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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UNC13B Gene

protein-coding   GIFtS: 59
GCID: GC09P035117

unc-13 homolog B (C. elegans)

(Previous name: unc-13-like (C. elegans) )
(Previous symbol: UNC13)
 Explore 6 diseases affiliated with
UNC13B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UNC13B    

Aliases
for UNC13B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Unc-13 Homolog B (C. Elegans)1 2     Homolog Of Rat Munc13 (Diacylglycerol-Binding)2
UNC131 2 3 5     Munc13-23
Unc13h21 2     Protein Unc-13 Homolog B2
MUNC132 5     Munc13-23
Hmunc131     Munc131
Unc-13-Like (C. Elegans)1     

External Ids:    HGNC: 125661   Entrez Gene: 104972   Ensembl: ENSG000001987227   OMIM: 6058365   UniProtKB: O147953   

Export aliases for UNC13B gene to outside databases

Previous GC identifers: GC09P035153 GC09P035154 GC09P035155


Summaries
for UNC13B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UNC13B:
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein
shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1
domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells
transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other
species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: UN13B_HUMAN, O14795
Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger
pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and
participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic
vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity)

Gene Wiki entry for UNC13B


Genomic Views
for UNC13B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UNC13B gene promoter:
         STAT5B   HTF   FOXD1   RelA   CUTL1   GATA-1   Egr-4   Egr-2   c-Rel   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UNC13B promoter sequence
   Search SABiosciences Chromatin IP Primers for UNC13B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC13B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

UNC13B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UNC13B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P035117:  view genomic region     (about GC identifiers)

Start:
 35,161,989 bp from pter      End:
 35,405,335 bp from pter
Size:
 243,347 bases      Orientation:
 plus strand

Proteins
for UNC13B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UN13B_HUMAN, O14795 (See protein sequence)
Recommended Name: Protein unc-13 homolog B  
Size: 1591 amino acids; 180679 Da
Subunit: Interacts with RIMS1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cell membrane
(By similarity). Cell junction, synapse (By similarity). Note=Localized to synapses. Translocated to the plasma
membrane in response to phorbol ester binding (By similarity)
Secondary accessions: Q5VYM8

Explore the universe of human proteins at neXtProt for UNC13B: NX_O14795

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14795

    • UNC13B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006368.3  
    ENSEMBL proteins: 
     ENSP00000380006   ENSP00000367756   ENSP00000367757  

    Human Recombinant Protein Products: 
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    Uscn Proteins for UNC13B

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm TAS10233166
    GO:0005794Golgi apparatus TAS9607201
    GO:0005886plasma membrane IEA--
    GO:0030054cell junction IEA--


    UNC13B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UNC13B

    Protein Domains /
    Families
    for UNC13B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UNC13B for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR014772 Munc13_dom-2
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR010439 Ca-dep_secretion_activator
     IPR019558 Munc13_subgr_dom-2
     IPR014770 Munc13_1

    Graphical View of Domain Structure for InterPro Entry O14795

    ProtoNet protein and cluster: O14795

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB010439 Protein of unknown function DUF1041


    UniProtKB/Swiss-Prot: UN13B_HUMAN, O14795
    Domain: The C2 domains are not involved in calcium-dependent phospholipid binding (By similarity)
    Similarity: Belongs to the unc-13 family
    Similarity: Contains 3 C2 domains
    Similarity: Contains 1 MHD1 (MUNC13 homology domain 1) domain
    Similarity: Contains 1 MHD2 (MUNC13 homology domain 2) domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger


    Function
    for UNC13B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UN13B_HUMAN, O14795
    Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger
    pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and
    participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic
    vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity)

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC13B (see all 15):
    hsa-miR-607 hsa-miR-3688-3p hsa-miR-183 hsa-miR-3120-3p hsa-miR-29a hsa-miR-29c hsa-miR-545 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: UNC13B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC13B (see all 7)
    OriGene shRNA RFP: UNC13B
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS9607201
    GO:0004872receptor activity TAS9607201
    GO:0046872metal ion binding IEA--


    UNC13B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UNC13B:
     Decreased viability 

    Animal Models:
         Mouse knock-out Unc13btm1Rmnd for UNC13B
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Unc13b):
     behavior/neurological  mortality/aging  nervous system  no phenotypic analysis  vision/eye 

    UNC13B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UNC13B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synaptic Vesicle Pathway
    		Synaptic Vesicle Pathway1.00
    2Monoamine Transport
    		Monoamine Transport1.00
    3Serotonin Neurotransmitter Release Cycle
    		Effects of Botulinum toxin0.40


    3 BioSystems Pathways for UNC13B 
        Monoamine Transport
    Synaptic Vesicle Pathway
    Effects of Botulinum toxin


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC13B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/20 Interacting proteins for UNC13B (O147952, 3 ENSP000003677564) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOE1Q96GM82, 3MINT-64603 I2D: score=4 
    CALM1P621583I2D: score=2 
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    DOC2AQ141833, ENSP000003400174I2D: score=2 STRING: ENSP00000340017
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006917induction of apoptosis TAS10233166
    GO:0007165signal transduction TAS9607201
    GO:0007268synaptic transmission ----
    GO:0007528neuromuscular junction development IEA--
    GO:0007588excretion TAS9607201


    UNC13B for ontologies           About GeneDecksing



    Drugs & Compounds
    for UNC13B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UNC13B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UNC13B

    10/844 HMDB Compounds for UNC13B (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    2 Novoseek chemical compound relationships for UNC13B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetylcholine 7.37 2 16391233 (1)
    calcium 0 7 17049382 (3), 15294163 (1)

    Search CenterWatch for drugs/clinical trials and news about UNC13B / UN13B 

    Transcripts
    for UNC13B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UNC13B gene: 
    NM_006377.3  

    Unigene Cluster for UNC13B:

    Unc-13 homolog B (C. elegans)
    Hs.493791  [show with all ESTs]
    Unigene Representative Sequence: NM_006377
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396787(uc010mkl.1) ENST00000378495(uc003zwq.3 uc003zwr.3)
    ENST00000485086 ENST00000481299 ENST00000378496(uc010mkm.1)

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate UNC13B (see all 15):
    hsa-miR-607 hsa-miR-3688-3p hsa-miR-183 hsa-miR-3120-3p hsa-miR-29a hsa-miR-29c hsa-miR-545 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: UNC13B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC13B (see all 7)
    OriGene shRNA RFP: UNC13B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209998.1 AF020202.1 AK296836.1 BC111781.1 EF139849.1 

    7 DOTS entries:

    DT.416834  DT.95080227  DT.91724413  DT.121169826  DT.95080223  DT.95149438  DT.434084 

    24/237 AceView cDNA sequences (see all 237):

    BI039209 CD652087 AA487105 BF876634 AA603088 BX646668 NM_006377 BU727038 
    CB306468 BI520176 BQ948072 CD656014 AL602627 BQ030306 AW083760 AA229487 
    AA416685 AI272819 AI201612 BQ717298 BE783214 BU860179 AA916571 CD622535 

    GeneLoc Exon Structure


    Expression
    for UNC13B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UNC13B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAACAAGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UNC13B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    TestisSeminiferous TubulesTestis
    TestisTestis CordTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UNC13B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UNC13B

    SOURCE GeneReport for Unigene cluster: Hs.493791

    UniProtKB/Swiss-Prot: UN13B_HUMAN, O14795
    Tissue specificity: Expressed in kidney cortical epithelial cells and brain

        SABiosciences Expression via Pathway-Focused PCR Array including UNC13B: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC13B

    Orthologs
    for UNC13B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UNC13B gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UNC13B6
    		 Uncharacterized protein
    		 84(a)
    		 1 ↔ 1
    		 Z(8057456-8241237)
    lizard
    (Anolis carolinensis)    		 Reptilia UNC13B6
    BAIAP36
    		 --
    		 63(a)
    33(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343791.1(19406-227388)
    AAWZ02037713(981-13734)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003294991 uncharacterized LOC100329499 72.15(n)
    77.82(a)    		   100329499  XM_002663514.2  XP_002663560.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta unc-136
    		 unc-13
    		 28(a)
    		 possible ortholog
    		 4(889296-925419)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-131 Protein UNC-13 54.98(n)
    55.95(a)    		   172497  NM_001026703.1  NP_001021874.1 


    ENSEMBL Gene Tree for UNC13B (if available)
    TreeFam Gene Tree for UNC13B (if available) 

    Paralogs
    for UNC13B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UNC13B gene
    UNC13C2  BAIAP32  UNC13A2  UNC13D2  
    4 SIMAP similar genes for UNC13B using alignment to 5 protein entries:     UN13B_HUMAN (see all proteins):
    UNC13B variant protein    UNC13A    UNC13C    PRKCH

    UNC13B for paralogs           About GeneDecksing



    Genomic Variants
    for UNC13B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3195 NCBI SNPs in UNC13B are shown (see all 3195)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1132209191,2
    		F--35136923(+) TCTCAC/TGTTTC 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs743432651,2
    		--35136965(+) TATACG/AGTACT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs743334251,2
    		--35137016(+) TTTATA/GTCAAT 1 -- us2k10--------
    rs750989661,2
    		--35137666(+) TCTCAC/TCTTTA 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs586561111,2
    		--35138523(+) CTCACC/TTCCCA 1 -- ut510--------
    rs1123144561,2
    		--35139815(+) CTTAGT/CACTTT 1 -- ut311Minor allele frequency- C:0.00CSA 1
    rs766966251,2
    		C--35140064(-) GACTGC/TGGGTG 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs777823601,2
    		C--35140067(-) TGGGAT/CTGCAG 1 -- ut311Minor allele frequency- C:0.00NA 2
    rs70358881,2
    		C,F,A,--35141252(+) gcacaT/Agtctg 1 -- ut316Minor allele frequency- A:0.13NA WA CSA 246
    rs1995624011,2
    		C--35141406(-) TGTTGG/TTTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for UNC13B (35161989 - 35405335 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for UNC13B
         8 CNVs: 82931 82929 65381 4618 95948 82930 70543 23901
         1 Indel: 59527

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    Disorders / Diseases
    for UNC13B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UNC13B for disorders           About GeneDecksing

    OMIM gene information: 605836    OMIM disorders: --

    6 diseases for UNC13B:    About MalaCards
    hyperglycemia    hemophagocytic lymphohistiocytosis    nephropathy    pharyngitis
    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for UNC13B:
    Hemophagocytic lymphohistiocytosis
    Human Genome Epidemiology (HuGE) Navigator: UNC13B (3 documents)

    Export disorders for UNC13B gene to outside databases

    Publications
    for UNC13B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UNC13B gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with UNC13B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy. (PubMed id 9607201)1, 2, 3 Song Y.... Silverman M. (1998)
    2. Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia. (PubMed id 10233166)1, 2 Song Y.... Silverman M. (1999)
    3. Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery. (PubMed id 9195900)1, 9 Orita S....Takai Y. (1997)
    4. Structural insights into the calmodulin-Munc13 intera ction obtained by cross-linking and mass spectrometry. (PubMed id 19492809)1, 9 Dimova K....Jahn O. (2009)
    5. The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis. (PubMed id 14593078)1, 9 Cheviet S....Regazzi R. (2004)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. Genome-wide association study identifies candidate gen es for Parkinson's disease in an Ashkenazi Jewish population. (PubMed id 21812969)1 Liu X....Lee J.H. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    External Searches for UNC13B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing UNC13B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10497 HGNC: 12566 AceView: UNC13B Ensembl:ENSG00000198722 euGenes: HUgn10497
    ECgene: UNC13B H-InvDB: UNC13B

    Other Databases showing UNC13B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UNC13B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UNC13B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UNC13B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UNC13B gene:
    Search GeneIP for patents involving UNC13B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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