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Aliases for ULK1 Gene

Aliases for ULK1 Gene

  • Unc-51 Like Autophagy Activating Kinase 1 2 3 5
  • Autophagy-Related Protein 1 Homolog 3 4
  • EC 2.7.11.1 4 61
  • HATG1 3 4
  • ATG1 3 4
  • ATG1 Autophagy Related 1 Homolog (S. Cerevisiae) 2
  • Serine/Threonine-Protein Kinase ULK1 3
  • Unc-51 (C. Elegans)-Like Kinase 1 2
  • Unc-51-Like Kinase 1 (C. Elegans) 2
  • ATG1 Autophagy Related 1 Homolog 3
  • Unc-51-Like Kinase 1 4
  • EC 2.7.11 61
  • KIAA0722 4
  • Unc51.1 3
  • ATG1A 3
  • UNC51 3

External Ids for ULK1 Gene

Previous GeneCards Identifiers for ULK1 Gene

  • GC12U990117
  • GC12M131722
  • GC12P132259
  • GC12P130873
  • GC12P131045
  • GC12P130945
  • GC12P132379
  • GC12P129276

Summaries for ULK1 Gene

GeneCards Summary for ULK1 Gene

ULK1 (Unc-51 Like Autophagy Activating Kinase 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Cellular Senescence. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK2.

UniProtKB/Swiss-Prot for ULK1 Gene

  • Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Gene Wiki entry for ULK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK1 Gene

Genomics for ULK1 Gene

Regulatory Elements for ULK1 Gene

Enhancers for ULK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F131859 1.8 FANTOM5 Ensembl ENCODE 2.2 -32.5 -32531 4.7 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 EP400 SFSWAP GOLGA3 DDX51 MMP17 RNU6-1017P ULK1 ENSG00000256955
GH12F132162 1.4 FANTOM5 Ensembl ENCODE 2.7 +268.3 268250 1.8 CTCF KLF1 KLF17 MAX ZIC2 HIC1 ZNF664 ZNF23 ZNF316 GLIS2 DDX51 EP400NL ULK1 FBRSL1 SFSWAP LOC105370090 GC12P132155
GH12F131871 1.5 FANTOM5 Ensembl ENCODE 1.8 -22.1 -22070 2.8 PKNOX1 ZFP64 KLF17 SIN3A RAD21 GLIS2 RCOR1 FOS EGR2 SMARCC1 MMP17 PUS1 ENSG00000255992 EP400 RNU6-1017P SFSWAP ULK1 ENSG00000256955
GH12F131718 0.5 FANTOM5 4.7 -175.7 -175743 0.1 ZFHX2 EGR2 ULK1 SFSWAP ENSG00000255933
GH12F131893 1.1 ENCODE 0.8 +1.5 1482 4.3 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 SP3 EP400 GOLGA3 ENSG00000279283 ULK1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ULK1 on UCSC Golden Path with GeneCards custom track

Promoters for ULK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001468513 649 3001 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 SP3

Genomic Location for ULK1 Gene

Chromosome:
12
Start:
131,894,651 bp from pter
End:
131,923,167 bp from pter
Size:
28,517 bases
Orientation:
Plus strand

Genomic View for ULK1 Gene

Genes around ULK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK1 Gene

Proteins for ULK1 Gene

  • Protein details for ULK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75385-ULK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK1
    Protein Accession:
    O75385
    Secondary Accessions:
    • Q9UQ28

    Protein attributes for ULK1 Gene

    Size:
    1050 amino acids
    Molecular mass:
    112631 Da
    Quaternary structure:
    • Interacts with GABARAP and GABARAPL2. Interacts (via C-terminus) with ATG13. Part of a complex consisting of ATG13, ATG101, ULK1 and RB1CC1. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation. Interacts with FEZ1; SCOC interferes with FEZ1-binding. Interacts with TBC1D14. Interacts (phosphorylated form) with TRIM5 (PubMed:25127057). When phosphorylated at Ser-317, interacts with MEFV and BECN1 simultaneously. Interacts with TRIM21 and IRF3, in the presence of TRIM21 (PubMed:26347139). Interacts with SESN2 (PubMed:25040165). Interacts with SQSTM1 (PubMed:25040165).
    SequenceCaution:
    • Sequence=BAA34442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ULK1 Gene

neXtProt entry for ULK1 Gene

Selected DME Specific Peptides for ULK1 Gene

O75385:
  • KEIKILKEL
  • HRDLKPQN
  • MAATLCGSPMYMAPEVIMS
  • KIADFGFAR

Post-translational modifications for ULK1 Gene

  • Autophosphorylated. Phosphorylated under nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). In response to nutrient limitation, phosphorylated and activated by AMPK, leading to activate autophagy.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ULK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ULK1 (ULK1)
  • Abcam antibodies for ULK1
  • Santa Cruz Biotechnology (SCBT) Antibodies for ULK1

Domains & Families for ULK1 Gene

Gene Families for ULK1 Gene

Suggested Antigen Peptide Sequences for ULK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75385

UniProtKB/Swiss-Prot:

ULK1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
genes like me logo Genes that share domains with ULK1: view

Function for ULK1 Gene

Molecular function for ULK1 Gene

GENATLAS Biochemistry:
C elegans UNC51-like kinase 1,112.6kDa,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Enzyme Numbers (IUBMB) for ULK1 Gene

Gene Ontology (GO) - Molecular Function for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity NAS,TAS --
GO:0005515 protein binding IPI 11146101
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with ULK1: view
genes like me logo Genes that share phenotypes with ULK1: view

Animal Models for ULK1 Gene

MGI Knock Outs for ULK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ULK1

miRNA for ULK1 Gene

miRTarBase miRNAs that target ULK1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ULK1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK1 Gene

Localization for ULK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULK1 Gene

Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ULK1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
endosome 5
mitochondrion 2
nucleus 2
lysosome 2
cytoskeleton 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IEA --
GO:0005737 cytoplasm NAS 9693035
GO:0005776 autophagosome IDA 17595159
GO:0005829 cytosol IEA,TAS --
GO:0034045 pre-autophagosomal structure membrane IDA 18936157
genes like me logo Genes that share ontologies with ULK1: view

Pathways & Interactions for ULK1 Gene

genes like me logo Genes that share pathways with ULK1: view

Pathways by source for ULK1 Gene

2 GeneTex pathways for ULK1 Gene
2 Cell Signaling Technology pathways for ULK1 Gene
2 BioSystems pathways for ULK1 Gene

SIGNOR curated interactions for ULK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,NAS 9693035
GO:0006914 autophagy IEA,IMP 17595159
GO:0007165 signal transduction IEA --
GO:0007409 axonogenesis IEA --
GO:0008104 protein localization IMP 16940348
genes like me logo Genes that share ontologies with ULK1: view

Drugs & Compounds for ULK1 Gene

(2) Drugs for ULK1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
SBI-0206965 Pharma ULK1 inhibitor 0

(1) Additional Compounds for ULK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for ULK1 Gene

Compound Action Cas Number
SBI-0206965 ULK1 inhibitor 1538604-68-0
genes like me logo Genes that share compounds with ULK1: view

Transcripts for ULK1 Gene

Unigene Clusters for ULK1 Gene

Unc-51-like kinase 1 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ULK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 21a · 21b ^ 22a · 22b · 22c
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for ULK1 Gene

GeneLoc Exon Structure for
ULK1
ECgene alternative splicing isoforms for
ULK1

Expression for ULK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ULK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ULK1 Gene

This gene is overexpressed in Frontal cortex (20.6), Fetal gut (13.8), Adipocyte (11.6), Blymphocyte (11.1), and Heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ULK1 Gene



Protein tissue co-expression partners for ULK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ULK1 Gene:

ULK1

SOURCE GeneReport for Unigene cluster for ULK1 Gene:

Hs.47061

mRNA Expression by UniProt/SwissProt for ULK1 Gene:

O75385-ULK1_HUMAN
Tissue specificity: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
genes like me logo Genes that share expression patterns with ULK1: view

Primer Products

No data available for mRNA differential expression in normal tissues for ULK1 Gene

Orthologs for ULK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ULK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULK1 34
  • 92.73 (n)
cow
(Bos Taurus)
Mammalia ULK1 34 35
  • 88.05 (n)
dog
(Canis familiaris)
Mammalia ULK1 34 35
  • 85.59 (n)
mouse
(Mus musculus)
Mammalia Ulk1 34 16 35
  • 83.73 (n)
rat
(Rattus norvegicus)
Mammalia Ulk1 34
  • 83.6 (n)
oppossum
(Monodelphis domestica)
Mammalia ULK1 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ULK1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ULK1 34 35
  • 73.03 (n)
lizard
(Anolis carolinensis)
Reptilia ULK1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk1 34
  • 67.18 (n)
zebrafish
(Danio rerio)
Actinopterygii ulk1b 34 35
  • 65.96 (n)
ulk1a 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8866 36
  • 39 (a)
Atg1 35
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-51 36 35
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG1 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3319 35
  • 25 (a)
ManyToMany
Species where no ortholog for ULK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ULK1 Gene

ENSEMBL:
Gene Tree for ULK1 (if available)
TreeFam:
Gene Tree for ULK1 (if available)

Paralogs for ULK1 Gene

Variants for ULK1 Gene

Sequence variations from dbSNP and Humsavar for ULK1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs370624303 An ovarian mucinous carcinoma sample 131,910,720(+) CACCC(A/G)TGCCT nc-transcript-variant, reference, missense
VAR_041280 A lung adenocarcinoma sample
rs10794446 -- 131,893,419(+) CGCAA(C/T)GTGTA upstream-variant-2KB
rs10902469 -- 131,893,588(+) ACAGG(C/G)ACATA upstream-variant-2KB
rs10902470 -- 131,899,890(+) TGAGG(C/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ULK1 Gene

Variant ID Type Subtype PubMed ID
nsv942 CNV insertion 18451855
nsv9045 CNV gain+loss 18304495
nsv832555 CNV loss 17160897
nsv826561 CNV gain 20364138
nsv560931 CNV loss 21841781
nsv560930 CNV loss 21841781
nsv560928 CNV gain 21841781
nsv560927 CNV gain 21841781
nsv455804 CNV loss 19166990
nsv455803 CNV gain 19166990
nsv1112629 CNV deletion 24896259
nsv1069723 CNV deletion 25765185
esv990859 CNV deletion 20482838
esv3631282 CNV gain 21293372
esv3631281 CNV gain 21293372
esv3427251 CNV insertion 20981092
esv2751042 CNV gain 17911159
esv2746906 CNV deletion 23290073
esv2274339 CNV deletion 18987734

Variation tolerance for ULK1 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ULK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK1 Gene

Disorders for ULK1 Gene

Relevant External Links for ULK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULK1

No disorders were found for ULK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK1 Gene

Publications for ULK1 Gene

  1. Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. (PMID: 9693035) Kuroyanagi H. … Shirasawa T. (Genomics 1998) 2 3 4 22 64
  2. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PMID: 18936157) Chan E.Y.W. … Tooze S.A. (Mol. Cell. Biol. 2009) 3 4 22 64
  3. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PMID: 19287211) Mercer C.A. … Dennis P.B. (Autophagy 2009) 3 4 22 64
  4. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. (PMID: 26347139) Kimura T. … Deretic V. (J. Cell Biol. 2015) 3 4 64
  5. Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. (PMID: 25040165) Ro S.H. … Lee J.H. (FEBS J. 2014) 3 4 64

Products for ULK1 Gene

Sources for ULK1 Gene

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