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Aliases for ULK1 Gene

Aliases for ULK1 Gene

  • Unc-51 Like Autophagy Activating Kinase 1 2 3 5
  • Autophagy-Related Protein 1 Homolog 3 4
  • EC 2.7.11.1 4 63
  • HATG1 3 4
  • ATG1 3 4
  • ATG1 Autophagy Related 1 Homolog (S. Cerevisiae) 2
  • Unc-51 (C. Elegans)-Like Kinase 1 2
  • Unc-51-Like Kinase 1 (C. Elegans) 2
  • ATG1 Autophagy Related 1 Homolog 3
  • Unc-51-Like Kinase 1 4
  • EC 2.7.11 63
  • KIAA0722 4
  • Unc51.1 3
  • ATG1A 3
  • UNC51 3

External Ids for ULK1 Gene

Previous GeneCards Identifiers for ULK1 Gene

  • GC12U990117
  • GC12M131722
  • GC12P132259
  • GC12P130873
  • GC12P131045
  • GC12P130945
  • GC12P132379
  • GC12P129276

Summaries for ULK1 Gene

GeneCards Summary for ULK1 Gene

ULK1 (Unc-51 Like Autophagy Activating Kinase 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence and AMPK signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK3.

UniProtKB/Swiss-Prot for ULK1 Gene

  • Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

Gene Wiki entry for ULK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK1 Gene

Genomics for ULK1 Gene

Regulatory Elements for ULK1 Gene

Promoters for ULK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ULK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ULK1 Gene

Chromosome:
12
Start:
131,894,651 bp from pter
End:
131,923,167 bp from pter
Size:
28,517 bases
Orientation:
Plus strand

Genomic View for ULK1 Gene

Genes around ULK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK1 Gene

Proteins for ULK1 Gene

  • Protein details for ULK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75385-ULK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK1
    Protein Accession:
    O75385
    Secondary Accessions:
    • Q9UQ28

    Protein attributes for ULK1 Gene

    Size:
    1050 amino acids
    Molecular mass:
    112631 Da
    Quaternary structure:
    • Interacts with GABARAP and GABARAPL2. Interacts (via C-terminus) with ATG13. Part of a complex consisting of ATG13, ATG101, ULK1 and RB1CC1. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation. Interacts with FEZ1; SCOC interferes with FEZ1-binding. Interacts with TBC1D14. Interacts (phosphorylated form) with TRIM5 (PubMed:25127057). When phosphorylated at Ser-317, interacts with MEFV and BECN1 simultaneously. Interacts with TRIM21 and IRF3, in the presence of TRIM21 (PubMed:26347139).
    SequenceCaution:
    • Sequence=BAA34442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ULK1 Gene

neXtProt entry for ULK1 Gene

Proteomics data for ULK1 Gene at MOPED

Selected DME Specific Peptides for ULK1 Gene

Post-translational modifications for ULK1 Gene

  • Autophosphorylated. Phosphorylated under nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). In response to nutrient limitation, phosphorylated and activated by AMPK, leading to activate autophagy.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ULK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ULK1 (ULK1)

Domains & Families for ULK1 Gene

Gene Families for ULK1 Gene

Suggested Antigen Peptide Sequences for ULK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75385

UniProtKB/Swiss-Prot:

ULK1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
genes like me logo Genes that share domains with ULK1: view

Function for ULK1 Gene

Molecular function for ULK1 Gene

GENATLAS Biochemistry:
C elegans UNC51-like kinase 1,112.6kDa,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

Enzyme Numbers (IUBMB) for ULK1 Gene

Gene Ontology (GO) - Molecular Function for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IPI 19211835
genes like me logo Genes that share ontologies with ULK1: view
genes like me logo Genes that share phenotypes with ULK1: view

Animal Models for ULK1 Gene

MGI Knock Outs for ULK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ULK1

miRNA for ULK1 Gene

miRTarBase miRNAs that target ULK1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK1 Gene

Localization for ULK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULK1 Gene

Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULK1 Gene COMPARTMENTS Subcellular localization image for ULK1 gene
Compartment Confidence
cytosol 5
vacuole 5
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
nucleus 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 9693035
genes like me logo Genes that share ontologies with ULK1: view

Pathways & Interactions for ULK1 Gene

genes like me logo Genes that share pathways with ULK1: view

Pathways by source for ULK1 Gene

2 GeneTex pathways for ULK1 Gene
2 BioSystems pathways for ULK1 Gene
2 Reactome pathways for ULK1 Gene

SIGNOR curated interactions for ULK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,NAS 9693035
GO:0007165 signal transduction IEA --
GO:0008104 protein localization IMP 16940348
GO:0010506 regulation of autophagy IMP 17595159
GO:0016236 macroautophagy TAS --
genes like me logo Genes that share ontologies with ULK1: view

Drugs & Compounds for ULK1 Gene

(1) Drugs for ULK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for ULK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ULK1: view

Transcripts for ULK1 Gene

Unigene Clusters for ULK1 Gene

Unc-51-like kinase 1 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 21a · 21b ^ 22a · 22b · 22c
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for ULK1 Gene

GeneLoc Exon Structure for
ULK1
ECgene alternative splicing isoforms for
ULK1

Expression for ULK1 Gene

mRNA expression in normal human tissues for ULK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ULK1 Gene

This gene is overexpressed in Frontal cortex (20.6), Fetal gut (13.8), Adipocyte (11.6), Blymphocyte (11.1), and Heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ULK1 Gene



SOURCE GeneReport for Unigene cluster for ULK1 Gene Hs.47061

mRNA Expression by UniProt/SwissProt for ULK1 Gene

O75385-ULK1_HUMAN
Tissue specificity: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
genes like me logo Genes that share expression patterns with ULK1: view

Protein tissue co-expression partners for ULK1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ULK1 Gene

Orthologs for ULK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ULK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ULK1 35
  • 88.05 (n)
  • 90.37 (a)
ULK1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ULK1 35
  • 85.59 (n)
  • 89.25 (a)
ULK1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ulk1 35
  • 83.73 (n)
  • 90.16 (a)
Ulk1 16
Ulk1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ULK1 35
  • 92.73 (n)
  • 91.55 (a)
rat
(Rattus norvegicus)
Mammalia Ulk1 35
  • 83.6 (n)
  • 89.78 (a)
oppossum
(Monodelphis domestica)
Mammalia ULK1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ULK1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ULK1 35
  • 73.03 (n)
  • 76.84 (a)
ULK1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ULK1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk1 35
  • 67.18 (n)
  • 71.35 (a)
zebrafish
(Danio rerio)
Actinopterygii ulk1b 35
  • 65.96 (n)
  • 64.5 (a)
ulk1a 36
  • 55 (a)
OneToMany
ulk1b 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8866 37
  • 39 (a)
Atg1 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-51 37
  • 60 (a)
unc-51 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3319 36
  • 25 (a)
ManyToMany
Species with no ortholog for ULK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ULK1 Gene

ENSEMBL:
Gene Tree for ULK1 (if available)
TreeFam:
Gene Tree for ULK1 (if available)

Paralogs for ULK1 Gene

Paralogs for ULK1 Gene

genes like me logo Genes that share paralogs with ULK1: view

Variants for ULK1 Gene

Sequence variations from dbSNP and Humsavar for ULK1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_041274 An ovarian mucinous carcinoma sample
rs56364352 - 131,910,745(+) AAGCT(C/T)GGGGT nc-transcript-variant, reference, missense
rs12827141 - 131,915,142(+) CAGCC(C/T)CTCGC nc-transcript-variant, reference, missense
rs55824543 - 131,915,217(+) CTACA(C/T)GCCAT nc-transcript-variant, reference, missense
rs55815560 - 131,916,513(+) CCTCT(C/T)GGAGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ULK1 Gene

Variant ID Type Subtype PubMed ID
nsv899699 CNV Gain 21882294
nsv455803 CNV Gain 19166990
nsv832555 CNV Loss 17160897
esv2751042 CNV Gain 17911159
dgv1516n71 CNV Loss 21882294
nsv826561 CNV Gain 20364138
nsv455804 CNV Loss 19166990
nsv9045 CNV Gain+Loss 18304495
esv990859 CNV Deletion 20482838
dgv1517n71 CNV Loss 21882294
nsv899707 CNV Loss 21882294
nsv899710 CNV Loss 21882294
nsv942 CNV Insertion 18451855
nsv899711 CNV Loss 21882294
nsv899712 CNV Loss 21882294
esv2746906 CNV Deletion 23290073
esv2274339 CNV Deletion 18987734

Variation tolerance for ULK1 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULK1 Gene

HapMap Linkage Disequilibrium report
ULK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK1 Gene

Disorders for ULK1 Gene

Relevant External Links for ULK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULK1

No disorders were found for ULK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK1 Gene

Publications for ULK1 Gene

  1. Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. (PMID: 9693035) Kuroyanagi H. … Shirasawa T. (Genomics 1998) 2 3 4 23 67
  2. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PMID: 18936157) Chan E.Y.W. … Tooze S.A. (Mol. Cell. Biol. 2009) 3 23
  3. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. (PMID: 19225151) Jung C.H. … Kim D.H. (Mol. Biol. Cell 2009) 3 23
  4. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PMID: 19287211) Mercer C.A. … Dennis P.B. (Autophagy 2009) 3 23
  5. mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex. (PMID: 19690328) Chan E.Y. (Sci Signal 2009) 3 23

Products for ULK1 Gene

Sources for ULK1 Gene

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