Aliases for ULK2 Gene
Aliases for ULK2 Gene
External Ids for ULK2 Gene
- HGNC: 13480
- Entrez Gene: 9706
- Ensembl: ENSG00000083290
- OMIM: 608650
- UniProtKB: Q8IYT8
Previous GeneCards Identifiers for ULK2 Gene
- GC17M019848
- GC17M021314
- GC17M019578
- GC17M019836
- GC17M019839
- GC17M019614
- GC17M019674
- GC17M019053
Summaries for ULK2 Gene
-
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
GeneCards Summary for ULK2 Gene
ULK2 (Unc-51 Like Autophagy Activating Kinase 2) is a Protein Coding gene. Among its related pathways are mTOR signalling and Autophagy - animal. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK1.
UniProtKB/Swiss-Prot for ULK2 Gene
-
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Additional gene information for ULK2 Gene
- Monarch Initiative
- Search for ULK2 at DataMed
- Search for ULK2 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK2 Gene
Genomics for ULK2 Gene
GeneHancer (GH) Regulatory Elements for ULK2 Gene
Promoters and enhancers for ULK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ULK2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ULK2 gene promoter:
Regulatory Element Products
Genomic Locations for ULK2 Gene
Genomic Locations for ULK2 Gene
- chr17:19,770,828-19,867,936
- (GRCh38/hg38)
- Size:
- 97,109 bases
- Orientation:
- Minus strand
- chr17:19,674,142-19,771,249
- (GRCh37/hg19)
Genomic View for ULK2 Gene
Genes around ULK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by Ensembl
- 17p11.2 by Entrez Gene
- 17p11.2 by HGNC
ULK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ULK2 Gene
Proteins for ULK2 Gene
-
Protein details for ULK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYT8-ULK2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase ULK2
- Protein Accession:
- Q8IYT8
- A8MY69
- O75119
Protein attributes for ULK2 Gene
- Size:
- 1036 amino acids
- Molecular mass:
- 112694 Da
- Quaternary structure:
-
- Interacts with SYNGAP1 (By similarity). Component of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1/FIP200. Interacts (via C-terminus) with ATG13/KIAA0652. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR.
- SequenceCaution:
-
- Sequence=BAA31598.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for ULK2 Gene
Selected DME Specific Peptides for ULK2 Gene
- Q8IYT8:
-
- KEIKILKEL
- YDAKADLWS
- MAATLCGSPMYMAPEVIMS
- KIADFGFAR
- HRDLKPQN
Post-translational modifications for ULK2 Gene
- Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.
Other Protein References for ULK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ULK2
-
Abcam antibodies for ULK2
- Invitrogen Antibodies for ULK2
- GeneTex ULK2 antibody for ULK2
-
Custom Antibody ServicesProSci Antibodies for ULK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ULK2
Protein Products
-
OriGene Purified Proteins for ULK2
- Search Origene for MassSpec and Protein Over-expression Lysates for ULK2
- Origene Custom Protein Services for ULK2
- Search GeneTex for Proteins for ULK2
-
Abcam proteins for ULK2
Assay Products
- antibodies-online: Search results for available ULK2 related products ranked by validation data
Domains & Families for ULK2 Gene
Gene Families for ULK2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ULK2 Gene
Suggested Antigen Peptide Sequences for ULK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IYT8UniProtKB/Swiss-Prot:
ULK2_HUMAN :- The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
- Domain:
-
- The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Function for ULK2 Gene
Molecular function for ULK2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Enzyme Numbers (IUBMB) for ULK2 Gene
Phenotypes From GWAS Catalog for ULK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IDA | 18936157 |
| GO:0005515 | protein binding | IPI | 18936157 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for ULK2 Gene
- MGI mutant phenotypes for ULK2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ULK2:
-
- Increased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Increased G1 DNA content
- G0/1 arrest
- Transferrin accumulation in the perinuclear area
- Increased shRNA abundance (Z-score > 2)
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability of wild-type and TP53 knockout cells
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased viability
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ULK2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
- Search ViGene Biosciences for ULK2
CRISPR Products
-
OriGene CRISPR knockouts for ULK2
- genomics-online: gRNA clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
- Applied Biological Materials CRISPR for ULK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- GenScript: Design CRISPR guide RNA sequences for ULK2
miRNA for ULK2 Gene
- miRTarBase miRNAs that target ULK2
-
- hsa-mir-335-5p (MIRT016824)
- hsa-mir-2681-5p (MIRT076301)
- hsa-mir-6807-5p (MIRT495001)
- hsa-mir-4713-5p (MIRT641816)
- hsa-mir-2116-3p (MIRT641817)
- hsa-mir-532-3p (MIRT641818)
- hsa-mir-150-5p (MIRT641819)
- hsa-mir-6814-5p (MIRT641820)
- hsa-mir-3691-3p (MIRT641821)
- hsa-mir-1264 (MIRT641822)
- hsa-mir-302c-5p (MIRT651871)
- hsa-mir-3143 (MIRT651872)
- hsa-mir-6514-3p (MIRT674455)
- hsa-mir-24-3p (MIRT674456)
- hsa-mir-4284 (MIRT674457)
- hsa-mir-4743-5p (MIRT674458)
- hsa-mir-564 (MIRT674459)
- hsa-mir-1290 (MIRT674460)
- hsa-mir-6847-3p (MIRT674461)
- hsa-mir-6811-3p (MIRT674462)
- hsa-mir-214-5p (MIRT674463)
- hsa-mir-383-3p (MIRT674464)
- hsa-mir-3614-5p (MIRT674465)
- hsa-mir-541-5p (MIRT674466)
- hsa-mir-6842-5p (MIRT709348)
- hsa-mir-6848-3p (MIRT709349)
- hsa-mir-6843-3p (MIRT709350)
- hsa-mir-3127-5p (MIRT709351)
- hsa-mir-593-3p (MIRT709352)
- hsa-mir-323a-5p (MIRT709353)
- hsa-mir-4483 (MIRT709354)
- hsa-mir-1293 (MIRT709355)
- hsa-mir-4766-5p (MIRT709356)
- hsa-mir-4653-5p (MIRT709357)
- hsa-mir-3921 (MIRT709358)
- hsa-mir-301b-5p (MIRT709359)
- hsa-mir-301a-5p (MIRT709360)
- hsa-mir-146a-3p (MIRT709361)
- hsa-mir-6823-5p (MIRT709362)
- hsa-mir-33b-5p (MIRT725090)
- hsa-mir-26b-5p (MIRT731401)
- hsa-mir-1273h-5p (MIRT736906)
- hsa-mir-1827 (MIRT738168)
- hsa-mir-1910-3p (MIRT738455)
- hsa-mir-2467-3p (MIRT739320)
- hsa-mir-30b-3p (MIRT739796)
- hsa-mir-3192-5p (MIRT741040)
- hsa-mir-3612 (MIRT741621)
- hsa-mir-3689a-3p (MIRT742298)
- hsa-mir-3689b-3p (MIRT742368)
- hsa-mir-3689c (MIRT742438)
- hsa-mir-377-5p (MIRT742731)
- hsa-mir-4257 (MIRT743444)
- hsa-mir-455-3p (MIRT746234)
- hsa-mir-490-3p (MIRT749181)
- hsa-mir-6086 (MIRT751884)
- hsa-mir-6499-3p (MIRT752851)
- hsa-mir-650 (MIRT753069)
- hsa-mir-6511a-5p (MIRT753180)
- hsa-mir-6516-5p (MIRT753389)
- hsa-mir-6779-5p (MIRT755542)
- hsa-mir-6780a-5p (MIRT755613)
- hsa-mir-7851-3p (MIRT759900)
- hsa-mir-149-3p (MIRT762841)
- hsa-mir-34b-3p (MIRT765808)
- hsa-mir-4728-5p (MIRT771757)
- hsa-mir-6500-3p (MIRT776479)
- hsa-mir-6785-5p (MIRT779167)
- hsa-mir-6799-5p (MIRT779468)
- hsa-mir-6883-5p (MIRT780963)
- hsa-mir-7106-5p (MIRT781398)
miRNA Products
- Search ViGene Biosciences for ULK2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
- genomics-online: shRNA clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ULK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ULK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ULK2
- Applied Biological Materials Clones for ULK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ULK2
-
ViGene Biosciences adenoviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK2 Gene
Localization for ULK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ULK2 Gene
- Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane.
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | -- |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
| GO:0034045 | phagophore assembly site membrane | IDA,IEA | 18936157 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ULK2 Gene
Pathways & Interactions for ULK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Autophagy Pathway | ||
| 2 | Autophagy - animal | ||
| 3 | mTOR signaling pathway (KEGG) | ||
| 4 | mTOR signalling | ||
Pathways by source for ULK2 Gene
1 GeneTex pathway for ULK2 Gene
2 BioSystems pathways for ULK2 Gene
3 KEGG pathways for ULK2 Gene
1 R&D Systems pathway for ULK2 Gene
Interacting Proteins for ULK2 Gene
SIGNOR curated interactions for ULK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006914 | autophagy | IDA | 18936157 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007409 | axonogenesis | IEA | -- |
Drugs & Compounds for ULK2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for ULK2 Gene
mRNA/cDNA for ULK2 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (176) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ULK2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ULK2
- genomics-online: gRNA clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
- Applied Biological Materials CRISPR for ULK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- GenScript: Design CRISPR guide RNA sequences for ULK2
miRNA Products
- Search ViGene Biosciences for ULK2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
- genomics-online: shRNA clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ULK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ULK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ULK2
- Applied Biological Materials Clones for ULK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | · | 16c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: |
Expression for ULK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
This gene is overexpressed in Peripheral blood mononuclear cells (68.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULK2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ULK2 Gene:
ULK2SOURCE GeneReport for Unigene cluster for ULK2 Gene:
Hs.168762Evidence on tissue expression from TISSUES for ULK2 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs and template standards for ULK2
-
OriGene qPCR primer pairs for ULK2
- genomics-online: primer clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ULK2 Gene
Orthologs for ULK2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ULK2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ULK2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ulk2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ulk2 33 |
|
||
| cow (Bos Taurus) |
Mammalia | ULK2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ULK2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ULK2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ULK2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ULK2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ulk2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8048 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ulk2 33 34 |
|
||
| Dr.16298 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Atg1 34 |
|
OneToMany | |
| CG8866 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | unc-51 35 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATG1 34 36 |
|
OneToMany |
- Species where no ortholog for ULK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ULK2 Gene
(31) SIMAP similar genes for ULK2 Gene using alignment to 4 proteins:
Variants for ULK2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1060499754 | likely-pathogenic, Abnormality of brain morphology | 19,797,472(-) | T/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs193921089 | uncertain-significance, Malignant tumor of prostate | 19,845,333(-) | C/A | 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| VAR_041282 | A metastatic melanoma sample | p.Gly627Glu | |||
| VAR_041283 | A metastatic melanoma sample | p.Ala662Val | |||
| rs1000034249 | -- | 19,856,990(-) | A/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2649888 | CNV | deletion | 19546169 |
| esv3640183 | CNV | loss | 21293372 |
| nsv1061317 | CNV | gain | 25217958 |
| nsv1063892 | CNV | gain | 25217958 |
| nsv1138505 | CNV | deletion | 24896259 |
| nsv2002 | CNV | insertion | 18451855 |
| nsv510435 | OTHER | sequence alteration | 20534489 |
| nsv960436 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
9.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.52;
55.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ULK2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK2 Gene
Disorders for ULK2 Gene
Additional Disease Information for ULK2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ULK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK2 Gene
Publications for ULK2 Gene
- Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. (PMID: 10557072) Yan J … Muramatsu M (Oncogene 1999) 2 3 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PMID: 18936157) Chan EY … Tooze SA (Molecular and cellular biology 2009) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
Products for ULK2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ULK2
- Search Origene for MassSpec and Protein Over-expression Lysates for ULK2
- Origene Custom Protein Services for ULK2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
- OriGene qPCR primer pairs and template standards for ULK2
- OriGene qPCR primer pairs for ULK2
- OriGene CRISPR knockouts for ULK2
- OriGene ORF clones in human for ULK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ULK2
- GenScript: Next-day shipping of latest version cDNA ORF clones for ULK2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ULK2
- GenScript Custom Assay Services for ULK2
- GenScript Custom overexpressing Cell Line Services for ULK2
- GenScript: Design CRISPR guide RNA sequences for ULK2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ULK2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ULK2
- Novus Biologicals lysates and proteins for ULK2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ULK2
- Abcam proteins for ULK2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for ULK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for ULK2
- VectorBuilder custom plasmid, inducible vectors for ULK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ULK2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ULK2
- antibodies-online: Search results for 144 available ULK2 Antibodies ranked by validation data
- Compare Top ULK2 Antibodies
- antibodies-online: Search results for available ULK2 related products ranked by validation data
- antibodies-online: Search results for 5 available ULK2 Proteins ranked by validation data
- Compare Top ULK2 Proteins
- GeneTex ULK2 antibody for ULK2
- Search GeneTex for Proteins for ULK2
- ViGene Biosciences adenoviral particle packaged cDNA for ULK2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
- Search ViGene Biosciences for ULK2
- Santa Cruz Biotechnology (SCBT) Antibodies for ULK2
- Search Santa Cruz Biotechnology (SCBT) for ULK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- Custom Antibody ServicesProSci Antibodies for ULK2
- Search for ULK2 Proteins at ProSci
- Horizon Cell Lines for ULK2
- genomics-online: cdna clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
- orf clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
- genomics-online: gRNA clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
- genomics-online: primer clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
- genomics-online: shRNA clones - Search results for 65 available ULK2 gene related products
- Overview of 65 available ULK2 gene related products
Sources for ULK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew