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Aliases for ULBP2 Gene

Aliases for ULBP2 Gene

  • UL16 Binding Protein 2 2 3
  • Retinoic Acid Early Transcript 1H 3 4
  • ALCAN-Alpha 3 4
  • NKG2DL2 3 4
  • RAET1H 3 4
  • N2DL2 3 4
  • UL16-Binding Protein 2 4
  • NKG2D Ligand 2 3
  • N2DL-2 4

External Ids for ULBP2 Gene

Summaries for ULBP2 Gene

GeneCards Summary for ULBP2 Gene

ULBP2 (UL16 Binding Protein 2) is a Protein Coding gene. Diseases associated with ULBP2 include chronic lymphocytic leukemia. Among its related pathways are Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP3.

UniProtKB/Swiss-Prot for ULBP2 Gene

  • Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Gene Wiki entry for ULBP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULBP2 Gene

Genomics for ULBP2 Gene

Genomic Location for ULBP2 Gene

Start:
149,934,765 bp from pter
End:
149,949,235 bp from pter
Size:
14,471 bases
Orientation:
Plus strand

Genomic View for ULBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ULBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULBP2 Gene

Regulatory Elements for ULBP2 Gene

Proteins for ULBP2 Gene

  • Protein details for ULBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM5-N2DL2_HUMAN
    Recommended name:
    NKG2D ligand 2
    Protein Accession:
    Q9BZM5
    Secondary Accessions:
    • Q5VUN4

    Protein attributes for ULBP2 Gene

    Size:
    246 amino acids
    Molecular mass:
    27368 Da
    Quaternary structure:
    • Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.
    Miscellaneous:
    • The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides

neXtProt entry for ULBP2 Gene

Proteomics data for ULBP2 Gene at MOPED

Post-translational modifications for ULBP2 Gene

Other Protein References for ULBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ULBP2 Gene

Domains for ULBP2 Gene

Protein Domains for ULBP2 Gene

UniProtKB/Swiss-Prot:

N2DL2_HUMAN
Family:
  • Belongs to the MHC class I family.:
    • Q9BZM5
genes like me logo Genes that share domains with ULBP2: view

No data available for Gene Families for ULBP2 Gene

Function for ULBP2 Gene

Molecular function for ULBP2 Gene

UniProtKB/Swiss-Prot Function: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Gene Ontology (GO) - Molecular Function for ULBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042605 peptide antigen binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IDA 11239445
genes like me logo Genes that share ontologies with ULBP2: view

Phenotypes for ULBP2 Gene

GenomeRNAi human phenotypes for ULBP2:
genes like me logo Genes that share phenotypes with ULBP2: view

miRNA for ULBP2 Gene

miRTarBase miRNAs that target ULBP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ULBP2 Gene

Localization for ULBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULBP2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ULBP2 Gene COMPARTMENTS Subcellular localization image for ULBP2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ULBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18676862
GO:0009986 cell surface IDA 18676862
GO:0046658 anchored component of plasma membrane IDA 11239445
genes like me logo Genes that share ontologies with ULBP2: view

Pathways for ULBP2 Gene

genes like me logo Genes that share pathways with ULBP2: view

Pathways by source for ULBP2 Gene

1 KEGG pathway for ULBP2 Gene

Interacting Proteins for ULBP2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356320%0d%0a9606.ENSP00000240618%0d%0a9606.ENSP00000359848%0d%0a9606.ENSP00000257290%0d%0a
Selected Interacting proteins: ENSP00000356320 Q9BZM5-N2DL2_HUMAN for ULBP2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ULBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IBA --
GO:0006955 immune response --
GO:0019882 antigen processing and presentation --
GO:0030101 natural killer cell activation IDA 11239445
GO:0042267 natural killer cell mediated cytotoxicity IDA 11239445
genes like me logo Genes that share ontologies with ULBP2: view

Compounds for ULBP2 Gene

(1) HMDB Compounds for ULBP2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with ULBP2: view

Transcripts for ULBP2 Gene

mRNA/cDNA for ULBP2 Gene

Unigene Clusters for ULBP2 Gene

UL16 binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ULBP2 Gene

No ASD Table

Relevant External Links for ULBP2 Gene

GeneLoc Exon Structure for
ULBP2
ECgene alternative splicing isoforms for
ULBP2

Expression for ULBP2 Gene

mRNA expression in normal human tissues for ULBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULBP2 Gene

This gene is overexpressed in Esophagus - Mucosa (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ULBP2 Gene

SOURCE GeneReport for Unigene cluster for ULBP2 Gene Hs.656778

mRNA Expression by UniProt/SwissProt for ULBP2 Gene

Q9BZM5-N2DL2_HUMAN
Tissue specificity: Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
genes like me logo Genes that share expressions with ULBP2: view

Orthologs for ULBP2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ULBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 93 (a)
ManyToMany
-- 37
  • 91 (a)
ManyToMany
ULBP2 36
  • 96.88 (n)
  • 94.31 (a)
cow
(Bos Taurus)
Mammalia ULBP3 37
  • 34 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 32 (a)
OneToMany
Species with no ortholog for ULBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ULBP2 Gene

ENSEMBL:
Gene Tree for ULBP2 (if available)
TreeFam:
Gene Tree for ULBP2 (if available)

Paralogs for ULBP2 Gene

Paralogs for ULBP2 Gene

Selected SIMAP similar genes for ULBP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ULBP2: view

Variants for ULBP2 Gene

Sequence variations from dbSNP and Humsavar for ULBP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1128766 -- 149,949,110(+) GGATT(A/C)TTTCC utr-variant-3-prime
rs2050385 -- 149,947,148(+) GGGTG(A/T)GTCTT intron-variant
rs2282235 -- 149,946,391(+) CAGGC(A/C)AGGAT reference, synonymous-codon
rs3798765 -- 149,947,435(+) GGAGA(A/G)TCCTT utr-variant-3-prime
rs4133316 -- 149,941,860(-) TGTCC(C/T)AACCC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ULBP2 Gene

Variant ID Type Subtype PubMed ID
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
nsv886765 CNV Gain 21882294
esv2732866 CNV Deletion 23290073

Relevant External Links for ULBP2 Gene

HapMap Linkage Disequilibrium report
ULBP2

Disorders for ULBP2 Gene

(1) Novoseek inferred disease relationships for ULBP2 Gene

Disease -log(P) Hits PubMed IDs
tumors 15.4 4

Relevant External Links for ULBP2

Genetic Association Database (GAD)
ULBP2
Human Genome Epidemiology (HuGE) Navigator
ULBP2
genes like me logo Genes that share disorders with ULBP2: view

No data available for UniProtKB/Swiss-Prot for ULBP2 Gene

Publications for ULBP2 Gene

  1. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 23 49
  2. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 23 49
  3. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PMID: 11239445) Cosman D. … Chalupny N.J. (Immunity 2001) 2 3 4
  4. A novel secreted tumor antigen with a glycosylphosphatidylinositol- anchored structure ubiquitously expressed in human cancers. (PMID: 11444831) Onda H. … Fujino M. (Biochem. Biophys. Res. Commun. 2001) 3 4
  5. Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells. (PMID: 19089914) Schwinn N. … Paschen A. (Int. J. Cancer 2009) 3 23

Products for ULBP2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ULBP2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ULBP2
    • Block miRNA regulation of ULBP2 using miScript Target Protectors

    Sources for ULBP2 Gene

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