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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ULBP1 Gene

protein-coding   GIFtS: 56
GCID: GC06P150285

UL16 binding protein 1
 Explore 17 diseases affiliated with
ULBP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ULBP1    

Aliases
for ULBP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UL16 Binding Protein 11 2     UL16-Binding Protein 12 3
RAET1I1 2 3     Alcan-Beta1
Retinoic Acid Early Transcript 1I2 3     NKG2D Ligand 12
N2DL-12 3     ALCAN-Beta1
NKG2DL12 3     N2DL13

External Ids:    HGNC: 148931   Entrez Gene: 803292   Ensembl: ENSG000001119817   OMIM: 6056975   UniProtKB: Q9BZM63   

Export aliases for ULBP1 gene to outside databases

Previous GC identifers: GC06P149846 GC06P150180 GC06P150316 GC06P150377 GC06P150326 GC06P147850


Summaries
for ULBP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
Function: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling
pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to
NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction
pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the
interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system.
UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface

Gene Wiki entry for ULBP1


Genomic Views
for ULBP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ULBP1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ULBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ULBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25

ULBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULBP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P150285:  view genomic region     (about GC identifiers)

Start:
 150,285,143 bp from pter      End:
 150,294,846 bp from pter
Size:
 9,704 bases      Orientation:
 plus strand

Proteins
for ULBP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6 (See protein sequence)
Recommended Name: NKG2D ligand 1 precursor  
Size: 244 amino acids; 27997 Da
Subunit: Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Detected intracellularly in
the endoplasmic reticulum of CMV-infected fibroblasts
Miscellaneous: The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the
alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides
Secondary accessions: Q5VY81 Q8IZW3 Q8IZX6

Explore the universe of human proteins at neXtProt for ULBP1: NX_Q9BZM6

ULBP1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_079494.1  
ENSEMBL proteins: 
 ENSP00000356314   ENSP00000229708  
Reactome Protein details: Q9BZM6
Human Recombinant Protein Products: 
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OriGene Custom Protein Services for ULBP1 
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Novus Biologicals ULBP1 Protein
Sino Biological Recombinant Protein for ULBP1
ProSpec Recombinant Protein for ULBP1
Uscn Proteins for ULBP1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IEA--
GO:0005886plasma membrane TAS--
GO:0016020membrane NAS--
GO:0031225anchored to membrane IEA--
GO:0042612MHC class I protein complex IEA--


ULBP1 for ontologies           About GeneDecksing



ULBP1 Antibody Products: 
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Uscn ELISAs and CLIAs for ULBP1

Protein Domains /
Families
for ULBP1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
ULBP1 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR011161 MHC_I-like_Ag-recog
 IPR011162 MHC_I/II-like_Ag-recog
 IPR001039 MHC_I_a_a1/a2

Graphical View of Domain Structure for InterPro Entry Q9BZM6

ProtoNet protein and cluster: Q9BZM6

1 Blocks protein family: IPB001039 MHC class I signature

UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
Similarity: Belongs to the MHC class I family


Function
for ULBP1 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
Function: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling
pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to
NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction
pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the
interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system.
UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ULBP1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ULBP1
SwitchGear 3'UTR luciferase reporter plasmid: ULBP1 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULBP1 (see all 4)
OriGene shRNA RFP: ULBP1
OriGene siRNA: ULBP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULBP1

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for ULBP1

Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULBP1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULBP1 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for ULBP1
Search LifeMap BioReagents cell lines for ULBP1

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULBP1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0032393MHC class I receptor activity NAS11239445


ULBP1 for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for ULBP1:
 Decreased Wnt reporter activit  Decreased number of cells in m 


Pathways & Interactions
for ULBP1 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Immune System
Immune System1.00
Adaptive Immune System0.59
2Natural killer cell mediated cytotoxicity
Natural killer cell mediated cytotoxicity1.00
3Cleavage of Alpha-1-Microglobulin
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

Pathway sources
See GeneCards unified pathways
Show all pathways


3        Reactome Pathways for ULBP1
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Immune System


1         Kegg Pathway  (Kegg details for ULBP1):
    Natural killer cell mediated cytotoxicity


ULBP1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ULBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for ULBP1 (Q9BZM63 ENSP000002297084) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
InteractantInteraction Details
GeneCardExternal ID(s)
KLRC4O439083, ENSP000003102164I2D: score=1 STRING: ENSP00000310216
RAET1GQ6H3X33, ENSP000003563294I2D: score=1 STRING: ENSP00000356329
HCSTENSP000002465514STRING: ENSP00000246551
KLRK1ENSP000002406184STRING: ENSP00000240618
AZGP1ENSP000002924014STRING: ENSP00000292401
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response IEA--
GO:0019882antigen processing and presentation IEA--
GO:0030101natural killer cell activation NAS11239445
GO:0050776regulation of immune response TAS--


ULBP1 for ontologies           About GeneDecksing



Drugs & Compounds
for ULBP1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ULBP1

1 HMDB Compound for ULBP1    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
Search CenterWatch for drugs/clinical trials and news about ULBP1 / N2DL1 

Transcripts
for ULBP1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for ULBP1 gene: 
NM_025218.2  

Unigene Cluster for ULBP1:

UL16 binding protein 1
Hs.653255  [show with all ESTs]
Unigene Representative Sequence: NM_025218
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000367345 ENST00000229708(uc003qnp.3)

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ULBP1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ULBP1
SwitchGear 3'UTR luciferase reporter plasmid: ULBP1 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ULBP1 (see all 4)
OriGene shRNA RFP: ULBP1
OriGene siRNA: ULBP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULBP1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ULBP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: ULBP1 (NM_025218)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULBP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULBP1 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ULBP1
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ULBP1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULBP1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULBP1

Additional cDNA sequence: 

AB052907.1 AF304377.1 AF346416.1 AF346595.1 AF425265.1 AK292519.1 AK316582.1 BC035416.1 

1 DOTS entry:

DT.75196580 

21 AceView cDNA sequences:

BC035416 AF425265 BM693861 BM670923 CK818897 AF346416 CA307463 AF346595 
AI830832 BG026119 AA676287 BM126307 BG719599 AB052907 AF304377 CK818896 
CF146566 NM_025218 BV173126 AA188922 AL705716 

GeneLoc Exon Structure


Expression
for ULBP1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ULBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

ULBP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
OvaryAntral FollicleCumulus CellsOvary
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See ULBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ULBP1

SOURCE GeneReport for Unigene cluster: Hs.653255

UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
Tissue specificity: Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including
heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung
and liver

    SABiosciences Custom PCR Arrays for ULBP1
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULBP1
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULBP1

Orthologs
for ULBP1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for ULBP1 (if available)
TreeFam Gene Tree for ULBP1 (if available) 

Paralogs
for ULBP1 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ULBP1 gene
RAET1G2  ULBP32  RAET1E2  RAET1L2  ULBP22  
8 SIMAP similar genes for ULBP1 using alignment to 1 protein entry:     N2DL1_HUMAN:
RAET1H    RAET1G    RAET1L    ULBP2    ULBP3    RAET-1E
RAET1E    HLA-B

ULBP1 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for ULBP1
PGOHUM00000243416 PGOHUM00000243817


Genomic Variants
for ULBP1 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/320 NCBI SNPs in ULBP1 are shown (see all 320)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 6 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1817357021,2
--150283159(+) ACCAGC/TTGACG 1 -- us2k10--------
rs104992611,2
C,F,A,H,--150283163(+) GCTGAC/TGGAGA 1 -- us2k1101Minor allele frequency- T:0.23NS NA EA PA EU CA WA 6360
rs1155021571,2
F,--150283186(+) TTTGTA/GGGTCT 1 -- us2k11Minor allele frequency- G:0.04WA 118
rs1855503691,2
--150283187(+) TTGTAA/GGTCTG 1 -- us2k10--------
rs737797041,2
C,--150283200(+) AAACGT/AGTCTG 1 -- us2k12Minor allele frequency- A:0.20WA 120
rs77407131,2
C,F,H,--150283294(+) GCTCCA/CGCTCT 1 -- us2k16Minor allele frequency- C:0.12NS NA WA EA 584
rs1904525211,2
--150283307(+) TCAGGA/GTGGGC 1 -- us2k10--------
rs1453035861,2
--150283310(+) GGGTG-/GGCCT 
        GGCAT 		1 -- us2k10--------
rs575517201,2
--150283353(+) TCACAA/GCTGAA 1 -- us2k10--------
rs1821644981,2
--150283397(+) AAGGAC/TAGGGT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ULBP1 (150285143 - 150294846 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ULBP1
     1 Indel: 47019
     1 Inversion: 29469

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ULBP1
DNA2.0 Custom Variant and Variant Library Synthesis for ULBP1

Disorders / Diseases
for ULBP1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
ULBP1 for disorders           About GeneDecksing

OMIM gene information: 605697    OMIM disorders: --

17 diseases for ULBP1:    About MalaCards
mhc class i deficiency    cytomegalovirus infection    chronic lymphocytic leukemia    acute myeloid leukemia
lymphocytic leukemia    leukemia/lymphoma    myeloid leukemia    malignant glioma
leukemia    tonsillitis    hepatitis b    lung adenocarcinoma
nasopharyngitis    adenocarcinoma    hepatitis    immunodeficiency
carcinoma

1 Novoseek disease relationship for ULBP1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 3.1 3 19414815 (1), 20101024 (1), 16237071 (1)

Human Genome Epidemiology (HuGE) Navigator: ULBP1 (4 documents)

Export disorders for ULBP1 gene to outside databases

Publications
for ULBP1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ULBP1 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with ULBP1)		    Utopia: connect your pdf to the dynamic
world of online information

  1. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PubMed id 11827464)1, 2, 3 Radosavljevic M.... Bahram S. (2002)
  2. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PubMed id 11239445)1, 2, 3 Cosman D.... Chalupny N.J. (2001)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. (PubMed id 12753652)1, 2 Cerwenka A. and Lanier L.L. (2003)
  5. Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. (PubMed id 12782710)1, 2 Dunn C.... Cosman D. (2003)
  6. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. (PubMed id 11777960)1, 2 Sutherland C.L....Cosman D. (2002)
  7. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. (PubMed id 11491531)1, 2 Steinle A....Spies T. (2001)
  8. Proteasome regulation of ULBP1 transcription. (PubMed id 19414815)1, 9 Butler J.E....Lutz C.T. (2009)
  9. Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein. (PubMed id 12847260)1, 9 Rolle A....Cerboni C. (2003)
  10. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP ge nes in northeastern Thais. (PubMed id 19688209)1, 9 Romphruk A.V....Leelayuwat C. (2009)

External Searches for ULBP1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing ULBP1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80329 HGNC: 14893 AceView: ULBP1 Ensembl:ENSG00000111981 euGenes: HUgn80329
ECgene: ULBP1 Kegg: 80329 H-InvDB: ULBP1

Other Databases showing ULBP1 gene

(According to HUGE)
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Specialized Databases showing ULBP1 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ULBP1 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for ULBP1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ULBP1 gene:
Search GeneIP for patents involving ULBP1

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Products
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