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Aliases for UMPS Gene

Aliases for UMPS Gene

  • Uridine Monophosphate Synthetase 2 3
  • UMP Synthase 3 4
  • OPRT 3 6
  • Orotate Phosphoribosyl Transferase And Orotidine-5-Decarboxylase 2
  • Orotidine 5-Phosphate Decarboxylase 3
  • Orotate Phosphoribosyltransferase 3
  • Uridine 5-Monophosphate Synthase 3
  • OMPdecase 3
  • OPRTase 3

External Ids for UMPS Gene

Previous GeneCards Identifiers for UMPS Gene

  • GC03P121158
  • GC03P124466
  • GC03P125731
  • GC03P125770
  • GC03P125931
  • GC03P121823
  • GC03P124449

Summaries for UMPS Gene

Entrez Gene Summary for UMPS Gene

  • This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for UMPS Gene

UMPS (Uridine Monophosphate Synthetase) is a Protein Coding gene. Diseases associated with UMPS include orotic aciduria and malaria. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include orotate phosphoribosyltransferase activity and orotidine-5-phosphate decarboxylase activity.

Gene Wiki entry for UMPS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UMPS Gene

Genomics for UMPS Gene

Regulatory Elements for UMPS Gene

Genomic Location for UMPS Gene

124,730,366 bp from pter
124,749,273 bp from pter
18,908 bases
Plus strand

Genomic View for UMPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UMPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UMPS Gene

Proteins for UMPS Gene

  • Protein details for UMPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uridine 5-monophosphate synthase
    Protein Accession:
    Secondary Accessions:
    • B5LY68
    • B5LY72
    • O00758
    • O00759
    • O00760
    • Q16862
    • Q9H3Q2
    • Q9UG49

    Protein attributes for UMPS Gene

    480 amino acids
    Molecular mass:
    52222 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=CAB45710.3; Type=Erroneous termination; Positions=430; Note=Translated as Gln.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UMPS Gene

    Alternative splice isoforms for UMPS Gene


neXtProt entry for UMPS Gene

Proteomics data for UMPS Gene at MOPED

Post-translational modifications for UMPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UMPS Gene

Antibody Products

No data available for DME Specific Peptides for UMPS Gene

Domains for UMPS Gene

Graphical View of Domain Structure for InterPro Entry



  • P11172
  • In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  • In the C-terminal section; belongs to the OMP decarboxylase family.
genes like me logo Genes that share domains with UMPS: view

No data available for Gene Families for UMPS Gene

Function for UMPS Gene

Molecular function for UMPS Gene

GENATLAS Biochemistry:
uridine monophosphate synthase,pyrimidine de novo biosynthesis (see ODC,OPRT)
UniProtKB/Swiss-Prot CatalyticActivity:
Orotidine 5-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
UniProtKB/Swiss-Prot CatalyticActivity:
Orotidine 5-phosphate = UMP + CO(2)

Gene Ontology (GO) - Molecular Function for UMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004588 orotate phosphoribosyltransferase activity TAS --
GO:0004590 orotidine-5-phosphate decarboxylase activity TAS --
GO:0016740 transferase activity --
genes like me logo Genes that share ontologies with UMPS: view

Phenotypes for UMPS Gene

GenomeRNAi human phenotypes for UMPS:
genes like me logo Genes that share phenotypes with UMPS: view

Animal Model Products

miRNA for UMPS Gene

miRTarBase miRNAs that target UMPS

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UMPS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UMPS Gene

Localization for UMPS Gene

Subcellular locations from

Jensen Localization Image for UMPS Gene COMPARTMENTS Subcellular localization image for UMPS gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15890648
GO:0005737 cytoplasm IDA 15890648
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UMPS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UMPS Gene

Pathways for UMPS Gene

genes like me logo Genes that share pathways with UMPS: view

UniProtKB/Swiss-Prot P11172-UMPS_HUMAN

  • Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2

Gene Ontology (GO) - Biological Process for UMPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006207 de novo pyrimidine nucleobase biosynthetic process IEA --
GO:0006221 pyrimidine nucleotide biosynthetic process --
GO:0006222 UMP biosynthetic process IDA 11730338
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with UMPS: view

Compounds for UMPS Gene

(9) HMDB Compounds for UMPS Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
Orotic acid
  • uracil-6-carboxylate
  • 6-Carboxyuridine
Orotidylic acid
  • 5'-OMP
Phosphoribosyl pyrophosphate
  • 5-Phospho-a-D-ribose-1-diphosphate

(2) Drugbank Compounds for UMPS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 5-Fluorouracil
51-21-8 enzyme substrate

(27) Novoseek inferred chemical compound relationships for UMPS Gene

Compound -log(P) Hits PubMed IDs
orotic acid 98 131
orotidine 5-monophosphate 93.5 29
thymidylate 92 71
5fluorouracil 86.4 133
poly u 82.7 27

(3) PharmGKB related drug/compound annotations for UMPS Gene

Drug/compound Annotation
fluorouracil CA
leucovorin CA
tegafur CA
genes like me logo Genes that share compounds with UMPS: view

Transcripts for UMPS Gene

Unigene Clusters for UMPS Gene

Uridine monophosphate synthetase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UMPS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UMPS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: -
SP4: -
SP5: - - -

Relevant External Links for UMPS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UMPS Gene

mRNA expression in normal human tissues for UMPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UMPS Gene

This gene is overexpressed in Tonsil (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UMPS Gene

SOURCE GeneReport for Unigene cluster for UMPS Gene Hs.2057

genes like me logo Genes that share expressions with UMPS: view

Expression partners for UMPS Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UMPS Gene

Orthologs for UMPS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UMPS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UMPS 35
  • 86.87 (n)
  • 84.37 (a)
  • 84 (a)
(Canis familiaris)
Mammalia UMPS 35
  • 90.62 (n)
  • 92.11 (a)
  • 92 (a)
(Mus musculus)
Mammalia Umps 35
  • 83.54 (n)
  • 88.75 (a)
Umps 16
Umps 36
  • 89 (a)
(Pan troglodytes)
Mammalia UMPS 35
  • 99.17 (n)
  • 98.54 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Umps 35
  • 84.51 (n)
  • 90 (a)
(Monodelphis domestica)
Mammalia UMPS 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia UMPS 36
  • 74 (a)
(Gallus gallus)
Aves UMPS 35
  • 73.31 (n)
  • 74.84 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
-- 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia umps 35
  • 67.55 (n)
  • 71.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15949 35
(Danio rerio)
Actinopterygii umps 35
  • 62.85 (n)
  • 64.33 (a)
zgc55723 35
umps 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5453 35
fruit fly
(Drosophila melanogaster)
Insecta r-l 37
  • 46 (a)
r-l 35
  • 52.82 (n)
  • 48.39 (a)
r-l 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004175 35
  • 54.62 (n)
  • 51.4 (a)
(Caenorhabditis elegans)
Secernentea R12E2.11 37
  • 46 (a)
R12E2.11 36
  • 39 (a)
umps-1 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URA3 36
  • 49 (a)
URA3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G54470 35
  • 57.46 (n)
  • 56.1 (a)
(Glycine max)
eudicotyledons Gma.5031 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6709 35
(Hordeum vulgare)
Liliopsida Hv.9017 35
(Oryza sativa)
Liliopsida Os.4468 35
Os01g0951200 35
  • 55.98 (n)
  • 54.27 (a)
(Triticum aestivum)
Liliopsida Ta.27185 35
(Zea mays)
Liliopsida Zm.6787 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9304 36
  • 52 (a)
Species with no ortholog for UMPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UMPS Gene

Gene Tree for UMPS (if available)
Gene Tree for UMPS (if available)

Paralogs for UMPS Gene

No data available for Paralogs for UMPS Gene

Variants for UMPS Gene

Sequence variations from dbSNP and Humsavar for UMPS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13146 -- 124,743,961(+) ATTGG(C/T)AAACG reference, synonymous-codon, nc-transcript-variant
rs591886 -- 124,748,570(-) AGGAG(C/T)CCTCT utr-variant-3-prime, nc-transcript-variant
rs591896 -- 124,748,569(-) GGAGC(A/C)CTCTG utr-variant-3-prime, nc-transcript-variant
rs591963 -- 124,748,514(-) GGCTA(A/G)GCAAA utr-variant-3-prime, nc-transcript-variant
rs593292 -- 124,748,222(-) CCGGG(A/C)GCAGT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for UMPS Gene

Variant ID Type Subtype PubMed ID
nsv877402 CNV Gain 21882294
nsv877403 CNV Loss 21882294

Relevant External Links for UMPS Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UMPS Gene

Disorders for UMPS Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for UMPS Gene in MalaCards »

(3) Diseases for UMPS Gene including...

(1) OMIM Diseases for UMPS Gene (613891)


  • Orotic aciduria 1 (ORAC1) [MIM:258900]: A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies. {ECO:0000269 PubMed:9042911}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for UMPS Gene

(26) Novoseek inferred disease relationships for UMPS Gene

Disease -log(P) Hits PubMed IDs
orotic aciduria hereditary 81.5 1
orotic aciduria 69.3 1
metastatic gastric cancer 67.2 1
colorectal cancer 62.6 29
gastric cancer 61.9 17

Genatlas disease for UMPS Gene

orotic aciduria I (O5D & OPT deficiency)

Relevant External Links for UMPS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UMPS: view

Publications for UMPS Gene

  1. Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families. (PMID: 9042911) Suchi M. … Wada Y. (Am. J. Hum. Genet. 1997) 3 4 23
  2. The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer. (PMID: 16328050) Kitajima M. … Ochiai T. (Oncol. Rep. 2006) 3 23 48
  3. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. (PMID: 18184586) Wittmann J.G. … Rudolph M.G. (Structure 2008) 3 4 23
  4. Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil. (PMID: 17854773) Sakamoto E. … Oka T. (Biochem. Biophys. Res. Commun. 2007) 3 23
  5. Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy. (PMID: 18597678) Ishikawa M. … Kashiwagi Y. (BMC Cancer 2008) 3 23

Products for UMPS Gene

Sources for UMPS Gene

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