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Aliases for ULBP1 Gene

Aliases for ULBP1 Gene

  • UL16 Binding Protein 1 2 3 5
  • Retinoic Acid Early Transcript 1I 3 4
  • Alcan-Beta 3 4
  • NKG2DL1 3 4
  • N2DL-1 3 4
  • RAET1I 3 4
  • UL16-Binding Protein 1 4
  • NKG2D Ligand 1 3
  • N2DL1 4

External Ids for ULBP1 Gene

Previous GeneCards Identifiers for ULBP1 Gene

  • GC06P149846
  • GC06P150180
  • GC06P150316
  • GC06P150377
  • GC06P150326
  • GC06P150285
  • GC06P147850

Summaries for ULBP1 Gene

Entrez Gene Summary for ULBP1 Gene

  • The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for ULBP1 Gene

ULBP1 (UL16 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP2.

UniProtKB/Swiss-Prot for ULBP1 Gene

  • Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Gene Wiki entry for ULBP1 Gene

Additional gene information for ULBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULBP1 Gene

Genomics for ULBP1 Gene

Regulatory Elements for ULBP1 Gene

Enhancers for ULBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H149962 1.5 FANTOM5 ENCODE 28.8 +0.2 192 3 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF302 FOS ZNF548 SP3 LATS1 NUP43 ULBP1 PPIL4 KATNA1 ENSG00000219298 RAET1K PHBP1 ENSG00000235972 ENSG00000216906
GH06H150004 1.1 ENCODE 18.2 +41.1 41145 1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 LATS1 PPIL4 ENSG00000233330 RPS18P9 ULBP1 NUP43 KATNA1 GINM1 TAB2 ENSG00000231760
GH06H150007 0.8 ENCODE 13.3 +43.3 43283 0 HDGF CTCF BATF RAD21 ZNF2 ZFHX2 EGR1 EED SCRT2 ZNF143 ULBP1 RAET1L RAET1K
GH06H149937 1.1 Ensembl ENCODE 9.4 -25.5 -25465 1 ZFP64 BMI1 ZNF207 ATF7 ETV6 RUNX3 CREM IKZF2 CBFB ZNF217 ULBP2 ULBP1 RAET1K LOC105378052
GH06H149858 1.6 Ensembl ENCODE dbSUPER 5.1 -101.9 -101905 6 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ENSG00000216906 ENSG00000231760 RAET1E LATS1 NUP43 LRP11 ULBP1 ENSG00000268592 ENSG00000273132
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ULBP1 on UCSC Golden Path with GeneCards custom track

Promoters for ULBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000205100 -307 601 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF302 FOS ZNF548 SP3

Genomic Location for ULBP1 Gene

Chromosome:
6
Start:
149,964,007 bp from pter
End:
149,973,710 bp from pter
Size:
9,704 bases
Orientation:
Plus strand

Genomic View for ULBP1 Gene

Genes around ULBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULBP1 Gene

Proteins for ULBP1 Gene

  • Protein details for ULBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM6-N2DL1_HUMAN
    Recommended name:
    NKG2D ligand 1
    Protein Accession:
    Q9BZM6
    Secondary Accessions:
    • Q5VY81
    • Q8IZW3
    • Q8IZX6

    Protein attributes for ULBP1 Gene

    Size:
    244 amino acids
    Molecular mass:
    27997 Da
    Quaternary structure:
    • Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.
    Miscellaneous:
    • The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.

neXtProt entry for ULBP1 Gene

Post-translational modifications for ULBP1 Gene

Other Protein References for ULBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ULBP1
  • Santa Cruz Biotechnology (SCBT) Antibodies for ULBP1

No data available for DME Specific Peptides for ULBP1 Gene

Domains & Families for ULBP1 Gene

Gene Families for ULBP1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ULBP1 Gene

Suggested Antigen Peptide Sequences for ULBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZM6

UniProtKB/Swiss-Prot:

N2DL1_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with ULBP1: view

Function for ULBP1 Gene

Molecular function for ULBP1 Gene

UniProtKB/Swiss-Prot Function:
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Phenotypes From GWAS Catalog for ULBP1 Gene

Gene Ontology (GO) - Molecular Function for ULBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046703 natural killer cell lectin-like receptor binding IDA 11239445
genes like me logo Genes that share ontologies with ULBP1: view
genes like me logo Genes that share phenotypes with ULBP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ULBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ULBP1 Gene

Localization for ULBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULBP1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ULBP1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
endoplasmic reticulum 4
cytosol 4
extracellular 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ULBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0015629 actin cytoskeleton IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ULBP1: view

Pathways & Interactions for ULBP1 Gene

genes like me logo Genes that share pathways with ULBP1: view

Interacting Proteins for ULBP1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000229708%0d%0a9606.ENSP00000240618%0d%0a9606.ENSP00000246551%0d%0a9606.ENSP00000356308%0d%0a9606.ENSP00000356320%0d%0a9606.ENSP00000310216%0d%0a
Selected Interacting proteins: Q9BZM6-N2DL1_HUMAN ENSP00000229708 for ULBP1 Gene via IID STRING

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
KLRC4

Gene Ontology (GO) - Biological Process for ULBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030101 natural killer cell activation IDA 11239445
GO:0042267 natural killer cell mediated cytotoxicity IDA 11239445
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with ULBP1: view

No data available for SIGNOR curated interactions for ULBP1 Gene

Drugs & Compounds for ULBP1 Gene

(1) Drugs for ULBP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ULBP1: view

Transcripts for ULBP1 Gene

mRNA/cDNA for ULBP1 Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ULBP1 Gene

UL16 binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ULBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ULBP1 Gene

No ASD Table

Relevant External Links for ULBP1 Gene

GeneLoc Exon Structure for
ULBP1
ECgene alternative splicing isoforms for
ULBP1

Expression for ULBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ULBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULBP1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.8) and Brain - Cerebellum (x7.5).

Protein differential expression in normal tissues from HIPED for ULBP1 Gene

This gene is overexpressed in Serum (45.0) and Tlymphocyte (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ULBP1 Gene



Protein tissue co-expression partners for ULBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ULBP1 Gene:

ULBP1

SOURCE GeneReport for Unigene cluster for ULBP1 Gene:

Hs.653255

mRNA Expression by UniProt/SwissProt for ULBP1 Gene:

Q9BZM6-N2DL1_HUMAN
Tissue specificity: Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

Evidence on tissue expression from TISSUES for ULBP1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ULBP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ULBP1 Gene

Orthologs for ULBP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ULBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULBP1 33 34
  • 99.45 (n)
mouse
(Mus musculus)
Mammalia Ulbp1 33 16
  • 59.76 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 34 (a)
OneToMany
Species where no ortholog for ULBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ULBP1 Gene

ENSEMBL:
Gene Tree for ULBP1 (if available)
TreeFam:
Gene Tree for ULBP1 (if available)

Paralogs for ULBP1 Gene

Paralogs for ULBP1 Gene

(8) SIMAP similar genes for ULBP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ULBP1 Gene

genes like me logo Genes that share paralogs with ULBP1: view

Variants for ULBP1 Gene

Sequence variations from dbSNP and Humsavar for ULBP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000192900 -- 149,969,843(+) AGGGC(A/G)GGGGA intron-variant
rs1000641477 -- 149,966,442(+) CTATG(C/G)TTCTG intron-variant
rs1001408133 -- 149,962,429(+) CCATT(A/G/T)CAATA upstream-variant-2KB
rs1001750842 -- 149,971,651(+) AACAA(A/G)AAATC nc-transcript-variant, utr-variant-3-prime
rs1002409124 -- 149,963,553(+) GCTCC(C/G)GAATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ULBP1 Gene

Variant ID Type Subtype PubMed ID
esv2217053 CNV deletion 18987734
esv2672704 CNV deletion 23128226
esv2732866 CNV deletion 23290073
esv2732867 CNV deletion 23290073
esv2732868 CNV deletion 23290073
esv2732869 CNV deletion 23290073
esv3611218 CNV loss 21293372
esv3890963 CNV loss 25118596
nsv1116475 OTHER inversion 24896259
nsv1121657 CNV deletion 24896259
nsv436711 OTHER inversion 17901297
nsv517022 CNV gain+loss 19592680
nsv970175 CNV duplication 23825009

Variation tolerance for ULBP1 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ULBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ULBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULBP1 Gene

Disorders for ULBP1 Gene

Relevant External Links for ULBP1

Genetic Association Database (GAD)
ULBP1
Human Genome Epidemiology (HuGE) Navigator
ULBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ULBP1

No disorders were found for ULBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULBP1 Gene

Publications for ULBP1 Gene

  1. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A … Briggs DC (Human immunology 2010) 3 22 45 60
  2. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk AV … Leelayuwat C (Immunogenetics 2009) 3 22 45 60
  3. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PMID: 11827464) Radosavljevic M … Bahram S (Genomics 2002) 2 3 4 60
  4. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PMID: 11239445) Cosman D … Chalupny NJ (Immunity 2001) 2 3 4 60
  5. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PMID: 20923822) Niu N … Wang L (Genome research 2010) 3 45 60

Products for ULBP1 Gene

Sources for ULBP1 Gene

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