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ULK1 Gene

protein-coding   GIFtS: 65
GCID: GC12P132379

Unc-51 Like Autophagy Activating Kinase 1

(Previous names: unc-51 (C. elegans)-like kinase 1, unc-51-like kinase 1...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unc-51 Like Autophagy Activating Kinase 11 2     Unc-51-Like Kinase 1 (C. Elegans)1
Autophagy-Related Protein 1 Homolog2 3     ATG1A2
ATG12 3     Unc51.12
hATG12 3     ATG1 Autophagy Related 1 Homolog2
EC 2.7.11.13 8     Serine/Threonine-Protein Kinase ULK12
UNC512 5     KIAA07223
ATG1 Autophagy Related 1 Homolog (S. Cerevisiae)1     Unc-51-Like Kinase 13
Unc-51 (C. Elegans)-Like Kinase 11     EC 2.7.118

External Ids:    HGNC: 125581   Entrez Gene: 84082   Ensembl: ENSG000001771697   OMIM: 6031685   UniProtKB: O753853   

Export aliases for ULK1 gene to outside databases

Previous GC identifers: GC12U990117 GC12M131722 GC12P132259 GC12P130873 GC12P131045 GC12P130945 GC12P129276


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ULK1 Gene:
ULK1 (unc-51 like autophagy activating kinase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein complex binding. An important paralog of this gene is PDIK1L.

UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385
Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of
phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of
autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative
regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via
phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits
PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and
RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is
required for granule cell axon formation

Gene Wiki entry for ULK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ULK1 gene promoter:
         Sp1   SREBP-1c   SREBP-1b   CBF-B   SREBP-1a   CBF-A   Zic1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidULK1 promoter sequence
   Search Chromatin IP Primers for ULK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ULK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.3

ULK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132379:  view genomic region     (about GC identifiers)

Start:
132,379,196 bp from pter      End:
132,407,712 bp from pter
Size:
28,517 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase ULK1  
Size: 1050 amino acids; 112631 Da
Subunit: Interacts with GABARAP and GABARAPL2. Interacts (via C-terminus) with ATG13. Part of a complex consisting
of ATG13, ATG101, ULK1 and RB1CC1. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through
an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation.
Interacts with FEZ1; SCOC interferes with FEZ1-binding. Interacts with TBC1D14
Sequence caution: Sequence=BAA34442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9UQ28

Explore the universe of human proteins at neXtProt for ULK1: NX_O75385

Explore proteomics data for ULK1 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylated under nutrient-rich conditions; dephosphorylated during starvation or following
    treatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction
    with AMPK and preventing activation of ULK1 (By similarity). In response to nutrient limitation, phosphorylated
    and activated by AMPK, leading to activate autophagy1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ULK1 (O75385)
     HRDLKPQN  KIADFGFAR  KEIKILKEL  MAATLCGSPMYMAPEVIMS 


    See ULK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003556.1  
    ENSEMBL proteins: 
     ENSP00000324560   ENSP00000438953   ENSP00000444983   ENSP00000444298   ENSP00000441794  

    ULK1 Human Recombinant Protein Products:

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    antibodies-online proteins for ULK1 (3 products) 

     
    antibodies-online peptides for ULK1

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    antibodies-online antibodies for ULK1 (125 products) 

    ULK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: unc-51-like kinase 1 (C. elegans)
    Unc-51-like kinase (ULK) family

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR016237 Ser/Thr_kin_STPK_Ulk-1/2
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry O75385

    ProtoNet protein and cluster: O75385

    UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with ULK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ULK1_HUMAN, O75385
    Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of
    phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of
    autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative
    regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via
    phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits
    PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and
    RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is
    required for granule cell axon formation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for ULK1:
    C elegans UNC51-like kinase 1,112.6kDa,ubiquitously expressed

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity NAS9693035
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11146101
         
    Find genes that share ontologies with ULK1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ULK1:
     Decreased cilium length after   Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ulk1):
     cellular  hematopoietic system  immune system  mortality/aging  no phenotypic analysis 
     vision/eye 

    Find genes that share phenotypes with ULK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ulk1tm1.1Thsn for ULK1

       genOway: Develop your customized and physiologically relevant rodent model for ULK1

    miRNA
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    miRTarBase miRNAs that target ULK1:
    hsa-mir-186-5p (MIRT045246), hsa-mir-423-5p (MIRT038087), hsa-mir-16-5p (MIRT051250), hsa-mir-320a (MIRT044753), hsa-mir-335-5p (MIRT017081)

    Block miRNA regulation of human, mouse, rat ULK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ULK1 (see all 43):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-25 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidULK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ULK1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ULK1 (NM_003565)
    Sino Biological Human cDNA Clone for ULK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK1
    Addgene plasmids for ULK1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ULK1_HUMAN, O75385: Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Under
    starvation conditions, is localized to puncate structures primarily representing the isolation membrane that
    sequesters a portion of the cytoplasm resulting in the formation of an autophagosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    vacuole5
    endosome2
    lysosome2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure ----
    GO:0005737cytoplasm NAS9693035
    GO:0005776autophagic vacuole IDA17595159
    GO:0005829cytosol IDA11146101
    GO:0016020membrane ----

    Find genes that share ontologies with ULK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ULK1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    2Insulin receptor signalling cascade
    TOR signaling0.32
    3Senescence and Autophagy
    Senescence and Autophagy
    4Regulation of autophagy
    Regulation of autophagy
    5Neuroscience
    Neuroscience


    Find genes that share SuperPaths with ULK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ULK1
        Neuroscience
    Glucose / Energy Metabolism

    2 BioSystems Pathways for ULK1
        TOR signaling
    Senescence and Autophagy



    2 Kegg Pathways  (Kegg details for ULK1):
        Regulation of autophagy
    mTOR signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ULK1: 
              mTOR Signaling in human mouse rat
              Autophagy in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ULK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ULK1 (O753851, 2, 3 ENSP000003245604) via UniProtKB, MINT, STRING, and/or I2D (see all 407)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IEA--
    GO:0006468protein phosphorylation NAS9693035
    GO:0007165signal transduction ----
    GO:0007265Ras protein signal transduction IEA--
    GO:0007409axonogenesis ----

    Find genes that share ontologies with ULK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ULK1

    2 HMDB Compounds for ULK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ULK1 gene: 
    NM_003565.2  

    Unigene Cluster for ULK1:

    Unc-51-like kinase 1 (C. elegans)
    Hs.47061  [show with all ESTs]
    Unigene Representative Sequence: NM_003565
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321867(uc001uje.3) ENST00000537421 ENST00000542313 ENST00000541761
    ENST00000540647 ENST00000544718 ENST00000540568
    miRNA
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    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-25 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidULK1 3' UTR sequence
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    Addgene plasmids for ULK1 
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      QuantiFast Probe-based Assays in human, mouse, rat ULK1

    Additional mRNA sequence: 

    AB018265.2 AF045458.1 AK095774.1 

    9 DOTS entries:

    DT.115406  DT.92434909  DT.100813590  DT.100813587  DT.92434911  DT.101967798  DT.121165248  DT.92434908 
    DT.99957950 

    Selected AceView cDNA sequences (see all 230):

    BU859202 AI564963 AA402199 BQ002124 BM544069 AA759143 AA455505 BF792088 
    AI917150 BM920397 AA917627 BM543798 AI863647 AA722443 AA907219 BM473907 
    BU069523 AI399738 AA478422 BE964399 AL040487 AA402913 BM272372 BG763633 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ULK1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22a · 22b · 22c
    SP1:                              
    SP2:                              
    SP3:  -                           
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ULK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ULK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGTGTGTC
    ULK1 Expression
    About this image


    ULK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    ULK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ULK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.47061

    UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385
    Tissue specificity: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart,
    pancreas, brain, placenta, liver, kidney, and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ULK1: 
              mTOR Signaling in human mouse rat
              Autophagy in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ULK1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ULK1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ulk11 , 5 Unc-51 like kinase 1 (C. elegans)5
    unc-51 like kinase 11
    83.73(n)1
    90.16(a)1
      5 (53.70 cM)5
    222411  NM_009469.31  NP_033495.21 
     1107844895 
    chicken
    (Gallus gallus)
    Aves ULK11 unc-51-like kinase 1 (C. elegans) 73.03(n)
    76.84(a)
      416800  XM_415091.4  XP_415091.2 
    lizard
    (Anolis carolinensis)
    Reptilia ULK16
    unc-51 like autophagy activating kinase 1
    70(a)
    1 ↔ 1
    GL343364.1(113177-145888)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ulk11 unc-51 like autophagy activating kinase 1 67.18(n)
    71.35(a)
      100127200  NM_001112917.1  NP_001106388.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ulk1b1 unc-51-like kinase 1b (C. elegans) 65.96(n)
    64.5(a)
      558848  XM_002665925.3  XP_002665971.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88663 protein amino acid phosphorylation
    protein kinase
    39(a)   85D11   --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-513 serine/threonine protein kinase 60(a)   V(19988350-19996523)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG16
    Protein ser/thr kinase required for vesicle format...
    24(a)
    1 → many
    VII(160065-162758) YGL180W


    ENSEMBL Gene Tree for ULK1 (if available)
    TreeFam Gene Tree for ULK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ULK1 gene
    PDIK1L2  STK332  ULK22  ULK32  STK352  
    Selected SIMAP similar genes for ULK1 using alignment to 5 protein entries:     ULK1_HUMAN (see all proteins) (see all similar genes):
    RPS6KA1    SGK494    CDK12    CSNK1D    CSNK1G2    PKN2
    NEK9    PHKG2    MAPK14    PRKACA    PRKCH    MAP3K11
    RPS6KA2    AKT2    CSNK2A3    DKFZp564L2416    MINK1    NEK8

    Find genes that share paralogs with ULK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ULK1 (see all 939)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412744
    An ovarian mucinous carcinoma sample4--see VAR_0412742 V M mis40--------
    VAR_0412804
    A lung adenocarcinoma sample4--see VAR_0412802 S C mis40--------
    rs1932159011,2
    --132377299(+) CTGGGG/TTTCCC 1 -- us2k10--------
    rs1835152071,2
    C--132377319(+) TCCAGA/GAGTAC 1 -- us2k10--------
    rs1397275591,2
    C--132377346(+) AGCAA-/TCTCGG 1 -- us2k10--------
    rs1885570421,2
    --132377350(+) ATCTCA/GGCCCT 1 -- us2k10--------
    rs765290011,2
    C,F--132377383(+) AGCACG/ATAGCC 1 -- us2k12Minor allele frequency- A:0.05WA 120
    rs781729031,2
    C,F--132377485(+) GCAGGC/TGGGTC 1 -- us2k12Minor allele frequency- T:0.34NA EA 240
    rs757037241,2
    C,F--132377488(+) GGCGGG/ATCTTG 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1489854391,2
    --132377598(+) GACTAC/TGGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ULK1 (132379196 - 132407712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ULK1 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv990859CNV Deletion20482838
    esv2746906CNV Deletion23290073
    esv2274339CNV Deletion18987734
    nsv942CNV Insertion18451855
    nsv899707CNV Loss21882294
    dgv1517n71CNV Loss21882294
    nsv899711CNV Loss21882294
    nsv455804CNV Loss19166990
    nsv899710CNV Loss21882294
    nsv899712CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ULK1
    DNA2.0 Custom Variant and Variant Library Synthesis for ULK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603168    OMIM disorders: --


    Find genes that share disorders with ULK1           About GenesLikeMe


    Export disorders for ULK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ULK1 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with ULK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. (PubMed id 9693035)1, 2, 3, 9 Kuroyanagi H.... Shirasawa T. (Genomics 1998)
    2. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PubMed id 19287211)1, 2, 9 Mercer C.A.... Dennis P.B. (Autophagy 2009)
    3. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PubMed id 18936157)1, 2, 9 Chan E.Y.W.... Tooze S.A. (Mol. Cell. Biol. 2009)
    4. TBC1D14 regulates autophagosome formation via Rab11- and ULK1- positive recycling endosomes. (PubMed id 22613832)1, 2 Longatti A.... Tooze S.A. (J. Cell Biol. 2012)
    5. ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. (PubMed id 21795849)1, 2 Jung C.H.... Kim D.H. (Autophagy 2011)
    6. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PubMed id 21460634)1, 2 Loffler A.S.... Stork B. (Autophagy 2011)
    7. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. (PubMed id 21205641)1, 2 Egan D.F.... Shaw R.J. (Science 2011)
    8. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (PubMed id 19211835)1, 2 Hosokawa N....Mizushima N. (Mol. Biol. Cell 2009)
    9. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. (PubMed id 11146101)1, 2 Okazaki N.... Muramatsu M.-A. (Brain Res. Mol. Brain Res. 2000)
    10. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8408 HGNC: 12558 AceView: ULK1 Ensembl:ENSG00000177169 euGenes: HUgn8408
    ECgene: ULK1 Kegg: 8408 H-InvDB: ULK1

    (According to HUGE)
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    HUGE: KIAA0722

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ULK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ULK1 gene:
    Search GeneIP for patents involving ULK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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