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Aliases for ULK3 Gene

Aliases for ULK3 Gene

  • Unc-51 Like Kinase 3 2 3
  • Unc-51-Like Kinase 3 (C. Elegans) 2
  • Unc-51-Like Kinase 3 4
  • EC 2.7.11.1 4

External Ids for ULK3 Gene

Previous GeneCards Identifiers for ULK3 Gene

  • GC15M072916
  • GC15M075128
  • GC15M051925

Summaries for ULK3 Gene

GeneCards Summary for ULK3 Gene

ULK3 (Unc-51 Like Kinase 3) is a Protein Coding gene. Among its related pathways are Insulin receptor signalling cascade and Translation Insulin regulation of translation. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK33.

UniProtKB/Swiss-Prot for ULK3 Gene

  • Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK3 Gene

Genomics for ULK3 Gene

Regulatory Elements for ULK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ULK3 Gene

Start:
74,836,116 bp from pter
End:
74,843,346 bp from pter
Size:
7,231 bases
Orientation:
Minus strand

Genomic View for ULK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ULK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK3 Gene

Proteins for ULK3 Gene

  • Protein details for ULK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PHR2-ULK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK3
    Protein Accession:
    Q6PHR2
    Secondary Accessions:
    • B2RXK3
    • B4DFT0
    • B4DRQ7
    • D3DW68
    • Q9NPN5
    • Q9UFS4

    Protein attributes for ULK3 Gene

    Size:
    472 amino acids
    Molecular mass:
    53444 Da
    Quaternary structure:
    • Interacts (via protein kinase domain) with SUFU.
    SequenceCaution:
    • Sequence=CAB55955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ULK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ULK3 Gene

Proteomics data for ULK3 Gene at MOPED

Post-translational modifications for ULK3 Gene

  • Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU.
  • Ubiquitination at Lys345
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ULK3 Gene

Domains for ULK3 Gene

Suggested Antigen Peptide Sequences for ULK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PHR2

UniProtKB/Swiss-Prot:

ULK3_HUMAN :
  • Q6PHR2
Domain:
  • Contains 2 MIT domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
genes like me logo Genes that share domains with ULK3: view

Function for ULK3 Gene

Molecular function for ULK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
UniProtKB/Swiss-Prot Induction: Up-regulated during senescence.

Enzyme Numbers (IUBMB) for ULK3 Gene

Gene Ontology (GO) - Molecular Function for ULK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 19878745
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20643644
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ULK3: view
genes like me logo Genes that share phenotypes with ULK3: view

Animal Model Products

CRISPR Products

miRNA for ULK3 Gene

miRTarBase miRNAs that target ULK3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ULK3 Gene

Localization for ULK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULK3 Gene

Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULK3 Gene COMPARTMENTS Subcellular localization image for ULK3 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for ULK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure TAS 19279323
GO:0005737 cytoplasm IDA 19878745
GO:0005829 cytosol IBA --
GO:0016020 membrane IBA --
GO:0034273 ATG1/UKL1 signaling complex IBA --
genes like me logo Genes that share ontologies with ULK3: view

Pathways for ULK3 Gene

genes like me logo Genes that share pathways with ULK3: view

Pathways by source for ULK3 Gene

1 BioSystems pathway for ULK3 Gene
2 KEGG pathways for ULK3 Gene

Interacting Proteins for ULK3 Gene

Gene Ontology (GO) - Biological Process for ULK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0006468 protein phosphorylation --
GO:0006914 autophagy TAS 19279323
GO:0008152 metabolic process --
GO:0009103 lipopolysaccharide biosynthetic process --
genes like me logo Genes that share ontologies with ULK3: view

Compounds for ULK3 Gene

(2) HMDB Compounds for ULK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with ULK3: view

Transcripts for ULK3 Gene

Unigene Clusters for ULK3 Gene

Unc-51-like kinase 3 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ULK3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ULK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULK3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7: - - -
SP8: - -
SP9: -
SP10: - - -
SP11:
SP12: -

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ULK3 Gene

GeneLoc Exon Structure for
ULK3
ECgene alternative splicing isoforms for
ULK3

Expression for ULK3 Gene

mRNA expression in normal human tissues for ULK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ULK3 Gene

SOURCE GeneReport for Unigene cluster for ULK3 Gene Hs.513034

mRNA Expression by UniProt/SwissProt for ULK3 Gene

Q6PHR2-ULK3_HUMAN
Tissue specificity: Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord.
genes like me logo Genes that share expressions with ULK3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ULK3 Gene

Orthologs for ULK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ULK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULK3 35
  • 99.08 (n)
  • 99.15 (a)
ULK3 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ULK3 35
  • 91.24 (n)
  • 97.25 (a)
ULK3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ULK3 35
  • 90.58 (n)
  • 94.99 (a)
ULK3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ulk3 35
  • 88.06 (n)
  • 94.07 (a)
Ulk3 16
Ulk3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ULK3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ulk3 35
  • 88.63 (n)
  • 94.7 (a)
chicken
(Gallus gallus)
Aves ULK3 35
  • 77.14 (n)
  • 78.63 (a)
ULK3 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.22122 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk3 35
  • 68.14 (n)
  • 74.1 (a)
zebrafish
(Danio rerio)
Actinopterygii ulk3 35
  • 68.45 (n)
  • 71.79 (a)
ulk3 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000098 35
  • 55.53 (n)
  • 43.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8866 35
  • 51.93 (n)
  • 46 (a)
CG8866 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T07F12.4 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14602 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for ULK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ULK3 Gene

ENSEMBL:
Gene Tree for ULK3 (if available)
TreeFam:
Gene Tree for ULK3 (if available)

Paralogs for ULK3 Gene

Paralogs for ULK3 Gene

genes like me logo Genes that share paralogs with ULK3: view

Variants for ULK3 Gene

Sequence variations from dbSNP and Humsavar for ULK3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs9210 -- 74,836,160(+) CTCTT(C/T)ACACT utr-variant-3-prime, nc-transcript-variant
rs936227 -- 74,839,618(+) GCAAA(A/G)AAGTC synonymous-codon, reference, nc-transcript-variant
rs936228 -- 74,839,823(+) GGGAA(C/T)CTGAG intron-variant
rs936229 -- 74,839,978(+) CTCCT(A/G)GGAAG intron-variant
rs2290572 -- 74,838,232(-) GGGCC(C/T)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ULK3 Gene

Variant ID Type Subtype PubMed ID
nsv904380 CNV Loss 21882294
nsv833055 CNV Loss 17160897
nsv904381 CNV Loss 21882294
esv2749887 CNV Deletion 23290073
nsv904382 CNV Loss 21882294
esv1231258 CNV Deletion 17803354

Relevant External Links for ULK3 Gene

HapMap Linkage Disequilibrium report
ULK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK3 Gene

Disorders for ULK3 Gene

Relevant External Links for ULK3

Genetic Association Database (GAD)
ULK3
Human Genome Epidemiology (HuGE) Navigator
ULK3
genes like me logo Genes that share disorders with ULK3: view

No data available for UniProtKB/Swiss-Prot for ULK3 Gene

Publications for ULK3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia. (PMID: 19141860) Kim D.H. … Lipton J.H. (Blood 2009) 3 48
  3. Autophagy mediates the mitotic senescence transition. (PMID: 19279323) Young A.R. … Narita M. (Genes Dev. 2009) 3 4
  4. Genome-wide association study of blood pressure and hypertension. (PMID: 19430479) Levy D. … van Duijn C.M. (Nat. Genet. 2009) 3 48
  5. Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. (PMID: 19878745) Maloverjan A. … Osterlund T. (Exp. Cell Res. 2010) 3 4

Products for ULK3 Gene

  • Addgene plasmids for ULK3

Sources for ULK3 Gene

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