006 (PubMed 16478993)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UNC45A Gene: 
UNC45A (unc-45 homolog A (C. elegans)) is a protein-coding gene. Diseases associated with UNC45A include arteriovenous malformation, and diamond-blackfan anemia. GO annotations related to this gene include Hsp90 protein binding. An important paralog of this gene is TOMM70A.

UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
Function: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive
factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential).
Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during
muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)

Gene Wiki entry for UNC45A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC45A gene promoter:
         E2F-3a   E2F-1   E2F   Hand1   E2F-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC45A promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC45A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC45A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

UNC45A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC45A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091473:  view genomic region     (about GC identifiers)

Start:
91,473,410 bp from pter      End:
91,497,323 bp from pter
Size:
23,914 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1 (See protein sequence)
Recommended Name: Protein unc-45 homolog A  
Size: 944 amino acids; 103077 Da
Subunit: Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1.
Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear
region. Little protein in the nucleus
1 PDB 3D structure from and Proteopedia for UNC45A:
2DBA (3D)    
Secondary accessions: A8K6F7 Q7L3Y6 Q9H3U8 Q9NSE8 Q9NSE9
Alternative splicing: 3 isoforms:  Q9H3U1-1   Q9H3U1-2   Q9H3U1-3   

Explore the universe of human proteins at neXtProt for UNC45A: NX_Q9H3U1

Explore proteomics data for UNC45A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H3U1

  • UNC45A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UNC45A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001034764.1  NP_061141.2  

    ENSEMBL proteins: 
     ENSP00000377816   ENSP00000407487  

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    Cloud-Clone Corp. Proteins for UNC45A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    UNC45A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR011989 ARM-like
     IPR013105 TPR_2
     IPR024660 UNC-45/Ring3
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H3U1

    ProtoNet protein and cluster: Q9H3U1

    1 Blocks protein domain: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
    Similarity: Contains 3 TPR repeats


    UNC45A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UN45A_HUMAN, Q9H3U1
    Function: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive
    factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential).
    Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during
    muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0051879Hsp90 protein binding IEA--
         
    UNC45A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UNC45A:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidUNC45A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC45A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/792 Interacting proteins for UNC45A (Q9H3U12, 3 ENSP000004074874) via UniProtKB, MINT, STRING, and/or I2D (see all 792)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62148 I2D: score=3 
    ILKQ134182, 3MINT-7945693 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    HSP90AA1P079002, 3, ENSP000003351534MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000335153
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development IEA--
    GO:0030154cell differentiation IEA--
    GO:0061077chaperone-mediated protein folding IEA--

    UNC45A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC45A (UN45A)

    Search CenterWatch for drugs/clinical trials and news about UNC45A / UN45A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UNC45A gene (3 alternative transcripts): 
    NM_017979.1  NM_001039675.1  NM_018671.3  

    Unigene Cluster for UNC45A:

    Unc-45 homolog A (C. elegans)
    Hs.389461  [show with all ESTs]
    Unigene Representative Sequence: NM_001039675
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480470 ENST00000461266 ENST00000394275(uc002bqd.3 uc010uqo.1 uc010uqp.1 uc002bqg.3)
    ENST00000556319 ENST00000495068 ENST00000497152 ENST00000553671 ENST00000557212(uc010uqq.1)
    ENST00000418476 ENST00000486253 ENST00000556482 ENST00000556704 ENST00000554481
    ENST00000487875(uc010uqr.2) ENST00000471780(uc021suj.1)
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC45A:
    hsa-miR-485-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-3129-5p hsa-miR-4316 hsa-miR-144 hsa-miR-101
    SwitchGear 3'UTR luciferase reporter plasmidUNC45A 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UNC45A
    Sirion Biotech Customized lentivirus for stable overexpression of UNC45A 
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    Additional mRNA sequence: 

    AB014729.1 AB014736.1 AK125523.1 AK125721.1 AK128480.1 AK291622.1 AK293538.1 AK296964.1 
    AK302979.1 AL357532.1 AL357537.1 AL357538.1 BC006214.1 BC010995.2 BC037992.1 BC045635.1 

    24/27 DOTS entries (see all 27):

    DT.95215459  DT.95148320  DT.121032588  DT.100812968  DT.95148332  DT.100812970  DT.102839904  DT.121032554 
    DT.99969076  DT.121032577  DT.100812981  DT.100812974  DT.92446525  DT.121032563  DT.121032580  DT.121032596 
    DT.121032597  DT.121032609  DT.40256273  DT.95148314  DT.100036151  DT.100812972  DT.121032598  DT.121032608 

    24/307 AceView cDNA sequences (see all 307):

    CD250879 BQ686804 BU931169 AI924835 BQ071204 BQ682170 Z42819 BQ876806 
    AL045976 BQ069408 AA022947 AI148197 BQ681068 BU154112 BG751602 BC010995 
    CB306323 BC006214 BM723470 BG170735 AA405786 AI299916 BQ888509 AB014729 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for UNC45A (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^
    SP1:                                      -     -                                         -                                   -                       -         
    SP2:                                                                                                                                                            
    SP3:                    -                 -     -                                                                                                               
    SP4:                    -                 -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
    SP1:                    -                                             
    SP2:                    -                                             
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for UNC45A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC45A expression in normal human tissues (normalized intensities)      UNC45A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAATACTC
    UNC45A Expression
    About this image


    UNC45A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
             mouse/organ system/cardiovascular system   
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme   

    See UNC45A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC45A

    SOURCE GeneReport for Unigene cluster: Hs.389461

    UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
    Tissue specificity: Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord,
    thyroid, lymph node and stomach

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC45A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UNC45A gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc45a1 , 5 unc-45 homolog A (C. elegans)1, 5 88.84(n)1
    94.07(a)1
      7 (45.65 cM)5
    1018691  NM_133952.21  NP_598713.21 
     803252925 
    chicken
    (Gallus gallus)
    Aves UNC45A1 unc-45 homolog A (C. elegans) 75.07(n)
    75.33(a)
      415584  XM_003641836.1  XP_003641884.1 
    lizard
    (Anolis carolinensis)
    Reptilia UNC45A6
    UNC45B6
    Uncharacterized protein
    66(a)
    59(a)
    1 ↔ 1
    possible ortholog
    GL343759.1(58399-72706)
    AAWZ02040345(454-7035)
    zebrafish
    (Danio rerio)
    Actinopterygii unc45a6
    unc-45 homolog A (C. elegans)
    65(a)
    1 ↔ 1
    25(8826203-8888596)
    fruit fly
    (Drosophila melanogaster)
    Insecta unc-456
    --
    35(a)
    1 → many
    3R(3859027-3862374)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-456
    Protein UNC-45
    32(a)
    1 → many
    III(491547-502150)


    ENSEMBL Gene Tree for UNC45A (if available)
    TreeFam Gene Tree for UNC45A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC45A gene
    TOMM70A2  TTC12  UNC45B2  
    1 SIMAP similar gene for UNC45A using alignment to 1 protein entry:     UN45A_HUMAN:
    UNC45B

    UNC45A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/604 SNPs in UNC45A are shown (see all 604)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0526294
    ----see VAR_0526292 T M mis40--------
    rs1866528581,2
    --91471506(+) GAGCCA/GAGATT 1 -- us2k10--------
    rs573744301,2
    --91471544(+) AGAGCA/GAGAAT 1 -- us2k10--------
    rs1484863201,2
    --91471590(+) CATTTA/CCTGTT 1 -- us2k10--------
    rs1914477271,2
    --91471633(+) CTTTCA/GCAATT 1 -- us2k10--------
    rs1829183741,2
    --91471642(+) TTTGGA/GTTAAT 1 -- us2k10--------
    rs340069561,2
    C--91471680(+) AAAAA-/A/AA  
            
    TAGAA
    1 -- us2k12NA CSA 4
    rs595593931,2
    C--91471680(+) AAAAA-/AATAGAA 1 -- us2k11Minor allele frequency- AA:0.00NA 2
    rs1860794841,2
    --91471828(+) GAGCAC/TGGGGG 1 -- us2k10--------
    rs1426606971,2
    C--91472024(+) AACTAA/GAATTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC45A (91473410 - 91497323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UNC45A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833089CNV Loss17160897
    nsv515661CNV Loss19592680
    nsv833090CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC45A
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC45A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611219    OMIM disorders: --

    7 diseases for UNC45A:    About MalaCards
    arteriovenous malformation    diamond-blackfan anemia    cystadenoma    anemia
    ovarian cancer    thyroiditis    breast cancer


    UNC45A for disorders           About GeneDecksing


    Export disorders for UNC45A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC45A gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with UNC45A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. (PubMed id 16478993)1, 2 Chadli A.... Toft D. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. (PubMed id 12356907)1, 3 Price M.G.... Epstein H.F. (2002)
    5. Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. (PubMed id 17872978)1, 9 Bazzaro M....Roden R.B. (2007)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55898 HGNC: 30594 AceView: SMAP-1 Ensembl:ENSG00000140553 euGenes: HUgn55898
    ECgene: UNC45A H-InvDB: UNC45A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC45A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UNC45A gene:
    Search GeneIP for patents involving UNC45A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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