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Aliases for ULK2 Gene

Aliases for ULK2 Gene

  • Unc-51 Like Autophagy Activating Kinase 2 2 3 5
  • EC 2.7.11.1 4 63
  • Unc-51 (C. Elegans)-Like Kinase 2 2
  • Unc-51-Like Kinase 2 (C. Elegans) 2
  • Unc-51-Like Kinase 2 4
  • EC 2.7.11 63
  • KIAA0623 4
  • Unc51.2 3
  • ATG1B 3

External Ids for ULK2 Gene

Previous GeneCards Identifiers for ULK2 Gene

  • GC17M019848
  • GC17M021314
  • GC17M019578
  • GC17M019836
  • GC17M019839
  • GC17M019614
  • GC17M019674
  • GC17M019053

Summaries for ULK2 Gene

Entrez Gene Summary for ULK2 Gene

  • This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

GeneCards Summary for ULK2 Gene

ULK2 (Unc-51 Like Autophagy Activating Kinase 2) is a Protein Coding gene. Diseases associated with ULK2 include cecal disease. Among its related pathways are p53 Pathway (RnD) and Longevity regulating pathway - multiple species. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK3.

UniProtKB/Swiss-Prot for ULK2 Gene

  • Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK2 Gene

Genomics for ULK2 Gene

Regulatory Elements for ULK2 Gene

Promoters for ULK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ULK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ULK2 Gene

Chromosome:
17
Start:
19,770,828 bp from pter
End:
19,867,936 bp from pter
Size:
97,109 bases
Orientation:
Minus strand

Genomic View for ULK2 Gene

Genes around ULK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK2 Gene

Proteins for ULK2 Gene

  • Protein details for ULK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYT8-ULK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK2
    Protein Accession:
    Q8IYT8
    Secondary Accessions:
    • A8MY69
    • O75119

    Protein attributes for ULK2 Gene

    Size:
    1036 amino acids
    Molecular mass:
    112694 Da
    Quaternary structure:
    • Interacts with SYNGAP1 (By similarity). Component of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1/FIP200. Interacts (via C-terminus) with ATG13/KIAA0652. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR.
    SequenceCaution:
    • Sequence=BAA31598.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ULK2 Gene

Proteomics data for ULK2 Gene at MOPED

Selected DME Specific Peptides for ULK2 Gene

Post-translational modifications for ULK2 Gene

  • Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ULK2 Gene

Antibody Products

Domains & Families for ULK2 Gene

Gene Families for ULK2 Gene

Suggested Antigen Peptide Sequences for ULK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYT8

UniProtKB/Swiss-Prot:

ULK2_HUMAN :
  • The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Domain:
  • The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
genes like me logo Genes that share domains with ULK2: view

Function for ULK2 Gene

Molecular function for ULK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

Enzyme Numbers (IUBMB) for ULK2 Gene

genes like me logo Genes that share phenotypes with ULK2: view

Animal Models for ULK2 Gene

MGI Knock Outs for ULK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ULK2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK2 Gene

Localization for ULK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULK2 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULK2 Gene COMPARTMENTS Subcellular localization image for ULK2 gene
Compartment Confidence
cytosol 3
nucleus 2
vacuole 2
lysosome 1

No data available for Gene Ontology (GO) - Cellular Components for ULK2 Gene

Pathways & Interactions for ULK2 Gene

genes like me logo Genes that share pathways with ULK2: view

Pathways by source for ULK2 Gene

1 GeneTex pathway for ULK2 Gene
1 BioSystems pathway for ULK2 Gene
2 R&D Systems pathways for ULK2 Gene

SIGNOR curated interactions for ULK2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ULK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007409 axonogenesis IEA --
GO:0046777 protein autophosphorylation IDA 18936157
GO:0048675 axon extension IEA,IBA --
genes like me logo Genes that share ontologies with ULK2: view

Drugs & Compounds for ULK2 Gene

(1) Drugs for ULK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for ULK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ULK2: view

Transcripts for ULK2 Gene

Unigene Clusters for ULK2 Gene

Unc-51-like kinase 2 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: - - -
SP9: -
SP10:
SP11:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ULK2 Gene

GeneLoc Exon Structure for
ULK2
ECgene alternative splicing isoforms for
ULK2

Expression for ULK2 Gene

mRNA expression in normal human tissues for ULK2 Gene

Protein differential expression in normal tissues from HIPED for ULK2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULK2 Gene



SOURCE GeneReport for Unigene cluster for ULK2 Gene Hs.168762

genes like me logo Genes that share expression patterns with ULK2: view

Protein tissue co-expression partners for ULK2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ULK2 Gene

Orthologs for ULK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ULK2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ULK2 35
  • 92.6 (n)
  • 94.88 (a)
ULK2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ulk2 35
  • 90.48 (n)
  • 93.73 (a)
Ulk2 16
Ulk2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ULK2 35
  • 99.55 (n)
  • 99.32 (a)
ULK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ulk2 35
  • 90.41 (n)
  • 93.92 (a)
cow
(Bos Taurus)
Mammalia ULK2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ULK2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ULK2 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ULK2 35
  • 79.34 (n)
  • 86.68 (a)
ULK2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ULK2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk2 35
  • 73.64 (n)
  • 80.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8048 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16298 35
ulk2 35
  • 70.98 (n)
  • 76.18 (a)
ulk2 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8866 37
  • 37 (a)
Atg1 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-51 37
  • 46 (a)
unc-51 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG1 36
  • 25 (a)
OneToMany
ATG1 38
Species with no ortholog for ULK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ULK2 Gene

ENSEMBL:
Gene Tree for ULK2 (if available)
TreeFam:
Gene Tree for ULK2 (if available)

Paralogs for ULK2 Gene

Paralogs for ULK2 Gene

genes like me logo Genes that share paralogs with ULK2: view

Variants for ULK2 Gene

Sequence variations from dbSNP and Humsavar for ULK2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34670978 - 19,838,564(+) ATAAG(A/G)TGATG nc-transcript-variant, reference, missense
VAR_041282 A metastatic melanoma sample
VAR_041283 A metastatic melanoma sample
rs55730189 - 19,783,903(+) GGGCC(C/T)CACTA nc-transcript-variant, reference, missense
rs35107651 - 19,782,002(+) GTCAG(G/T)TCCAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ULK2 Gene

Variant ID Type Subtype PubMed ID
dgv3101n71 CNV Loss 21882294
nsv510435 CNV Loss 20534489
nsv2002 CNV Insertion 18451855
esv2649888 CNV Deletion 19546169
nsv907868 CNV Gain 21882294

Variation tolerance for ULK2 Gene

Residual Variation Intolerance Score: 9.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULK2 Gene

HapMap Linkage Disequilibrium report
ULK2
Human Gene Mutation Database (HGMD)
ULK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK2 Gene

Disorders for ULK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ULK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cecal disease
  • disorder of cecum
- elite association - COSMIC cancer census association via MalaCards
Search ULK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ULK2

Genetic Association Database (GAD)
ULK2
Human Genome Epidemiology (HuGE) Navigator
ULK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULK2
genes like me logo Genes that share disorders with ULK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ULK2 Gene

Publications for ULK2 Gene

  1. Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. (PMID: 10557072) Yan J. … Muramatsu M. (Oncogene 1999) 2 3 23 67
  2. Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth. (PMID: 24923441) Shukla S. … Somasundaram K. (J. Biol. Chem. 2014) 3
  3. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PMID: 23043107) Alemu E.A. … Johansen T. (J. Biol. Chem. 2012) 3
  4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3
  5. Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death. (PMID: 21475306) Gao W. … Wang X. (Cell Death Differ. 2011) 3

Products for ULK2 Gene

Sources for ULK2 Gene

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