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Aliases for ULK2 Gene

Aliases for ULK2 Gene

  • Unc-51 Like Autophagy Activating Kinase 2 2 3 5
  • EC 2.7.11.1 4 61
  • Serine/Threonine-Protein Kinase ULK2 3
  • Unc-51 (C. Elegans)-Like Kinase 2 2
  • Unc-51-Like Kinase 2 (C. Elegans) 2
  • Unc-51-Like Kinase 2 4
  • EC 2.7.11 61
  • KIAA0623 4
  • Unc51.2 3
  • ATG1B 3

External Ids for ULK2 Gene

Previous GeneCards Identifiers for ULK2 Gene

  • GC17M019848
  • GC17M021314
  • GC17M019578
  • GC17M019836
  • GC17M019839
  • GC17M019614
  • GC17M019674
  • GC17M019053

Summaries for ULK2 Gene

Entrez Gene Summary for ULK2 Gene

  • This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

GeneCards Summary for ULK2 Gene

ULK2 (Unc-51 Like Autophagy Activating Kinase 2) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and mTOR signalling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK1.

UniProtKB/Swiss-Prot for ULK2 Gene

  • Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK2 Gene

Genomics for ULK2 Gene

Regulatory Elements for ULK2 Gene

Enhancers for ULK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G019902 0.5 ENCODE 12.5 -35.7 -35704 1.5 ZFHX2 FOS HNF4A EGR2 AKAP10 ULK2 ENSG00000261033 ENSG00000252349 ENSG00000270091 ENSG00000266126
GH17G019875 0.8 Ensembl ENCODE 6.3 -9.0 -8959 2.2 NRF1 SCRT2 MAX NR3C1 MYC ULK2 ENSG00000264932 GC17M019789 ENSG00000276406
GH17G019904 0.4 Ensembl 12.5 -37.5 -37458 0.8 ZNF10 ENSG00000261033 ULK2 AKAP10 ENSG00000252349 ENSG00000270091 LOC102724624 ENSG00000266126
GH17G020008 1.4 FANTOM5 ENCODE 2.7 -142.3 -142338 3.5 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF2 ZNF207 ZNF143 ZNF263 SP3 AKAP10 ENSG00000261033 MEIS3P2 LGALS9B ULK2 SPECC1 ENSG00000225681
GH17G019288 0.8 ENCODE dbSUPER 4.4 +579.2 579229 1.1 ZFHX2 POLR2A HLF TEAD4 KDM1A ZNF623 EGR2 ENSG00000262319 ULK2 GC17P019288 EPN2-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ULK2 on UCSC Golden Path with GeneCards custom track

Promoters for ULK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092291 536 2001 SIN3A ZNF2 RAD21 GLIS2 GATA2 SP3 CEBPB REST ZEB2 ZFP69B

Genomic Location for ULK2 Gene

Chromosome:
17
Start:
19,770,828 bp from pter
End:
19,867,936 bp from pter
Size:
97,109 bases
Orientation:
Minus strand

Genomic View for ULK2 Gene

Genes around ULK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK2 Gene

Proteins for ULK2 Gene

  • Protein details for ULK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYT8-ULK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK2
    Protein Accession:
    Q8IYT8
    Secondary Accessions:
    • A8MY69
    • O75119

    Protein attributes for ULK2 Gene

    Size:
    1036 amino acids
    Molecular mass:
    112694 Da
    Quaternary structure:
    • Interacts with SYNGAP1 (By similarity). Component of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1/FIP200. Interacts (via C-terminus) with ATG13/KIAA0652. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR.
    SequenceCaution:
    • Sequence=BAA31598.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ULK2 Gene

Selected DME Specific Peptides for ULK2 Gene

Q8IYT8:
  • KEIKILKEL
  • YDAKADLWS
  • MAATLCGSPMYMAPEVIMS
  • KIADFGFAR
  • HRDLKPQN

Post-translational modifications for ULK2 Gene

  • Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ULK2 Gene

Gene Families for ULK2 Gene

Suggested Antigen Peptide Sequences for ULK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYT8

UniProtKB/Swiss-Prot:

ULK2_HUMAN :
  • The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Domain:
  • The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
genes like me logo Genes that share domains with ULK2: view

Function for ULK2 Gene

Molecular function for ULK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

Enzyme Numbers (IUBMB) for ULK2 Gene

Gene Ontology (GO) - Molecular Function for ULK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 18936157
GO:0005515 protein binding IPI 18936157
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with ULK2: view
genes like me logo Genes that share phenotypes with ULK2: view

Animal Models for ULK2 Gene

MGI Knock Outs for ULK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ULK2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ULK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK2 Gene

Localization for ULK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULK2 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ULK2 gene
Compartment Confidence
cytosol 3
nucleus 2
lysosome 2

Gene Ontology (GO) - Cellular Components for ULK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0034045 pre-autophagosomal structure membrane IDA 18936157
genes like me logo Genes that share ontologies with ULK2: view

Pathways & Interactions for ULK2 Gene

genes like me logo Genes that share pathways with ULK2: view

Pathways by source for ULK2 Gene

1 GeneTex pathway for ULK2 Gene
2 R&D Systems pathways for ULK2 Gene

SIGNOR curated interactions for ULK2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ULK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006914 autophagy IDA,IEA 18936157
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development IEA --
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with ULK2: view

Drugs & Compounds for ULK2 Gene

(1) Drugs for ULK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for ULK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ULK2: view

Transcripts for ULK2 Gene

Unigene Clusters for ULK2 Gene

Unc-51-like kinase 2 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ULK2

Alternative Splicing Database (ASD) splice patterns (SP) for ULK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: - - -
SP9: -
SP10:
SP11:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ULK2 Gene

GeneLoc Exon Structure for
ULK2
ECgene alternative splicing isoforms for
ULK2

Expression for ULK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ULK2 Gene

Protein differential expression in normal tissues from HIPED for ULK2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULK2 Gene



Protein tissue co-expression partners for ULK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ULK2 Gene:

ULK2

SOURCE GeneReport for Unigene cluster for ULK2 Gene:

Hs.168762

Evidence on tissue expression from TISSUES for ULK2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ULK2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ULK2 Gene

Orthologs for ULK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ULK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULK2 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ULK2 34 35
  • 92.6 (n)
mouse
(Mus musculus)
Mammalia Ulk2 34 16 35
  • 90.48 (n)
rat
(Rattus norvegicus)
Mammalia Ulk2 34
  • 90.41 (n)
cow
(Bos Taurus)
Mammalia ULK2 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ULK2 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ULK2 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ULK2 34 35
  • 79.34 (n)
lizard
(Anolis carolinensis)
Reptilia ULK2 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk2 34
  • 73.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8048 34
zebrafish
(Danio rerio)
Actinopterygii ulk2 34 35
  • 70.98 (n)
Dr.16298 34
fruit fly
(Drosophila melanogaster)
Insecta Atg1 35
  • 38 (a)
OneToMany
CG8866 36
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-51 36 35
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG1 35 37
  • 25 (a)
OneToMany
Species where no ortholog for ULK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ULK2 Gene

ENSEMBL:
Gene Tree for ULK2 (if available)
TreeFam:
Gene Tree for ULK2 (if available)

Paralogs for ULK2 Gene

Paralogs for ULK2 Gene

genes like me logo Genes that share paralogs with ULK2: view

Variants for ULK2 Gene

Sequence variations from dbSNP and Humsavar for ULK2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_041282 A metastatic melanoma sample
VAR_041283 A metastatic melanoma sample
rs193921089 Uncertain significance 19,845,333(-) TGGCT(G/T)CAACA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000034249 -- 19,856,990(+) AAAAA(A/C)AAAAA intron-variant
rs1000071911 -- 19,818,806(+) TTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ULK2 Gene

Variant ID Type Subtype PubMed ID
esv2649888 CNV deletion 19546169
esv3640183 CNV loss 21293372
nsv1061317 CNV gain 25217958
nsv1063892 CNV gain 25217958
nsv1138505 CNV deletion 24896259
nsv2002 CNV insertion 18451855
nsv510435 OTHER sequence alteration 20534489
nsv960436 CNV duplication 23825009

Variation tolerance for ULK2 Gene

Residual Variation Intolerance Score: 9.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULK2 Gene

Human Gene Mutation Database (HGMD)
ULK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ULK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK2 Gene

Disorders for ULK2 Gene

Relevant External Links for ULK2

Genetic Association Database (GAD)
ULK2
Human Genome Epidemiology (HuGE) Navigator
ULK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULK2

No disorders were found for ULK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK2 Gene

Publications for ULK2 Gene

  1. Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. (PMID: 10557072) Yan J. … Muramatsu M. (Oncogene 1999) 2 3 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PMID: 18936157) Chan E.Y.W. … Tooze S.A. (Mol. Cell. Biol. 2009) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4 64

Products for ULK2 Gene

  • Addgene plasmids for ULK2

Sources for ULK2 Gene

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