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ULK3 Gene

protein-coding   GIFtS: 56
GCID: GC15M075128

Unc-51 Like Kinase 3

(Previous name: unc-51-like kinase 3 (C. elegans))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-51 Like Kinase 31 2
Unc-51-Like Kinase 3 (C. Elegans)1
Serine/Threonine-Protein Kinase ULK32
EC 2.7.11.13
Unc-51-Like Kinase 33

External Ids:    HGNC: 197031   Entrez Gene: 259892   Ensembl: ENSG000001404747   OMIM: 6134725   UniProtKB: Q6PHR23   

Export aliases for ULK3 gene to outside databases

Previous GC identifers: GC15M072916 GC15M051925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ULK3 Gene:
ULK3 (unc-51 like kinase 3) is a protein-coding gene. Diseases associated with ULK3 include chronic myeloid leukemia, and tonsillitis. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is PDIK1L.

UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2
Function: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and
autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU,
thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2
and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU,
autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation.
Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of
autophagy: following cellular senescence, able to induce autophagy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ULK3 gene promoter:
         Egr-3   C/EBPalpha   Arnt   AREB6   MZF-1   CHOP-10   HEN1   POU2F1   POU2F1a   LyF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ULK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ULK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

ULK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULK3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075128:  view genomic region     (about GC identifiers)

Start:
75,128,457 bp from pter      End:
75,135,687 bp from pter
Size:
7,231 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase ULK3  
Size: 472 amino acids; 53444 Da
Subunit: Interacts (via protein kinase domain) with SUFU
Sequence caution: Sequence=CAB55955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RXK3 B4DRQ7 D3DW68 Q9NPN5 Q9UFS4
Alternative splicing: 3 isoforms:  Q6PHR2-1   Q6PHR2-2   Q6PHR2-3   (May be due to competing donor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ULK3: NX_Q6PHR2

Explore proteomics data for ULK3 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU1
  • Ubiquitination2 at Lys345
  • Modification sites at PhosphoSitePlus

  • See ULK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001092906.2  NP_001271293.1  NP_001271294.1  

    ENSEMBL proteins: 
     ENSP00000400312   ENSP00000456051   ENSP00000454583   ENSP00000456296   ENSP00000455395  
     ENSP00000457853   ENSP00000457061   ENSP00000457983   ENSP00000457305   ENSP00000456510  
     ENSP00000455199  

    ULK3 Human Recombinant Protein Products:

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    Novus Biologicals ULK3 Proteins
    Novus Biologicals ULK3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ULK3

    ULK3 Antibody Products:

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    ULK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ULK3
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    Cloud-Clone Corp. ELISAs for ULK3
    Cloud-Clone Corp. CLIAs for ULK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: unc-51-like kinase 3 (C. elegans)
    Unc-51-like kinase (ULK) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q6PHR2

    ProtoNet protein and cluster: Q6PHR2

    UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily
    Similarity: Contains 2 MIT domains
    Similarity: Contains 1 protein kinase domain


    ULK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ULK3_HUMAN, Q6PHR2
    Function: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and
    autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU,
    thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2
    and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU,
    autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation.
    Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of
    autophagy: following cellular senescence, able to induce autophagy
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Up-regulated during senescence

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA19878745
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    ULK3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ULK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased S DNA content  Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ULK3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ULK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ULK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ULK3:
    hsa-mir-125b-5p (MIRT004992), hsa-mir-744-5p (MIRT037732)

    Block miRNA regulation of human, mouse, rat ULK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ULK3 (see all 15):
    hsa-miR-125a-5p hsa-miR-148b hsa-miR-1914* hsa-miR-1224-5p hsa-miR-152 hsa-miR-544b hsa-miR-629* hsa-miR-670
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ULK3
    Predesigned siRNA for gene silencing in human, mouse, rat ULK3

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ULK3 (NM_001099436)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ULK3_HUMAN, Q6PHR2: Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure TAS19279323
    GO:0005737cytoplasm IDA19878745
    GO:0016020membrane ----

    ULK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ULK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    2Insulin receptor signalling cascade
    TOR signaling0.32
    3Regulation of autophagy
    Regulation of autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ULK3
        TOR signaling


    2 Kegg Pathways  (Kegg details for ULK3):
        Regulation of autophagy
    mTOR signaling pathway


    ULK3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ULK3
    Interactions:

        Search GeneGlobe Interaction Network for ULK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for ULK3 (Q6PHR23 ENSP000004003124) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAG2Q9UGJ03I2D: score=1 
    MTORENSP000003545584STRING: ENSP00000354558
    MRPS35ENSP000000810294STRING: ENSP00000081029
    PFASENSP000003134904STRING: ENSP00000313490
    RAB3IPENSP000003680864STRING: ENSP00000368086
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006914autophagy TAS19279323
    GO:0009103lipopolysaccharide biosynthetic process ----
    GO:0045879negative regulation of smoothened signaling pathway IDA--
    GO:0045880positive regulation of smoothened signaling pathway IDA19878745

    ULK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ULK3

    2 HMDB Compounds for ULK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ULK3 gene (3 alternative transcripts): 
    NM_001099436.2  NM_001284364.1  NM_001284365.1  

    Unigene Cluster for ULK3:

    Unc-51-like kinase 3 (C. elegans)
    Hs.513034  [show with all ESTs]
    Unigene Representative Sequence: BC048289
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000440863(uc010ulq.1) ENST00000566479 ENST00000561725 ENST00000569437(uc010ulp.1 uc010ulr.1)
    ENST00000570276(uc010bkf.1 uc002ayv.2 uc010uls.1) ENST00000567472
    ENST00000568718 ENST00000568273 ENST00000568210 ENST00000566631 ENST00000565881
    ENST00000568667 ENST00000564029 ENST00000563301 ENST00000565011(uc010ult.1)
    ENST00000562395 ENST00000564767(uc010ulu.1) ENST00000565373
    miRNA
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    Block miRNA regulation of human, mouse, rat ULK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ULK3 (see all 15):
    hsa-miR-125a-5p hsa-miR-148b hsa-miR-1914* hsa-miR-1224-5p hsa-miR-152 hsa-miR-544b hsa-miR-629* hsa-miR-670
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ULK3
    Clone
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    OriGene clones in human, mouse for ULK3 (see all 8)
    OriGene ORF clones in mouse, rat for ULK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ULK3 (NM_001099436)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ULK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ULK3
      QuantiTect SYBR Green Assays in human, mouse, rat ULK3
      QuantiFast Probe-based Assays in human, mouse, rat ULK3

    Additional mRNA sequence: 

    AK075047.1 AK293181.1 AK293650.1 AK294241.1 AK294245.1 AK294251.1 AK298879.1 AK299380.1 
    AK316102.1 AL360256.1 BC048289.1 BC157884.1 

    11 DOTS entries:

    DT.116055  DT.95341818  DT.101981107  DT.86850391  DT.95341848  DT.99957595  DT.100753826  DT.121064476 
    DT.75153287  DT.95341823  DT.95341853 

    Selected AceView cDNA sequences (see all 228):

    T25085 BM797180 CR617200 AL117482 AW192924 BG682859 BM542781 AW675294 
    BQ927030 BM830042 CR614098 AL360256 BI858216 BM810438 BQ101168 BQ677292 
    AI741848 AA282629 BQ069537 AI559961 BQ278881 AI827376 F29641 BI829133 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ULK3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^
    SP1:                                -                                                                                                                           
    SP2:                                -                                                                                                                           
    SP3:                                -                                                                                                                           
    SP4:                                -                                                                                                                       -   
    SP5:                                                                                -     -                                                                     

    ExUns: 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:                                          
    SP2:                                          
    SP3:  -                                       
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for ULK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ULK3 expression in normal human tissues (normalized intensities)      ULK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACTTATG
    ULK3 Expression
    About this image


    ULK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ULK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ULK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513034

    UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2
    Tissue specificity: Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in
    brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach,
    thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in
    the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord

        Custom PCR Arrays for ULK3
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    QuantiFast Probe-based Assays in human, mouse, rat ULK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ULK3 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ulk31 , 5 unc-51-like kinase 3 (C. elegans)5
    unc-51-like kinase 31
    88.06(n)1
    94.07(a)1
      9 (31.09 cM)5
    717421  NM_027895.11  NP_082171.11 
     575894525 
    chicken
    (Gallus gallus)
    Aves ULK31 unc-51-like kinase 3 (C. elegans) 77.14(n)
    78.63(a)
      769780  XM_004943689.1  XP_004943746.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    84(a)
    77(a)
    1 ↔ many
    1 ↔ many
    GL343492.1(602001-609501)
    AAWZ02040870(53-6282)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.221222 Xenopus laevis transcribed sequence with moderate similarity more 73.22(n)    BX846576.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ulk31 unc-51-like kinase 3 (C. elegans) 68.45(n)
    71.79(a)
      100037316  NM_001089472.1  NP_001082941.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88661 CG8866 51.93(n)
    46(a)
      41112  NM_169265.1  NP_731331.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T07F12.46
    Protein T07F12.4 (T07F12.4) mRNA, complete cds
    25(a)
    many ↔ many
    X(4896602-4898170) WBGene00020324
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG16
    Protein ser/thr kinase required for vesicle format...
    16(a)
    1 → many
    VII(160065-162758) YGL180W


    ENSEMBL Gene Tree for ULK3 (if available)
    TreeFam Gene Tree for ULK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ULK3 gene
    PDIK1L2  ULK12  STK332  ULK22  STK352  
    Selected SIMAP similar genes for ULK3 using alignment to 9 protein entries:     ULK3_HUMAN (see all proteins) (see all similar genes):
    VPS4B    MARK4    CDK3    AURKA    STK32A    CDK1
    KIN27    AURKB    CHEK2    AURKC    BRSK2    CAMK1
    CDK7    PNCK    ULK2    ULK4    SIK3    MARK2

    ULK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ULK3 (see all 222)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143281391,2
    F--51934522(+) ATCCAG/AGTTAT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs789032611,2
    C,F--75127974(+) GTGTAC/TGTGGG 1 -- ds50011Minor allele frequency- T:0.04EA 120
    rs1144835621,2
    C,F--75127975(+) TGTACG/ATGGGG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1409075191,2
    --75128016(+) GGAAAG/TGGAGA 1 -- ds50010--------
    rs1448543781,2
    --75128068(+) CTTTCC/TTCCAG 1 -- ds50010--------
    rs1179759881,2
    C,F--75128145(+) GGTGAG/AACAGT 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1806848331,2
    --75128176(+) CATGGC/TGGAAG 1 -- ds50010--------
    rs1475362731,2
    C--75128239(+) CCACCA/GGTCGC 1 -- ds50010--------
    rs1859966631,2
    --75128310(+) CAGATA/GTGGCT 1 -- ds50010--------
    rs1402358311,2
    C--75128491(+) ATGAAC/TGATAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ULK3 (75128457 - 75135687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ULK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749887CNV Deletion23290073
    esv1231258CNV Deletion17803354
    nsv904380CNV Loss21882294
    nsv904382CNV Loss21882294
    nsv904381CNV Loss21882294
    nsv833055CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ULK3
    DNA2.0 Custom Variant and Variant Library Synthesis for ULK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613472    OMIM disorders: --

    9 diseases for ULK3:    About MalaCards
    chronic myeloid leukemia    tonsillitis    myeloid leukemia    hypertension
    malaria    leukemia    cerebritis    thyroiditis
    prostatitis


    ULK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ULK3
    Human Genome Epidemiology (HuGE) Navigator: ULK3 (6 documents)

    Export disorders for ULK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ULK3 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with ULK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (Circulation 2010)
    2. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. (PubMed id 20643644)1, 2 Maloverjan A....Kogerman P. (J. Biol. Chem. 2010)
    3. The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. (PubMed id 20959405)1, 4 Kim D.H....Lipton J.H. (Clin. Cancer Res. 2010)
    4. Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. (PubMed id 19878745)1, 2 Maloverjan A.... Osterlund T. (Exp. Cell Res. 2010)
    5. Genome-wide association study of blood pressure and hypertension. (PubMed id 19430479)1, 4 Levy D....van Duijn C.M. (Nat. Genet. 2009)
    6. Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia. (PubMed id 19141860)1, 4 Kim D.H....Lipton J.H. (Blood 2009)
    7. Autophagy mediates the mitotic senescence transition. (PubMed id 19279323)1, 2 Young A.R.... Narita M. (Genes Dev. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    10. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25989 HGNC: 19703 AceView: DKFZP434C131 Ensembl:ENSG00000140474 euGenes: HUgn25989
    ECgene: ULK3 Kegg: 25989 H-InvDB: ULK3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ULK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ULK3 gene:
    Search GeneIP for patents involving ULK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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