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UNC45A Gene

protein-coding   GIFtS: 53
GCID: GC15P091473

Unc-45 Homolog A (C. Elegans)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-45 Homolog A (C. Elegans)1 2     IRO0397002
SMAP12 3 5     UNC-45A2
Smooth Muscle Cell Associated Protein-11 2     General Cell UNC452
GCUNC-452 3     Protein Unc-45 Homolog A2
SMAP-12 3     Unc-45A3
GCUNC452 5     Smooth Muscle Cell-Associated Protein 13
GC-UNC452     

External Ids:    HGNC: 305941   Entrez Gene: 558982   Ensembl: ENSG000001405537   OMIM: 6112195   UniProtKB: Q9H3U13   

Export aliases for UNC45A gene to outside databases

Previous GC identifers: GC15P089275 GC15P067584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UNC45A Gene:
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and
HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et
al., 2002 (PubMed 12356907); Chadli et al., 2006 (PubMed 16478993)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UNC45A Gene:
UNC45A (unc-45 homolog A (C. elegans)) is a protein-coding gene. Diseases associated with UNC45A include arteriovenous malformation, and diamond-blackfan anemia. GO annotations related to this gene include Hsp90 protein binding. An important paralog of this gene is TOMM70A.

UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
Function: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive
factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential).
Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during
muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)

Gene Wiki entry for UNC45A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UNC45A gene promoter:
         E2F-3a   E2F-1   E2F   Hand1   E2F-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUNC45A promoter sequence
   Search Chromatin IP Primers for UNC45A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UNC45A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

UNC45A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC45A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091473:  view genomic region     (about GC identifiers)

Start:
91,473,410 bp from pter      End:
91,497,323 bp from pter
Size:
23,914 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1 (See protein sequence)
Recommended Name: Protein unc-45 homolog A  
Size: 944 amino acids; 103077 Da
Subunit: Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1.
Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer
1 PDB 3D structure from and Proteopedia for UNC45A:
2DBA (3D)    
Secondary accessions: A8K6F7 Q7L3Y6 Q9H3U8 Q9NSE8 Q9NSE9
Alternative splicing: 3 isoforms:  Q9H3U1-1   Q9H3U1-2   Q9H3U1-3   

Explore the universe of human proteins at neXtProt for UNC45A: NX_Q9H3U1

Explore proteomics data for UNC45A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys142, Lys190, Lys329, Lys411, Lys707
  • Modification sites at PhosphoSitePlus

  • See UNC45A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034764.1  NP_061141.2  

    ENSEMBL proteins: 
     ENSP00000377816   ENSP00000407487  

    UNC45A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for UNC45A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR011989 ARM-like
     IPR024660 UNC-45/Ring3
     IPR013105 TPR_2
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H3U1

    ProtoNet protein and cluster: Q9H3U1

    1 Blocks protein domain: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
    Similarity: Contains 3 TPR repeats


    UNC45A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UN45A_HUMAN, Q9H3U1
    Function: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive
    factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential).
    Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during
    muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0051879Hsp90 protein binding IEA--
         
    UNC45A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UNC45A:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target UNC45A:
    hsa-mir-106b-5p (MIRT044266), hsa-mir-93-5p (MIRT048871), hsa-mir-940 (MIRT036617), hsa-mir-23b-3p (MIRT046354), hsa-mir-93-3p (MIRT038832), hsa-mir-1 (MIRT023949), hsa-mir-125a-5p (MIRT045768)

    Block miRNA regulation of human, mouse, rat UNC45A using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate UNC45A:
    hsa-miR-485-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-3129-5p hsa-miR-4316 hsa-miR-144 hsa-miR-101
    SwitchGear 3'UTR luciferase reporter plasmidUNC45A 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC45A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UN45A_HUMAN, Q9H3U1: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear
    region. Little protein in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    golgi apparatus3
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0048471perinuclear region of cytoplasm IEA--

    UNC45A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UNC45A
    Interactions:

        GeneGlobe Interaction Network for UNC45A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UNC45A (Q9H3U12, 3 ENSP000004074874) via UniProtKB, MINT, STRING, and/or I2D (see all 839)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134182, 3, ENSP000002994214MINT-7945693 I2D: score=1 STRING: ENSP00000299421
    SMAD9O151982, 3MINT-62148 I2D: score=3 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    HSP90AA1P079002, 3, ENSP000003351534MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000335153
    ACTR2P611602, ENSP000003672204MINT-7945693 MINT-7947479 STRING: ENSP00000367220
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development IEA--
    GO:0030154cell differentiation IEA--
    GO:0061077chaperone-mediated protein folding IEA--

    UNC45A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UNC45A (UN45A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UNC45A gene (3 alternative transcripts): 
    NM_017979.1  NM_001039675.1  NM_018671.3  

    Unigene Cluster for UNC45A:

    Unc-45 homolog A (C. elegans)
    Hs.389461  [show with all ESTs]
    Unigene Representative Sequence: NM_001039675
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480470 ENST00000461266 ENST00000394275(uc002bqd.3 uc010uqo.1 uc010uqp.1 uc002bqg.3)
    ENST00000556319 ENST00000495068 ENST00000497152 ENST00000553671 ENST00000557212(uc010uqq.1)
    ENST00000418476 ENST00000486253 ENST00000556482 ENST00000556704 ENST00000554481
    ENST00000487875(uc010uqr.2) ENST00000471780(uc021suj.1)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate UNC45A:
    hsa-miR-485-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-3129-5p hsa-miR-4316 hsa-miR-144 hsa-miR-101
    SwitchGear 3'UTR luciferase reporter plasmidUNC45A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): UNC45A (NM_018671)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat UNC45A
      QuantiFast Probe-based Assays in human, mouse, rat UNC45A

    Additional mRNA sequence: 

    AB014729.1 AB014736.1 AK125523.1 AK125721.1 AK128480.1 AK291622.1 AK293538.1 AK296964.1 
    AK302979.1 AL357532.1 AL357537.1 AL357538.1 BC006214.1 BC010995.2 BC037992.1 BC045635.1 

    Selected DOTS entries (see all 27):

    DT.95215459  DT.95148320  DT.121032588  DT.100812968  DT.95148332  DT.100812970  DT.102839904  DT.121032554 
    DT.99969076  DT.121032577  DT.100812981  DT.100812974  DT.92446525  DT.121032563  DT.121032580  DT.121032596 
    DT.121032597  DT.121032609  DT.40256273  DT.95148314  DT.100036151  DT.100812972  DT.121032598  DT.121032608 

    Selected AceView cDNA sequences (see all 307):

    CD251170 CO245316 BI908356 BU849086 BU846476 BE867610 BQ437098 BQ071204 
    BQ682861 AI924835 BU931169 AK125523 CA438514 AK125721 BU931616 BQ888509 
    CD251217 AL357537 BX457394 AK000905 CR624111 BQ686804 BQ069408 BQ028852 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UNC45A (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^
    SP1:                                      -     -                                         -                                   -                       -         
    SP2:                                                                                                                                                            
    SP3:                    -                 -     -                                                                                                               
    SP4:                    -                 -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
    SP1:                    -                                             
    SP2:                    -                                             
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for UNC45A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UNC45A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAATACTC
    UNC45A Expression
    About this image


    UNC45A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Umbilical Cord (Extraembryonic Tissues)
    UNC45A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UNC45A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389461

    UniProtKB/Swiss-Prot: UN45A_HUMAN, Q9H3U1
    Tissue specificity: Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord,
    thyroid, lymph node and stomach

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC45A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UNC45A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Unc45a1 , 5 unc-45 homolog A (C. elegans)1, 5 88.84(n)1
    94.07(a)1
      7 (45.65 cM)5
    1018691  NM_133952.21  NP_598713.21 
     803252925 
    chicken
    (Gallus gallus)
    Aves UNC45A1 unc-45 homolog A (C. elegans) 74.92(n)
    75.03(a)
      415584  XM_003641836.2  XP_003641884.2 
    lizard
    (Anolis carolinensis)
    Reptilia UNC45A6
    unc-45 homolog A (C. elegans)
    67(a)
    1 ↔ 1
    GL343759.1(58399-72706)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia unc45a1 unc-45 homolog A 67.85(n)
    71.64(a)
      493552  NM_001008189.1  NP_001008190.1 
    zebrafish
    (Danio rerio)
    Actinopterygii unc45a6
    unc-45 homolog A (C. elegans)
    65(a)
    1 ↔ 1
    25(8826203-8888596) ENSDARG00000003546
    fruit fly
    (Drosophila melanogaster)
    Insecta unc-456
    --
    35(a)
    1 → many
    3R(3859027-3862374)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-456
    Protein UNC-45 (unc-45) mRNA, complete cds
    32(a)
    1 → many
    III(491547-502591) WBGene00006781
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOM706
    TOM716
    Component of the TOM (translocase of outer membran...
    Mitochondrial outer membrane protein with similari...
    16(a)
    13(a)
    many ↔ many
    many ↔ many
    XIV(398684-400537) YNL121C
    VIII(342349-344268) YHR117W


    ENSEMBL Gene Tree for UNC45A (if available)
    TreeFam Gene Tree for UNC45A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UNC45A gene
    TOMM70A2  TTC12  TOMM342  SPAG12  UNC45B2  
    1 SIMAP similar gene for UNC45A using alignment to 1 protein entry:     UN45A_HUMAN:
    UNC45B

    UNC45A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UNC45A (see all 604)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866528581,2
    --91471506(+) GAGCCA/GAGATT 1 -- us2k10--------
    rs573744301,2
    --91471544(+) AGAGCA/GAGAAT 1 -- us2k10--------
    rs1484863201,2
    --91471590(+) CATTTA/CCTGTT 1 -- us2k10--------
    rs1914477271,2
    --91471633(+) CTTTCA/GCAATT 1 -- us2k10--------
    rs1829183741,2
    --91471642(+) TTTGGA/GTTAAT 1 -- us2k10--------
    rs340069561,2
    C--91471680(+) AAAAA-/A/AA  
            
    TAGAA
    1 -- us2k12NA CSA 4
    rs595593931,2
    C--91471680(+) AAAAA-/AATAGAA 1 -- us2k11Minor allele frequency- AA:0.00NA 2
    rs1860794841,2
    --91471828(+) GAGCAC/TGGGGG 1 -- us2k10--------
    rs1426606971,2
    C--91472024(+) AACTAA/GAATTC 1 -- us2k10--------
    rs1908863871,2
    --91472028(+) AAAATG/TCTAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UNC45A (91473410 - 91497323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UNC45A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833089CNV Loss17160897
    nsv515661CNV Loss19592680
    nsv833090CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UNC45A
    DNA2.0 Custom Variant and Variant Library Synthesis for UNC45A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611219    OMIM disorders: --

    6 diseases for UNC45A:    
    About MalaCards
    arteriovenous malformation    diamond-blackfan anemia    cystadenoma    ovarian cancer
    thyroiditis    breast cancer


    UNC45A for disorders           About GeneDecksing


    Export disorders for UNC45A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UNC45A gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with UNC45A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. (PubMed id 16478993)1, 2 Chadli A.... Toft D. (Mol. Cell. Biol. 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. (PubMed id 12356907)1, 3 Price M.G.... Epstein H.F. (J. Cell Sci. 2002)
    5. Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. (PubMed id 17872978)1, 9 Bazzaro M....Roden R.B. (Am. J. Pathol. 2007)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55898 HGNC: 30594 AceView: SMAP-1 Ensembl:ENSG00000140553 euGenes: HUgn55898
    ECgene: UNC45A H-InvDB: UNC45A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UNC45A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UNC45A gene:
    Search GeneIP for patents involving UNC45A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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