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Aliases for ULK3 Gene

Aliases for ULK3 Gene

  • Unc-51 Like Kinase 3 2 3 5
  • Unc-51-Like Kinase 3 (C. Elegans) 2
  • Unc-51-Like Kinase 3 4
  • EC 2.7.11.1 4

External Ids for ULK3 Gene

Previous GeneCards Identifiers for ULK3 Gene

  • GC15M072916
  • GC15M075128
  • GC15M051925

Summaries for ULK3 Gene

GeneCards Summary for ULK3 Gene

ULK3 (Unc-51 Like Kinase 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Hedgehog. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK1.

UniProtKB/Swiss-Prot for ULK3 Gene

  • Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK3 Gene

Genomics for ULK3 Gene

Regulatory Elements for ULK3 Gene

Promoters for ULK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ULK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ULK3 Gene

Chromosome:
15
Start:
74,836,116 bp from pter
End:
74,843,346 bp from pter
Size:
7,231 bases
Orientation:
Minus strand

Genomic View for ULK3 Gene

Genes around ULK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK3 Gene

Proteins for ULK3 Gene

  • Protein details for ULK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PHR2-ULK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK3
    Protein Accession:
    Q6PHR2
    Secondary Accessions:
    • B2RXK3
    • B4DFT0
    • B4DRQ7
    • D3DW68
    • Q9NPN5
    • Q9UFS4

    Protein attributes for ULK3 Gene

    Size:
    472 amino acids
    Molecular mass:
    53444 Da
    Quaternary structure:
    • Interacts (via protein kinase domain) with SUFU.
    SequenceCaution:
    • Sequence=CAB55955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ULK3 Gene

    Alternative splice isoforms for ULK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ULK3 Gene

Proteomics data for ULK3 Gene at MOPED

Post-translational modifications for ULK3 Gene

  • Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU.
  • Ubiquitination at Lys 345
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ULK3 Gene

Domains & Families for ULK3 Gene

Gene Families for ULK3 Gene

Suggested Antigen Peptide Sequences for ULK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PHR2

UniProtKB/Swiss-Prot:

ULK3_HUMAN :
  • Contains 2 MIT domains.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Domain:
  • Contains 2 MIT domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
genes like me logo Genes that share domains with ULK3: view

Function for ULK3 Gene

Molecular function for ULK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
UniProtKB/Swiss-Prot Induction:
Up-regulated during senescence.

Enzyme Numbers (IUBMB) for ULK3 Gene

genes like me logo Genes that share phenotypes with ULK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ULK3

miRNA for ULK3 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ULK3 Gene

Localization for ULK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULK3 Gene

Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULK3 Gene COMPARTMENTS Subcellular localization image for ULK3 gene
Compartment Confidence
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ULK3 Gene

Pathways & Interactions for ULK3 Gene

genes like me logo Genes that share pathways with ULK3: view

Pathways by source for ULK3 Gene

1 GeneTex pathway for ULK3 Gene
1 BioSystems pathway for ULK3 Gene

Interacting Proteins for ULK3 Gene

Gene Ontology (GO) - Biological Process for ULK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with ULK3: view

No data available for SIGNOR curated interactions for ULK3 Gene

Drugs & Compounds for ULK3 Gene

(2) Drugs for ULK3 Gene - From: HMDB and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for ULK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ULK3: view

Transcripts for ULK3 Gene

Unigene Clusters for ULK3 Gene

Unc-51-like kinase 3 (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ULK3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7: - - -
SP8: - -
SP9: -
SP10: - - -
SP11:
SP12: -

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ULK3 Gene

GeneLoc Exon Structure for
ULK3
ECgene alternative splicing isoforms for
ULK3

Expression for ULK3 Gene

mRNA expression in normal human tissues for ULK3 Gene

Protein differential expression in normal tissues from HIPED for ULK3 Gene

This gene is overexpressed in Cerebrospinal fluid (37.8) and Lung (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ULK3 Gene



SOURCE GeneReport for Unigene cluster for ULK3 Gene Hs.513034

mRNA Expression by UniProt/SwissProt for ULK3 Gene

Q6PHR2-ULK3_HUMAN
Tissue specificity: Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord.
genes like me logo Genes that share expression patterns with ULK3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ULK3 Gene

Orthologs for ULK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ULK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULK3 35
  • 99.08 (n)
  • 99.15 (a)
ULK3 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ULK3 36
  • 97 (a)
OneToOne
ULK3 35
  • 91.24 (n)
  • 97.25 (a)
dog
(Canis familiaris)
Mammalia ULK3 35
  • 90.58 (n)
  • 94.99 (a)
ULK3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ulk3 16
Ulk3 36
  • 94 (a)
OneToOne
Ulk3 35
  • 88.06 (n)
  • 94.07 (a)
oppossum
(Monodelphis domestica)
Mammalia ULK3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ulk3 35
  • 88.63 (n)
  • 94.7 (a)
chicken
(Gallus gallus)
Aves ULK3 36
  • 78 (a)
OneToOne
ULK3 35
  • 77.14 (n)
  • 78.63 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.22122 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk3 35
  • 68.14 (n)
  • 74.1 (a)
zebrafish
(Danio rerio)
Actinopterygii ulk3 36
  • 58 (a)
OneToOne
ulk3 35
  • 68.45 (n)
  • 71.79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000098 35
  • 55.53 (n)
  • 43.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8866 35
  • 51.93 (n)
  • 46 (a)
CG8866 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T07F12.4 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14602 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for ULK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ULK3 Gene

ENSEMBL:
Gene Tree for ULK3 (if available)
TreeFam:
Gene Tree for ULK3 (if available)

Paralogs for ULK3 Gene

Paralogs for ULK3 Gene

genes like me logo Genes that share paralogs with ULK3: view

Variants for ULK3 Gene

Sequence variations from dbSNP and Humsavar for ULK3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_057113 -
rs12898397 - 74,837,752(+) CCACC(C/T)TGACC intron-variant, nc-transcript-variant, reference, missense
rs2290572 -- 74,838,232(-) GGGCC(C/T)CTGGC intron-variant, downstream-variant-500B
rs2290573 -- 74,837,253(-) CCTCA(A/C/T)CCCCG intron-variant
rs2290574 -- 74,843,106(+) GCCAT(C/T)CCGGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ULK3 Gene

Variant ID Type Subtype PubMed ID
nsv904380 CNV Loss 21882294
nsv833055 CNV Loss 17160897
nsv904381 CNV Loss 21882294
esv2749887 CNV Deletion 23290073
nsv904382 CNV Loss 21882294
esv1231258 CNV Deletion 17803354

Variation tolerance for ULK3 Gene

Gene Damage Index Score: 10.26; 90.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULK3 Gene

HapMap Linkage Disequilibrium report
ULK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK3 Gene

Disorders for ULK3 Gene

Relevant External Links for ULK3

Genetic Association Database (GAD)
ULK3
Human Genome Epidemiology (HuGE) Navigator
ULK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULK3

No disorders were found for ULK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK3 Gene

Publications for ULK3 Gene

  1. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PMID: 20479155) Takeuchi F. … Kato N. (Circulation 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PMID: 23383273) Yu C.C. … Chow L.P. (PLoS ONE 2013) 3
  4. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ULK3 Gene

Sources for ULK3 Gene

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