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Aliases for ULK4 Gene

Aliases for ULK4 Gene

  • Unc-51 Like Kinase 4 2 3
  • Unc-51-Like Kinase 4 3 4
  • Serine/Threonine-Protein Kinase ULK4 3
  • Unc-51-Like Kinase 4 (C. Elegans) 2
  • EC 2.7.11.1 4
  • REC01035 3
  • FAM7C1 3

External Ids for ULK4 Gene

Summaries for ULK4 Gene

GeneCards Summary for ULK4 Gene

ULK4 (Unc-51 Like Kinase 4) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK4 Gene

Genomics for ULK4 Gene

Genomic Location for ULK4 Gene

Start:
41,246,599 bp from pter
End:
41,962,504 bp from pter
Size:
715,906 bases
Orientation:
Minus strand

Genomic View for ULK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ULK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK4 Gene

Regulatory Elements for ULK4 Gene

Proteins for ULK4 Gene

  • Protein details for ULK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C45-ULK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK4
    Protein Accession:
    Q96C45
    Secondary Accessions:
    • A6NF15
    • Q8IW79
    • Q9NWV6
    • Q9UF96

    Protein attributes for ULK4 Gene

    Size:
    1275 amino acids
    Molecular mass:
    142442 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91270.1; Type=Frameshift; Positions=489; Evidence={ECO:0000305};

neXtProt entry for ULK4 Gene

Proteomics data for ULK4 Gene at MOPED

Post-translational modifications for ULK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ULK4 Gene

No data available for DME Specific Peptides for ULK4 Gene

Domains for ULK4 Gene

Protein Domains for ULK4 Gene

UniProtKB/Swiss-Prot:

ULK4_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive:
    • Q96C45
  • Contains 1 protein kinase domain.:
    • Q96C45
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.:
    • Q96C45
Similarity:
  • Contains 5 HEAT repeats.:
    • Q96C45
genes like me logo Genes that share domains with ULK4: view

Function for ULK4 Gene

Molecular function for ULK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for ULK4 Gene

Gene Ontology (GO) - Molecular Function for ULK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005488 binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ULK4: view
genes like me logo Genes that share phenotypes with ULK4: view

Animal Models for ULK4 Gene

MGI Knock Outs for ULK4:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ULK4 Gene

Localization for ULK4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULK4 Gene COMPARTMENTS Subcellular localization image for ULK4 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ULK4 Gene

Pathways for ULK4 Gene

SuperPathways for ULK4 Gene

No Data Available

Interacting Proteins for ULK4 Gene

Gene Ontology (GO) - Biological Process for ULK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 24284070
GO:0003351 epithelial cilium movement IEA --
GO:0006468 protein phosphorylation IEA --
GO:0010975 regulation of neuron projection development IMP 24284070
GO:0021591 ventricular system development IEA --
genes like me logo Genes that share ontologies with ULK4: view

No data available for Pathways by source for ULK4 Gene

Transcripts for ULK4 Gene

Unigene Clusters for ULK4 Gene

Unc-51-like kinase 4 (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ULK4 Gene

No ASD Table

Relevant External Links for ULK4 Gene

GeneLoc Exon Structure for
ULK4
ECgene alternative splicing isoforms for
ULK4

Expression for ULK4 Gene

mRNA expression in normal human tissues for ULK4 Gene

mRNA differential expression in normal tissues according to GTEx for ULK4 Gene

This gene is overexpressed in Testis (6.8), Cervix - Endocervix (4.9), and Heart - Atrial Appendage (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ULK4 Gene

SOURCE GeneReport for Unigene cluster for ULK4 Gene Hs.656192

genes like me logo Genes that share expressions with ULK4: view

Orthologs for ULK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ULK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULK4 36
  • 99.27 (n)
  • 98.9 (a)
ULK4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ULK4 36
  • 88.04 (n)
  • 88.23 (a)
dog
(Canis familiaris)
Mammalia ULK4 36
  • 89.64 (n)
  • 89.01 (a)
ULK4 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ulk4 36
  • 79.61 (n)
  • 83.29 (a)
Ulk4 16
Ulk4 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ULK4 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 57 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ulk4 36
  • 78.07 (n)
  • 81.44 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 68 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
ULK4 36
  • 73.29 (n)
  • 70.77 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 69 (a)
OneToMany
-- 37
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk4 36
  • 65.92 (n)
  • 63.06 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC561925 36
  • 61.88 (n)
  • 60.88 (a)
ulk4 37
  • 57 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons RUK 36
  • 43.76 (n)
  • 31.27 (a)
rice
(Oryza sativa)
Liliopsida Os01g0259400 36
  • 45.35 (n)
  • 31.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToOne
Species with no ortholog for ULK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ULK4 Gene

ENSEMBL:
Gene Tree for ULK4 (if available)
TreeFam:
Gene Tree for ULK4 (if available)

Paralogs for ULK4 Gene

Selected SIMAP similar genes for ULK4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ULK4 Gene

genes like me logo Genes that share paralogs with ULK4: view

No data available for Paralogs for ULK4 Gene

Variants for ULK4 Gene

Sequence variations from dbSNP and Humsavar for ULK4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs15178 -- 41,859,448(-) GCTAT(A/C)TCTTT intron-variant
rs729093 -- 41,353,341(+) TAACA(A/T)TCTGG intron-variant
rs731936 -- 41,419,859(+) GGCCA(C/G)GGGTG intron-variant
rs749931 -- 41,337,091(+) AGAGA(A/C)TACAT intron-variant
rs749932 -- 41,337,130(+) GGTCT(C/T)AGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ULK4 Gene

Variant ID Type Subtype PubMed ID
nsv521572 CNV Loss 19592680
nsv3779 CNV Loss 18451855
esv2725192 CNV Deletion 23290073
esv7348 CNV Loss 19470904
esv2669828 CNV Deletion 23128226
dgv1451e1 CNV Complex 17122850
nsv834670 CNV Gain 17160897
nsv822061 CNV Gain 20364138
nsv460512 CNV Loss 19166990
nsv526908 CNV Loss 19592680
esv2515231 OTHER Inversion 19546169
nsv436705 OTHER Inversion 17901297
esv34828 CNV Loss 17911159
nsv822062 CNV Loss 20364138
esv2672435 CNV Deletion 23128226
esv2677560 CNV Deletion 23128226
essv602 CNV CNV 17122850
nsv10264 CNV Loss 18304495
esv272163 CNV Insertion 20981092
esv269566 CNV Insertion 20981092
nsv460513 CNV Gain 19166990
nsv822063 CNV Gain 20364138
dgv5126n71 CNV Loss 21882294
nsv876721 CNV Loss 21882294
esv2725193 CNV Deletion 23290073
esv2665824 CNV Deletion 23128226
esv33980 CNV Loss 17666407
nsv876722 CNV Loss 21882294
esv25423 CNV Loss 19812545
nsv10265 CNV Loss 18304495
nsv822064 CNV Loss 20364138
esv2661159 CNV Deletion 23128226
nsv460514 CNV Loss 19166990
nsv876723 CNV Loss 21882294
nsv876724 CNV Loss 21882294
esv2674392 CNV Deletion 23128226
esv2725194 CNV Deletion 23290073
nsv822066 CNV Loss 20364138
dgv601n27 CNV Loss 19166990
nsv460518 CNV Loss 19166990
nsv876725 CNV Gain 21882294
nsv876726 CNV Loss 21882294
esv21465 CNV Loss 19812545
esv2612939 CNV Deletion 19546169
esv22080 CNV Loss 19812545
esv2421817 CNV Deletion 20811451
nsv441822 CNV CNV 18776908
nsv514148 CNV Loss 21397061
nsv876727 CNV Loss 21882294
nsv876728 CNV Gain+Loss 21882294
nsv876729 CNV Loss 21882294
esv2517592 CNV Deletion 19546169
esv2033492 CNV Deletion 18987734
esv2666348 CNV Deletion 23128226
esv23866 CNV Loss 19812545
esv2725195 CNV Deletion 23290073
esv27077 CNV Loss 19812545
esv2179832 CNV Deletion 18987734
nsv236421 CNV Loss 16902084
nsv470550 CNV Gain 18288195
nsv460519 CNV Gain 19166990
esv27477 CNV Gain 19812545
nsv3780 CNV Loss 18451855
esv2725197 CNV Deletion 23290073
esv2725198 CNV Deletion 23290073
nsv460520 CNV Gain 19166990

Relevant External Links for ULK4 Gene

HapMap Linkage Disequilibrium report
ULK4
Human Gene Mutation Database (HGMD)
ULK4

Disorders for ULK4 Gene

Relevant External Links for ULK4

Genetic Association Database (GAD)
ULK4
Human Genome Epidemiology (HuGE) Navigator
ULK4
genes like me logo Genes that share disorders with ULK4: view

No data available for UniProtKB/Swiss-Prot for ULK4 Gene

Publications for ULK4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association study of blood pressure and hypertension. (PMID: 19430479) Levy D. … van Duijn C.M. (Nat. Genet. 2009) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ULK4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ULK4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ULK4
    • Block miRNA regulation of ULK4 using miScript Target Protectors
    • Addgene plasmids for ULK4

    Sources for ULK4 Gene

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