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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ULBP3 Gene

protein-coding   GIFtS: 55
GCID: GC06M150477

UL16 binding protein 3
 Explore 12 diseases affiliated with
ULBP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ULBP3    

Aliases
for ULBP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UL16 Binding Protein 31 2     NKG2DL32 3
RAET1N1 2 3     NKG2D Ligand 32
Retinoic Acid Early Transcript 1N2 3     UL16-Binding Protein 32
ALCAN-Gamma1     N2DL33
N2DL-32 3     

External Ids:    HGNC: 148951   Entrez Gene: 794652   Ensembl: ENSG000001310197   OMIM: 6056995   UniProtKB: Q9BZM43   

Export aliases for ULBP3 gene to outside databases

Previous GC identifers: GC06M149946 GC06M150281 GC06M150416 GC06M147951


Summaries
for ULBP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: N2DL3_HUMAN, Q9BZM4
Function: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling
pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to
NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction
pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does
ULBP2 or ULBP1

Gene Wiki entry for ULBP3


Genomic Views
for ULBP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ULBP3 gene promoter:
         USF1   USF2   FOXD3   USF-1:USF-2   Evi-1   MEF-2A   USF-1   Sox9   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ULBP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ULBP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25

ULBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULBP3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M150477:  view genomic region     (about GC identifiers)

Start:
 150,384,286 bp from pter      End:
 150,390,231 bp from pter
Size:
 5,946 bases      Orientation:
 minus strand

Proteins
for ULBP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: N2DL3_HUMAN, Q9BZM4 (See protein sequence)
Recommended Name: NKG2D ligand 3 precursor  
Size: 244 amino acids; 27949 Da
Subunit: Does not bind to beta2-microglobulin. Interacts with human cytomegalovirus/HHV-5 protein UL142
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Miscellaneous: The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the
alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides
Miscellaneous: The region from chromosome 6q24.1-6q25.3 contains as many as 10 ULBP-related sequences, many of which
are pseudogenes
1 PDB 3D structure from and Proteopedia for ULBP3:
1KCG (3D)    
Secondary accessions: Q5VY82 Q8IZX5 Q8TE75

Explore the universe of human proteins at neXtProt for ULBP3: NX_Q9BZM4

ULBP3 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_078794.1  
ENSEMBL proteins: 
 ENSP00000356308   ENSP00000403562  
Reactome Protein details: Q9BZM4
Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for ULBP3 (ULBP-3)
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OriGene Custom Protein Services for ULBP3 
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Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for ULBP3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016020membrane NAS--
GO:0031225anchored to membrane IEA--
GO:0042612MHC class I protein complex IEA--


ULBP3 for ontologies           About GeneDecksing



ULBP3 Antibody Products: 
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Novus Biologicals ULBP3 Antibody
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Uscn Antibodies for ULBP3
Search ThermoFisher Antibodies for ULBP3

Assay Products for ULBP3: 
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GenScript Custom Assay Services for ULBP3
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Uscn ELISAs and CLIAs for ULBP3

Protein Domains /
Families
for ULBP3 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
ULBP3 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR011161 MHC_I-like_Ag-recog
 IPR011162 MHC_I/II-like_Ag-recog
 IPR001039 MHC_I_a_a1/a2

Graphical View of Domain Structure for InterPro Entry Q9BZM4

ProtoNet protein and cluster: Q9BZM4

1 Blocks protein family: IPB001039 MHC class I signature

UniProtKB/Swiss-Prot: N2DL3_HUMAN, Q9BZM4
Similarity: Belongs to the MHC class I family


Function
for ULBP3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: N2DL3_HUMAN, Q9BZM4
Function: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling
pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to
NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction
pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does
ULBP2 or ULBP1

miRNA
Products:    		Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ULBP3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ULBP3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULBP3
OriGene shRNA RFP: ULBP3
OriGene siRNA: ULBP3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULBP3

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for ULBP3

Clone
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GenScript: all cDNA clones in your preferred vector: ULBP3 (NM_024518)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULBP3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULBP3 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for ULBP3
Search LifeMap BioReagents cell lines for ULBP3

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULBP3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0032393MHC class I receptor activity NAS11239445


ULBP3 for ontologies           About GeneDecksing



Pathways & Interactions
for ULBP3 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Immune System
Immune System1.00
Adaptive Immune System0.59
2Natural killer cell mediated cytotoxicity
Natural killer cell mediated cytotoxicity1.00
3Cleavage of Alpha-1-Microglobulin
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

Pathway sources
See GeneCards unified pathways
Show all pathways


3        Reactome Pathways for ULBP3
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Immune System


1         Kegg Pathway  (Kegg details for ULBP3):
    Natural killer cell mediated cytotoxicity


ULBP3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ULBP3

1 Interacting protein for ULBP3 (Q9BZM43) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
KLRK1P267183I2D: score=3 
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response IEA--
GO:0019048virus-host interaction IEA--
GO:0019882antigen processing and presentation IEA--
GO:0030101natural killer cell activation NAS11239445
GO:0044419interspecies interaction between organisms ----


ULBP3 for ontologies           About GeneDecksing



Drugs & Compounds
for ULBP3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ULBP3

1 HMDB Compound for ULBP3    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
Search CenterWatch for drugs/clinical trials and news about ULBP3 / N2DL3 

Transcripts
for ULBP3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for ULBP3 gene: 
NM_024518.1  

Unigene Cluster for ULBP3:

UL16 binding protein 3
Hs.326556  [show with all ESTs]
Unigene Representative Sequence: AK297815
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000367339(uc011eej.1 uc003qns.3 uc011eek.1) ENST00000438272


miRNA
Products:     		Browse 3'-UTR reporter clones for miRNA target validation
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ULBP3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ULBP3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULBP3
OriGene shRNA RFP: ULBP3
OriGene siRNA: ULBP3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULBP3
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULBP3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULBP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: ULBP3 (NM_024518)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULBP3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULBP3 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ULBP3
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ULBP3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULBP3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULBP3

Additional cDNA sequence: 

AB052908.1 AF304379.1 AF346596.1 AK297815.1 AK302076.1 AK315275.1 AY027538.1 BC098127.1 

2 DOTS entries:

DT.75195179  DT.428295 

8 AceView cDNA sequences:

AY027538 NM_024518 BP364885 AB052908 AF304379 AF346596 AI091180 BF844817 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ULBP3    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:              -                           
SP2:                                          


ECgene alternative splicing isoforms for ULBP3

Expression
for ULBP3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ULBP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGCAAAT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

ULBP3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
OvaryAntral FollicleCumulus CellsOvary
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See ULBP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ULBP3

SOURCE GeneReport for Unigene cluster: Hs.326556
    SABiosciences Custom PCR Arrays for ULBP3
Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ULBP3
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ULBP3
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULBP3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULBP3
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULBP3

Orthologs
for ULBP3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for ULBP3 (if available)
TreeFam Gene Tree for ULBP3 (if available) 

Paralogs
for ULBP3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ULBP3 gene
ULBP12  RAET1G2  RAET1E2  RAET1L2  ULBP22  
9 SIMAP similar genes for ULBP3 using alignment to 1 protein entry:     N2DL3_HUMAN:
RAET1H    RAET1L    ULBP1    RAET1G    ULBP2    RAET-1E
RAET1E    HLA-B    HLA-A

ULBP3 for paralogs           About GeneDecksing



Genomic Variants
for ULBP3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/175 NCBI SNPs in ULBP3 are shown (see all 175)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 6 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1831325901,2
--150385258(+) CCCCTC/TGTCCT 1 -- ds50010--------
rs1869247241,2
--150385259(+) CCCTCA/GTCCTG 1 -- ds50010--------
rs1172921541,2
--150385297(+) GCCTCC/TTCCAG 1 -- ds50011Minor allele frequency- T:0.01NA 120
rs1509953231,2
--150385431(+) AACCTA/GCTGTG 1 -- ds50010--------
rs20102591,2
C,F,O,A,H,,--150385475(-) GGGCCG/AGTTGA 1 -- ds500124Minor allele frequency- A:0.31NS EA NA WA 4032
rs126620671,2
C,F,H,--150385476(+) CAACCG/AGCCCT 1 -- ds50018Minor allele frequency- A:0.10NS WA NA CSA EA 484
rs1408303851,2
--150385577(+) CAGGCA/GACACC 1 -- ds50010--------
rs759312841,2
C,F,--150385618(+) GAGAAG/AGTCCC 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs48698151,2
C,F,A,--150385670(+) TTCCTC/TCCACC 1 -- ds5001 trp35Minor allele frequency- T:0.20WA NA CSA 243
rs2017384151,2
--150385714(+) TGCCCA/TCAGTA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for ULBP3 (150384286 - 150390231 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ULBP3
     1 CNV: 62586

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ULBP3
DNA2.0 Custom Variant and Variant Library Synthesis for ULBP3

Disorders / Diseases
for ULBP3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
ULBP3 for disorders           About GeneDecksing

OMIM gene information: 605699    OMIM disorders: --

12 diseases for ULBP3:    About MalaCards
alopecia areata    chronic lymphocytic leukemia    acute myeloid leukemia    alopecia
lymphocytic leukemia    myeloid leukemia    malignant glioma    hepatitis b
leukemia    nasopharyngitis    hepatitis    carcinoma

1 disease from the University of Copenhagen DISEASES database for ULBP3:
Alopecia areata
Human Genome Epidemiology (HuGE) Navigator: ULBP3 (5 documents)

Export disorders for ULBP3 gene to outside databases

Publications
for ULBP3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ULBP3 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with ULBP3)		    Utopia: connect your pdf to the dynamic
world of online information

  1. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PubMed id 11827464)1, 2, 3 Radosavljevic M.... Bahram S. (2002)
  2. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PubMed id 11239445)1, 2, 3 Cosman D.... Chalupny N.J. (2001)
  3. Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus. (PubMed id 20530255)1, 2 Bennett N.J....Wills M.R. (2010)
  4. NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. (PubMed id 12753652)1, 2 Cerwenka A. and Lanier L.L. (2003)
  5. Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. (PubMed id 11754823)1, 2 Radaev S.... Sun P.D. (2001)
  6. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. (PubMed id 11491531)1, 2 Steinle A....Spies T. (2001)
  7. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP ge nes in northeastern Thais. (PubMed id 19688209)1, 9 Romphruk A.V....Leelayuwat C. (2009)
  8. [Expression of NKG2D ligands on dendritic cells at different development stages and its effect on cytotoxicity of NK cells.] (PubMed id 18394338)1, 9 Tu S.F....Sun M. (2008)
  9. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evi dence of diversity between human populations. (PubMed id 20219610)1, 9 Antoun A....Briggs D.C. (2010)
  10. The antiviral factor APOBEC3G enhances the recognitio n of HIV-infected primary T cells by natural killer cells. (PubMed id 21874023)1 Norman J.M....Collins K.L. (2011)

External Searches for ULBP3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
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Genome Databases showing ULBP3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 79465 HGNC: 14895 AceView: ULBP3 Ensembl:ENSG00000131019 euGenes: HUgn79465
ECgene: ULBP3 Kegg: 79465 H-InvDB: ULBP3

Other Databases showing ULBP3 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing ULBP3 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ULBP3 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for ULBP3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ULBP3 gene:
Search GeneIP for patents involving ULBP3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for ULBP3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for ULBP3 (ULBP-3)   Browse Cell Culture Products  
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 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
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 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for ULBP3 (ULBP-3)  
 Browse OriGene Antibodies   OriGene shRNA RFP for ULBP3  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULBP3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ULBP3  
 Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for ULBP3   Browse 3'-UTR reporter clones for miRNA target validation  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULBP3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ULBP3  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for ULBP3   OriGene Custom Protein Services for ULBP3  
 OriGene Custom Immunoassay Development  

 		 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ULBP3
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ULBP3
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULBP3
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULBP3
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULBP3
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULBP3
 GenScript Custom Purified and Recombinant Proteins Services for ULBP3 GenScript cDNA clones with any tag delivered in your preferred vector for ULBP3
 GenScript Custom Assay Services for ULBP3 GenScript Custom Superior Antibodies Services for ULBP3
 GenScript Custom overexpressing Cell Line Services for ULBP3 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in ULBP3 promoter
 Search Chromatin IP Primers for ULBP3
 RT2 qPCR Primer Assay in human, mouse / rat ULBP3
 GNC Network for ULBP3
 SABiosciences Custom PCR Arrays for ULBP3
 Search Tocris compounds for ULBP3
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 ULBP3 antibodies
 Search for Antibodies for ULBP3 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for ULBP3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 ULBP3 Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for ULBP3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULBP3
 Browse SwitchGear 3'UTR luciferase reporter plasmids for ULBP3
 SwitchGear Promoter luciferase reporter plasmids for ULBP3
 Search ThermoFisher Antibodies for ULBP3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULBP3
       
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