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Aliases for ULBP3 Gene

Aliases for ULBP3 Gene

  • UL16 Binding Protein 3 2 3 5
  • Retinoic Acid Early Transcript 1N 3 4
  • ALCAN-Gamma 3 4
  • NKG2DL3 3 4
  • N2DL-3 3 4
  • RAET1N 3 4
  • NKG2D Ligand 3 3
  • N2DL3 4

External Ids for ULBP3 Gene

Previous GeneCards Identifiers for ULBP3 Gene

  • GC06M149946
  • GC06M150281
  • GC06M150416
  • GC06M150477
  • GC06M147951

Summaries for ULBP3 Gene

Entrez Gene Summary for ULBP3 Gene

  • The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]

GeneCards Summary for ULBP3 Gene

ULBP3 (UL16 Binding Protein 3) is a Protein Coding gene. Diseases associated with ULBP3 include Alopecia Areata. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP2.

UniProtKB/Swiss-Prot for ULBP3 Gene

  • Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.

Gene Wiki entry for ULBP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULBP3 Gene

Genomics for ULBP3 Gene

Regulatory Elements for ULBP3 Gene

Enhancers for ULBP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F150071 1.1 Ensembl ENCODE 11.4 -3.1 -3088 1.0 HDGF PKNOX1 KLF17 GLIS2 ZNF366 SCRT2 RCOR1 KLF7 FOS KLF13 ULBP3 PPP1R14C IYD
GH06F150068 0.9 ENCODE 10.8 +0.2 175 1.7 TBP PKNOX1 ZNF76 SIN3A KLF17 BRCA1 RAD21 YY1 ZNF121 GLIS2 ULBP3 ARL4AP5 LOC729496 PIR32224
GH06F150072 1.1 Ensembl ENCODE 0.8 -2.1 -2088 0.6 CTCF ZNF384 ZNF2 RAD21 ZEB1 ZNF324 ZNF366 ZNF143 SMC3 PRDM10 PPP1R14C IYD ULBP3
GH06F150080 0.7 ENCODE 0.4 -11.6 -11627 0.2 CTCF CBX3 ZNF2 RAD21 ZEB1 ZNF143 SMC3 NFE2 ZNF654 HCFC1 RNU4-7P PPP1R14C ENSG00000238594 IYD ULBP3
GH06F150079 0.7 ENCODE 0.4 -10.6 -10567 0.0 CTCF HCFC1 ZNF76 SIX5 ZIC2 OSR2 ZBTB48 GLIS1 ZNF341 ZNF143 PPP1R14C GINM1 ULBP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ULBP3 on UCSC Golden Path with GeneCards custom track

Promoters for ULBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001230588 113 1401 TBP PKNOX1 ZNF76 SIN3A KLF17 FEZF1 BRCA1 RAD21 YY1 ZNF121

Genomic Location for ULBP3 Gene

Chromosome:
6
Start:
150,063,150 bp from pter
End:
150,069,213 bp from pter
Size:
6,064 bases
Orientation:
Minus strand

Genomic View for ULBP3 Gene

Genes around ULBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULBP3 Gene

Proteins for ULBP3 Gene

  • Protein details for ULBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM4-N2DL3_HUMAN
    Recommended name:
    NKG2D ligand 3
    Protein Accession:
    Q9BZM4
    Secondary Accessions:
    • Q5VY82
    • Q8IZX5
    • Q8TE75

    Protein attributes for ULBP3 Gene

    Size:
    244 amino acids
    Molecular mass:
    27949 Da
    Quaternary structure:
    • Does not bind to beta2-microglobulin. Interacts with human cytomegalovirus/HHV-5 protein UL142.
    Miscellaneous:
    • The region from chromosome 6q24.1-6q25.3 contains as many as 10 ULBP-related sequences, many of which are pseudogenes.
    • The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.

    Three dimensional structures from OCA and Proteopedia for ULBP3 Gene

neXtProt entry for ULBP3 Gene

Post-translational modifications for ULBP3 Gene

  • Glycosylation at Asn 37 and Thr 213
  • Modification sites at PhosphoSitePlus

Other Protein References for ULBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ULBP3

No data available for DME Specific Peptides for ULBP3 Gene

Domains & Families for ULBP3 Gene

Protein Domains for ULBP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZM4

UniProtKB/Swiss-Prot:

N2DL3_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with ULBP3: view

No data available for Gene Families for ULBP3 Gene

Function for ULBP3 Gene

Molecular function for ULBP3 Gene

UniProtKB/Swiss-Prot Function:
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.

Gene Ontology (GO) - Molecular Function for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IDA 11239445
genes like me logo Genes that share ontologies with ULBP3: view
genes like me logo Genes that share phenotypes with ULBP3: view

Animal Model Products

miRNA for ULBP3 Gene

miRTarBase miRNAs that target ULBP3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ULBP3 Gene

Localization for ULBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULBP3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ULBP3 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0046658 anchored component of plasma membrane IDA 11239445
genes like me logo Genes that share ontologies with ULBP3: view

Pathways & Interactions for ULBP3 Gene

genes like me logo Genes that share pathways with ULBP3: view

Interacting Proteins for ULBP3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356308%0d%0a9606.ENSP00000240618%0d%0a9606.ENSP00000349709%0d%0a9606.ENSP00000229708%0d%0a9606.ENSP00000246551%0d%0a9606.ENSP00000455951%0d%0a
Selected Interacting proteins: ENSP00000356308 Q9BZM4-N2DL3_HUMAN for ULBP3 Gene via STRING IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
KLRK1

Gene Ontology (GO) - Biological Process for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0019882 antigen processing and presentation IBA --
GO:0030101 natural killer cell activation IDA 11239445
GO:0042267 natural killer cell mediated cytotoxicity IDA 11239445
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with ULBP3: view

No data available for SIGNOR curated interactions for ULBP3 Gene

Drugs & Compounds for ULBP3 Gene

(1) Drugs for ULBP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ULBP3: view

Transcripts for ULBP3 Gene

mRNA/cDNA for ULBP3 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ULBP3 Gene

UL16 binding protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULBP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for ULBP3 Gene

GeneLoc Exon Structure for
ULBP3
ECgene alternative splicing isoforms for
ULBP3

Expression for ULBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ULBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULBP3 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for ULBP3 Gene

This gene is overexpressed in Serum (57.2) and Testis (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULBP3 Gene



Protein tissue co-expression partners for ULBP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ULBP3 Gene:

ULBP3

SOURCE GeneReport for Unigene cluster for ULBP3 Gene:

Hs.326556
genes like me logo Genes that share expression patterns with ULBP3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ULBP3 Gene

Orthologs for ULBP3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ULBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULBP3 34 35
  • 98.09 (n)
cow
(Bos Taurus)
Mammalia LOC101903261 34
  • 69.41 (n)
-- 35
  • 48 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 31 (a)
OneToMany
Species where no ortholog for ULBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ULBP3 Gene

ENSEMBL:
Gene Tree for ULBP3 (if available)
TreeFam:
Gene Tree for ULBP3 (if available)

Paralogs for ULBP3 Gene

Paralogs for ULBP3 Gene

(9) SIMAP similar genes for ULBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ULBP3: view

Variants for ULBP3 Gene

Sequence variations from dbSNP and Humsavar for ULBP3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10588767 -- 150,061,011(+) AAAAA(-/AA)GTAAG downstream-variant-500B
rs1077426 -- 150,064,955(+) TGTGG(C/T)GGAAG intron-variant
rs111410930 -- 150,064,942(+) CCCAC(C/T)CTCCT intron-variant
rs111496180 -- 150,063,186(+) TGAGA(C/T)GTTGA utr-variant-3-prime
rs111674412 -- 150,064,411(+) TCAAG(A/G)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ULBP3 Gene

Variant ID Type Subtype PubMed ID
esv2664929 CNV deletion 23128226
esv2678333 CNV deletion 23128226
esv2732878 CNV deletion 23290073
esv3611222 CNV loss 21293372
esv3890963 CNV loss 25118596
esv7375 CNV loss 19470904
nsv1026236 CNV loss 25217958
nsv517022 CNV gain+loss 19592680

Variation tolerance for ULBP3 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ULBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULBP3 Gene

Disorders for ULBP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ULBP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alopecia areata
  • alopecia
- elite association - COSMIC cancer census association via MalaCards
Search ULBP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ULBP3

Genetic Association Database (GAD)
ULBP3
Human Genome Epidemiology (HuGE) Navigator
ULBP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULBP3
genes like me logo Genes that share disorders with ULBP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ULBP3 Gene

Publications for ULBP3 Gene

  1. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 22 46 64
  2. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 22 46 64
  3. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PMID: 11827464) Radosavljevic M. … Bahram S. (Genomics 2002) 2 3 4 64
  4. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PMID: 11239445) Cosman D. … Chalupny N.J. (Immunity 2001) 2 3 4 64
  5. Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus. (PMID: 20530255) Bennett N.J. … Wills M.R. (J. Immunol. 2010) 3 4 64

Products for ULBP3 Gene

Sources for ULBP3 Gene

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