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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ULBP1 Gene

protein-coding   GIFtS: 59
GCID: GC06P150285

UL16 Binding Protein 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UL16 Binding Protein 11 2     UL16-Binding Protein 12 3
Retinoic Acid Early Transcript 1I2 3     alcan-beta2
N2DL-12 3     NKG2D Ligand 12
NKG2DL12 3     ALCAN-beta3
RAET1I2 3     N2DL13

External Ids:    HGNC: 148931   Entrez Gene: 803292   Ensembl: ENSG000001119817   OMIM: 6056975   UniProtKB: Q9BZM63   

Export aliases for ULBP1 gene to outside databases

Previous GC identifers: GC06P149846 GC06P150180 GC06P150316 GC06P150377 GC06P150326 GC06P147850


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ULBP1 Gene: 
ULBP1 (UL16 binding protein 1) is a protein-coding gene. Diseases associated with ULBP1 include mhc class i deficiency, and cytomegalovirus infection, and among its related super-pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include MHC class I receptor activity. An important paralog of this gene is RAET1G.

UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
Function: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling
pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands
to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal
transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with
UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might
escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does
not reach the cell surface

Gene Wiki entry for ULBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ULBP1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidULBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ULBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ULBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25

ULBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULBP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P150285:  view genomic region     (about GC identifiers)

Start:
150,285,143 bp from pter      End:
150,294,846 bp from pter
Size:
9,704 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6 (See protein sequence)
Recommended Name: NKG2D ligand 1 precursor  
Size: 244 amino acids; 27997 Da
Subunit: Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Detected
intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts
Miscellaneous: The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain
the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides
Secondary accessions: Q5VY81 Q8IZW3 Q8IZX6

Explore the universe of human proteins at neXtProt for ULBP1: NX_Q9BZM6

Explore proteomics data for ULBP1 at MOPED 

ULBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ULBP1 Protein Expression

REFSEQ proteins: NP_079494.1  
ENSEMBL proteins: 
 ENSP00000356314   ENSP00000229708  
Reactome Protein details: Q9BZM6
Human Recombinant Protein Products for ULBP1: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for ULBP1 (ULBP-1)
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Novus Biologicals ULBP1 Proteins
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Sino Biological Cell Lysate for ULBP1 
ProSpec Recombinant Protein for ULBP1
Cloud-Clone Corp. Proteins for ULBP1 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IEA--
GO:0005886plasma membrane TAS--
GO:0042612MHC class I protein complex ----
GO:0046658anchored to plasma membrane IDA11239445

ULBP1 for ontologies           About GeneDecksing



ULBP1 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for ULBP1 

Assay Products for ULBP1: 
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Cloud-Clone Corp. ELISAs for ULBP1 
Cloud-Clone Corp. CLIAs for ULBP1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR011161 MHC_I-like_Ag-recog
 IPR011162 MHC_I/II-like_Ag-recog
 IPR001039 MHC_I_a_a1/a2

Graphical View of Domain Structure for InterPro Entry Q9BZM6

ProtoNet protein and cluster: Q9BZM6

1 Blocks protein domain: IPB001039 MHC class I signature

UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
Similarity: Belongs to the MHC class I family


ULBP1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: N2DL1_HUMAN, Q9BZM6
Function: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling
pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands
to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal
transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with
UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might
escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does
not reach the cell surface

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IBA--
GO:0046703natural killer cell lectin-like receptor binding IDA11239445
     
ULBP1 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ULBP1:
 Decreased Wnt reporter activit  Decreased number of cells in m 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for ULBP1 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ULBP1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ULBP1 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ULBP1
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of ULBP1

Clone
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GenScript: all cDNA clones in your preferred vector: ULBP1 (NM_025218)
Sino Biological Human cDNA Clone for ULBP1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULBP1
Sirion Biotech Customized lentivirus for stable overexpression of ULBP1 
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULBP1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ULBP1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune System
Immune System0.56
Adaptive Immune System0.56
2Immune response Fc epsilon RI pathway
Natural killer cell mediated cytotoxicity0.31
3Classical antibody-mediated complement activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



3        Reactome Pathways for ULBP1
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Immune System


1         Kegg Pathway  (Kegg details for ULBP1):
    Natural killer cell mediated cytotoxicity


ULBP1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ULBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for ULBP1 (Q9BZM63 ENSP000002297084) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
InteractantInteraction Details
GeneCardExternal ID(s)
KLRC4O439083, ENSP000003102164I2D: score=1 STRING: ENSP00000310216
RAET1GQ6H3X33, ENSP000003563294I2D: score=1 STRING: ENSP00000356329
HCSTENSP000002465514STRING: ENSP00000246551
KLRK1ENSP000002406184STRING: ENSP00000240618
AZGP1ENSP000002924014STRING: ENSP00000292401
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response ----
GO:0019882antigen processing and presentation IBA--
GO:0030101natural killer cell activation IDA11239445
GO:0042267natural killer cell mediated cytotoxicity IDA11239445
GO:0050776regulation of immune response TAS--

ULBP1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ULBP1 (N2DL1)

1 HMDB Compound for ULBP1    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

Search CenterWatch for drugs/clinical trials and news about ULBP1 / N2DL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ULBP1 gene: 
NM_025218.2  

Unigene Cluster for ULBP1:

UL16 binding protein 1
Hs.653255  [show with all ESTs]
Unigene Representative Sequence: NM_025218
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000367345 ENST00000229708(uc003qnp.3)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ULBP1
SwitchGear 3'UTR luciferase reporter plasmidULBP1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for ULBP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ULBP1
Clone
Products:
     
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OriGene ORF clones in mouse, rat for ULBP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ULBP1 (NM_025218)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ULBP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ULBP1
Sirion Biotech Customized lentivirus for stable overexpression of ULBP1 
                     Customized lentivirus expression plasmids for stable overexpression of ULBP1 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for ULBP1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ULBP1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ULBP1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULBP1

Additional mRNA sequence: 

AB052907.1 AF304377.1 AF346416.1 AF346595.1 AF425265.1 AK292519.1 AK316582.1 BC035416.1 

1 DOTS entry:

DT.75196580 

21 AceView cDNA sequences:

AI830832 AF425265 CK818897 BC035416 BM693861 AF346416 BM670923 CA307463 
AF346595 AB052907 BM126307 AA676287 CF146566 AF304377 NM_025218 CK818896 
BV173126 BG719599 BG026119 AL705716 AA188922 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ULBP1 expression in normal human tissues (normalized intensities)      ULBP1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ULBP1 Expression
About this image


ULBP1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Ovary (Reproductive System)
         Cumulus Cells Antral Follicle

See ULBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ULBP1

SOURCE GeneReport for Unigene cluster: Hs.653255

UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
Tissue specificity: Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues
including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal
heart, brain, lung and liver

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ULBP1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ULBP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for ULBP1 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ulbp11 , 5 UL16 binding protein 11, 5 57.71(n)1
31.34(a)1
  105
777771  NM_029975.21  NP_084251.11 
 74448735 


ENSEMBL Gene Tree for ULBP1 (if available)
TreeFam Gene Tree for ULBP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ULBP1 gene
RAET1G2  ULBP32  RAET1L2  RAET1E2  ULBP22  
8 SIMAP similar genes for ULBP1 using alignment to 1 protein entry:     N2DL1_HUMAN:
RAET1H    RAET1G    RAET1L    ULBP2    ULBP3    RAET-1E
RAET1E    HLA-B

ULBP1 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for ULBP1
PGOHUM00000243416 PGOHUM00000243817


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/410 SNPs in ULBP1 are shown (see all 410)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1817357021,2
--150283159(+) ACCAGC/TTGACG 1 -- us2k10--------
rs104992611,2
C,F,A,H--150283163(+) GCTGAC/TGGAGA 1 -- us2k1101Minor allele frequency- T:0.23NS NA EA PA EU CA WA 6360
rs1155021571,2
C,F--150283186(+) TTTGTA/GGGTCT 1 -- us2k11Minor allele frequency- G:0.04WA 118
rs1855503691,2
--150283187(+) TTGTAA/GGTCTG 1 -- us2k10--------
rs737797041,2
C,F--150283200(+) AAACGT/AGTCTG 1 -- us2k12Minor allele frequency- A:0.20WA 120
rs77407131,2
C,F,H--150283294(+) GCTCCA/CGCTCT 1 -- us2k16Minor allele frequency- C:0.12NS NA WA EA 584
rs1904525211,2
--150283307(+) TCAGGA/GTGGGC 1 -- us2k10--------
rs1453035861,2
C--150283310(+) GGGTG-/GGCCT 
        
GGCAT
1 -- us2k10--------
rs600355031,2
C--150283313(+) TGGGC-/CTGGC 
        
ATTTG
1 -- us2k10--------
rs575517201,2
C--150283353(+) TCACAA/GCTGAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ULBP1 (150285143 - 150294846 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for ULBP1:    About this table     
Variant IDTypeSubtypePubMed ID
esv2732866CNV Deletion23290073
esv2672704CNV Deletion23128226
esv2732868CNV Deletion23290073
esv2217053CNV Deletion18987734
esv2732869CNV Deletion23290073
esv2732867CNV Deletion23290073
nsv886764CNV Loss21882294
nsv886765CNV Gain21882294
nsv517022CNV Gain+Loss19592680
nsv436711OTHER Inversion17901297

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing ULBP1
DNA2.0 Custom Variant and Variant Library Synthesis for ULBP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605697    OMIM disorders: --

14 diseases for ULBP1:    About MalaCards
mhc class i deficiency    cytomegalovirus infection    tonsillitis    lung adenocarcinoma
malignant glioma    nasopharyngitis    acute myeloid leukemia    chronic lymphocytic leukemia
myeloid leukemia    hepatitis b    leukemia    adenocarcinoma
hepatitis    endotheliitis


ULBP1 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for ULBP1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 3.1 3 19414815 (1), 20101024 (1), 16237071 (1)

Genetic Association Database (GAD): ULBP1
Human Genome Epidemiology (HuGE) Navigator: ULBP1 (4 documents)

Export disorders for ULBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ULBP1 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with ULBP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PubMed id 11827464)1, 2, 3 Radosavljevic M.... Bahram S. (2002)
  2. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PubMed id 11239445)1, 2, 3 Cosman D.... Chalupny N.J. (2001)
  3. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP ge nes in northeastern Thais. (PubMed id 19688209)1, 4, 9 Romphruk A.V....Leelayuwat C. (2009)
  4. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evi dence of diversity between human populations. (PubMed id 20219610)1, 4, 9 Antoun A....Briggs D.C. (2010)
  5. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)1, 4 Niu N....Wang L. (2010)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. (PubMed id 12753652)1, 2 Cerwenka A. and Lanier L.L. (2003)
  8. Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. (PubMed id 12782710)1, 2 Dunn C.... Cosman D. (2003)
  9. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. (PubMed id 11777960)1, 2 Sutherland C.L....Cosman D. (2002)
  10. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. (PubMed id 11491531)1, 2 Steinle A....Spies T. (2001)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80329 HGNC: 14893 AceView: ULBP1 Ensembl:ENSG00000111981 euGenes: HUgn80329
ECgene: ULBP1 Kegg: 80329 H-InvDB: ULBP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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NameDescription
PharmGKB entry for ULBP1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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