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Aliases for UNC45A Gene

Aliases for UNC45A Gene

  • Unc-45 Myosin Chaperone A 2 3 5
  • Smooth Muscle Cell Associated Protein-1 2 3
  • GCUNC-45 3 4
  • UNC-45A 3 4
  • SMAP-1 3 4
  • SMAP1 3 4
  • Smooth Muscle Cell-Associated Protein 1 4
  • Unc-45 Homolog A (C. Elegans) 2
  • General Cell UNC45 3
  • Unc-45 Homolog A 3
  • IRO039700 3
  • GC-UNC45 3
  • GCUNC45 3

External Ids for UNC45A Gene

Previous GeneCards Identifiers for UNC45A Gene

  • GC15P089275
  • GC15P091473
  • GC15P067584

Summaries for UNC45A Gene

Entrez Gene Summary for UNC45A Gene

  • UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UNC45A Gene

UNC45A (Unc-45 Myosin Chaperone A) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include binding and Hsp90 protein binding. An important paralog of this gene is TTC1.

UniProtKB/Swiss-Prot for UNC45A Gene

  • Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).

Gene Wiki entry for UNC45A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC45A Gene

Genomics for UNC45A Gene

Regulatory Elements for UNC45A Gene

Promoters for UNC45A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UNC45A on UCSC Golden Path with GeneCards custom track

Genomic Location for UNC45A Gene

Chromosome:
15
Start:
90,930,008 bp from pter
End:
90,954,093 bp from pter
Size:
24,086 bases
Orientation:
Plus strand

Genomic View for UNC45A Gene

Genes around UNC45A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC45A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC45A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC45A Gene

Proteins for UNC45A Gene

  • Protein details for UNC45A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3U1-UN45A_HUMAN
    Recommended name:
    Protein unc-45 homolog A
    Protein Accession:
    Q9H3U1
    Secondary Accessions:
    • A8K6F7
    • Q7L3Y6
    • Q9H3U8
    • Q9NSE8
    • Q9NSE9

    Protein attributes for UNC45A Gene

    Size:
    944 amino acids
    Molecular mass:
    103077 Da
    Quaternary structure:
    • Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.

    Three dimensional structures from OCA and Proteopedia for UNC45A Gene

    Alternative splice isoforms for UNC45A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC45A Gene

Proteomics data for UNC45A Gene at MOPED

Post-translational modifications for UNC45A Gene

  • Ubiquitination at Lys 142, Lys 190, Lys 329, Lys 411, and Lys 707
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC45A Gene

No data available for DME Specific Peptides for UNC45A Gene

Domains & Families for UNC45A Gene

Suggested Antigen Peptide Sequences for UNC45A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3U1

UniProtKB/Swiss-Prot:

UN45A_HUMAN :
  • Contains 3 TPR repeats.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with UNC45A: view

No data available for Gene Families for UNC45A Gene

Function for UNC45A Gene

Molecular function for UNC45A Gene

UniProtKB/Swiss-Prot Function:
Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).
genes like me logo Genes that share phenotypes with UNC45A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC45A Gene

Localization for UNC45A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC45A Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear region. Little protein in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC45A Gene COMPARTMENTS Subcellular localization image for UNC45A gene
Compartment Confidence
cytosol 4
nucleus 4
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for UNC45A Gene

Pathways & Interactions for UNC45A Gene

SuperPathways for UNC45A Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with UNC45A: view

Pathways by source for UNC45A Gene

1 KEGG pathway for UNC45A Gene

Gene Ontology (GO) - Biological Process for UNC45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061077 chaperone-mediated protein folding IEA --
genes like me logo Genes that share ontologies with UNC45A: view

No data available for SIGNOR curated interactions for UNC45A Gene

Drugs & Compounds for UNC45A Gene

No Compound Related Data Available

Transcripts for UNC45A Gene

Unigene Clusters for UNC45A Gene

Unc-45 homolog A (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC45A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^
SP1: - - - - -
SP2:
SP3: - - -
SP4: - - -
SP5:
SP6: - - - -
SP7: - - - -
SP8: - - - -
SP9:
SP10: -
SP11:
SP12: -
SP13:

ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for UNC45A Gene

GeneLoc Exon Structure for
UNC45A
ECgene alternative splicing isoforms for
UNC45A

Expression for UNC45A Gene

mRNA expression in normal human tissues for UNC45A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC45A Gene

This gene is overexpressed in Bone (42.4) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UNC45A Gene



SOURCE GeneReport for Unigene cluster for UNC45A Gene Hs.389461

mRNA Expression by UniProt/SwissProt for UNC45A Gene

Q9H3U1-UN45A_HUMAN
Tissue specificity: Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach.
genes like me logo Genes that share expression patterns with UNC45A: view

Protein tissue co-expression partners for UNC45A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UNC45A Gene

Orthologs for UNC45A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UNC45A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC45A 35
  • 95.15 (n)
  • 93.73 (a)
UNC45A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC45A 36
  • 95 (a)
OneToOne
UNC45A 35
  • 91.04 (n)
  • 94.92 (a)
dog
(Canis familiaris)
Mammalia UNC45A 35
  • 90.32 (n)
  • 94.81 (a)
UNC45A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc45a 16
Unc45a 35
  • 88.84 (n)
  • 94.07 (a)
Unc45a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNC45A 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC45A 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc45a 35
  • 89.05 (n)
  • 94.39 (a)
chicken
(Gallus gallus)
Aves UNC45A 35
  • 74.92 (n)
  • 75.03 (a)
UNC45A 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC45A 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc45a 35
  • 67.85 (n)
  • 71.64 (a)
zebrafish
(Danio rerio)
Actinopterygii unc45a 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-45 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-45 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 36
  • 16 (a)
ManyToMany
TOM71 36
  • 13 (a)
ManyToMany
Species with no ortholog for UNC45A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC45A Gene

ENSEMBL:
Gene Tree for UNC45A (if available)
TreeFam:
Gene Tree for UNC45A (if available)

Paralogs for UNC45A Gene

Paralogs for UNC45A Gene

(1) SIMAP similar genes for UNC45A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNC45A: view

Variants for UNC45A Gene

Sequence variations from dbSNP and Humsavar for UNC45A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_052629 -
rs2289618 -- 90,935,839(-) CACCA(C/T)CCTGA intron-variant
rs2289619 -- 90,935,824(-) CAAAA(A/G)ACATC intron-variant
rs3841498 -- 90,939,880(+) CATAG(-/CACCCTTCACCCATGTAG)GCCCC intron-variant
rs6496739 -- 90,951,200(+) tggcg(A/C/T)tttac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC45A Gene

Variant ID Type Subtype PubMed ID
nsv833089 CNV Loss 17160897
nsv515661 CNV Loss 19592680
nsv833090 CNV Loss 17160897

Variation tolerance for UNC45A Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC45A Gene

HapMap Linkage Disequilibrium report
UNC45A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC45A Gene

Disorders for UNC45A Gene

Relevant External Links for UNC45A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC45A

No disorders were found for UNC45A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC45A Gene

Publications for UNC45A Gene

  1. UCS proteins: chaperones for myosin and co-chaperones for Hsp90. (PMID: 25487020) Ni W. … Odunuga O.O. (Subcell. Biochem. 2015) 2 3 67
  2. UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation. (PMID: 25444911) Jilani Y. … Chadli A. (Cancer Lett. 2015) 2 3
  3. Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. (PMID: 17872978) Bazzaro M. … Roden R.B. (Am. J. Pathol. 2007) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for UNC45A Gene

Sources for UNC45A Gene

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