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Aliases for ULK4 Gene

Aliases for ULK4 Gene

  • Unc-51 Like Kinase 4 2 3 5
  • Unc-51-Like Kinase 4 (C. Elegans) 2
  • Unc-51-Like Kinase 4 4
  • EC 4
  • REC01035 3
  • FAM7C1 3

External Ids for ULK4 Gene

Previous GeneCards Identifiers for ULK4 Gene

  • GC03M041806

Summaries for ULK4 Gene

GeneCards Summary for ULK4 Gene

ULK4 (Unc-51 Like Kinase 4) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK4 Gene

Genomics for ULK4 Gene

Regulatory Elements for ULK4 Gene

Enhancers for ULK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ULK4 on UCSC Golden Path with GeneCards custom track

Promoters for ULK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ULK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ULK4 Gene

41,239,987 bp from pter
41,962,887 bp from pter
722,901 bases
Minus strand

Genomic View for ULK4 Gene

Genes around ULK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK4 Gene

Proteins for ULK4 Gene

  • Protein details for ULK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase ULK4
    Protein Accession:
    Secondary Accessions:
    • A6NF15
    • Q8IW79
    • Q9NWV6
    • Q9UF96

    Protein attributes for ULK4 Gene

    1275 amino acids
    Molecular mass:
    142442 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91270.1; Type=Frameshift; Positions=489; Evidence={ECO:0000305};

neXtProt entry for ULK4 Gene

Proteomics data for ULK4 Gene at MOPED

Post-translational modifications for ULK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ULK4 Gene

No data available for DME Specific Peptides for ULK4 Gene

Domains & Families for ULK4 Gene

Gene Families for ULK4 Gene

Protein Domains for ULK4 Gene

Suggested Antigen Peptide Sequences for ULK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
  • Contains 5 HEAT repeats.
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
  • Contains 5 HEAT repeats.
genes like me logo Genes that share domains with ULK4: view

Function for ULK4 Gene

Molecular function for ULK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for ULK4 Gene

Gene Ontology (GO) - Molecular Function for ULK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with ULK4: view
genes like me logo Genes that share phenotypes with ULK4: view

Animal Models for ULK4 Gene

MGI Knock Outs for ULK4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ULK4

miRNA for ULK4 Gene

miRTarBase miRNAs that target ULK4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK4 Gene

Localization for ULK4 Gene

Subcellular locations from

Jensen Localization Image for ULK4 Gene COMPARTMENTS Subcellular localization image for ULK4 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ULK4 Gene

Pathways & Interactions for ULK4 Gene

SuperPathways for ULK4 Gene

No Data Available

Pathways by source for ULK4 Gene

1 GeneTex pathway for ULK4 Gene

Interacting Proteins for ULK4 Gene

Gene Ontology (GO) - Biological Process for ULK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0010975 regulation of neuron projection development IMP 24284070
GO:0043408 regulation of MAPK cascade IMP 24284070
GO:0046328 regulation of JNK cascade IMP 24284070
GO:2001222 regulation of neuron migration IMP 24284070
genes like me logo Genes that share ontologies with ULK4: view

No data available for SIGNOR curated interactions for ULK4 Gene

Drugs & Compounds for ULK4 Gene

No Compound Related Data Available

Transcripts for ULK4 Gene

Unigene Clusters for ULK4 Gene

Unc-51-like kinase 4 (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ULK4 Gene

No ASD Table

Relevant External Links for ULK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ULK4 Gene

mRNA expression in normal human tissues for ULK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULK4 Gene

This gene is overexpressed in Testis (x6.8), Cervix - Endocervix (x4.9), and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for ULK4 Gene

This gene is overexpressed in Testis (29.7), Heart (28.5), and Platelet (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULK4 Gene

SOURCE GeneReport for Unigene cluster for ULK4 Gene Hs.656192

genes like me logo Genes that share expression patterns with ULK4: view

Protein tissue co-expression partners for ULK4 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ULK4 Gene

Orthologs for ULK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ULK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ULK4 35
  • 88.04 (n)
  • 88.23 (a)
(Canis familiaris)
Mammalia ULK4 35
  • 89.64 (n)
  • 89.01 (a)
ULK4 36
  • 89 (a)
(Mus musculus)
Mammalia Ulk4 35
  • 79.61 (n)
  • 83.29 (a)
Ulk4 16
Ulk4 36
  • 83 (a)
(Pan troglodytes)
Mammalia ULK4 35
  • 99.27 (n)
  • 98.9 (a)
ULK4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ulk4 35
  • 78.07 (n)
  • 81.44 (a)
(Monodelphis domestica)
Mammalia ULK4 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
-- 36
  • 68 (a)
-- 36
  • 63 (a)
(Gallus gallus)
Aves ULK4 35
  • 73.29 (n)
  • 70.77 (a)
-- 36
  • 68 (a)
-- 36
  • 73 (a)
-- 36
  • 81 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
-- 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk4 35
  • 65.92 (n)
  • 63.06 (a)
(Danio rerio)
Actinopterygii LOC561925 35
  • 61.88 (n)
  • 60.88 (a)
ulk4 36
  • 57 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RUK 35
  • 43.76 (n)
  • 31.27 (a)
(Oryza sativa)
Liliopsida Os01g0259400 35
  • 45.35 (n)
  • 31.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for ULK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ULK4 Gene

Gene Tree for ULK4 (if available)
Gene Tree for ULK4 (if available)

Paralogs for ULK4 Gene

(12) SIMAP similar genes for ULK4 Gene using alignment to 2 proteins: Pseudogenes for ULK4 Gene

genes like me logo Genes that share paralogs with ULK4: view

No data available for Paralogs for ULK4 Gene

Variants for ULK4 Gene

Sequence variations from dbSNP and Humsavar for ULK4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1052501 - 41,883,906(-) ACACA(A/G)CTGAG nc-transcript-variant, reference, missense
rs3774372 - 41,835,922(+) TTAAT(C/T)TGCTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs17063572 - 41,819,463(+) CAGCC(A/G)AGGGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs4973986 - 41,800,224(+) CTGGG(A/C)CTGAG nc-transcript-variant, reference, missense
rs17215589 - 41,789,711(+) GGCAG(C/T)GAATA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ULK4 Gene

Variant ID Type Subtype PubMed ID
nsv521572 CNV Loss 19592680
nsv3779 CNV Loss 18451855
esv2725192 CNV Deletion 23290073
esv7348 CNV Loss 19470904
esv2669828 CNV Deletion 23128226
dgv1451e1 CNV Complex 17122850
nsv834670 CNV Gain 17160897
nsv822061 CNV Gain 20364138
nsv460512 CNV Loss 19166990
nsv526908 CNV Loss 19592680
esv2515231 OTHER Inversion 19546169
nsv436705 OTHER Inversion 17901297
esv34828 CNV Loss 17911159
nsv822062 CNV Loss 20364138
esv2672435 CNV Deletion 23128226
esv2677560 CNV Deletion 23128226
essv602 CNV CNV 17122850
nsv10264 CNV Loss 18304495
esv272163 CNV Insertion 20981092
esv269566 CNV Insertion 20981092
nsv460513 CNV Gain 19166990
nsv822063 CNV Gain 20364138
dgv5126n71 CNV Loss 21882294
nsv876721 CNV Loss 21882294
esv2725193 CNV Deletion 23290073
esv2665824 CNV Deletion 23128226
esv33980 CNV Loss 17666407
nsv876722 CNV Loss 21882294
esv25423 CNV Loss 19812545
nsv10265 CNV Loss 18304495
nsv822064 CNV Loss 20364138
esv2661159 CNV Deletion 23128226
nsv460514 CNV Loss 19166990
nsv876723 CNV Loss 21882294
nsv876724 CNV Loss 21882294
esv2674392 CNV Deletion 23128226
esv2725194 CNV Deletion 23290073
nsv822066 CNV Loss 20364138
dgv601n27 CNV Loss 19166990
nsv460518 CNV Loss 19166990
nsv876725 CNV Gain 21882294
nsv876726 CNV Loss 21882294
esv21465 CNV Loss 19812545
esv2612939 CNV Deletion 19546169
esv22080 CNV Loss 19812545
esv2421817 CNV Deletion 20811451
nsv441822 CNV CNV 18776908
nsv514148 CNV Loss 21397061
nsv876727 CNV Loss 21882294
nsv876728 CNV Gain+Loss 21882294
nsv876729 CNV Loss 21882294
esv2517592 CNV Deletion 19546169
esv2033492 CNV Deletion 18987734
esv2666348 CNV Deletion 23128226
esv23866 CNV Loss 19812545
esv2725195 CNV Deletion 23290073
esv27077 CNV Loss 19812545
esv2179832 CNV Deletion 18987734
nsv236421 CNV Loss 16902084
nsv470550 CNV Gain 18288195
nsv460519 CNV Gain 19166990
esv27477 CNV Gain 19812545
nsv3780 CNV Loss 18451855
esv2725197 CNV Deletion 23290073
esv2725198 CNV Deletion 23290073
nsv460520 CNV Gain 19166990

Variation tolerance for ULK4 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.07; 97.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULK4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK4 Gene

Disorders for ULK4 Gene

Relevant External Links for ULK4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ULK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK4 Gene

Publications for ULK4 Gene

  1. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. (PMID: 22120009) Broderick P. … Houlston R.S. (Nat. Genet. 2012) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions. (PMID: 24447338) Kudoh A. … Ryo A. (Retrovirology 2014) 3
  4. Single-nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma. (PMID: 22945773) Greenberg A.J. … Vachon C.M. (Leukemia 2013) 3
  5. The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. (PMID: 23502783) Weinhold N. … Hemminki K. (Nat. Genet. 2013) 3

Products for ULK4 Gene

Sources for ULK4 Gene