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Aliases for UNC119B Gene

Aliases for UNC119B Gene

  • Unc-119 Lipid Binding Chaperone B 2 3 5
  • POC7 Centriolar Protein Homolog B (Chlamydomonas) 2
  • POC7 Centriolar Protein Homolog B 3
  • Unc-119 Homolog B (C. Elegans) 2
  • Unc119 (C.Elegans) Homolog B 2
  • Unc-119 Homolog B 3
  • POC7B 3

External Ids for UNC119B Gene

Previous GeneCards Identifiers for UNC119B Gene

  • GC00U991105
  • GC12U900457
  • GC12P119634
  • GC12P121147
  • GC12P118157

Summaries for UNC119B Gene

GeneCards Summary for UNC119B Gene

UNC119B (Unc-119 Lipid Binding Chaperone B) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Cargo trafficking to the periciliary membrane. GO annotations related to this gene include lipid binding. An important paralog of this gene is UNC119.

UniProtKB/Swiss-Prot for UNC119B Gene

  • Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC119B Gene

Genomics for UNC119B Gene

Regulatory Elements for UNC119B Gene

Promoters for UNC119B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UNC119B on UCSC Golden Path with GeneCards custom track

Genomic Location for UNC119B Gene

Chromosome:
12
Start:
120,710,435 bp from pter
End:
120,723,640 bp from pter
Size:
13,206 bases
Orientation:
Plus strand

Genomic View for UNC119B Gene

Genes around UNC119B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC119B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC119B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC119B Gene

Proteins for UNC119B Gene

  • Protein details for UNC119B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIH7-U119B_HUMAN
    Recommended name:
    Protein unc-119 homolog B
    Protein Accession:
    A6NIH7

    Protein attributes for UNC119B Gene

    Size:
    251 amino acids
    Molecular mass:
    28137 Da
    Quaternary structure:
    • Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with C5orf30; interaction only takes place when UNC119B is not liganded with myristoylated proteins.

neXtProt entry for UNC119B Gene

Proteomics data for UNC119B Gene at MOPED

Post-translational modifications for UNC119B Gene

  • Ubiquitination at Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC119B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC119B Gene

Domains & Families for UNC119B Gene

Protein Domains for UNC119B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UNC119B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIH7

UniProtKB/Swiss-Prot:

U119B_HUMAN :
  • Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
  • Belongs to the PDE6D/unc-119 family.
Domain:
  • Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
Family:
  • Belongs to the PDE6D/unc-119 family.
genes like me logo Genes that share domains with UNC119B: view

No data available for Gene Families for UNC119B Gene

Function for UNC119B Gene

Molecular function for UNC119B Gene

UniProtKB/Swiss-Prot Function:
Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

Gene Ontology (GO) - Molecular Function for UNC119B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22085962
genes like me logo Genes that share ontologies with UNC119B: view

Animal Model Products

CRISPR Products

miRNA for UNC119B Gene

miRTarBase miRNAs that target UNC119B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC119B Gene

Localization for UNC119B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC119B Gene

Cell projection, cilium. Note=Enriched at the transition zone and extended into the proximal end of the cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC119B Gene COMPARTMENTS Subcellular localization image for UNC119B gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for UNC119B Gene

Pathways & Interactions for UNC119B Gene

genes like me logo Genes that share pathways with UNC119B: view

Gene Ontology (GO) - Biological Process for UNC119B Gene

None

No data available for SIGNOR curated interactions for UNC119B Gene

Drugs & Compounds for UNC119B Gene

No Compound Related Data Available

Transcripts for UNC119B Gene

mRNA/cDNA for UNC119B Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UNC119B Gene

Unc-119 homolog B (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UNC119B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for UNC119B Gene

GeneLoc Exon Structure for
UNC119B
ECgene alternative splicing isoforms for
UNC119B

Expression for UNC119B Gene

mRNA expression in normal human tissues for UNC119B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC119B Gene

This gene is overexpressed in Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UNC119B Gene



SOURCE GeneReport for Unigene cluster for UNC119B Gene Hs.127610

genes like me logo Genes that share expression patterns with UNC119B: view

Protein tissue co-expression partners for UNC119B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UNC119B Gene

Orthologs for UNC119B Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC119B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC119B 36
  • 100 (a)
OneToOne
UNC119B 35
  • 99.73 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia UNC119B 35
  • 90.31 (n)
  • 93.63 (a)
UNC119B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC119B 36
  • 96 (a)
OneToOne
UNC119B 35
  • 93.63 (n)
  • 95.6 (a)
mouse
(Mus musculus)
Mammalia Unc119b 16
Unc119b 36
  • 90 (a)
OneToOne
Unc119b 35
  • 85.39 (n)
  • 90.44 (a)
oppossum
(Monodelphis domestica)
Mammalia UNC119B 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC119B 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc119b 35
  • 85.39 (n)
  • 90.04 (a)
chicken
(Gallus gallus)
Aves UNC119B 35
  • 76.42 (n)
  • 79.48 (a)
UNC119B 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC119B 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc119b 35
  • 74.47 (n)
  • 80 (a)
zebrafish
(Danio rerio)
Actinopterygii unc119.1 36
  • 68 (a)
OneToOne
unc119.1 35
  • 71.28 (n)
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta unc-119 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-119 35
  • 62.43 (n)
  • 61.9 (a)
unc-119 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11065 36
  • 56 (a)
OneToMany
Species with no ortholog for UNC119B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC119B Gene

ENSEMBL:
Gene Tree for UNC119B (if available)
TreeFam:
Gene Tree for UNC119B (if available)

Paralogs for UNC119B Gene

Paralogs for UNC119B Gene

(2) SIMAP similar genes for UNC119B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UNC119B: view

Variants for UNC119B Gene

Sequence variations from dbSNP and Humsavar for UNC119B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17847 -- 120,711,672(+) CAGCA(A/G)CATTC intron-variant
rs510900 -- 120,718,978(-) CTATA(C/T)ATCAT intron-variant
rs696335 -- 120,720,201(-) GAAAA(C/T)ACAGC utr-variant-3-prime
rs696336 -- 120,720,513(-) CAGAC(C/G/T)GAGGG utr-variant-3-prime
rs556001 -- 120,715,164(-) ACCTT(C/T)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC119B Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899557 CNV Loss 21882294
esv2658765 CNV Deletion 23128226

Variation tolerance for UNC119B Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UNC119B Gene

HapMap Linkage Disequilibrium report
UNC119B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC119B Gene

Disorders for UNC119B Gene

Relevant External Links for UNC119B

Genetic Association Database (GAD)
UNC119B
Human Genome Epidemiology (HuGE) Navigator
UNC119B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UNC119B

No disorders were found for UNC119B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC119B Gene

Publications for UNC119B Gene

  1. Uncoordinated (UNC)119: coordinating the trafficking of myristoylated proteins. (PMID: 23000199) Constantine R. … Baehr W. (Vision Res. 2012) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for UNC119B Gene

Sources for UNC119B Gene

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