ULK1 Gene
protein-coding GIFtS: 61
GCID: GC12P132379
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|
unc-51-like kinase 1 (C. elegans)(Previous name: unc-51 (C. elegans)-like kinase 1 )
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Aliases
for ULK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Unc-51-Like Kinase 1 (C. Elegans)1 2 | | Unc-51 (C. Elegans)-Like Kinase 11 | | ATG11 2 3 | | Unc51.12 | | ATG1A1 2 | | ATG1 Autophagy Related 1 Homolog2 | | Autophagy-Related Protein 1 Homolog2 3 | | Serine/Threonine-Protein Kinase ULK12 | | HATG11 | | KIAA07223 | | EC 2.7.11.13 8 | | Unc-51-Like Kinase 13 | | UNC512 5 | | EC 2.7.118 |
Export aliases for ULK1 gene to outside databasesPrevious GC identifers: GC12U990117 GC12M131722 GC12P132259 GC12P130873 GC12P131045 GC12P130945 GC12P129276 |
Summaries
for ULK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream ofphosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes.Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammaliantarget of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also actsas a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negativelyregulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Playsa role early in neuronal differentiation and is required for granule cell axon formation
Gene Wiki entry for ULK1
|
Genomic Views
for ULK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ULK1 gene promoter:
Sp1 SREBP-1c SREBP-1b CBF-B SREBP-1a CBF-A Zic1 CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ULK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.3 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.3ULK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P132379: view genomic region
(about GC identifiers)
Start:
|
132,379,196 bp from pter |
End:
|
132,407,707 bp from pter |
Size:
|
28,512 bases |
Orientation:
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plus strand |
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Proteins
for ULK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase ULK1 Size: 1050 amino acids; 112631 Da
Subunit: Interacts with GABARAP and GABARAPL2. Interacts (via C-terminus) with ATG13/KIAA0652. Part of a complexconsisting of ATG13/KIAA0652, ULK1 and RB1CC1. Associates with the mammalian target of rapamycin complex 1 (mTORC1)through an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation.Interacts with FEZ1; SCOC interferes with FEZ1-binding. Interacts with TBC1D14
Subcellular location: Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Understarvation conditions, is localized to puncate structures primarily representing the isolation membrane thatsequesters a portion of the cytoplasm resulting in the formation of an autophagosome (By similarity)
Sequence caution: Sequence=BAA34442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9UQ28Explore the universe of human proteins at neXtProt for ULK1: NX_O75385
Post-translational modifications:
Autophosphorylated. Phosphorylated under nutrient-rich conditions; dephosphorylated during starvation or followingtreatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction withAMPK and preventing activation of ULK1 (By similarity). In response to nutrient limitation, phosphorylated andactivated by AMPK, leading to activate autophagy1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75385
4 DME Specific Peptides for ULK1 (O75385)
ULK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003556.1
ENSEMBL proteins: ENSP00000324560 ENSP00000438953 ENSP00000444983 ENSP00000439648 ENSP00000444298 ENSP00000441794 ENSP00000446219
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
ULK1 for ontologies About GeneDecksing
ULK1 Antibody Products:
Assay Products for ULK1: |
Protein
Domains /
Families
for ULK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ULK1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O75385ProtoNet protein and cluster: O75385 UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamilySimilarity: Contains 1 protein kinase domain |
Function
for ULK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream ofphosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes.Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammaliantarget of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also actsas a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negativelyregulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Playsa role early in neuronal differentiation and is required for granule cell axon formationCatalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for ULK1:C elegans UNC51-like kinase 1,112.6kDa,ubiquitously expressed
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ULK1 (NM_003565) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ULK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
ULK1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ULK1:
Animal Models:
Mouse knock-out Ulk1tm1.1Thsn for ULK1
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ulk1):
ULK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ULK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Neuroscience | | | 2 | Apoptosis and Autophagy | | | 3 | Senescence and Autophagy | | | 4 | Glucose / Energy Metabolism | | | 5 | mTOR signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Cell Signaling Technology (CST) Pathways for ULK1
2  BioSystems Pathways for ULK1
2 
Kegg Pathways (Kegg details for ULK1):
ULK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ULK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/329 Interacting proteins for ULK1 (O753851, 2, 3 ENSP000003245604) via UniProtKB, MINT, STRING, and/or I2D (see all 329)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table
ULK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ULK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ULK1
2 HMDB Compounds for ULK1 About this table
Search CenterWatch for drugs/clinical trials and news about ULK1
|
Transcripts
for ULK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ULK1 gene: NM_003565.2 Unigene Cluster for ULK1: Unc-51-like kinase 1 (C. elegans) Hs.47061 [show with all ESTs]Unigene Representative Sequence: NM_0035659 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321867(uc001uje.3) ENST00000537421 ENST00000542313 ENST00000538444
ENST00000541761 ENST00000540647 ENST00000544718 ENST00000542419 ENST00000540568
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ULK1 (NM_003565) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ULK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK1 |
Additional cDNA sequence: AB018265.2 AF045458.1 AK095774.1 9 DOTS entries: DT.115406 DT.92434909 DT.100813590 DT.100813587 DT.92434911 DT.101967798 DT.121165248 DT.92434908 DT.99957950 24/230 AceView cDNA sequences (see all 230): BM543798 BQ002124 AI564963 BU859202 BF792088 AA722443 AI399738 AI863647 AI917150 AA402199 BM544069 BM473907 AA759143 AA478422 AA917627 BU069523 AA455505 BM920397 AA907219 AI808158 BM544259 BM802726 AI149786 AA725729
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ULK1 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | · | 20c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b | ^ | 22a | · | 22b | · | 22c |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for ULK1
|
Expression
for ULK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ULK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCGTGTGTC
About this image
See ULK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ULK1
SOURCE GeneReport for Unigene cluster: Hs.47061
UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385Tissue specificity: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas,brain, placenta, liver, kidney, and lung
SABiosciences Expression via Pathway-Focused PCR Arrays including ULK1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ULK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ULK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK1 |
Orthologs
for ULK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ULK1 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ULK11 |
unc-51-like kinase 1 (C. elegans) |
73.03(n)
76.84(a) |
|
416800 XM_415091.3 XP_415091.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ULK16 |
-- |
70(a) |
1 ↔ 1 |
GL343364.1(113177-145888) |
zebrafish
(Danio rerio) |
Actinopterygii |
ulk1b1 |
unc-51-like kinase 1b (C. elegans) |
66.13(n)
64.77(a) |
|
558848 XM_002665925.2 XP_002665971.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG88663 |
protein amino acid phosphorylation protein
kinase |
39(a) |
|
85D11 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-513 |
serine/threonine protein kinase |
60(a) |
|
V(19988350-19996523) -- |
ENSEMBL Gene Tree for ULK1 (if available)
TreeFam Gene Tree for ULK1 (if available) |
Paralogs
for ULK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ULK1 gene
- PDIK1L2 STK362 STK332 ULK22 ULK32 STK352
18/83 SIMAP similar genes for ULK1 using alignment to 7 protein entries: ULK1_HUMAN (see all proteins)
(see all similar genes):RPS6KA1 SGK494 CDK12 CSNK1D CSNK1G2 PKN2
NEK9 PHKG2 MAPK14 PRKACA PRKCH WNK1
MAP3K11 PSKH1 RPS6KA2 AKT2 DKFZp564L2416 MINK1
ULK1 for paralogs About GeneDecksing
|
Genomic Variants
for ULK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ULK1 (132379196 - 132407707 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ULK1
3 CNVs: 30624 8742 4796
2 Indels: 33574 45007 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ULK1 |
|
Disorders
/ Diseases
for ULK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ULK1 for disorders About GeneDecksing
OMIM gene information: 603168
OMIM disorders: --
7  diseases for ULK1: About MalaCardscrohn's disease osteoarthritis pharyngitis esophagitis
pancreatitis neuronitis alcoholism
Export disorders for ULK1 gene to outside databases
|
Publications
for ULK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ULK1 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with ULK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. (PubMed id 9693035)1, 2, 3, 9 Kuroyanagi H.... Shirasawa T. (1998)
- Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PubMed id 18936157)1, 2, 9 Chan E.Y....Tooze S.A. (2009)
- TBC1D14 regulates autophagosome formation via Rab11- a nd ULK1-positive recycling endosomes. (PubMed id 22613832)1, 2 Longatti A....Tooze S.A. (2012)
- ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. (PubMed id 21795849)1, 2 Jung C.H.... Kim D.H. (2011)
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PubMed id 21460634)1, 2 Loffler A.S.... Stork B. (2011)
- Phosphorylation of ULK1 (hATG1) by AMP-activated prot ein kinase connects energy sensing to mitophagy. (PubMed id 21205641)1, 2 Egan D.F....Shaw R.J. (2011)
- Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (PubMed id 19211835)1, 2 Hosokawa N....Mizushima N. (2009)
- Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. (PubMed id 11146101)1, 2 Okazaki N.... Muramatsu M.-A. (2000)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PubMed id 19287211)1, 9 Mercer C.A.... Dennis P.B. (2009)
|
External Searches for ULK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ULK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ULK1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ULK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ULK1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ULK1 gene:
Search GeneIP for patents involving ULK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ULK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for ULK1 | | OriGene shRNA RFP for ULK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ULK1 | | | OriGene Protein Over-expression Lysate for ULK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ULK1 | | OriGene 3'-UTR Clone for ULK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ULK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ULK1 | | OriGene Custom Protein Services for ULK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ULK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ULK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULK1 |
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| | Antibodies & Assays for ULK1 |
| | | | Search Tocris compounds for ULK1 |
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 | | | ULK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK1 |
|  |  |  | | | | ThermoFisher Antibody for ULK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULK1 |
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