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Aliases for ULBP3 Gene

Aliases for ULBP3 Gene

  • UL16 Binding Protein 3 2 3
  • Retinoic Acid Early Transcript 1N 3 4
  • ALCAN-Gamma 3 4
  • NKG2DL3 3 4
  • N2DL-3 3 4
  • RAET1N 3 4
  • UL16-Binding Protein 3 3
  • NKG2D Ligand 3 3
  • N2DL3 4

External Ids for ULBP3 Gene

Summaries for ULBP3 Gene

GeneCards Summary for ULBP3 Gene

ULBP3 (UL16 Binding Protein 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1G.

UniProtKB/Swiss-Prot for ULBP3 Gene

  • Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.

Gene Wiki entry for ULBP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULBP3 Gene

Genomics for ULBP3 Gene

Genomic Location for ULBP3 Gene

Start:
150,062,723 bp from pter
End:
150,069,194 bp from pter
Size:
6,472 bases
Orientation:
Minus strand

Genomic View for ULBP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ULBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULBP3 Gene

Regulatory Elements for ULBP3 Gene

Proteins for ULBP3 Gene

  • Protein details for ULBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM4-N2DL3_HUMAN
    Recommended name:
    NKG2D ligand 3
    Protein Accession:
    Q9BZM4
    Secondary Accessions:
    • Q5VY82
    • Q8IZX5
    • Q8TE75

    Protein attributes for ULBP3 Gene

    Size:
    244 amino acids
    Molecular mass:
    27949 Da
    Quaternary structure:
    • Does not bind to beta2-microglobulin. Interacts with human cytomegalovirus/HHV-5 protein UL142.
    Miscellaneous:
    • The region from chromosome 6q24.1-6q25.3 contains as many as 10 ULBP-related sequences, many of which are pseudogenes
    • The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides

    Three dimensional structures from OCA and Proteopedia for ULBP3 Gene

neXtProt entry for ULBP3 Gene

Proteomics data for ULBP3 Gene at MOPED

Post-translational modifications for ULBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn37, Thr209, and Thr213

Other Protein References for ULBP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ULBP3 Gene

Domains for ULBP3 Gene

Protein Domains for ULBP3 Gene

UniProtKB/Swiss-Prot:

N2DL3_HUMAN
Family:
  • Belongs to the MHC class I family.:
    • Q9BZM4
genes like me logo Genes that share domains with ULBP3: view

No data available for Gene Families for ULBP3 Gene

Function for ULBP3 Gene

Molecular function for ULBP3 Gene

UniProtKB/Swiss-Prot Function: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.

Gene Ontology (GO) - Molecular Function for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042605 peptide antigen binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IDA 11239445
genes like me logo Genes that share ontologies with ULBP3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ULBP3 Gene

Localization for ULBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULBP3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULBP3 Gene COMPARTMENTS Subcellular localization image for ULBP3 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0046658 anchored component of plasma membrane IDA 11239445
genes like me logo Genes that share ontologies with ULBP3: view

Pathways for ULBP3 Gene

genes like me logo Genes that share pathways with ULBP3: view

Pathways by source for ULBP3 Gene

Gene Ontology (GO) - Biological Process for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IBA --
GO:0006955 immune response --
GO:0016032 viral process IEA --
GO:0019882 antigen processing and presentation --
GO:0030101 natural killer cell activation IDA 11239445
genes like me logo Genes that share ontologies with ULBP3: view

Compounds for ULBP3 Gene

(1) HMDB Compounds for ULBP3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with ULBP3: view

Transcripts for ULBP3 Gene

mRNA/cDNA for ULBP3 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ULBP3 Gene

UL16 binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ULBP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for ULBP3 Gene

GeneLoc Exon Structure for
ULBP3
ECgene alternative splicing isoforms for
ULBP3

Expression for ULBP3 Gene

mRNA expression in normal human tissues for ULBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULBP3 Gene

This gene is overexpressed in Testis (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ULBP3 Gene

SOURCE GeneReport for Unigene cluster for ULBP3 Gene Hs.326556

genes like me logo Genes that share expressions with ULBP3: view

Orthologs for ULBP3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ULBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULBP3 36
  • 98.09 (n)
  • 96.28 (a)
ULBP3 37
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 48 (a)
ManyToMany
LOC101903261 36
  • 69.41 (n)
  • 52.2 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 31 (a)
OneToMany
Species with no ortholog for ULBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ULBP3 Gene

ENSEMBL:
Gene Tree for ULBP3 (if available)
TreeFam:
Gene Tree for ULBP3 (if available)

Paralogs for ULBP3 Gene

Paralogs for ULBP3 Gene

Selected SIMAP similar genes for ULBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ULBP3: view

Variants for ULBP3 Gene

Sequence variations from dbSNP and Humsavar for ULBP3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs553620 -- 150,062,974(-) CAGGC(A/G)CCCGC downstream-variant-500B, utr-variant-3-prime
rs612770 -- 150,062,830(+) GGGCG(C/T)GGTGG downstream-variant-500B, utr-variant-3-prime
rs622317 -- 150,069,177(-) GGGAC(C/G)GGACG upstream-variant-2KB, utr-variant-5-prime
rs669009 -- 150,066,166(-) TTTCC(A/T)TAGAC intron-variant
rs912557 -- 150,064,841(-) ACAGC(A/G)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ULBP3 Gene

Variant ID Type Subtype PubMed ID
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
esv2732878 CNV Deletion 23290073
esv7375 CNV Loss 19470904
esv2678333 CNV Deletion 23128226
nsv886767 CNV Gain 21882294
esv2664929 CNV Deletion 23128226

Relevant External Links for ULBP3 Gene

HapMap Linkage Disequilibrium report
ULBP3

Disorders for ULBP3 Gene

(1) University of Copenhagen DISEASES for ULBP3 Gene

Relevant External Links for ULBP3

Genetic Association Database (GAD)
ULBP3
Human Genome Epidemiology (HuGE) Navigator
ULBP3
genes like me logo Genes that share disorders with ULBP3: view

No data available for UniProtKB/Swiss-Prot for ULBP3 Gene

Publications for ULBP3 Gene

  1. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 23 49
  2. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 23 49
  3. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PMID: 11239445) Cosman D. … Chalupny N.J. (Immunity 2001) 2 3 4
  4. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PMID: 11827464) Radosavljevic M. … Bahram S. (Genomics 2002) 2 3 4
  5. Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus. (PMID: 20530255) Bennett N.J. … Wills M.R. (J. Immunol. 2010) 3 4

Products for ULBP3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ULBP3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ULBP3
    • Block miRNA regulation of ULBP3 using miScript Target Protectors

    Sources for ULBP3 Gene

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