UNC119B Gene
protein-coding GIFtS: 44
GCID: GC12P121147
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unc-119 homolog B (C. elegans)(Previous name: unc119 (C.elegans) homolog B )
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Aliases
for UNC119B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Unc-119 Homolog B (C. Elegans)1 2 | | POC7B1 2 | | MGC51391 | | Unc119 (C.Elegans) Homolog B1 | | POC7 Centriolar Protein Homolog B2 | | Protein Unc-119 Homolog B2 |
Export aliases for UNC119B gene to outside databasesPrevious GC identifers: GC00U991105 GC12U900457 GC12P119634 GC12P118157 |
Summaries
for UNC119B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: U119B_HUMAN, A6NIH7Function: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subsetof N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays akey role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probablyplays a role in trafficking proteins in photoreceptor cells
|
Genomic Views
for UNC119B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UNC119B gene promoter:
Nkx3-1 Sox5 Nkx3-1 v4 Nkx3-1 v1 Gfi-1 Nkx3-1 v2 Nkx3-1 v3 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for UNC119B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC119B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24UNC119B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P121147: view genomic region
(about GC identifiers)
Start:
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121,147,831 bp from pter |
End:
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121,161,443 bp from pter |
Size:
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13,613 bases |
Orientation:
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plus strand |
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Proteins
for UNC119B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: U119B_HUMAN, A6NIH7 (See
protein sequence)Recommended Name: Protein unc-119 homolog B Size: 251 amino acids; 28137 Da
Subunit: Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading tothe release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interactswith C5orf30; interaction only takes place when UNC119B is not liganded with myristoylated proteins
Subcellular location: Cell projection, cilium. Note=Enriched at the transition zone and extended into the proximal endof the ciliumExplore the universe of human proteins at neXtProt for UNC119B: NX_A6NIH7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NIH7
UNC119B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001074002.1
ENSEMBL proteins: ENSP00000344942 ENSP00000438905
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035869 | ciliary transition zone |
IDA | -- |
UNC119B for ontologies About GeneDecksing
UNC119B Antibody Products:
Assay Products for UNC119B: |
Protein
Domains /
Families
for UNC119B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UNC119B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NIH7ProtoNet protein and cluster: A6NIH7 UniProtKB/Swiss-Prot: U119B_HUMAN, A6NIH7Domain: Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminallymyristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding(PubMed:22085962)Similarity: Belongs to the PDE6D/unc-119 family |
Function
for UNC119B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: U119B_HUMAN, A6NIH7Function: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subsetof N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays akey role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probablyplays a role in trafficking proteins in photoreceptor cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC119B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC119B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UNC119B (NM_001080533) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UNC119B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UNC119B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC119B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0008289 | lipid binding |
IDA | -- |
UNC119B for ontologies About GeneDecksing
|
Pathways & Interactions
for UNC119B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UNC119B
4 Interacting proteins for UNC119B (A6NIH72, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042953 | lipoprotein transport |
IDA | -- | | GO:0060271 | cilium morphogenesis |
IMP | -- |
UNC119B for ontologies About GeneDecksing
|
Drugs & Compounds
for UNC119B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UNC119B
Search CenterWatch for drugs/clinical trials and news about UNC119B / U119B
|
Transcripts
for UNC119B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UNC119B gene (2 alternative transcripts): NM_032661.1 NM_001080533.2 Unigene Cluster for UNC119B: Unc-119 homolog B (C. elegans) Hs.127610 [show with all ESTs]Unigene Representative Sequence: BC0700883 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000344651(uc001tyz.3) ENST00000539658 ENST00000537794
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC119B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC119B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UNC119B (NM_001080533) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UNC119B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UNC119B |
Additional cDNA sequence: AK057021.1 AK126367.1 AL137327.1 BC004815.1 BC070088.1 5 DOTS entries: DT.447693 DT.100751827 DT.92047085 DT.91740973 DT.91851393
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for UNC119B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 |
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| SP1: | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UNC119B
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Expression
for UNC119B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UNC119B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACAGTAAT
About this image
See UNC119B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UNC119B
SOURCE GeneReport for Unigene cluster: Hs.127610
SABiosciences Custom PCR Arrays for UNC119B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UNC119B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UNC119B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC119B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC119B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC119B |
Orthologs
for UNC119B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UNC119B gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for UNC119B (if available)
TreeFam Gene Tree for UNC119B (if available) |
Paralogs
for UNC119B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UNC119B gene
- UNC1192
2 SIMAP similar genes for UNC119B using alignment to 2 protein entries: U119B_HUMAN (see all proteins):DKFZp686E1393 UNC119
UNC119B for paralogs About GeneDecksing
|
Genomic Variants
for UNC119B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UNC119B (121147831 - 121161443 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UNC119B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNC119B |
|
Disorders
/ Diseases
for UNC119B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UNC119B for disorders About GeneDecksing
1  disease for UNC119B: About MalaCardsneuronitis
1 disease from the University of Copenhagen DISEASES database for UNC119B:Nephronophthisis Human Genome Epidemiology (HuGE) Navigator: UNC119B (3 documents)
Export disorders for UNC119B gene to outside databases
|
Publications
for UNC119B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UNC119B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with UNC119B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. (PubMed id 22085962)2 Wright K.J.... Jackson P.K. (2011)
- Human metabolic individuality in biomedical and pharma ceutical research. (PubMed id 21886157)1 Suhre K....Gieger C. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
|
External Searches for UNC119B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UNC119B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UNC119B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UNC119B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UNC119B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UNC119B gene:
Search GeneIP for patents involving UNC119B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UNC119B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UNC119B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UNC119B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UNC119B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for UNC119B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UNC119B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UNC119B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UNC119B | | OriGene Custom Protein Services for UNC119B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UNC119B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UNC119B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UNC119B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UNC119B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UNC119B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UNC119B |
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 |  |  |  | |
| | | | Search Tocris compounds for UNC119B |
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 | | | UNC119B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UNC119B |
|  |  |  | | | | ThermoFisher Antibodies for UNC119B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UNC119B |
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