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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ULK1 Gene

protein-coding   GIFtS: 64
GCID: GC12P132379

Unc-51 Like Autophagy Activating Kinase 1

(Previous names: unc-51 (C. elegans)-like kinase 1, unc-51-like kinase 1...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Unc-51 Like Autophagy Activating Kinase 11 2     Unc-51-Like Kinase 1 (C. Elegans)1
Autophagy-Related Protein 1 Homolog2 3     ATG1A2
ATG12 3     Unc51.12
hATG12 3     ATG1 Autophagy Related 1 Homolog2
EC 2.7.11.13 8     Serine/Threonine-Protein Kinase ULK12
UNC512 5     KIAA07223
ATG1 Autophagy Related 1 Homolog (S. Cerevisiae)1     Unc-51-Like Kinase 13
Unc-51 (C. Elegans)-Like Kinase 11     EC 2.7.118

External Ids:    HGNC: 125581   Entrez Gene: 84082   Ensembl: ENSG000001771697   OMIM: 6031685   UniProtKB: O753853   

Export aliases for ULK1 gene to outside databases

Previous GC identifers: GC12U990117 GC12M131722 GC12P132259 GC12P130873 GC12P131045 GC12P130945 GC12P129276


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ULK1 Gene: 
ULK1 (unc-51 like autophagy activating kinase 1) is a protein-coding gene. Diseases associated with ULK1 include osteoarthritis, and crohn's disease, and among its related super-pathways are Transcription Receptor-mediated HIF regulation and mTOR signalling. GO annotations related to this gene include protein serine/threonine kinase activity and protein complex binding. An important paralog of this gene is PDIK1L.

UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385
Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of
phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of
autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative
regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via
phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits
PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and
RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is
required for granule cell axon formation

Gene Wiki entry for ULK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ULK1 gene promoter:
         Sp1   SREBP-1c   SREBP-1b   CBF-B   SREBP-1a   CBF-A   Zic1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidULK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ULK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.3

ULK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132379:  view genomic region     (about GC identifiers)

Start:
132,379,196 bp from pter      End:
132,407,712 bp from pter
Size:
28,517 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase ULK1  
Size: 1050 amino acids; 112631 Da
Subunit: Interacts with GABARAP and GABARAPL2. Interacts (via C-terminus) with ATG13. Part of a complex consisting
of ATG13, ATG101, ULK1 and RB1CC1. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through
an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation.
Interacts with FEZ1; SCOC interferes with FEZ1-binding. Interacts with TBC1D14
Subcellular location: Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Under
starvation conditions, is localized to puncate structures primarily representing the isolation membrane that
sequesters a portion of the cytoplasm resulting in the formation of an autophagosome (By similarity)
Sequence caution: Sequence=BAA34442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9UQ28

Explore the universe of human proteins at neXtProt for ULK1: NX_O75385

Explore proteomics data for ULK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated. Phosphorylated under nutrient-rich conditions; dephosphorylated during starvation or following
    treatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction
    with AMPK and preventing activation of ULK1 (By similarity). In response to nutrient limitation, phosphorylated
    and activated by AMPK, leading to activate autophagy
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75385

  • 4 DME Specific Peptides for ULK1 (O75385)
     HRDLKPQN  KIADFGFAR  KEIKILKEL  MAATLCGSPMYMAPEVIMS 

    ULK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ULK1 Protein Expression
    REFSEQ proteins: NP_003556.1  
    ENSEMBL proteins: 
     ENSP00000324560   ENSP00000438953   ENSP00000444983   ENSP00000444298   ENSP00000441794  

    Human Recombinant Protein Products for ULK1: 
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    Novus Biologicals ULK1 Proteins
    Novus Biologicals ULK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ULK1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure ----
    GO:0005737cytoplasm NAS9693035
    GO:0005776autophagic vacuole IDA17595159
    GO:0005829cytosol IDA11146101
    GO:0016020membrane ----

    ULK1 for ontologies           About GeneDecksing



    ULK1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ULK1
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    Assay Products for ULK1: 
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    Cloud-Clone Corp. ELISAs for ULK1 
    Cloud-Clone Corp. CLIAs for ULK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: unc-51-like kinase 1 (C. elegans) 
    Unc-51-like kinase (ULK) family

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR016237 Ser/Thr_kin_STPK_Ulk-1/2
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry O75385

    ProtoNet protein and cluster: O75385

    UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily
    Similarity: Contains 1 protein kinase domain


    ULK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ULK1_HUMAN, O75385
    Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of
    phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of
    autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative
    regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via
    phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits
    PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and
    RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is
    required for granule cell axon formation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for ULK1:
    C elegans UNC51-like kinase 1,112.6kDa,ubiquitously expressed

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity NAS9693035
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11146101
         
    ULK1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ULK1:
     Decreased cilium length after   Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ulk1):
     cellular  hematopoietic system  immune system  mortality/aging  no phenotypic analysis 

    ULK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ulk1tm1.1Thsn for ULK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ULK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ULK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ULK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ULK1 

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ULK1 (see all 43):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-25 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidULK1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ULK1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    2Energy dependent regulation of mTOR by LKB1-AMPK
    TOR signaling0.33
    3Senescence and Autophagy
    Senescence and Autophagy
    4Regulation of autophagy
    Regulation of autophagy
    5Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ULK1
        Neuroscience
    Glucose / Energy Metabolism

    2 BioSystems Pathways for ULK1
        TOR signaling
    Senescence and Autophagy



    2         Kegg Pathways  (Kegg details for ULK1):
        Regulation of autophagy
    mTOR signaling pathway


    ULK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ULK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/359 Interacting proteins for ULK1 (O753851, 2, 3 ENSP000003245604) via UniProtKB, MINT, STRING, and/or I2D (see all 359)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IEA--
    GO:0006468protein phosphorylation NAS9693035
    GO:0007165signal transduction ----
    GO:0007265Ras protein signal transduction IEA--
    GO:0007409axonogenesis ----

    ULK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ULK1

    2 HMDB Compounds for ULK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about ULK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ULK1 gene: 
    NM_003565.2  

    Unigene Cluster for ULK1:

    Unc-51-like kinase 1 (C. elegans)
    Hs.47061  [show with all ESTs]
    Unigene Representative Sequence: NM_003565
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321867(uc001uje.3) ENST00000537421 ENST00000542313 ENST00000541761
    ENST00000540647 ENST00000544718 ENST00000540568
    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ULK1 (see all 43):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-25 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidULK1 3' UTR sequence
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    Additional mRNA sequence: 

    AB018265.2 AF045458.1 AK095774.1 

    9 DOTS entries:

    DT.115406  DT.92434909  DT.100813590  DT.100813587  DT.92434911  DT.101967798  DT.121165248  DT.92434908 
    DT.99957950 

    24/230 AceView cDNA sequences (see all 230):

    AA455505 BM543798 BM920397 AA759143 BM473907 AA478422 AA917627 BU069523 
    AI564963 AA402199 BM544069 AI917150 AA722443 AA907219 BF792088 AI399738 
    BQ002124 BU859202 AI863647 BI335505 AI962901 BM544259 AI589138 AI470493 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ULK1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22a · 22b · 22c
    SP1:                              
    SP2:                              
    SP3:  -                           
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ULK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ULK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGTGTGTC
    ULK1 Expression
    About this image


    See ULK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ULK1

    SOURCE GeneReport for Unigene cluster: Hs.47061

    UniProtKB/Swiss-Prot: ULK1_HUMAN, O75385
    Tissue specificity: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart,
    pancreas, brain, placenta, liver, kidney, and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including ULK1: 
              mTOR Signaling in human mouse rat
              Autophagy in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ULK1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ulk11 , 5 Unc-51 like kinase 1 (C. elegans)5
    unc-51 like kinase 11
    83.73(n)1
    90.16(a)1
      5 (53.70 cM)5
    222411  NM_009469.31  NP_033495.21 
     1107844895 
    chicken
    (Gallus gallus)
    Aves ULK11 unc-51-like kinase 1 (C. elegans) 73.03(n)
    76.84(a)
      416800  XM_415091.3  XP_415091.2 
    lizard
    (Anolis carolinensis)
    Reptilia ULK16
    Uncharacterized protein
    70(a)
    1 ↔ 1
    GL343364.1(113177-145888)
    zebrafish
    (Danio rerio)
    Actinopterygii ulk1b1 unc-51-like kinase 1b (C. elegans) 66.13(n)
    64.77(a)
      558848  XM_002665925.2  XP_002665971.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88663 protein amino acid phosphorylation
    protein kinase
    39(a)   85D11   --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-513 serine/threonine protein kinase 60(a)   V(19988350-19996523)   --


    ENSEMBL Gene Tree for ULK1 (if available)
    TreeFam Gene Tree for ULK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ULK1 gene
    PDIK1L2  ULK22  ULK32  STK352  
    18/81 SIMAP similar genes for ULK1 using alignment to 7 protein entries:     ULK1_HUMAN (see all proteins) (see all similar genes):
    RPS6KA1    SGK494    CDK12    CSNK1D    CSNK1G2    PKN2
    NEK9    PHKG2    MAPK14    PRKACA    PRKCH    WNK1
    MAP3K11    RPS6KA2    AKT2    CSNK2A3    DKFZp564L2416    MINK1

    ULK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/939 SNPs in ULK1 are shown (see all 939)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412744
    An ovarian mucinous carcinoma sample4--see VAR_0412742 V M mis40--------
    VAR_0412804
    A lung adenocarcinoma sample4--see VAR_0412802 S C mis40--------
    VAR_0548924
    ----see VAR_0548922 T A mis40--------
    rs1932159011,2
    --132377299(+) CTGGGG/TTTCCC 1 -- us2k10--------
    rs1835152071,2
    C--132377319(+) TCCAGA/GAGTAC 1 -- us2k10--------
    rs1397275591,2
    C--132377346(+) AGCAA-/TCTCGG 1 -- us2k10--------
    rs1885570421,2
    --132377350(+) ATCTCA/GGCCCT 1 -- us2k10--------
    rs765290011,2
    C,F--132377383(+) AGCACG/ATAGCC 1 -- us2k12Minor allele frequency- A:0.05WA 120
    rs781729031,2
    C,F--132377485(+) GCAGGC/TGGGTC 1 -- us2k12Minor allele frequency- T:0.34NA EA 240
    rs757037241,2
    C,F--132377488(+) GGCGGG/ATCTTG 1 -- us2k11Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for ULK1 (132379196 - 132407712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for ULK1 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv990859CNV Deletion20482838
    esv2746906CNV Deletion23290073
    esv2274339CNV Deletion18987734
    nsv942CNV Insertion18451855
    nsv899707CNV Loss21882294
    dgv1517n71CNV Loss21882294
    nsv899711CNV Loss21882294
    nsv455804CNV Loss19166990
    nsv899710CNV Loss21882294
    nsv899712CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603168    OMIM disorders: --

    6 diseases for ULK1:    About MalaCards
    osteoarthritis    crohn's disease    alcoholism    esophagitis
    pancreatitis    neuronitis


    ULK1 for disorders           About GeneDecksing


    Export disorders for ULK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ULK1 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with ULK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. (PubMed id 9693035)1, 2, 3, 9 Kuroyanagi H.... Shirasawa T. (1998)
    2. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PubMed id 19287211)1, 2, 9 Mercer C.A.... Dennis P.B. (2009)
    3. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PubMed id 18936157)1, 2, 9 Chan E.Y....Tooze S.A. (2009)
    4. TBC1D14 regulates autophagosome formation via Rab11- a nd ULK1-positive recycling endosomes. (PubMed id 22613832)1, 2 Longatti A....Tooze S.A. (2012)
    5. ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. (PubMed id 21795849)1, 2 Jung C.H.... Kim D.H. (2011)
    6. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PubMed id 21460634)1, 2 Loffler A.S.... Stork B. (2011)
    7. Phosphorylation of ULK1 (hATG1) by AMP-activated prot ein kinase connects energy sensing to mitophagy. (PubMed id 21205641)1, 2 Egan D.F....Shaw R.J. (2011)
    8. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (PubMed id 19211835)1, 2 Hosokawa N....Mizushima N. (2009)
    9. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. (PubMed id 11146101)1, 2 Okazaki N.... Muramatsu M.-A. (2000)
    10. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8408 HGNC: 12558 AceView: ULK1 Ensembl:ENSG00000177169 euGenes: HUgn8408
    ECgene: ULK1 Kegg: 8408 H-InvDB: ULK1

    (According to HUGE)
    About This Section
    HUGE: KIAA0722

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ULK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ULK1 gene:
    Search GeneIP for patents involving ULK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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