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ULBP1 Gene

protein-coding   GIFtS: 59
GCID: GC06P150285

UL16 Binding Protein 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UL16 Binding Protein 11 2     UL16-Binding Protein 12 3
Retinoic Acid Early Transcript 1I2 3     alcan-beta2
N2DL-12 3     NKG2D Ligand 12
NKG2DL12 3     ALCAN-beta3
RAET1I2 3     N2DL13

External Ids:    HGNC: 148931   Entrez Gene: 803292   Ensembl: ENSG000001119817   OMIM: 6056975   UniProtKB: Q9BZM63   

Export aliases for ULBP1 gene to outside databases

Previous GC identifers: GC06P149846 GC06P150180 GC06P150316 GC06P150377 GC06P150326 GC06P147850


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ULBP1 Gene:
ULBP1 (UL16 binding protein 1) is a protein-coding gene. Diseases associated with ULBP1 include mhc class i deficiency, and cytomegalovirus infection. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1G.

UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
Function: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling
pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands
to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal
transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with
UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might
escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does
not reach the cell surface

Gene Wiki entry for ULBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ULBP1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidULBP1 promoter sequence
   Search Chromatin IP Primers for ULBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ULBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25

ULBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ULBP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P150285:  view genomic region     (about GC identifiers)

Start:
150,285,143 bp from pter      End:
150,294,846 bp from pter
Size:
9,704 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6 (See protein sequence)
Recommended Name: NKG2D ligand 1 precursor  
Size: 244 amino acids; 27997 Da
Subunit: Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin
Miscellaneous: The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain
the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides
Secondary accessions: Q5VY81 Q8IZW3 Q8IZX6

Explore the universe of human proteins at neXtProt for ULBP1: NX_Q9BZM6

Explore proteomics data for ULBP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn82

  • See ULBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079494.1  
    ENSEMBL proteins: 
     ENSP00000229708  
    Reactome Protein details: Q9BZM6

    ULBP1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ULBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011162 MHC_I/II-like_Ag-recog
     IPR011161 MHC_I-like_Ag-recog
     IPR001039 MHC_I_a_a1/a2

    Graphical View of Domain Structure for InterPro Entry Q9BZM6

    ProtoNet protein and cluster: Q9BZM6

    1 Blocks protein domain: IPB001039 MHC class I signature

    UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
    Similarity: Belongs to the MHC class I family


    ULBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: N2DL1_HUMAN, Q9BZM6
    Function: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling
    pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands
    to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal
    transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with
    UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might
    escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does
    not reach the cell surface

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IBA--
    GO:0046703natural killer cell lectin-like receptor binding IDA11239445
         
    ULBP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ULBP1:
     Decreased Wnt reporter activit  Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ULBP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ULBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ULBP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    N2DL1_HUMAN, Q9BZM6: Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Detected
    intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    extracellular2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0046658anchored component of plasma membrane IDA11239445

    ULBP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ULBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31
    3Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ULBP1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    1 Kegg Pathway  (Kegg details for ULBP1):
        Natural killer cell mediated cytotoxicity


    ULBP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ULBP1
    Interactions:

        Search GeneGlobe Interaction Network for ULBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ULBP1 (Q9BZM63 ENSP000002297084) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLRC4O439083, ENSP000003102164I2D: score=1 STRING: ENSP00000310216
    RAET1GQ6H3X33, ENSP000003563294I2D: score=1 STRING: ENSP00000356329
    HCSTENSP000002465514STRING: ENSP00000246551
    KLRK1ENSP000002406184STRING: ENSP00000240618
    AZGP1ENSP000002924014STRING: ENSP00000292401
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0019882antigen processing and presentation IBA--
    GO:0030101natural killer cell activation IDA11239445
    GO:0042267natural killer cell mediated cytotoxicity IDA11239445
    GO:0050776regulation of immune response TAS--

    ULBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ULBP1 (N2DL1)

    1 HMDB Compound for ULBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ULBP1 gene: 
    NM_025218.2  

    Unigene Cluster for ULBP1:

    UL16 binding protein 1
    Hs.653255  [show with all ESTs]
    Unigene Representative Sequence: NM_025218
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229708(uc003qnp.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ULBP1
      QuantiFast Probe-based Assays in human, mouse, rat ULBP1

    Additional mRNA sequence: 

    AB052907.1 AF304377.1 AF346416.1 AF346595.1 AF425265.1 AK292519.1 AK316582.1 BC035416.1 

    1 DOTS entry:

    DT.75196580 

    21 AceView cDNA sequences:

    BC035416 AF425265 CA307463 AF346416 CK818897 AF346595 AI830832 BM670923 
    BM693861 BG719599 BG026119 BM126307 CF146566 BV173126 AA676287 AF304377 
    AB052907 CK818896 NM_025218 AA188922 AL705716 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ULBP1 expression in normal human tissues (normalized intensities)      ULBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ULBP1 Expression
    About this image


    ULBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
    ULBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ULBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653255

    UniProtKB/Swiss-Prot: N2DL1_HUMAN, Q9BZM6
    Tissue specificity: Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues
    including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal
    heart, brain, lung and liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ULBP1 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ulbp11 , 5 UL16 binding protein 11, 5 59.76(n)1
    33.73(a)1
      105
    777771  NM_029975.21  NP_084251.11 
     74448735 


    ENSEMBL Gene Tree for ULBP1 (if available)
    TreeFam Gene Tree for ULBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ULBP1 gene
    RAET1G2  ULBP32  RAET1L2  RAET1E2  ULBP22  
    8 SIMAP similar genes for ULBP1 using alignment to 1 protein entry:     N2DL1_HUMAN:
    RAET1H    RAET1G    RAET1L    ULBP2    ULBP3    RAET-1E
    RAET1E    HLA-B

    ULBP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ULBP1
    PGOHUM00000243416 PGOHUM00000243817


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ULBP1 (see all 410)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817357021,2
    --150283159(+) ACCAGC/TTGACG 1 -- us2k10--------
    rs104992611,2
    C,F,A,H--150283163(+) GCTGAC/TGGAGA 1 -- us2k1101Minor allele frequency- T:0.23NS NA EA PA EU CA WA 6360
    rs1155021571,2
    C,F--150283186(+) TTTGTA/GGGTCT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1855503691,2
    --150283187(+) TTGTAA/GGTCTG 1 -- us2k10--------
    rs737797041,2
    C,F--150283200(+) AAACGT/AGTCTG 1 -- us2k12Minor allele frequency- A:0.20WA 120
    rs77407131,2
    C,F,H--150283294(+) GCTCCA/CGCTCT 1 -- us2k16Minor allele frequency- C:0.12NS NA WA EA 584
    rs1904525211,2
    --150283307(+) TCAGGA/GTGGGC 1 -- us2k10--------
    rs1453035861,2
    C--150283310(+) GGGTG-/GGCCT 
            
    GGCAT
    1 -- us2k10--------
    rs600355031,2
    C--150283313(+) TGGGC-/CTGGC 
            
    ATTTG
    1 -- us2k10--------
    rs575517201,2
    C--150283353(+) TCACAA/GCTGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ULBP1 (150285143 - 150294846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ULBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732866CNV Deletion23290073
    esv2672704CNV Deletion23128226
    esv2732868CNV Deletion23290073
    esv2217053CNV Deletion18987734
    esv2732869CNV Deletion23290073
    esv2732867CNV Deletion23290073
    nsv886764CNV Loss21882294
    nsv886765CNV Gain21882294
    nsv517022CNV Gain+Loss19592680
    nsv436711OTHER Inversion17901297

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605697    OMIM disorders: --

    17 diseases for ULBP1:    About MalaCards
    mhc class i deficiency    cytomegalovirus infection    tonsillitis    lung adenocarcinoma
    malignant glioma    nasopharyngitis    acute myeloid leukemia    hiv-1
    chronic lymphocytic leukemia    acute leukemia    myeloid leukemia    hepatitis b
    leukemia    adenocarcinoma    hepatitis    endotheliitis
    hepatocellular carcinoma


    ULBP1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ULBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 3.1 3 19414815 (1), 20101024 (1), 16237071 (1)

    Genetic Association Database (GAD): ULBP1
    Human Genome Epidemiology (HuGE) Navigator: ULBP1 (4 documents)

    Export disorders for ULBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ULBP1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with ULBP1)
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    1. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PubMed id 11827464)1, 2, 3 Radosavljevic M.... Bahram S. (Genomics 2002)
    2. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PubMed id 11239445)1, 2, 3 Cosman D.... Chalupny N.J. (Immunity 2001)
    3. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PubMed id 19688209)1, 4, 9 Romphruk A.V.... Leelayuwat C. (Immunogenetics 2009)
    4. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PubMed id 20219610)1, 4, 9 Antoun A....Briggs D.C. (Hum. Immunol. 2010)
    5. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)1, 4 Niu N....Wang L. (Genome Res. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. (PubMed id 12753652)1, 2 Cerwenka A. and Lanier L.L. (Tissue Antigens 2003)
    8. Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. (PubMed id 12782710)1, 2 Dunn C.... Cosman D. (J. Exp. Med. 2003)
    9. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. (PubMed id 11777960)1, 2 Sutherland C.L....Cosman D. (J. Immunol. 2002)
    10. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. (PubMed id 11491531)1, 2 Steinle A....Spies T. (Immunogenetics 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80329 HGNC: 14893 AceView: ULBP1 Ensembl:ENSG00000111981 euGenes: HUgn80329
    ECgene: ULBP1 Kegg: 80329 H-InvDB: ULBP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ULBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ULBP1 gene:
    Search GeneIP for patents involving ULBP1

    GeneCards and IP:
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