Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UNC45A Gene

Aliases for UNC45A Gene

  • Unc-45 Myosin Chaperone A 2 3 5
  • Smooth Muscle Cell Associated Protein-1 2 3
  • GCUNC-45 3 4
  • UNC-45A 3 4
  • SMAP-1 3 4
  • SMAP1 3 4
  • Smooth Muscle Cell-Associated Protein 1 4
  • Unc-45 Homolog A (C. Elegans) 2
  • Protein Unc-45 Homolog A 3
  • General Cell UNC45 3
  • Unc-45 Homolog A 3
  • IRO039700 3
  • GC-UNC45 3
  • GCUNC45 3

External Ids for UNC45A Gene

Previous GeneCards Identifiers for UNC45A Gene

  • GC15P089275
  • GC15P091473
  • GC15P067584

Summaries for UNC45A Gene

Entrez Gene Summary for UNC45A Gene

  • UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UNC45A Gene

UNC45A (Unc-45 Myosin Chaperone A) is a Protein Coding gene. GO annotations related to this gene include binding and Hsp90 protein binding. An important paralog of this gene is UNC45B.

UniProtKB/Swiss-Prot for UNC45A Gene

  • Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).

Gene Wiki entry for UNC45A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC45A Gene

Genomics for UNC45A Gene

Regulatory Elements for UNC45A Gene

Enhancers for UNC45A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F090949 0.5 ENCODE 16.6 +19.8 19775 1.3 ATF1 BACH1 ZNF316 GATA2 NFE2 CREM MAFK NFE2L2 ZNF639 SMAD5 UNC45A PRC1 MAN2A2 RCCD1 GC15P090938
GH15F090928 0.5 ENCODE 15.8 +0.9 866 4.6 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RCCD1 UNC45A MAN2A2 FES HDDC3
GH15F090958 0.2 ENCODE 15.8 +30.0 30021 2.8 ZNF362 SCRT2 KLF9 ZNF600 RCCD1 UNC45A MAN2A2 LOC101926911 NDUFA3P4 ENSG00000258384 PRC1-AS1
GH15F090934 0.5 ENCODE 15.4 +5.4 5421 3.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF766 ZNF143 DEK SP3 RCCD1 UNC45A MAN2A2 ENSG00000224441 GC15P090938
GH15F090914 0.9 Ensembl ENCODE 15.4 -14.5 -14508 3.0 HDAC1 PKNOX1 CBX3 TBL1XR1 RAD21 FOS CREM HCFC1 ZBTB11 USF2 UNC45A MAN2A2 GC15M090902 PIR58181
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UNC45A on UCSC Golden Path with GeneCards custom track

Promoters for UNC45A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001798115 92 1401 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SP3 REST

Genomic Location for UNC45A Gene

Chromosome:
15
Start:
90,930,008 bp from pter
End:
90,954,093 bp from pter
Size:
24,086 bases
Orientation:
Plus strand

Genomic View for UNC45A Gene

Genes around UNC45A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC45A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC45A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC45A Gene

Proteins for UNC45A Gene

  • Protein details for UNC45A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3U1-UN45A_HUMAN
    Recommended name:
    Protein unc-45 homolog A
    Protein Accession:
    Q9H3U1
    Secondary Accessions:
    • A8K6F7
    • Q7L3Y6
    • Q9H3U8
    • Q9NSE8
    • Q9NSE9

    Protein attributes for UNC45A Gene

    Size:
    944 amino acids
    Molecular mass:
    103077 Da
    Quaternary structure:
    • Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.

    Three dimensional structures from OCA and Proteopedia for UNC45A Gene

    Alternative splice isoforms for UNC45A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC45A Gene

Post-translational modifications for UNC45A Gene

  • Ubiquitination at Lys 142, Lys 190, Lys 329, Lys 411, and Lys 707
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for UNC45A

No data available for DME Specific Peptides for UNC45A Gene

Domains & Families for UNC45A Gene

Suggested Antigen Peptide Sequences for UNC45A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3U1

UniProtKB/Swiss-Prot:

UN45A_HUMAN :
  • Contains 3 TPR repeats.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with UNC45A: view

No data available for Gene Families for UNC45A Gene

Function for UNC45A Gene

Molecular function for UNC45A Gene

UniProtKB/Swiss-Prot Function:
Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).

Gene Ontology (GO) - Molecular Function for UNC45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0051879 Hsp90 protein binding IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with UNC45A: view
genes like me logo Genes that share phenotypes with UNC45A: view

Animal Models for UNC45A Gene

MGI Knock Outs for UNC45A:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC45A Gene

Localization for UNC45A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC45A Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear region. Little protein in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC45A Gene COMPARTMENTS Subcellular localization image for UNC45A gene
Compartment Confidence
cytosol 4
nucleus 4
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UNC45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with UNC45A: view

Pathways & Interactions for UNC45A Gene

SuperPathways for UNC45A Gene

No Data Available

Gene Ontology (GO) - Biological Process for UNC45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
GO:0030154 cell differentiation IEA --
GO:0061077 chaperone-mediated protein folding IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with UNC45A: view

No data available for Pathways by source and SIGNOR curated interactions for UNC45A Gene

Transcripts for UNC45A Gene

Unigene Clusters for UNC45A Gene

Unc-45 homolog A (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC45A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^
SP1: - - - - -
SP2:
SP3: - - -
SP4: - - -
SP5:
SP6: - - - -
SP7: - - - -
SP8: - - - -
SP9:
SP10: -
SP11:
SP12: -
SP13:

ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for UNC45A Gene

GeneLoc Exon Structure for
UNC45A
ECgene alternative splicing isoforms for
UNC45A

Expression for UNC45A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UNC45A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC45A Gene

This gene is overexpressed in Bone (42.4) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UNC45A Gene



Protein tissue co-expression partners for UNC45A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNC45A Gene:

UNC45A

SOURCE GeneReport for Unigene cluster for UNC45A Gene:

Hs.389461

mRNA Expression by UniProt/SwissProt for UNC45A Gene:

Q9H3U1-UN45A_HUMAN
Tissue specificity: Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach.
genes like me logo Genes that share expression patterns with UNC45A: view

Primer Products

No data available for mRNA differential expression in normal tissues for UNC45A Gene

Orthologs for UNC45A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UNC45A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC45A 34 35
  • 95.15 (n)
cow
(Bos Taurus)
Mammalia UNC45A 34 35
  • 91.04 (n)
dog
(Canis familiaris)
Mammalia UNC45A 34 35
  • 90.32 (n)
rat
(Rattus norvegicus)
Mammalia Unc45a 34
  • 89.05 (n)
mouse
(Mus musculus)
Mammalia Unc45a 34 16 35
  • 88.84 (n)
oppossum
(Monodelphis domestica)
Mammalia UNC45A 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC45A 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC45A 34 35
  • 74.92 (n)
lizard
(Anolis carolinensis)
Reptilia UNC45A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc45a 34
  • 67.85 (n)
zebrafish
(Danio rerio)
Actinopterygii unc45a 35
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-45 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-45 35
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 35
  • 16 (a)
ManyToMany
TOM71 35
  • 13 (a)
ManyToMany
Species where no ortholog for UNC45A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC45A Gene

ENSEMBL:
Gene Tree for UNC45A (if available)
TreeFam:
Gene Tree for UNC45A (if available)

Paralogs for UNC45A Gene

Paralogs for UNC45A Gene

(1) SIMAP similar genes for UNC45A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNC45A: view

Variants for UNC45A Gene

Sequence variations from dbSNP and Humsavar for UNC45A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10459678 -- 90,947,567(+) TCCAG(C/T)GGCCA intron-variant
rs1052528 -- 90,931,065(-) CATTT(C/T)TGATG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1052532 -- 90,931,006(-) GTGGG(A/G)TCTCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1052535 -- 90,931,508(-) TCATT(C/G)CATCA intron-variant, utr-variant-3-prime
rs10635983 -- 90,947,976(+) CCTCC(-/CT)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC45A Gene

Variant ID Type Subtype PubMed ID
nsv515661 CNV loss 19592680
nsv833089 CNV loss 17160897
nsv833090 CNV loss 17160897

Variation tolerance for UNC45A Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC45A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC45A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC45A Gene

Disorders for UNC45A Gene

Relevant External Links for UNC45A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC45A

No disorders were found for UNC45A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC45A Gene

Publications for UNC45A Gene

  1. UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation. (PMID: 25444911) Jilani Y. … Chadli A. (Cancer Lett. 2015) 2 3 64
  2. UCS proteins: chaperones for myosin and co-chaperones for Hsp90. (PMID: 25487020) Ni W. … Odunuga O.O. (Subcell. Biochem. 2015) 2 3 64
  3. Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. (PMID: 17872978) Bazzaro M. … Roden R.B. (Am. J. Pathol. 2007) 3 22 64
  4. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. (PMID: 16478993) Chadli A. … Toft D. (Mol. Cell. Biol. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for UNC45A Gene

Sources for UNC45A Gene

Content
Loading form....