Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UMOD Gene

protein-coding   GIFtS: 63
GCID: GC16M020344

Uromodulin

(Previous names: uromodulin (uromucoid, Tamm-Horsfall glycoprotein))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
uromodulin1 2     HNFJ12 5
uromucoid1 2     MCKD22 5
THP2 3     Tamm-Horsfall Glycoprotein1
Tamm-Horsfall Urinary Glycoprotein2 3     Uromodulin (Uromucoid, Tamm-Horsfall Glycoprotein)1
ADMCKD22 5     HNFJ2
FJHN2 5     THGP2

External Ids:    HGNC: 125591   Entrez Gene: 73692   Ensembl: ENSG000001693447   OMIM: 1918455   UniProtKB: P079113   

Export aliases for UMOD gene to outside databases

Previous GC identifers: GC16P019829 GC16M019774 GC16M020271 GC16M020310 GC16M020251 GC16M018883


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UMOD Gene:
The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions.
Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl
phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This
protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein
in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this
gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney
disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN).
Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for UMOD Gene: 
UMOD (uromodulin) is a protein-coding gene. Diseases associated with UMOD include familial juvenile hyperuricemic nephropathy, and cystic kidney. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is GP2.

UniProtKB/Swiss-Prot: UROM_HUMAN, P07911
Function: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the
thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like
structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for
cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial
Function: Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may
contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary
tract infection and modulates formation of supersaturated salts and their crystals

Gene Wiki entry for UMOD (Tamm-Horsfall protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UMOD gene promoter:
         AhR   Nkx3-1   Nkx3-1 v4   Brachyury   XBP-1   Nkx3-1 v1   Nkx3-1 v2   HFH-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUMOD promoter sequence
   Search SABiosciences Chromatin IP Primers for UMOD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UMOD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

UMOD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UMOD gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M020344:  view genomic region     (about GC identifiers)

Start:
20,344,373 bp from pter      End:
20,367,623 bp from pter
Size:
23,251 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UROM_HUMAN, P07911 (See protein sequence)
Recommended Name: Uromodulin precursor  
Size: 640 amino acids; 69761 Da
Subcellular location: Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor,
GPI-anchor. Cell projection, cilium membrane. Note=Only a small fraction is sort to the basolateral pole of
tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalized with
NPHP1 and KIF3A
Subcellular location: Uromodulin, secreted form: Secreted
Miscellaneous: A specific, but as yet unidentified, protease(s) cleaves off and releases UMOD into urine
Secondary accessions: B3KP48 B3KRN9 Q540J6 Q6ZS84 Q8IYG0
Alternative splicing: 4 isoforms:  P07911-1   P07911-2   P07911-3   P07911-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UMOD: NX_P07911

Explore proteomics data for UMOD at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated. N-glycan heterogeneity at Asn-232: Hex7HexNAc6 (major) and dHex1Hex7HexNAc6 (minor); at Asn-322:
    dHex1Hex6HexNAc5 (minor), dHex1Hex7HexNAc6 (major) and dHex1Hex8HexNAc7 (minor); at Asn-396: Hex6HexNAc5 (major),
    dHex1Hex6HexNAc5 (minor) and Hex7HexNAc6 (minor)
  • UniProtKB: Proteolytically cleaved at a conserved C-terminal proteolytic cleavage site to generate the secreted form found
    into urine
  • View neXtProt modification sites for NX_P07911

  • UMOD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UMOD Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001008390.1  NP_001265543.1  NP_003352.2  

    ENSEMBL proteins: 
     ENSP00000379438   ENSP00000379442   ENSP00000460548   ENSP00000460374   ENSP00000458939  
     ENSP00000459738   ENSP00000460845   ENSP00000461641   ENSP00000459724   ENSP00000461120  
     ENSP00000458695   ENSP00000416346   ENSP00000306279   ENSP00000379446  

    Human Recombinant Protein Products for UMOD: 
    EMD Millipore Purified and/or Recombinant UMOD Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UMOD
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for UMOD 
    OriGene Custom Protein Services for UMOD
    GenScript Custom Purified and Recombinant Proteins Services for UMOD
    Novus Biologicals UMOD Protein
    Novus Biologicals UMOD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UMOD
    Cloud-Clone Corp. Proteins for UMOD 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA--
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016323basolateral plasma membrane IDA7028707

    UMOD for ontologies           About GeneDecksing



    UMOD Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of UMOD
    R&D Systems Antibodies for UMOD (Uromodulin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UMOD
    GenScript Custom Superior Antibodies Services for UMOD
    Novus Biologicals UMOD Antibodies
    Abcam antibodies for UMOD
    Cloud-Clone Corp. Antibodies for UMOD 
    ThermoFisher Antibodies for UMOD
    LSBio Antibodies in human, mouse, rat for UMOD 

    Assay Products for UMOD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UMOD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UMOD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UMOD 
    Cloud-Clone Corp. CLIAs for UMOD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR017977 ZP_dom_CS
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR009030 Growth_fac_rcpt_N_dom
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry P07911

    ProtoNet protein and cluster: P07911

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001507 Endoglin/CD105 antigen
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: UROM_HUMAN, P07911
    Domain: The ZP domain is involved in the polymerization of the protein to promote the formation of complex
    gel-like structure
    Similarity: Contains 3 EGF-like domains
    Similarity: Contains 1 ZP domain


    UMOD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UROM_HUMAN, P07911
    Function: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the
    thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like
    structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for
    cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial
    Function: Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may
    contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary
    tract infection and modulates formation of supersaturated salts and their crystals

         Genatlas biochemistry entry for UMOD:
    uromodulin,uromucoid,expressed in kidney,homolog to GP2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    UMOD for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UMOD:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Umod):
     adipose tissue  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     other  renal/urinary system  skeleton 

    UMOD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for UMOD: Umodtm1Xrw Umodtm1Kuma

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UMOD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UMOD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UMOD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UMOD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UMOD
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate UMOD:
    hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidUMOD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UMOD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UMOD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UMOD
    Sirion Biotech Customized adenovirus for overexpression of UMOD

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UMOD (see all 11)
    OriGene ORF clones in mouse, rat for UMOD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UMOD (NM_001008389)
    Sino Biological Human cDNA Clone for UMOD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UMOD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UMOD
    Sirion Biotech Customized lentivirus for stable overexpression of UMOD 
                         Customized lentivirus expression plasmids for stable overexpression of UMOD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UMOD
    Search LifeMap BioReagents cell lines for UMOD
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UMOD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UMOD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of HNF1
    Selected targets of HNF1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UMOD
        Selected targets of HNF1





    UMOD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UMOD

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for UMOD (P079113 ENSP000003062794) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LTAP013743, ENSP000004034954I2D: score=3 STRING: ENSP00000403495
    ENSG00000230279P013743I2D: score=3 
    ENSG00000231408P013743I2D: score=3 
    MMP8P228943, ENSP000002368264I2D: score=1 STRING: ENSP00000236826
    IL1BP015843I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS2409603
    GO:0007588excretion IEA--
    GO:0008285negative regulation of cell proliferation TAS2409603
    GO:0010033response to organic substance IEA--
    GO:0048878chemical homeostasis IEA--

    UMOD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UMOD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UMOD (UROM)

    10/29 Novoseek inferred chemical compound relationships for UMOD gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thps 90.1 8 17345077 (4), 7783702 (3)
    tamm 85.4 8 12900848 (2), 12270772 (1), 17065110 (1), 7490460 (1) (see all 6)
    calcium oxalate 82 55 7783702 (4), 10096372 (4), 12424489 (3), 15855216 (3) (see all 23)
    uric acid 64.5 15 16861244 (4), 11007825 (1), 12629136 (1), 17629875 (1) (see all 10)
    sialic acid 60.7 25 9352687 (4), 10460894 (3), 15637470 (2), 7664879 (1) (see all 13)
    oxalate 50.4 3 15327412 (1), 11007825 (1), 17629875 (1)
    creatinine 42.2 15 1488322 (1), 10572998 (1), 17616355 (1), 9650124 (1) (see all 10)
    citrate 38.4 20 7771027 (4), 10096372 (3), 8285211 (2), 17629875 (2) (see all 9)
    monosaccharide 37.8 3 10815984 (1), 10424459 (1)
    slex 36.7 3 10770931 (3)

    Search CenterWatch for drugs/clinical trials and news about UMOD / UROM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UMOD gene (3 alternative transcripts): 
    NM_001008389.2  NM_001278614.1  NM_003361.3  

    Unigene Cluster for UMOD:

    Uromodulin
    Hs.654425  [show with all ESTs]
    Unigene Representative Sequence: AK091961
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396134(uc002dhb.3) ENST00000396138(uc002dgz.3) ENST00000570689
    ENST00000570331 ENST00000573567 ENST00000571174 ENST00000577168 ENST00000574195
    ENST00000576688 ENST00000570757 ENST00000576546 ENST00000570972 ENST00000424589
    ENST00000302509(uc002dha.3) ENST00000396142
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UMOD
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate UMOD:
    hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidUMOD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UMOD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UMOD
    Clone
    Products:
         
    OriGene clones in human, mouse for UMOD (see all 11)
    OriGene ORF clones in mouse, rat for UMOD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UMOD (NM_001008389)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UMOD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UMOD
    Sirion Biotech Customized lentivirus for stable overexpression of UMOD 
                         Customized lentivirus expression plasmids for stable overexpression of UMOD 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UMOD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UMOD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UMOD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UMOD

    Additional mRNA sequence: 

    AK055722.1 AK091961.1 AK096043.1 AK127643.1 AK127648.1 BC035975.1 M15881.1 M17778.1 

    24/37 DOTS entries (see all 37):

    DT.120685796  DT.120685823  DT.95264795  DT.100020311  DT.107035  DT.120685818  DT.120685769  DT.120685856 
    DT.120685831  DT.120685825  DT.102827271  DT.120685783  DT.120685802  DT.101981138  DT.120685846  DT.100020313 
    DT.100754194  DT.120685844  DT.120685826  DT.70100028  DT.120685837  DT.120685810  DT.120685835  DT.120685843 

    24/103 AceView cDNA sequences (see all 103):

    M15881 BG430266 AI733047 BG428950 AI934416 AI700894 BX089145 AI768450 
    AI284347 BE466514 BE463493 BX109279 BE501786 AK096043 AI791538 AI791536 
    AW051962 AI640530 BG401615 AI625807 BG400435 AK091961 AI928388 AI566001 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for UMOD (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8 ^ 9 ^ 10 ^
    SP1:                                                                          -                                                                                 
    SP2:                                                              -     -     -                 -     -     -     -     -     -     -                           
    SP3:                                                              -     -     -                                                                                 
    SP4:                                                                                                                                                            
    SP5:                                            -                                                                                                               

    ExUns: 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:  -                                 
    SP2:  -                                 
    SP3:  -                                 
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for UMOD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UMOD expression in normal human tissues (normalized intensities)      UMOD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGTTCAG
    UMOD Expression
    About this image


    UMOD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 15 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
             Parietal epithelial cells (PEC)
             Renal-like cells ( Derivation of renal-like cells from mouse embryonic stem cells...
             kidney ; cells in tubules   
             visceral organ/metanephros/renal medulla   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 7 entries
             visceral organ   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Colon (Gastrointestinal Tract)
             colon ; glandular cells   

    See UMOD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UMOD

    SOURCE GeneReport for Unigene cluster: Hs.654425

    UniProtKB/Swiss-Prot: UROM_HUMAN, P07911
    Tissue specificity: Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick
    ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen. Most abundant protein in normal
    urine

        SABiosciences Expression via Pathway-Focused PCR Array including UMOD: 
              Terminal Differentiation Markers in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UMOD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UMOD
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UMOD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UMOD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UMOD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UMOD gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Umod1 , 5 uromodulin1, 5 79.31(n)1
    77.12(a)1
      7 (63.88 cM)5
    222421  NM_009470.41  NP_033496.11 
     1194628665 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    51(a)
    1 → many
    GL343621.1(77126-92542)


    ENSEMBL Gene Tree for UMOD (if available)
    TreeFam Gene Tree for UMOD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UMOD gene
    GP22  OIT32  
    13 SIMAP similar genes for UMOD using alignment to 11 protein entries:     UROM_HUMAN (see all proteins):
    GP2    DKFZp779K0533    UMODL1    FBN3    NELL2    SNED1
    LTBP1    FBLN2    PROS1    NOTCH2    MEGF6    CD97
    LTBP3

    UMOD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/646 SNPs in UMOD are shown (see all 646)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0259584
    Medullary cystic kidney disease 2 (MCKD2)4--see VAR_0259582 C W mis40--------
    VAR_0259594
    Familial juvenile hyperuricemic nephropathy 1 (HNFJ1)4--see VAR_0259592 C Y mis40--------
    VAR_0259524
    Familial juvenile hyperuricemic nephropathy 1 (HNFJ1)4--see VAR_0259522 C R mis40--------
    VAR_0259574
    Medullary cystic kidney disease 2 (MCKD2)4--see VAR_0259572 T K mis40--------
    VAR_0259604
    Familial juvenile hyperuricemic nephropathy 1 (HNFJ1)4--see VAR_0259602 C G mis40--------
    VAR_0259564
    Familial juvenile hyperuricemic nephropathy 1 (HNFJ1)4--see VAR_0259562 C Y mis40--------
    VAR_0259504
    Familial juvenile hyperuricemic nephropathy 1 (HNFJ1)4--see VAR_0259502 C Y mis40--------
    VAR_0259614
    Glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI)4--see VAR_0259612 C R mis40--------
    VAR_0259534
    Familial juvenile hyperuricemic nephropathy 1 (HNFJ1)4--see VAR_0259532 N S mis40--------
    rs289345831,2,4
    CFamilial juvenile hyperuricemic nephropathy 1 (HNFJ1)4 pathogenic120363175(-) AGACCC/TGCGTG 4 R C mis1 ese30--------

    HapMap Linkage Disequilibrium report for UMOD (20344373 - 20367623 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for UMOD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1759CNV Insertion18451855
    nsv436835CNV Insertion17901297


    Human Gene Mutation Database (HGMD): UMOD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UMOD
    DNA2.0 Custom Variant and Variant Library Synthesis for UMOD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191845   
    OMIM disorders: 162000  603860  609886  
    UniProtKB/Swiss-Prot: UROM_HUMAN, P07911
  • Familial juvenile hyperuricemic nephropathy 1 (HNFJ1) [MIM:162000]: A renal disease characterized by
    juvenile onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with
    interstitial pathological changes resulting in fibrosis. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Medullary cystic kidney disease 2 (MCKD2) [MIM:603860]: A form of tubulointerstitial nephropathy
    characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of
    impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]: A renal
    disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due
    to low fractional excretion of uric acid and severe impairment of urine concentrating ability. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 20/46 diseases for UMOD (see all 46):    About MalaCards
    familial juvenile hyperuricemic nephropathy    cystic kidney    hyperuricemia    umod-associated kidney disease
    bacteriuria    familial juvenile hyperuricaemic nephropathy    chronic pyelonephritis    pyelonephritis
    kidney disease    gout    cystitis    urinary tract obstruction
    vesicoureteral reflux    end stage renal failure    fibrous dysplasia    nephrolithiasis
    nephrocalcinosis    renal dysplasia    fabry disease    newcastle disease

    3 diseases from the University of Copenhagen DISEASES database for UMOD:
    Hyperuricemia     Gout     Kidney disease

    UMOD for disorders           About GeneDecksing

    10/45 Novoseek inferred disease relationships for UMOD gene (see all 45)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperuricemic nephropathy, familial juvenile 97.6 35 15983957 (2), 18409514 (1), 12900848 (1), 19203555 (1) (see all 20)
    medullary cystic kidney 95.7 25 15983957 (2), 11730273 (2), 12900848 (1), 12839032 (1) (see all 13)
    cystic kidney disease 87.4 23 15983957 (2), 11730273 (2), 20172860 (2), 12900848 (1) (see all 11)
    hyperuricaemic nephropathy 85.5 8 15589826 (2), 19465746 (2), 15575003 (1), 18651238 (1)
    hyperuricemia 84.7 16 20151160 (2), 18409531 (2), 16861244 (1), 17065110 (1) (see all 11)
    gout 76.2 6 20151160 (1), 17065110 (1), 19203555 (1), 16582687 (1)
    renal stone 71.3 19 11007825 (2), 19145410 (2), 9352687 (1), 2008908 (1) (see all 12)
    renal disease 66.6 58 8558842 (3), 20075439 (2), 11953407 (2), 15983957 (2) (see all 30)
    tubulointerstitial nephritis 57.7 1 14520616 (1)
    nephritis interstitial 57 3 10645146 (1), 10436264 (1), 15266028 (1)

    GeneTests: UMOD
    GeneReviews: UMOD
    Genetic Association Database (GAD): UMOD
    Human Genome Epidemiology (HuGE) Navigator: UMOD (12 documents)

    Export disorders for UMOD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UMOD gene, integrated from 9 sources (see all 266) (see top 10):
    (articles sorted by number of sources associating them with UMOD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Uromodulin is expressed in renal primary cilia and UM OD mutations result in decreased ciliary uromodulin expression. (PubMed id 20172860)1, 2, 9 Zaucke F....Wolf M.T. (2010)
    2. Mutations of the Uromodulin gene in MCKD type 2 patients cluster in exon 4, which encodes three EGF-like domains. (PubMed id 14531790)1, 2, 9 Wolf M.T.F.... Hildebrandt F. (2003)
    3. Uromodulin levels associate with a common UMOD varian t and risk for incident CKD. (PubMed id 19959715)1, 4, 9 KAPttgen A....Fox C.S. (2010)
    4. Uromodulin (Tamm-Horsfall glycoprotein/uromucoid) is a phosphatidylinositol-linked membrane protein. (PubMed id 2249987)1, 2, 9 Rindler M.J.... Peraldi M.-N. (1990)
    5. Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT). (PubMed id 18846391)1, 4, 9 Wolf M.T....Hildebrandt F. (2008)
    6. Allelism of MCKD, FJHN and GCKD caused by impairment of uromodulin export dynamics. (PubMed id 14570709)1, 2, 9 Rampoldi L.... Casari G. (2003)
    7. Renal manifestations of a mutation in the uromodulin (Tamm Horsfall protein) gene. (PubMed id 12900848)1, 2, 9 Bleyer A.J.... Hart T.C. (2003)
    8. UROMODULIN mutations cause familial juvenile hyperuricemic nephropathy. (PubMed id 12629136)1, 2, 9 Turner J.J.O.... Thakker R.V. (2003)
    9. Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass. (PubMed id 22087292)1, 4 Sun L....Deng H.W. (2011)
    10. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (2010)
    11. Association of variants at UMOD with chronic kidney d isease and kidney stones-role of age and comorbid diseases. (PubMed id 20686651)1, 4 Gudbjartsson D.F....Stefansson K. (2010)
    12. Tamm-Horsfall protein gene is associated with distal tubular dysfunction in patients with type 1 diabetes. (PubMed id 20624112)1, 4 MAPllsten A. and Torffvit O. (2010)
    13. Genome-wide association study of blood pressure extre mes identifies variant near UMOD associated with hypertension. (PubMed id 21082022)1, 4 Padmanabhan S....Dominiczak A.F. (2010)
    14. Prothrombin Haplotype Associated With Kidney Stone Di sease in Northeastern Thai Patients. (PubMed id 21067798)1, 4 Rungroj N....Yenchitsomanus P.T. (2010)
    15. Multiple loci associated with indices of renal function and chronic kidney disease. (PubMed id 19430482)1, 4 KAPttgen A....Fox C.S. (2009)
    16. Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage. (PubMed id 18375198)1, 2 Santambrogio S....Rampoldi L. (2008)
    17. Extensive genetic analysis of 10 candidate genes for hypertension in Japanese. (PubMed id 16982955)1, 4 Iwai N....Tomoike H. (2006)
    18. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    19. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    20. Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. (PubMed id 12471200)1, 2 Hart T.C.... Bleyer A.J. (2002)
    21. Chromosomal assignment of the uromodulin gene (UMOD) to 16p13.11. (PubMed id 8382593)1, 3 Jeanpierre C....Junien C. (1993)
    22. Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein. (PubMed id 3453112)1, 2 Pennica D.... Goeddel D.V. (1987)
    23. Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand for lymphokines. (PubMed id 3498215)1, 2 Hession C.... Muchmore A.V. (1987)
    24. Localization of Tamm-Horsfall glycoprotein in the human kidney using immuno-fluorescence and immuno-electron microscopical techniques. (PubMed id 7028707)1, 2 Sikri K.L.... Marshall R.D. (1981)
    25. Mutations in the uromodulin gene decrease urinary excretion of Tamm-Horsfall protein. (PubMed id 15327389)1, 9 Bleyer A.J....Hoyer J.R. (2004)
    26. A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. (PubMed id 14569098)1, 9 Dahan K....Pirson Y. (2003)
    27. Uromodulin mutations causing familial juvenile hyperu ricaemic nephropathy lead to protein maturation defects and retention in the en doplasmic reticulum. (PubMed id 19465746)1, 9 Williams S.E....Thakker R.V. (2009)
    28. Evidence for a role of uromodulin in chronic kidney d isease progression. (PubMed id 20075439)1, 9 Prajczer S....Jennings P. (2010)
    29. Abnormal expression and processing of uromodulin in Fabry disease reflects tubular cell storage alteration and is reversible by enzyme replacement therapy. (PubMed id 18651238)1, 9 Vylet'al P....Kmoch S. (2008)
    30. A novel pattern of mutation in uromodulin disorders: autosomal dominant medullary cystic kidney disease type 2, familial juvenile hyperuricemic nephropathy, and autosomal dominant glomerulocystic kidney disease. (PubMed id 15983957)1, 9 Lens X.M....Barrio-Lucia V. (2005)
    31. Defective intracellular trafficking of uromodulin mutant isoforms. (PubMed id 17010121)1, 9 Bernascone I....Rampoldi L. (2006)
    32. Immature renal structures associated with a novel UMOD sequence variant. (PubMed id 18950917)1, 9 Benetti E....Murer L. (2009)
    33. Membrane targeting and secretion of mutant uromodulin in familial juvenile hyperuricemic nephropathy. (PubMed id 17151335)1, 9 Jennings P....Pfaller W. (2007)
    34. Functional consequences of a novel uromodulin mutation in a family with familial juvenile hyperuricaemic nephropathy. (PubMed id 15575003)1, 9 Tinschert S....Rampoldi L. (2004)
    35. Effects of Tamm-Horsfall protein on polymorphonuclear leukocyte function. (PubMed id 15266028)1, 9 Wimmer T....Horl W.H. (2004)
    36. Molecular analysis of uromodulin and SAH genes, positional candidates for autosomal dominant medullary cystic kidney disease linked to 16p12. (PubMed id 11730273)1, 9 Pirulli D....Casari G. (2001)
    37. Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41. (PubMed id 16164624)1, 9 Hodanova K....Kmoch S. (2005)
    38. Familial juvenile hyperuricemic nephropathy: detection of mutations in the uromodulin gene in five Japanese families. (PubMed id 15086896)1, 9 Kudo E....Itakura M. (2004)
    39. Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin. (PubMed id 11932463)1, 9 Menozzi F.D....Raze D. (2002)
    40. Familial juvenile hyperuricemic nephropathy: report on a new mutation and a pregnancy. (PubMed id 19203555)1, 9 Lhotta K....Strazdins V. (2009)
    41. [Uromodulin mutation and hyperuricemia] (PubMed id 18409531)1, 9 Kudo E. and Itakura M. (2008)
    42. Intact protein core structure is essential for protein-binding, mononuclear cell proliferating, and neutrophil phagocytosis-enhancing activities of normal human urinary Tamm-Horsfall glycoprotein. (PubMed id 18068104)1, 9 Wu T.H....Yu C.L. (2008)
    43. Familial nephropathy associated with hyperuricemia in Spain: our experience with 3 families harbouring a UMOD mutation. (PubMed id 17065110)1, 9 Puig J.G....Torres R.J. (2006)
    44. Homozygosity for uromodulin disorders: FJHN and MCKD-type 2. (PubMed id 15253706)1, 9 Rezende-Lima W....Lens X.M. (2004)
    45. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PubMed id 15589826)1, 9 Yang H....Guo J. (2004)
    46. Variation of high mannose chains of Tamm-Horsfall glycoprotein confers differential binding to type 1-fimbriated Escherichia coli. (PubMed id 14570881)1, 9 Cavallone D....Serafini-Cessi F. (2004)
    47. Childhood course of renal insufficiency in a family w ith a uromodulin gene mutation. (PubMed id 20151160)1, 9 SchAoffer P....Bleyer A.J. (2010)
    48. [Familial juvenile hyperuricemic nephropathy (FJHN)] (PubMed id 18409515)1, 9 Kudo E. and Itakura M. (2008)
    49. Tubular function in diabetic children assessed by Tamm-Horsfall protein and glutathione S-transferase. (PubMed id 18351395)1, 9 Holmquist P. and Torffvit O. (2008)
    50. Altered glycosylation of Tamm-Horsfall glycoprotein derived from renal allograft recipients leads to changes in its biological function. (PubMed id 18047931)1, 9 Wu T.H....Tsai C.Y. (2008)
    51. Production and characterization of transgenic mice harboring mutant human UMOD gene. (PubMed id 18600511)1, 9 Takiue Y....Shibasaki T. (2008)
    52. The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect. (PubMed id 17245395)1, 9 Wolf M.T....Hildebrandt F. (2007)
    53. N-linked sugar chain structure of recombinant human lymphotoxin produced by CHO cells: the functional role of carbohydrate as to its lectin-like character and clearance velocity. (PubMed id 8323280)1, 9 Fukushima K....Yamashita K. (1993)
    54. Tamm-Horsfall protein-associated nucleotides in patien ts with interstitial cystitis. (PubMed id 23421394)1 Argade S....Parsons C.L. (2013)
    55. Association between genotype and phenotype in uromodul in-associated kidney disease. (PubMed id 23723338)1 Moskowitz J.L....Kotanko P. (2013)
    56. Common genetic variants of the human uromodulin gene r egulate transcription and predict plasma uric acid levels. (PubMed id 23344472)1 Han J....Wang H. (2013)
    57. Poor histological lesions in IgA nephropathy may be re flected in blood and urine peptide profiling. (PubMed id 23577616)1 Graterol F....Romero R. (2013)
    58. Common variants of the UMOD promoter associated with b lood pressure in a community-based Chinese cohort. (PubMed id 22592667)1 Han J....Wang H. (2012)
    59. Tamm-Horsfall protein facilitates catheter associated urinary tract infection. (PubMed id 23009031)1 Raffi H.S....Kumar S. (2012)
    60. Molecular and cellular effects of Tamm-Horsfall protei n mutations and their rescue by chemical chaperones. (PubMed id 22117067)1 Ma L....Wu X.R. (2012)
    61. A Japanese Family Suffering from Familial Juvenile Hyp eruricemic Nephropathy due to a Rare Mutation of the Uromodulin Gene. (PubMed id 23197950)1 Nakayama M....Taniguchi A. (2012)
    62. Association of estimated glomerular filtration rate an d urinary uromodulin concentrations with rare variants identified by UMOD gene r egion sequencing. (PubMed id 22693617)1 Kottgen A....Fox C.S. (2012)
    63. Urinary secretion and extracellular aggregation of mut ant uromodulin isoforms. (PubMed id 22237754)1 Schaeffer C....Rampoldi L. (2012)
    64. [Mutant uromodulin is secreted in the urine of patient s with familial hyperuricemic nephropathy and induces the formation of extracell ular aggregates]. (PubMed id 22538938)1 Schaeffer C....Rampoldi L. (2012)
    65. UMOD as a susceptibility gene for end-stage renal dise ase. (PubMed id 22947327)1 Reznichenko A....Navis G. (2012)
    66. The binding affinity and molecular basis of the struct ure-binding relationship between urinary Tamm-Horsfall glycoprotein and tumor ne crosis factor-a. (PubMed id 23060289)1 Wu C.H....Yu C.L. (2012)
    67. Novel uromodulin mutation in familial juvenile hyperur icemic nephropathy. (PubMed id 22776760)1 Wei X....Chen W. (2012)
    68. Uromodulin triggers IL-1b-dependent innate immunity vi a the NLRP3 inflammasome. (PubMed id 22997256)1 Darisipudi M.N....Anders H.J. (2012)
    69. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (2012)
    70. Detection of mutant uromodulin in transgenic mouse har boring a mutant human UMOD gene. (PubMed id 22132988)1 Yasuda M....Hosoyamada M. (2011)
    71. Uromodulin gene variant is associated with type 2 dia betic nephropathy. (PubMed id 21738052)1 Ahluwalia T.S....Melander O. (2011)
    72. Urinary UMOD excretion and chronic kidney disease in gout patients: cross-sectional case-control study. (PubMed id 21332338)1 Wu C.H....Chen C.J. (2011)
    73. Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function. (PubMed id 21081491)1 Renigunta A....Waldegger S. (2011)
    74. Scraping fibrosis: UMODulating renal fibrosis. (PubMed id 21546974)1 Eddy A.A. (2011)
    75. Phenotype and outcome in hereditary tubulointerstitia l nephritis secondary to UMOD mutations. (PubMed id 21868615)1 BollAce G....Knebelmann B. (2011)
    76. Enhancement of androgen action in the kidneys of tran sgenic mice harboring the mutant human UMOD gene. (PubMed id 21358122)1 Takiue Y....Saito H. (2011)
    77. Characterization of a recurrent in-frame UMOD indel mu tation causing late-onset autosomal dominant end-stage renal failure. (PubMed id 22034507)1 Smith G.D....Karet Frankl F.E. (2011)
    78. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (2011)
    79. Uromodulin facilitates neutrophil migration across renal epithelial monolayers. (PubMed id 20798515)2 Schmid M.... Joannidis M. (2010)
    80. Uromodulin biology and pathophysiology--an update. (PubMed id 21109754)1 Vyletal P....Kmoch S. (2010)
    81. Uromodulin and chronic kidney disease. (PubMed id 20948228)1 Lhotta K. (2010)
    82. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    83. A meta-analysis of genome-wide data from five Europea n isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creat inine level. (PubMed id 20222955)1 Pattaro C....Pramstaller P.P. (2010)
    84. Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. (PubMed id 18830570)1 Shen H.L....Han Z.G. (2009)
    85. Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects. (PubMed id 18455532)1 Canter M.P....Merchant M.L. (2008)
    86. Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys. (PubMed id 18025791)1 Trzpis M....Harmsen M.C. (2007)
    87. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    88. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    89. Donor specificity in the glycosylation of Tamm-Horsfall glycoprotein: conservation of the Sda determinant in pairs of twins. (PubMed id 15033942)1 Rohfritsch P.F....Kamerling J.P. (2004)
    90. [Benign epithelial cells and Tamm-Horsfall protein in lymph nodes from nephrectomy specimens with nephroblastoma: a diagnostic pitfall] (PubMed id 15785410)1 Boman F. and Boccon-Gibod L. (2004)
    91. Effects of Tamm-Horsfall protein on the protection of MCDK cells from oxalate induced free radical injury. (PubMed id 12624657)1 Hsieh N....Li C.W. (2003)
    92. Towards the identification of (a) gene(s) for autosomal dominant medullary cystic kidney disease. (PubMed id 12832729)1 Scolari F....Casari G. (2003)
    93. Uromodulin promoter directs high-level expression of biologically active human alpha1-antitrypsin into mouse urine. (PubMed id 11982485)1 Zbikowska H.M....Soukharev S. (2002)
    94. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    95. Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family. (PubMed id 10765940)1 Kamatani N....Itakura M. (2000)
    96. Glycosylation sites and site-specific glycosylation in human Tamm-Horsfall glycoprotein. (PubMed id 9884403)1 van Rooijen J.J....Vliegenthart J.F. (1999)
    97. Identification of a new locus for medullary cystic disease, on chromosome 16p12. (PubMed id 10330352)1 Scolari F....Casari G. (1999)
    98. Phylogeny of Tamm-Horsfall protein. (PubMed id 9873244)1 Badgett A. and Kumar S. (1998)
    99. Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine. (PubMed id 7873609)1 Prasadan K....Kumar S. (1995)
    100. Tamm Horsfall protein binds to a single class of carbohydrate specific receptors on human neutrophils. (PubMed id 8397318)1 Thomas D.B....Williams J.D. (1993)
    101. UMOD-Associated Kidney Disease (PubMed id 20301530)1 Bleyer A.J. and Hart P.S. (1993)
    102. Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women. (PubMed id 2409603)1 Muchmore A.V. and Decker J.M. (1985)
    103. A mucoprotein derived from human urine which reacts with influenza, mumps, and Newcastle disease viruses. (PubMed id 14907962)1 TAMM I. and HORSFALL F.L. (1952)
    104. Structural and functional modification of THP on nitration: comparison with stone formers THP. (PubMed id 15637470)9 Pragasam V....Varalakshmi P. (2005)
    105. Progressive accumulation of intrinsic mouse uromodulin in the kidneys of transgenic mice harboring the mutant human uromodulin gene. (PubMed id 18310901)9 Takiue Y....Shibasaki T. (2008)
    106. Tamm-Horsfall protein in bladder tissue. Morphologic spectrum and clinical significance. (PubMed id 8179076)9 Truong L.D....Wheeler T.M. (1994)
    107. Importance of carbohydrate in the interaction of Tamm-Horsfall protein with complement 1q and inhibition of classical complement activation. (PubMed id 16594900)9 Rhodes D.C. (2006)
    108. Analysis of the C-terminal structure of urinary Tamm-Horsfall protein reveals that the release of the glycosyl phosphatidylinositol-anchored counterpart from the kidney occurs by phenylalanine-specific proteolysis. (PubMed id 11741296)9 Fukuoka S. and Kobayashi K. (2001)
    109. Pregnancy-associated changes in the glycosylation of tamm-horsfall glycoprotein. Expression of sialyl Lewis(x) sequences on core 2 type O-glycans derived from uromodulin. (PubMed id 10770931)9 Easton R.L....Dell A. (2000)
    110. Tamm-Horsfall protein in urine after uninephrectomy/transplantation in kidney donors and their recipients. (PubMed id 9458515)9 Torffvit O....Strandgaard S. (1997)
    111. [Construction of urinary Tamm-Horsfall protein assay by enzyme-linked immunosorbent assay and establishment of reference range of healthy subject] (PubMed id 19068782)9 Nishimaki J....Shiba K. (2008)
    112. Identification of the scavenger receptors SREC-I, Cla-1 (SR-BI), and SR-AI as cellular receptors for Tamm-Horsfall protein. (PubMed id 17928461)9 Pfistershammer K....Steinberger P. (2008)
    113. Tamm-Horsfall protein in recurrent calcium kidney stone formers with positive family history: abnormalities in urinary excretion, molecular structure and function. (PubMed id 17345077)9 Jaggi M....Hess B. (2007)
    114. Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization. (PubMed id 12424489)9 Carvalho M....Nakagawa Y. (2002)
    115. Role of polymeric Tamm-Horsfall protein in cast formation: oligosaccharide and tubular fluid ions. (PubMed id 11231348)9 Wangsiripaisan A....Schrier R.W. (2001)
    116. Biochemical interaction between Tamm-Horsfall glycoprotein and Ig light chains in the pathogenesis of cast nephropathy. (PubMed id 8558842)9 Huang Z.Q. and Sanders P.W. (1995)
    117. Bence Jones proteins bind to a common peptide segment of Tamm-Horsfall glycoprotein to promote heterotypic aggregation. (PubMed id 8254051)9 Huang Z.Q....Sanders P.W. (1993)
    118. Urinary Tamm-Horsfall protein excretion in patients with primary vesicoureteral reflux. (PubMed id 1915538)9 Uto I....Kambara T. (1991)
    119. Role of sialic acid in urinary cytoprotective activity of Tamm-Horsfall protein. (PubMed id 17382182)9 Parsons C.L....Stein P. (2007)
    120. Beneficial effect of vitamin E supplementation on the biochemical and kinetic properties of Tamm-Horsfall glycoprotein in hypertensive and hyperoxaluric patients. (PubMed id 15855216)9 Sumitra K....Varalakshmi P. (2005)
    121. Polarized expression of Tamm-Horsfall protein by renal tubular epithelial cells activates human granulocytes. (PubMed id 11953407)9 Kreft B....van Zandbergen G. (2002)
    122. Urinary excretion of Tamm-Horsfall protein in normotensive, normo-albuminuric type 1 diabetic patients. (PubMed id 8852493)9 Catalano C. and Torffvit O. (1996)
    123. Tamm-Horsfall protein as a marker of tubular maturation. (PubMed id 8865241)9 Zimmerhackl L.B....Kinne R.K. (1996)
    124. Tamm-Horsfall protein: are serum levels a marker for urinary tract obstruction? (PubMed id 7696106)9 Johnstone L.M....Powell H.R. (1994)
    125. Immunological detection of nitrosative stress-mediated modified Tamm-Horsfall glycoprotein (THP) in calcium oxalate stone formers. (PubMed id 16766391)9 Pragasam V....Varalakshmi P. (2006)
    126. Uromodulin storage diseases: clinical aspects and mechanisms. (PubMed id 15558519)9 Scolari F....Ghiggeri G.M. (2004)
    127. Tamm-Horsfall glycoprotein: biology and clinical relevance. (PubMed id 14520616)9 Serafini-Cessi F....Cavallone D. (2003)
    128. Sequencing and radiation hybrid mapping of canine uromodulin. (PubMed id 12751332)9 Cox M.L....Murphy K.E. (2003)
    129. Conditions for solubilization of Tamm-Horsfall protein/uromodulin in human urine and establishment of a sensitive and accurate enzyme-linked immunosorbent assay (ELISA) method. (PubMed id 11361126)9 Kobayashi K. and Fukuoka S. (2001)
    130. Uromodulin and Tamm-Horsfall protein induce human monocytes to secrete TNF and express tissue factor. (PubMed id 9120306)9 Su S.J....Yeh T.M. (1997)
    131. Evaluation of nephrotoxicity with renal antigens in children: role of Tamm-Horsfall protein. (PubMed id 8486146)9 Zimmerhackl L.B. (1993)
    132. The interaction of Tamm-Horsfall protein with the extracellular matrix. (PubMed id 8344699)9 Lambert C....Rook G.A. (1993)
    133. Marked reduction of Tamm-Horsfall protein synthesis in hyperprostaglandin E-syndrome. (PubMed id 8377383)9 Schroter J....Bachmann S. (1993)
    134. Serum Tamm-Horsfall glycoprotein level in children with various renal diseases. (PubMed id 1758535)9 Yamamoto T....Maki S. (1991)
    135. N-Glycans carried by Tamm-Horsfall glycoprotein have a crucial role in the defense against urinary tract diseases. (PubMed id 16622944)9 Serafini-Cessi F....Cavallone D. (2005)
    136. Mechanism of release of urinary Tamm-Horsfall glycoprotein from the kidney GPI-anchored counterpart. (PubMed id 11162486)9 Cavallone D....Serafini-Cessi F. (2001)
    137. Urothelial cytoprotective activity of Tamm-Horsfall protein isolated from the urine of healthy subjects and patients with interstitial cystitis. (PubMed id 10830825)9 Akiyama A....Parsons C.L. (2000)
    138. Determinants of urinary excretion of Tamm-Horsfall protein in non-selected kidney stone formers and healthy subjects. (PubMed id 11007825)9 Glauser A....Hess B. (2000)
    139. Isoelectric focusing of native urinary uromodulin (Tamm-Horsfall protein) shows no physicochemical differences between stone formers and non-stone formers. (PubMed id 10460894)9 Trewick A.L. and Rumsby G. (1999)
    140. The sugar moiety of Tamm-Horsfall protein is affected by the carbohydrate-deficient glycoprotein type I syndrome. A case study. (PubMed id 10815984)9 Olczak T....Kubicz A. (1999)
    141. Composition of the sugar moiety of Tamm-Horsfall protein in patients with urinary diseases. (PubMed id 10436264)9 Olczak T....Kokot F. (1999)
    142. Tamm-Horsfall protein excretion and its relation to citrate in urine of stone-forming patients. (PubMed id 10096372)9 Ganter K....Hesse A. (1999)
    143. Coating in vitro of erythrocytes with Tamm Horsfall-protein. (PubMed id 9074814)9 Janssens P.M....Paardekooper J. (1997)
    144. Decreased Tamm-Horsfall protein in lithiasic patients. (PubMed id 9056112)9 Romero M.C....Nesse A.B. (1997)
    145. Tamm-Horsfall glycoprotein and calcium nephrolithiasis. (PubMed id 7783702)9 Hess B. (1994)
    146. Uromodulin levels are decreased in urine during acute tubular necrosis but not during immune rejection after renal transplantation. (PubMed id 8382589)9 McLaughlin P.J....Johnson P.M. (1993)
    147. Citrate and calcium effects on Tamm-Horsfall glycoprotein as a modifier of calcium oxalate crystal aggregation. (PubMed id 8285211)9 Hess B....Jaeger P. (1993)
    148. Determination of urinary Tamm-Horsfall protein by ELISA using a maleimide method for enzyme-antibody conjugation. (PubMed id 2019749)9 Uto I....Kambara T. (1991)
    149. Molecular abnormality of Tamm-Horsfall glycoprotein in calcium oxalate nephrolithiasis. (PubMed id 2012207)9 Hess B....Coe F.L. (1991)
    150. Abnormal glycosylation of Tamm-Horsfall protein in patients with interstitial cystitis. (PubMed id 19007360)9 Argade S.P....Parsons C.L. (2009)
    151. Alterations of uromodulin biology: a common denominator of the genetically heterogeneous FJHN/MCKD syndrome. (PubMed id 16883323)9 Vylet'al P....Kmoch S. (2006)
    152. Intravenous Tamm-Horsfall protein polyps: report of a case in association with a hematoma that mimicked a renal neoplasm. (PubMed id 17059985)9 Higgins J.P....Sibley R.K. (2006)
    153. Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis? (PubMed id 16861244)9 Gersch M.S....Johnson R.J. (2006)
    154. Tamm-Horsfall protein protects urothelial permeability barrier. (PubMed id 16230179)9 Stein P....Parsons C.L. (2005)
    155. The multiple functions of Tamm-Horsfall protein in human health and disease: a mystery clears up. (PubMed id 15989109)9 Weichhart T....Saemann M.D. (2005)
    156. Tamm-Horsfall protein in patients with kidney damage and diabetes. (PubMed id 15250099)9 Chakraborty J....Solaiman D. (2004)
    157. Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation. (PubMed id 15327412)9 Mo L....Wu X.R. (2004)
    158. Oligosaccharides released by hydrazinolysis from Tamm-Horsfall protein of various human donors contain similar high-mannose glycans. (PubMed id 10340432)9 Olczak M. and Olczak T. (1999)
    159. The abundance of additional N-acetyllactosamine units in N-linked tetraantennary oligosaccharides of human Tamm-Horsfall glycoprotein is a donor-specific feature. (PubMed id 9751793)9 van Rooijen J.J....Vliegenthart J.F. (1998)
    160. Effects of Tamm-Horsfall protein with normal and reduced sialic acid content upon the crystallization of calcium phosphate and calcium oxalate in human urine. (PubMed id 9352687)9 Hallson P.C....Samuell C.T. (1997)
    161. Urinary Tamm-Horsfall protein increased after potassium citrate therapy in calcium stone formers. (PubMed id 7771027)9 Fuselier H.A....Kok D.J. (1995)
    162. Urinary Tamm-Horsfall protein as a marker of renal tr ansplant function. (PubMed id 7992456)9 Kaden J....Liedvogel B. (1994)
    163. Uromodulin (Tamm-Horsfall protein) is a leukocyte adh esion molecule. (PubMed id 7513160)9 Toma G....Kumar S. (1994)
    164. The relationship between urinary Tamm-Horsfall glycoprotein excretion and urinary activity of glycosidases in normal pregnancy and pre-eclampsia. (PubMed id 8449258)9 Nesselhut T....Kuhn W. (1993)
    165. [Various methods for purification of urine Tamm-Horsfall protein] (PubMed id 2093062)9 Du Y....Liu X. (1990)
    166. Analysis of uromodulin polymerization provides new in sights into the mechanisms regulating ZP domain-mediated protein assembly. (PubMed id 19005207)9 Schaeffer C....Rampoldi L. (2009)
    167. Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors. (PubMed id 11134021)9 Pak J....Wu X.R. (2001)
    168. Early urinary changes in Tamm-Horsfall protein and epidermal growth factor in diabetic children. (PubMed id 11420912)9 Holmquist P....Sjoblad S. (2001)
    169. The patterns of the complex- and oligomannose-type glycans of uromodulin (Tamm-Horsfall glycoprotein) in the course of pregnancy. (PubMed id 12151715)9 Van Rooijen J.J....Vliegenthart J.F. (2001)
    170. Evaluation of urinary Tamm-Horsfall protein in post-menopausal diabetic women. (PubMed id 10616860)9 Below A.A....Haselhuhn G.D. (1999)
    171. Localization of a single binding site for immunoglobulin light chains on human Tamm-Horsfall glycoprotein. (PubMed id 9045877)9 Huang Z.Q. and Sanders P.W. (1997)
    172. [Clinical significance of determination of urinary albumin, beta 2 microglobulin and Tamm-Horsfall protein in diabetics] (PubMed id 1914672)9 Yu M. and Zhu Y.Q. (1991)
    173. Tumor necrosis factor in benign and malign tissue of the kidney. (PubMed id 1759331)9 Bichler K.H....Strohmaier W.L. (1991)
    174. Tamm-Horsfall-Protein excretion as a marker of ascending limb transport indicates early renal tubular damage in diabetes mellitus type I. (PubMed id 1722804)9 Zimmerhackl L.B....Brandis M. (1991)
    175. Characterization of a novel human corneal endothelial antigen. (PubMed id 1714428)9 Howell D.N....Sanfilippo F. (1991)
    176. Tamm-Horsfall protein-mRNA synthesis is localized to the thick ascending limb of Henle's loop in rat kidney. (PubMed id 2283315)9 Bachmann S....Bunnemann B. (1990)
    177. Proteomics and detection of uromodulin in first-time renal calculi patients and recurrent renal calculi patients. (PubMed id 19145410)9 Wai-Hoe L....Lay-Harn G. (2009)
    178. Decreased urinary concentration of Tamm-Horsfall protein is associated with development of renal failure and cardiovascular death within 20 years in type 1 but not in type 2 diabetic patients. (PubMed id 17907053)9 Sejdiu I. and Torffvit O. (2008)
    179. Comparison of urinary proteins in calcium stone formers and healthy individuals: a case-control study. (PubMed id 16493220)9 Pourmand G....Nourijelyani K. (2006)
    180. Germline hepatocyte nuclear factor 1alpha and 1beta mutations in renal cell carcinomas. (PubMed id 15649945)9 Rebouissou S....Zucman-Rossi J. (2005)
    181. The role of osteopontin on calcium oxalate crystal formation. (PubMed id 12706004)9 Konya E....Kurita T. (2003)
    182. [Urinary excretion of Tamm-Horsfall protein, albumin and beta-2 microglobulin in children with recurrent urinary tract infection] (PubMed id 11579828)9 Wolska-Duda I....Kokot F. (2001)
    183. Renal function in long-term survivors of stem cell transplantation in childhood. A prospective trial. (PubMed id 11277181)9 Patzer L....Misselwitz J. (2001)
    184. Which urinary proteins are decreased after angiotensin converting--enzyme inhibition? (PubMed id 9574449)9 Guidi E....Minetti E.E. (1998)
    185. Endothelin excretion during ketoacidosis does not correlate with tubular dysfunction. (PubMed id 7522505)9 MA!ttyus I....Tulassay T. (1994)
    186. Regulation of renal epithelial cell endocytosis of ca lcium oxalate monohydrate crystals. (PubMed id 8498532)9 Lieske J.C. and Toback F.G. (1993)
    187. The interaction between nephrocalcin and Tamm-Horsfall proteins with calcium oxalate dihydrate. (PubMed id 8146610)9 Deganello S. (1993)
    188. A GPI-anchored sea urchin sperm membrane protein containing EGF domains is related to human uromodulin. (PubMed id 8509450)9 Mendoza L.M....Vacquier V.D. (1993)
    189. Investigations on macromolecular precipitation inhibitors of calcium oxalate. (PubMed id 1736490)9 Schnierle P....Rutishauser G. (1992)
    190. Intrarenal reflux and nephropathy. (PubMed id 2192186)9 Shigematsu H. and Murakami S. (1990)
    191. Linking transcriptomic and proteomic data on the leve l of protein interaction networks. (PubMed id 20432478)9 Perco P....Mayer B. (2010)
    192. An aid to the diagnosis of genetic disorders underlyi ng adult-onset renal failure: a literature review. (PubMed id 20497759)9 Joosten H....Beukhof J.R. (2010)
    193. Thyroidization in renal allografts. (PubMed id 19594588)9 Ito S....Yamaguchi Y. (2009)
    194. Screening of vesicoureteral reflux in pediatric patie nts with kidney transplantation showing non-specific interstitial fibrosis and tubular atrophy with interstitial Tamm-Horsfall protein deposits in protocol al lograft biopsy. (PubMed id 19594587)9 Akioka Y....Hattori M. (2009)
    195. Urinary proteome pattern in children with renal Fanco ni syndrome. (PubMed id 19225019)9 Drube J....Ehrich J.H. (2009)
    196. Surface aggregation of urinary proteins and aspartic Acid-rich peptides on the faces of calcium oxalate monohydrate investigated by in situ force microscopy. (PubMed id 19294448)9 Weaver M.L....De Yoreo J.J. (2009)
    197. Low molecular weight proteins in urines from healthy subjects as well as diabetic, nephropathic and diabetic-nephropathic patients: a MALDI study. (PubMed id 19165811)9 Lapolla A....Traldi P. (2009)
    198. Nephronophthisis-like nephritis associated with fibrous dysplasia of bone. (PubMed id 18512082)9 Bacchetta J....Cochat P. (2008)
    199. Control of renal uric acid excretion and gout. (PubMed id 18349750)9 Taniguchi A. and Kamatani N. (2008)
    200. [Historical review of gout and hyperuricemia investigations] (PubMed id 18409506)9 Nakamura T. (2008)
    201. [Primary hyperuricemia due to decreased renal uric acid excretion] (PubMed id 18409514)9 Yamauchi T. and Ueda T. (2008)
    202. Early changes in glomerular size selectivity in young adults with type 1 diabetes and retinopathy. Results from the Diabetes Incidence Study in Sweden. (PubMed id 17616355)9 Torffvit O....Svensson M. (2007)
    203. Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome. (PubMed id 17494094)9 Vilasi A....Unwin R.J. (2007)
    204. Macrophage migration inhibitory factor is increased in the urine of patients with urinary tract infection: macrophage migration inhibitory factor-protein complexes in human urine. (PubMed id 16516040)9 Meyer-Siegler K.L....Vera P.L. (2006)
    205. Crystal-induced arthropathies: recent investigative advances. (PubMed id 16582687)9 Ellman M.H. and Becker M.A. (2006)
    206. Thirty-eight years of stone meetings in Europe. (PubMed id 16506036)9 Bichler K.H. (2006)
    207. Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1beta/MODY5 mutations. (PubMed id 16801329)9 Haumaitre C....Cereghini S. (2006)
    208. Is salt-wasting the long awaited answer to the hyperuricaemia seen in uromodulin storage diseases? (PubMed id 16421156)9 Gersch M....Johnson R. (2006)
    209. Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection. (PubMed id 15816991)9 Saemann M.D....Zlabinger G.J. (2005)
    210. Urinary Tamm-Horsfall protein and citrate: a case-control study of inhibitors and promoters of calcium stone formation. (PubMed id 17629875)9 Pourmand G....Shekarpour L. (2005)
    211. Clinico-pathologic findings in medullary cystic kidney disease type 2. (PubMed id 15844001)9 Bleyer A.J....Trachtman H. (2005)
    212. The ultrastructural basis of renal pathology in monoclonal gammopathies. (PubMed id 16358223)9 Santostefano M....Fusaroli M. (2005)
    213. Mutant tamm-horsfall glycoprotein accumulation in endoplasmic reticulum induces apoptosis reversed by colchicine and sodium 4-phenylbutyrate. (PubMed id 16135773)9 Choi S.W....Hart T.C. (2005)
    214. A novel heterozygous missense mutation in the UMOD gene responsible for Familial Juvenile Hyperuricemic Nephropathy. (PubMed id 15673476)9 Calado J....Rueff J. (2005)
    215. Analysis of urinary calculi obtained from a patient with idiopathic hypouricemia using micro area x-ray diffractometry and LC-MS. (PubMed id 16133578)9 Kaneko K....Fujimori S. (2005)
    216. Uric acid and the kidney: urate transport, stone disease and progressive renal failure. (PubMed id 16375737)9 Capasso G....Unwin R.J. (2005)
    217. Urinary excretion rate of Tamm-Horsfall protein is related to salt intake in humans. (PubMed id 15153749)9 Torffvit O....HultAcn U.L. (2004)
    218. Molecular analysis of uromodulin and SAH genes, positional candidates for autosomal dominant medullary cystic kidney disease linked to 16p12. (PubMed id 12839032)9 Casari G. and Amoroso A. (2003)
    219. Clinical characterization of a family with a mutation in the uromodulin (Tamm-Horsfall glycoprotein) gene. (PubMed id 12787393)9 Bleyer A.J....Hart T.C. (2003)
    220. Analysis of an expanded width of albumin fraction by cellulose acetate membrane electrophoresis in IgA nephropathy urine before treatment. (PubMed id 12640625)9 Machii R....Shiba K. (2003)
    221. Salt-precipitation method does not isolate to homogeneity Tamm-Horsfall glycoprotein from urine of proteinuric patients and pregnant women. (PubMed id 12270772)9 Cavallone D....Serafini-Cessi F. (2002)
    222. The use of the uromodulin promoter to target production of recombinant proteins into urine of transgenic animals. (PubMed id 12212844)9 Zbikowska H.M....Soukharev S. (2002)
    223. Tamm-Horsfall protein excretion to predict the onset of renal insufficiency. (PubMed id 11937080)9 Romero M.C....Nesse A. (2002)
    224. Low-grade tubular-mucinous renal neoplasms: morphologic, immunohistochemical, and genetic features. (PubMed id 12429795)9 Rakozy C....StAPrkel S. (2002)
    225. The relation of urinary Tamm-Horsfall-protein on CaOx-crystallization under the scope of the Bonn-Risk-Index. (PubMed id 11310215)9 Laube N....Hesse A. (2001)
    226. Exclusion mapping of major crystallization inhibitors in idiopathic calcium urolithiasis. (PubMed id 11547117)9 Cailhier J.F....Bonnardeaux A. (2001)
    227. Effects of Tamm-Horsfall protein and albumin on the inhibition of free radicals. (PubMed id 11741133)9 Chen W.C....Li C.W. (2001)
    228. Cyto-injury factors in urine: a possible mechanism fo r the development of interstitial cystitis. (PubMed id 10992419)9 Parsons C.L....Zupkas P. (2000)
    229. Changes in urine macromolecular composition during processing. (PubMed id 10840465)9 Maslamani S....Khan S.R. (2000)
    230. [Structure and function of Tamm-Horsfall protein in human physiologic and pathologic states] (PubMed id 10645146)9 Olczak T. (1999)
    231. Urinary sulphated glycosaminoglycans and Tamm-Horsfall protein in type 1 diabetic patients. (PubMed id 10572998)9 Torffvit O. (1999)
    232. Alterations of the sugar moiety of Tamm-Horsfall protein in children with malignancies of lymphoid cells. (PubMed id 10424459)9 Olczak T....Kubicz A. (1999)
    233. Changes in the surface conditioning of calcium-salt crystals treated with physiological and alkaline urine. (PubMed id 9698669)9 Santin M....Cannas M. (1998)
    234. Identification of proteins extracted from calcium oxalate and calcium phosphate crystals induced in the urine of healthy and stone forming subjects. (PubMed id 9694603)9 Atmani F....Khan S.R. (1998)
    235. Urinary excretion of Tamm-Horsfall protein and epidermal growth factor in chronic nephropathy. (PubMed id 9647496)9 Torffvit O....Strandgaard S. (1998)
    236. The nonselective adenosine antagonist theophylline does prevent renal dysfunction induced by radiographic contrast agents. (PubMed id 9650124)9 Kolonko A....Kokot F. (1998)
    237. [Does a relationship exist between urinary excretion of Tamm-Horsfall protein and electrolytes in patients with diabetes type I and II without diabetic nephropathy?] (PubMed id 9508663)9 Waszczuk J....Bar A. (1997)
    238. Effect of insulin on systemic and renal handling of albumin in nondiabetic and NIDDM subjects. (PubMed id 9133557)9 Catalano C....Ferrannini E. (1997)
    239. Alterations of Tamm-Horsfall protein immunoreactivity after partial desialylation and deglycosylation. (PubMed id 9017164)9 Grabska T....DuA8awa J. (1996)
    240. [The significance of dynamic change of plasma endothelin level in epidemic hemorrhagic fever] (PubMed id 8582188)9 Yang B....Liu C. (1995)
    241. Abnormal function of renal tubules in patients with simple renal cysts. (PubMed id 8725031)9 Franek E....Myrta J. (1995)
    242. Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions. (PubMed id 7733317)9 Lieske J.C....Toback F.G. (1995)
    243. Native and/or asialo-Tamm-Horsfall glycoproteins Sd(a+) are important receptors for Triticum vulgaris (wheat germ) agglutinin and for three toxic lectins (abrin-a, ricin and mistletoe toxic lectin-I). (PubMed id 7664879)9 Wu A.M....Lin J.Y. (1995)
    244. Analysis of the soluble organic matrix of five morphologically different kidney stones. Evidence for a specific role of albumin in the constitution of the stone protein matrix. (PubMed id 7618235)9 Dussol B....Verdier J.M. (1995)
    245. Purification of a 92 kDa human immunostimulating glycoprotein obtained from the Tamm-Horsfall glycoprotein. (PubMed id 7490460)9 Fontan E....Fauve R.M. (1995)
    246. [Concentrations of B2-microglobulin and Tamm-Horsfall protein in cyst fluid and urinary excretion of these proteins in patients with simple renal cysts] (PubMed id 7800578)9 Franek E....Myrta J. (1994)
    247. Limitation of shock-wave-induced renal tubular dysfunction by nifedipine. (PubMed id 7511106)9 Strohmaier W.L....Bichler K.H. (1994)
    248. Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand. (PubMed id 8125301)9 Ge A.Z. and Butcher E.C. (1994)
    249. Tamm-Horsfall glycoprotein: role in inhibition and promotion of renal calcium oxalate stone formation studied with Fourier-transform infrared spectroscopy. (PubMed id 8070085)9 KnAPrle R....Rutishauser G. (1994)
    250. Zeta potential distribution on calcium oxalate crystal and Tamm-Horsfall protein surface analyzed with Doppler electrophoretic light scattering. (PubMed id 8015107)9 BoevAc E.R....SchrAPder F.H. (1994)
    251. [Biologic role of Tamm-Horsfall glycoprotein] (PubMed id 8139370)9 Vranes J. and Zagar Z. (1993)
    252. [A study of antigenic characterization of Tamm-Horsfall glycoprotein using monoclonal antibodies] (PubMed id 7686237)9 Yamamoto T....Maki S. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7369 HGNC: 12559 AceView: UMOD Ensembl:ENSG00000169344 euGenes: HUgn7369
    ECgene: UMOD H-InvDB: UMOD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UMOD Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/UMOD

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UMOD gene:
    Search GeneIP for patents involving UMOD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UMOD
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Purified and/or Recombinant UMOD Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for UMOD (Uromodulin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UMOD  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for UMOD   OriGene clones in human, mouse for UMOD  
     OriGene qSTAR qPCR primer pairs in human, mouse for UMOD   OriGene Purified Protein for UMOD  
     OriGene ORF clones in mouse, rat for UMOD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UMOD   OriGene Custom Protein Services for UMOD  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UMOD
     QIAGEN SeqTarget long-range PCR primers for resequencing UMOD
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UMOD
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UMOD
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UMOD
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UMOD
     GenScript Custom Purified and Recombinant Proteins Services for UMOD GenScript cDNA clones with any tag delivered in your preferred vector for UMOD
     GenScript Custom Assay Services for UMOD GenScript Custom Superior Antibodies Services for UMOD
     GenScript Custom overexpressing Cell Line Services for UMOD CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UMOD promoter
     Search Chromatin IP Primers for UMOD
     RT2 qPCR Primer Assay in human, mouse, rat UMOD
     GNC Network for UMOD
     SABiosciences PCR Arrays including human, mouse, rat UMOD
     Search Tocris compounds for UMOD (UROM)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for UMOD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UMOD antibodies
     UMOD proteins
     UMOD lysates
     Antibodies for UMOD
     See all of Abcam's Antibodies, Kits and Proteins for UMOD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UMOD




     Proteins for UMOD
     Antibodies for UMOD
     ELISAs for UMOD
     CLIAs for UMOD
     Search LifeMap BioReagents cell lines for UMOD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UMOD
     SwitchGear 3'UTR luciferase reporter plasmids for UMOD
     SwitchGear Promoter luciferase reporter plasmids for UMOD
     ThermoFisher Antibodies for UMOD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UMOD
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UMOD
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UMOD
    Customized:
     lentivirus for stable overexpression of UMOD
     lentivirus expression plasmids for stable overexpression of UMOD
     adenovirus for overexpression of UMOD
     LSBio Antibodies in human, mouse, rat for UMOD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UMOD gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4