Aliases for UNC119 Gene
External Ids for UNC119 Gene
Previous GeneCards Identifiers for UNC119 Gene
This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for UNC119 Gene
UNC119 (Unc-119 Lipid Binding Chaperone) is a Protein Coding gene. Diseases associated with UNC119 include Immunodeficiency 13 and Cone-Rod Dystrophy. Among its related pathways are IL-5 Signaling Pathway. GO annotations related to this gene include lipid binding. An important paralog of this gene is MIR4700.
UniProtKB/Swiss-Prot for UNC119 Gene
Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.