Aliases for ULBP1 Gene
External Ids for ULBP1 Gene
GeneCards Summary for ULBP1 Gene
ULBP1 (UL16 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP3.
UniProtKB/Swiss-Prot for ULBP1 Gene
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.