Aliases for ULBP3 Gene
External Ids for ULBP3 Gene
Previous GeneCards Identifiers for ULBP3 Gene
GeneCards Summary for ULBP3 Gene
ULBP3 (UL16 Binding Protein 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1G.
UniProtKB/Swiss-Prot for ULBP3 Gene
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.