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Aliases for UNC119B Gene

Aliases for UNC119B Gene

  • Unc-119 Lipid Binding Chaperone B 2 3 5
  • POC7 Centriolar Protein Homolog B (Chlamydomonas) 2
  • POC7 Centriolar Protein Homolog B 3
  • Unc-119 Homolog B (C. Elegans) 2
  • Unc119 (C.Elegans) Homolog B 2
  • Protein Unc-119 Homolog B 3
  • Unc-119 Homolog B 3
  • POC7B 3

External Ids for UNC119B Gene

Previous GeneCards Identifiers for UNC119B Gene

  • GC00U991105
  • GC12U900457
  • GC12P119634
  • GC12P121147
  • GC12P118157

Summaries for UNC119B Gene

GeneCards Summary for UNC119B Gene

UNC119B (Unc-119 Lipid Binding Chaperone B) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Cargo trafficking to the periciliary membrane. GO annotations related to this gene include lipid binding. An important paralog of this gene is UNC119.

UniProtKB/Swiss-Prot for UNC119B Gene

  • Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC119B Gene

Genomics for UNC119B Gene

Regulatory Elements for UNC119B Gene

Enhancers for UNC119B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F120598 1.6 FANTOM5 Ensembl ENCODE 11 -110.3 -110335 2.6 ELF3 ATF1 PKNOX1 KLF17 SIN3A FEZF1 RAD21 YY1 ZNF143 ZNF207 COQ5 GATC CABP1 LOC101928300 MLEC UNC119B MIR4700 C12orf43 ACADS ENSG00000256569
GH12F120583 1.4 Ensembl ENCODE 11 -126.2 -126232 2.0 CBX3 KLF17 ARID4B RAD21 GLIS2 ZNF143 CREM EGR2 ZNF263 SMARCA5 COQ5 GATC HNF1A-AS1 MLEC MIR4700 UNC119B C12orf43 ENSG00000256569 ACADS OASL
GH12F120580 0.2 ENCODE 11 -129.0 -129042 1.9 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 FOS KLF13 COQ5 GATC HNF1A-AS1 MLEC MIR4700 UNC119B C12orf43 ACADS ENSG00000256569 OASL
GH12F120826 0.6 Ensembl 10.8 +116.1 116066 0.2 ZBTB33 KDM1A SPPL3 ACADS ENSG00000256569 MIR4700 UNC119B ENSG00000255946 PIR38395
GH12F120828 0.4 Ensembl 10.8 +118.5 118466 0.2 SMARCE1 FOXA3 ZNF121 ARID1B ZNF766 NCOR1 FOXK2 IKZF1 ADNP TRIM24 ACADS SPPL3 ENSG00000256569 MIR4700 UNC119B PIR38395 ENSG00000255946
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UNC119B on UCSC Golden Path with GeneCards custom track

Promoters for UNC119B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001781795 365 1601 PKNOX1 ZNF493 ZFP64 ARID4B SIN3A ZSCAN9 DNMT3B YY1 ZNF766 GLIS2
ENSR00000438186 1465 201 ZNF766 MLLT1 PRDM1

Genomic Location for UNC119B Gene

Chromosome:
12
Start:
120,710,435 bp from pter
End:
120,723,640 bp from pter
Size:
13,206 bases
Orientation:
Plus strand

Genomic View for UNC119B Gene

Genes around UNC119B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC119B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC119B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC119B Gene

Proteins for UNC119B Gene

  • Protein details for UNC119B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIH7-U119B_HUMAN
    Recommended name:
    Protein unc-119 homolog B
    Protein Accession:
    A6NIH7

    Protein attributes for UNC119B Gene

    Size:
    251 amino acids
    Molecular mass:
    28137 Da
    Quaternary structure:
    • Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with C5orf30; interaction only takes place when UNC119B is not liganded with myristoylated proteins.
    • Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with C5orf30; interaction only takes place when UNC119B is not liganded with myristoylated proteins.

neXtProt entry for UNC119B Gene

Post-translational modifications for UNC119B Gene

  • Ubiquitination at Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC119B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC119B Gene

Domains & Families for UNC119B Gene

Protein Domains for UNC119B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UNC119B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIH7

UniProtKB/Swiss-Prot:

U119B_HUMAN :
  • Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
  • Belongs to the PDE6D/unc-119 family.
Domain:
  • Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
Family:
  • Belongs to the PDE6D/unc-119 family.
genes like me logo Genes that share domains with UNC119B: view

No data available for Gene Families for UNC119B Gene

Function for UNC119B Gene

Molecular function for UNC119B Gene

UniProtKB/Swiss-Prot Function:
Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

Gene Ontology (GO) - Molecular Function for UNC119B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22085962
GO:0008289 lipid binding IEA,IDA 22085962
genes like me logo Genes that share ontologies with UNC119B: view

Animal Model Products

miRNA for UNC119B Gene

miRTarBase miRNAs that target UNC119B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC119B Gene

Localization for UNC119B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC119B Gene

Cell projection, cilium. Note=Enriched at the transition zone and extended into the proximal end of the cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC119B Gene COMPARTMENTS Subcellular localization image for UNC119B gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UNC119B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005929 cilium IEA --
GO:0035869 ciliary transition zone IDA 22085962
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with UNC119B: view

Pathways & Interactions for UNC119B Gene

genes like me logo Genes that share pathways with UNC119B: view

Gene Ontology (GO) - Biological Process for UNC119B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030030 cell projection organization IEA --
GO:0042953 lipoprotein transport IDA 22085962
GO:0060271 cilium assembly IMP 22085962
genes like me logo Genes that share ontologies with UNC119B: view

No data available for SIGNOR curated interactions for UNC119B Gene

Transcripts for UNC119B Gene

mRNA/cDNA for UNC119B Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UNC119B Gene

Unc-119 homolog B (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC119B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for UNC119B Gene

GeneLoc Exon Structure for
UNC119B
ECgene alternative splicing isoforms for
UNC119B

Expression for UNC119B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UNC119B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC119B Gene

This gene is overexpressed in Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UNC119B Gene



Protein tissue co-expression partners for UNC119B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNC119B Gene:

UNC119B

SOURCE GeneReport for Unigene cluster for UNC119B Gene:

Hs.127610
genes like me logo Genes that share expression patterns with UNC119B: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UNC119B Gene

Orthologs for UNC119B Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC119B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC119B 34 35
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia UNC119B 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC119B 34 35
  • 93.63 (n)
cow
(Bos Taurus)
Mammalia UNC119B 34 35
  • 90.31 (n)
mouse
(Mus musculus)
Mammalia Unc119b 34 16 35
  • 85.39 (n)
rat
(Rattus norvegicus)
Mammalia Unc119b 34
  • 85.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UNC119B 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC119B 34 35
  • 76.42 (n)
lizard
(Anolis carolinensis)
Reptilia UNC119B 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc119b 34
  • 74.47 (n)
zebrafish
(Danio rerio)
Actinopterygii unc119.1 34 35
  • 71.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta unc-119 35
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-119 34 35
  • 62.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11065 35
  • 56 (a)
OneToMany
Species where no ortholog for UNC119B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC119B Gene

ENSEMBL:
Gene Tree for UNC119B (if available)
TreeFam:
Gene Tree for UNC119B (if available)

Paralogs for UNC119B Gene

Paralogs for UNC119B Gene

(2) SIMAP similar genes for UNC119B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UNC119B: view

Variants for UNC119B Gene

Sequence variations from dbSNP and Humsavar for UNC119B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000614 -- 120,711,137(+) CCAGC(C/T)CTCTG intron-variant
rs1000615 -- 120,711,372(+) GAATC(A/C)TGCTT intron-variant
rs1055059 -- 120,722,289(+) CCCAG(C/T)AGGAC upstream-variant-2KB, utr-variant-3-prime
rs1055070 -- 120,723,245(+) CTGAC(G/T)CCTCA nc-transcript-variant, utr-variant-3-prime
rs10849780 -- 120,719,242(+) ACTCA(A/G)AACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC119B Gene

Variant ID Type Subtype PubMed ID
esv2658765 CNV deletion 23128226
esv3630930 CNV loss 21293372
nsv1143712 CNV deletion 24896259
nsv521928 CNV gain 19592680

Variation tolerance for UNC119B Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC119B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC119B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC119B Gene

Disorders for UNC119B Gene

Relevant External Links for UNC119B

Genetic Association Database (GAD)
UNC119B
Human Genome Epidemiology (HuGE) Navigator
UNC119B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC119B

No disorders were found for UNC119B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC119B Gene

Publications for UNC119B Gene

  1. Uncoordinated (UNC)119: coordinating the trafficking of myristoylated proteins. (PMID: 23000199) Constantine R. … Baehr W. (Vision Res. 2012) 2 3 64
  2. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K. … Gieger C. (Nature 2011) 3 46 64
  3. An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. (PMID: 22085962) Wright K.J. … Jackson P.K. (Genes Dev. 2011) 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64

Products for UNC119B Gene

Sources for UNC119B Gene

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