Aliases for UIMC1 Gene
External Ids for UIMC1 Gene
Previous GeneCards Identifiers for UIMC1 Gene
This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for UIMC1 Gene
UIMC1 (Ubiquitin Interaction Motif Containing 1) is a Protein Coding gene. Diseases associated with UIMC1 include Familial Breast Cancer. Among its related pathways are DNA Double-Strand Break Repair and Deubiquitination. GO annotations related to this gene include histone binding and K63-linked polyubiquitin binding.
UniProtKB/Swiss-Prot for UIMC1 Gene
Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds Lys-63-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than Lys-63-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.