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Aliases for UNC119B Gene

Aliases for UNC119B Gene

  • Unc-119 Homolog B (C. Elegans) 2 3
  • POC7 Centriolar Protein Homolog B (Chlamydomonas) 2
  • POC7 Centriolar Protein Homolog B 3
  • Unc119 (C.Elegans) Homolog B 2
  • Protein Unc-119 Homolog B 3
  • POC7B 3

External Ids for UNC119B Gene

Previous GeneCards Identifiers for UNC119B Gene

  • GC00U991105
  • GC12U900457
  • GC12P119634
  • GC12P121147
  • GC12P118157

Summaries for UNC119B Gene

GeneCards Summary for UNC119B Gene

UNC119B (Unc-119 Homolog B (C. Elegans)) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is UNC119.

UniProtKB/Swiss-Prot for UNC119B Gene

  • Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC119B Gene

Genomics for UNC119B Gene

Regulatory Elements for UNC119B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UNC119B Gene

Start:
120,710,435 bp from pter
End:
120,723,640 bp from pter
Size:
13,206 bases
Orientation:
Plus strand

Genomic View for UNC119B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UNC119B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC119B Gene

Proteins for UNC119B Gene

  • Protein details for UNC119B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIH7-U119B_HUMAN
    Recommended name:
    Protein unc-119 homolog B
    Protein Accession:
    A6NIH7
    Secondary Accessions:

    Protein attributes for UNC119B Gene

    Size:
    251 amino acids
    Molecular mass:
    28137 Da
    Quaternary structure:
    • Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with C5orf30; interaction only takes place when UNC119B is not liganded with myristoylated proteins.

neXtProt entry for UNC119B Gene

Proteomics data for UNC119B Gene at MOPED

Post-translational modifications for UNC119B Gene

  • Ubiquitination at Lys86
  • Modification sites at PhosphoSitePlus

Other Protein References for UNC119B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC119B Gene

Domains for UNC119B Gene

Protein Domains for UNC119B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UNC119B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIH7

UniProtKB/Swiss-Prot:

U119B_HUMAN :
  • A6NIH7
Domain:
  • Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
Family:
  • Belongs to the PDE6D/unc-119 family.
genes like me logo Genes that share domains with UNC119B: view

No data available for Gene Families for UNC119B Gene

Function for UNC119B Gene

Molecular function for UNC119B Gene

UniProtKB/Swiss-Prot Function:
Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

Gene Ontology (GO) - Molecular Function for UNC119B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22085962
GO:0008289 lipid binding IDA 22085962
genes like me logo Genes that share ontologies with UNC119B: view

Animal Model Products

CRISPR Products

miRNA for UNC119B Gene

miRTarBase miRNAs that target UNC119B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNC119B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UNC119B Gene

Localization for UNC119B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC119B Gene

Cell projection, cilium. Note=Enriched at the transition zone and extended into the proximal end of the cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UNC119B Gene COMPARTMENTS Subcellular localization image for UNC119B gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UNC119B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0035869 ciliary transition zone IDA 22085962
GO:0072372 primary cilium TAS --
genes like me logo Genes that share ontologies with UNC119B: view

Pathways for UNC119B Gene

SuperPathways for UNC119B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UNC119B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0042953 lipoprotein transport IDA 22085962
GO:0060271 cilium morphogenesis IMP 22085962
genes like me logo Genes that share ontologies with UNC119B: view

No data available for Pathways by source for UNC119B Gene

Transcripts for UNC119B Gene

mRNA/cDNA for UNC119B Gene

(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UNC119B Gene

Unc-119 homolog B (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UNC119B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC119B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for UNC119B Gene

GeneLoc Exon Structure for
UNC119B
ECgene alternative splicing isoforms for
UNC119B

Expression for UNC119B Gene

mRNA expression in normal human tissues for UNC119B Gene

Protein differential expression in normal tissues for UNC119B Gene

This gene is overexpressed in Fetal ovary (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UNC119B Gene

SOURCE GeneReport for Unigene cluster for UNC119B Gene Hs.127610

genes like me logo Genes that share expressions with UNC119B: view

Expression partners for UNC119B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UNC119B Gene

Orthologs for UNC119B Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC119B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UNC119B 35
  • 90.31 (n)
  • 93.63 (a)
UNC119B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC119B 35
  • 93.63 (n)
  • 95.6 (a)
UNC119B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc119b 35
  • 85.39 (n)
  • 90.44 (a)
Unc119b 16
Unc119b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UNC119B 35
  • 99.73 (n)
  • 100 (a)
UNC119B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc119b 35
  • 85.39 (n)
  • 90.04 (a)
oppossum
(Monodelphis domestica)
Mammalia UNC119B 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC119B 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC119B 35
  • 76.42 (n)
  • 79.48 (a)
UNC119B 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC119B 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc119b 35
  • 74.47 (n)
  • 80 (a)
zebrafish
(Danio rerio)
Actinopterygii unc119.1 35
  • 71.28 (n)
  • 75 (a)
unc119.1 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-119 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-119 35
  • 62.43 (n)
  • 61.9 (a)
unc-119 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11065 36
  • 56 (a)
OneToMany
Species with no ortholog for UNC119B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC119B Gene

ENSEMBL:
Gene Tree for UNC119B (if available)
TreeFam:
Gene Tree for UNC119B (if available)

Paralogs for UNC119B Gene

Paralogs for UNC119B Gene

Selected SIMAP similar genes for UNC119B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UNC119B: view

Variants for UNC119B Gene

Sequence variations from dbSNP and Humsavar for UNC119B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs17847 -- 120,711,672(+) CAGCA(A/G)CATTC intron-variant
rs476676 -- 120,716,821(-) CTCTA(A/C)AGCCA intron-variant
rs510900 -- 120,718,978(-) CTATA(C/T)ATCAT intron-variant
rs547245 -- 120,714,315(-) AAAAA(A/C)CCCAC intron-variant
rs548093 -- 120,714,491(-) ATACA(A/G)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UNC119B Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899557 CNV Loss 21882294
esv2658765 CNV Deletion 23128226

Relevant External Links for UNC119B Gene

HapMap Linkage Disequilibrium report
UNC119B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC119B Gene

Disorders for UNC119B Gene

(1) University of Copenhagen DISEASES for UNC119B Gene

Relevant External Links for UNC119B

Genetic Association Database (GAD)
UNC119B
Human Genome Epidemiology (HuGE) Navigator
UNC119B
genes like me logo Genes that share disorders with UNC119B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for UNC119B Gene

Publications for UNC119B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K. … Gieger C. (Nature 2011) 3 48

Products for UNC119B Gene

Sources for UNC119B Gene

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