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Aliases for UMODL1 Gene

Aliases for UMODL1 Gene

  • Uromodulin Like 1 2 3 5
  • Olfactorin 2 3 4

External Ids for UMODL1 Gene

Previous GeneCards Identifiers for UMODL1 Gene

  • GC21U990105
  • GC21P042413
  • GC21P043484
  • GC21P028908

Summaries for UMODL1 Gene

GeneCards Summary for UMODL1 Gene

UMODL1 (Uromodulin Like 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and peptidase inhibitor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UMODL1 Gene

Genomics for UMODL1 Gene

Regulatory Elements for UMODL1 Gene

Enhancers for UMODL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UMODL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UMODL1 Gene

42,031,463 bp from pter
42,143,453 bp from pter
111,991 bases
Plus strand

Genomic View for UMODL1 Gene

Genes around UMODL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UMODL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UMODL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UMODL1 Gene

Proteins for UMODL1 Gene

  • Protein details for UMODL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uromodulin-like 1
    Protein Accession:
    Secondary Accessions:
    • C9JCE6
    • Q5DIC9
    • Q6LA40
    • Q6LA41
    • Q8N216

    Protein attributes for UMODL1 Gene

    1318 amino acids
    Molecular mass:
    144294 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04211.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UMODL1 Gene


neXtProt entry for UMODL1 Gene

Proteomics data for UMODL1 Gene at MOPED

Post-translational modifications for UMODL1 Gene

  • Glycosylation at Asn 89, Asn 109, Asn 172, Asn 322, Asn 335, Asn 417, Asn 585, Asn 713, Asn 984, and Asn 1050
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UMODL1 Gene

Domains & Families for UMODL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EGF-like domains.
  • Contains 3 EGF-like domains.
  • Contains 1 EMI domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 2 SEA domains.
  • Contains 1 WAP domain.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with UMODL1: view

No data available for Gene Families for UMODL1 Gene

Function for UMODL1 Gene

Gene Ontology (GO) - Molecular Function for UMODL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with UMODL1: view
genes like me logo Genes that share phenotypes with UMODL1: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UMODL1 Gene

Localization for UMODL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UMODL1 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.

Subcellular locations from

Jensen Localization Image for UMODL1 Gene COMPARTMENTS Subcellular localization image for UMODL1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UMODL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with UMODL1: view

Pathways & Interactions for UMODL1 Gene

SuperPathways for UMODL1 Gene

No Data Available

Interacting Proteins for UMODL1 Gene

Gene Ontology (GO) - Biological Process for UMODL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
GO:0060612 adipose tissue development IEA --
GO:0097211 cellular response to gonadotropin-releasing hormone IEA --
GO:2000354 regulation of ovarian follicle development IEA --
genes like me logo Genes that share ontologies with UMODL1: view

No data available for Pathways by source and SIGNOR curated interactions for UMODL1 Gene

Drugs & Compounds for UMODL1 Gene

No Compound Related Data Available

Transcripts for UMODL1 Gene

Unigene Clusters for UMODL1 Gene

Uromodulin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UMODL1 Gene

No ASD Table

Relevant External Links for UMODL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UMODL1 Gene

mRNA expression in normal human tissues for UMODL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UMODL1 Gene

This gene is overexpressed in Testis (x12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UMODL1 Gene

SOURCE GeneReport for Unigene cluster for UMODL1 Gene Hs.242520

mRNA Expression by UniProt/SwissProt for UMODL1 Gene

Tissue specificity: Isoform 4 is expressed at low level in kidney, testis and fetal thymus. Isoform 3 is expressed at low level in prostate, testis and fetal thymus.
genes like me logo Genes that share expression patterns with UMODL1: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for UMODL1 Gene

Orthologs for UMODL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UMODL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UMODL1 35
  • 75.6 (n)
  • 67.3 (a)
  • 67 (a)
(Canis familiaris)
Mammalia UMODL1 35
  • 77.83 (n)
  • 70.19 (a)
  • 69 (a)
(Mus musculus)
Mammalia Umodl1 35
  • 72.96 (n)
  • 62.88 (a)
Umodl1 16
Umodl1 36
  • 62 (a)
(Pan troglodytes)
Mammalia UMODL1 35
  • 98.38 (n)
  • 97.05 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Umodl1 35
  • 73 (n)
  • 64.5 (a)
(Ornithorhynchus anatinus)
Mammalia UMODL1 36
  • 52 (a)
(Gallus gallus)
Aves UMODL1 35
  • 59.79 (n)
  • 53.47 (a)
  • 46 (a)
(Anolis carolinensis)
Reptilia UMODL1 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia umodl1 35
  • 51.31 (n)
  • 39.48 (a)
(Danio rerio)
Actinopterygii umodl1 35
  • 46.08 (n)
  • 31.05 (a)
umodl1 36
  • 29 (a)
Species with no ortholog for UMODL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UMODL1 Gene

Gene Tree for UMODL1 (if available)
Gene Tree for UMODL1 (if available)

Paralogs for UMODL1 Gene

genes like me logo Genes that share paralogs with UMODL1: view

No data available for Paralogs for UMODL1 Gene

Variants for UMODL1 Gene

Sequence variations from dbSNP and Humsavar for UMODL1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_025668 -
rs17114359 -, - 42,090,327(+) AGCTC(A/C/G)ATGCC nc-transcript-variant, reference, missense
VAR_025671 -
rs220126 - 42,110,898(-) CGCCC(A/G/T)TGGGG nc-transcript-variant, reference, missense
rs220129 - 42,111,522(-) CCATG(A/G)TGGAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UMODL1 Gene

Variant ID Type Subtype PubMed ID
nsv913777 CNV Loss 21882294
esv993470 CNV Deletion 20482838
esv2723516 CNV Deletion 23290073
esv2423716 CNV Deletion 19546169
esv2723518 CNV Deletion 23290073
esv23152 CNV Gain 19812545
dgv755e201 CNV Deletion 23290073
dgv756e201 CNV Deletion 23290073
esv2723523 CNV Deletion 23290073
esv2723524 CNV Deletion 23290073
esv2402523 CNV Deletion 18987734
nsv913778 CNV Loss 21882294
nsv525313 CNV Loss 19592680
nsv528679 CNV Loss 19592680
esv2110905 CNV Deletion 18987734
esv2723525 CNV Deletion 23290073
nsv510798 CNV Loss 20534489
esv2723526 CNV Deletion 23290073
esv26620 CNV Loss 19812545
esv2723527 CNV Deletion 23290073
esv2723529 CNV Deletion 23290073
esv2723530 CNV Deletion 23290073
esv2723531 CNV Deletion 23290073

Variation tolerance for UMODL1 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.08; 97.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UMODL1 Gene

Disorders for UMODL1 Gene

Relevant External Links for UMODL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UMODL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UMODL1 Gene

Publications for UMODL1 Gene

  1. UMODL1/olfactorin is an extracellular membrane-bound molecule with a restricted spatial expression in olfactory and vomeronasal neurons. (PMID: 16026467) Di Schiavi E. … Rugarli E.I. (Eur. J. Neurosci. 2005) 2 3 4 67
  2. New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3. (PMID: 18535602) Nishizaki R. … Mizuki N. (Eye (Lond) 2009) 3 23
  3. Initial characterization of an uromodulin-like 1 gene on human chromosome 21q22.3. (PMID: 15194491) Shibuya K. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 3 23
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  5. Investigating the relationship between UMODL1 gene polymorphisms and high myopia: a case-control study in Chinese. (PMID: 22857148) Zhu M.M. … Yip S.P. (BMC Med. Genet. 2012) 3

Products for UMODL1 Gene

Sources for UMODL1 Gene