Aliases for UNC45A Gene
External Ids for UNC45A Gene
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]
GeneCards Summary for UNC45A Gene
UNC45A (Unc-45 Homolog A (C. Elegans)) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include Hsp90 protein binding. An important paralog of this gene is SPAG1.
UniProtKB/Swiss-Prot for UNC45A Gene
Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).