ULK2 Gene
protein-coding GIFtS: 60
GCID: GC17M019674
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|
unc-51-like kinase 2 (C. elegans)(Previous name: unc-51 (C. elegans)-like kinase 2 )
| |
Aliases
for ULK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Unc-51-Like Kinase 2 (C. Elegans)1 2 | | Unc-51 (C. Elegans)-Like Kinase 21 | | ATG1B1 2 | | Serine/Threonine-Protein Kinase ULK22 | | Unc51.21 2 | | Unc-51-Like Kinase 23 | | KIAA06231 3 | | EC 2.7.118 | | EC 2.7.11.13 8 | | |
Export aliases for ULK2 gene to outside databasesPrevious GC identifers: GC17M019848 GC17M021314 GC17M019578 GC17M019836 GC17M019839 GC17M019614 GC17M019053 |
Summaries
for ULK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ULK2:
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonalelongation. The structure of this protein is similar to the C. elegans protein in that both proteins have anN-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is locatedwithin the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the sameprotein have been identified. (provided by RefSeq, Dec 2008)
UniProtKB/Swiss-Prot: ULK2_HUMAN, Q8IYT8Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream ofphosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes.Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator ofmammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK,also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. Mayphosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved inammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassiumconcentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: maygovern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathwayswithin developing axons
|
Genomic Views
for ULK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ULK2 gene promoter:
ER-alpha Elk-1 AP-2alpha isoform 2 NF-AT NF-AT4 NF-AT2 NF-AT3 AP-2alpha isoform 4 AP-2alpha NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ULK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2ULK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M019674: view genomic region
(about GC identifiers)
Start:
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19,674,142 bp from pter |
End:
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19,771,249 bp from pter |
Size:
|
97,108 bases |
Orientation:
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minus strand |
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Proteins
for ULK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ULK2_HUMAN, Q8IYT8 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase ULK2 Size: 1036 amino acids; 112694 Da
Subunit: Interacts with SYNGAP1 (By similarity). Component of a complex consisting of ATG13/KIAA0652, ULK1 andRB1CC1/FIP200. Interacts (via C-terminus) with ATG13/KIAA0652. Associates with the mammalian target of rapamycincomplex 1 (mTORC1) through an interaction with RPTOR
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomalmembrane
Sequence caution: Sequence=BAA31598.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8MY69 O75119Explore the universe of human proteins at neXtProt for ULK2: NX_Q8IYT8
Post-translational modifications:
Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading toactivate autophagy1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYT8
4/5 DME Specific Peptides for ULK2 (Q8IYT8) (see all 5)
ULK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001136082.1 NP_055498.3
ENSEMBL proteins: ENSP00000354877 ENSP00000378914 ENSP00000464892 ENSP00000465666 ENSP00000467277
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030659 | cytoplasmic vesicle membrane |
IEA | -- | | GO:0034045 | pre-autophagosomal structure membrane |
IDA | 18936157 |
ULK2 for ontologies About GeneDecksing
ULK2 Antibody Products:
Assay Products for ULK2: |
Protein
Domains /
Families
for ULK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ULK2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8IYT8ProtoNet protein and cluster: Q8IYT8 UniProtKB/Swiss-Prot: ULK2_HUMAN, Q8IYT8Domain: The CTD-like region mediates membrane-binding and incorporation into large protein complexesSimilarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamilySimilarity: Contains 1 protein kinase domain |
Function
for ULK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ULK2_HUMAN, Q8IYT8Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream ofphosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes.Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator ofmammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK,also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. Mayphosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved inammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassiumconcentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: maygovern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathwayswithin developing axonsCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULK2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ULK2 (NM_014683) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ULK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ULK2 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for ULK2:
Animal Models:
Mouse knock-outs for ULK2: Ulk2tm1Lex Ulk2tm1.1Thsn
4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Ulk2):
ULK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ULK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mTOR signalling | | | 2 | Regulation of IFNA signaling | | | 3 | Development_CNTF receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for ULK2
2 
Kegg Pathways (Kegg details for ULK2):
ULK2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ULK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/345 Interacting proteins for ULK2 (Q8IYT82, 3 ENSP000003548774) via UniProtKB, MINT, STRING, and/or I2D (see all 345)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
ULK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ULK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ULK2
2 HMDB Compounds for ULK2 About this table
Search CenterWatch for drugs/clinical trials and news about ULK2
|
Transcripts
for ULK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ULK2 gene (2 alternative transcripts): NM_001142610.1 NM_014683.3 Unigene Cluster for ULK2: Unc-51-like kinase 2 (C. elegans) Hs.168762 [show with all ESTs]Unigene Representative Sequence: NM_01468311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000570983 ENST00000361658(uc002gwm.4) ENST00000395544(uc002gwn.3)
ENST00000571454 ENST00000575432 ENST00000571137 ENST00000580130 ENST00000574854
ENST00000571177 ENST00000574732 ENST00000580118
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULK2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ULK2 (NM_014683) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ULK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK2 |
Additional cDNA sequence: AB014523.1 AK098316.1 AK314345.1 AL080134.1 BC034988.1 BC039310.1 12 DOTS entries: DT.442064 DT.95254360 DT.95300638 DT.100820269 DT.409255 DT.95162245 DT.100820265 DT.100820264 DT.100820267 DT.121009378 DT.92009029 DT.102825975 24/176 AceView cDNA sequences (see all 176): BM717560 W01096 BX440574 CB851547 D57833 AA743663 T16293 CR613562 F05878 CR591285 BM556218 AA331534 AL044752 AL045472 CD251854 AA765145 AA418868 CB321831 AA504115 Z45674 AA858045 AI225120 N42968 Z41343
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ULK2 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | · | 16c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
| ExUns: | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for ULK2
|
Expression
for ULK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ULK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ULK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ULK2
SOURCE GeneReport for Unigene cluster: Hs.168762
SABiosciences Expression via Pathway-Focused PCR Arrays including ULK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ULK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ULK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK2 |
Orthologs
for ULK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ULK2 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ULK21 |
unc-51-like kinase 2 (C. elegans) |
79.25(n)
86.68(a) |
|
417614 XM_415858.3 XP_415858.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ULK26 |
-- |
65(a) |
1 ↔ 1 |
GL344046.1(30105-80177) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.80482 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.83(n) |
|
BG731037.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.162982 |
Transcribed sequence with weak similarity to protein more |
76.96(n) |
|
CK238267.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG88663
Atg11 |
protein amino acid phosphorylation protein
kinase3
Autophagy-specific gene 11 |
37(a)3
50.05(n)1
45.21(a)1 |
|
85D113
394541 NM_140344.21 NP_648601.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-511 , 3 |
serine/threonine protein kinase3
Protein UNC-511 |
46(a)3
49.27(n)1
44.51(a)1 |
|
V(19988350-19996523)3
1803111 NM_075468.31 NP_507869.11 |
ENSEMBL Gene Tree for ULK2 (if available)
TreeFam Gene Tree for ULK2 (if available) |
Paralogs
for ULK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ULK2 gene
- PDIK1L2 STK362 ULK12 STK332 ULK32 STK352
18/31 SIMAP similar genes for ULK2 using alignment to 4 protein entries: ULK2_HUMAN (see all proteins)
(see all similar genes):MARK4 CAMK1G ULK3 DKFZp564L2416 KIAA0999 NEK6
PRKAA1 NUAK1 NF2 ULK1 PRKACB KIN27
PRKD2 RPS6KA2 SGK2 PNCK RPS6KA3 STK17A
ULK2 for paralogs About GeneDecksing
|
Genomic Variants
for ULK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ULK2 (19674142 - 19771249 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ULK2
1 CNV: 102422 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ULK2 |
|
Disorders
/ Diseases
for ULK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ULK2 for disorders About GeneDecksing
OMIM gene information: 608650
OMIM disorders: --
4  diseases for ULK2: About MalaCardssmith-magenis syndrome pharyngitis neuronitis alcoholism
Human Genome Epidemiology (HuGE) Navigator: ULK2 (2 documents)
Export disorders for ULK2 gene to outside databases
|
Publications
for ULK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ULK2 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ULK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. (PubMed id 10557072)1, 3, 9 Yan J....Muramatsu M. (1999)
- Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PubMed id 18936157)1, 2 Chan E.Y....Tooze S.A. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PubMed id 23043107)1 Alemu E.A....Johansen T. (2012)
- ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. (PubMed id 21795849)2 Jung C.H.... Kim D.H. (2011)
- The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. (PubMed id 21460635)2 Lee E.J. and Tournier C. (2011)
- Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. (PubMed id 21690395)2 Cheong H.... Thompson C.B. (2011)
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PubMed id 21460634)2 Loffler A.S.... Stork B. (2011)
|
External Searches for ULK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ULK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ULK2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ULK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for ULK2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ULK2 gene:
Search GeneIP for patents involving ULK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ULK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for ULK2 | | OriGene shRNA RFP for ULK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ULK2 | | | OriGene Protein Over-expression Lysate for ULK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ULK2 | | OriGene 3'-UTR Clone for ULK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ULK2 | | OriGene Custom Protein Services for ULK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ULK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ULK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULK2 |
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| | | | Search Tocris compounds for ULK2 |
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 | | | ULK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK2 |
|  |  |  | | | | ThermoFisher Antibody for ULK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK2 |
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