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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UMPS Gene

protein-coding   GIFtS: 64
GCID: GC03P124449

uridine monophosphate synthetase
 Explore 33 diseases affiliated with
UMPS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UMPS    

Aliases
for UMPS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Uridine Monophosphate Synthetase1 2     OPRTase2
UMP Synthase2 3     Orotate Phosphoribosyltransferase2
OMPdecase2     Orotidine 5'-Phosphate Decarboxylase2
OPRT2     Uridine 5'-Monophosphate Synthase2

External Ids:    HGNC: 125631   Entrez Gene: 73722   Ensembl: ENSG000001144917   OMIM: 6138915   UniProtKB: P111723   
ORGUL members:         
NONCODE:n409262    

Export aliases for UMPS gene to outside databases

Previous GC identifers: GC03P121158 GC03P124466 GC03P125731 GC03P125770 GC03P125931 GC03P121823


Summaries
for UMPS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UMPS:
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the
final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal
enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal
reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to
uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Mar 2010)

Gene Wiki entry for UMPS (Uridine monophosphate synthetase)


Genomic Views
for UMPS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UMPS gene promoter:
         ER-alpha   AML1a   HTF   AREB6   E2F   E2F-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UMPS promoter sequence
   Search SABiosciences Chromatin IP Primers for UMPS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UMPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13   Ensembl cytogenetic band:  3q21.2   HGNC cytogenetic band: 3q13

UMPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UMPS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P124449:  view genomic region     (about GC identifiers)

Start:
 124,449,213 bp from pter      End:
 124,468,120 bp from pter
Size:
 18,908 bases      Orientation:
 plus strand

Proteins
for UMPS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UMPS_HUMAN, P11172 (See protein sequence)
Recommended Name: Uridine 5'-monophosphate synthase  
Size: 480 amino acids; 52222 Da
Subunit: Homodimer
Sequence caution: Sequence=CAB45710.3; Type=Erroneous termination; Positions=430; Note=Translated as Gln;
6/38 PDB 3D structures from and Proteopedia for UMPS (see all 38):
2EAW (3D)        2JGY (3D)        2P1F (3D)        2QCC (3D)        2QCD (3D)        2QCE (3D)    
Secondary accessions: O00758 O00759 O00760 Q16862 Q9H3Q2 Q9UG49
Alternative splicing: 2 isoforms:  P11172-1   P11172-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UMPS: NX_P11172

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P11172

    • UMPS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000364.1  
    ENSEMBL proteins: 
     ENSP00000232607   ENSP00000417893   ENSP00000419618   ENSP00000420348   ENSP00000419121  
     ENSP00000420409   ENSP00000420754   ENSP00000443577   ENSP00000444988   ENSP00000397965  
    Reactome Protein details: P11172
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: UMPS
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    OriGene Custom Protein Services for UMPS 
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    Novus Biologicals UMPS Proteins
    Novus Biologicals UMPS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UMPS

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15890648
    GO:0005737cytoplasm IDA15890648
    GO:0005829cytosol TAS--


    UMPS for ontologies           About GeneDecksing



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    Uscn Antibodies for UMPS
    Search ThermoFisher Antibodies for UMPS

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    Uscn ELISAs and CLIAs for UMPS

    Protein Domains /
    Families
    for UMPS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UMPS for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR013785 Aldolase_TIM
     IPR023031 OPRT
     IPR014732 OMPdecase
     IPR018089 OMPdecase_AS
     IPR011060 RibuloseP-bd_barrel

    Graphical View of Domain Structure for InterPro Entry P11172

    ProtoNet protein and cluster: P11172

    2 Blocks protein families:
    IPB001754 Orotidine 5'-phosphate decarboxylase
    IPB002375 Purine/pyrimidine phosphoribosyl transferase


    UniProtKB/Swiss-Prot: UMPS_HUMAN, P11172
    Similarity: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family
    Similarity: In the C-terminal section; belongs to the OMP decarboxylase family


    Function
    for UMPS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UMPS_HUMAN, P11172
    Catalytic activity: Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
    Catalytic activity: Orotidine 5'-phosphate = UMP + CO(2)

         Genatlas biochemistry entry for UMPS:
    uridine monophosphate synthase,pyrimidine de novo biosynthesis (see ODC,OPRT)

    miRNA
    Products:            		miRTarBase miRNAs that target UMPS:
    hsa-mir-197 (MIRT004213)

    OriGene 3'-UTR Clone: UMPS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UMPS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate UMPS:
    hsa-miR-21* hsa-miR-141* hsa-miR-3199 hsa-miR-1197 hsa-miR-3065-3p hsa-miR-3190 hsa-miR-7 hsa-miR-1912
    SwitchGear 3'UTR luciferase reporter plasmid: UMPS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UMPS (see all 7)
    OriGene shRNA RFP: UMPS
    OriGene siRNA: UMPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UMPS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UMPS

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UMPS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UMPS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UMPS (NM_000373)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UMPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UMPS 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for UMPS
    Search LifeMap BioReagents cell lines for UMPS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UMPS

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004588orotate phosphoribosyltransferase activity TAS--
    GO:0004590orotidine-5'-phosphate decarboxylase activity TAS--
    GO:0016740transferase activity ----


    UMPS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UMPS:
     Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for UMPS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pyrimidine biosynthesis
    		Pyrimidine biosynthesis1.00
    		uridine-5-phosphate biosynthesis0.33
    2Fluoropyrimidine Activity
    		Fluoropyrimidine Activity1.00
    		Fluoropyrimidine Pathway, Pharmacokinetics0.73
    3Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    4Pyrimidine metabolism
    		Pyrimidine metabolism1.00
    5pyrimidine ribonucleotides interconversion
    		pyrimidine ribonucleotides de novo biosynthesis0.88

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for UMPS 
        Fluoropyrimidine Activity
    uridine-5-phosphate biosynthesis
    pyrimidine ribonucleotides de novo biosynthesis

    4        Reactome Pathways for UMPS
        Metabolism of nucleotides
    Metabolism
    Pyrimidine metabolism
    Pyrimidine biosynthesis

    1 PharmGKB Pathway for UMPS
        Fluoropyrimidine Pathway, Pharmacokinetics

    3         Kegg Pathways  (Kegg details for UMPS):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UMPS_HUMAN, P11172
    Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2
    Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2


    UMPS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UMPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/594 Interacting proteins for UMPS (P111722, 3 ENSP000002326074) via UniProtKB, MINT, STRING, and/or I2D (see all 594)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42EP3Q9UKI22, 3, ENSP000002953244MINT-63458 I2D: score=5 STRING: ENSP00000295324
    CASP4P496623, ENSP000003885664I2D: score=1 STRING: ENSP00000388566
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    DLSTP369573, ENSP000003353044I2D: score=3 STRING: ENSP00000335304
    PAXIP1Q6ZW493, ENSP000003840484I2D: score=1 STRING: ENSP00000384048
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006207'de novo' pyrimidine nucleobase biosynthetic process IEA--
    GO:0006221pyrimidine nucleotide biosynthetic process ----
    GO:0006222UMP biosynthetic process IDA6893554
    GO:0007565female pregnancy IEA--


    UMPS for ontologies           About GeneDecksing



    Drugs & Compounds
    for UMPS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UMPS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UMPS

    9 HMDB Compounds for UMPS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Orotic aciduracil-6-carboxylate (see all 32)65-86-1--
    Orotidine6-Carboxyuridine (see all 3)314-50-1--
    Orotidylic acid5'-OMP (see all 23)2149-82-8--
    Phosphoribosyl pyrophosphate5-Phospho-a-D-ribose-1-diphosphate (see all 37)7540-64-9--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    ThiosulfateHyposulfite (see all 14)14383-50-7--
    Uridine 5'-monophosphate5'-UMP (see all 12)58-97-9--

    1 DrugBank Compound for UMPS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    6-Hydroxyuridine-5'-Phosphate-- --target--17139284 17016423 10592235

    10/27 Novoseek chemical compound relationships for UMPS gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    orotic acid 98 216 2085181 (4), 8312245 (3), 16044965 (3), 11730338 (3) (see all 98)
    orotidine 5'-monophosphate 93.5 58 11730338 (3), 8312245 (2), 15683248 (2), 15147974 (2) (see all 21)
    thymidylate 92 109 20407238 (2), 11915731 (2), 12720098 (2), 17192711 (2) (see all 64)
    5fluorouracil 86.4 251 17854773 (7), 14770427 (6), 14713770 (6), 16328050 (4) (see all 69)
    poly u 82.7 48 7662663 (6), 8182184 (4), 9042911 (3), 15147974 (2) (see all 14)
    uridine 82 46 17192711 (2), 2162241 (1), 10736423 (1), 10969598 (1) (see all 24)
    fump 80.1 4 8645024 (2), 10927027 (1)
    dihydrouracil 80 7 16584912 (1), 8216379 (1), 8277507 (1), 10927027 (1) (see all 5)
    prpp 79.2 12 7685580 (2), 8312245 (1), 2142214 (1), 9890908 (1) (see all 6)
    thymidine 77.1 92 17192711 (2), 17637543 (2), 2162241 (1), 10736423 (1) (see all 52)

    3 PharmGKB related drug/compound annotations for UMPS gene
    Drug/compound PharmGKB Annotation
    fluorouracilCA  
    leucovorinCA  
    tegafurCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about UMPS 

    Transcripts
    for UMPS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UMPS gene: 
    NM_000373.3  

    Unigene Cluster for UMPS:

    Uridine monophosphate synthetase
    Hs.2057  [show with all ESTs]
    Unigene Representative Sequence: NR_033437
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232607(uc011bkb.2 uc003ehl.4 uc003ehn.4 uc003ehm.4 uc011bka.2 uc011bkc.2 uc011bkd.2)
    ENST00000462091 ENST00000467167 ENST00000474588 ENST00000497791 ENST00000460034
    ENST00000479719 ENST00000498715 ENST00000487622 ENST00000495751 ENST00000536109
    ENST00000538242 ENST00000413078

    miRNA
    Products:             		 OriGene 3'-UTR Clone: UMPS
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UMPS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate UMPS:
    hsa-miR-21* hsa-miR-141* hsa-miR-3199 hsa-miR-1197 hsa-miR-3065-3p hsa-miR-3190 hsa-miR-7 hsa-miR-1912
    SwitchGear 3'UTR luciferase reporter plasmid: UMPS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UMPS (see all 7)
    OriGene shRNA RFP: UMPS
    OriGene siRNA: UMPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UMPS
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UMPS 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UMPS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UMPS

    Additional cDNA sequence: 

    AB062285.1 AK291306.1 AL080099.2 BC000364.2 BC007511.2 CR456787.1 D86227.1 D86228.1 
    D86230.1 J03626.1 M36661.1 NR_033434.1 NR_033437.1 

    15 DOTS entries:

    DT.446579  DT.97826849  DT.95303887  DT.100821991  DT.100822007  DT.100821994  DT.91725814  DT.100821997 
    DT.99956399  DT.95303886  DT.95303936  DT.100821995  DT.86852957  DT.95303884  DT.95303885 

    24/283 AceView cDNA sequences (see all 283):

    BM454306 BX366051 CB130014 AA284909 CR597849 BU686871 BG109876 BM982839 
    CA440952 CR623728 CR593249 BX339589 BG025364 BM465045 AL559482 CR618739 
    BU687676 CB158412 CR614357 AL561431 AA130583 CR590318 BX345093 BQ926088 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UMPS    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                    -                       -                       -               
    SP2:                                                                    -               
    SP3:                                                                                    
    SP4:                                            -                                       
    SP5:                    -     -                 -                                       


    ECgene alternative splicing isoforms for UMPS

    Expression
    for UMPS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UMPS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTTTAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See UMPS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UMPS

    SOURCE GeneReport for Unigene cluster: Hs.2057
        SABiosciences Custom PCR Arrays for UMPS
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UMPS
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UMPS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UMPS
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UMPS

    Orthologs
    for UMPS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for UMPS gene from 11/45 species (see all 45)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Umps1 , 5 uridine monophosphate synthetase1, 5 83.54(n)1
    88.75(a)1    		   16 (24.26 cM)5
    222471  NM_009471.21  NP_033497.11 
     339547825 
    chicken
    (Gallus gallus)    		 Aves UMPS1 uridine monophosphate synthetase 73.31(n)
    74.84(a)    		   424256  NM_001031260.1  NP_001026431.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 70(a)
    70(a)
    		 many → 1
    many → 1
    		 1(78230900-78241092)
    GL344627.1(19110-26862)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.159492 Xenopus laevis transcribed sequence with weak similarity more 73.52(n)    BX848302.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc557232 hypothetical protein MGC55723 70.96(n)   393143  BC045440.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta r-l1 , 3 'de novo' pyrimidine base biosynthesis
    orotate more3
    rudimentary-like1    		 46(a)3
    52.82(n)1
    48.39(a)1    		   3 93B103
    424931  NM_079703.21  NP_524427.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea R12E2.113 purine/pyrimidine phosphoribosyl transferase 46(a)   I(4172733-4173730)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes URA3(YEL021W)4
    URA31    		 Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes more4
    Ura3p1    		 56.71(n)1
    53.53(a)1    		   5(116167-116970)4
    8566921, 4  NP_010893.31  NP_010893.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G544701 orotidine 5'-phosphate decarboxylase 57.46(n)
    56.1(a)    		   824612  NM_148875.4  NP_680130.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.44682 Oryza sativa (japonica cultivar-group) mRNA for UMP more 75.14(n)    AF210323.1 


    ENSEMBL Gene Tree for UMPS (if available)
    TreeFam Gene Tree for UMPS (if available) 

    Paralogs
    for UMPS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for UMPS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/481 NCBI SNPs in UMPS are shown (see all 481)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219178921,2
    		Cpathogenic124456430(+) TCTTGG/TAGAAG 4 G V nc-transcript-variantmis10--------
    rs567368481,2
    		C,--124447278(+) TAGGCC/ATGTGC 3 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1502577331,2
    		--124447341(+) GTTGAC/TTGGGC 3 -- us2k10--------
    rs1930652161,2
    		--124447432(+) CTCAGC/GTCTAC 3 -- us2k10--------
    rs1151568651,2
    		--124447475(+) TCTTAT/CTGAAT 3 -- us2k11Minor allele frequency- C:0.01WA 118
    rs754181621,2
    		C--124447525(+) TCATTC/TTTTTT 3 -- us2k11Minor allele frequency- T:0.50NA 2
    rs341702031,2
    		C--124447526(+) TTTTTT/-GAGCG 3 -- us2k11Minor allele frequency- -:0.00NA 2
    rs124879191,2
    		C,F,A,H,--124447544(+) TTGAGC/TGCAGT 3 -- us2k13Minor allele frequency- T:0.17WA NA EA 358
    rs622656151,2
    		C,--124447572(+) CCTGGA/TGTGCA 3 -- us2k14Minor allele frequency- T:0.09NA EA 244
    rs1832121471,2
    		--124447588(+) GCGATC/TTCGGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for UMPS (124449213 - 124468120 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UMPS: --
    Human Gene Mutation Database (HGMD): UMPS

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UMPS
    DNA2.0 Custom Variant and Variant Library Synthesis for UMPS

    Disorders / Diseases
    for UMPS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UMPS for disorders           About GeneDecksing

    OMIM gene information: 613891    OMIM disorders: --

    UniProtKB/Swiss-Prot: UMPS_HUMAN, P11172
  • Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine
    • metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some
    degree of physical and mental retardation. A minority of cases have additional features, particularly congenital
    malformations and immune deficiencies

    20/33 diseases for UMPS (see all 33):    About MalaCards
    orotic aciduria type 1    megaloblastic anemia    oral squamous cell carcinoma    squamous cell carcinoma
    neutropenia    gastric cancer    carcinoma    renal cell carcinoma
    stomach cancer    colon cancer    bladder carcinoma    pancreatic cancer
    colorectal cancer    esophagitis    pancreatitis    anemia
    esophageal carcinoma    colon carcinoma    hepatocellular carcinoma    esophageal cancer

    10/26 Novoseek disease relationships for UMPS gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    orotic aciduria hereditary 81.5 1 10851269 (1)
    orotic aciduria 69.3 1 9042911 (1)
    metastatic gastric cancer 67.2 1 16952032 (1)
    colorectal cancer 62.6 34 20407238 (2), 15272584 (2), 11383215 (2), 15968317 (2) (see all 23)
    gastric cancer 61.9 27 16142362 (3), 16044965 (2), 17089033 (2), 17237621 (2) (see all 11)
    gastric carcinoma 57 58 18095079 (7), 16912530 (6), 16612158 (5), 11265402 (4) (see all 9)
    colorectal carcinoma 45.1 10 18949394 (2), 12720098 (2), 18383874 (1), 18630501 (1) (see all 5)
    tumors 42.7 97 16142362 (5), 11265402 (4), 17854773 (4), 16788943 (4) (see all 36)
    colorectal tumors 40.9 5 12506474 (1), 16477629 (1), 17454858 (1)
    cancer 39.6 43 16044965 (3), 16734727 (3), 12720098 (2), 14713770 (2) (see all 23)

    Genatlas disease: UMPS
    orotic aciduria I (O5D & OPT deficiency)

    Genetic Association Database (GAD): UMPS
    Human Genome Epidemiology (HuGE) Navigator: UMPS (6 documents)

    Export disorders for UMPS gene to outside databases

    Publications
    for UMPS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UMPS gene, integrated from 9 sources (see all 201):
    (articles sorted by number of sources associating them with UMPS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer. (PubMed id 16328050)1, 4, 9 Kitajima M....Ochiai T. (2006)
    2. Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families. (PubMed id 9042911)1, 2, 9 Suchi M.... Wada Y. (1997)
    3. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. (PubMed id 18184586)1, 2, 9 Wittmann J.G....Rudolph M.G. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization. (PubMed id 2767686)1, 3 Qumsiyeh M.B....Suttle D.P. (1989)
    6. Molecular cloning of human UMP synthase. (PubMed id 2624233)1, 2 Suchi M....Takagi Y. (1989)
    7. Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase. (PubMed id 3279416)1, 2 Suttle D.P.... Kanalas J.J. (1988)
    8. Expression of orotate phosphoribosyl transferase in human pancreatic cancer: implication for the efficacy of uracil and tegafur-based adjuvant chemotherapy. (PubMed id 17549346)1, 9 Nio Y....Fukushima M. (2007)
    9. Expression of orotate phosphoribosyltransferase (OPRT) in hepatobiliary and pancreatic carcinoma. (PubMed id 17607371)1, 9 Sanada Y....Tsutani Y. (2007)
    10. [Predictive value of orotate phosphoribosyltransferase in chemoresistant patients with gastric carcinoma who underwent S-1-based neoadjuvant/adjuvant chemotherapy] (PubMed id 18633253)1, 9 Sakurai Y....Tsutsumi Y. (2008)

    External Searches for UMPS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UMPS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7372 HGNC: 12563 AceView: UMPS Ensembl:ENSG00000114491 euGenes: HUgn7372
    ECgene: UMPS Kegg: 7372 H-InvDB: UMPS

    Other Databases showing UMPS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UMPS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UMPS Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/UMPS
    NIEHS-SNPshttp://egp.gs.washington.edu/data/umps/

    Intellectual Property
    for UMPS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UMPS gene:
    Search GeneIP for patents involving UMPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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