Aliases for ULK2 Gene
Aliases for ULK2 Gene
External Ids for ULK2 Gene
- HGNC: 13480
- Entrez Gene: 9706
- Ensembl: ENSG00000083290
- OMIM: 608650
- UniProtKB: Q8IYT8
Previous GeneCards Identifiers for ULK2 Gene
- GC17M019848
- GC17M021314
- GC17M019578
- GC17M019836
- GC17M019839
- GC17M019614
- GC17M019674
- GC17M019053
Summaries for ULK2 Gene
-
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
GeneCards Summary for ULK2 Gene
ULK2 (Unc-51 Like Autophagy Activating Kinase 2) is a Protein Coding gene. Diseases associated with ULK2 include Cecal Disease. Among its related pathways are p53 Pathway (RnD) and Regulation of autophagy. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK3.
UniProtKB/Swiss-Prot for ULK2 Gene
-
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK2 Gene
Genomics for ULK2 Gene
Regulatory Elements for ULK2 Gene
Enhancers for ULK2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ULK2 on UCSC Golden Path with GeneCards custom track
Promoters for ULK2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around ULK2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ULK2 gene promoter:
Regulatory Element Products
Genomic Location for ULK2 Gene
- Chromosome:
- 17
- Start:
- 19,770,828 bp from pter
- End:
- 19,867,936 bp from pter
- Size:
- 97,109 bases
- Orientation:
- Minus strand
Genomic View for ULK2 Gene
Genes around ULK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by Ensembl
- 17p11.2 by Entrez Gene
- 17p11.2 by HGNC
ULK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ULK2 Gene
Proteins for ULK2 Gene
-
Protein details for ULK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYT8-ULK2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase ULK2
- Protein Accession:
- Q8IYT8
- A8MY69
- O75119
Protein attributes for ULK2 Gene
- Size:
- 1036 amino acids
- Molecular mass:
- 112694 Da
- Quaternary structure:
-
- Interacts with SYNGAP1 (By similarity). Component of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1/FIP200. Interacts (via C-terminus) with ATG13/KIAA0652. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR.
- SequenceCaution:
-
- Sequence=BAA31598.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for ULK2 Gene
Selected DME Specific Peptides for ULK2 Gene
Post-translational modifications for ULK2 Gene
- Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ULK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ULK2
- Invitrogen Antibodies for ULK2
- antibodies-online Antibodies for ULK2: See all 113
- GeneTex ULK2 antibody for ULK2
- GeneTex Dpm1 antibody for ULK2
-
Custom Antibody ServicesProSci Antibodies for ULK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ULK2
Protein Products
- EMD Millipore Purified and/or Recombinant ULK2 Protein
-
OriGene Purified Proteins for ULK2
- Search Origene for MassSpec and Protein Over-expression Lysates for ULK2
- Origene Custom Protein Services for ULK2
- antibodies-online Proteins for ULK2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ULK2
Assay Products
Domains & Families for ULK2 Gene
Gene Families for ULK2 Gene
- HGNC:
- IUPHAR :
Protein Domains for ULK2 Gene
Suggested Antigen Peptide Sequences for ULK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IYT8UniProtKB/Swiss-Prot:
ULK2_HUMAN :- The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
- Domain:
-
- The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
- Contains 1 protein kinase domain.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Function for ULK2 Gene
Molecular function for ULK2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Enzyme Numbers (IUBMB) for ULK2 Gene
- EC 2.7.11.1 63 4
- EC 2.7.11 63
Phenotypes for ULK2 Gene
- MGI mutant phenotypes for ULK2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ULK2:
-
- Increased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Increased G1 DNA content
- G0/1 arrest
- Transferrin accumulation in the perinuclear area
- Increased shRNA abundance (Z-score > 2)
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability of wild-type and TP53 knockout cells
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased viability
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
Animal Model Products
-
Taconic Biosciences Mouse Models for ULK2
-
ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
- Search ViGene Biosciences for ULK2
CRISPR Products
-
OriGene CRISPR knockouts for ULK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- GenScript: Design CRISPR guide RNA sequences for ULK2
miRNA for ULK2 Gene
- miRTarBase miRNAs that target ULK2
-
- hsa-mir-335-5p (MIRT016824)
- hsa-mir-2681-5p (MIRT076301)
- hsa-mir-6807-5p (MIRT495001)
- hsa-mir-4713-5p (MIRT641816)
- hsa-mir-2116-3p (MIRT641817)
- hsa-mir-532-3p (MIRT641818)
- hsa-mir-150-5p (MIRT641819)
- hsa-mir-6814-5p (MIRT641820)
- hsa-mir-3691-3p (MIRT641821)
- hsa-mir-1264 (MIRT641822)
- hsa-mir-302c-5p (MIRT651871)
- hsa-mir-3143 (MIRT651872)
- hsa-mir-6514-3p (MIRT674455)
- hsa-mir-24-3p (MIRT674456)
- hsa-mir-4284 (MIRT674457)
- hsa-mir-4743-5p (MIRT674458)
- hsa-mir-564 (MIRT674459)
- hsa-mir-1290 (MIRT674460)
- hsa-mir-6847-3p (MIRT674461)
- hsa-mir-6811-3p (MIRT674462)
- hsa-mir-214-5p (MIRT674463)
- hsa-mir-383-3p (MIRT674464)
- hsa-mir-3614-5p (MIRT674465)
- hsa-mir-541-5p (MIRT674466)
- hsa-mir-6842-5p (MIRT709348)
- hsa-mir-6848-3p (MIRT709349)
- hsa-mir-6843-3p (MIRT709350)
- hsa-mir-3127-5p (MIRT709351)
- hsa-mir-593-3p (MIRT709352)
- hsa-mir-323a-5p (MIRT709353)
- hsa-mir-4483 (MIRT709354)
- hsa-mir-1293 (MIRT709355)
- hsa-mir-4766-5p (MIRT709356)
- hsa-mir-4653-5p (MIRT709357)
- hsa-mir-3921 (MIRT709358)
- hsa-mir-301b-5p (MIRT709359)
- hsa-mir-301a-5p (MIRT709360)
- hsa-mir-146a-3p (MIRT709361)
- hsa-mir-6823-5p (MIRT709362)
- hsa-mir-33b-5p (MIRT725090)
miRNA Products
- Search ViGene Biosciences for ULK2
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
Clone Products
- OriGene clones in human for ULK2
- OriGene ORF clones in human,mouse,rat for ULK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ULK2
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
Flow Cytometry Products
No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK2 Gene
Localization for ULK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ULK2 Gene
- Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane.
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| vacuole | 2 |
| lysosome | 1 |
No data available for Gene Ontology (GO) - Cellular Components for ULK2 Gene
Pathways & Interactions for ULK2 Gene
More details on SuperPathways for ULK2| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of autophagy | ||
| 2 | Longevity regulating pathway - multiple species | ||
| 3 | Translation Insulin regulation of translation | ||
| 4 | p53 Pathway (RnD) | ||
| 5 | mTOR signalling |
.40
|
Pathways by source for ULK2 Gene
1 GeneTex pathway for ULK2 Gene
1 BioSystems pathway for ULK2 Gene
3 KEGG pathways for ULK2 Gene
2 R&D Systems pathways for ULK2 Gene
Interacting Proteins for ULK2 Gene
SIGNOR curated interactions for ULK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007409 | axonogenesis | IEA | -- |
| GO:0046777 | protein autophosphorylation | IDA | 18936157 |
| GO:0048675 | axon extension | IEA,IBA | -- |
Drugs & Compounds for ULK2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for ULK2 Gene
mRNA/cDNA for ULK2 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (176) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ULK2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ULK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- GenScript: Design CRISPR guide RNA sequences for ULK2
miRNA Products
- Search ViGene Biosciences for ULK2
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
Clone Products
- OriGene clones in human for ULK2
- OriGene ORF clones in human,mouse,rat for ULK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ULK2
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | · | 16c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: |
Expression for ULK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
This gene is overexpressed in Peripheral blood mononuclear cells (68.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULK2 Gene
SOURCE GeneReport for Unigene cluster for ULK2 Gene Hs.168762
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for ULK2
-
OriGene qPCR primer pairs for ULK2
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ULK2 Gene
Orthologs for ULK2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | ULK2 35 |
|
||
| ULK2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ulk2 35 |
|
||
| Ulk2 16 |
|
||||
| Ulk2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ULK2 35 |
|
||
| ULK2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ulk2 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ULK2 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ULK2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ULK2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ULK2 35 |
|
||
| ULK2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | ULK2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ulk2 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8048 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.16298 35 |
|
||
| ulk2 35 |
|
||||
| ulk2 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8866 37 |
|
|
|
| Atg1 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | unc-51 37 |
|
|
|
| unc-51 36 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATG1 36 |
|
OneToMany | |
| ATG1 38 |
|
|
- Species with no ortholog for ULK2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ULK2 Gene
(31) SIMAP similar genes for ULK2 Gene using alignment to 4 proteins:
Variants for ULK2 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs34670978 | - | 19,838,564(+) | ATAAG(A/G)TGATG | nc-transcript-variant, reference, missense | |
| VAR_041282 | A metastatic melanoma sample | ||||
| VAR_041283 | A metastatic melanoma sample | ||||
| rs55730189 | - | 19,783,903(+) | GGGCC(C/T)CACTA | nc-transcript-variant, reference, missense | |
| rs35107651 | - | 19,782,002(+) | GTCAG(G/T)TCCAG | intron-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3101n71 | CNV | Loss | 21882294 |
| nsv510435 | CNV | Loss | 20534489 |
| nsv2002 | CNV | Insertion | 18451855 |
| esv2649888 | CNV | Deletion | 19546169 |
| nsv907868 | CNV | Gain | 21882294 |
Residual Variation Intolerance Score:
9.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.52;
55.58% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ULK2 Gene
- Human Gene Mutation Database (HGMD)
- ULK2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK2 Gene
Disorders for ULK2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cecal disease |
|
|
Search ULK2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ULK2
No data available for UniProtKB/Swiss-Prot and Genatlas for ULK2 Gene
Publications for ULK2 Gene
- Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. (PMID: 10557072) Yan J. … Muramatsu M. (Oncogene 1999) 2 3 23 67
- Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy. (PMID: 25925668) Xu J. … McPherson P.S. (EMBO Rep. 2015) 3
- ULK2 Ser 1027 Phosphorylation by PKA Regulates Its Nuclear Localization Occurring through Karyopherin Beta 2 Recognition of a PY-NLS Motif. (PMID: 26052940) Shin S.H. … Kang S.S. (PLoS ONE 2015) 3
- Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth. (PMID: 24923441) Shukla S. … Somasundaram K. (J. Biol. Chem. 2014) 3
- ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PMID: 23043107) Alemu E.A. … Johansen T. (J. Biol. Chem. 2012) 3
Products for ULK2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ULK2
- Search Origene for MassSpec and Protein Over-expression Lysates for ULK2
- Origene Custom Protein Services for ULK2
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
- OriGene qPCR primer pairs for ULK2
- OriGene qPCR primer pairs and template standards for ULK2
- OriGene CRISPR knockouts for ULK2
- OriGene clones in human for ULK2
- OriGene ORF clones in human,mouse,rat for ULK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for ULK2
- GenScript Custom Assay Services for ULK2
- GenScript Custom overexpressing Cell Line Services for ULK2
- GenScript: Design CRISPR guide RNA sequences for ULK2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ULK2
- Novus Biologicals Antibodies for ULK2
- Novus Biologicals proteins and lysates for ULK2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for ULK2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for ULK2
- antibodies-online Antibodies for ULK2: See all 113
- Search antibodies-online for kits
- antibodies-online Proteins for ULK2: See all 3
- Search antibodies-online for peptides
- GeneTex ULK2 antibody for ULK2
- GeneTex Dpm1 antibody for ULK2
- Search GeneTex for Proteins for ULK2
- ViGene Biosciences adenoviral particle packaged cDNA for ULK2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
- Search ViGene Biosciences for ULK2
- Search ViGene Biosciences for ULK2
- Santa Cruz Biotechnology (SCBT) Antibodies for ULK2
- Search Santa Cruz Biotechnology (SCBT) for ULK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- Custom Antibody ServicesProSci Antibodies for ULK2
Sources for ULK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon