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Aliases for ULBP3 Gene

Aliases for ULBP3 Gene

  • UL16 Binding Protein 3 2 3 5
  • Retinoic Acid Early Transcript 1N 3 4
  • ALCAN-Gamma 3 4
  • NKG2DL3 3 4
  • N2DL-3 3 4
  • RAET1N 3 4
  • UL16-Binding Protein 3 3
  • N2DL3 4

External Ids for ULBP3 Gene

Previous GeneCards Identifiers for ULBP3 Gene

  • GC06M149946
  • GC06M150281
  • GC06M150416
  • GC06M150477
  • GC06M147951

Summaries for ULBP3 Gene

Entrez Gene Summary for ULBP3 Gene

  • The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]

GeneCards Summary for ULBP3 Gene

ULBP3 (UL16 Binding Protein 3) is a Protein Coding gene. Among its related pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1E.

UniProtKB/Swiss-Prot for ULBP3 Gene

  • Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.

Gene Wiki entry for ULBP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULBP3 Gene

Genomics for ULBP3 Gene

Regulatory Elements for ULBP3 Gene

Promoters for ULBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ULBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ULBP3 Gene

Chromosome:
6
Start:
150,063,150 bp from pter
End:
150,069,213 bp from pter
Size:
6,064 bases
Orientation:
Minus strand

Genomic View for ULBP3 Gene

Genes around ULBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULBP3 Gene

Proteins for ULBP3 Gene

  • Protein details for ULBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM4-N2DL3_HUMAN
    Recommended name:
    NKG2D ligand 3
    Protein Accession:
    Q9BZM4
    Secondary Accessions:
    • Q5VY82
    • Q8IZX5
    • Q8TE75

    Protein attributes for ULBP3 Gene

    Size:
    244 amino acids
    Molecular mass:
    27949 Da
    Quaternary structure:
    • Does not bind to beta2-microglobulin. Interacts with human cytomegalovirus/HHV-5 protein UL142.
    Miscellaneous:
    • The region from chromosome 6q24.1-6q25.3 contains as many as 10 ULBP-related sequences, many of which are pseudogenes.
    • The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.

    Three dimensional structures from OCA and Proteopedia for ULBP3 Gene

neXtProt entry for ULBP3 Gene

Proteomics data for ULBP3 Gene at MOPED

Post-translational modifications for ULBP3 Gene

  • Glycosylation at Asn 37 and Thr 213
  • Modification sites at PhosphoSitePlus

Other Protein References for ULBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ULBP3 Gene

Domains & Families for ULBP3 Gene

Protein Domains for ULBP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZM4

UniProtKB/Swiss-Prot:

N2DL3_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with ULBP3: view

No data available for Gene Families for ULBP3 Gene

Function for ULBP3 Gene

Molecular function for ULBP3 Gene

UniProtKB/Swiss-Prot Function:
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.
genes like me logo Genes that share phenotypes with ULBP3: view

Animal Model Products

CRISPR Products

miRNA for ULBP3 Gene

miRTarBase miRNAs that target ULBP3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ULBP3 Gene

Localization for ULBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULBP3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULBP3 Gene COMPARTMENTS Subcellular localization image for ULBP3 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
cytoskeleton 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ULBP3 Gene

Pathways & Interactions for ULBP3 Gene

genes like me logo Genes that share pathways with ULBP3: view

Gene Ontology (GO) - Biological Process for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0042267 natural killer cell mediated cytotoxicity IDA 11239445
genes like me logo Genes that share ontologies with ULBP3: view

No data available for SIGNOR curated interactions for ULBP3 Gene

Drugs & Compounds for ULBP3 Gene

(1) Drugs for ULBP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ULBP3: view

Transcripts for ULBP3 Gene

mRNA/cDNA for ULBP3 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ULBP3 Gene

UL16 binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULBP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for ULBP3 Gene

GeneLoc Exon Structure for
ULBP3
ECgene alternative splicing isoforms for
ULBP3

Expression for ULBP3 Gene

mRNA expression in normal human tissues for ULBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULBP3 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for ULBP3 Gene

This gene is overexpressed in Serum (57.2) and Testis (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULBP3 Gene



SOURCE GeneReport for Unigene cluster for ULBP3 Gene Hs.326556

genes like me logo Genes that share expression patterns with ULBP3: view

Protein tissue co-expression partners for ULBP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ULBP3 Gene

Orthologs for ULBP3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ULBP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC101903261 35
  • 69.41 (n)
  • 52.2 (a)
-- 36
  • 48 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ULBP3 35
  • 98.09 (n)
  • 96.28 (a)
ULBP3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 31 (a)
OneToMany
Species with no ortholog for ULBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ULBP3 Gene

ENSEMBL:
Gene Tree for ULBP3 (if available)
TreeFam:
Gene Tree for ULBP3 (if available)

Paralogs for ULBP3 Gene

Paralogs for ULBP3 Gene

(9) SIMAP similar genes for ULBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ULBP3: view

Variants for ULBP3 Gene

Sequence variations from dbSNP and Humsavar for ULBP3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs553620 -- 150,062,974(-) CAGGC(A/G)CCCGC downstream-variant-500B
rs612770 -- 150,062,830(+) GGGCG(C/T)GGTGG downstream-variant-500B
rs669009 -- 150,066,166(-) TTTCC(A/G/T)TAGAC intron-variant
rs622317 -- 150,069,177(-) GGGAC(C/G)GGACG upstream-variant-2KB, utr-variant-5-prime
rs945193 -- 150,070,321(-) TTCTA(G/T)GCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ULBP3 Gene

Variant ID Type Subtype PubMed ID
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
esv2732878 CNV Deletion 23290073
esv7375 CNV Loss 19470904
esv2678333 CNV Deletion 23128226
nsv886767 CNV Gain 21882294
esv2664929 CNV Deletion 23128226

Variation tolerance for ULBP3 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULBP3 Gene

HapMap Linkage Disequilibrium report
ULBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULBP3 Gene

Disorders for ULBP3 Gene

Relevant External Links for ULBP3

Genetic Association Database (GAD)
ULBP3
Human Genome Epidemiology (HuGE) Navigator
ULBP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULBP3

No disorders were found for ULBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULBP3 Gene

Publications for ULBP3 Gene

  1. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PMID: 11827464) Radosavljevic M. … Bahram S. (Genomics 2002) 2 3 4 67
  2. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 23
  3. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 23
  4. [Expression of NKG2D ligands on dendritic cells at different development stages and its effect on cytotoxicity of NK cells]. (PMID: 18394338) Tu S.F. … Sun M. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008) 3 23
  5. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PMID: 11239445) Cosman D. … Chalupny N.J. (Immunity 2001) 2 3

Products for ULBP3 Gene

Sources for ULBP3 Gene

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