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ULK4 Gene

protein-coding   GIFtS: 46
GCID: GC03M041265

Unc-51 Like Kinase 4

(Previous name: unc-51-like kinase 4 (C. elegans))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-51 Like Kinase 41 2     REC010352
Unc-51-Like Kinase 42 3     Serine/Threonine-Protein Kinase ULK42
Unc-51-Like Kinase 4 (C. Elegans)1     EC 2.7.11.13
FAM7C12     

External Ids:    HGNC: 157841   Entrez Gene: 549862   Ensembl: ENSG000001680387   UniProtKB: Q96C453   

Export aliases for ULK4 gene to outside databases

Previous GC identifer: GC03M041806


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ULK4 Gene:
ULK4 (unc-51 like kinase 4) is a protein-coding gene. Diseases associated with ULK4 include essential hypertension, and hypertension. GO annotations related to this gene include protein serine/threonine kinase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ULK4 gene promoter:
         Bach1   ER-alpha   RFX1   Tal-1   p300   CUTL1   E47   c-Ets-1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ULK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ULK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

ULK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULK4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M041265:  view genomic region     (about GC identifiers)

Start:
41,288,090 bp from pter      End:
42,003,922 bp from pter
Size:
715,833 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ULK4_HUMAN, Q96C45 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase ULK4  
Size: 1275 amino acids; 142442 Da
Sequence caution: Sequence=BAA91270.1; Type=Frameshift; Positions=489;
Secondary accessions: A6NF15 Q8IW79 Q9NWV6 Q9UF96

Explore the universe of human proteins at neXtProt for ULK4: NX_Q96C45

Explore proteomics data for ULK4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ULK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060356.2  
    ENSEMBL proteins: 
     ENSP00000301831   ENSP00000412187   ENSP00000401414   ENSP00000391849   ENSP00000399382  

    ULK4 Human Recombinant Protein Products:

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    Novus Biologicals ULK4 Proteins
    Novus Biologicals ULK4 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ULK4

    ULK4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ULK4 Antibodies
    Abcam antibodies for ULK4
    Cloud-Clone Corp. Antibodies for ULK4
    ThermoFisher Antibodies for ULK4
    LSBio Antibodies in human, mouse, rat for ULK4

    ULK4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ULK4
    Cloud-Clone Corp. CLIAs for ULK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: unc-51-like kinase 4 (C. elegans)
    Unc-51-like kinase (ULK) family

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q96C45

    ProtoNet protein and cluster: Q96C45

    UniProtKB/Swiss-Prot: ULK4_HUMAN, Q96C45
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily
    Similarity: Contains 5 HEAT repeats
    Similarity: Contains 1 protein kinase domain


    ULK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ULK4_HUMAN, Q96C45
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005488binding ----
    GO:0005524ATP binding IEA--
         
    ULK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ULK4:
     Increased G1 DNA content 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ulk4):
     cardiovascular system  craniofacial  growth/size/body  hearing/vestibular/ear  immune system 
     mortality/aging  nervous system  respiratory system 

    ULK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ulk4tm1Lex for ULK4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ULK4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ULK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ULK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ULK4

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ULK4

    Gene Editing
    Products:
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    Clone
    Products:
         
    OriGene clones in human, mouse for ULK4 (see all 7)
    OriGene ORF clones in mouse, rat for ULK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ULK4 (NM_017886)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ULK4
    Browse ESI BIO Cell Lines and PureStem Progenitors for ULK4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ULK4
    Interactions:

        Search GeneGlobe Interaction Network for ULK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ULK4 (ENSP000003018314) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC6ENSP000003340614STRING: ENSP00000334061
    PTCH1ENSP000003323534STRING: ENSP00000332353
    PTCH2ENSP000003612664STRING: ENSP00000361266
    DHHENSP000002669914STRING: ENSP00000266991
    IHHENSP000002957314STRING: ENSP00000295731
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003351epithelial cilium movement IEA--
    GO:0006468protein phosphorylation ----
    GO:0021591ventricular system development IEA--
    GO:0060271cilium morphogenesis IEA--

    ULK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ULK4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ULK4 gene: 
    NM_017886.2  

    Unigene Cluster for ULK4:

    Unc-51-like kinase 4 (C. elegans)
    Hs.656192  [show with all ESTs]
    Unigene Representative Sequence: NM_017886
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489118(uc003cku.4) ENST00000301831(uc003ckv.4 uc003ckw.2)
    ENST00000460406 ENST00000420927(uc003ckx.1) ENST00000481226 ENST00000484323
    ENST00000459802 ENST00000497684 ENST00000453224 ENST00000431379 ENST00000414606
    ENST00000460978
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ULK4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ULK4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ULK4
    Predesigned siRNA for gene silencing in human, mouse, rat ULK4
    Clone
    Products:
         
    OriGene clones in human, mouse for ULK4 (see all 7)
    OriGene ORF clones in mouse, rat for ULK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ULK4 (NM_017886)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ULK4
    OriGene qSTAR qPCR primer pairs in human, mouse for ULK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ULK4
      QuantiTect SYBR Green Assays in human, mouse, rat ULK4
      QuantiFast Probe-based Assays in human, mouse, rat ULK4

    Additional mRNA sequence: 

    AK000581.1 AK093396.1 AK304341.1 AL133104.1 BC014794.1 BC018795.1 BC040739.1 

    15 DOTS entries:

    DT.100752374  DT.100017479  DT.75100299  DT.412008  DT.200951  DT.91912761  DT.40300016  DT.40108926 
    DT.95316276  DT.97793559  DT.97812547  DT.86846656  DT.95191204  DT.99958265  DT.99959200 

    Selected AceView cDNA sequences (see all 67):

    AX748099 AA279223 AK093396 AW104403 BC040739 BC018795 AL133104 AI220424 
    BU619588 AI828638 AJ712425 AW504756 BU196245 AI367541 BM822363 BU183995 
    CD367458 AI873263 CB159433 AA844642 AW269917 AW173233 AW082370 AA058965 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ULK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCCTCCC
    ULK4 Expression
    About this image

    ULK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ULK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656192
        Custom PCR Arrays for ULK4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ULK4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ulk41 , 5 unc-51-like kinase 4 (C. elegans)5
    unc-51-like kinase 41
    79.61(n)1
    83.29(a)1
      9 (72.19 cM)5
    2090121  NM_177589.31  NP_808257.21 
     1209602685 
    chicken
    (Gallus gallus)
    Aves ULK41 unc-51-like kinase 4 (C. elegans) 73.29(n)
    70.77(a)
      420713  XM_418812.4  XP_418812.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    69(a)
    55(a)
    many → 1
    many → 1
    GL343224.1(1061566-1149146)
    GL343224.1(984929-996675)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ulk41 unc-51 like kinase 4 65.92(n)
    63.06(a)
      100127864  XM_002940722.2  XP_002940768.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5619251 serine/threonine-protein kinase ULK4-like 61.88(n)
    60.88(a)
      561925  XM_001921265.3  XP_001921300.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RUK1 RUK 43.76(n)
    31.27(a)
      831988  NM_121875.3  NP_197371.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g02594001 Os01g0259400 45.35(n)
    31.26(a)
      4326239  NM_001049174.1  NP_001042639.1 


    ENSEMBL Gene Tree for ULK4 (if available)
    TreeFam Gene Tree for ULK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ULK4 gene
    12 SIMAP similar genes for ULK4 using alignment to 2 protein entries:     ULK4_HUMAN (see all proteins):
    ULK3    CDK1    DAPK1    DAPK3    CDK17    DKFZp564L2416
    CDK16    CDK18    STK11    STK36    CAMK4    RPS6KA1

    ULK4 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ULK4
    PGOHUM00000246661 PGOHUM00000246727 PGOHUM00000247040 PGOHUM00000251202


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ULK4 (see all 15734)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474747931,2
    Cuntested141759313(+) GCCTGA/C/GAGTGG 2 P S mis10--------
    rs117166021,2
    C,F,H--41287657(+) ACCCAA/GTATTG 1 -- int114Minor allele frequency- G:0.29NS EA NA WA CSA 780
    rs98242121,2
    C,F,A,H--41287693(+) AGGAGG/TTTCTA 1 -- int115Minor allele frequency- T:0.06NS EA NA WA 1638
    rs1504729811,2
    --41287726(+) GCAGAC/TATGGG 1 -- int10--------
    rs1383379591,2
    --41287747(+) AGAAGC/TTGGGG 1 -- int10--------
    rs1845305031,2
    --41287943(+) CAGGTA/GAAAGG 1 -- int10--------
    rs1407524421,2
    --41287962(+) CAAGAA/GGCTCA 1 -- int10--------
    rs117130421,2
    C,F,A,H--41288004(+) TGCGGT/CTGGGA 1 -- int111Minor allele frequency- C:0.35NA WA CSA EA 373
    rs117090101,2
    C,F,A,H--41288060(+) GGAGAG/AATGCT 1 -- int19Minor allele frequency- A:0.32NA WA EA 370
    rs117089511,2
    C,F,A,H--41288064(+) AGATGC/TTCACA 1 -- int113Minor allele frequency- T:0.21EA NS NA WA CSA 642

    HapMap Linkage Disequilibrium report for ULK4 (41288090 - 41538090 bp, first 250kb of ULK4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ULK4 (see all 66):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725197CNV Deletion23290073
    esv2661159CNV Deletion23128226
    esv2725193CNV Deletion23290073
    esv2725198CNV Deletion23290073
    esv2421817CNV Deletion20811451
    esv2725192CNV Deletion23290073
    esv2677560CNV Deletion23128226
    esv2674392CNV Deletion23128226
    esv2666348CNV Deletion23128226
    esv2665824CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ULK4
    DNA2.0 Custom Variant and Variant Library Synthesis for ULK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for ULK4:    
    About MalaCards
    essential hypertension    hypertension    myeloma    multiple myeloma


    ULK4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ULK4
    Human Genome Epidemiology (HuGE) Navigator: ULK4 (4 documents)

    Export disorders for ULK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ULK4 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ULK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. (PubMed id 22120009)1, 4 Broderick P....Houlston R.S. (Nat. Genet. 2012)
    2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PubMed id 20414254)1, 4 Hong K.W....Oh B. (J. Hum. Genet. 2010)
    5. Genome-wide association study of blood pressure and hypertension. (PubMed id 19430479)1, 4 Levy D....van Duijn C.M. (Nat. Genet. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. (PubMed id 23972371)1 Franceschini N....Zhu X. (Am. J. Hum. Genet. 2013)
    10. The CCND1 c.870G&gt;A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. (PubMed id 23502783)1 Weinhold N....Hemminki K. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54986 HGNC: 15784 AceView: FLJ20574 Ensembl:ENSG00000168038 euGenes: HUgn54986
    ECgene: ULK4 H-InvDB: ULK4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ULK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ULK4 gene:
    Search GeneIP for patents involving ULK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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