Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ULK4 Gene

Aliases for ULK4 Gene

  • Unc-51 Like Kinase 4 2 3 5
  • Serine/Threonine-Protein Kinase ULK4 3
  • Unc-51-Like Kinase 4 (C. Elegans) 2
  • Unc-51-Like Kinase 4 4
  • EC 2.7.11.1 4
  • REC01035 3
  • FAM7C1 3

External Ids for ULK4 Gene

Previous GeneCards Identifiers for ULK4 Gene

  • GC03M041806

Summaries for ULK4 Gene

Entrez Gene Summary for ULK4 Gene

  • This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016]

GeneCards Summary for ULK4 Gene

ULK4 (Unc-51 Like Kinase 4) is a Protein Coding gene. Diseases associated with ULK4 include Schizophrenia. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for ULK4 Gene

  • May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK4 Gene

Genomics for ULK4 Gene

Regulatory Elements for ULK4 Gene

Enhancers for ULK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F041960 1.2 FANTOM5 ENCODE 56.9 +1.1 1123 2.8 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ULK4 TRAK1 GC03M041957 PIR53651
GH03F041933 0.6 ENCODE 53.7 +29.5 29536 0.6 JUN CEBPG RFX5 ZNF366 SCRT2 RCOR1 TCF7L2 STAT1 HLF CEBPB ULK4 ENSG00000212145 RPL36P20 GC03M041899
GH03F041888 0.9 Ensembl ENCODE 53.1 +74.1 74065 0.7 TEAD4 ULK4 ENSG00000212145 GC03M041899 ENSG00000251986 GC03M041868
GH03F041794 1.1 ENCODE 36.8 +168.0 168010 1.7 MTA2 RNF2 ZBED1 JUNB GABPA GLIS1 IKZF1 EED TCF7 FOS ULK4 TRAK1 RN7SKP58 GC03P041823
GH03F041900 0.6 Ensembl 35.5 +62.5 62487 0.4 NCOR1 PBX2 MAFG PRDM10 PRDM1 ULK4 ENSG00000212145 GC03M041899 RPL36P20
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ULK4 on UCSC Golden Path with GeneCards custom track

Promoters for ULK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001361943 887 2001 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ULK4 Gene

Chromosome:
3
Start:
41,239,987 bp from pter
End:
41,962,887 bp from pter
Size:
722,901 bases
Orientation:
Minus strand

Genomic View for ULK4 Gene

Genes around ULK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK4 Gene

Proteins for ULK4 Gene

  • Protein details for ULK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C45-ULK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK4
    Protein Accession:
    Q96C45
    Secondary Accessions:
    • A6NF15
    • B3KSE5
    • B4E2M4
    • Q8IW79
    • Q9NWV6
    • Q9UF96

    Protein attributes for ULK4 Gene

    Size:
    1275 amino acids
    Molecular mass:
    142442 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91270.1; Type=Frameshift; Positions=489; Evidence={ECO:0000305}; Sequence=BAG52707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ULK4 Gene

Post-translational modifications for ULK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ULK4 Gene

Domains & Families for ULK4 Gene

Gene Families for ULK4 Gene

Protein Domains for ULK4 Gene

Suggested Antigen Peptide Sequences for ULK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C45

UniProtKB/Swiss-Prot:

ULK4_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
  • Contains 5 HEAT repeats.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Similarity:
  • Contains 5 HEAT repeats.
genes like me logo Genes that share domains with ULK4: view

Function for ULK4 Gene

Molecular function for ULK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.
UniProtKB/Swiss-Prot Induction:
Up-regulated during neuronal differentiation of neuroblastoma cells treated with all-trans or 9-cis retinoic acid.

Enzyme Numbers (IUBMB) for ULK4 Gene

Gene Ontology (GO) - Molecular Function for ULK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ULK4: view
genes like me logo Genes that share phenotypes with ULK4: view

Animal Models for ULK4 Gene

MGI Knock Outs for ULK4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ULK4

miRNA for ULK4 Gene

miRTarBase miRNAs that target ULK4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK4 Gene

Localization for ULK4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULK4 Gene COMPARTMENTS Subcellular localization image for ULK4 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ULK4 Gene

Pathways & Interactions for ULK4 Gene

SuperPathways for ULK4 Gene

No Data Available

Pathways by source for ULK4 Gene

1 GeneTex pathway for ULK4 Gene

Gene Ontology (GO) - Biological Process for ULK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 24284070
GO:0006468 protein phosphorylation IEA --
GO:0010975 regulation of neuron projection development IMP 24284070
GO:0016310 phosphorylation IEA --
GO:0043408 regulation of MAPK cascade IMP 24284070
genes like me logo Genes that share ontologies with ULK4: view

No data available for SIGNOR curated interactions for ULK4 Gene

Transcripts for ULK4 Gene

Unigene Clusters for ULK4 Gene

Unc-51-like kinase 4 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULK4 Gene

No ASD Table

Relevant External Links for ULK4 Gene

GeneLoc Exon Structure for
ULK4
ECgene alternative splicing isoforms for
ULK4

Expression for ULK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ULK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULK4 Gene

This gene is overexpressed in Testis (x6.8), Cervix - Endocervix (x4.9), and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for ULK4 Gene

This gene is overexpressed in Testis (29.7), Heart (28.5), and Platelet (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULK4 Gene



Protein tissue co-expression partners for ULK4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ULK4 Gene:

ULK4

SOURCE GeneReport for Unigene cluster for ULK4 Gene:

Hs.656192

mRNA Expression by UniProt/SwissProt for ULK4 Gene:

Q96C45-ULK4_HUMAN
Tissue specificity: Expressed in the brain, mainly in postmitotic neurons, including GABAergic neurons, but not in astrocytes (at protein level).
genes like me logo Genes that share expression patterns with ULK4: view

Primer Products

Orthologs for ULK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ULK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULK4 34 35
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia ULK4 34 35
  • 89.64 (n)
cow
(Bos Taurus)
Mammalia ULK4 34
  • 88.04 (n)
mouse
(Mus musculus)
Mammalia Ulk4 34 16 35
  • 79.61 (n)
rat
(Rattus norvegicus)
Mammalia Ulk4 34
  • 78.07 (n)
oppossum
(Monodelphis domestica)
Mammalia ULK4 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 81 (a)
OneToMany
ULK4 34
  • 73.29 (n)
-- 35
  • 73 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk4 34
  • 65.92 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC561925 34
  • 61.88 (n)
ulk4 35
  • 57 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons RUK 34
  • 43.76 (n)
rice
(Oryza sativa)
Liliopsida Os01g0259400 34
  • 45.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for ULK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ULK4 Gene

ENSEMBL:
Gene Tree for ULK4 (if available)
TreeFam:
Gene Tree for ULK4 (if available)

Paralogs for ULK4 Gene

No data available for Paralogs for ULK4 Gene

Variants for ULK4 Gene

Sequence variations from dbSNP and Humsavar for ULK4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs188590896 Likely benign 41,681,599(+) GTTCA(C/T)GAGTA nc-transcript-variant, reference, missense
rs199884004 Likely benign 41,715,287(+) AGGTC(A/G)AAATA nc-transcript-variant, reference, stop-gained
rs77615850 Likely benign 41,789,798(+) AATAA(C/T)ATTCT nc-transcript-variant, reference, missense
rs10048998 -- 41,305,613(+) agtgc(C/G)gagac intron-variant
rs10049003 -- 41,305,574(+) acaac(C/G)tccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ULK4 Gene

Variant ID Type Subtype PubMed ID
dgv2513n106 CNV deletion 24896259
dgv4723n100 CNV loss 25217958
dgv4724n100 CNV loss 25217958
dgv4725n100 CNV loss 25217958
dgv4726n100 CNV gain 25217958
dgv601n27 CNV loss 19166990
dgv8290n54 CNV loss 21841781
dgv8291n54 CNV loss 21841781
dgv8292n54 CNV loss 21841781
dgv8293n54 CNV loss 21841781
dgv8294n54 CNV loss 21841781
dgv8295n54 CNV gain 21841781
dgv8296n54 CNV gain 21841781
dgv8297n54 CNV gain 21841781
dgv887e214 CNV loss 21293372
dgv888e214 CNV loss 21293372
esv2033492 CNV deletion 18987734
esv21465 CNV loss 19812545
esv2179832 CNV deletion 18987734
esv22080 CNV loss 19812545
esv23866 CNV loss 19812545
esv2421817 CNV deletion 20811451
esv2515231 OTHER inversion 19546169
esv2517592 CNV deletion 19546169
esv25423 CNV loss 19812545
esv2612939 CNV deletion 19546169
esv2661159 CNV deletion 23128226
esv2665824 CNV deletion 23128226
esv2666348 CNV deletion 23128226
esv2669828 CNV deletion 23128226
esv2672435 CNV deletion 23128226
esv2674392 CNV deletion 23128226
esv2677560 CNV deletion 23128226
esv27077 CNV loss 19812545
esv2725192 CNV deletion 23290073
esv2725193 CNV deletion 23290073
esv2725194 CNV deletion 23290073
esv2725195 CNV deletion 23290073
esv2725197 CNV deletion 23290073
esv2725198 CNV deletion 23290073
esv27477 CNV gain 19812545
esv2759143 CNV loss 17122850
esv2760776 CNV gain 21179565
esv2760800 CNV loss 21179565
esv3305288 CNV mobile element insertion 20981092
esv3307889 CNV mobile element insertion 20981092
esv3335656 CNV insertion 20981092
esv3342303 CNV insertion 20981092
esv3355808 CNV insertion 20981092
esv33980 CNV loss 17666407
esv34828 CNV loss 17911159
esv3561785 CNV deletion 23714750
esv3561786 CNV deletion 23714750
esv3568711 CNV loss 25503493
esv3568712 CNV loss 25503493
esv3568713 CNV loss 25503493
esv3568714 CNV loss 25503493
esv3595966 CNV loss 21293372
esv3595968 CNV loss 21293372
esv3595969 CNV loss 21293372
esv3595973 CNV loss 21293372
esv3595976 CNV loss 21293372
esv3595979 CNV loss 21293372
esv3595981 CNV loss 21293372
esv3595983 CNV loss 21293372
esv3595984 CNV gain 21293372
esv3595987 CNV loss 21293372
esv3893686 CNV loss 25118596
esv3893687 CNV loss 25118596
esv3893688 CNV loss 25118596
esv3893689 CNV gain 25118596
esv7293 CNV gain 19470904
esv7348 CNV loss 19470904
nsv1000508 CNV loss 25217958
nsv1002077 CNV loss 25217958
nsv1002350 CNV loss 25217958
nsv1007549 CNV loss 25217958
nsv10264 CNV loss 18304495
nsv10265 CNV loss 18304495
nsv1072251 CNV deletion 25765185
nsv1074585 CNV deletion 25765185
nsv1114373 CNV deletion 24896259
nsv1125284 OTHER inversion 24896259
nsv1125293 OTHER inversion 24896259
nsv1131694 CNV deletion 24896259
nsv1131695 CNV deletion 24896259
nsv1131696 CNV deletion 24896259
nsv1136720 CNV deletion 24896259
nsv1144039 CNV deletion 24896259
nsv1151403 CNV deletion 26484159
nsv1160934 CNV deletion 26073780
nsv236421 CNV deletion 16902084
nsv3779 CNV deletion 18451855
nsv3780 CNV deletion 18451855
nsv436705 OTHER inversion 17901297
nsv441822 CNV loss 18776908
nsv460512 CNV loss 19166990
nsv460513 CNV gain 19166990
nsv460514 CNV loss 19166990
nsv460518 CNV loss 19166990
nsv460519 CNV gain 19166990
nsv460520 CNV gain 19166990
nsv470550 CNV gain 18288195
nsv514148 CNV loss 21397061
nsv521572 CNV loss 19592680
nsv526908 CNV loss 19592680
nsv590123 CNV gain 21841781
nsv590124 CNV loss 21841781
nsv590127 CNV loss 21841781
nsv590130 CNV loss 21841781
nsv590144 CNV loss 21841781
nsv822061 CNV gain 20364138
nsv822062 CNV loss 20364138
nsv822063 CNV gain 20364138
nsv822064 CNV loss 20364138
nsv822066 CNV loss 20364138
nsv834670 CNV gain 17160897
nsv955539 CNV deletion 24416366
nsv967005 CNV duplication 23825009

Variation tolerance for ULK4 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.07; 97.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULK4 Gene

Human Gene Mutation Database (HGMD)
ULK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ULK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK4 Gene

Disorders for ULK4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ULK4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search ULK4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ULK4_HUMAN
  • Note=Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia. {ECO:0000269 PubMed:24284070}.

Relevant External Links for ULK4

Genetic Association Database (GAD)
ULK4
Human Genome Epidemiology (HuGE) Navigator
ULK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULK4
genes like me logo Genes that share disorders with ULK4: view

No data available for Genatlas for ULK4 Gene

Publications for ULK4 Gene

  1. Recurrent deletions of ULK4 in schizophrenia: a novel gene crucial for neuritogenesis and neuronal motility. (PMID: 24284070) Lang B. … Shen S. (J. Cell. Sci. 2013) 3 4 64
  2. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. (PMID: 22120009) Broderick P. … Houlston R.S. (Nat. Genet. 2012) 3 46 64
  3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PMID: 20414254) Hong K.W. … Oh B. (J. Hum. Genet. 2010) 3 46 64

Products for ULK4 Gene

Sources for ULK4 Gene

Content
Loading form....