UIMC1 Gene
protein-coding GIFtS: 54
GCID: GC05M176265
|
|
ubiquitin interaction motif containing 1
| |
Aliases for UIMC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ubiquitin Interaction Motif Containing 11 2 | | X2HRIP1102 | | RAP801 2 3 5 | | BRCA1-A Complex Subunit RAP802 | | Receptor-Associated Protein 802 3 | | Receptor Associated Protein 802 | | Retinoid X Receptor-Interacting Protein 1102 3 | | Retinoid X Receptor Interacting Protein2 | | Ubiquitin Interaction Motif-Containing Protein 12 3 | | RXRIP1103 |
Export aliases for UIMC1 gene to outside databasesPrevious GC identifer: GC05M171254 |
Summaries for UIMC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: UIMC1_HUMAN, Q96RL1Function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a centralrole in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesionssites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). TheBRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histonesH2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interactwith monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bindLys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1with the corepressor NCOR1 Gene Wiki entry for UIMC1
|
Genomic Views for UIMC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UIMC1 gene promoter: Spz1 NF-1 NF-1/L Pbx1a Arnt HNF-4alpha1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 Other transcription factors
Search SABiosciences Chromatin IP Primers for UIMC1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UIMC1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.2 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.2UIMC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M176265: view genomic region
(about GC identifiers)
Start:
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176,332,006 bp from pter |
End:
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176,449,634 bp from pter |
Size:
|
117,629 bases |
Orientation:
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minus strand |
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Proteins for UIMC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: UIMC1_HUMAN, Q96RL1 (See
protein sequence)Recommended Name: BRCA1-A complex subunit RAP80 Size: 719 amino acids; 79727 Da
Subunit: Interacts with TSP57 (By similarity). Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1,UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directlywith FAM175A/Abraxas. Interacts with ESR1, NR6A1 and UBE2I
Subcellular location: Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
Sequence caution: Sequence=AAH06078.1; Type=Erroneous termination; Positions=386; Note=Translated as Glu;
1 PDB 3D structure from and Proteopedia for UIMC1:2RR9 (3D)
 
Secondary accessions: A8MSA1 B3KMZ1 B4E3N2 Q5XKQ1 Q7Z3W7 Q8N5B9 Q9BZR1 Q9BZR5 Q9UHX7Alternative splicing: 5 isoforms: Q96RL1-1 Q96RL1-2 Q96RL1-3 Q96RL1-4 Q96RL1-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UIMC1: NX_Q96RL1
Post-translational modifications:
Sumoylated1
Phosphorylated upon DNA damage by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RL1 UIMC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186226.1 NP_001186227.1 NP_057374.3 ENSEMBL proteins: ENSP00000366434 ENSP00000427480 ENSP00000421926 ENSP00000425566 ENSP00000423717 ENSP00000423885 ENSP00000425163 ENSP00000423534 ENSP00000366425 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
UIMC1 for ontologies About GeneDecksing
UIMC1 Antibody Products: Assay Products for UIMC1: |
Protein
Domains / Families for UIMC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UIMC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96RL1ProtoNet protein and cluster: Q96RL1 UniProtKB/Swiss-Prot: UIMC1_HUMAN, Q96RL1Domain: The UIM-linker region between the 2 UIM repeats determines the selectivity for 'Lys-63'-linked ubiquitin. Thelength of the linker is important. The linker reduces the flexibility between the UIM repeats and promoteshigh-affinity and linkage-selective interactionsDomain: The Abraxas-interacting region (AIR) mediates the interaction with FAM175A/AbraxasSimilarity: Belongs to the RAP80 familySimilarity: Contains 2 UIM (ubiquitin-interacting motif) repeats |
Function for UIMC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: UIMC1_HUMAN, Q96RL1Function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a centralrole in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesionssites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). TheBRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histonesH2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interactwith monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bindLys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1with the corepressor NCOR1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UIMC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UIMC1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): UIMC1 (NM_016290) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UIMC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UIMC1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UIMC1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UIMC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UIMC1: Animal Models: Mouse knock-out Uimc1tm1.2Amj for UIMC1 5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Uimc1):
UIMC1 for phenotypes About GeneDecksing
|
Pathways & Interactions for UIMC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UIMC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/72 Interacting proteins for UIMC1 (Q96RL11, 2, 3 ENSP000003664344) via UniProtKB, MINT, STRING, and/or I2D (see all 72)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| FAM175A | Q6UWZ71, 3, ENSP000003698574 | EBI-1263554,EBI-1263451 I2D:
score=3 STRING: ENSP00000369857 | | BRCA1 | P383981, 3, ENSP000003502834 | EBI-1263554,EBI-349905 I2D:
score=2 STRING: ENSP00000350283 | | SKIL | P127572, 3 | MINT-61671 I2D:
score=3 | | INO80B | Q9C0862, 3, ENSP000002333314 | MINT-65401 I2D:
score=4 STRING: ENSP00000233331 | | BABAM1 | Q9NWV83, ENSP000003524084 | I2D:
score=2 STRING: ENSP00000352408 | About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
UIMC1 for ontologies About GeneDecksing
|
Drugs & Compounds for UIMC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for UIMC1 Search CenterWatch for drugs/clinical trials and news about UIMC1 
|
Transcripts for UIMC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for UIMC1 gene (3 alternative transcripts): NM_001199297.1 NM_001199298.1 NM_016290.4 Unigene Cluster for UIMC1: Ubiquitin interaction motif containing 1 Hs.232721 [show with all ESTs]Unigene Representative Sequence: NM_00119929715 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377227 ENST00000506128(uc003mff.1) ENST00000511320(uc021yim.1 uc021yin.1 uc003mfd.2 uc021yio.1) ENST00000512031 ENST00000510698 ENST00000510376 ENST00000505229 ENST00000503273(uc003mfe.1) ENST00000509236 ENST00000417486(uc011dfq.2) ENST00000515488 ENST00000507513 ENST00000505879 ENST00000428382 ENST00000377219(uc021yil.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UIMC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UIMC1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): UIMC1 (NM_016290) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UIMC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UIMC1  |
Additional cDNA sequence: AF113538.1 AF349313.1 AK023044.1 AL137375.1 BC006078.1 BC032561.1 BX537376.1 EF077642.1 EF077644.1 18 DOTS entries: DT.448450 DT.100706920 DT.100797224 DT.91743988 DT.120835395 DT.100797223 DT.100735665 DT.75114551 DT.95169141 DT.100797225 DT.120835400 DT.437280 DT.120835407 DT.40121349 DT.91743992 DT.97846275 DT.86839969 DT.95256616 24/230 AceView cDNA sequences (see all 230): CB240789 CR619611 T32711 BQ028902 W72995 BE551893 BM458702 BU621261 CB124487 W76232 BE258193 BU633201 BX104844 Z44350 AA307853 BU616946 BC006078 NM_016290 AA461498 BM997459 AA337563 CB162258 BX433798 BF724720 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UIMC1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17 | |
| SP1: | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   |
ECgene alternative splicing isoforms for UIMC1
|
Expression for UIMC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UIMC1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See UIMC1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UIMC1
SOURCE GeneReport for Unigene cluster: Hs.232721 UniProtKB/Swiss-Prot: UIMC1_HUMAN, Q96RL1Tissue specificity: Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis SABiosciences Custom PCR Arrays for UIMC1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UIMC1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UIMC1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UIMC1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UIMC1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UIMC1 |
Orthologs for UIMC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for UIMC1 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for UIMC1 (if available) TreeFam Gene Tree for UIMC1 (if available)  |
Paralogs for UIMC1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for UIMC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for UIMC1 (176332006 - 176449634 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for UIMC1 6 CNVs: 99370 44193 22514 39437 43477 62459 Human Gene Mutation Database (HGMD): UIMC1
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UIMC1 |
|
Disorders
/ Diseases for UIMC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UIMC1 for disorders About GeneDecksing
OMIM gene information: 609433
OMIM disorders: --
6 diseases for UIMC1: About MalaCardsbreast cancer susceptibility epithelial ovarian cancer breast cancer familial breast cancer ovarian cancer lung cancer 1 disease from the University of Copenhagen DISEASES database for UIMC1:Breast cancer Human Genome Epidemiology (HuGE) Navigator: UIMC1 (5 documents) Export disorders for UIMC1 gene to outside databases
|
Publications for UIMC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UIMC1 gene, integrated from 9 sources (see all 74): (articles sorted by number of sources associating them with UIMC1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- RAP80: a novel nuclear protein that interacts with the retinoid- related testis-associated receptor. (PubMed id 12080054)1, 2, 3, 9 Yan Z.... Jetten A.M. (2002)
- The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. (PubMed id 17621610)1, 2, 9 Yan J.... Jetten A.M. (2007)
- RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205. (PubMed id 18519686)1, 2, 9 Yan J.... Jetten A.M. (2008)
- Tandem protein interaction modules organize the ubiqui tin-dependent response to DNA double-strand breaks. (PubMed id 22742833)1, 2 Panier S....Durocher D. (2012)
- MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)1, 2 Feng L.... Chen J. (2009)
- Linkage-specific avidity defines the lysine 63-linked polyubiquitin- binding preference of rap80. (PubMed id 19328070)1, 2 Sims J.J. and Cohen R.E. (2009)
- The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8- Ubc13-dependent ubiquitination events at DNA double strand breaks. (PubMed id 19202061)1, 2 Shao G.... Greenberg R.A. (2009)
- MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)1, 2 Shao G.... Greenberg R.A. (2009)
- NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (2009)
- Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases. (PubMed id 18695986)1, 2 Novak D.J....Tischkowitz M. (2009)
|
External Searches for UIMC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UIMC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UIMC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UIMC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for UIMC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UIMC1 gene: Search GeneIP for patents involving UIMC1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for UIMC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for UIMC1 | | OriGene Custom Protein Services for UIMC1 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UIMC1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UIMC1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UIMC1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UIMC1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UIMC1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UIMC1 |
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| | | Search Tocris compounds for UIMC1 |
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 | | UIMC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UIMC1 |
|  |  |  | | | ThermoFisher Antibodies for UIMC1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UIMC1 |
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