Aliases for ULK2 Gene
Aliases for ULK2 Gene
External Ids for ULK2 Gene
- HGNC: 13480
- Entrez Gene: 9706
- Ensembl: ENSG00000083290
- OMIM: 608650
- UniProtKB: Q8IYT8
Previous GeneCards Identifiers for ULK2 Gene
- GC17M019848
- GC17M021314
- GC17M019578
- GC17M019836
- GC17M019839
- GC17M019614
- GC17M019674
- GC17M019053
Summaries for ULK2 Gene
-
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
GeneCards Summary for ULK2 Gene
ULK2 (Unc-51 Like Autophagy Activating Kinase 2) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and mTOR signalling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK1.
UniProtKB/Swiss-Prot for ULK2 Gene
-
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK2 Gene
Genomics for ULK2 Gene
Regulatory Elements for ULK2 Gene
Enhancers for ULK2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G019902 | 0.5 | ENCODE | 12.5 | -35.7 | -35704 | 1.5 | ZFHX2 FOS HNF4A EGR2 | AKAP10 ULK2 ENSG00000261033 ENSG00000252349 ENSG00000270091 ENSG00000266126 |
| GH17G019875 | 0.8 | Ensembl ENCODE | 6.3 | -9.0 | -8959 | 2.2 | NRF1 SCRT2 MAX NR3C1 MYC | ULK2 ENSG00000264932 GC17M019789 ENSG00000276406 |
| GH17G019904 | 0.4 | Ensembl | 12.5 | -37.5 | -37458 | 0.8 | ZNF10 | ENSG00000261033 ULK2 AKAP10 ENSG00000252349 ENSG00000270091 LOC102724624 ENSG00000266126 |
| GH17G020008 | 1.4 | FANTOM5 ENCODE | 2.7 | -142.3 | -142338 | 3.5 | HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF2 ZNF207 ZNF143 ZNF263 SP3 | AKAP10 ENSG00000261033 MEIS3P2 LGALS9B ULK2 SPECC1 ENSG00000225681 |
| GH17G019288 | 0.8 | ENCODE dbSUPER | 4.4 | +579.2 | 579229 | 1.1 | ZFHX2 POLR2A HLF TEAD4 KDM1A ZNF623 EGR2 | ENSG00000262319 ULK2 GC17P019288 EPN2-IT1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ULK2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ULK2 gene promoter:
Regulatory Element Products
Genomic Location for ULK2 Gene
- Chromosome:
- 17
- Start:
- 19,770,828 bp from pter
- End:
- 19,867,936 bp from pter
- Size:
- 97,109 bases
- Orientation:
- Minus strand
Genomic View for ULK2 Gene
Genes around ULK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by Ensembl
- 17p11.2 by Entrez Gene
- 17p11.2 by HGNC
ULK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ULK2 Gene
Proteins for ULK2 Gene
-
Protein details for ULK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYT8-ULK2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase ULK2
- Protein Accession:
- Q8IYT8
- A8MY69
- O75119
Protein attributes for ULK2 Gene
- Size:
- 1036 amino acids
- Molecular mass:
- 112694 Da
- Quaternary structure:
-
- Interacts with SYNGAP1 (By similarity). Component of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1/FIP200. Interacts (via C-terminus) with ATG13/KIAA0652. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR.
- SequenceCaution:
-
- Sequence=BAA31598.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for ULK2 Gene
Selected DME Specific Peptides for ULK2 Gene
- Q8IYT8:
-
- KEIKILKEL
- YDAKADLWS
- MAATLCGSPMYMAPEVIMS
- KIADFGFAR
- HRDLKPQN
Post-translational modifications for ULK2 Gene
- Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ULK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ULK2
- Invitrogen Antibodies for ULK2
- antibodies-online Antibodies for ULK2: See all 113
- GeneTex ULK2 antibody for ULK2
- GeneTex Dpm1 antibody for ULK2
-
Custom Antibody ServicesProSci Antibodies for ULK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ULK2
Protein Products
-
OriGene Purified Proteins for ULK2
- Search Origene for MassSpec and Protein Over-expression Lysates for ULK2
- Origene Custom Protein Services for ULK2
- antibodies-online Proteins for ULK2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ULK2
Domains & Families for ULK2 Gene
Gene Families for ULK2 Gene
- HGNC:
- IUPHAR :
Protein Domains for ULK2 Gene
Suggested Antigen Peptide Sequences for ULK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IYT8UniProtKB/Swiss-Prot:
ULK2_HUMAN :- The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
- Domain:
-
- The CTD-like region mediates membrane-binding and incorporation into large protein complexes.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Function for ULK2 Gene
Molecular function for ULK2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Enzyme Numbers (IUBMB) for ULK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IDA | 18936157 |
| GO:0005515 | protein binding | IPI | 18936157 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for ULK2 Gene
- MGI mutant phenotypes for ULK2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ULK2:
-
- Increased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Increased G1 DNA content
- G0/1 arrest
- Transferrin accumulation in the perinuclear area
- Increased shRNA abundance (Z-score > 2)
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability of wild-type and TP53 knockout cells
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased viability
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
Animal Model Products
-
Taconic Biosciences Mouse Models for ULK2
- Cyagen custom Knockout/knockin (KOKI) mouse models for ULK2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
- Search ViGene Biosciences for ULK2
CRISPR Products
-
OriGene CRISPR knockouts for ULK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- GenScript: Design CRISPR guide RNA sequences for ULK2
miRNA for ULK2 Gene
- miRTarBase miRNAs that target ULK2
-
- hsa-mir-335-5p (MIRT016824)
- hsa-mir-2681-5p (MIRT076301)
- hsa-mir-6807-5p (MIRT495001)
- hsa-mir-4713-5p (MIRT641816)
- hsa-mir-2116-3p (MIRT641817)
- hsa-mir-532-3p (MIRT641818)
- hsa-mir-150-5p (MIRT641819)
- hsa-mir-6814-5p (MIRT641820)
- hsa-mir-3691-3p (MIRT641821)
- hsa-mir-1264 (MIRT641822)
- hsa-mir-302c-5p (MIRT651871)
- hsa-mir-3143 (MIRT651872)
- hsa-mir-6514-3p (MIRT674455)
- hsa-mir-24-3p (MIRT674456)
- hsa-mir-4284 (MIRT674457)
- hsa-mir-4743-5p (MIRT674458)
- hsa-mir-564 (MIRT674459)
- hsa-mir-1290 (MIRT674460)
- hsa-mir-6847-3p (MIRT674461)
- hsa-mir-6811-3p (MIRT674462)
- hsa-mir-214-5p (MIRT674463)
- hsa-mir-383-3p (MIRT674464)
- hsa-mir-3614-5p (MIRT674465)
- hsa-mir-541-5p (MIRT674466)
- hsa-mir-6842-5p (MIRT709348)
- hsa-mir-6848-3p (MIRT709349)
- hsa-mir-6843-3p (MIRT709350)
- hsa-mir-3127-5p (MIRT709351)
- hsa-mir-593-3p (MIRT709352)
- hsa-mir-323a-5p (MIRT709353)
- hsa-mir-4483 (MIRT709354)
- hsa-mir-1293 (MIRT709355)
- hsa-mir-4766-5p (MIRT709356)
- hsa-mir-4653-5p (MIRT709357)
- hsa-mir-3921 (MIRT709358)
- hsa-mir-301b-5p (MIRT709359)
- hsa-mir-301a-5p (MIRT709360)
- hsa-mir-146a-3p (MIRT709361)
- hsa-mir-6823-5p (MIRT709362)
- hsa-mir-33b-5p (MIRT725090)
miRNA Products
- Search ViGene Biosciences for ULK2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ULK2
- VectorBuilder custom plasmid, inducible vectors for ULK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ULK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ULK2
-
ViGene Biosciences adenoviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ULK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK2 Gene
Localization for ULK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ULK2 Gene
- Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane.
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| lysosome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | -- |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
| GO:0034045 | pre-autophagosomal structure membrane | IDA | 18936157 |
Pathways & Interactions for ULK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Autophagy Pathway | ||
| 2 | Autophagy - animal | ||
| 3 | mTOR signaling pathway (KEGG) | ||
| 4 | p53 Pathway (RnD) | ||
| 5 | mTOR signalling | ||
Pathways by source for ULK2 Gene
1 GeneTex pathway for ULK2 Gene
2 BioSystems pathways for ULK2 Gene
3 KEGG pathways for ULK2 Gene
2 R&D Systems pathways for ULK2 Gene
Interacting Proteins for ULK2 Gene
SIGNOR curated interactions for ULK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006914 | autophagy | IDA,IEA | 18936157 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007409 | axonogenesis | IEA | -- |
Drugs & Compounds for ULK2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for ULK2 Gene
mRNA/cDNA for ULK2 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (176) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ULK2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ULK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- GenScript: Design CRISPR guide RNA sequences for ULK2
miRNA Products
- Search ViGene Biosciences for ULK2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
-
ViGene Biosciences ready-to-package AAV shRNAs for ULK2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ULK2
- VectorBuilder custom plasmid, inducible vectors for ULK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ULK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | · | 16c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
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| SP11: |
Expression for ULK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
This gene is overexpressed in Peripheral blood mononuclear cells (68.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULK2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ULK2 Gene:
ULK2SOURCE GeneReport for Unigene cluster for ULK2 Gene:
Hs.168762Evidence on tissue expression from TISSUES for ULK2 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs and template standards for ULK2
-
OriGene qPCR primer pairs for ULK2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ULK2 Gene
Orthologs for ULK2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ULK2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ULK2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ulk2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ulk2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ULK2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ULK2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ULK2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ULK2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ULK2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ulk2 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8048 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ulk2 34 35 |
|
||
| Dr.16298 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Atg1 35 |
|
OneToMany | |
| CG8866 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | unc-51 36 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATG1 35 37 |
|
OneToMany |
- Species where no ortholog for ULK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ULK2 Gene
(31) SIMAP similar genes for ULK2 Gene using alignment to 4 proteins:
Variants for ULK2 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041282 | A metastatic melanoma sample | ||||
| VAR_041283 | A metastatic melanoma sample | ||||
| rs193921089 | Uncertain significance | 19,845,333(-) | TGGCT(G/T)CAACA | nc-transcript-variant, reference, missense, utr-variant-5-prime | |
| rs1000034249 | -- | 19,856,990(+) | AAAAA(A/C)AAAAA | intron-variant | |
| rs1000071911 | -- | 19,818,806(+) | TTTTT(C/T)TTTTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2649888 | CNV | deletion | 19546169 |
| esv3640183 | CNV | loss | 21293372 |
| nsv1061317 | CNV | gain | 25217958 |
| nsv1063892 | CNV | gain | 25217958 |
| nsv1138505 | CNV | deletion | 24896259 |
| nsv2002 | CNV | insertion | 18451855 |
| nsv510435 | OTHER | sequence alteration | 20534489 |
| nsv960436 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
9.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.52;
55.58% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ULK2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK2 Gene
Disorders for ULK2 Gene
Relevant External Links for ULK2
No disorders were found for ULK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK2 Gene
Publications for ULK2 Gene
- Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. (PMID: 10557072) Yan J. … Muramatsu M. (Oncogene 1999) 2 3 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PMID: 18936157) Chan E.Y.W. … Tooze S.A. (Mol. Cell. Biol. 2009) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4 64
Products for ULK2 Gene
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- OriGene Purified Proteins for ULK2
- Search Origene for MassSpec and Protein Over-expression Lysates for ULK2
- Origene Custom Protein Services for ULK2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ULK2
- Browse OriGene Inhibitory RNA Products For ULK2
- OriGene qPCR primer pairs and template standards for ULK2
- OriGene qPCR primer pairs for ULK2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ULK2
- GenScript: Next-day shipping cDNA ORF clone for ULK2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ULK2
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- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Gene Mutant Library, Variants up to 10^11
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- Novus Biologicals Antibodies for ULK2
- Novus Biologicals proteins and lysates for ULK2
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- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for ULK2
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for ULK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ULK2
- antibodies-online Antibodies for ULK2: See all 113
- Search antibodies-online for kits
- antibodies-online Proteins for ULK2: See all 3
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- GeneTex ULK2 antibody for ULK2
- GeneTex Dpm1 antibody for ULK2
- Search GeneTex for Proteins for ULK2
- ViGene Biosciences adenoviral particle packaged cDNA for ULK2 gene
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- Search ViGene Biosciences for ULK2
- Santa Cruz Biotechnology (SCBT) Antibodies for ULK2
- Search Santa Cruz Biotechnology (SCBT) for ULK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ULK2
- Custom Antibody ServicesProSci Antibodies for ULK2
- Search for ULK2 Proteins at ProSci
- Horizon Cell Lines for ULK2
- Cyagen custom Knockout/knockin (KOKI) mouse models for ULK2
- VectorBuilder custom plasmid, inducible vectors for ULK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ULK2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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