Aliases for ULK3 Gene
External Ids for ULK3 Gene
Previous GeneCards Identifiers for ULK3 Gene
GeneCards Summary for ULK3 Gene
ULK3 (Unc-51 Like Kinase 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Hedgehog. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK1.
UniProtKB/Swiss-Prot for ULK3 Gene
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.