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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ULK3 Gene

protein-coding GIFtS: 54
GCID: GC15M075128

unc-51-like kinase 3 (C. elegans)

Explore 6 diseases affiliated with
ULK3 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Unc-51-Like Kinase 3 (C. Elegans)¹ ²
DKFZP434C131¹
FLJ90566¹
Serine/Threonine-Protein Kinase ULK3²
EC 2.7.11.1³
Unc-51-Like Kinase 3³

External Ids:	HGNC: 19703¹	Entrez Gene: 25989²	Ensembl: ENSG00000140474⁷	OMIM: 613472⁵	UniProtKB: Q6PHR2³

Export aliases for ULK3 gene to outside databases

Previous GC identifers: GC15M072916 GC15M051925

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2

Function: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.

Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating

the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively

regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation

of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and

GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce

autophagy

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ULK3 gene promoter:
Egr-3 C/EBPalpha Arnt AREB6 MZF-1 CHOP-10 HEN1 POU2F1 POU2F1a LyF-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ULK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1

ULK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULK3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M075128: view genomic region (about GC identifiers)

Start:	75,128,457 bp from pter	End:	75,135,687 bp from pter
Size:	7,231 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase ULK3

Size: 472 amino acids; 53444 Da

Subunit: Interacts (via protein kinase domain) with SUFU

Subcellular location: Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence

Sequence caution: Sequence=CAB55955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B2RXK3 B4DRQ7 D3DW68 Q9NPN5 Q9UFS4

Alternative splicing: 3 isoforms: Q6PHR2-1 Q6PHR2-2 Q6PHR2-3 (May be due to competing donor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ULK3: NX_Q6PHR2

Post-translational modifications:

Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6PHR2

ULK3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001092906.1

ENSEMBL proteins:

ENSP00000400312 ENSP00000456051 ENSP00000454583 ENSP00000456296 ENSP00000455395

ENSP00000457853 ENSP00000457061 ENSP00000457983 ENSP00000457305 ENSP00000456510

ENSP00000455199

Human Recombinant Protein Products:

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	Novus Biologicals ULK3 Proteins Novus Biologicals ULK3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ULK3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000407	pre-autophagosomal structure	TAS	19279323
GO:0005737	cytoplasm	IDA	19878745

ULK3 for ontologies About GeneDecksing

ULK3 Antibody Products:

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	Uscn ELISAs and CLIAs for ULK3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ULK3 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q6PHR2

ProtoNet protein and cluster: Q6PHR2

UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily

Similarity: Contains 2 MIT domains

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2

Function: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.

Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating

the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively

regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation

of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and

GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce

autophagy

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Induction: Up-regulated during senescence

Enzyme Number (IUBMB): EC 2.7.11.1¹

miRNA Products:		miRTarBase miRNAs that target ULK3: hsa-mir-125b (MIRT004992)

		OriGene 3'-UTR Clone: ULK3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ULK3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ULK3 (see all 15):
		hsa-miR-125a-5p hsa-miR-148b hsa-miR-1914* hsa-miR-1224-5p hsa-miR-152 hsa-miR-544b hsa-miR-629* hsa-miR-670

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULK3 OriGene shRNA RFP: ULK3 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULK3

Gene Editing
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DNA2.0 Custom Protein Engineering Service for ULK3

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULK3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULK3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IDA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

ULK3 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for ULK3:

Decreased focal adhesion (FA)

Decreased substrate adherent c

Increased S DNA content

Increased Salmonella enterica

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mTOR signalling

TOR signaling

0.33

Regulation of IFNA signaling

Regulation of autophagy

0.26

Development_CNTF receptor signaling

mTOR signaling pathway

0.22

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for ULK3

TOR signaling

2 Kegg Pathways (Kegg details for ULK3):

	Regulation of autophagy
	mTOR signaling pathway

ULK3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ULK3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for ULK3 (Q6PHR2³ ENSP00000400312⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKAG2	Q9UGJ0³	I2D: score=1
MTOR	ENSP00000354558⁴	STRING: ENSP00000354558

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006914	autophagy	TAS	19279323
GO:0045879	negative regulation of smoothened signaling pathway	IDA	--
GO:0045880	positive regulation of smoothened signaling pathway	IDA	--
GO:0046777	protein autophosphorylation	IDA	--
GO:0090398	cellular senescence	TAS	19279323

ULK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ULK3

2 HMDB Compounds for ULK3 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Search CenterWatch for drugs/clinical trials and news about ULK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ULK3 gene (2 alternative transcripts):

NM_015518.1 NM_001099436.1

Unigene Cluster for ULK3:

Unc-51-like kinase 3 (C. elegans)

Hs.513034 [show with all ESTs]

Unigene Representative Sequence: BC048289

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000440863(uc010ulq.1) ENST00000566479 ENST00000561725 ENST00000569437(uc010ulp.1 uc010ulr.1)

ENST00000570276(uc010bkf.1 uc002ayv.2 uc010uls.1) ENST00000567472

ENST00000568718 ENST00000568273 ENST00000568210 ENST00000566631 ENST00000565881

ENST00000568667 ENST00000564029 ENST00000563301 ENST00000565011(uc010ult.1)

ENST00000562395 ENST00000564767(uc010ulu.1) ENST00000565373

miRNA Products:		OriGene 3'-UTR Clone: ULK3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ULK3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ULK3 (see all 15):
		hsa-miR-125a-5p hsa-miR-148b hsa-miR-1914* hsa-miR-1224-5p hsa-miR-152 hsa-miR-544b hsa-miR-629* hsa-miR-670

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULK3 OriGene shRNA RFP: ULK3 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULK3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULK3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULK3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ULK3 (NM_001099436)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK3

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ULK3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULK3

Additional cDNA sequence:

AK075047.1 AK293181.1 AK293650.1 AK294241.1 AK294245.1 AK294251.1 AK298879.1 AK299380.1

AK316102.1 AL360256.1 BC048289.1 BC157884.1

11 DOTS entries:

DT.116055 DT.95341818 DT.101981107 DT.86850391 DT.95341848 DT.99957595 DT.100753826 DT.121064476

DT.75153287 DT.95341823 DT.95341853

24/228 AceView cDNA sequences (see all 228):

BI829133 BQ069537 CR614098 BI858216 AA282629 NM_015518 BG682859 BQ278881

BM810438 AI741848 AW675294 BQ216430 BC056423 BM797180 F29641 AI827376

BQ101168 BM542781 CR617200 BQ677292 AW192924 BX280652 T25085 AL117482

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ULK3 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12	^	13	^	14	^
SP1:											-
SP2:											-
SP3:											-
SP4:											-																																								-
SP5:																											-		-

ExUns:	15a	·	15b	^	16	^	17	^	18a	·	18b	·	18c
SP1:
SP2:
SP3:	-
SP4:
SP5:

ECgene alternative splicing isoforms for ULK3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ULK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCACTTATG

About this image

ULK3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ULK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ULK3

SOURCE GeneReport for Unigene cluster: Hs.513034

UniProtKB/Swiss-Prot: ULK3_HUMAN, Q6PHR2

Tissue specificity: Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain,

liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate

and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum,

olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord

SABiosciences Custom PCR Arrays for ULK3

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULK3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ULK3 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ULK3¹	unc-51-like kinase 3 (C. elegans)	77.14(n) 78.63(a)		769780 XM_003641806.1 XP_003641854.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	84(a) 81(a)	1 ↔ many 1 ↔ many	GL343492.1(602001-609439) AAWZ02040870(394-6249)
African clawed frog (Xenopus laevis)	Amphibia	Xl.22122²	Xenopus laevis transcribed sequence with moderate similarity more	73.22(n)		BX846576.1
zebrafish (Danio rerio)	Actinopterygii	ulk3¹	unc-51-like kinase 3 (C. elegans)	68.45(n) 71.79(a)		100037316 NM_001089472.1 NP_001082941.1
fruit fly (Drosophila melanogaster)	Insecta	CG8866¹	CG8866	51.85(n) 45.56(a)		41112 NM_169265.1 NP_731331.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G49180⁶ AT3G61960⁶ (see all 4)	protein kinase family protein (see all 4)	22(a) 21(a) (see all 4)	possible ortholog possible ortholog (see all 4)	1(18184654-18187529) 3(22941772-22945288)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	CAMK_CAMK_like_ULKh_APGy.3 - CAMK includes calcium... CAMK_CAMK_like_ULKh_APGy.1 - CAMK includes calcium... (see all 3)	36(a) 19(a) (see all 3)	possible ortholog possible ortholog (see all 3)	4(34904237-34906152) 3(1210677-1216859)

ENSEMBL Gene Tree for ULK3 (if available)
TreeFam Gene Tree for ULK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ULK3 gene

PDIK1L² STK36² ULK1² STK33² ULK2² STK35²

18/48 SIMAP similar genes for ULK3 using alignment to 9 protein entries: ULK3_HUMAN (see all proteins) (see all similar genes):

VPS4B MARK4 CDK3 AURKA STK32A KIN27

AURKB CHEK2 AURKC BRSK2 CAMK1 CDK7

PNCK ULK2 ULK4 MARK2 CCRK PRKAA1

ULK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78903261^1,2	C,F,	--	75127974(+)	`GTGTAC/TGTGGG`	1	--	ds500¹		1		EA	120
rs114483562^1,2	C,F,	--	75127975(+)	`TGTACG/ATGGGG`	1	--	ds500¹		1		WA	118
rs140907519^1,2		--	75128016(+)	`GGAAAG/TGGAGA`	1	--	ds500¹		0	--	--	--	--
rs144854378^1,2		--	75128068(+)	`CTTTCC/TTCCAG`	1	--	ds500¹		0	--	--	--	--
rs117975988^1,2	C,	--	75128145(+)	`GGTGAG/AACAGT`	1	--	ds500¹		1		EA	120
rs180684833^1,2		--	75128176(+)	`CATGGC/TGGAAG`	1	--	ds500¹		0	--	--	--	--
rs147536273^1,2		--	75128239(+)	`CCACCA/GGTCGC`	1	--	ds500¹		0	--	--	--	--
rs185996663^1,2		--	75128310(+)	`CAGATA/GTGGCT`	1	--	ds500¹		0	--	--	--	--
rs140235831^1,2		--	75128491(+)	`ATGAAC/TGATAC`	1	--	ut3¹		0	--	--	--	--
rs9210^1,2	C,F,A,H,	--	75128501(+)	`CTCTTC/TACACT`	1	--	ut3¹		25		MN NS EA NA WA CSA	2535

HapMap Linkage Disequilibrium report for ULK3 (75128457 - 75135687 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ULK3
1 Inversion: 37170

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ULK3 for disorders           About GeneDecksing

OMIM gene information: 613472    OMIM disorders: --

6 diseases for ULK3:    About MalaCards

chronic myeloid leukemia myeloid leukemia leukemia hypertension

prostatitis alcoholism

Human Genome Epidemiology (HuGE) Navigator: ULK3 (6 documents)

Export disorders for ULK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ULK3 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ULK3)

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world of online information

Dual function of UNC-51-like kinase 3 (Ulk3) in the S onic hedgehog signaling pathway. (PubMed id 20643644)^{1, 2} Maloverjan A....Kogerman P. (2010)
Identification of a novel serine/threonine kinase ULK 3 as a positive regulator of Hedgehog pathway. (PubMed id 19878745)^{1, 2} Maloverjan A....Osterlund T. (2010)
Autophagy mediates the mitotic senescence transition. (PubMed id 19279323)^{1, 2} Young A.R.... Narita M. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Genome-wide association analysis of coffee drinking su ggests association with CYP1A1/CYP1A2 and NRCAM. (PubMed id 21876539)¹ Amin N....van Duijn C.M. (2012)
Discovery and replication of novel blood pressure gen etic loci in the Women's Genome Health Study. (PubMed id 21045733)¹ Ho J.E....Chasman D.I. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Genetic variants in novel pathways influence blood pre ssure and cardiovascular disease risk. (PubMed id 21909115)¹ ....Johnson T. (2011)
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PubMed id 21490707)¹ Cornelis M.C....Caporaso N.E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25989	HGNC: 19703	AceView: DKFZP434C131	Ensembl:ENSG00000140474	euGenes: HUgn25989
ECgene: ULK3	Kegg: 25989	H-InvDB: ULK3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ULK3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ULK3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ULK3 gene:
Search GeneIP for patents involving ULK3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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unc-51-like kinase 3 (C. elegans)

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unc-51-like kinase 3 (C. elegans)

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