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Aliases for UMODL1 Gene

Aliases for UMODL1 Gene

  • Uromodulin-Like 1 2 3
  • Olfactorin 2 3 4

External Ids for UMODL1 Gene

Summaries for UMODL1 Gene

GeneCards Summary for UMODL1 Gene

UMODL1 (Uromodulin-Like 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and peptidase inhibitor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UMODL1 Gene

Genomics for UMODL1 Gene

Genomic Location for UMODL1 Gene

Start:
42,062,959 bp from pter
End:
42,143,453 bp from pter
Size:
80,495 bases
Orientation:
Plus strand

Genomic View for UMODL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UMODL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UMODL1 Gene

Regulatory Elements for UMODL1 Gene

Proteins for UMODL1 Gene

  • Protein details for UMODL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5DID0-UROL1_HUMAN
    Recommended name:
    Uromodulin-like 1
    Protein Accession:
    Q5DID0
    Secondary Accessions:
    • C9JCE6
    • Q5DIC9
    • Q6LA40
    • Q6LA41
    • Q8N216

    Protein attributes for UMODL1 Gene

    Size:
    1318 amino acids
    Molecular mass:
    144294 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04211.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UMODL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UMODL1 Gene

Proteomics data for UMODL1 Gene at MOPED

Post-translational modifications for UMODL1 Gene

  • Glycosylation at Asn89, Asn109, Asn172, Asn322, Asn335, Asn417, Asn585, Asn713, Asn984, and Asn1050

No data available for DME Specific Peptides for UMODL1 Gene

Domains for UMODL1 Gene

UniProtKB/Swiss-Prot:

UROL1_HUMAN
Domain:
  • Contains 3 EGF-like domains.:
    • Q5DID0
  • Contains 1 EMI domain.:
    • Q5DID0
  • Contains 2 fibronectin type-III domains.:
    • Q5DID0
  • Contains 2 SEA domains.:
    • Q5DID0
  • Contains 1 WAP domain.:
    • Q5DID0
  • Contains 1 ZP domain.:
    • Q5DID0
genes like me logo Genes that share domains with UMODL1: view

No data available for Gene Families for UMODL1 Gene

Function for UMODL1 Gene

Gene Ontology (GO) - Molecular Function for UMODL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with UMODL1: view

Phenotypes for UMODL1 Gene

genes like me logo Genes that share phenotypes with UMODL1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UMODL1 Gene

Localization for UMODL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UMODL1 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UMODL1 Gene COMPARTMENTS Subcellular localization image for UMODL1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UMODL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UMODL1: view

Pathways for UMODL1 Gene

SuperPathways for UMODL1 Gene

No Data Available

Interacting Proteins for UMODL1 Gene

Gene Ontology (GO) - Biological Process for UMODL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010468 regulation of gene expression IEA --
GO:0042981 regulation of apoptotic process IEA --
GO:0048609 multicellular organismal reproductive process IEA --
genes like me logo Genes that share ontologies with UMODL1: view

No data available for Pathways by source for UMODL1 Gene

Transcripts for UMODL1 Gene

Unigene Clusters for UMODL1 Gene

Uromodulin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UMODL1 Gene

No ASD Table

Relevant External Links for UMODL1 Gene

GeneLoc Exon Structure for
UMODL1
ECgene alternative splicing isoforms for
UMODL1

Expression for UMODL1 Gene

mRNA expression in normal human tissues for UMODL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UMODL1 Gene

This gene is overexpressed in Testis (12.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for UMODL1 Gene

SOURCE GeneReport for Unigene cluster for UMODL1 Gene Hs.242520

mRNA Expression by UniProt/SwissProt for UMODL1 Gene

Q5DID0-UROL1_HUMAN
Tissue specificity: Isoform 4 is expressed at low level in kidney, testis and fetal thymus. Isoform 3 is expressed at low level in prostate, testis and fetal thymus.
genes like me logo Genes that share expressions with UMODL1: view

Orthologs for UMODL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UMODL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UMODL1 36
  • 98.38 (n)
  • 97.05 (a)
UMODL1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UMODL1 36
  • 75.6 (n)
  • 67.3 (a)
UMODL1 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UMODL1 36
  • 77.83 (n)
  • 70.19 (a)
UMODL1 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Umodl1 36
  • 72.96 (n)
  • 62.88 (a)
Umodl1 16
Umodl1 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UMODL1 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Umodl1 36
  • 73 (n)
  • 64.5 (a)
chicken
(Gallus gallus)
Aves UMODL1 36
  • 59.79 (n)
  • 53.47 (a)
UMODL1 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UMODL1 37
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia umodl1 36
  • 51.31 (n)
  • 39.48 (a)
zebrafish
(Danio rerio)
Actinopterygii umodl1 36
  • 46.08 (n)
  • 31.05 (a)
umodl1 37
  • 29 (a)
OneToOne
Species with no ortholog for UMODL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UMODL1 Gene

ENSEMBL:
Gene Tree for UMODL1 (if available)
TreeFam:
Gene Tree for UMODL1 (if available)

Paralogs for UMODL1 Gene

genes like me logo Genes that share paralogs with UMODL1: view

No data available for Paralogs for UMODL1 Gene

Variants for UMODL1 Gene

Sequence variations from dbSNP and Humsavar for UMODL1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs69686 -- 42,061,511(+) TCAGC(A/G)TCCCT upstream-variant-2KB
rs93136 -- 42,094,725(-) TCTTT(C/T)GTTGG intron-variant
rs150801 -- 42,065,569(-) CAGAG(A/C)GAGAC intron-variant
rs150802 -- 42,066,059(-) ATAAC(A/C)GCATT intron-variant
rs150803 -- 42,078,347(-) GGCCC(C/G/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UMODL1 Gene

Variant ID Type Subtype PubMed ID
nsv913777 CNV Loss 21882294
esv993470 CNV Deletion 20482838
esv2723516 CNV Deletion 23290073
esv2423716 CNV Deletion 19546169
esv2723518 CNV Deletion 23290073
esv23152 CNV Gain 19812545
dgv755e201 CNV Deletion 23290073
dgv756e201 CNV Deletion 23290073
esv2723523 CNV Deletion 23290073
esv2723524 CNV Deletion 23290073
esv2402523 CNV Deletion 18987734
nsv913778 CNV Loss 21882294
nsv525313 CNV Loss 19592680
nsv528679 CNV Loss 19592680
esv2110905 CNV Deletion 18987734
esv2723525 CNV Deletion 23290073
nsv510798 CNV Loss 20534489
esv2723526 CNV Deletion 23290073
esv26620 CNV Loss 19812545
esv2723527 CNV Deletion 23290073
esv2723529 CNV Deletion 23290073
esv2723530 CNV Deletion 23290073
esv2723531 CNV Deletion 23290073

Relevant External Links for UMODL1 Gene

HapMap Linkage Disequilibrium report
UMODL1

Disorders for UMODL1 Gene

(1) University of Copenhagen DISEASES for UMODL1 Gene

Relevant External Links for UMODL1

Genetic Association Database (GAD)
UMODL1
Human Genome Epidemiology (HuGE) Navigator
UMODL1
genes like me logo Genes that share disorders with UMODL1: view

No data available for UniProtKB/Swiss-Prot for UMODL1 Gene

Publications for UMODL1 Gene

  1. Initial characterization of an uromodulin-like 1 gene on human chromosome 21q22.3. (PMID: 15194491) Shibuya K. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3. (PMID: 18535602) Nishizaki R. … Mizuki N. (Eye (Lond) 2009) 3 23 49
  3. UMODL1/olfactorin is an extracellular membrane-bound molecule with a restricted spatial expression in olfactory and vomeronasal neurons. (PMID: 16026467) Di Schiavi E. … Rugarli E.I. (Eur. J. Neurosci. 2005) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4

Products for UMODL1 Gene

Sources for UMODL1 Gene

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