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Aliases for ULBP2 Gene

Aliases for ULBP2 Gene

  • UL16 Binding Protein 2 2 3 5
  • Retinoic Acid Early Transcript 1H 3 4
  • ALCAN-Alpha 3 4
  • NKG2DL2 3 4
  • RAET1H 3 4
  • N2DL2 3 4
  • UL16-Binding Protein 2 4
  • N2DL-2 4

External Ids for ULBP2 Gene

Previous GeneCards Identifiers for ULBP2 Gene

  • GC06P149824
  • GC06P150158
  • GC06P150294
  • GC06P150355
  • GC06P150304
  • GC06P150263
  • GC06P147828
  • GC06P149935

Summaries for ULBP2 Gene

Entrez Gene Summary for ULBP2 Gene

  • This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

GeneCards Summary for ULBP2 Gene

ULBP2 (UL16 Binding Protein 2) is a Protein Coding gene. Among its related pathways are p53 Pathway (RnD) and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP3.

UniProtKB/Swiss-Prot for ULBP2 Gene

  • Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Gene Wiki entry for ULBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULBP2 Gene

Genomics for ULBP2 Gene

Regulatory Elements for ULBP2 Gene

Promoters for ULBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ULBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ULBP2 Gene

Chromosome:
6
Start:
149,941,938 bp from pter
End:
149,949,235 bp from pter
Size:
7,298 bases
Orientation:
Plus strand

Genomic View for ULBP2 Gene

Genes around ULBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULBP2 Gene

Proteins for ULBP2 Gene

  • Protein details for ULBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM5-N2DL2_HUMAN
    Recommended name:
    NKG2D ligand 2
    Protein Accession:
    Q9BZM5
    Secondary Accessions:
    • Q5VUN4

    Protein attributes for ULBP2 Gene

    Size:
    246 amino acids
    Molecular mass:
    27368 Da
    Quaternary structure:
    • Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.
    Miscellaneous:
    • The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.

neXtProt entry for ULBP2 Gene

Proteomics data for ULBP2 Gene at MOPED

Post-translational modifications for ULBP2 Gene

  • Glycosylation at Asn 68 and Asn 82
  • Modification sites at PhosphoSitePlus

Other Protein References for ULBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ULBP2 Gene

Domains & Families for ULBP2 Gene

Protein Domains for ULBP2 Gene

Suggested Antigen Peptide Sequences for ULBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZM5

UniProtKB/Swiss-Prot:

N2DL2_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with ULBP2: view

No data available for Gene Families for ULBP2 Gene

Function for ULBP2 Gene

Molecular function for ULBP2 Gene

UniProtKB/Swiss-Prot Function:
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Phenotypes for ULBP2 Gene

genes like me logo Genes that share phenotypes with ULBP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ULBP2 Gene

Localization for ULBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULBP2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULBP2 Gene COMPARTMENTS Subcellular localization image for ULBP2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ULBP2 Gene

Pathways & Interactions for ULBP2 Gene

genes like me logo Genes that share pathways with ULBP2: view

Pathways by source for ULBP2 Gene

Interacting Proteins for ULBP2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356320%0d%0a9606.ENSP00000240618%0d%0a9606.ENSP00000359848%0d%0a9606.ENSP00000257290%0d%0a
Selected Interacting proteins: Q9BZM5-N2DL2_HUMAN ENSP00000356320 for ULBP2 Gene via I2D STRING

SIGNOR curated interactions for ULBP2 Gene

Activates:

Gene Ontology (GO) - Biological Process for ULBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042267 natural killer cell mediated cytotoxicity IDA 11239445
genes like me logo Genes that share ontologies with ULBP2: view

Drugs & Compounds for ULBP2 Gene

(1) Drugs for ULBP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ULBP2: view

Transcripts for ULBP2 Gene

mRNA/cDNA for ULBP2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ULBP2 Gene

UL16 binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULBP2 Gene

No ASD Table

Relevant External Links for ULBP2 Gene

GeneLoc Exon Structure for
ULBP2
ECgene alternative splicing isoforms for
ULBP2

Expression for ULBP2 Gene

mRNA expression in normal human tissues for ULBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULBP2 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.6).

Protein differential expression in normal tissues from HIPED for ULBP2 Gene

This gene is overexpressed in Amniocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ULBP2 Gene



SOURCE GeneReport for Unigene cluster for ULBP2 Gene Hs.656778

mRNA Expression by UniProt/SwissProt for ULBP2 Gene

Q9BZM5-N2DL2_HUMAN
Tissue specificity: Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
genes like me logo Genes that share expression patterns with ULBP2: view

Protein tissue co-expression partners for ULBP2 Gene

Primer Products

In Situ Assay Products

Orthologs for ULBP2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ULBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULBP2 35
  • 96.88 (n)
  • 94.31 (a)
-- 36
  • 93 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia ULBP3 36
  • 34 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 32 (a)
OneToMany
Species with no ortholog for ULBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ULBP2 Gene

ENSEMBL:
Gene Tree for ULBP2 (if available)
TreeFam:
Gene Tree for ULBP2 (if available)

Paralogs for ULBP2 Gene

Paralogs for ULBP2 Gene

(9) SIMAP similar genes for ULBP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ULBP2: view

Variants for ULBP2 Gene

Sequence variations from dbSNP and Humsavar for ULBP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1128766 -- 149,949,110(+) GGATT(A/C)TTTCC utr-variant-3-prime
rs1555697 -- 149,945,442(-) CTGAC(A/G/T)GGTGT reference, synonymous-codon
rs2050385 -- 149,947,148(+) GGGTG(A/T)GTCTT intron-variant
rs2282235 -- 149,946,391(+) CAGGC(A/C)AGGAT reference, synonymous-codon
rs3798765 -- 149,947,435(+) GGAGA(A/G)TCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ULBP2 Gene

Variant ID Type Subtype PubMed ID
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
nsv886765 CNV Gain 21882294
esv2732866 CNV Deletion 23290073

Variation tolerance for ULBP2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULBP2 Gene

HapMap Linkage Disequilibrium report
ULBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULBP2 Gene

Disorders for ULBP2 Gene

Relevant External Links for ULBP2

Genetic Association Database (GAD)
ULBP2
Human Genome Epidemiology (HuGE) Navigator
ULBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULBP2

No disorders were found for ULBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULBP2 Gene

Publications for ULBP2 Gene

  1. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PMID: 11239445) Cosman D. … Chalupny N.J. (Immunity 2001) 2 3 4 67
  2. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 23
  3. Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells. (PMID: 19089914) Schwinn N. … Paschen A. (Int. J. Cancer 2009) 3 23
  4. Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain. (PMID: 19424970) Wittenbrink M. … Steinle A. (Eur. J. Immunol. 2009) 3 23
  5. Herpes simplex virus infection downmodulates NKG2D ligand expression. (PMID: 19508374) Schepis D. … Berg L. (Scand. J. Immunol. 2009) 3 23

Products for ULBP2 Gene

Sources for ULBP2 Gene

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